ADVANCED TISSUE SCIENCES INC
8-K, 1995-07-20
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>
                     SECURITIES AND EXCHANGE COMMISSION
                          Washington, D.C. 20549


                                 FORM 8-K
                             -----------------



                                CURRENT REPORT

 Pursuant to Section 13 or 15(d) of the Securities and Exchange Act of 1934


                                July 7, 1995
                               Date of Report
                      (Date of earliest event reported)


                             -----------------


                      ADVANCED TISSUE SCIENCES, INC.
           (Exact name of registrant as specified in its charter)

                             -----------------



          Delaware                    0-016607           14-1701513
        ------------                ------------       --------------
(State or other jurisdiction of     (Commission       (I.R.S. Employer
 incorporation or organization)       File No.)      Identification No.)


  10933 North Torrey Pines Road, La Jolla, California        92037
  ---------------------------------------------------        -----
       (Address of principal executive offices)           (Zip Code)


    Registrant's telephone number, including area code:  (619) 450-5730





<PAGE>

Item 5.  Other Events

Advanced Tissue Sciences, Inc. (the "Company") completed a series private 
placements on June 26, 1995, July 7, 1995 and July 12, 1995, issuing a 
total of 2,614,432 shares of Common Stock and raising total gross proceeds 
of approximately $18 million. The Company intends to use the proceeds from 
these offerings to complete the validation of its manufacturing facility, 
the up-scaling and validation of its manufacturing processes for 
Dermagraft-TC trademark for the treatment of severe burns and Dermagraft 
trademark for the treatment of diabetic foot ulcers, and other working capital 
and general corporate purposes.  The June 26, 1995 private placements were 
reported on a Current Report on Form 8-K dated June 26, 1995.  The July 7, 
1995 and July 12, 1995 private placements are summarized below.

JULY 7, 1995 PRIVATE PLACEMENT

On July 7, 1995, the Company completed the private placement of 728,863 
shares of its Common Stock (the "7/7/95 Shares") pursuant to Regulation D 
to the Securities Act of 1933, yielding the Company gross proceeds of 
approximately $5.0 million.  The initial purchase price for the 7/7/95 
Shares was $6.86 per share, representing an 11.5% discount to the closing 
bid price of the Company's Common Stock on June 7, 1995.  However, the 
initial purchase price will be adjusted to result in a purchase price per 
share to the investors equal to 88.5% of the average closing price of the 
Common Stock during a period 115 to 160 calendar days after June 26, 1995 
(the "7/7/95 Average Price").  To the extent 88.5% of the 7/7/95 Average 
Price exceeds the initial purchase price of $6.86, the investor will 
provide additional proceeds such that the total proceeds to the Company 
from the investor equals the product of the 88.5% of the 7/7/95 Average 
Price and the 7/7/95 Shares.  If 88.5% of the 7/7/95 Average Price is below 
the initial purchase price of $6.86, additional shares will be issued to 
the investor such that the purchase per share to the investor equals 88.5% 
of the 7/7/95 Average Price.

In addition, if 88.5% of the 7/7/95 Average Price is less than $6.86 per 
share and the Company issues or sells any shares of its Common Stock or any 
of its securities which are convertible into or exchangeable for its Common 
Stock or any warrants, options or other rights to subscribe for or purchase 
Common Stock within 160 calendar days after June 26, 1995 at a purchase 
price less than $6.86 per share, then additional shares will be issued to 
result in a purchase price per share to the investor equal to the lower of 
(i) 88.5% of the 7/7/95 Average Price or (ii) the lowest price per share 
the Company issues or sells any of the securities referred to above.  This 
adjustment is exclusive of shares or options issued pursuant to the 
Company's option plans or shares issued upon the exercise of options, 
warrants or rights outstanding on the closing date of the transaction.

The 7/7/95 Shares have not been registered under the Securities Act of 1933 
or applicable state securities laws, and may not be offered or sold in the 
United States absent registration under such Act and applicable state 
securities laws or in reliance on available exemptions from such 
registration requirements.  However, the investor has certain registration 
rights, including agreement by the Company to register the 7/7/95 Shares 
within 105 calendar days of June 26, 1995 (by October 9, 1995).

The Investment Agreement between the Company and Kyneton Investments Ltd. 
dated July 5, 1995 is attached hereto as an exhibit and is incorporated 
herein by reference.  The foregoing summary is qualified in its entirety by 
reference to such exhibit.

In connection with the offering, the Company also issued warrants (the 
"7/7/95 Warrants") to purchase 51,750 and 13,848 shares, respectively, to 
designees of Cappello Capital Corp. ("Cappello") and The Kriegsman Group 
("Kriegsman").  Cappello acted as a financial advisor to the Company and 
Kriegsman as a finder with respect to the offering.  Cappello also received 
a cash commission and Kriegsman a finder's fee.  The 7/7/95 Warrants are 
subject to adjustment in the same manner as the 7/7/95 Shares.  In 
addition, Cappello and Kriegsman have certain piggyback registration rights 
related to the 7/7/95 Warrants.

                                 -1-

<PAGE>
Item 5.  Other Events (Continued)

JULY 12, 1995 PRIVATE PLACEMENT

     On July 12, 1995, the Company completed the private placement of 
385,569 shares of its Common Stock (the "7/12/95 Shares") pursuant to 
Regulation D to the Securities Act of 1933, yielding the Company gross 
proceeds of approximately $2.6 million.  The initial purchase price for the 
7/12/95 Shares was $6.86 per share, representing an 11.5% discount to the 
closing bid price of the Company's Common Stock on June 7, 1995.  However, 
the initial purchase price will be adjusted to result in a purchase price 
per share to the investors equal to 88.5% of the average closing price of 
the Common Stock during a period 160 to 205 calendar days after June 26, 
1995 (the "7/12/95 Average Price").  To the extent 88.5% of the 7/12/95 
Average Price exceeds the initial purchase price of $6.86, the investor 
will provide additional proceeds such that the total proceeds to the 
Company from the investor equals the product of the 88.5% of the 7/12/95 
Average Price and the 7/12/95 Shares.  If 88.5% of the 7/12/95 Average 
Price is below the initial purchase price of $6.86, additional shares will 
be issued to the investor such that the purchase per share to the investor 
equals 88.5% of the 7/12/95 Average Price.

In addition, if 88.5% of the 7/12/95 Average Price is less than $6.86 per 
share and the Company issues or sells any shares of its Common Stock or any 
of its securities which are convertible into or exchangeable for its Common 
Stock or any warrants, options or other rights to subscribe for or purchase 
Common Stock within 205 calendar days from June 26, 1995 at a purchase 
price less than $6.86 per share, then additional shares will be issued to 
result in a purchase price per share to the investor equal to the lower of 
(i) 88.5% of the 7/12/95 Average Price or (ii) the lowest price per share 
the Company issues or sells any of the securities referred to above.  This 
adjustment is exclusive of shares or options issued pursuant to the 
Company's option plans or shares issued upon the exercise of options, 
warrants or rights outstanding on the closing date of the transaction.

The 7/12/95 Shares have not been registered under the Securities Act of 
1933 or applicable state securities laws, and may not be offered or sold in 
the United States absent registration under such Act and applicable state 
securities laws or in reliance on available exemptions from such 
registration requirements.  However, the investor has certain registration 
rights, including agreement by the Company to register the 7/12/95 Shares 
within 160 calendar days of June 26, 1995 (by December 3, 1995).  In the 
event the registration is not effective with the 160-day period, the 
purchase price per share will be determined, where applicable, using 77% 
rather than 88.5% of the 7/12/95 Average Price.

The Investment Agreement between the Company and Arbco Associates, L.P. and 
Offense Group Associates, L.P. dated July 11, 1995 is attached hereto as an 
exhibit and is incorporated herein by reference.  The foregoing summary is 
qualified in its entirety by reference to such exhibit.

In connection with the offering, the Company also issued warrants (the 
"7/12/95 Warrants") to purchase 23,134 and 11,567 shares, respectively, to 
designees of Cappello and Kriegsman.  Cappello acted as a financial advisor 
to the Company and Kriegsman as a finder with respect to the offering.  
Cappello also received a cash commission and Kriegsman a finder's fee.  The 
7/12/95 Warrants are subject to adjustment in the same manner as the 
7/12/95 Shares.  In addition, Cappello and Kriegsman have certain piggyback 
registration rights related to the 7/12/95 Warrants.

                                   -2-

<PAGE>


Item 7.  Exhibits


Exhibit                                                    Method
 Number                 Description                      of Filing
- -------                 -----------                      ---------

  4.1     Investment Agreement between Advanced       Filed Herewith
          Tissue Sciences, Inc. and Kyneton 
          Investments Ltd.. dated July 5, 1995

  4.2     Investment Agreement between Advanced       Filed Herewith
          Tissue Sciences, Inc. and Arbco 
          Associates, L.P. and Offense Group 
          Associates, L.P. dated July 11, 1995

  4.3     Form of Warrant Agreement between the       Incorporated by
          Company and each of Linda S. Cappello,       Reference to
          Gerard K. Cappello, Lawrence K. Fleischman   Exhibit 4.4 to
          and The Kriegsman Group                      the Registrant's
                                                       Current Report on
                                                       Form 8-K dated 
                                                       June 26, 1995



                                SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, 
the registrant has duly caused this report to be signed on its behalf by 
the undersigned hereunto duly authorized.


                                  ADVANCED TISSUE SCIENCES, INC.


Date:  July 19, 1995              By: /s/ Arthur J. Benvenuto
                                      ----------------------------
                                      Arthur J. Benvenuto
                                      Chairman, President and 
                                      Chief Executive Officer



                                 -3-
<PAGE>


EXHIBIT INDEX


Exhibit
 Number              Description                               Page
- -------              -----------                               ----

  4.1     Investment Agreement between Advanced Tissue 
          Sciences, Inc. and Kyneton Investments Ltd.. 
          dated July 5, 1995

  4.2     Investment Agreement between Advanced Tissue
          Sciences, Inc. and Arbco Associates, L.P. and 
          Offense Group Associates, L.P. dated July 11, 1995

  4.3     Form of Warrant Agreement between the Company and 
          each of Linda S. Cappello, Gerard K. Cappello, 
          Lawrence K. Fleischman and The Kriegsman Group








<PAGE>
                                                            EXHIBIT 4.1

                          INVESTMENT AGREEMENT


                                 Between



                     ADVANCED TISSUE SCIENCES, INC.



                                   And


                        KYNETON INVESTMENTS LTD.




                        Dated as of July 5, 1995







            The securities to be purchased and sold pursuant to this
            Investment Agreement have not been registered under the 
            Securities Act of 1933, as amended, (the "Act") or any state 
            securities laws.  They may not be offered or sold in the 
            absence of an effective registration statement as to the 
            securities under said Act and any applicable State 
            securities law or an applicable exemption from the 
            registration requirements of the Act.

<PAGE>


      INVESTMENT AGREEMENT dated as of July 5, 1995 between Kyneton 
Investments Ltd., a corporation organized and existing under the laws of 
the Cayman Islands ( the "Investor") and Advanced Tissue Sciences, Inc., 
a corporation organized and existing under the laws of the State of 
Delaware (the "Company").

            WHEREAS, the parties desire that the Investor become an 
equity investor in the Company by purchasing an aggregate of 728,863 
shares of the Company's Common Stock, par value $.01 per share (the 
"Common Stock").

            NOW, THEREFORE, the parties hereto agree as follows:


                                ARTICLE I

                    Purchase and Sale of Common Stock
                    ---------------------------------

            Section 1.1  PURCHASE AND SALE OF COMMON STOCK.  Upon the 
terms and conditions set forth herein, the Company shall issue and sell 
to the Investor, and the Investor shall purchase from the Company, 
728,863 shares of the Company's Common Stock (the "Shares").

            Section 1.2  PURCHASE PRICE.  The aggregate purchase price 
for the Shares (the "Purchase Price") shall equal $5,000,000 payable in 
cash by wire transfer or cashier's check in immediately available funds.

            Section 1.3  SHARE NUMBER; VALUATION PERIOD.

                 (a)  The number of Shares that the Company shall be 
obligated to issue and sell and the Investor shall be obligated to 
purchase hereunder, in the aggregate, is referred to herein as the 
"Share Number."  Subject to adjustment as provided in Sections 1.3(c), 
1.3(d) and 1.3(e), the Share Number shall initially be 728,863.

                 (b)  The "Valuation Period" shall be a 45 calendar day 
period commencing on and including the first business day which is 115 
calendar days after June 26, 1995 as the same may be modified pursuant 
to Section 4.2(c) hereof.

                 (c)  Notwithstanding Section 1.3(a) above, and except 
as hereinafter provided, if the Average Share Price (hereinafter 
defined) during the Valuation Period is less than $7.75, then the 
Company shall deliver to the Investor, at no additional cost to the 
Investor, and in addition to the initial Share Number, the number of 
shares of Common Stock that is obtained by subtracting (x) 728,863 from 
(y) the quotient obtained by dividing the Purchase Price by 88.5% of the 
Average Share Price (rounded to the nearest whole number) (together with 
any additional shares issued pursuant to Section 1.3(e) herein, the 
"Additional Shares").

                 (d)  Notwithstanding Section 1.3(a) above, and except 
as hereinafter provided, if the Average Share Price during the Valuation 
Period is greater than $7.75, the Investor shall pay to the Company the 
dollar amount by which (x) the product of 88.5% of the Average Share 
Price and the Share Number exceeds (y) the product of $6.86 and the 
Share Number.

                 (e)  Notwithstanding Section 1.3(c) above, in the event 
that the Company, on or prior to 160 days from June 26, 1995, issues or 
sells any shares of its Common Stock or any of its 

                                 -2-

<PAGE>

securities which are convertible into or exchangeable for its Common Stock 
or any warrants or other rights to subscribe for or to purchase or any 
options for the purchase of, its Common Stock (other than shares or options 
issued pursuant to the Company's option plans or shares issued upon exercise 
of options, warrants or rights outstanding on the Closing Date or as 
provided on Exhibit A hereto), at a purchase price which is less than 
$6.86 per share (the "Subsequent Sale Price"), then the Company shall 
deliver to the Investor, at no additional cost to the Investor, and in 
addition to the Share Number, the number of shares of Common Stock that 
is obtained by subtracting (x) 728,863 from (y) the quotient obtained by 
dividing the Purchase Price by the Subsequent Sale Price (rounded to the 
nearest whole number).  The "Subsequent Sale Price" shall mean the 
effective purchase price of the shares after all adjustments.

                 Notwithstanding any of the foregoing, the number of 
Additional Shares issuable hereunder shall be the greater of the number 
of Additional Shares issuable pursuant to Section 1.3(c) herein and the 
number of Additional Shares issuable pursuant to Section 1.3(e) herein, 
if any.

                 (f)  For purposes hereof, the Average Share Price shall 
mean the average of the closing trading prices of the Company's Common 
Stock on the Nasdaq National Market, as reported by the Nasdaq National 
Market for each trading day during the Valuation Period.

            Section 1.4  THE CLOSING.

