ADVANCED TISSUE SCIENCES INC
8-K, 1995-07-10
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>
                     SECURITIES AND EXCHANGE COMMISSION
                          WASHINGTON, D.C. 20549


                                 FORM 8-K
                               ------------



                               CURRENT REPORT

 Pursuant to Section 13 or 15(d) of the Securities and Exchange Act of 1934


                               JUNE 26, 1995
                               Date of Report
                     (Date of earliest event reported)


                             ----------------


                       ADVANCED TISSUE SCIENCES, INC.
           (Exact name of registrant as specified in its charter)

                             -----------------



             Delaware                0-016607             14-1701513
- - -------------------------------    -----------         -------------------
(State or other jurisdiction of    (Commission         (I.R.S. Employer
  incorporation or organization)     File No.)         Identification No.)


    10933 North Torrey Pines Road, La Jolla, California       92037
    ---------------------------------------------------    ----------
         (Address of principal executive offices)          (Zip Code)


    Registrant's telephone number, including area code:  (619) 450-5730













<PAGE>
Item 5.  Other Events

     On June 26, 1995, Advanced Tissue Sciences, Inc. (the "Company") 
completed the private placement of 1,500,000 shares of its Common Stock 
(the "Shares") under Regulation D to the Securities Act of 1933, yielding 
the Company gross proceeds of approximately $10.3 million.  The Company 
intends to use the proceeds from this offering to complete the validation 
of its manufacturing facility, the up-scaling and validation of its 
manufacturing processes for Dermagraft-TC (trademark) for the treatment of 
severe burns and Dermagraft (trademark) for the treatment of diabetic foot 
ulcers, and other working capital and general corporate purposes.

The initial purchase price for the Shares was $6.86 per share, representing 
an 11.5% discount to the closing bid price of the Company's Common Stock on 
June 7, 1995.  However, the initial purchase price will be adjusted to 
result in a purchase price per share to the investors equal to 88.5% of the 
average closing price of the Common Stock during a period 90 to 135 
calendar days subsequent to the close of the transaction (the "Average 
Price").  To the extent 88.5% of the Average Price exceeds the initial 
purchase price of $6.86, the investors will provide additional proceeds 
such that the total proceeds to the Company from the investors equals the 
product of the 88.5% of the Average Price and the Shares.  If 88.5% of the 
Average Price is below the initial purchase price of $6.86, additional 
shares will be issued to the investors such that the purchase per share to 
the investors equals 88.5% of the Average Price.

In addition, if 88.5% of the Average Price is less than $6.86 per share and 
the Company issues or sells any shares of its Common Stock or any of its 
securities which are convertible into or exchangeable for its Common Stock 
or any warrants, options or other rights to subscribe for or purchase 
Common Stock within 135 calendar days of the close of the transaction at a 
purchase price less than $6.86 per share, then additional shares will be 
issued to result in a purchase price per share to the investors equal to 
the lower of (i) 88.5% of the Average Price or (ii) the lowest price per 
share the Company issues or sells any of the securities referred to above.  
This adjustment is exclusive of shares or options issued pursuant to the 
Company's option plans or shares issued upon the exercise of options, 
warrants or rights outstanding on the closing date of the transaction.

The Shares have not been registered under the Securities Act of 1933 or 
applicable state securities laws, and may not be offered or sold in the 
United States absent registration under such Act and applicable state 
securities laws or in reliance on available exemptions from such 
registration requirements.  However, the investors have certain 
registration rights, including agreement by the Company to register the 
Shares within 105 calendar days following the close of the transaction.

The Investment Agreements between the Company and each of S.P. Investors 
International S.A., Steinhardt Overseas Fund Ltd. and Gershon Partners 
L.P., each dated June 23, 1995, are attached hereto as exhibits and are 
incorporated herein by reference.  The foregoing summary is qualified in it 
entirety by reference to such exhibits.

In connection with the offering, the Company also issued warrants (the 
"Warrants") to purchase 90,000 and 45,000 shares, respectively, to 
designees of Cappello Capital Corp. ("Cappello") and The Kriegsman Group 
("Kriegsman").  Cappello acted as a financial advisor to the Company and 
Kriegsman as a finder with respect to the offering.  Cappello also received 
a cash commission and Kriegsman a finder's fee.  The Warrants are subject 
to adjustment in the same manner as the Shares.  In addition, Cappello and 
Kriegsman have certain piggyback registration rights related to the 
Warrants.

