ZILA INC
S-3, 1996-02-01
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
 
    AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON FEBRUARY 1, 1996
                                                      REGISTRATION NO. 33-
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
 
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                             ---------------------
 
                                    FORM S-3
            REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
                             ---------------------
 
                                   ZILA, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
 
<TABLE>
<S>                                                <C>
                     DELAWARE                                          86-0619668
          (STATE OR OTHER JURISDICTION OF                             (IRS EMPLOYER
          INCORPORATION OR ORGANIZATION)                         IDENTIFICATION NUMBER)
</TABLE>
 
                             5227 NORTH 7TH STREET
                             PHOENIX, ARIZONA 85014
                                 (602) 266-6700
         (ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING
            AREA CODE, OF REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)
                             ---------------------
 
                                MR. JOSEPH HINES
                                   ZILA, INC.
                             5227 NORTH 7TH STREET
                          PHOENIX, ARIZONA 85014-2800
                                 (602) 266-6700
           (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER,
             INCLUDING AREA CODE, OF AGENT FOR SERVICE OF SERVICE)
                             ---------------------
 
      THE COMMISSION IS REQUESTED TO SEND COPIES OF ALL COMMUNICATIONS TO:
 
                             KEVIN J. TOUREK, ESQ.
                               STREICH LANG, P.A.
                             2 NORTH CENTRAL AVENUE
                          PHOENIX, ARIZONA 85004-2391
                                 (602) 229-5200
                             ---------------------
 
 APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE OF THE SECURITIES TO PUBLIC:
    From time to time after the Registration Statement becomes effective as
 determined by market conditions and the needs of the Selling Securityholders.
 
     If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box. / /
 
     If any of the securities being registered on this Form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. /X/
 
     If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. / /
 
     If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. / /
 
     If delivery of this prospectus is expected to be made pursuant to Rule 434,
please check the following box. / /
                             ---------------------
 
                        CALCULATION OF REGISTRATION FEE
 
<TABLE>
- ------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------
                                                                           PROPOSED MAXIMUM
                                                          PROPOSED MAXIMUM    AGGREGATE
TITLE OF EACH CLASS OF                     AMOUNT TO BE    OFFERING PRICE      OFFERING        AMOUNT OF
SECURITIES TO BE REGISTERED               REGISTERED(1)     PER UNIT(2)         PRICE       REGISTRATION FEE
- ------------------------------------------------------------------------------------------------------------
<S>                                      <C>              <C>              <C>              <C>
Common Stock, $.001 par value...........     329,655           $5.50        $1,813,102.50       $625.21
- ------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------
</TABLE>
 
(1) In the event of a stock split, stock dividends, or similar transaction
    involving the Company's Common Stock, in order to prevent dilution, the
    number of shares registered shall automatically be increased to cover the
    additional shares in accordance with Rule 416(a) under the Securities Act.
 
(2) Estimated solely for the purpose of calculating the registration fee based
    upon the average of the bid and asked price for the Common Stock on January
    29, 1996.
                             ---------------------
 
     THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT") OR UNTIL THE
REGISTRATION STATEMENT SHALL BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION,
ACTING PURSUANT TO SAID SECTION 8(A), MAY DETERMINE.
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
<PAGE>   2
 
     INFORMATION CONTAINED HEREIN IS SUBJECT TO COMPLETION OR AMENDMENT. A
     REGISTRATION STATEMENT RELATING TO THESE SECURITIES HAS BEEN FILED WITH THE
     SECURITIES AND EXCHANGE COMMISSION. THESE SECURITIES MAY NOT BE SOLD NOR
     MAY OFFERS TO BUY BE ACCEPTED PRIOR TO THE TIME THE REGISTRATION STATEMENT
     BECOMES EFFECTIVE. THIS PROSPECTUS SHALL NOT CONSTITUTE AN OFFER TO SELL OR
     THE SOLICITATION OF AN OFFER TO BUY NOR SHALL THERE BE ANY SALE OF THESE
     SECURITIES IN ANY STATE IN WHICH SUCH OFFER, SOLICITATION OR SALE WOULD BE
     UNLAWFUL PRIOR TO REGISTRATION OR QUALIFICATION UNDER THE SECURITIES LAWS
     OF ANY SUCH STATE.
 
                [SUBJECT TO COMPLETION, DATED FEBRUARY 1, 1996]
 
                                   ZILA, INC.
 
                 329,655 SHARES OF COMMON STOCK, .001 PAR VALUE
 
                             ---------------------
 
     The securities offered hereby (the "Offered Securities") are 329,655 shares
of common stock, $.001 par value ("Common Stock"), of Zila, Inc., a Delaware
corporation (the "Company"). Of the 329,655 shares of the Common Stock, (i)
85,280 shares are issuable upon the exercise of outstanding warrants to purchase
shares of Common Stock (the "Warrants"), (ii) 10,000 shares were previously
issued in connection with the exercise of warrants and are presently
outstanding; and (iii) 234,375 shares were previously issued in connection with
a private placement of the Company's Common Stock and are presently outstanding.
 
     All the securities being offered hereby may be sold from time to time by
certain Selling Securityholders. See "SELLING SECURITYHOLDERS." The Company will
not receive any of the proceeds from the sale of the Offered Securities by the
Selling Securityholders. The Offered Securities may be offered from time to time
in one or more transactions in the over-the-counter market, pursuant to Rule 144
under the Securities Act of 1933, or otherwise, at market prices prevailing at
the time of sale, at prices relating to such prevailing market prices, or at
negotiated prices, and without payment of any underwriting discounts or
commissions except for usual and customary selling commissions paid to brokers
or dealers. All expenses in connection with the registration of the securities
will be borne by the Company. See "RISK FACTORS," "PLAN OF DISTRIBUTION" and
"SELLING SECURITYHOLDERS."
 
     The Common Stock is listed on the National Association of Securities
Dealers Automated Quotation System ("NASDAQ") under the Symbol "ZILA." On
January 29, 1996, the mean of the closing bid and asked quotations per share of
the Common Stock, as provided by market makers in the Common Stock who report
through NASDAQ was $5.50 per share.
 
         SEE "RISK FACTORS" ON PAGE 4 FOR A DISCUSSION OF CERTAIN RISKS
                 RELATED TO AN INVESTMENT IN THE COMMON STOCK.
 
                             ---------------------
 
   THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
     AND EXCHANGE COMMISSION NOR HAS THE COMMISSION PASSED UPON THE
        ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO
          THE CONTRARY IS A CRIMINAL OFFENSE.
 