                 (a)  The closing of the purchase and sale of the Shares 
(the "Closing"), shall take place (a) at the offices of the Investor, at 
10:00 a.m., local time on the later of the following:  (i) July 5, 1995, 
and (ii) the date on which the last to be fulfilled or waived of the 
conditions set forth in Article IV hereof and applicable to the Closing 
shall be fulfilled or waived in accordance herewith, or (b) at such 
other time and place and/or on such other date as the Investor and the 
Company may agree.  The date on which the Closing occurs is referred to 
herein as the "Closing Date."

                 (b)  (i) On the Closing Date, the Company shall deliver 
to the Investor certificates representing the Share Number to be issued 
and sold to the Investor on such date and registered in the name of the 
Investor or deposit such Share Number into the accounts designated by 
the Investor and (ii) on the Closing Date, the Investor shall deliver to 
the Company the Purchase Price by cashier's check or wire transfer in 
immediately available funds to such account as shall be designated in 
writing by the Company.  In addition, each of the Company and the 
Investor shall deliver all documents, instruments and writings required 
to be delivered by either of them pursuant to this Agreement at or prior 
to the Closing.

            Section 1.5.  COVENANT TO REGISTER.  For purposes of this 
Section 1.5, the following definitions shall apply:

                 (a)  (i)  The terms "register," "registered," and 
"registration" refer to a registration under the Securities Act of 1933, 
as amended (the "Act") effected by preparing and filing a registration 
statement or similar document in compliance with the Act, and the 
declaration or ordering of effectiveness of such registration statement, 
document or amendment thereto.

                     (ii)  The term "Registrable Securities" means the 
Shares and any Additional Shares issued pursuant to Section 1.3 hereof 
and any securities of the Company or securities of any successor 
corporation issued as, or issuable upon the conversion or exercise of 
any warrant, right or other security that is issued as a dividend or 
other distribution with respect to, or in exchange for, or in 
replacement of, the Shares and any Additional Shares issued pursuant to 
Section 1.3 hereof.

                                  -3-

<PAGE>

                 (b)  (i)  The Company shall, as expeditiously as 
possible following the Closing, file a registration statement on Form S-
3 or an equivalent thereof with the Securities and Exchange Commission 
(the "SEC") promptly after the Closing Date, covering all the 
Registrable Securities, and shall use its best efforts to cause such 
registration statement to become effective within 105 days of June 26, 
1995 (the "Initial Registration").  In the event such registration is 
not so declared effective, the holder of the Registrable Securities 
shall have the right to require by notice in writing that the Company 
register all or any part of the Registrable Securities held by such 
holder (a "Demand Registration") and the Company shall thereupon effect 
such registration in accordance herewith.  The parties agree that if the 
holder of Registrable Securities demands registration of less than all 
of the Registrable Securities, the Company, at its option, may 
nevertheless file a registration statement covering all of the 
Registrable Securities.  If such registration statement is declared 
effective with respect to all Registrable Securities the demand 
registration rights granted pursuant to this Section 1.5 (b) (i) shall 
cease.  If such registration statement is not declared effective with 
respect to all Registrable Securities the demand registration rights 
described herein shall remain in effect until all Registrable Securities 
have been registered under the Act.

                     (ii)  The Company shall not be obligated to effect 
Demand Registration (i) if all of the Registrable Securities held by the 
holder of Registrable Securities which are intended to be covered by the 
Demand Registration are, at the time of the request of a Demand 
Registration, included in an effective registration statement and the 
Company is in compliance with its obligations under Subsection (d) (ii) 
through (v) hereof.

                     (iii)  The Company may suspend the effectiveness of 
any such registration effected pursuant to this Section 1.5(b) in the 
event, and for such period of time as, such a suspension is required by 
the rules and regulations of the SEC.

                     (iv)  If the registration statement covering the 
Registrable Securities is not effective within 105 days of June 26, 
1995, then the Company shall pay the Investor a one time penalty, in 
cash, equal to 1.0% of the Purchase Price but the Company's obligation 
to register the Registrable Securities shall not be diminished.

                 (c)  If the Company proposes to register (including for 
this purpose a registration effected by the Company for shareholders 
other than the Investor) any of its stock or other securities under the 
Act in connection with a public offering of such securities (other than 
a registration on Form S-4, Form S-8 or other limited purpose form) and 
the Registrable Securities have not heretofore been included in a 
registration statement under Subsection (b), which remains effective, 
the Company shall, at such time, promptly give the holder of Registrable 
Securities written notice of such registration.  Upon the written 
request of the holder of Registrable Securities given within twenty (20) 
days after receipt of such notice by the holder of Registrable 
Securities, the Company shall use its best efforts to cause to be 
registered under the Act all Registrable Securities that the holder of 
Registrable Securities requests to be registered.  However, the Company 
shall have no obligation under this Subsection (c) to the extent that, 
with respect to a public offering registration, any underwriter of such 
public offering reasonably requests that the Registrable Securities or a 
portion thereof be excluded therefrom.

                 (d)  Whenever required under this Section 1.5 to effect 
the registration of any Registrable Securities, including, without 
limitation, the Initial Registration, the Company shall, as 
expeditiously as reasonably possible:

                                  -4-

<PAGE>

                     (i)  Prepare and file with the SEC a registration 
statement with respect to such Registrable Securities and use its best 
efforts to cause such registration to become effective and, upon the 
request of the Investor, keep such registration statement effective, 
pursuant to the provisions of Regulation Section 230.415 or otherwise, for 
so long as the holder of Registrable Securities desires to dispose of the 
securities covered by such registration statement (but not after the 
holder of Registrable Securities, in the reasonable opinion of its 
counsel, is free to sell such securities in any three month period under 
the provisions of Rule 144 under the Act).

                     (ii)  Prepare and file with the SEC such amendments 
and supplements to such registration statement and the prospectus used 
in connection with such registration statement as may be necessary to 
comply with the provisions of the Act with respect to the disposition of 
all securities covered by such registration statement.

                     (iii)  Furnish to the holder of Registrable 
Securities such numbers of copies of a prospectus, including a 
preliminary prospectus, in conformity with the requirements of the Act, 
and such other documents as the holder of Registrable Securities may 
reasonably require in order to facilitate the disposition of Registrable 
Securities owned by the holder of Registrable Securities.

                     (iv)  Use its best efforts to register and qualify 
the securities covered by such registration statement under such other 
securities or "Blue Sky" laws of such jurisdictions as shall be 
reasonably requested by the holder of Registrable Securities, provided 
that the Company shall not be required in connection therewith or as a 
condition thereto to qualify to do business or to file a general consent 
to service and process in any such states or jurisdictions.

                     (v)  Notify the holder of Registrable Securities of 
the happening of any event as a result of which the prospectus included 
in such registration statement, as then in effect, includes an untrue 
statement of material fact or omits to state a material fact required to 
be stated therein or necessary to make the statements therein not 
misleading in light of the circumstances then existing.

                     (vi)  Furnish, at the request of the holder of 
Registrable Securities, an opinion of counsel of the Company, dated the 
effective date of the registration statement, as to the due 
authorization and issuance of the securities being registered and 
compliance with securities laws by the Company in connection with the 
authorization and issuance thereof.

                     (vii)  Use its best efforts to list the Registrable 
Securities covered by such registration statement with any securities 
exchange on which the Common Stock is then listed;

                     (viii)  Make available for inspection by the holder 
of Registrable Securities, upon request, all SEC Documents filed 
subsequent to the Closing and require the Company's officers, directors 
and employees to supply all information reasonably requested by any 
holder of Registrable Securities in connection with such registration 
statement.

                 (e)  The holder of Registrable Securities will furnish 
to the Company in connection with any registration under this Section 
1.5 such information regarding itself, the Registrable Securities and 
other securities of the Company held by it, and the intended method of 
disposition of such securities as shall be required to effect the 
registration of the Registrable Securities held by holder of Registrable 
Securities.

                                -5-

<PAGE>

                 (f)  (i)  The Company shall indemnify, defend and hold 
harmless each holder of Registrable Securities which are included in a 
registration statement pursuant to the provisions of Subsections (b) or 
(c) from and against, and shall reimburse such holder with respect to, 
any and all claims, suits, demands, causes of action, losses, damages, 
liabilities, costs or expenses ("Liabilities") to which such holder may 
become subject under the Act or otherwise, arising from or relating to 
(A) any untrue statement or alleged untrue statement of any material 
fact contained in such registration statement, any prospectus contained 
therein or any amendment or supplement thereto, or (B) the omission or 
alleged omission to state therein a material fact required to be stated 
therein or necessary to make the statements therein, in light of the 
circumstances in which they were made, not misleading; provided, 
however, that the Company shall not be liable in any such case to the 
extent that any such Liability arises out of or is based upon an untrue 
statement or alleged untrue statement or omission or alleged omission so 
made in conformity with information furnished by such holders in writing 
specifically for use in the preparation thereof.

                     (ii)  Promptly after receipt by the holder of 
Registrable Securities of notice of the commencement of any action, the 
holder of Registrable Securities shall, if a claim in respect thereof is 
to be made against the Company hereunder, notify the Company in writing 
thereof, but the omission so to notify the Company shall not relieve the 
Company from any Liability which it may have to the holder of 
Registrable Securities other than under this section and shall only 
relieve it from any Liability which it may have to the holder of 
Registrable Securities under this section if and to the extent the 
Company is prejudiced by such omission.  In case any such action shall 
be brought against the holder of Registrable Securities and the holder 
of Registrable Securities shall notify the Company of the commencement 
thereof, the Company shall be entitled to participate in and, to the 
extent it shall wish, to assume and undertake the defense thereof with 
counsel reasonably satisfactory to the holder of Registrable Securities, 
and, after notice from the Company to the holder of Registrable 
Securities of its election so to assume and undertake the defense 
thereof, the Company shall not be liable to the holder of Registrable 
Securities under this section for any legal expenses subsequently 
incurred by the holder of Registrable Securities in connection with the 
defense thereof other than reasonable costs of investigation and of 
liaison with counsel so selected, PROVIDED, HOWEVER, that if the 
defendants in any such action include both the Company and the holder of 
Registrable Securities and the holder of Registrable Securities shall 
have reasonably concluded that there may be reasonable defenses 
available to it which are different from or additional to those 
available to the Company or if the interests of the holder of 
Registrable Securities reasonably may be deemed to conflict with the 
interests of the Company, the holder of Registrable Securities shall 
have the right to select a separate counsel and to assume such legal 
defenses and otherwise to participate in the defense of such action, 
with the expenses and fees of such separate counsel and other expenses 
related to such participation to be reimbursed by the Company as 
incurred.

                 (g)  (i)  With respect to the inclusion of Registrable 
Securities in a registration statement pursuant to subsections (b) or 
(c), all fees, costs and expenses of and incidental to such 
registration, inclusion and public offering shall be borne by the 
Company; provided, however, that any securityholders participating in 
such registration shall bear their pro rata share of the underwriting 
discounts and commissions, if any, incurred in connection with such 
registration.

                     (ii)  The fees, costs and expenses of registration 
to be borne by the Company as provided in this Subsection (g) shall 
include, without limitation, all registration, filing and NASD fees, 
printing expenses, fees and disbursements of counsel and accountants for 
the Company, and all legal fees and disbursements and other expenses of 
complying with state securities or Blue Sky laws of any jurisdiction or 
jurisdictions in which securities to be offered are to be registered and 
qualified.  

                                -6-

<PAGE>

Fees and disbursements of counsel and accountants for the selling security-
holders shall, however, be borne by the respective selling securityholder.

                 (h)  (i)  The rights to cause the Company to register 
all or any portion of Registrable Securities pursuant to this Section 
1.5 may be assigned by Investor to a transferee or assignee of 20% or 
more, in the aggregate, of the Shares and the Additional Shares.  Within 
a reasonable time after such transfer the Investor shall notify the 
Company of the name and address of such transferee or assignee and the 
securities with respect to which such registration rights are being 
assigned.  Such assignment shall be effective only if immediately 
following such transfer the further disposition of such securities by 
the transferee or assignee is restricted under the Act.  Any transferee 
shall agree in writing at the time of transfer to be bound by the 
provisions of this Section 1.5.

                     (ii)  From and after the date of this Agreement, 
the Company shall not agree to allow the holders of any securities of 
the Company to include any of their securities in any registration 
statement filed by the Company pursuant to Subsection (b) unless the 
inclusion of such securities will not reduce the amount of the 
Registrable Securities included therein.

            Section 1.6.  ADJUSTMENTS.  If the Investor shall be 
entitled to the issuance of Additional Shares, the Company shall deliver 
to the Investor at the offices of the Investor on the third (3rd) 
business day after the end of the Valuation Period one or more 
certificates representing the Additional Shares so to be delivered in 
accordance with this Agreement, registered in the name of the Investor, 
or deposit such Additional Shares into accounts designated by the 
Investor; provided, however, that if the sum of the shares then 
beneficially owned by the Investor, and any Additional Shares then 
issuable to the Investor, as determined by the Investor, in its sole 
determination, shall equal 5.0% or more of the shares of Company's 
Common Stock issued and outstanding (as determined in accordance with 
Section 13(d) of the Securities Exchange Act of 1934) just prior to the 
Closing, then, and in such event, (x) the number of Additional Shares to 
be issued to the Investor pursuant to this paragraph shall be reduced to 
the number which, together with the Share Number, shall equal 4.99% of 
the shares of the Company's Common Stock issued and outstanding (as so 
determined) just prior to the Closing, and (y) in consideration for such 
reduction in Additional Shares, the Company shall pay to the Investor a 
sum equal to the greater of (a) the product of 88.5% of the Average 
Share Price and the reduction in the Additional Shares to be issued as a 
result of the preceding clause (x), and (b) the product of the 
Subsequent Sale Price and the reduction in the Additional Shares to be 
issued as a result of the preceding clause (x).

            Section 1.7  RESCHEDULING.  If after the date hereof and 
prior to the expiration of the Valuation Period any person shall (a) 
publicly announce a tender offer or exchange offer for the Company's 
Common Stock, or (b) publicly announce plans for a merger, consolidation 
or potential change in control of the Company, the Investor may in its 
sole discretion elect by written notice to the Company to shorten the 
Valuation Period so as to end on a date which is either before or after 
the consummation of the record date for the consummation of any such 
transaction, which election must be made prior to consummation of any 
such transaction.  For purposes of the foregoing, it is understood and 
agreed that the Investor may, but shall not be required to, reduce or 
entirely eliminate the Valuation Period or to reschedule the Valuation 
Period.

                                   -7-

<PAGE>


                                ARTICLE II

                      Representations and Warranties
                      ------------------------------

            Section 2.1  REPRESENTATIONS AND WARRANTIES OF THE COMPANY.  
The Company hereby makes the following representations and warranties to 
the Investor:

                 (a)  ORGANIZATION AND QUALIFICATION.  The Company is a 
corporation duly incorporated and existing in good standing under the 
laws of the State of Delaware, and has the requisite corporate power to 
own its properties and to carry on its business as now being conducted.  
The Company does not have any active subsidiaries, except for those  
identified in the SEC Documents (as hereinafter defined).  Each of the 
Company and its subsidiaries is duly qualified as a foreign corporation 
to do business and is in good standing in every jurisdiction in which 
the nature of the business conducted or property owned by it makes such 
qualification necessary and where the failure so to qualify would have a 
Material Adverse Effect.  "Material Adverse Effect" means any  adverse 
effect on the operations, properties, prospects, or financial condition 
of the entity with respect to which such term is used and which is 
material to such entity and other entities controlling or controlled by 
such entity taken as a whole.

