CREDIT SUISSE FIRST BOSTON/
4, 2000-12-11
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                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     FORM 4

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

[_]  Check box if no longer  subject of Section 16. Form 4 or Form 5 obligations
     may continue. See Instruction 1(b).


________________________________________________________________________________
1.   Name and Address of Reporting Person*

     Credit Suisse First Boston,
        on behalf of the Credit Suisse First Boston business unit
--------------------------------------------------------------------------------
   (Last)                           (First)             (Middle)

     11 Madison Avenue
--------------------------------------------------------------------------------
                                    (Street)

     New York                  NY                        10010
--------------------------------------------------------------------------------
   (City)                           (State)              (Zip)


________________________________________________________________________________
2.   Issuer Name and Ticker or Trading Symbol


     IntraBiotics Pharmaceuticals, Inc. (IBPI)
________________________________________________________________________________
3.   IRS Identification Number of Reporting Person, if an Entity (Voluntary)



________________________________________________________________________________
4.   Statement for Month/Year


     November 2000
________________________________________________________________________________
5.   If Amendment, Date of Original (Month/Year)


================================================================================
6.   Relationship of Reporting Person to Issuer
     (Check all applicable)

     [_]  Director                             [X]  10% Owner
     [_]  Officer (give title below)           [_]  Other (specify below)
________________________________________________________________________________
7.   Individual or Joint/Group Filing (Check applicable line)

     [X]  Form filed by one Reporting Person
     [_]  Form filed by more than one Reporting Person
________________________________________________________________________________

<PAGE>

================================================================================
           Table I -- Non-Derivative Securities Acquired, Disposed of,
                             or Beneficially Owned
================================================================================
<TABLE>
<CAPTION>
                                                                                                                6.
                                                                 4.                              5.             Owner-
                                                                 Securities Acquired (A) or      Amount of      ship
                                                    3.           Disposed of (D)                 Securities     Form:     7.
                                                    Transaction  (Instr. 3, 4 and 5)             Beneficially   Direct    Nature of
                                      2.            Code         ------------------------------- Owned at End   (D) or    Indirect
1.                                    Transaction   (Instr. 8)                   (A)             of Month       Indirect  Beneficial
Title of Security                     Date          ------------     Amount      or     Price    (Instr. 3      (I)       Ownership
(Instr. 3)                            (mm/dd/yy)     Code     V                  (D)             and 4)         (Instr.4) (Instr. 4)
------------------------------------------------------------------------------------------------------------------------------------
<S>                                   <C>            <C>      <C>    <C>         <C>    <C>      <C>             <C>      <C>
Common Stock                          3/27/00        C                 214,093   (A)               214,093       I        (1)(2)(3)
------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          3/27/00        C               2,052,933   (A)             2,052,933       I        (1)(3)(4)
------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          3/27/00        C               1,352,727   (A)             1,352,727       I        (1)(3)(5)
------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          3/27/00        C                  23,846   (A)                23,846       I        (1)(3)(6)
===================================================================================================================================
</TABLE>
*    If the Form is filed by more than one  Reporting  Person,  see  Instruction
     4(b)(v).

Reminder: Report on a separate line for each class of securities beneficially
          owned directly or indirectly.

Potential persons who are to respond to the collection of information contained
in this form are not required to respond unless the form displays a currently
valid OMB control number.


                            (Print or Type Responses)
                                                                          (Over)


<PAGE>

FORM 4 (continued)

Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)

================================================================================
<TABLE>
<CAPTION>
                                                                                                                    10.
                                                                                                          9.        Owner-
                                                                                                          Number    ship
                                                                                                          of        Form
                    2.                                                                                    Deriv-    of
                    Conver-                    5.                              7.                         ative     Deriv-   11.
                    sion                       Number of                       Title and Amount           Secur-    ative    Nature
                    or                         Derivative    6.                of Underlying     8.       ities     Secur-   of
                    Exer-             4.       Securities    Date              Securities        Price    Bene-     ity:     In-
                    cise     3.       Trans-   Acquired (A)  Exercisable and   (Instr. 3 and 4)  of       ficially  Direct   direct
                    Price    Trans-   action   or Disposed   Expiration Date   ----------------  Deriv-   Owned     (D) or   Bene-
1.                  of       action   Code     of(D)         (Month/Day/Year)            Amount  ative    at End    In-      ficial
Title of            Deriv-   Date     (Instr.  (Instr. 3,    ----------------            or      Secur-   of        direct   Owner-
Derivative          ative    (Month/  8)       4 and 5)      Date     Expira-            Number  ity      Month     (I)      ship
Security            Secur-   Day/     ------   ------------  Exer-    tion               of      (Instr.  (Instr.   (Instr.  (Instr.
(Instr. 3)          ity      Year)    Code V    (A)   (D)    cisable  Date  Title        Shares  5)       4)        4)       4)
------------------------------------------------------------------------------------------------------------------------------------
<S>                   <C>     <C>       <C>  <C>  <C>   <C>   <C>      <C>  <C>             <C>     <C>      <C>       <C>    <C>
Series A Convertible  1:1     3/27/00   C             (D)                   Common Stock       27,933        0
Preferred
------------------------------------------------------------------------------------------------------------------------------------
Series B Convertible  1:1     3/27/00   C             (D)                   Common Stock      156,919        0
Preferred
------------------------------------------------------------------------------------------------------------------------------------
Series C Convertible  1:1     3/27/00   C             (D)                   Common Stock        6,882        0
Preferred
------------------------------------------------------------------------------------------------------------------------------------
Series D Convertible  1:1     3/27/00   C             (D)                   Common Stock       22,359        0
Preferred
------------------------------------------------------------------------------------------------------------------------------------
Series C Convertible  1:1     3/27/00   C             (D)                   Common Stock    1,839,038        0
Preferred
------------------------------------------------------------------------------------------------------------------------------------
Series D Convertible  1:1     3/27/00   C             (D)                   Common Stock      213,895        0
Preferred
------------------------------------------------------------------------------------------------------------------------------------
Series A Convertible  1:1     3/27/00   C             (D)                   Common Stock      176,406        0
Preferred
------------------------------------------------------------------------------------------------------------------------------------
Series B Convertible  1:1     3/27/00   C             (D)                   Common Stock      990,938        0
Preferred
------------------------------------------------------------------------------------------------------------------------------------
Series C Convertible  1:1     3/27/00   C             (D)                   Common Stock       44,482        0
Preferred
------------------------------------------------------------------------------------------------------------------------------------
Series D Convertible  1:1     3/27/00   C             (D)                   Common Stock      140,901        0
Preferred
------------------------------------------------------------------------------------------------------------------------------------
Series C Convertible  1:1     3/27/00   C             (D)                   Common Stock       21,362        0
Preferred
------------------------------------------------------------------------------------------------------------------------------------
Series D Convertible  1:1     3/27/00   C             (D)                   Common Stock        2,484        0
Preferred
====================================================================================================================================
</TABLE>
Explanation of Responses:

