OPPENHEIMER GLOBAL BIO TECH FUND
497, 1994-06-22
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                     OPPENHEIMER GLOBAL BIO-TECH FUND
                      Supplement dated June 16, 1994
                 to the Prospectus dated February 1, 1994

The Prospectus is amended as follows:

1.  The Prospectus supplement dated February 3, 1994 is hereby replaced
with this supplement.

2.  The following text is inserted after the first sentence in the second
paragraph in the section of the Prospectus entitled "How To Buy Shares --
Minimum Investment":

   The $25,000 monthly limit on purchases described in the previous
   sentence does not apply to purchases of shares in the amount of $1
   million or more by an "institutional investor." The determination
   as to whether a particular investor is an "institutional investor"
   shall be made by the Distributor, in its sole discretion, based upon
   information provided to it at the time of purchase by the investor
   or the investor's dealer and which is satisfactory to the
   Distributor.

3.  At a meeting held June 16, 1994, the Fund's Board of Trustees
unanimously approved and recommended that the Fund's shareholders approve
the Manager's proposal that the Fund be restructured as a global small cap
fund.  Shareholders of the Fund will be asked, at a meeting currently
scheduled for September 18, 1994, to approve a proposal to remove the
fundamental policy that the Fund will normally invest at least 65% of its
total assets in securities of biotechnology companies located worldwide
and to replace that policy with one whereby the Fund would normally invest
at least 65% of its total assets in securities of small cap issuers
located worldwide.

   If the Fund's shareholders approve this proposal, the Board anticipates
that it will change the Fund's name to Oppenheimer Global Small Cap Fund. 
A proxy statement and other soliciting materials describing the proposal
in more detail will be mailed in early August, 1994 to shareholders of
record as of July 15, 1994, the record date for the shareholders meeting. 
Shareholders of the Fund that first acquired Fund shares after the record
date for the shareholders meeting will not be entitled to vote on the
proposal.


June 16, 1994                                              PS750



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