                 (b)  AUTHORIZATION; ENFORCEMENT.  (i)  The Company has 
the requisite corporate power and authority to enter into and perform 
this Agreement and to issue the Shares and the Additional Shares in 
accordance with the terms hereof, (ii) the execution and delivery of 
this Agreement by the Company and the consummation by it of the 
transactions contemplated hereby have been duly authorized by all 
necessary corporate action, and no further consent or authorization of 
the Company or its Board of Directors or stockholders is required, (iii) 
this Agreement has been duly executed and delivered by the Company, and 
(iv) this Agreement constitutes a valid and binding obligation of the 
Company enforceable against the Company in accordance with its terms, 
except as such enforceability may be limited by applicable bankruptcy, 
insolvency, reorganization, moratorium, liquidation or similar laws 
relating to, or affecting generally the enforcement of, creditors' 
rights and remedies or by other equitable principles of general 
application.

                 (c)  CAPITALIZATION.  The authorized capital stock of 
the Company  and the shares thereof currently issued and outstanding are 
as most recently described in the SEC Documents and there have been no 
changes (except for changes described on Exhibit A and additional option 
exercises under the Company's option plans) therein since such 
description. All of the outstanding shares of the Company's Common Stock 
have been validly issued and are fully paid and nonassessable.  Except 
as set forth in Exhibit A hereto and as described in the SEC Documents, 
no shares of Common Stock are entitled to preemptive rights and there 
are no outstanding options, warrants, scrip, rights to subscribe to, 
calls or commitments of any character whatsoever relating to, or 
securities or rights convertible into, any shares of capital stock of 
the Company, or contracts, commitments, understandings, or arrangements 
by which the Company is or may become bound to issue additional shares 
of capital stock of the Company or options, warrants, scrip, rights to 
subscribe to, or commitments to purchase or acquire, any shares, or 
securities or rights convertible into shares, of capital stock of the 
Company.  The Company has furnished to the Investor true and correct 
copies of the Company's Certificate of Incorporation as in effect on the 
date hereof (the "Certificate"), and the Company's By-Laws, as in effect 
on the date hereof (the "By-Laws").

                 (d)  ISSUANCE OF SHARES.  The issuance of the Shares 
and Additional Shares has been duly authorized and, when paid for or 
issued in accordance with the terms hereof, shall be validly issued, 
fully paid and non-assessable.

                                   -8-

<PAGE>

                 (e)  NO CONFLICTS.  The execution, delivery and 
performance of this Agreement by the Company and the consummation by the 
Company of the transactions contemplated hereby do not and will not (i) 
result in a violation of the Company's Certificate or By-Laws or (ii) 
conflict with, or constitute a default (or an event which with notice or 
lapse of time or both would become a default) under, or give to others 
any rights of termination, amendment, acceleration or cancellation of, 
any agreement, indenture or instrument to which the Company is a party 
and which has previously been filed as an exhibit to the Company's Form 
10-K for the year ended December 31, 1994 or any material agreement 
entered into subsequent thereto and is still in effect, or result in a 
violation of any federal, state, local or foreign law, rule, regulation, 
order, judgment or decree (including Federal and state securities laws 
and regulations) applicable to the Company, or by which any property or 
asset of the Company is bound or affected (except for such conflicts, 
defaults, terminations, amendments, accelerations, cancellations and 
violations as would not, individually or in the aggregate, have a 
Material Adverse Effect); provided that, for purposes of such 
representation as to Federal, state, local or foreign law, rule or 
regulation, no representation is made herein with respect to any of the 
same applicable solely to the Investor and not to the Company.  The 
business of the Company is not being conducted in violation of any law, 
ordinance or regulations of any governmental entity, except for possible 
violations which either singly or in the aggregate do not have a 
Material Adverse Effect.  The Company is not required under Federal, 
state or local law, rule or regulation in the United States to obtain 
any consent, authorization or order of, or make any filing or 
registration with, any court or governmental agency in order for it to 
execute, deliver or perform any of its obligations under this Agreement 
or issue and sell the Shares or the Additional Shares in accordance with 
the terms hereof (other than the filing of a Form D with the SEC, any 
filings required by the National Association of Securities Dealers, Inc. 
or their affiliated exchanges (the "NASD") or state securities filings 
which may be required to be made by the Company subsequent to the 
Closing, and any registration statement which may be filed in accordance 
with Section 1.5 herein); provided that, for purposes of the 
representation made in this sentence, the Company is assuming and 
relying upon the accuracy of the relevant representations and agreements 
of the Investor herein.

                 (f)  SEC DOCUMENTS, FINANCIAL STATEMENTS.  The Common 
Stock of the Company is registered pursuant to Section 12(g) of the 
Securities and Exchange Act of 1934, as amended (the "Exchange Act") and 
the Company has filed all reports, schedules, forms, statements and 
other documents required to be filed by it with the SEC pursuant to the 
reporting requirements of the Exchange Act, including material filed 
pursuant to Section 13(a) or 15(d), in addition to one or more 
registration statements and amendments thereto heretofore filed by the 
Company with the SEC (all of the foregoing filed prior to the date 
hereof, as well as the draft of the Form 8-K with respect to the private 
placement of June 26, 1995, being hereinafter referred to herein as the 
"SEC Documents").  The Company has delivered to the Investor true and 
complete copies of the quarterly and annual (including, without 
limitation, proxy information and solicitation materials) SEC Documents 
filed with the SEC since December 31, 1994.  The Company has not 
provided to the Investor any information which, according to applicable 
law, rule or regulation, should have been disclosed publicly by the 
Company but which has not been so disclosed, other than with respect to 
the transactions contemplated by this Agreement.  As of their respective 
dates, the SEC Documents complied in all material respects with the 
requirements of the Exchange Act and the rules and regulations of the 
SEC promulgated thereunder and other federal, state and local laws, 
rules and regulations applicable to such SEC Documents, and none of the 
SEC Documents contained any untrue statement of a material fact or 
omitted to state a material fact required to be stated therein or 
necessary in order to make the statements therein, in light of the 
circumstances under which they were made, not misleading.  The financial 
statements of the Company included in the SEC Documents comply as to 
form in all material respects with applicable accounting requirements 
and the published rules and regulations of the SEC or other applicable 
rules and 

                                 -9-

<PAGE>

regulations with respect thereto.  Such financial statements have been 
prepared in accordance with generally accepted accounting principles applied 
on a consistent basis during the periods involved (except (i) as may be 
otherwise indicated in such financial statements or the notes thereto or 
(ii) in the case of unaudited interim statements, to the extent they may not 
include footnotes or may be condensed or summary statements) and fairly 
present in all material respects the financial position of the Company as of 
the dates thereof and the results of operations and cash flows for the 
periods then ended (subject, in the case of unaudited statements, to normal 
year-end audit adjustments).

                 (g)  NO MATERIAL ADVERSE CHANGE.  Since December 31, 
1994,  the date through which the most recent annual report of the 
Company on Form 10-K has been prepared and filed with the SEC, a copy of 
which is included in the SEC Documents, no Material Adverse Effect has  
occurred or exists with respect to the Company except as otherwise 
disclosed or reflected in other SEC Documents prepared through or as of 
a date subsequent to December 31, 1994.

                 (h)  NO UNDISCLOSED LIABILITIES.  The Company has no 
liabilities or obligations not disclosed in the SEC Documents, other 
than those incurred in the ordinary course of the Company's business 
since March 31, 1995 and which, individually or in the aggregate, do not 
or would not have a Material Adverse Effect on the Company.

                 (i)  NO UNDISCLOSED EVENTS OR CIRCUMSTANCES.  No event 
or circumstance has occurred or exists with respect to the Company or 
its business, properties, prospects, operations or financial condition, 
which, under applicable law, rule or regulation, requires public 
disclosure or announcement by the Company but which has not been so 
publicly announced or disclosed.

            Section 2.2  REPRESENTATIONS AND WARRANTIES OF THE INVESTOR.  
The Investor hereby makes the following representations and warranties 
to the Company:

                 (a)  AUTHORIZATION; ENFORCEMENT.  (i)  The Investor has 
the requisite power and authority to enter into and perform this 
Agreement and to purchase the Shares being sold hereunder, (ii) the 
execution and delivery of this Agreement by the Investor and the 
consummation by it of the transactions contemplated hereby have been 
duly authorized by all necessary corporate action, and no further 
consent or authorization of the Investor or its Board of Directors, 
stockholders, or partners as the case may be, is required, (iii) this 
Agreement has been duly authorized, executed and delivered by the 
Investor, and (iv) this Agreement constitutes a valid and binding 
obligation of the Investor enforceable against the Investor in 
accordance with its terms, except as enforceability may be limited by 
applicable bankruptcy, insolvency, reorganization, moratorium, 
liquidation or similar laws relating to, or affecting generally the 
enforcement of, creditors' rights and remedies or by other equitable 
principles of general application.

                 (b)  NO CONFLICTS.  The execution, delivery and 
performance of this Agreement and the consummation by the Investor of 
the transactions contemplated hereby or relating hereto do not and will 
not (i) result in a violation of the Investor's charter documents or By-
Laws or (ii) conflict with, or constitute a default (or an event which 
with notice or lapse of time or both would become a default) under, or 
give to others any rights of termination, amendment, acceleration or 
cancellation of any agreement, indenture or instrument to which the 
Investor is a party, or result in a violation of any law, rule, or 
regulation, or any order, judgment or decree of any court or 
governmental agency applicable to the Investor or its properties (except 
for such conflicts, defaults and violations as would not, individually  
or in the aggregate have a Material Adverse Effect on the Investor).  
The businesses of the Investor are not being conducted in violation of 
any law, ordinance or regulation of any governmental entity, except for 
possible violations which either singly or in the aggregate do not 

                                   -10-

<PAGE>

have a Material Adverse Effect.  The Investor is not required to obtain any 
consent, authorization or order of, or make any filing or registration 
with, any court or governmental agency in order for it to execute, 
deliver or perform any of its obligations under this Agreement or 
purchase the Shares or the Additional Shares in accordance with the 
terms hereof; provided that for purposes of the representation made in 
this sentence, the Investor is assuming and relying upon the accuracy of 
the relevant representations and agreements of the Company herein.

                 (c)  OWNERSHIP. The Investor is duly organized and 
validly existing under the laws of the place hereinabove provided and is 
not a U.S. Person as defined within Regulation S under the Act and is 
not purchasing the Shares for the account or benefit of a U.S. Person.  
On the date hereof and on the Closing Date, the Investor is and will be, 
as the case may be, located outside of the United States.  The Investor 
has such knowledge and experience in financial and business matters that 
it is capable of evaluating the merits and risks of the investment 
contemplated by this Agreement.  The Investor has been afforded, to the 
satisfaction of the Investor, the opportunity to review the SEC 
Documents and obtain such additional publicly available information 
concerning the Company and its business, and to ask such questions and 
receive such answers (based upon publicly available information), as the 
Investor deems necessary to make an informed investment decision.

                 (d)  INVESTMENT REPRESENTATION:  The Investor is 
purchasing the Shares and, if any, the Additional Shares for investment 
purposes and not with a view towards distribution.  Investor has no 
present intention to sell the Shares or the Additional Shares and the 
Investor has no present arrangement (whether or not legally binding) at 
any time to sell the Shares or the Additional Shares to or through any 
person or entity; provided, however, except as provided in subsection 
(g) below, that by making the representations herein, the Investor does 
not agree to hold the Shares or the Additional Shares for any minimum or 
other specific term and reserves the right to dispose of the Shares or 
the Additional Shares at any time in accordance with Federal and state 
securities laws applicable to such disposition.

                 (e)  ACCREDITED INVESTOR:  The Investor is an 
accredited investor as defined in Regulation Section 230.501 promulgated 
under the Act.

                 (f)  RULE 144.  The Investor understands that the 
Shares and any Additional Shares must be held indefinitely unless such 
Shares or Additional Shares are subsequently registered under the Act or 
an exemption from registration is available.  The Investor has been 
advised or is aware of the provisions of Rule 144 promulgated under the 
Act.

                 (g)  LOCK-UP PERIOD.  Notwithstanding the foregoing, 
the Investor shall not sell (including a short sale), transfer or 
otherwise dispose of the Shares, or any Additional Shares issued to such 
Investor, at any time during the 105 day period following June 26, 1995.  
Notwithstanding the foregoing, during the remainder of the Valuation 
Period Investor will only transfer or otherwise dispose of its shares in 
accordance with the representations contained in Exhibit C.

                                   -11-
<PAGE>


                               ARTICLE III

                                Covenants
                                ---------

            Section 3.1  REGULATION S

                 (a)  Notwithstanding any of the foregoing, the Company 
acknowledges and agrees that in the event that a registration statement 
covering all of the Registrable Securities shall not have become 
effective within 105 days of the Closing Date, the legend described in 
Article V herein shall be removed on the 106th day following the 
Closing, in accordance with Article V herein, it being acknowledged by 
the Company that, in such event, the Investor shall be free to transfer, 
sell, pledge, or otherwise hypothecate the Shares and the Additional 
Shares issued pursuant to this Agreement in accordance with (i) 
Regulation S under the Act and (ii) the terms and conditions described 
in the letter attached hereto as Exhibit C.

                 (b)  The Company acknowledges and agrees that, in the 
event the Investor sells, transfers, pledges or otherwise hypothecates 
the Shares or Additional Shares in accordance with Section 3.1(a) 
herein, for purposes of clarifying and specifying the applicable 
Restricted Period under Regulation S, the Investor intends to observe as 
the Restricted Period (as defined in Regulation S) for the Shares being 
delivered at the Closing the period of 40 days commencing upon the 
Closing Date and ending 40 days thereafter, and to observe as the 
Restricted Period applicable to the Additional Shares, if any, the 
period of 40 days commencing upon the date upon which the same are 
delivered to the Investor hereunder.

                 Neither the Company nor any of its affiliates has 
engaged or will engage in any "directed selling efforts" (as such term 
is defined under Regulation S) with respect to the Shares or the 
Additional Shares, and the Company and its affiliates have complied and 
will comply with the "offering restrictions" requirements of Regulation 
S.

                 (c)  In the event the Investor sells, transfers or 
otherwise disposes of the Shares or the Additional Shares in accordance 
with Section 3.1(a) herein, the Investor covenants and agrees that such 
sale, transfer or other disposition will be made in compliance with the 
terms of Regulation S under the Act, as in effect at that time, 
including (i) that the Shares and the Additional Shares will not be 
offered or sold within the United States or to, or for the account or 
benefit of, any "U.S. person" (as such term is defined in Rule 902 (o) 
promulgated under the Act) except in accordance with the provisions of 
Rule 903 or Rule 904 of Regulation S under the  Act, pursuant to 
registration under the Act, or pursuant to an exemption from the 
registration requirements of the Act and (ii) that neither it, its 
affiliates, nor persons acting on their behalf, have engaged or will 
engage in "directed selling efforts" (as such term is defined by 
Regulation S) with respect to the Shares or the Additional Shares and 
that each of them has complied and will comply with the "offering 
restrictions" requirements of Regulation S.


            Section 3.2  SECURITIES COMPLIANCE.