               The date of this Prospectus is             , 1996.
<PAGE>   3
 
                             AVAILABLE INFORMATION
 
     The Company is subject to the informational requirements of the Securities
Exchange Act of 1934 (the "Exchange Act") and, in accordance therewith files
reports, proxy statements and other information with the Securities and Exchange
Commission (the "Commission"). Such reports, proxy statements and other
information filed with the Commission can be inspected and copied at the public
reference facilities maintained by the Commission at 450 Fifth Street, N.W.,
Washington, D.C., and at the Commission's regional offices at 500 West Madison
Street, Suite 1400, Chicago, Illinois 60661; and 7 World Trade Center, 13th
Floor, New York, New York 10048. Copies of such material can also be obtained at
prescribed rates from the Public Reference section of the Commission at its
principal office at 450 Fifth Street, N.W., Washington, D.C. 20549.
 
     This Prospectus constitutes a part of a Registration Statement on Form S-3
(together with all amendments and exhibits thereto, the "Registration
Statement") filed by the Company with the Commission under the Securities Act of
1933, as amended (the "Securities Act"). As permitted by the rules and
regulations of the Commission, this Prospectus omits certain information
contained in the Registration Statement, and reference is made to the
Registration Statement and related exhibits for further information with respect
to the Company and the securities offered hereby. Any statements contained
herein concerning the provisions of any document filed as an exhibit to the
Registration Statement or otherwise filed with the Commission are not
necessarily complete, and in each instance reference is made to the copy of such
document so filed. Each such statement is qualified in its entirety by such
reference.
 
                INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
 
     The following documents previously filed by the Company with the Commission
are incorporated by reference into this Prospectus: (i) the Company's Annual
Report on Form 10-K for the fiscal year ended July 31, 1995; (ii) the Company's
Quarterly Report on Form 10-Q for the quarterly period ended October 31, 1995;
(iii) the Company's Current Report on Form 8-K dated (date of earliest event
reported) February 1, 1996; and (iv) the description of the Common Stock
contained in the Company's Registration of Certain Classes of Securities
Pursuant to Section 12(b) or (g) of the Securities Exchange Act of 1934 on Form
8-A dated March 1, 1989, as amended from time to time.
 
     All other documents filed by the Company pursuant to Sections 13(a), 13(c),
14 and 15(d) of the Exchange Act subsequent to the date of this Prospectus and
prior to the termination of the offering made hereby shall be deemed to be
incorporated by reference herein and to be part hereof from the date of the
filing of such reports and documents.
 
     Any statement contained in a document incorporated or deemed incorporated
by reference herein shall be deemed to be modified or superseded for purposes of
this Prospectus to the extent that a statement contained herein or in any
subsequently filed document that is also deemed to be incorporated by reference
herein modifies or supersedes such statement. Any such statement so modified or
superseded shall not be deemed, except as so modified or superseded, to
constitute a part of this Prospectus.
 
     The Company hereby undertakes to provide without charge to each person,
including a beneficial owner, to whom a Prospectus is delivered upon written or
oral request of each person, a copy of any document incorporated herein by
reference, (not including exhibits to the document that have been incorporated
herein by reference unless such exhibits are specifically incorporated by
reference in the document which this Prospectus incorporates). Requests should
be directed to President, Zila, Inc., 5227 North 7th Street, Phoenix Arizona
85014-2800; telephone (602) 266-6700.
 
                                        2
<PAGE>   4
 
                               PROSPECTUS SUMMARY
 
     The following summary is qualified in its entirety by reference to the more
detailed information and financial statements appearing elsewhere in and
incorporated by reference into this Prospectus. The shares offered hereby are
speculative and involve a high degree of risk. See "RISK FACTORS."
 
                                  THE COMPANY
 
     The Company's primary emphasis is on the marketing of three
over-the-counter, non-prescription products, ZILACTIN(R), ZILACTIN(R)-L
(formerly ZILACTOL(R)) and ZILACTIN(R)-B. These products are over-the-counter,
non-prescription gels and liquids used topically for symptomatic relief of
canker sores (oral mucosal ulcers), cold sores, fever blisters and abrasions.
The ZILACTIN(R) treatment composition is covered by patents owned by the
Company. ZILACTIN(R), ZILACTIN(R)-L and ZILACTIN(R)-B formulas incorporate these
proprietary treatment compositions. First manufactured in 1984, ZILACTIN(R) was
introduced in major drug stores in the Phoenix area and is currently carried by
major drug stores and retail chains throughout the United States. The Company is
also seeking government approval from the Food and Drug Administration (the
"FDA") and the countries of the European Union ("EU") to distribute ORASCAN, a
fourth product, in the United States and Europe. ORASCAN has been approved for
distribution in the United Kingdom, Canada and Australia. ORASCAN is a
diagnostic for oral cancer and site delineation device for biopsy and surgical
excision.
 
     The Company is incorporated in the State of Delaware. The Company's
principal executive offices are located at 5227 North Seventh Street, Phoenix,
Arizona 85014-2800 and its telephone number is (602) 266-6700.
 
                                  THE OFFERING
 
<TABLE>
<S>                                            <C>
Securities offered...........................  329,655 shares of Common Stock
Common Stock outstanding as of January 31,
  1996.......................................  24,557,230 shares of Common Stock
NASDAQ Symbol................................  ZILA
</TABLE>
 
                                        3
<PAGE>   5
 
                                  RISK FACTORS
 
     This offering involves a high degree of risk. Prospective investors should
carefully consider, among other factors, the following risks relating to the
Company, its business and this offering:
 
     1. No Assurance of Profitable Operations.  For the fiscal years ended July
31, 1995 and 1994, the Company had net losses of $862,920 and $995,205,
respectively, compared with net income of $369,949 for the fiscal year ended
July 31, 1993. The Company has had profitable operations in only one of its last
three fiscal years. There can be no assurance that the Company will, in the
future, return to profitability or that the Company's plan for expanded
operations will be successful.
 
     2. Dependence on Key Personnel.  The operations of the Company depend to a
great extent on the technical expertise and management efforts of Mr. Joseph
Hines, President of the Company, Mr. Clarence Baudhuin, Executive Vice President
of the Company, Mr. Edwin Pomerantz, Vice President of Regulatory and Technical
Affairs, and Ms. Janice Backus, Vice President and Corporate Secretary. The loss
of Messrs. Hines, Baudhuin or Pomerantz or Ms. Backus could materially adversely
affect the Company's business. The Company does not maintain key person life
insurance coverage on these personnel.
 