                                  2

<PAGE>
Item 7.  EXHIBITS

Exhibit
Number                         Description
- - -------                        -----------

4.1        Investment Agreement between Advanced Tissue Sciences,
           Inc. and S.P. Investors International S.A. dated 
           June 23, 1995

4.2        Investment Agreement between Advanced Tissue Sciences,
           Inc. and Steinhardt Overseas Fund Ltd. dated June 23, 1995

4.3        Investment Agreement between Advanced Tissue Sciences,
           Inc. and Gershon Partners L.P. dated June 23, 1995

4.4        Form of Warrant Agreement between the Company and each
           of Linda S. Cappello, Gerard K. Cappello, Lawrence K.
           Fleischman and The Kriegsman Group



                                SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, 
the registrant has duly caused this report to be signed on its behalf by 
the undersigned hereunto duly authorized.


                                    ADVANCED TISSUE SCIENCES, INC.


Date:  July 10 , 1995               By: /s/ Arthur J. Benvenuto
                                        ----------------------------------
                                       Arthur J. Benvenuto
                                       Chairman, President and 
                                       Chief Executive Officer

                                	3
<PAGE>

                             EXHIBIT INDEX

Exhibit No.                                                            Page
- - -----------                                                            ----

4.1     Investment Agreement between Advanced Tissue Sciences, Inc.
        and S.P. Investors International S.A. dated June 23, 1995

4.2     Investment Agreement between Advanced Tissue Sciences, Inc.
        and Steinhardt Overseas Fund Ltd. dated June 23, 1995

4.3     Investment Agreement between Advanced Tissue Sciences, Inc.
        and Gershon Partners L.P. dated June 23, 1995

4.4     Form of Warrant Agreement between the Company and each of
        Linda S. Cappello, Gerard K. Cappello, Lawrence K.
        Fleischman and The Kriegsman Group



<PAGE>
                                                        Exhibit 4.1
                                                                              

                          INVESTMENT AGREEMENT


                                Between



                     ADVANCED TISSUE SCIENCES, INC.



                                  And


                    S. P. INVESTORS INTERNATIONAL S.A.



                        Dated as of June 23, 1995







     THE SECURITIES TO BE PURCHASED AND SOLD PURSUANT TO THIS INVESTMENT 
AGREEMENT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS 
AMENDED, (THE "ACT") OR ANY STATE SECURITIES LAWS.  THEY MAY NOT BE OFFERED 
OR SOLD IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THE 
SECURITIES UNDER SAID ACT AND ANY APPLICABLE STATE SECURITIES LAW OR AN 
APPLICABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE ACT.

<PAGE>

      INVESTMENT AGREEMENT dated as of June 23, 1995 between S. P. Investors 
International S.A. (the "Investor") and Advanced Tissue Sciences, Inc., a 
corporation organized and existing under the laws of the State of Delaware 
(the "Company").

            WHEREAS, the parties desire that the Investor become an equity 
investor in the Company by purchasing an aggregate of 500,000 shares of the 
Company's Common Stock, par value $.01 per share (the "Common Stock").

            NOW, THEREFORE, the parties hereto agree as follows:


                                ARTICLE I

                    Purchase and Sale of Common Stock
                    ---------------------------------

            Section 1.1  PURCHASE AND SALE OF COMMON STOCK.  Upon the terms 
and conditions set forth herein, the Company shall issue and sell to the 
Investor, and the Investor shall purchase from the Company, 500,000 shares 
of the Company's Common Stock (the "Shares").

            Section 1.2  PURCHASE PRICE.  The aggregate purchase price for 
the Shares (the "Purchase Price") shall equal $3,430,000 payable in cash by 
wire transfer or cashier's check in immediately available funds.

            Section 1.3  SHARE NUMBER; VALUATION PERIOD.

