OPPENHEIMER GLOBAL BIO TECH FUND
497, 1994-07-08
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                     OPPENHEIMER GLOBAL BIO-TECH FUND
                       Supplement dated July 5, 1994
                 to the Prospectus dated February 1, 1994

The Prospectus is amended as follows:

The second paragraph under the caption "How To Buy Shares -- Minimum
Investment" on page 11 is deleted and replaced with the following:

   Shares of the Fund are not available for sale to new investors,
   including shares purchased by exchange from "Eligible Funds"
   (defined below), lump-sum purchases, and purchases under an Asset
   Builder Plan (described below) or by reinvestment of dividends or
   distributions from other "Eligible Funds," or under the
   "Reinvestment Privilege," described below.  Existing Fund
   shareholders may purchase Fund shares in amounts up to $25,000 per
   investor per month, including within that limit shares purchased by
   exchange from "Eligible Funds," lump-sum purchases, and purchases
   under an Asset Builder Plan or by reinvestment of dividends or
   distributions from other "Eligible Funds," or under the
   "Reinvestment Privilege."  The $25,000 monthly limit on purchases
   described in the previous sentence does not apply to purchases of
   shares in the amount of $1 million or more by an "institutional
   investor." The determination as to whether a particular investor is
   an "institutional investor" shall be made by the Distributor, in its
   sole discretion, based upon information provided to it at the time
   of purchase by the investor or the investor's dealer and which is
   satisfactory to the Distributor.  The foregoing is subject to the
   right of the Fund and the Distributor, in their complete discretion,
   to modify or terminate the terms of this offer at any time without
   prior notice.  The remaining sections of this Prospectus are hereby
   amended to conform to the terms of this offer.


July 5, 1994                                                   PS750



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