     3. Competition; Research and Development.  The pharmaceutical industry is
highly competitive. A number of companies, many of which have greater financial
resources, marketing capabilities and research and development capacity than the
Company, are actively engaged in the development of products similar to those
products produced and marketed by the Company. The Company relies on outside
sources for its on-going research and development needs in much the same manner
as the Company relies on outside sources for manufacturing. The pharmaceutical
industry is characterized by extensive and on-going research efforts. Other
companies may succeed in developing products superior to those marketed by the
Company. Such companies may even succeed in developing a cure for herpes simplex
virus, which would substantially reduce the potential market for symptomatic
treatments such as ZILACTIN(R).
 
     4. Government Regulation.  The approval and sale of pharmaceutical products
is heavily regulated by the Food and Drug Administration (the "FDA") and other
federal and state regulatory agencies. Such regulation encompasses pricing,
safety and efficacy, testing, advertising and promotion, labeling of
pharmaceutical products and other matters. Compliance with such regulations is
both costly and time consuming. In order to be legally marketed over-the-counter
("OTC"), a product must either be the subject of a New Drug Application ("NDA")
approved by the FDA, be the subject of an applicable FDA monograph designating
the product generally recognized as safe and effective or, if no FDA monograph
exists, be "grandfathered" as a result of the use of such product or similar
products prior to December 5, 1975. ZILACTIN(R) is currently being marketed for
the symptomatic relief of canker sores (oral mucosal ulcers or lesions), cold
sores, and fever blisters. The product is "grandfathered" and a letter has been
received by the Company from the FDA confirming its status. ZILACTIN(TM)-L (for
the treatment of fever blisters and cold sores before they erupt) is also
marketed as a "grandfathered" product. Neither of these products may be marketed
as a treatment for genital herpes or herpes zoster (commonly known as
"shingles") without an effective new drug application. Depending principally on
the time and expense involved, NDAs seeking approval for marketing ZILACTIN(R)
and/or ZILACTIN(R)-L as topical applications for the treatment of shingles and
genital herpes may be filed by the Company. There can be no assurance that any
NDA will be filed with/or approved by the FDA. Any challenge by the FDA of the
Company's sale of or claims for ZILACTIN(R) would materially adversely affect
the business and prospects of the Company. The Company is also seeking FDA and
EU approval of ORASCAN, an oral cancer diagnostic. There can be no assurance
that FDA or EU approval of ORASCAN will be obtained.
 
     5. Possible Claims Relating to Products.  The Company could be exposed to
possible claims for personal injury resulting from allegedly defective products
manufactured by third parties with which it has entered into manufacturing
agreements. The Company maintains product liability insurance coverage for
claims arising from the use of all its products. However, there can be no
assurance that the Company will not be subject to product liability claims in
excess of its insurance coverage. Any significant product liability claims not
within the scope of the Company's insurance coverage could have a material
adverse effect on the Company.
 
                                        4
<PAGE>   6
 
     6. No Cash Dividends.  The Company has never paid cash dividends on its
Common Stock and does not contemplate paying cash dividends in the foreseeable
future.
 
     7. Patents and Trademarks.  The Company holds three United States patents
and one Canadian patent which cover the ZILACTIN(R) treatment composition,
certain extended applications of the basic treatment composition formula and the
film-forming properties of the product. No assurance can be given that the
validity of any patents issued to or held by the Company would be confirmed in a
court test or that the scope of these patents is adequate to effectively limit
competition against the Company.
 
     The Company has also registered the trademark ZILACTIN(R) with the United
States Patent and Trademark Office and has registered the trademark "ZILA" in
the United States. If the Company is unable to adequately protect its mark or
marks against use of similar marks or names, the Company's business could be
materially adversely affected.
 
     8. Charter and Bylaw Provisions.  The Company's Certificate of
Incorporation, as amended, and Bylaws contain provisions that limit or eliminate
director liability for certain actions. These provisions could, in some
instances, prevent redress by stockholders for certain actions taken by the
Company's directors.
 
     9. Warrants and Options.  At January 31, 1996, 2,387,803 shares of Common
Stock are issuable upon the exercise of outstanding options and warrants to
purchase shares of Common Stock, including warrants to purchase 915,672 shares
and options to purchase 1,472,131 shares. For the life of such options and
warrants, the option and warrant holders will have the opportunity to profit
from a rise in the price of the Common Stock, with a resulting dilution in the
interest of other holders of the Common Stock. The existence of such options and
warrants may adversely affect the terms on which the Company can obtain
additional financing. Further, the warrant and option holders can be expected to
exercise their warrants and options at a time when the Company would, in all
likelihood, be able to obtain additional capital by an offering of its unissued
Common Stock on terms more favorable to the Company than those provided by such
options and warrants.
 
     10. Shares Eligible for Future Sale.  As of January 31, 1996, the Company
had 24,557,230 shares of Common Stock outstanding. An additional 2,387,803
shares of Common Stock are issuable upon exercise of outstanding options and
warrants to purchase Common Stock. Such shares, subject to certain limitations,
may be available in the future for resale in the open market pursuant to Rule
144 promulgated under the Securities Act, as amended or pursuant to registration
of such shares under the Securities Act. The foregoing resales, if any, may have
an adverse effect on the market price of the Common Stock.
 
     11. Litigation.  In written and oral communications with the Company, CTM
Associates, Inc. ("CTM") has asserted the position that the Company was not
authorized to enter into a License Agreement with Block Drug Company, Inc.
("Block") for marketing of OraScan in Europe without CTM's prior consent and
that the License Agreement with Block is invalid. The Company does not believe
CTM's position has any legal merit and has filed a declaratory judgment action
against CTM in federal district court in Phoenix, Arizona requesting that the
court enter judgment in the Company's favor to the effect that the consent of
CTM was not required and that a failure to obtain CTM's consent has no effect on
the validity of the License Agreement. The Company also filed a summary judgment
motion seeking a judgment that it is absolute owner of the OraScan patents and
technology assigned to it by CTM, rather than a licensee of such patents and
technology as has been asserted by CTM. CTM has filed an answer denying the
allegations in the Company's complaint, has counterclaimed for declaratory
relief regarding the Company's claims, and has filed a response to the Company's
Motion for Summary Judgment. A hearing on the Company's motion is scheduled for
February 12, 1996. If the Company were ultimately unsuccessful in obtaining the
requested relief, such a result could possibly have a material adverse effect on
the Company's OraScan marketing efforts and on the Company.
 