                 (a)  The number of Shares that the Company shall be 
obligated to issue and sell and the Investor shall be obligated to purchase 
hereunder, in the aggregate, is referred to herein as the "Share Number."  
Subject to adjustment as provided in Sections 1.3(c), 1.3(d) and 1.3(e), the 
Share Number shall initially be 500,000.

                 (b)  The "Valuation Period" shall be a 45 calendar day 
period commencing on and including the first business day which is 90 
calendar days after the Closing Date (as defined herein) as the same may 
be modified pursuant to Section 4.2(c) hereof.

                 (c)  Notwithstanding Section 1.3(a) above, and except as 
hereinafter provided, if the Average Share Price (hereinafter defined) during 
the Valuation Period is less than $7.75, then the Company shall deliver to 
the Investor, at no additional cost to the Investor, and in addition to the 
initial Share Number, the number of shares of Common Stock that is obtained 
by subtracting (x) 500,000 from (y) the quotient obtained by dividing the 
Purchase Price by 88.5% of the Average Share Price (rounded to the nearest 
whole number) (together with any additional shares issued pursuant to 
Section 1.3(e) herein, the "Additional Shares").

                 (d)  Notwithstanding Section 1.3(a) above, and except as 
hereinafter provided, if the Average Share Price during the Valuation Period 
is greater than $7.75, the Investor shall pay to the Company the dollar 
amount by which (x) the product of 88.5% of the Average Share Price and the 
Share Number exceeds (y) the product of $6.86 and the Share Number.

                 (e)  Notwithstanding Section 1.3(c) above, in the event that 
the Company, on or prior to 135 days from the Closing Date, issues or sells 
any shares of its Common Stock or any
 
                                 -2-
<PAGE>
of its securities which are convertible into or exchangeable for its Common 
Stock or any warrants or other rights to subscribe for or to purchase or any 
options for the purchase of, its Common Stock (other than shares or options 
issued pursuant to the Company's option plans or shares issued upon exercise 
of options, warrants or rights outstanding on the Closing Date or as provided 
on EXHIBIT A hereto), at a purchase price which is less than $6.86 per share 
(the "Subsequent Sale Price"), then the Company shall deliver to the 
Investor, at no additional cost to the Investor, and in addition to the Share 
Number, the number of shares of Common Stock that is obtained by subtracting 
(x) 500,000 from (y) the quotient obtained by dividing the Purchase Price by 
the Subsequent Sale Price (rounded to the nearest whole number).

                 Notwithstanding any of the foregoing, the number of 
Additional Shares issuable hereunder shall be the greater of the number of 
Additional Shares issuable pursuant to Section 1.3(c) herein and the number 
of Additional Shares issuable pursuant to Section 1.3(e) herein, if any.

                 (f)  For purposes hereof, the Average Share Price shall 
mean the average of the closing trading prices of the Company's Common 
Stock on the Nasdaq National Market, as reported by the Nasdaq National 
Market for each trading day during the Valuation Period.

            Section 1.4  THE CLOSING.

                 (a)  The closing of the purchase and sale of the Shares (the 
"Closing"), shall take place (a) at the offices of the Investor, at 
10:00 a.m., local time on the later of the following:  (i) June 23, 1995, 
and (ii) the date on which the last to be fulfilled or waived of the 
conditions set forth in Article IV hereof and applicable to the Closing shall 
be fulfilled or waived in accordance herewith, or (b) at such other time and 
place and/or on such other date as the Investor and the Company may agree.  
The date on which the Closing occurs is referred to herein as the "Closing 
Date."

                 (b)  (i) On the Closing Date, the Company shall deliver to 
the Investor certificates representing the Share Number to be issued and sold 
to the Investor on such date and registered in the name of the Investor or 
deposit such Share Number into the accounts designated by the Investor and 
(ii) on the Closing Date, the Investor shall deliver to the Company the 
Purchase Price by cashier's check or wire transfer in immediately available 
funds to such account as shall be designated in writing by the Company.  
In addition, each of the Company and the Investor shall deliver all 
documents, instruments and writings required to be delivered by either of 
them pursuant to this Agreement at or prior to the Closing.