                 (a)  The Company shall notify the SEC and the NASD, in 
accordance with their requirements, of the transactions contemplated by 
this Agreement, and shall take all other necessary action and 
proceedings as may be required and permitted by applicable law, rule and 

                                  -12-

<PAGE>

regulation, including, without limitation, the filing of a Form D with 
the SEC, for the legal and valid issuance of the Shares and the 
Additional Shares to the Investor.

                 (b)  The Investor understands that the Shares and, if 
any, the Additional Shares, are being offered and sold to it in reliance 
on a transactional exemption from the registration requirements of 
Federal and state securities laws and that the Company is relying upon 
the truth and accuracy of the representations, warranties, agreements, 
acknowledgments and understandings of such Investor set forth herein in 
order to determine the applicability of such exemptions and the 
suitability of such Investor to acquire the Shares and, if any, the 
Additional Shares.

            Section 3.3  CORPORATE.  (a) From the date hereof through 
the end of the Valuation Period the Company shall not (i) amend its 
Certificate or By-Laws so as to adversely affect any rights of the 
Investor; (ii) split, combine or reclassify its outstanding capital 
stock; (iii) declare or set aside or pay any dividend or other 
distribution with respect to the Company's outstanding Common Stock; 
(iv) issue or sell, directly or indirectly, shares of the Company's 
Common Stock in a manner or upon terms as could reasonably be expected 
to affect the market for the Common Stock materially and adversely; or 
(v) enter into any agreement with respect to the foregoing; and (vi) the 
Company shall at all times reserve and keep available, solely for 
issuance and delivery as Shares or Additional Shares hereunder, such 
shares of Common Stock as shall from time to time be issuable or 
reasonably be expected to be issuable as Shares or Additional Shares 
hereunder.

                 (b)  The Company will cause its Common Stock to 
continue to be registered under Sections 12(b) or 12(g) of the Exchange 
Act, will comply in all respects with its reporting and filing 
obligations under said act, will comply with all requirements related to 
any registration statement filed pursuant to Section 1.5 herein, and 
will not take any action or file any document (whether or not permitted 
by said Act or the rules thereunder) to terminate or suspend such 
registration or to terminate or suspend its reporting and filing 
obligations under said act, except as permitted herein.  The Company 
will take all action necessary to continue the listing or trading of its 
Common Stock on the Nasdaq National Market and will comply in all 
respects with the Company's reporting, filing and other obligations 
under the bylaws or rules of the NASD and Nasdaq.


                               ARTICLE IV

                               Conditions
                               ----------

            Section 4.1  CONDITIONS PRECEDENT TO THE OBLIGATION OF THE 
COMPANY TO SELL THE SHARES. The obligation hereunder of the Company to 
issue and/or sell the Shares or the Additional Shares to the Investor is 
further subject to the satisfaction, at or before the respective 
issuance and deliveries thereof, of each of the following conditions set 
forth below.  These conditions are for the Company's sole benefit and 
may be waived by the Company at any time in its sole discretion.

                 (a)  ACCURACY OF THE INVESTOR REPRESENTATIONS AND 
WARRANTIES.  The representations and warranties of the Investor shall be 
true and correct in all material respects as of the date when made and 
as of the date of such issuance and delivery as though made at that 
time.

                 (b)  PERFORMANCE BY THE INVESTOR.  The Investor shall 
have performed, satisfied and complied in all material respects with all 
covenants, agreements and conditions required by this Agreement to be 
performed, satisfied or complied with by the Investor at or prior to 
such date.

                                   -13-

<PAGE>

                 (c)  NO INJUNCTION.  No statute, rule, regulation, 
executive order, decree, ruling or injunction shall have been enacted, 
entered, promulgated or endorsed by any court or governmental authority 
of competent jurisdiction which  prohibits the consummation of any of 
the transactions contemplated by this Agreement.

            Section 4.2  CONDITIONS PRECEDENT TO THE OBLIGATION OF THE 
INVESTOR TO PURCHASE THE SHARES.  The obligation of the Investor 
hereunder to acquire and pay for the Shares is subject to the 
satisfaction, at or before the Closing of each of the following 
conditions set forth below.  These conditions are for the Investor's 
sole benefit and may be waived by the Investor at any time in its sole 
discretion.

                 (a)  ACCURACY OF THE COMPANY'S REPRESENTATIONS AND 
WARRANTIES.  The representations and warranties of the Company shall be 
true and correct in all material respects as of the date when made and 
as of the Closing Date as though made at that time (except for 
representations and warranties that speak as of a particular date).

                 (b)  PERFORMANCE BY THE COMPANY.  The Company shall 
have performed, satisfied and complied in all material respects with all 
covenants, agreements and conditions required by this Agreement to be 
performed, satisfied or complied with by the Company at or prior to the 
Closing.

                 (c)  NASDAQ.  From the date hereof to the Closing Date, 
as to the Shares to be issued and delivered on the Closing Date, trading 
in the Company's Common Stock shall not have been suspended by the SEC 
or the Nasdaq National Market (except for any suspension of trading of 
limited duration agreed to between the Company and the Nasdaq National 
Market solely to permit dissemination of material information regarding 
the Company), and trading in securities generally as reported by Nasdaq 
shall not have been suspended or limited or minimum prices shall not 
have been established on securities whose trades are reported by Nasdaq.  
Notwithstanding the foregoing sentence, in the event that at any point 
on or prior to the first day of the Valuation Period, trading in the 
Common Stock is suspended by the SEC or the Nasdaq National Market, (i) 
calculation of the Average Stock Price shall be suspended for such 
period of time as trading in the Common Stock is suspended and (ii) the 
Valuation Period shall be reset so that such Valuation Period shall 
begin on the 115th calendar day following June 26, 1995 and shall end on 
the 45th calendar day thereafter for which quotations for the Company's 
Common Stock on the Nasdaq National Market have been available for a 
total of 45 calendar days.  In the event that the Company's Common Stock 
is delisted from the Nasdaq National Market at any time during the 
Valuation Period or in the event that trading in the Common Stock is 
suspended for a period of more than thirty (30) days subsequent to the 
commencement of the Valuation Period, (iii) the Valuation Period will be 
deemed to have concluded on the date on which the Common Stock was 
delisted or such trading was suspended, (iv) the Average Stock Price 
shall be calculated based on the number of days in such shortened 
Valuation Period, and (v) the Investor shall receive any Additional 
Shares owed to it pursuant to Section 1.3(c) herein within five (5) 
business days of the conclusion of the shortened Valuation Period.  In 
no event shall the Investor be required to deliver any shares for 
cancellation pursuant to Section 1.3(d) herein if the Common Stock is 
delisted from the Nasdaq National Market or if trading in the Common 
Stock is suspended for more than thirty (30) days during the Valuation 
Period or prior to the effectiveness of the Company's Initial 
Registration.

                 (d)  NO INJUNCTION.  No statute, rule, regulation, 
executive order, decree, ruling or injunction shall have been enacted, 
entered, promulgated or endorsed by any court or 

                                 -14-

<PAGE>

governmental authority of competent jurisdiction which prohibits the 
consummation of any of the transactions contemplated by this Agreement.

                 (e)  OPINION OF COUNSEL, ETC.  At the Closing the 
Investor shall have received an opinion of Brobeck Phleger & Harrison, 
counsel to the Company, in form and substance satisfactory to the 
Investor and its counsel (in substantially the form of Exhibit B 
hereto), and such other certificates and documents as the Investor or 
its counsel shall reasonably require incident to the Closing.


                                ARTICLE V

                             Legend on Stock
                             ---------------

            Each certificate representing the Shares issued pursuant to 
Section 1.3 shall be stamped or otherwise imprinted with a legend 
substantially in the following form:

            THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE 
            SECURITIES ACT OF 1933 OR ANY STATE SECURITIES LAWS.  
            THEY MAY NOT BE SOLD OR OFFERED FOR SALE IN THE 
            ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO 
            THE SECURITIES UNDER SAID ACT AND ANY APPLICABLE 
            STATE SECURITIES LAW OR AN APPLICABLE EXEMPTION FROM 
            THE REGISTRATION REQUIREMENTS OF THE ACT.  THIS 
            LEGEND SHALL CEASE TO HAVE ANY FORCE OR EFFECT AND 
            WILL BE REMOVED ON OCTOBER 7, 1995 UNLESS AN OPINION 
            OF COUNSEL TO THE COMPANY, IN FORM AND SUBSTANCE 
            SATISFACTORY TO THE INVESTOR AND ITS COUNSEL, IS 
            DELIVERED TO THE COMPANY'S TRANSFER AGENT ON OR 
            PRIOR TO SUCH DATE STATING THAT REMOVAL OF THIS 
            LEGEND IS NOT PERMITTED UNDER LAW DUE TO A CHANGE IN 
            LAW SUBSEQUENT TO JUNE 23, 1995.


            Not withstanding the foregoing, this legend shall cease to 
have any force or effect and will be removed on October 7, 1995, unless 
an opinion on counsel to the Company in form and substance satisfactory 
to the Investor and its counsel, is delivered to the Company's transfer 
agent, on or prior to such date stating that removal of this legend is 
not permitted under law due to a change in law subsequent to the date 
hereof.

            No certificate representing Additional Shares, if any, 
required to be issued pursuant to this Agreement will bear a restrictive 
legend unless an opinion of the Company's counsel, in form and substance 
satisfactory to the Investor, has been issued to the Company's transfer 
agent on or prior to the issuance of such Additional Shares stating that 
such a legend is required by law due to a change in law subsequent to 
the date hereof.

                                  -15-

<PAGE>

                               ARTICLE VI

                              Termination
                              -----------

            Section 6.1  TERMINATION BY MUTUAL CONSENT.  This Agreement 
may be terminated at any time prior to the Closing by the mutual consent 
of the Company and the Investor, by action of their respective Boards of 
Directors or other governing body.

            Section 6.2  OTHER TERMINATION.  This Agreement may be 
terminated by action of the Board of Directors or other governing body 
of the Investor or the Company at any time after July 7, 1995 if the 
Closing shall not have been consummated by July 7, 1995.

            Section 6.3  AUTOMATIC TERMINATION.  This Agreement shall 
automatically terminate without any further action of either party 
hereto if the Closing shall not have occurred by July 7, 1995.


                               ARTICLE VII

                              Miscellaneous
                              -------------

            Section 7.1  FEES AND EXPENSES.  Each party shall pay the 
fees and expenses of its advisers, counsel, accountants and other 
experts, if any, and all other expenses incurred by such party incident 
to the negotiation, preparation, execution, delivery and performance of 
this Agreement, provided that the Company shall pay, at the Closing, all 
attorneys' fees and expenses incurred by the Investor and Cappello 
Capital Corp., up to a maximum of $5,000, in connection with the 
preparation, negotiation, execution and delivery of this Agreement and 
the transactions contemplated hereunder.  Without limiting the 
generality of the foregoing, The Kriegsman Group shall be entitled to a 
finders fee pursuant to a separate agreement with respect thereto 
between such finder and the Company, and the Company shall be solely 
responsible for the full payment thereof and shall indemnify and hold 
harmless the Investor from and against all loss, cost, damage or expense 
arising therefrom.  The Company shall pay all stamp and other taxes and 
duties levied in connection with the issuance of the Shares or the 
Additional Shares pursuant hereto.

            Section 7.2  SPECIFIC ENFORCEMENT; CONSENT TO JURISDICTION.

                 (a)  The Company and the Investor acknowledge and agree 
that irreparable damage would occur in the event that any of the 
provisions of this Agreement were not performed in accordance with their 
specific terms or were otherwise breached.  It is accordingly agreed 
that the parties shall be entitled to an injunction or injunctions to 
prevent or cure breaches of the provisions of this Agreement and to 
enforce specifically the terms and provisions hereof, this being in 
addition to any other remedy to which either of them may be entitled by 
law or equity.

                 (b)  Each of the Company and the Investor (i) hereby 
irrevocably submits to the exclusive jurisdiction of the United States 
District Court and other courts of the United States sitting in 
California for the purposes of any suit, action or proceeding arising 
out of or relating to this  Agreement and (ii) hereby waives, and agrees 
not to assert in any such suit, action or proceeding, any claim that it 
is not personally subject to the jurisdiction of such court, that the 
suit, action or proceeding is brought in an inconvenient forum or that 
the venue of the suit, action or proceeding is improper.  Each of the 
Company and the Investor consents to process being served in any such 
suit, action or proceeding by mailing a copy thereof to such party at 
the address in effect for notices to it under this Agreement and 

                                 -16-

<PAGE>

agrees that such service shall constitute good and sufficient service of 
process and notice thereof.  Nothing in this paragraph shall affect or 
limit any right to serve process in any other manner permitted by law.

            Section 7.3  ENTIRE AGREEMENT; AMENDMENTS.  This Agreement 
contains the entire understanding of the parties with respect to the 
matters covered hereby and thereby and, except as specifically set forth 
herein, neither the Company nor the Investor makes any representation, 
warranty, covenant or undertaking with respect to such matters.  No 
provision of this Agreement may be waived or amended other than by a 
written instrument signed by the party against whom enforcement of any 
such amendment or waiver is sought.

            Section 7.4  NOTICES.  Any notice or other communication 
required or permitted to be given hereunder shall be in writing and 
shall be effective (a) upon hand delivery or delivery by telex (with 
correct answer back received), telecopy or facsimile at the address or 
number designated below (if delivered on a business day during normal 
business hours where such notice is to be received), or the first 
business day following such delivery (if delivered other than on a 
business day during normal business hours where such notice is to be 
received) or (b) on the second business day following the date of 
mailing by express courier service, fully prepaid, addressed to such 
address, or upon actual receipt of such mailing, whichever shall first 
occur.  The addresses for such communications shall be:

            to the Company:

                           Advanced Tissue Sciences, Inc.
                           10933 North Torrey Pines Road
                           La Jolla, California 92037
                           Attn:  Chief Executive Officer

            with copies to:

                           Brobeck Phleger & Harrison
                           4675 MacArthur Court
                           Suite 1000
                           Newport Beach, California 92660
                           Attn:  Laura M. Brower, Esq.

            to the Investor:

                           Kyneton Investments Ltd.
                           c/o Slofam Managed Investments
                           51 Wessel Road
                           Rivonia 2128
                           South Africa

            with copies to:

                           Cappello Capital Corp.
                           1299 Ocean Avenue, Suite 306
                           Santa Monica, California 90401
                           Attn:  Gerard K. Cappello
                              
                                  -17-
<PAGE>


                           O'Melveny & Myers
                           610 Newport Center Drive, Suite 1700
                           Newport Beach, California 92660
                           Attn:	Barton Beek, Esq.



Either party hereto may from time to time change its address for notices 
under this Section 7.4 by giving at least 10 days' written notice of 
such changed address to the other party hereto.

            Section 7.5  WAIVERS.  No waiver by either party of any 
default with respect to any provision, condition or requirement of this 
Agreement shall be deemed to be a continuing waiver in the future or a 
waiver of any other provision, condition or requirement hereof, nor 
shall any delay or omission of either party to exercise any right 
hereunder in any manner impair the exercise of any such right accruing 
to it thereafter.

            Section 7.6  HEADINGS.  The headings herein are for 
convenience only, do not constitute a part of this Agreement  and shall 
not be deemed to limit or affect any of the provisions hereof.