                                USE OF PROCEEDS
 
     The net proceeds of this offering will be received directly by each Selling
Securityholder. No proceeds will be received by the Company from the sale of the
Common Stock offered hereby.
 
                                        5
<PAGE>   7
 
                        DETERMINATION OF OFFERING PRICE
 
     This Prospectus may be used from time to time by the Selling
Securityholders who offer the Common Stock registered hereby for sale. The
offering price of such Common Stock will be determined by the Selling
Securityholder and may be based on market prices prevailing at the time of sale,
at prices relating to such prevailing market prices, or at negotiated prices.
 
                            SELLING SECURITYHOLDERS
 
     The following table provides certain information with respect to the Common
Stock beneficially owned by the Selling Securityholders who are entitled to use
this Prospectus. The information in the table is as of the date of this
Prospectus. Except as described below, no Selling Securityholder has had a
material relationship with the Company within the past three years other than as
a result of the ownership of Common Stock. The Common Stock offered by this
Prospectus may be offered from time to time by the Selling Securityholders named
below or their nominees:
 
<TABLE>
<CAPTION>
                                                                                        SHARES       PERCENT
                                                                                      AVAILABLE    OWNED AFTER
                                               SHARES                                  FOR SALE     COMPLETION
          NAME AND ADDRESS OF SELLING       BENEFICIALLY                              UNDER THIS      OF THE
               SECURITYHOLDER(1)              OWNED(2)     WARRANTS(3)   OPTIONS(4)   PROSPECTUS   OFFERING(5)
     -------------------------------------  ------------   -----------   ----------   ----------   ------------
<C>  <S>                                    <C>            <C>           <C>          <C>          <C>
  1. Blue Mountain Financial Inc. ........        20,000      20,000             0        20,000      *
       30300 Northwestern Hwy.
       Farmington Hills, MI 48334
  2. Beverly A. Brown.....................        34,583       3,333             0        34,583      *
       P.O. Box 551
       Ossipee, NH 03864
  3. Egidio Cianciosi.....................         5,280       5,280             0         5,280      *
       8230 E. Thoroughbred Trail
       Scottsdale, AZ 85258
  4. Gregory J. Danowski..................       224,792      21,667             0       224,792      *
       27952 Trailwood Court
       Farmington Hills, MI 48331
  5. Jonathan Gelles......................        25,000      25,000             0        25,000      *
       120 Cheapside
       London EC2 England
  6. Arthur Mashberg......................        10,000           0             0        10,000      *
       13 Kent Drive
       Roseland, NJ 07068
  7. Carl A. Schroeder(6).................        22,500      10,000        12,500        10,000      *
       10731 Kelso Drive
       Sun City, AZ 85351
  8. All Selling Securityholders as a            342,155      85,280        12,500       329,655      *
     group................................
     (7 persons)
</TABLE>
 
- ---------------
 *  Less than 1%.
 
(1) Except as indicated in this Prospectus for Selling Securityholder No. 7,
    none of the remaining Selling Securityholders have had any position, office
    or material relationship with the Company within the last three years.
 
(2) Includes the shares owned prior to this offering and the shares which are
    issuable upon the exercise of the warrants and/or options to acquire shares
    held by the Selling Securityholders. The number of shares being offered
    hereby is shown in the "Shares Available for Sale Under this Prospectus"
    column. See footnotes (3) and (4) below.
 
(3) Warrants for the purchase of the individual and aggregate number of shares
    of Common Stock shown below.
 
                                        6
<PAGE>   8
 
(4) Options for the purchase of the individual and aggregate number of shares of
    Common Stock shown below.
 
(5) Percentages are based upon the assumption that, upon the completion of this
    offering, the respective Selling Securityholder has sold the Common Stock
    listed as "Shares Available for Sale Under this Prospectus" and are computed
    on the basis of full dilution and 24,557,230 shares of Common Stock issued
    and outstanding as of January 31, 1996.
 
(6) Member of the Company's Board of Directors.
 
     Because (1) a Selling Securityholder may offer all or some of the shares of
Common Stock which it holds pursuant to the offerings contemplated by this
Prospectus, (2) the offerings of shares of Common Stock are not necessarily
being underwritten on a firm commitment basis, and (3) a Selling Securityholder
could purchase additional shares of Common Stock from time to time, no estimate
can be given as to the amount of shares of Common Stock that will be held by any
Selling Securityholder upon termination of such offerings. See "PLAN OF
DISTRIBUTION."
 
                              PLAN OF DISTRIBUTION
 
     The Selling Securityholders may from time to time offer the shares of
Common Stock through underwriters, dealers or agents, who may receive
compensation in the form of underwriting discounts, concessions or commissions
from the Selling Securityholders and/or the purchasers of the Common Stock for
whom they may act as agent. The Selling Securityholders and any underwriter,
dealer or agent that participate in the distribution of the Common Stock may be
deemed to be underwriters, and any profit on the sale of the Common Stock by
them and any discounts, commissions or concessions received by any such
underwriters, dealers or agents might be deemed to be underwriting discounts and
commissions under the Securities Act. At the time a particular offering of
Common Stock is made, to the extent required, a Prospectus Supplement will be
distributed with this Prospectus which will set forth the aggregate number of
shares being offered and the terms of the offering, including the names of any
underwriters, dealers or agents, any discount, commissions and other items
constituting compensation from the Selling Securityholders and any discounts or
concessions allowed or reallowed or paid to dealers. In the event a Selling
Securityholder sells the Common Stock through the use of an underwriter, it may
be necessary to file a post-effective amendment to the Registration Statement
registering the Common Stock.
 
     Alternatively, the Selling Securityholders may from time to time effect
sales of the shares of Common Stock offered hereunder in one or more
transactions in the over-the-counter market pursuant to Rule 144 under the
Securities Act, or otherwise, at market prices prevailing at the time of sale,
at prices relating to such prevailing market prices, or at negotiated prices. It
is anticipated that broker-dealers participating in such sales of Common Stock
will receive the usual and customary selling commissions.
 
     The Company will pay substantially all of the expenses incident to the
registration of the Common Stock. The Company will not pay any expenses incident
to the offering and sale of the Common Stock to the public, including, but not
limited to commissions and discounts of underwriters, dealers or agents.
 