            Section 1.5.  COVENANT TO REGISTER.  For purposes of this 
Section 1.5, the following definitions shall apply:

                 (a)  (i)  The terms "register," "registered," and 
"registration" refer to a registration under the Act effected by preparing 
and filing a registration statement or similar document in compliance with 
the Act, and the declaration or ordering of effectiveness of such 
registration statement, document or amendment thereto.

                     (ii)  The term "Registrable Securities" means the Shares 
and any Additional Shares issued pursuant to Section 1.3 hereof and any 
securities of the Company or securities of any successor corporation issued 
as, or issuable upon the conversion or exercise of any warrant, right or 
other security that is issued as a dividend or other distribution with 
respect to, or in 

                                 -3-
<PAGE>
exchange for, or in replacement of, the Shares and any Additional Shares 
issued pursuant to Section 1.3 hereof.

                 (b)  (i)  The Company shall, as expeditiously as possible 
following the Closing, file a registration statement on Form S-3 or an 
equivalent thereof promptly after the Closing Date, covering all the 
Registrable Securities, and shall use its best efforts to cause such 
registration statement to become effective within 105 days of the Closing 
Date (the "Initial Registration").  In the event such registration is not so 
declared effective, the holder of the Registrable Securities shall have the 
right to require by notice in writing that the Company register all or any 
part of the Registrable Securities held by such holder (a "Demand 
Registration") and the Company shall thereupon effect such registration in 
accordance herewith.  The parties agree that if the holder of Registrable 
Securities demands registration of less than all of the Registrable 
Securities, the Company, at its option, may nevertheless file a registration 
statement covering all of the Registrable Securities.  If such registration 
statement is declared effective with respect to all Registrable Securities 
the demand registration rights granted pursuant to this Section 1.5 (b) 
(i) shall cease.  If such registration statement is not declared effective 
with respect to all Registrable Securities the demand registration rights 
described herein shall remain in effect until all Registrable Securities 
have been registered under the Act.

                     (ii)  The Company shall not be obligated to effect 
Demand Registration (i) if all of the Registrable Securities held by the 
holder of Registrable Securities which are intended to be covered by the 
Demand Registration are, at the time of the request of a Demand Registration,
included in an effective registration statement and the Company is in 
compliance with its obligations under Subsection (d) (ii) through (v) hereof.

                     (iii)  The Company may suspend the effectiveness of any 
such registration effected pursuant to this Section 1.5(b) in the event, and 
for such period of time as, such a suspension is required by the rules and 
regulations of the Securities and Exchange Commission ("SEC").

                     (iv)  If the registration statement covering the 
Registrable Securities is not effective within 105 days of the Closing, then 
the Company shall pay the Investor a one time penalty of 1.0% of the Purchase 
Price.

                 (c)  If the Company proposes to register (including for 
this purpose a registration effected by the Company for shareholders other 
than the Investor) any of its stock or other securities under the Act in 
connection with a public offering of such securities (other than a 
registration on Form S-4, Form S-8 or other limited purpose form) and the 
Registrable Securities have not heretofore been included in a registration 
statement under Subsection (b), which remains effective, the Company shall, 
at such time, promptly give the holder of Registrable Securities written 
notice of such registration.  Upon the written request of the holder of 
Registrable Securities given within twenty (20) days after receipt of such 
notice by the holder of Registrable Securities, the Company shall use its 
best efforts to cause to be registered under the Act all Registrable 
Securities that the holder of Registrable Securities requests to be 
registered.  However, the Company shall have no obligation under this 
Subsection (c) to the extent that, with respect to a public offering 
registration, any underwriter of such public offering reasonably requests 
that the Registrable Securities or a portion thereof be excluded therefrom.

                 (d)  Whenever required under this Section 1.5 to effect the 
registration of any Registrable Securities, including, without limitation, 
the Initial Registration, the Company shall, as expeditiously as reasonably 
possible:

                                -4-
<PAGE>
                     (i)  Prepare and file with the SEC a registration 
statement with respect to such Registrable Securities and use its best 
efforts to cause such registration to become effective and, upon the request 
of the Investor, keep such registration statement effective, pursuant to the 
provisions of Regulation Section 230.415 or otherwise, for so long as the 
holder of Registrable Securities desires to dispose of the securities covered 
by such registration statement (but not after the holder of Registrable 
Securities, in the reasonable opinion of its counsel, is free to sell such 
securities in any three month period under the provisions of Rule 144 under 
the Act).