            Section 7.7  SUCCESSORS AND ASSIGNS.  This Agreement shall 
be binding upon and inure to the benefit of the parties and their 
successors and assigns.  The parties hereto may amend this Agreement 
without notice to or the consent of any third party.  Neither the 
Company nor the Investor shall assign this Agreement or any rights or 
obligations hereunder without the prior written consent of the other 
(which consent may be withheld for any reason in the sole discretion of 
the party from whom consent is sought); provided, however, that the 
Company may assign its rights and obligations hereunder to any acquirer 
of substantially all of the assets or a controlling equity interest of 
the Company.  The assignment by a party of this Agreement or any rights 
hereunder shall not affect the obligations of such party under this 
Agreement.

            Section 7.8  NO THIRD PARTY BENEFICIARIES.  This Agreement 
is intended for the benefit of the parties hereto and their respective 
permitted successors and assigns and is not for the benefit of, nor may 
any provision hereof be enforced by, any other person.

            Section 7.9  GOVERNING LAW.  This Agreement shall be 
governed by and construed and enforced in accordance with the internal 
laws of California without regard to the principles of conflict of laws.

            Section 7.10  SURVIVAL. The representations and warranties 
of the Company and the Investor contained in Article II and the 
agreements and covenants set forth in Articles I and III shall survive 
the Closing.

            Section 7.11  EXECUTION.  This Agreement may be executed in 
two or more counterparts, all of which shall be considered one and the 
same agreement and shall become effective when counterparts have been 
signed by each party and delivered to the other party, it being 
understood that both parties need not sign the same counterpart.  In the 
event any signature is delivered by facsimile transmission, the party 
using such means of delivery shall cause four additional executed 
signature pages to be physically delivered to the other party within 
five days of the execution and delivery hereof.

                                  -18-

<PAGE>

            Section 7.12  PUBLICITY.  The Company and the Investor shall 
consult and cooperate with each other in issuing any press releases or 
otherwise making public statements with respect to the transactions 
contemplated hereby, provided the foregoing shall not interfere with the 
legal obligations of either party with respect to public disclosure; and 
provided further, that neither the Company nor the Investor shall be 
required to consult with the other if any such press release or public 
statement does not specifically name the other.


              [Remainder of page intentionally left blank.]

                                 -19-

<PAGE>

            IN WITNESS WHEREOF, the parties hereto have caused this 
Agreement to be duly executed by their respective authorized officers as 
of the date hereof.

                               ADVANCED TISSUE SCIENCES, INC.


                               By:  /s/  Arthur J. Benvenuto
                                    -----------------------------
                                    Name:  Arthur J. Benvenuto
                                    Its:  Chairman, President and
                                           Chief Executive Officer


                               KYNETON INVESTMENTS LTD.

                               By:  /s/  Ansel A. Slome
                                    --------------------------------
                                    Name:  Ansel A. Slome
                                    Its:  Duly Authorized Agent


                                 -20-

<PAGE>

                                                         EXHIBIT A

                          CAPITALIZATION SUMMARY


The following table reconciles the Company's outstanding Common Stock 
and options and warrants as reported in the Company's Quarterly Report 
on Form 10-Q as of March 31, 1995 to June 13, 1995.

                                            Common        Options and
                                             Stock         Warrants
                                          Outstanding     Outstanding
                                          -----------     -----------

   Outstanding per Form 10-Q              30,570,993       4,186,957
   Options and warrants exercised            561,200        (561,200)
   Options and warrants granted                    -         125,000
   Options and warrants canceled                   -        (139,209)
                                          ----------       ---------

   Outstanding as of June 13, 1995        31,132,193       3,611,548
                                          ==========       =========


As of June 13, 1995, the Company had 1,900,462 remaining available for 
grant under its 1992 Stock Option/Stock Issuance Plan.  Additional 
shares previously granted under the Plan have been exercised subsequent 
to June 13, 1995.

The Company issued 1,500,000 shares of Common Stock (subject to 
adjustment) on June 26, 1995 (the "Private Placement").  In connection 
with the Private Placement, the Company  issued warrants to purchase 
135,000 shares of Common Stock (subject to adjustment) to certain 
investment advisors on June 26, 1995 at an initial exercise price of 
$6.86 per share.  In addition, the Company will issue warrants to 
purchase 65,598 shares of Common Stock (subject to adjustment) to 
certain investment advisors involved in this transaction on the Closing 
Date at an initial exercise price of $6.86 per share.

On January 5, 1995, the Company's Board of Directors (the "Board") 
adopted a Shareholder Rights Plan (the "Rights Plan").  Pursuant to the 
Rights Plan, the Board declared a dividend of one preferred share 
purchase right (the "Right") for each share of Common Stock outstanding 
on January 20, 1995.  Each Right entitles the registered holder to 
purchase from the Company one-hundredth of a share of Series A Junior 
Participating Preferred Stock at an exercise price of $55 per one-
hundredth share, subject to adjustment.



<PAGE>


                                                       EXHIBIT C

                                          July 5, 1995
Advanced Tissue Sciences, Inc.
10933 North Torrey Pines Road
La Jolla, California 92037
Attention:  Arthur Benvenuto

Re:	Regulation S Offering
    ---------------------

Ladies and Gentlemen:

Reference is made to the Investment Agreement of even date and delivery 
herewith (the "Agreement") between the undersigned ("Investor") and 
Advanced Tissue Sciences, Inc.  Capitalized terms contained in this 
letter shall have the same meaning ascribed to them in the Agreement.

In addition to the representations and covenants of the Investor 
contained in the Agreement, Investor further covenants and agrees as 
follows:

          1.     In the event the Investor engages in short sales 
          transactions or other hedging activities during the period from 
          105 days following June 26, 1995 through 160 days following June 
          26, 1995 which involve, among other things, sales of Common Stock 
          of the Company, Investor will, to the extent within its reasonable 
          control, conduct such activities so as not to complete or effect 
          any such sale on any trading day during such period at a price 
          which is lower than the lowest sale effected on such day by 
          persons other than the Investor;

          2.     Investor covenants that it will comply with all applicable 
          laws, rules and regulations regarding the foregoing activities 
          and/or the financing of the Shares and Additional Shares 
          including, if applicable, compliance with Regulation S.


                                      Very truly yours,


                                      KYNETON INVESTMENTS LTD.


                                      By:  /s/  Ansel A. Slome
                                           ---------------------------
                                           Name:  Ansel A. Slome
                                           Its:  Duly Authorized Agent




<PAGE>
                                                              EXHIBIT 4.2

                             INVESTMENT AGREEMENT


                                   Between


                        ADVANCED TISSUE SCIENCES, INC.


                                      And

                          ARBCO ASSOCIATES, L.P. AND
                        OFFENSE GROUP ASSOCIATES, L.P.




                          Dated as of July 11, 1995







         		THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN 
           REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE 
           "ACT"), AND MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, 
           HYPOTHECATED OR OTHERWISE TRANSFERRED UNLESS THERE IS AN 
           EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT COVERING 
           SUCH SECURITIES OR THE COMPANY RECEIVES AN OPINION OF 
           COUNSEL REASONABLY ACCEPTABLE TO THE COMPANY STATING THAT 
           SUCH SALE OR TRANSFER IS EXEMPT FROM THE REGISTRATION AND 
           PROSPECTUS DELIVERY REQUIREMENTS OF SUCH ACT.

<PAGE>
	

            INVESTMENT AGREEMENT dated as of July 11, 1995 between Advanced 
Tissue Sciences, Inc., a corporation organized and existing under the laws of 
the State of Delaware (the "Company") and the entities identified on Schedule 
I hereto (individually, an "Investor" and collectively, the "Investors").

            WHEREAS, the parties desire that the Investors become equity 
investors in the Company by purchasing an aggregate of 385,569 shares of the 
Company's Common Stock, par value $.01 per share (the "Common Stock").

            NOW, THEREFORE, the parties hereto agree as follows:


                                   ARTICLE I


                        Purchase and Sale of Common Stock
                        ---------------------------------

            Section 1.1  PURCHASE AND SALE OF COMMON STOCK.  Upon the terms 
and conditions set forth herein, the Company shall issue and sell to the 
Investors, and the Investors shall purchase from the Company, 385,569 shares 
of the Company's Common Stock (the "Shares") in the amounts indicated on 
Schedule I hereto.

            Section 1.2  PURCHASE PRICE.  The aggregate purchase price for the 
Shares (the "Purchase Price") shall equal $2,645,000 payable in cash by wire 
transfer or cashier's check in immediately available funds.

            Section 1.3  SHARE NUMBER; VALUATION PERIOD.

                 (a)  The number of Shares that the Company shall be obligated 
to issue and sell and the Investors shall be obligated to purchase hereunder, 
in the aggregate, is referred to herein as the "Share Number."  Subject to 
adjustment as provided in Sections 1.3(c) and 1.3(e), the Share Number shall 
initially be 385,569.

                 (b)  The "Valuation Period" shall be a 45 calendar day period 
commencing on and including the first business day which is 160 calendar days 
after June 26, 1995 as the same may be modified pursuant to Section 4.2(c) 
hereof.

                 (c)  Notwithstanding Section 1.3(a) above, and except as 
hereinafter provided, if the Average Share Price (hereinafter defined) during 
the Valuation Period is less than $7.75, then the Company shall deliver to the 
Investors, at no additional cost to the Investors, in proportion to their 
relative investment, and in addition to the initial Share Number, the number 
of shares of Common Stock that is obtained by subtracting (x) 385,569 from (y) 
the quotient obtained by dividing the Purchase Price by 88.5% of the Average 
Share Price (rounded to the nearest whole number) (together with any 
additional shares issued pursuant to Section 1.3(e) herein, the "Additional 
Shares").

                 (d)  Notwithstanding Section 1.3(a) above, and except as 
hereinafter provided, if the Average Share Price during the Valuation Period 
is greater than $7.75, the Investors shall pay 

<PAGE>

to the Company, in proportion to their relative investment, the dollar amount 
by which (x) the product of 88.5% of the Average Share Price and the Share 
Number exceeds (y) the product of $6.86 and the Share Number.

                 (e)  Notwithstanding Section 1.3(c) above, in the event that 
the Company, on or prior to 205 days from June 26, 1995, issues or sells any 
shares of its Common Stock or any of its securities which are convertible into 
or exchangeable for its Common Stock or any warrants or other rights to 
subscribe for or to purchase or any options for the purchase of, its Common 
Stock (other than shares or options issued pursuant to the Company's option 
plans or shares issued upon exercise of options, warrants or rights 
outstanding on the Closing Date or as provided on Exhibit A hereto), at an 
initial purchase price which is less than $6.86 per share (the "Subsequent 
Sale Price"), then the Company shall deliver to the Investors, at no 
additional cost to the Investors, in proportion to their relative investment, 
and in addition to the Share Number, the number of shares of Common Stock that 
is obtained by subtracting (x) 385,569 from (y) the quotient obtained by 
dividing the Purchase Price by the Subsequent Sale Price (rounded to the 
nearest whole number).

                 (f)  Notwithstanding any of the foregoing, in the event both 
subsections 1.3(c) and 1.3(e) are applicable, the number of Additional Shares 
issuable hereunder shall be the greater of the number of Additional Shares 
issuable pursuant to Section 1.3(c) herein and the number of Additional Shares 
issuable pursuant to Section 1.3(e) herein.

                 (g)  For purposes hereof, the Average Share Price shall mean 
the average of the closing trading prices of the Company's Common Stock on the 
Nasdaq National Market, as reported by the Nasdaq National Market for each 
trading day during the Valuation Period.

            Section 1.4  THE CLOSING.

                 (a)  The closing of the purchase and sale of the Shares (the 
"Closing"), shall take place (a) at the offices of the Investors, at 10:00 
a.m., local time on the later of the following:  (i) July 12, 1995, and (ii) 
the date on which the last to be fulfilled or waived of the conditions set 
forth in Article IV hereof and applicable to the Closing shall be fulfilled or 
waived in accordance herewith, or (b) at such other time and place and/or on 
such other date as the Investors and the Company may agree.  The date on which 
the Closing occurs is referred to herein as the "Closing Date."

                 (b)  (i)  On the Closing Date, the Company shall deliver to 
the Investors certificates representing the Share Number to be issued and sold 
to the Investors on such date and registered in the name of the Investors or 
deposit such Share Number into the accounts designated by the Investors and 
(ii) on the Closing Date, the Investors shall deliver to the Company the 
Purchase Price by cashier's check or wire transfer in immediately available 
funds to such account as shall be designated in writing by the Company.  In 
addition, each of the Company and the Investors shall deliver all documents, 
instruments and writings required to be delivered by either of them pursuant 
to this Agreement at or prior to the Closing.

            Section 1.5  COVENANT TO REGISTER.  For purposes of this Section 
1.5, the following definitions shall apply:


                                 -2-
<PAGE>
                 (a)  (i)  The terms "register," "registered," and 
"registration" refer to a registration under the Securities Act of 1933, as 
amended (the "Act") effected by preparing and filing a registration statement 
or similar document in compliance with the Act, and the declaration or 
ordering of effectiveness of such registration statement, document or 
amendment thereto.

                     (ii)  The term "Registrable Securities" means the Shares 
and any Additional Shares issued pursuant to Section 1.3 hereof and any 
securities of the Company or securities of any successor corporation issued 
as, or issuable upon the conversion or exercise of any warrant, right or other 
security that is issued as a dividend or other distribution with respect to, 
or in exchange for, or in replacement of, the Shares and any Additional Shares 
issued pursuant to Section 1.3 hereof.

                 (b)  (i)  The Company shall, as expeditiously as possible 
following the Closing, file a registration statement on Form S-3 or an 
equivalent thereof with the Securities and Exchange Commission (the "SEC") 
promptly after the Closing Date, covering all the Registrable Securities, and 
shall use its best efforts to cause such registration statement to become 
effective within 160 days of June 26, 1995 (the "Initial Registration").  In 
the event such registration is not so declared effective, the holder of the 
Registrable Securities shall have the right to require by notice in writing 
that the Company register all or any part of the Registrable Securities held 
by such holder (a "Demand Registration") and the Company shall thereupon 
effect such registration in accordance herewith.  The parties agree that if 
the holder of Registrable Securities demands registration of less than all of 
the Registrable Securities, the Company, at its option, may nevertheless file 
a registration statement covering all of the Registrable Securities.  If such 
registration statement is declared effective with respect to all Registrable 
Securities the demand registration rights granted pursuant to this Section 1.5 
(b) (i) shall cease.  If such registration statement is not declared effective 
with respect to all Registrable Securities the demand registration rights 
described herein shall remain in effect until all Registrable Securities have 
been registered under the Act.

                     (ii)  The Company shall not be obligated to effect the 
Demand Registration (i) if all of the Registrable Securities held by the 
holder of Registrable Securities which are intended to be covered by the 
Demand Registration are, at the time of the request of a Demand Registration, 
included in an effective registration statement and the Company is in 
compliance with its obligations under Subsection (d) (ii) through (v) hereof.

                     (iii)  The Company may suspend the effectiveness of any 
such registration effected pursuant to this Section 1.5(b) in the event, and 
for such period of time as, such a suspension is required by the rules and 
regulations of the SEC.