                                 LEGAL MATTERS
 
     The legality of the securities offered hereby has been passed upon for the
Company by Streich Lang, P.A., Phoenix, Arizona.
 
                                    EXPERTS
 
     The consolidated financial statements and the related financial statement
schedules incorporated in this Prospectus by reference from the Company's Annual
Report on Form 10-K for the fiscal year ended July 31, 1995 have been audited by
Deloitte & Touche LLP, independent auditors, as stated in their reports, which
are incorporated herein by reference, and have been so incorporated in reliance
upon the report of such firm given upon their authority as experts in accounting
and auditing.
 
                                        7
<PAGE>   9
================================================================================
 
NO DEALER, SALESMAN OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO GIVE ANY
INFORMATION OR TO MAKE ANY REPRESENTATION NOT CONTAINED IN THIS PROSPECTUS IN
CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS. IF GIVEN OR MADE, SUCH
INFORMATION OR REPRESENTATION MUST NOT BE RELIED UPON AS HAVING BEEN AUTHORIZED
BY THE COMPANY. THIS PROSPECTUS DOES NOT CONSTITUTE AN OFFER OF ANY SECURITIES
OTHER THAN THE REGISTERED SECURITIES TO WHICH IT RELATES OR AN OFFER TO ANY
PERSON IN ANY JURISDICTION IN WHICH SUCH AN OFFER WOULD BE UNLAWFUL. NEITHER
DELIVERY OF THIS PROSPECTUS NOR ANY SALE MADE HEREUNDER SHALL UNDER ANY
CIRCUMSTANCES CREATE AN IMPLICATION THAT INFORMATION CONTAINED HEREIN IS CORRECT
AS OF ANY TIME SUBSEQUENT TO THE DATE OF THIS PROSPECTUS.
 
                             ---------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<CAPTION>
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<S>                                     <C>
Available Information.................    2
Incorporation of Certain
  Documents by Reference..............    2
Prospectus Summary....................    3
Risk Factors..........................    4
Use of Proceeds.......................    5
Determination of Offering Price.......    6
Selling Securityholders...............    6
Plan of Distribution..................    7
Legal Matters.........................    7
Experts...............................    7
</TABLE>
 
================================================================================

================================================================================

                                   ZILA, INC.

                                 329,655 SHARES
                                $0.001 PAR VALUE

                                   ----------
                                   PROSPECTUS
                                   ----------


                               JANUARY     , 1996

================================================================================

================================================================================

<PAGE>   10
 
                                    PART II
 
                   INFORMATION NOT REQUIRED IN THE PROSPECTUS
 
ITEM 14.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.
 
     The following table sets forth the estimated costs and expenses of the
Company in connection with the offering described in the Registration Statement.
 
<TABLE>
    <S>                                                                        <C>
    Securities and Exchange Commission Registration Fee......................  $   625.21
    Legal Fees and Expenses..................................................    4,000.00
    Accounting Fees and Expenses.............................................    5,000.00
    Other Expenses...........................................................    2,500.00
                                                                               ----------
              Total Expenses.................................................  $12,125.21
                                                                               ==========
</TABLE>
 
ITEM 15.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.
 
     Article 11 of the Company's Certificate of Incorporation, as amended (the
"Certificate of Incorporation"), limits, to the full extent permitted by
Delaware law, directors' personal liability to the Company or its stockholders
for monetary damages for breach of fiduciary duty. Section 102 of the Delaware
General Corporation Law, as amended, enables a corporation to eliminate or limit
personal liability of members of its board of directors for violations of their
fiduciary duty of care. However, Delaware law does not permit the elimination of
a director's liability for breaching his duty of loyalty, failing to act in good
faith, engaging in intentional misconduct, knowingly violating a law, unlawfully
paying a dividend or approving a stock repurchase or obtaining an improper
personal benefit. The limitation of liability provided by the statute continues
after a director has ceased to occupy such position. The statute has no effect
on the availability of equitable remedies, such as an injunction or rescission,
for breach of fiduciary duty.
 
     Article X of the Company's Bylaws requires indemnification of directors and
officers of the Company to the full extent permitted by Delaware law for claims
against them in their official capacities, including stockholders' derivative
actions. Article X requires that the Company advance expenses incurred in the
defense of such claims and continue the right of indemnification for persons who
have ceased to be directors or officers, and permits the Company to enter into
indemnification agreements with its directors and officers.
 
     Section 145 of the Delaware General Corporation Law, as amended, applies to
the Company and provides for the indemnification of officers and directors in
specified instances. It permits a corporation, pursuant to a bylaw provision in
an indemnity contract, to pay an officer's or director's litigation expenses in
advance of a proceeding's final disposition, and provides that rights arising
under an indemnity agreement or bylaw provision may continue as to a person who
has ceased to be a director or officer.
 
     The Company currently maintains directors' and officers' liability
insurance to supplement the protection provided in the Company's Certificate of
Incorporation and Bylaws and to fund any indemnification payments that the
Company may be required to make. Such insurance is renewable annually and is
subject to standard terms and conditions, including exclusions from coverage.
 
     The above discussion is qualified in its entirety by reference to the
Company's Certificate of Incorporation and Bylaws. See Exhibits 4-A and 4-B to
this Registration Statement.
 
                                      II-1
<PAGE>   11
 
ITEM 16.  EXHIBITS
 
<TABLE>
<CAPTION>
EXHIBIT                                                               PAGE NUMBER
NUMBER                  DESCRIPTION                                 METHOD OF FILING
- -------  ------------------------------------------    ------------------------------------------
<S>      <C>                                           <C>
  4-A    Certificate of Incorporation, as amended      Incorporated by reference to Exhibit 3-A
                                                       of the Company's Annual Report on Form
                                                       10-K for the fiscal Year ended July 31,
                                                       1988. (the "1988 10-K")
  4-B    Bylaws                                        Incorporated by reference to Exhibit 3-B
                                                       of the 1988 10-K.
  4-C    Specimen Common Stock Certificate             Incorporated by reference to Exhibit 4-A
                                                       of the 1988 10-K.
  4-D    Specimen Warrant Certificate                  Incorporated by reference to Exhibit 4-C
                                                       filed with Amendment No. 2 to the
                                                       Company's Registration Statement on Form
                                                       S-4, Registration No. 33-19647.
  5      Opinion of Streich Lang, P.A. as to the       Page 14
         legality of securities being registered
 23-A    Consent of Deloitte & Touche LLP              Page 16
 23-B    Consent of Streich Lang, P.A.                 See Exhibit 5
 24-A    Power of Attorney of James E. Tinnell,        Page 17
         M.D.
 24-B    Power of Attorney of Joseph Hines             Page 18
 24-C    Power of Attorney of Patrick M. Lonergan      Page 19
 24-D    Power of Attorney of Michael S. Lesser        Page 20
 24-E    Power of Attorney of Carl A. Schroeder        Page 21
 24-F    Power of Attorney of H. Ray Cox               Page 22
 24-G    Power of Attorney of Clarence J. Baudhuin     Page 23
</TABLE>
 