                     (ii)  Prepare and file with the SEC such amendments and 
supplements to such registration statement and the prospectus used in 
connection with such registration statement as may be necessary to comply 
with the provisions of the Act with respect to the disposition of all 
securities covered by such registration statement.

                     (iii)  Furnish to the holder of Registrable Securities 
such numbers of copies of a prospectus, including a preliminary prospectus, 
in conformity with the requirements of the Act, and such other documents as 
the holder of Registrable Securities may reasonably require in order to 
facilitate the disposition of Registrable Securities owned by the holder of 
Registrable Securities.

                     (iv)  Use its best efforts to register and qualify the 
securities covered by such registration statement under such other securities 
or "Blue Sky" laws of such jurisdictions as shall be reasonably requested by 
the holder of Registrable Securities, provided that the Company shall not be 
required in connection therewith or as a condition thereto to qualify to do 
business or to file a general consent to service and process in any such 
states or jurisdictions.

                     (v)  Notify the holder of Registrable Securities of the 
happening of any event as a result of which the prospectus included in such 
registration statement, as then in effect, includes an untrue statement of 
material fact or omits to state a material fact required to be stated therein 
or necessary to make the statements therein not misleading in light of the 
circumstances then existing.

                     (vi)  Furnish, at the request of the holder of 
Registrable Securities, an opinion of counsel of the Company, dated the 
effective date of the registration statement, as to the due authorization 
and issuance of the securities being registered and compliance with 
securities laws by the Company in connection with the authorization and 
issuance thereof.

                     (vii)  Use its best efforts to list the Registrable 
Securities covered by such registration statement with any securities 
exchange on which the Common Stock is then listed;

                     (viii)  Make available for inspection by the holder of 
Registrable Securities, upon request, all SEC Documents filed subsequent to 
the Closing and require the Company's officers, directors and employees to 
supply all information reasonably requested by any holder of Registrable 
Securities in connection with such registration statement.

                 (e)  The holder of Registrable Securities will furnish to 
the Company in connection with any registration under this Section 1.5 such 
information regarding itself, the Registrable Securities and other securities 
of the Company held by it, and the intended method of disposition of such 
securities as shall be required to effect the registration of the Registrable 
Securities held by holder of Registrable Securities.

                                 -5-
<PAGE>
                 (f)  (i)  The Company shall indemnify, defend and hold 
harmless each holder of Registrable Securities which are included in a 
registration statement pursuant to the provisions of Subsections (b) or 
(c) from and against, and shall reimburse such holder with respect to, any 
and all claims, suits, demands, causes of action, losses, damages, 
liabilities, costs or expenses ("Liabilities") to which such holder may 
become subject under the Act or otherwise, arising from or relating to 
(A) any untrue statement or alleged untrue statement of any material fact 
contained in such registration statement, any prospectus contained therein 
or any amendment or supplement thereto, or (B) the omission or alleged 
omission to state therein a material fact required to be stated therein or 
necessary to make the statements therein, in light of the circumstances in 
which they were made, not misleading; provided, however, that the Company 
shall not be liable in any such case to the extent that any such Liability 
arises out of or is based upon an untrue statement or alleged untrue 
statement or omission or alleged omission so made in conformity with 
information furnished by such holders in writing specifically for use in 
the preparation thereof.