                     (iv)  If the registration statement covering the 
Registrable Securities is not effective within 160 days of June 26, 1995, then 
the adjustments required by Sections 1.3(c) or (d) or Section 1.6 shall be 
calculated using 77.0% of the Average Share Price.

                 (c)  If the Company proposes to register (including for this 
purpose a registration effected by the Company for shareholders other than the 
Investors) any of its stock or other securities under the Act in connection 
with a public offering of such securities (other than a registration on Form 
S-4, Form S-8 or other limited purpose form) and the Registrable Securities 
have not heretofore been included in a registration statement under Subsection 
(b), which remains effective, the Company shall, at such time, promptly give 
the holder of Registrable Securities written 

                                  -3-
<PAGE>
notice of such registration.  Upon the written request of the holder of 
Registrable Securities given within twenty (20) days after receipt of such 
notice by the holder of Registrable Securities, the Company shall use its 
best efforts to cause to be registered under the Act all Registrable 
Securities that the holder of Registrable Securities requests to be 
registered.  However, the Company shall have no obligation under this 
Subsection (c) to the extent that, with respect to a public offering 
registration, any underwriter of such public offering reasonably requests 
that the Registrable Securities or a portion thereof be excluded therefrom.

                 (d)  Whenever required under this Section 1.5 to effect the 
registration of any Registrable Securities, including, without limitation, the 
Initial Registration, the Company shall, as expeditiously as reasonably 
possible:

                     (i)  Prepare and file with the SEC a registration 
statement with respect to such Registrable Securities and use its best efforts 
to cause such registration to become effective and, upon the request of the 
Investors, keep such registration statement effective, pursuant to the 
provisions of Regulation Section 230.415 or otherwise, for so long as the 
holders of Registrable Securities desires to dispose of the securities 
covered by such registration statement (but not after the holders of 
Registrable Securities, in the reasonable opinion of its counsel, is free 
to sell all of such securities in any three month period under the 
provisions of Rule 144 under the Act).

                     (ii)  Prepare and file with the SEC such amendments and 
supplements to such registration statement and the prospectus used in 
connection with such registration statement as may be necessary to comply with 
the provisions of the Act with respect to the disposition of all securities 
covered by such registration statement.

                     (iii)  Furnish to the holders of Registrable Securities 
such numbers of copies of a prospectus, including a preliminary prospectus, in 
conformity with the requirements of the Act, and such other documents as the 
holders of Registrable Securities may reasonably require in order to 
facilitate the disposition of Registrable Securities owned by the holders of 
Registrable Securities.

                     (iv)  Use its best efforts to register and qualify the 
securities covered by such registration statement under such other securities 
or "Blue Sky" laws of such jurisdictions as shall be reasonably requested by 
the holders of Registrable Securities, provided that the Company shall not be 
required in connection therewith or as a condition thereto to qualify to do 
business or to file a general consent to service and process in any such 
states or jurisdictions.

                     (v)  Notify the holders of Registrable Securities of the 
happening of any event as a result of which the prospectus included in such 
registration statement, as then in effect, includes an untrue statement of 
material fact or omits to state a material fact required to be stated therein 
or necessary to make the statements therein not misleading in light of the 
circumstances then existing.

                     (vi)  Furnish, at the request of the holders of 
Registrable Securities, an opinion of counsel of the Company, dated the 
effective date of the registration statement, as to the due authorization and 
issuance of the securities being registered and compliance with securities 
laws by the Company in connection with the authorization and issuance thereof.

                                  -4-

<PAGE>

                     (vii)  Use its best efforts to list the Registrable 
Securities covered by such registration statement with any securities exchange 
on which the Common Stock is then listed;

                    (viii)  Make available for inspection by the holders of 
Registrable Securities, upon request, all SEC Documents filed subsequent to 
the Closing and require the Company's officers, directors and employees to 
supply all information reasonably requested by any holder of Registrable 
Securities in connection with such registration statement.

                 (e)  The holders of Registrable Securities will furnish to 
the Company in connection with any registration under this Section 1.5 such 
information regarding itself, the Registrable Securities and other securities 
of the Company held by it, and the intended method of disposition of such 
securities as shall be required to effect the registration of the Registrable 
Securities held by the holders of Registrable Securities.

                 (f)  (i)  The Company shall indemnify, defend and hold 
harmless each holder of Registrable Securities which are included in a 
registration statement pursuant to the provisions of subsections (b) or (c) 
from and against, and shall reimburse such holder with respect to, any and all 
claims, suits, demands, causes of action, losses, damages, liabilities, costs 
or expenses ("Liabilities") to which such holder may become subject under the 
Act or otherwise, arising from or relating to (A) any untrue statement or 
alleged untrue statement of any material fact contained in such registration 
statement, any prospectus contained therein or any amendment or supplement 
thereto, or (B) the omission or alleged omission to state therein a material 
fact required to be stated therein or necessary to make the statements 
therein, in light of the circumstances in which they were made, not 
misleading; PROVIDED, HOWEVER, that the Company shall not be liable in any 
such case to the extent that any such Liability arises out of or is based upon 
an untrue statement or alleged untrue statement or omission or alleged 
omission so made in conformity with information furnished by such holders in 
writing specifically for use in the preparation thereof.

                     (ii)  Promptly after receipt by the holders of 
Registrable Securities of notice of the commencement of any action, the 
holders of Registrable Securities shall, if a claim in respect thereof is to 
be made against the Company hereunder, notify the Company in writing thereof, 
but the omission so to notify the Company shall not relieve the Company from 
any Liability which it may have to the holders of Registrable Securities other 
than under this section and shall only relieve it from any Liability which it 
may have to the holders of Registrable Securities under this section if and to 
the extent the Company is prejudiced by such omission.  In case any such 
action shall be brought against the holders of Registrable Securities and the 
holders of Registrable Securities shall notify the Company of the commencement 
thereof, the Company shall be entitled to participate in and, to the extent it 
shall wish, to assume and undertake the defense thereof with counsel 
reasonably satisfactory to the holders of Registrable Securities, and, after 
notice from the Company to the holders of Registrable Securities of its 
election so to assume and undertake the defense thereof, the Company shall not 
be liable to the holders of Registrable Securities under this section for any 
legal expenses subsequently incurred by the holders of Registrable Securities 
in connection with the defense thereof other than reasonable costs of 
investigation and of liaison with counsel so selected, PROVIDED, HOWEVER, that 
if the defendants in any such action include both the Company and the holders 
of Registrable Securities and the holders of Registrable Securities shall have 
reasonably concluded that there may be reasonable defenses available to it 
which are different from or additional to those available to the Company or if 
the interests of the holders of Registrable Securities reasonably may be 
deemed to conflict with the interests of the Company, the holders of 
Registrable Securities shall have 

                                 -5-

<PAGE>

the right to select a separate counsel and to assume such legal defenses and 
otherwise to participate in the defense of such action, with the expenses 
and fees of such separate counsel and other expenses related to such 
participation to be reimbursed by the Company as incurred.

                 (g)  (i)  Except as provided in subparagraph (ii) below, with 
respect to the inclusion of Registrable Securities in a registration statement 
pursuant to subsections (b) or (c), all fees, costs and expenses of and 
incidental to such registration, inclusion and public offering shall be borne 
by the Company; provided, however, that any securityholders participating in 
such registration shall bear their pro rata share of the underwriting 
discounts and commissions, if any, incurred in connection with such 
registration.

                     (ii)  The fees, costs and expenses of registration to be 
borne by the Company as provided in this Subsection (g) shall include, without 
limitation, all registration, filing and NASD fees, printing expenses, fees 
and disbursements of counsel and accountants for the Company, and all legal 
fees and disbursements and other expenses of complying with state securities 
or Blue Sky laws of any jurisdiction or jurisdictions in which securities to 
be offered are to be registered and qualified.  Fees and disbursements of 
counsel and accountants for the selling securityholders shall, however, be 
borne by the respective selling securityholder.

                 (h)  (i)  The rights to cause the Company to register all or 
any portion of Registrable Securities pursuant to this Section 1.5 may be 
assigned by the Investors to a transferee or assignee of 20% or more, in the 
aggregate, of the Shares and the Additional Shares.  Within a reasonable time 
after such transfer the Investors shall notify the Company of the name and 
address of such transferee or assignee and the securities with respect to 
which such registration rights are being assigned.  Such assignment shall be 
effective only if immediately following such transfer the further disposition 
of such securities by the transferee or assignee is restricted under the Act.  
Any transferee shall agree in writing at the time of transfer to be bound by 
the provisions of this Section 1.5.

                     (ii)  From and after the date of this Agreement, the 
Company shall not agree to allow the holders of any securities of the Company 
to include any of their securities in any registration statement filed by the 
Company pursuant to subsection (b) unless the inclusion of such securities 
will not reduce the amount of the Registrable Securities included therein.

            Section 1.6  ADJUSTMENTS.  If the Investors shall be entitled to 
the issuance of Additional Shares, the Company shall deliver to the Investors 
at the offices of the Investors on the third (3rd) business day after the end 
of the Valuation Period one or more certificates representing the Additional 
Shares so to be delivered in accordance with this Agreement, registered in the 
name of the Investors, or deposit such Additional Shares into accounts 
designated by the Investors; provided, however, that if the sum of the shares 
then beneficially owned by the Investors, and any Additional Shares then 
issuable to the Investors, as determined by the Investors, in their sole 
determination, shall equal 5.0% or more of the shares of Company's Common 
Stock issued and outstanding (as determined in accordance with Section 13(d) 
of the Securities Exchange Act of 1934) just prior to the Closing, then, and 
in such event, (x) the number of Additional Shares to be issued to the 
Investors pursuant to this paragraph shall be reduced to the number which, 
together with the Share Number, shall equal 4.99% of the shares of the 
Company's Common Stock issued and outstanding (as so determined) just prior to 
the Closing, and (y) in consideration for such reduction in Additional Shares, 
the Company shall pay to the Investors a sum equal to the greater of (a) the 
product of 88.5% of the Average Share Price and the reduction in the 
Additional Shares to be issued as a result of the 

                                 -6-

<PAGE>

preceding clause (x), and (b) the product of the Subsequent Sale Price and the 
reduction in the Additional Shares to be issued as a result of the preceding 
clause (x).  Similarly, if the Company shall be entitled to additional funds 
pursuant to Section 1.3(d), the Investors shall deliver to the Company at 
its offices on the third (3rd) business day after the end of the Valuation 
Period, such proceeds (in proportion to their relative investment) in cash 
by wire transfer or cashier's check in immediately available funds.

Section 1.7  RESCHEDULING.  If after the date hereof and prior to the 
expiration of the Valuation Period any person shall (a) publicly announce a 
tender offer or exchange offer for the Company's Common Stock, or (b) publicly 
announce plans for a merger, consolidation or potential change in control of 
the Company, the Investors, together but not individually, may in their sole 
discretion elect by written notice to the Company to shorten the Valuation 
Period so as to end on a date which is either before or after the consummation 
of the record date for the consummation of any such transaction, which 
election must be made prior to consummation of any such transaction.  For 
purposes of the foregoing, it is understood and agreed that the Investors may, 
but shall not be required to, reduce or entirely eliminate the Valuation 
Period or to reschedule the Valuation Period.


                                   ARTICLE II

                          Representations and Warranties
                          ------------------------------

            Section 2.1  REPRESENTATIONS AND WARRANTIES OF THE COMPANY.  The 
Company hereby makes the following representations and warranties to the 
Investors:

                 (a)  ORGANIZATION AND QUALIFICATION.  The Company is a 
corporation duly incorporated and existing in good standing under the laws of 
the State of Delaware, and has the requisite corporate power to own its 
properties and to carry on its business as now being conducted.  The Company 
does not have any active subsidiaries, except for those identified in the SEC 
Documents (as hereinafter defined).  Each of the Company and its subsidiaries 
is duly qualified as a foreign corporation to do business and is in good 
standing in every jurisdiction in which the nature of the business conducted 
or property owned by it makes such qualification necessary and where the 
failure so to qualify would have a Material Adverse Effect.  "Material Adverse 
Effect" means any  adverse effect on the operations, properties, prospects, or 
financial condition of the entity with respect to which such term is used and 
which is material to such entity and other entities controlling or controlled 
by such entity taken as a whole.

                 (b)  AUTHORIZATION; ENFORCEMENT.  (i) The Company has the 
requisite corporate power and authority to enter into and perform this 
Agreement and to issue the Shares and the Additional Shares in accordance with 
the terms hereof, (ii) the execution and delivery of this Agreement by the 
Company and the consummation by it of the transactions contemplated hereby 
have been duly authorized by all necessary corporate action, and no further 
consent or authorization of the Company or its Board of Directors or 
stockholders is required, (iii) this Agreement has been duly executed and 
delivered by the Company, and (iv) this Agreement constitutes a valid and 
binding obligation of the Company enforceable against the Company in 
accordance with its terms, except as such enforceability may be limited by 
applicable bankruptcy, insolvency, reorganization, moratorium, liquidation or 
similar laws relating to, or affecting generally the enforcement of, 
creditors' rights and remedies or by other equitable principles of general 
application.

                                 -7-

<PAGE>

                 (c)  CAPITALIZATION.  The authorized capital stock of the 
Company and the shares thereof currently issued and outstanding are as most 
recently described in the SEC Documents and there have been no changes (except 
for changes described on Exhibit A and additional option exercises under the 
Company's option plans) therein since such description. All of the outstanding 
shares of the Company's Common Stock have been validly issued and are fully 
paid and nonassessable.  Except as set forth in Exhibit A hereto and as 
described in the SEC Documents, no shares of Common Stock are entitled to 
preemptive rights and there are no outstanding options, warrants, scrip, 
rights to subscribe to, calls or commitments of any character whatsoever 
relating to, or securities or rights convertible into, any shares of capital 
stock of the Company, or contracts, commitments, understandings, or 
arrangements by which the Company is or may become bound to issue additional 
shares of capital stock of the Company or options, warrants, scrip, rights to 
subscribe to, or commitments to purchase or acquire, any shares, or securities 
or rights convertible into shares, of capital stock of the Company.  The 
Company has furnished to the Investors true and correct copies of the 
Company's Certificate of Incorporation as in effect on the date hereof (the 
"Certificate"), and the Company's By-Laws, as in effect on the date hereof 
(the "By-Laws").

                 (d)  ISSUANCE OF SHARES.  The issuance of the Shares and 
Additional Shares has been duly authorized and, when paid for or issued in 
accordance with the terms hereof, shall be validly issued, fully paid and non-
assessable.