ITEM 17.  UNDERTAKINGS
 
     The undersigned registrant hereby undertakes:
 
     (1) To file, during any period in which offers or sales are being made, a
         post-effective amendment to this registration statement:
 
          (i) To include any prospectus required by Section 10(a)(3) of the
     Securities Act of 1933;
 
          (ii) To reflect in the prospectus any facts or events arising after
               the effective date of the registration statement (or the most
               recent post-effective amendment thereof) which, individually or
               in the aggregate, represent a fundamental change in the
               information set forth in the registration statement.
               Notwithstanding the foregoing, any increase or decrease in volume
               of securities offered (if the total dollar value of securities
               offered would not exceed that which was registered) and any
               deviation from the low or high end of the estimated maximum
               offering range may be reflected in the form of prospectus filed
               with the Commission pursuant to Rule 424(b) if, in the aggregate,
               the changes in volume and price represent no more than a 20%
               change in the maximum aggregate offering price set forth in the
               "Calculation of Registration Fee" table in the effective
               registration statement;
 
          (iii) To include any material information with respect to the plan of
                distribution not previously disclosed in the registration
                statement or any material change to such information in the
                registration statement;
 
        provided, however, That paragraphs (a)(1)(i) and (a)(1)(ii) of this
        section do not apply if the registration statement is on Form S-3, Form
        S-8 or Form F-3, and the information required to be
 
                                      II-2
<PAGE>   12
 
         included in a post-effective amendment by those paragraphs is contained
         in periodic reports filed with or furnished to the Commission by the
         registrant pursuant to Section 13 or 15(d) of the Securities Exchange
         Act of 1934 that are incorporated by reference in the registration
         statement.
 
     (2) That, for the purpose of determining any liability under the Securities
         Act of 1933, each such posteffective amendment shall be deemed to be a
         new registration statement relating to the securities offered therein,
         and the offering of such securities at the time shall be deemed to be
         the initial bona fide offering thereof.
 
     (3) To remove from registration by means of a post-effective amendment any
         of the securities being registered which remain unsold at the
         termination of the offering.
 
     The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to Section 13(a) or 15(d) of the Securities
Exchange Act of 1934 (and, where applicable, each filing of an employee benefit
plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of
1934) that is incorporated by reference in the registration statement shall be
deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.
 
     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of the
registrant pursuant to the provisions described in Item 15 above, or otherwise,
the registrant has been advised that in the opinion of the Securities and
Exchange Commission such indemnification is against public policy as expressed
in the Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.
 
                                      II-3
<PAGE>   13
 
                                   SIGNATURES
 
     Pursuant to the requirements of the Securities Act of 1933, Zila, Inc.
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-3 and has duly caused this Registration
Statement on Form S-3 to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Phoenix and State of Arizona on February 1,
1996.
 
                                          ZILA, INC., a Delaware corporation
 
                                          By    /s/  CLARENCE J. BAUDHUIN
 
                                            ------------------------------------
                                                    Clarence J. Baudhuin
                                            Executive Vice President of Finance
                                                             and
                                               Administration, Treasurer and
                                                          Director
                                            (Principal Financial and Accounting
                                                          Officer)
 
     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the date indicated.
 
<TABLE>
<CAPTION>
              SIGNATURE                                TITLE                        DATE
- -------------------------------------  -------------------------------------  -----------------
<S>                                    <C>                                    <C>
                  *                    Chairman of the Board, President,       February 1, 1996
- -------------------------------------    Chief Executive Officer
            Joseph Hines
      /s/  CLARENCE J. BAUDHUIN        Executive Vice President of Finance     February 1, 1996
- -------------------------------------    and Administration, Treasurer and
        Clarence J. Baudhuin             Director
                  *                    Director                                February 1, 1996
- -------------------------------------
     Dr. James E. Tinnell, M.D.
                  *                    Director                                February 1, 1996
- -------------------------------------
         Patrick M. Lonergan
                  *                    Director                                February 1, 1996
- -------------------------------------
          Carl A. Schroeder
                  *                    Director                                February 1, 1996
- -------------------------------------
             H. Ray Cox
                  *                    Director                                February 1, 1996
- -------------------------------------
          Michael S. Lesser
   *By  /s/  CLARENCE J. BAUDHUIN
- -------------------------------------
        Clarence J. Baudhuin
          Attorney-in-Fact
</TABLE>
 
                                       S-1

<PAGE>   1
                          [Letterhead of Streich Lang]
  
February 1, 1996                                        Writer's Direct Line:
                                                               (602) 229-5509
 
Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C. 20549
 
     RE: Zila, Inc.
 
Ladies and Gentlemen:
 
     This firm is counsel for Zila, Inc., a Delaware corporation (the
"Company"). As such, we are familiar with the Certificate of Incorporation and
Bylaws of the Company. We have also acted as counsel for the Company with
respect to certain matters in connection with the preparation of the
Registration Statement on Form S-3 registering 329,655 shares of Common Stock,
$.001 par value (the "Shares") under the Securities Act of 1933. In addition, we
have examined such documents and undertaken such further inquiry as we consider
necessary for rendering the opinion hereinafter set forth below.
 
     Based upon the foregoing, it is our opinion that:
 
     1. The Company is a corporation duly organized and validly existing under
the laws of the Sate of Delaware.
 
     2. The Shares, when issued, will be duly and validly issued, fully paid and
nonassessable.
 
     We acknowledge that we are referred to under the heading "Legal Matters" of
the Prospectus which is part of the Registration Statement and we hereby consent
to the use of our name in such Registration Statement. We further consent to the
filing of this opinion as Exhibit 5 to the Registration Statement and with the
state regulatory agencies in such states as may require such filing in
connection with the registration of the Shares for offer and sale in such
states.
 