See Attachment A for footnotes:

Credit Suisse First Boston, acting
solely on behalf of the Credit Suisse
First Boston business unit

/s/ Lindsay Hollister                                    12/11/00
---------------------------------------------            ---------
By: Lindsay Hollister, Director                          Date
**Signature of Reporting Person


**     Intentional misstatements or omissions of facts constitute Federal
       Criminal Violations.

       See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:  File three copies of this Form, one of which must be manually signed.
       If space provided is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained
in this form are not required to respond unless the form displays a currently
valid OMB number.
<PAGE>

                                                                    Attachment A


                           EXPLANATION TO RESPONSES:


(1)  Credit Suisse First Boston (USA) Inc. ("CSFB-USA"), a Delaware corporation
     formerly named Donaldson, Lufkin & Jenrette, Inc., is the parent of DLJ
     Capital Corporation ("DLJCC"). DLJCC is the parent of DLJ Capital
     Associates VII, Inc., which is the General Partner of DLJ Associates VII,
     L.P., which is the General Partner of Sprout Capital VII, L.P. DLJCC is
     also parent of DLJ Capital Associates VI, Inc., which is the General
     Partner of DLJ Associates VI, L.P., which is the General Partner of Sprout
     Capital VI, L.P.

(2)  These securities are directly held by DLJCC.

(3)  This Form 4 is being filed by Credit Suisse First Boston (the "Bank"), a
     Swiss bank, on behalf of itself and its subsidiaries, to the extent that
     they constitute part of the Credit Suisse First Boston business unit (the
     "CSFB business unit" or the "Reporting Person"). The CSFB business unit is
     engaged in the corporate and investment banking, trading (equity, fixed
     income and foreign exchange), private equity investment and derivatives
     businesses on a worldwide basis. The Bank and its subsidiaries engage in
     other separately managed activities, most of which constitute the
     independently operated Credit Suisse Asset Management business unit; the
     Credit Suisse Asset Management business unit provides asset management and
     investment advisory services to institutional investors worldwide.

     Credit Suisse First Boston, Inc. ("CSFBI"), a Delaware corporation, owns
     100% of the voting stock of CSFB-USA. The Bank owns a majority of the
     voting stock, and all of the non-voting stock, of CSFBI. The ultimate
     parent company of the Bank and CSFBI, and the direct owner of the remainder
     of the voting stock of CSFBI, is Credit Suisse Group, a corporation formed
     under the laws of Switzerland ("CSG").

     The principal business of CSG is acting as a holding company for a global
     financial services group with five distinct specialized business units that
     are independently operated. In addition to the two business units referred
     to above, CSG and its consolidated subsidiaries (other than the Bank and
     its subsidiaries) are comprised of (a) the Credit Suisse Private Bank
     business unit that engages in the global private banking business; (b) the
     Credit Suisse business unit that engages in the Swiss domestic banking
     business and (c) the Winterthur business unit that engages in the global
     insurance business. CSG's business address is Paradeplatz 8, Postfach 1,
     CH-8070, Zurich, Switzerland.

     CSG, for purposes of federal securities laws, may be deemed ultimately to
     control the Bank, and the CSFB business unit. CSG, its executive officers
     and directors, and its direct and indirect subsidiaries (including all of
     the business units except the CSFB business unit), may beneficially own
     securities issued by the Issuer or derivative securities relating thereto,
     and any such securities are not reported in this statement. Due to the
     separate management and independent operation of its business units, CSG
     disclaims beneficial ownership of any such securities beneficially owned by
     its direct and indirect subsidiaries, including the Reporting Person. The
     Reporting Person disclaims beneficial ownership of any such securities
     beneficially owned by CSG and any of CSG's and the Bank's other business
     units.

     The Reporting Person disclaims beneficial ownership of securities held
     directly by any entity described herein except with respect to the
     Reporting Person's proportionate interest in or ownership of such entity.
     The filing of this statement shall not be construed for purposes of Section
     16 of the Securities Exchange Act of 1934, as amended, as an admission of
     beneficial ownership of the securities reported on this statement.

(4)  These securities are held directly by Sprout Capital VII, L.P. DLJCC is the
     Managing General Partner of such partnership.

(5)  These securities are held directly by Sprout Capital VI., L.P. DLJCC is the
     Managing General Partner of such partnership.

(6)  These securities are held directly by Sprout CEO Fund, L.P. DLJCC is the
     General Partner of such partnership.



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