                 (e)  NO CONFLICTS.  The execution, delivery and performance 
of this Agreement by the Company and the consummation by the Company of the 
transactions contemplated hereby do not and will not (i) result in a violation 
of the Company's Certificate or By-Laws or (ii) conflict with, or constitute a 
default (or an event which with notice or lapse of time or both would become a 
default) under, or give to others any rights of termination, amendment, 
acceleration or cancellation of, any agreement, indenture or instrument to 
which the Company is a party and which has previously been filed as an exhibit 
to the Company's Form 10-K for the year ended December 31, 1994 or any 
material agreement entered into subsequent thereto that is still in effect, or 
result in a violation of any federal, state, local or foreign law, rule, 
regulation, order, judgment or decree (including Federal and state securities 
laws and regulations) applicable to the Company, or by which any property or 
asset of the Company is bound or affected (except for such conflicts, 
defaults, terminations, amendments, accelerations, cancellations and 
violations as would not, individually or in the aggregate, have a Material 
Adverse Effect); provided that, for purposes of such representation as to 
Federal, state, local or foreign law, rule or regulation, no representation is 
made herein with respect to any of the same applicable solely to the Investors 
and not to the Company.  The business of the Company is not being conducted in 
violation of any law, ordinance or regulations of any governmental entity, 
except for possible violations which either singly or in the aggregate do not 
have a Material Adverse Effect.  The Company is not required under Federal, 
state or local law, rule or regulation in the United States to obtain any 
consent, authorization or order of, or make any filing or registration with, 
any court or governmental agency in order for it to execute, deliver or 
perform any of its obligations under this Agreement or issue and sell the 
Shares or the Additional Shares in accordance with the terms hereof (other 
than the filing of a Form D with the SEC, any filings required by the National 
Association of Securities Dealers, Inc. or their affiliated exchanges (the 
"NASD") or state securities filings which may be required to be made by the 
Company subsequent to the Closing, and any registration statement which may be 
filed in accordance with Section 1.5 herein); provided that, for purposes of 
the representation made in this sentence, the Company is assuming and relying 
upon the accuracy of the relevant representations and agreements of each 
Investor herein.

                                  -8-

<PAGE>

                 (f)  SEC DOCUMENTS, FINANCIAL STATEMENTS.  The Common Stock 
of the Company is registered pursuant to Section 12(g) of the Securities and 
Exchange Act of 1934, as amended (the "Exchange Act") and the Company has 
filed all reports, schedules, forms, statements and other documents required 
to be filed by it with the SEC pursuant to the reporting requirements of the 
Exchange Act, including material filed pursuant to Section 13(a) or 15(d), in 
addition to one or more registration statements and amendments thereto 
heretofore filed by the Company with the SEC (all of the foregoing filed prior 
to the date hereof, as well as the drafts of the Form 8-K with respect to the 
private placements of June 26, 1995 and July 7, 1995, being hereinafter 
referred to herein as the "SEC Documents").  The Company has delivered to the 
Investors true and complete copies of the quarterly and annual (including, 
without limitation, proxy information and solicitation materials) SEC 
Documents filed with the SEC since December 31, 1994.  The Company has not 
provided to the Investors any information which, according to applicable law, 
rule or regulation, should have been disclosed publicly by the Company but 
which has not been so disclosed, other than with respect to the transactions 
contemplated by this Agreement.  As of their respective dates, the SEC 
Documents complied in all material respects with the requirements of the 
Exchange Act and the rules and regulations of the SEC promulgated thereunder 
and other federal, state and local laws, rules and regulations applicable to 
such SEC Documents, and none of the SEC Documents contained any untrue 
statement of a material fact or omitted to state a material fact required to 
be stated therein or necessary in order to make the statements therein, in 
light of the circumstances under which they were made, not misleading.  The 
financial statements of the Company included in the SEC Documents comply as to 
form in all material respects with applicable accounting requirements and the 
published rules and regulations of the SEC or other applicable rules and 
regulations with respect thereto.  Such financial statements have been 
prepared in accordance with generally accepted accounting principles applied 
on a consistent basis during the periods involved (except (i) as may be 
otherwise indicated in such financial statements or the notes thereto or (ii) 
in the case of unaudited interim statements, to the extent they may not 
include footnotes or may be condensed or summary statements) and fairly 
present in all material respects the financial position of the Company as of 
the dates thereof and the results of operations and cash flows for the periods 
then ended (subject, in the case of unaudited statements, to normal year-end 
audit adjustments).

                 (g)  NO MATERIAL ADVERSE CHANGE.  Since December 31, 1994,  
the date through which the most recent annual report of the Company on Form 
10-K has been prepared and filed with the SEC, a copy of which is included in 
the SEC Documents, no Material Adverse Effect has  occurred or exists with 
respect to the Company except as otherwise disclosed or reflected in other SEC 
Documents prepared through or as of a date subsequent to December 31, 1994.

                 (h)  NO UNDISCLOSED LIABILITIES.  The Company has no 
liabilities or obligations not disclosed in the SEC Documents, other than 
those incurred in the ordinary course of the Company's business since March 
31, 1995 and which, individually or in the aggregate, do not or would not have 
a Material Adverse Effect on the Company.

                 (i)  NO UNDISCLOSED EVENTS OR CIRCUMSTANCES.  No event or 
circumstance has occurred or exists with respect to the Company or its 
business, properties, prospects, operations or financial condition, which, 
under applicable law, rule or regulation, requires public disclosure or 
announcement by the Company but which has not been so publicly announced or 
disclosed.

            Section 2.2  REPRESENTATIONS AND WARRANTIES OF THE INVESTORS.  
Each of the Investors hereby makes the following representations and 
warranties to the Company:

                                   -9-

<PAGE>

                 (a)  AUTHORIZATION; ENFORCEMENT.  (i) The Investor has the 
requisite power and authority to enter into and perform this Agreement and to 
purchase the Shares being sold hereunder, (ii) the execution and delivery of 
this Agreement by the Investor and the consummation by it of the transactions 
contemplated hereby have been duly authorized by all necessary corporate 
action, and no further consent or authorization of the Investor or its Board 
of Directors, stockholders, or partners as the case may be, is required, (iii) 
this Agreement has been duly authorized, executed and delivered by the 
Investor, and (iv) this Agreement constitutes a valid and binding obligation 
of the Investor enforceable against the Investor in accordance with its terms, 
except as enforceability may be limited by applicable bankruptcy, insolvency, 
reorganization, moratorium, liquidation or similar laws relating to, or 
affecting generally the enforcement of, creditors' rights and remedies or by 
other equitable principles of general application.

                 (b)  NO CONFLICTS.  The execution, delivery and performance 
of this Agreement and the consummation by the Investor of the transactions 
contemplated hereby or relating hereto do not and will not (i) result in a 
violation of the Investor's charter documents or By-Laws or (ii) conflict 
with, or constitute a default (or an event which with notice or lapse of time 
or both would become a default) under, or give to others any rights of 
termination, amendment, acceleration or cancellation of any agreement, 
indenture or instrument to which the Investor is a party, or result in a 
violation of any law, rule, or regulation, or any order, judgment or decree of 
any court or governmental agency applicable to the Investor or its properties 
(except for such conflicts, defaults and violations as would not, individually  
or in the aggregate have a Material Adverse Effect on the Investor).  The 
businesses of the Investor are not being conducted in violation of any law, 
ordinance or regulation of any governmental entity, except for possible 
violations which either singly or in the aggregate do not have a Material 
Adverse Effect.  The Investor is not required to obtain any consent, 
authorization or order of, or make any filing or registration with, any court 
or governmental agency in order for it to execute, deliver or perform any of 
its obligations under this Agreement or purchase the Shares or the Additional 
Shares in accordance with the terms hereof; provided that for purposes of the 
representation made in this sentence, the Investor is assuming and relying 
upon the accuracy of the relevant representations and agreements of the 
Company herein.

                 (c)  SOPHISTICATION.  The Investor has such knowledge and 
experience in financial and business matters that it is capable of evaluating 
the merits and risks of the investment contemplated by this Agreement.  The 
Investor has been afforded, to the satisfaction of the Investor, the 
opportunity to review the SEC Documents and obtain such additional publicly 
available information concerning the Company and its business, and to ask such 
questions and receive such answers (based upon publicly available 
information), as the Investor deems necessary to make an informed investment 
decision.

                 (d)  INVESTMENT REPRESENTATION.  The Investor is purchasing 
the Shares and, if any, the Additional Shares for investment purposes and not 
with a view towards distribution.  Investor has no present intention to sell 
the Shares or the Additional Shares and the Investor has no present 
arrangement (whether or not legally binding) at any time to sell the Shares or 
the Additional Shares to or through any person or entity; provided, however, 
except as provided in subsection (g) below, that by making the representations 
herein, the Investor does not agree to hold the Shares or the Additional 
Shares for any minimum or other specific term and reserves the right to 
dispose of the Shares or the Additional Shares at any time in accordance with 
Federal and state securities laws applicable to such disposition.

                                  -10-

<PAGE>

                 (e)  ACCREDITED INVESTOR.  The Investor is an accredited 
investor as defined in Regulation Section 230.501 promulgated under the Act.

                 (f)  RULE 144.  The Investor understands that the Shares and 
any Additional Shares must be held indefinitely unless such Shares or 
Additional Shares are subsequently registered under the Act or an exemption 
from registration is available.  The Investor has been advised or is aware of 
the provisions of Rule 144 promulgated under the Act.

                 (g)  LOCK-UP PERIOD.  Notwithstanding the foregoing, the 
Investor shall not sell (including a short sale), transfer or otherwise 
dispose of the Shares, or any Additional Shares issued to such Investor, at 
any time during the 160-day period following June 26, 1995.  The foregoing 
shall not preclude the Investor from entering into derivative transactions in 
the Shares so long as no Shares are used to cover the derivative position 
during the 160-day period.


                                  ARTICLE III

                                   Covenants
                                   ---------

            Section 3.1  SECURITIES COMPLIANCE.

                 (a)  The Company shall notify the SEC and the NASD, in 
accordance with their requirements, of the transactions contemplated by this 
Agreement, and shall take all other necessary action and proceedings as may be 
required and permitted by applicable law, rule and regulation, including, 
without limitation, the filing of a Form D with the SEC, for the legal and 
valid issuance of the Shares and the Additional Shares to the Investors.

                 (b)  Each Investor understands that the Shares and, if any, 
the Additional Shares, are being offered and sold to it in reliance on a 
transactional exemption from the registration requirements of Federal and 
state securities laws and that the Company is relying upon the truth and 
accuracy of the representations, warranties, agreements, acknowledgments and 
understandings of such Investor set forth herein in order to determine the 
applicability of such exemptions and the suitability of such Investor to 
acquire the Shares and, if any, the Additional Shares.

            Section 3.2  CORPORATE.

                 (a)  From the date hereof through the end of the Valuation 
Period the Company shall not (i) amend its Certificate or By-Laws so as to 
adversely affect any rights of the Investor; (ii) split, combine or reclassify 
its outstanding capital stock; (iii) declare or set aside or pay any dividend 
or other distribution with respect to the Company's outstanding Common Stock; 
(iv) issue or sell, directly or indirectly, shares of the Company's Common 
Stock in a manner or upon terms as could reasonably be expected to affect the 
market for the Common Stock materially and adversely; or (v) enter into any 
agreement with respect to the foregoing; and (vi) the Company shall at all 
times reserve and keep available, solely for issuance and delivery as Shares 
or Additional Shares hereunder, such shares of Common Stock as shall from time 
to time be issuable or reasonably be expected to be issuable as Shares or 
Additional Shares hereunder.

                                   -11-

<PAGE>

                 (b)  The Company will cause its Common Stock to continue to 
be registered under Sections 12(b) or 12(g) of the Exchange Act, will comply 
in all respects with its reporting and filing obligations under said act, will 
comply with all requirements related to any registration statement filed 
pursuant to Section 1.5 herein, and will not take any action or file any 
document (whether or not permitted by said Act or the rules thereunder) to 
terminate or suspend such registration or to terminate or suspend its 
reporting and filing obligations under said act, except as permitted herein.  
The Company will take all action necessary to continue the listing or trading 
of its Common Stock on the Nasdaq National Market and will comply in all 
respects with the Company's reporting, filing and other obligations under the 
bylaws or rules of the NASD and Nasdaq.


                                  ARTICLE IV

                                  Conditions
                                  ----------

            Section 4.1  CONDITIONS PRECEDENT TO THE OBLIGATION OF THE COMPANY 
TO SELL THE SHARES.  The obligation hereunder of the Company to issue and/or 
sell the Shares or the Additional Shares to the Investors is further subject 
to the satisfaction, at or before the respective issuance and deliveries 
thereof, of each of the following conditions set forth below.  These 
conditions are for the Company's sole benefit and may be waived by the Company 
at any time in its sole discretion.

                 (a)  ACCURACY OF THE INVESTORS REPRESENTATIONS AND 
WARRANTIES.  The representations and warranties of each Investor shall be true 
and correct in all material respects as of the date when made and as of the 
date of such issuance and delivery as though made at that time.

                 (b)  Performance by the Investors.  The Investors shall have 
performed, satisfied and complied in all material respects with all covenants, 
agreements and conditions required by this Agreement to be performed, 
satisfied or complied with by the Investors at or prior to such date.

                 (c)  NO INJUNCTION.  No statute, rule, regulation, executive 
order, decree, ruling or injunction shall have been enacted, entered, 
promulgated or endorsed by any court or governmental authority of competent 
jurisdiction which prohibits the consummation of any of the transactions 
contemplated by this Agreement.

            Section 4.2  CONDITIONS PRECEDENT TO THE OBLIGATION OF THE 
INVESTORS TO PURCHASE THE SHARES.  The obligation of each Investor hereunder 
to acquire and pay for the Shares is subject to the satisfaction, at or before 
the Closing of each of the following conditions set forth below.  These 
conditions are for the Investors' sole benefit and may be waived by the 
Investors at any time in their sole discretion.

                 (a)  ACCURACY OF THE COMPANY'S REPRESENTATIONS AND 
WARRANTIES.  The representations and warranties of the Company shall be true 
and correct in all material respects as of the date when made and as of the 
Closing Date as though made at that time (except for representations and 
warranties that speak as of a particular date).

                 (b)  PERFORMANCE BY THE COMPANY.  The Company shall have 
performed, satisfied and complied in all material respects with all covenants, 
agreements and conditions required 

                                  -12

<PAGE>

by this Agreement to be performed, satisfied or complied with by the Company 
at or prior to the Closing.

                 (c)  NASDAQ.  From the date hereof to the Closing Date, as to 
the Shares to be issued and delivered on the Closing Date, trading in the 
Company's Common Stock shall not have been suspended by the SEC or the Nasdaq 
National Market (except for any suspension of trading of limited duration 
agreed to between the Company and the Nasdaq National Market solely to permit 
dissemination of material information regarding the Company), and trading in 
securities generally as reported by Nasdaq shall not have been suspended or 
limited or minimum prices shall not have been established on securities whose 
trades are reported by Nasdaq.  Notwithstanding the foregoing sentence, in the 
event that at any point on or prior to the first day of the Valuation Period, 
trading in the Common Stock is suspended by the SEC or the Nasdaq National 
Market, (i) calculation of the Average Share Price shall be suspended for such 
period of time as trading in the Common Stock is suspended and (ii) the 
Valuation Period shall be reset so that such Valuation Period shall begin on 
the 160th calendar day following June 26, 1995 and shall end on the 45th 
calendar day thereafter for which quotations for the Company's Common Stock on 
the Nasdaq National Market have been available for a total of 45 calendar 
days.  In the event that the Company's Common Stock is delisted from the 
Nasdaq National Market at any time during the Valuation Period or in the event 
that trading in the Common Stock is suspended for a period of more than thirty 
(30) days subsequent to the commencement of the Valuation Period, (x) the 
Valuation Period will be deemed to have concluded on the date on which the 
Common Stock was delisted or such trading was suspended, (y) the Average Stock 
Price shall be calculated based on the number of days in such shortened 
Valuation Period, and (z) each Investor shall receive any Additional Shares 
owed to it pursuant to Section 1.3(c) herein within five (5) business days of 
the conclusion of the shortened Valuation Period.