                                          Very truly yours,
 
                                          /s/  Kevin J. Tourek
 
                                          Kevin J. Tourek
                                          FOR THE FIRM
 
                                   EXHIBIT 5

<PAGE>   1
 
                         INDEPENDENT AUDITORS' CONSENT
 
     We consent to the incorporation by reference in this Registration Statement
of Zila, Inc. on Form S-3 of our reports dated October 12, 1995, appearing in
the Annual Report on Form 10-K of Zila, Inc. for the year ended July 31, 1995
and to the reference to us under the heading "Experts" in the Prospectus, which
is part of this Registration Statement.
 
/s/ DELOITTE & TOUCHE LLP
- ---------------------------------------------------------
Deloitte & Touche LLP
Phoenix, Arizona
 
January 30, 1996
 
                                  EXHIBIT 23-A

<PAGE>   1
 
                                                                    EXHIBIT 24-A
 
                           SPECIAL POWER OF ATTORNEY
 
     KNOW ALL MEN BY THESE PRESENTS, that the undersigned, constitutes and
appoints JOSEPH HINES and CLARENCE J. BAUDHUIN, and each of them, his true and
lawful attorney-in-fact and agent with full power of substitution and
resubstitution, for him and in his name, place and stead, in any and all
capacities, to sign a Form S-3 Registration Statement for filing with the
Securities and Exchange Commission respecting the registration of shares of
Common Stock, $.001 par value, of Zila, Inc., a Delaware corporation, together
with any and all amendments (including post-effective amendments) to such
Registration Statement, and to file the same with all exhibits thereto, and all
documents in connection therewith, with the Securities and Exchange Commission,
granting such attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and necessary
to be done in and about the premises, as fully and to all intents and purposes
as he might or could do in person, hereby ratifying and confirming all that such
attorneys-in-fact and agents, or each of them, may lawfully do or cause to be
done by virtue hereof.
 
DATED: January 23, 1996
 
                                              /s/  DR. JAMES E. TINNELL
 
                                          --------------------------------------
                                                   DR. JAMES E. TINNELL
STATE OF Arizona
                           ss.
County of Maricopa
 
     On this 23rd day of January, 1996, before me, the undersigned Notary
Public, personally appeared Dr James E Tinnerl, known to me to be the person
whose name is subscribed to the within instrument and acknowledged that he
executed the same for the purposes therein contained.
 
     IN WITNESS WHEREOF, I hereunto set my hand and official seal.
 
                                                 /s/  JANICE BACKUS
 
                                          --------------------------------------
                                                      Notary Public
 
My commission expires:
 
October 23, 1997

<PAGE>   1
 
                                                                    EXHIBIT 24-B
 
                           SPECIAL POWER OF ATTORNEY
 
     KNOW ALL MEN BY THESE PRESENTS, that the undersigned, constitutes and
appoints CLARENCE J. BAUDHUIN his true and lawful attorney-in-fact and agent
with full power of substitution and resubstitution, for him and in his name,
place and stead, in any and all capacities, to sign a Form S-3 Registration
Statement for filing with the Securities and Exchange Commission respecting the
registration of shares of Common Stock, $.001 par value, of Zila, Inc., a
Delaware corporation, together with any and all amendments (including
post-effective amendments) to such Registration Statement, and to file the same
with all exhibits thereto, and all documents in connection therewith, with the
Securities and Exchange Commission, granting such attorney-in-fact and agent
full power and authority to do and perform each and every act and thing
requisite and necessary to be done in and about the premises, as fully and to
all intents and purposes as he might or could do in person, hereby ratifying and
confirming all that such attorney-in-fact and agent may lawfully do or cause to
be done by virtue hereof.
 
DATED: January 23, 1996
 
                                                  /s/  JOSEPH HINES
 
                                          --------------------------------------
                                                       JOSEPH HINES
STATE OF Arizona
                           ss.
County of Maricopa
 
     On this 23rd day of January, 1996, before me, the undersigned Notary
Public, personally appeared Joseph Hines, known to me to be the person whose
name is subscribed to the within instrument and acknowledged that he executed
the same for the purposes therein contained.
 
     IN WITNESS WHEREOF, I hereunto set my hand and official seal.
 
                                                 /s/  JANICE BACKUS
 
                                          --------------------------------------
                                                      Notary Public
 
My commission expires:
 
October 23, 1997

<PAGE>   1
 
                                                                    EXHIBIT 24-C
 
                           SPECIAL POWER OF ATTORNEY
 
     KNOW ALL MEN BY THESE PRESENTS, that the undersigned, constitutes and
appoints JOSEPH HINES and CLARENCE J. BAUDHUIN, and each of them, his true and
lawful attorney-in-fact and agent with full power of substitution and
resubstitution, for him and in his name, place and stead, in any and all
capacities, to sign a Form S-3 Registration Statement for filing with the
Securities and Exchange Commission respecting the registration of shares of
Common Stock, $.001 par value, of Zila, Inc., a Delaware corporation, together
with any and all amendments (including post-effective amendments) to such
Registration Statement, and to file the same with all exhibits thereto, and all
documents in connection therewith, with the Securities and Exchange Commission,
granting such attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and necessary
to be done in and about the premises, as fully and to all intents and purposes
as he might or could do in person, hereby ratifying and confirming all that such
attorneys-in-fact and agents, or each of them, may lawfully do or cause to be
done by virtue hereof.
 
DATED: January 22, 1996
 
                                              /s/  PATRICK M. LONERGAN
 
                                          --------------------------------------
                                                   PATRICK M. LONERGAN
STATE OF NEW JERSEY
                                    ss.
County of Middlesex
 
     On this 22nd day of January, 1996, before me, the undersigned Notary
Public, personally appeared Patrick M. Lonergan, known to me to be the person
whose name is subscribed to the within instrument and acknowledged that he
executed the same for the purposes therein contained.
 
     IN WITNESS WHEREOF, I hereunto set my hand and official seal.
 
                                             /s/  CHERYL CHRISTINE MOCK
 
                                          --------------------------------------
                                                      Notary Public
 
My commission expires:
 
July 10, 1996

<PAGE>   1
 
                                                                    EXHIBIT 24-D
 
                           SPECIAL POWER OF ATTORNEY
 
     KNOW ALL MEN BY THESE PRESENTS, that the undersigned, constitutes and
appoints JOSEPH HINES and CLARENCE J. BAUDHUIN, and each of them, his true and
lawful attorney-in-fact and agent with full power of substitution and
resubstitution, for him and in his name, place and stead, in any and all
capacities, to sign a Form S-3 Registration Statement for filing with the
Securities and Exchange Commission respecting the registration of shares of
Common Stock, $.001 par value, of Zila, Inc., a Delaware corporation, together
with any and all amendments (including post-effective amendments) to such
Registration Statement, and to file the same with all exhibits thereto, and all
documents in connection therewith, with the Securities and Exchange Commission,
granting such attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and necessary
to be done in and about the premises, as fully and to all intents and purposes
as he might or could do in person, hereby ratifying and confirming all that such
attorneys-in-fact and agents, or each of them, may lawfully do or cause to be
done by virtue hereof.
 
DATED: January 22, 1996
 
                                               /s/  MICHAEL S. LESSER
 
                                          --------------------------------------
                                                    MICHAEL S. LESSER
STATE OF New Jersey
                                    ss.
County of Morris
 
     On this 22nd day of January, 1996, before me, the undersigned Notary
Public, personally appeared Michael Lesser, known to me to be the person whose
name is subscribed to the within instrument and acknowledged that he executed
the same for the purposes therein contained.
 
     IN WITNESS WHEREOF, I hereunto set my hand and official seal.
 
                                                /s/  KATHLEEN BEGLEY
 
                                          --------------------------------------
                                                      Notary Public
My commission expires:
 
July 24, 2000

<PAGE>   1
 
                                                                    EXHIBIT 24-E
 
                           SPECIAL POWER OF ATTORNEY
 
     KNOW ALL MEN BY THESE PRESENTS, that the undersigned, constitutes and
appoints JOSEPH HINES and CLARENCE J. BAUDHUIN, and each of them, his true and
lawful attorney-in-fact and agent with full power of substitution and
resubstitution, for him and in his name, place and stead, in any and all
capacities, to sign a Form S-3 Registration Statement for filing with the
Securities and Exchange Commission respecting the registration of shares of
Common Stock, $.001 par value, of Zila, Inc., a Delaware corporation, together
with any and all amendments (including post-effective amendments) to such
Registration Statement, and to file the same with all exhibits thereto, and all
documents in connection therewith, with the Securities and Exchange Commission,
granting such attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and necessary
to be done in and about the premises, as fully and to all intents and purposes
as he might or could do in person, hereby ratifying and confirming all that such
attorneys-in-fact and agents, or each of them, may lawfully do or cause to be
done by virtue hereof.
 
DATED: January 23, 1996
 
                                               /s/  CARL A. SCHROEDER
 
                                          --------------------------------------
                                                    CARL A. SCHROEDER
STATE OF Arizona
                              ss.
County of MARICOPA
 
     On this 23rd day of January, 1996, before me, the undersigned Notary
Public, personally appeared Carl A. Schroeder, known to me to be the person
whose name is subscribed to the within instrument and acknowledged that he
executed the same for the purposes therein contained.
 
     IN WITNESS WHEREOF, I hereunto set my hand and official seal.
 
                                                 /s/  JANICE BACKUS
 
                                          --------------------------------------
                                                      Notary Public
 
My commission expires:
 
October 23, 1997

<PAGE>   1
 
                                                                    EXHIBIT 24-F
 
                           SPECIAL POWER OF ATTORNEY
 
     KNOW ALL MEN BY THESE PRESENTS, that the undersigned, constitutes and
appoints JOSEPH HINES and CLARENCE J. BAUDHUIN, and each of them, his true and
lawful attorney-in-fact and agent with full power of substitution and
resubstitution, for him and in his name, place and stead, in any and all
capacities, to sign a Form S-3 Registration Statement for filing with the
Securities and Exchange Commission respecting the registration of shares of
Common Stock, $.001 par value, of Zila, Inc., a Delaware corporation, together
with any and all amendments (including post-effective amendments) to such
Registration Statement, and to file the same with all exhibits thereto, and all
documents in connection therewith, with the Securities and Exchange Commission,
granting such attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and necessary
to be done in and about the premises, as fully and to all intents and purposes
as he might or could do in person, hereby ratifying and confirming all that such
attorneys-in-fact and agents, or each of them, may lawfully do or cause to be
done by virtue hereof.
 
DATED: January 23, 1996
 
                                                   /s/  H. RAY COX
 
                                          --------------------------------------
                                                        H. RAY COX
STATE OF ARIZONA
                              ss.
County of MARICOPA
 
     On this 23rd day of January, 1996, before me, the undersigned Notary
Public, personally appeared H. Ray Cox, known to me to be the person whose name
is subscribed to the within instrument and acknowledged that he executed the
same for the purposes therein contained.
 
     IN WITNESS WHEREOF, I hereunto set my hand and official seal.
 
                                                 /s/  JANICE BACKUS
 
                                          --------------------------------------
                                                      Notary Public
 
My commission expires:
 
October 23, 1997

<PAGE>   1
 
                                                                    EXHIBIT 24-G
 
                           SPECIAL POWER OF ATTORNEY
 
     KNOW ALL MEN BY THESE PRESENTS, that the undersigned, constitutes and
appoints JOSEPH HINES his true and lawful attorney-in-fact and agent with full
power of substitution and resubstitution, for him and in his name, place and
stead, in any and all capacities, to sign a Form S-3 Registration Statement for
filing with the Securities and Exchange Commission respecting the registration
of shares of Common Stock, $.001 par value, of Zila, Inc., a Delaware
corporation, together with any and all amendments (including post-effective
amendments) to such Registration Statement, and to file the same with all
exhibits thereto, and all documents in connection therewith, with the Securities
and Exchange Commission, granting such attorney-in-fact and agent full power and
authority to do and perform each and every act and thing requisite and necessary
to be done in and about the premises, as fully and to all intents and purposes
as he might or could do in person, hereby ratifying and confirming all that such
attorney-in-fact and agent may lawfully do or cause to be done by virtue hereof.
 
DATED: January 23, 1996
 
                                              /s/  CLARENCE J. BAUDHUIN
 
                                          --------------------------------------
                                                   CLARENCE J. BAUDHUIN
STATE OF Arizona
                              ss.
County of Maricopa
 
     On this 23rd day of January, 1996, before me, the undersigned Notary
Public, personally appeared Clarence J. Baudhuin, known to me to be the person
whose name is subscribed to the within instrument and acknowledged that he
executed the same for the purposes therein contained.
 
     IN WITNESS WHEREOF, I hereunto set my hand and official seal.
 
                                                 /s/  JANICE BACKUS
 
                                          --------------------------------------
                                                      Notary Public
 
My commission expires:
 
October 23, 1997


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