                 (d)  NO INJUNCTION.  No statute, rule, regulation, executive 
order, decree, ruling or injunction shall have been enacted, entered, 
promulgated or endorsed by any court or governmental authority of competent 
jurisdiction which prohibits the consummation of any of the transactions 
contemplated by this Agreement.

                 (e)  OPINION OF COUNSEL, ETC.  At the Closing the Investors 
shall have received an opinion of Brobeck Phleger & Harrison, counsel to the 
Company, in form and substance satisfactory to the Investors and their counsel 
(in substantially the form of Exhibit C hereto), and such other certificates 
and documents as the Investors or their counsel shall reasonably require 
incident to the Closing.


                                   ARTICLE V

                                Legend on Stock
                                ---------------

            Each certificate representing the Shares or Additional Shares (if 
a registration statement is not effective with respect to the Additional 
Shares at the time of such issuance) issued pursuant to Section 1.3 shall be 
stamped or otherwise imprinted with a legend substantially in the following 
form:

            THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN 
            REGISTERED UNDER THE SECURITIES ACT OF 1933, AS 

                                 -13-

<PAGE>

            AMENDED (THE "ACT"), AND MAY NOT BE SOLD, OFFERED FOR SALE, 
            PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED UNLESS THERE 
            IS AN EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT COVERING 
            SUCH SECURITIES OR THE COMPANY RECEIVES AN OPINION OF 
            COUNSEL REASONABLY ACCEPTABLE TO THE COMPANY STATING THAT 
            SUCH SALE OR TRANSFER IS EXEMPT FROM THE REGISTRATION AND 
            PROSPECTUS DELIVERY REQUIREMENTS OF SUCH ACT.


                                   ARTICLE VI

                                  Termination
                                  -----------

            Section 6.1  TERMINATION BY MUTUAL CONSENT.  This Agreement may be 
terminated at any time prior to the Closing by the mutual consent of the 
Company and the Investors, by action of their respective Boards of Directors 
or other governing body.

            Section 6.2  OTHER TERMINATION.  This Agreement may be terminated 
by action of the Board of Directors or other governing body of the Investors 
or the Company at any time after July 12, 1995 if the Closing shall not have 
been consummated by July 12, 1995.

            Section 6.3  AUTOMATIC TERMINATION.  This Agreement shall 
automatically terminate without any further action of either party hereto if 
the Closing shall not have occurred by July 12, 1995.


                                  ARTICLE VII

                                 Miscellaneous
                                 -------------

            Section 7.1  FEES AND EXPENSES.  Each party shall pay the fees and 
expenses of its advisers, counsel, accountants and other experts, if any, and 
all other expenses incurred by such party incident to the negotiation, 
preparation, execution, delivery and performance of this Agreement, provided 
that the Company shall pay, at the Closing, all attorneys' fees and expenses 
incurred by the Investors and Cappello Capital Corp., up to a maximum of 
$2,500, in connection with the preparation, negotiation, execution and 
delivery of this Agreement and the transactions contemplated hereunder.  
Without limiting the generality of the foregoing, The Kriegsman Group shall be 
entitled to a finders fee pursuant to a separate agreement with respect 
thereto between such finder and the Company, and the Company shall be solely 
responsible for the full payment thereof and shall indemnify and hold harmless 
the Investors from and against all loss, cost, damage or expense arising 
therefrom.  The Company shall pay all stamp and other taxes and duties levied 
in connection with the issuance of the Shares or the Additional Shares 
pursuant hereto.

            Section 7.2  SPECIFIC ENFORCEMENT; CONSENT TO JURISDICTION.

                 (a)  The Company and the Investors acknowledge and agree that 
irreparable damage would occur in the event that any of the provisions of this 
Agreement were not performed in 

                                 -14-

<PAGE>

accordance with their specific terms or were otherwise breached.  It is 
accordingly agreed that the parties shall be entitled to an injunction or 
injunctions to prevent or cure breaches of the provisions of this Agreement 
and to enforce specifically the terms and provisions hereof, this being in 
addition to any other remedy to which either of them may be entitled by law 
or equity.

                 (b)  Each of the Company and the Investors (i) hereby 
irrevocably submits to the exclusive jurisdiction of the United States 
District Court and other courts of the United States sitting in California for 
the purposes of any suit, action or proceeding arising out of or relating to 
this  Agreement and (ii) hereby waives, and agrees not to assert in any such 
suit, action or proceeding, any claim that it is not personally subject to the 
jurisdiction of such court, that the suit, action or proceeding is brought in 
an inconvenient forum or that the venue of the suit, action or proceeding is 
improper.  Each of the Company and the Investors consents to process being 
served in any such suit, action or proceeding by mailing a copy thereof to 
such party at the address in effect for notices to it under this Agreement and 
agrees that such service shall constitute good and sufficient service of 
process and notice thereof.  Nothing in this paragraph shall affect or limit 
any right to serve process in any other manner permitted by law.

            Section 7.3  ENTIRE AGREEMENT; AMENDMENTS.  This Agreement 
contains the entire understanding of the parties with respect to the matters 
covered hereby and thereby and, except as specifically set forth herein, 
neither the Company nor the Investors makes any representation, warranty, 
covenant or undertaking with respect to such matters.  No provision of this 
Agreement may be waived or amended other than by a written instrument signed 
by the party against whom enforcement of any such amendment or waiver is 
sought.

            Section 7.4  NOTICES.  Any notice or other communication required 
or permitted to be given hereunder shall be in writing and shall be effective 
(a) upon hand delivery or delivery by telex (with correct answer back 
received), telecopy or facsimile at the address or number designated below (if 
delivered on a business day during normal business hours where such notice is 
to be received), or the first business day following such delivery (if 
delivered other than on a business day during normal business hours where such 
notice is to be received) or (b) on the second business day following the date 
of mailing by express courier service, fully prepaid, addressed to such 
address, or upon actual receipt of such mailing, whichever shall first occur.  
The addresses for such communications shall be:

            to the Company:

                     Advanced Tissue Sciences, Inc.
                     10933 North Torrey Pines Road
                     La Jolla, California 92037
                     Attn:  Chief Executive Officer

            with copies to:

                     Brobeck Phleger & Harrison
                     4675 MacArthur Court
                     Suite 1000
                     Newport Beach, California 92660
                     Attn:  Laura M. Brower, Esq.


                                  -15-

<PAGE>

            to the Investors:

                     c/o Kayne, Anderson Investment Management, Inc.
                     1800 Avenue of the Stars
                     Suite 1425
                     Los Angeles, California 90067
                     Attn:  Mr. Jerry R. Welch

            with copies to:

                     Cappello Capital Corp.
                     1299 Ocean Avenue, Suite 306
                     Santa Monica, California 90401
                     Attn:  Mr. Gerard K. Cappello

                     Milbank, Tweed, Hadley & McCloy
                     601 South Figueroa Street
                     Los Angeles, California 90017
                     Attn:  Eric Schunk, Esq.


Either party hereto may from time to time change its address for notices under 
this Section 7.4 by giving at least 10 days' written notice of such changed 
address to the other party hereto.

            Section 7.5  WAIVERS.  No waiver by either party of any default 
with respect to any provision, condition or requirement of this Agreement 
shall be deemed to be a continuing waiver in the future or a waiver of any 
other provision, condition or requirement hereof, nor shall any delay or 
omission of either party to exercise any right hereunder in any manner impair 
the exercise of any such right accruing to it thereafter.

            Section 7.6  HEADINGS.  The headings herein are for convenience 
only, do not constitute a part of this Agreement and shall not be deemed to 
limit or affect any of the provisions hereof.

            Section 7.7  SUCCESSORS AND ASSIGNS.  This Agreement shall be 
binding upon and inure to the benefit of the parties and their successors and 
assigns.  The parties hereto may amend this Agreement without notice to or the 
consent of any third party.  Except as otherwise provided herein, neither the 
Company nor the Investors shall assign this Agreement or any rights or 
obligations hereunder without the prior written consent of the other (which 
consent may be withheld for any reason in the sole discretion of the party 
from whom consent is sought); provided, however, that the Company may assign 
its rights and obligations hereunder to any acquirer of substantially all of 
the assets or a controlling equity interest of the Company.  The assignment by 
a party of this Agreement or any rights hereunder shall not affect the 
obligations of such party under this Agreement.

            Section 7.8  NO THIRD PARTY BENEFICIARIES.  This Agreement is 
intended for the benefit of the parties hereto and their respective permitted 
successors and assigns and is not for the benefit of, nor may any provision 
hereof be enforced by, any other person.

                                   -16-

<PAGE>

            Section 7.9  GOVERNING LAW.  This Agreement shall be governed by 
and construed and enforced in accordance with the internal laws of California 
without regard to the principles of conflict of laws.

            Section 7.10  SURVIVAL. The representations and warranties of the 
Company and the Investors contained in Article II and the agreements and 
covenants set forth in Articles I and III shall survive the Closing.

            Section 7.11  EXECUTION.  This Agreement may be executed in two or 
more counterparts, all of which shall be considered one and the same agreement 
and shall become effective when counterparts have been signed by each party 
and delivered to the other party, it being understood that both parties need 
not sign the same counterpart.  In the event any signature is delivered by 
facsimile transmission, the party using such means of delivery shall cause 
four additional executed signature pages to be physically delivered to the 
other party within five days of the execution and delivery hereof.

            Section 7.12  PUBLICITY.  The Company and the Investors shall 
consult and cooperate with each other in issuing any press releases or 
otherwise making public statements with respect to the transactions 
contemplated hereby, provided the foregoing shall not interfere with the legal 
obligations of either party with respect to public disclosure; and provided 
further, that neither the Company nor the Investors shall be required to 
consult with the other if any such press release or public statement does not 
specifically name the other.


                 [Remainder of page intentionally left blank.]

                                   -17-

<PAGE>

            IN WITNESS WHEREOF, the parties hereto have caused this Agreement 
to be duly executed by their respective authorized officers as of the date 
hereof.

                                   ADVANCED TISSUE SCIENCES, INC.


                                   By:  /s/  Arthur J. Benvenuto
                                        ----------------------------
                                          Name:  Arthur J. Benvenuto
                                          Its:   Chairman, President and 
                                                 Chief Executive Officer


                                   ARBCO ASSOCIATES, L.P., a California
                                     Limited Partnership

                                   OFFENSE GROUP ASSOCIATES, L.P.,
                                     a California Limited Partnership


                                   By:  KAIM Non-Traditional, L.P., a
                                          California Limited Partnership, 
                                          General Partner

                                   By:  Kayne, Anderson Investment 
                                          Management, Inc., a California 
                                          Corporation, General Partner


                                   By:  /s/  Jerry R. Welch
                                        -------------------------------------
                                          Jerry R. Welch,
                                          Senior Vice President

                                 -18-
<PAGE>


                                                             SCHEDULE I


                               LIST OF INVESTORS


     Name                             Number of Shares     Purchase Price
     ----                             ----------------     --------------

Arbco Associates, L.P.,
a California Limited Partnership         239,796            $1,645,000

Offense Group Associates, L.P.,
a California Limited Partnership         145,773             1,000,000
                                         -------            ----------

            Total:                       385,569            $2,645,000


                                 -19-
<PAGE>


                                                              EXHIBIT A

                             CAPITALIZATION SUMMARY


The following table reconciles the Company's outstanding Common Stock and 
options and warrants as reported in the Company's Quarterly Report on Form 10-
Q as of March 31, 1995 to June 13, 1995.

                                               Common       Options and
                                                Stock         Warrants
                                             Outstanding    Outstanding
                                             -----------    -----------

   Outstanding per Form 10-Q                  30,570,993     4,186,957
   Options and warrants exercised                561,200      (561,200)
   Options and warrants granted                        -       125,000
   Options and warrants canceled                       -      (139,209)
                                              ----------     ---------

   Outstanding as of June 13, 1995            31,132,193     3,611,548
                                              ==========     =========


As of June 13, 1995, the Company had 1,900,462 remaining available for grant 
under its 1992 Stock Option/Stock Issuance Plan.  Additional shares previously 
granted under the Plan have been exercised subsequent to June 13, 1995.

The Company issued an aggregate of 2,228,863 shares of Common Stock (subject 
to adjustment) on June 26, 1995 and July 7, 1995 (the "Private Placements").  
In connection with the Private Placements, the Company issued warrants to 
purchase 200,598 shares of Common Stock to certain investment advisors on 
June 26, 1995 and July 7, 1995 at an initial exercise price of $6.86 per 
share.  In addition, the Company will issue warrants to purchase 34,701 shares 
of Common Stock (subject to adjustment) to certain investment advisors 
involved in this transaction on the Closing Date at an initial exercise price 
of $6.86 per share.

On January 5, 1995, the Company's Board of Directors (the "Board") adopted a 
Shareholder Rights Plan (the "Rights Plan").  Pursuant to the Rights Plan, the 
Board declared a dividend of one preferred share purchase right (the "Right") 
for each share of Common Stock outstanding on January 20, 1995.  Each Right 
entitles the registered holder to purchase from the Company one-hundredth of a 
share of Series A Junior Participating Preferred Stock at an exercise price of 
$55 per one-hundredth share, subject to adjustment.

                                 -20-

<PAGE>

                                                        EXHIBIT B

                                             July 11, 1995

Advanced Tissue Sciences, Inc.
10933 North Torrey Pines Road
La Jolla, California 92037
Attention:  Mr. Arthur J. Benvenuto

            Re:     REGULATION D OFFERING

Ladies and Gentlemen:

            Reference is made to the Investment Agreement of even date and 
delivery herewith (the "Agreement") between the undersigned ("Investors") 
and Advanced Tissue Sciences, Inc.  Capitalized terms contained in this 
letter shall have the same meaning ascribed to them in the Agreement.

            In addition to the representations and covenants of the Investors 
contained in the Agreement, each of the Investors further covenant and agree 
as follows:

            1.  In the event the Investors engage in short sales transactions 
or other hedging activities during the period from 160 days following June 26, 
1995 through 205 days following June 26, 1995 which involve, among other 
things, sales of Common Stock of the Company, each Investor will, to the 
extent within its reasonable control, conduct such activities (a) in such a 
manner so as not to complete or effect any such sale on any trading day 
during such period at a price which is lower than the lowest sale effected 
on such day by persons other than the Investors and (b) only in such amounts 
that would not reasonably be expected to affect the market for the Common 
Stock materially and adversely.

            2.  Each Investor covenants that it will comply with all 
applicable laws, rules and regulations regarding the foregoing activities 
and/or the financing of the Shares and Additional Shares, including all 
applicable federal and state securities laws.

                                        Very truly yours,


                                        ARBCO ASSOCIATES, L.P., a California 
                                         Limited Partnership

                                        OFFENSE GROUP ASSOCIATES, L.P.,
                                         a California Limited Partnership

                                        By:  KAIM Non-Traditional, L.P., a
                                             California Limited Partnership, 
                                             General Partner

                                        By:  Kayne, Anderson Investment 
                                             Management, Inc., a California 
                                             Corporation, General Partner


                                        By:  /s/  Jerry R.Welch
                                            -------------------------------
                                             Jerry R. Welch
                                             Senior Vice President
 




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