                     (ii)  Promptly after receipt by the holder of 
Registrable Securities of notice of the commencement of any action, the 
holder of Registrable Securities shall, if a claim in respect thereof is to 
be made against the Company hereunder, notify the Company in writing thereof, 
but the omission so to notify the Company shall not relieve the Company from 
any Liability which it may have to the holder of Registrable Securities other 
than under this section and shall only relieve it from any Lability which it 
may have to the holder of Registrable Securities under this section if and 
to the extent the Company is prejudiced by such omission.  In case any such 
action shall be brought against the holder of Registrable Securities and the 
holder of Registrable Securities shall notify the Company of the commencement 
thereof, the Company shall be entitled to participate in and, to the extent 
it shall wish, to assume and undertake the defense thereof with counsel 
reasonably satisfactory to the holder of Registrable Securities, and, after 
notice from the Company to the holder of Registrable Securities of its 
election so to assume and undertake the defense thereof, the Company shall 
not be liable to the holder of Registrable Securities under this section for 
any legal expenses subsequently incurred by the holder of Registrable 
Securities in connection with the defense thereof other than reasonable 
costs of investigation and of liaison with counsel so selected, PROVIDED, 
HOWEVER, that if the defendants in any such action include both the Company 
and the holder of Registrable Securities and the holder of Registrable 
Securities shall have reasonably concluded that there may be reasonable 
defenses available to it which are different from or additional to those 
available to the Company or if the interests of the holder of Registrable 
Securities reasonably may be deemed to conflict with the interests of the 
Company, the holder of Registrable Securities shall have the right to select 
a separate counsel and to assume such legal defenses and otherwise to 
participate in the defense of such action, with the expenses and fees of 
such separate counsel and other expenses related to such participation to 
be reimbursed by the Company as incurred.

                 (g)  (i)  With respect to the inclusion of Registrable 
Securities in a registration statement pursuant to subsections (b) or 
(c), all fees, costs and expenses of and incidental to such registration, 
inclusion and public offering shall be borne by the Company; provided, 
however, that any securityholders participating in such registration shall 
bear their pro rata share of the underwriting discounts and commissions, if 
any, incurred in connection with such registration.

                     (ii)  The fees, costs and expenses of registration to be 
borne by the Company as provided in this Subsection (g) shall include, 
without limitation, all registration, filing and NASD fees, printing 
expenses, fees and disbursements of counsel and accountants for the Company, 
and all legal fees and disbursements and other expenses of complying with 
state securities or Blue Sky laws of any jurisdiction or jurisdictions in 
which securities to be offered are to be 

                                -6-
<PAGE>
registered and qualified.  Fees and disbursements of counsel and accountants 
for the selling securityholders shall, however, be borne by the respective 
selling securityholder.

                 (h)  (i) The rights to cause the Company to register all or 
any portion of Registrable Securities pursuant to this Section 1.5 may be 
assigned by Investor to a transferee or assignee of 20% or more, in the 
aggregate, of the Shares and the Additional Shares.  Within a reasonable 
time after such transfer the Investor shall notify the Company of the name 
and address of such transferee or assignee and the securities with respect 
to which such registration rights are being assigned.  Such assignment shall 
be effective only if immediately following such transfer the further 
disposition of such securities by the transferee or assignee is restricted 
under the Act.  Any transferee shall agree in writing at the time of 
transfer to be bound by the provisions of this Section 1.5.

                     (ii)  From and after the date of this Agreement, the 
Company shall not agree to allow the holders of any securities of the Company 
to include any of their securities in any registration statement filed by the 
Company pursuant to Subsection (b) unless the inclusion of such securities 
will not reduce the amount of the Registrable Securities included therein.

            Section 1.6.  ADJUSTMENTS.  If the Investor shall be entitled to 
the issuance of Additional Shares, the Company shall deliver to the Investor 
at the offices of the Investor on the third (3rd) business day after the end 
of the Valuation Period one or more certificates representing the Additional 
Shares so to be delivered in accordance with this Agreement, registered in 
the name of the Investor, or deposit such Additional Shares into accounts 
designated by the Investor; provided, however, that if the sum of the shares 
then beneficially owned by the Investor , and any Additional Shares then 
issuable to the Investor, as determined by the Investor, in its sole 
determination, shall equal 1.66% or more of the shares of Company's Common 
Stock issued and outstanding (as determined in accordance with Section 13(d) 
of the Securities Exchange Act of 1934) just prior to the Closing, then, and 
in such event, (x) the number of Additional Shares to be issued to the 
Investor pursuant to this paragraph shall be reduced to the number which, 
together with the Share Number, shall equal 1.64% of the shares of the 
Company's Common Stock issued and outstanding (as so determined) just prior 
to the Closing, and (y) in consideration for such reduction in Additional 
Shares, the Company shall pay to the Investor a sum equal to the greater of 
(a) the product of 88.5% of the Average Share Price and the reduction in the 
Additional Shares to be issued as a result of the preceding clause (x), and 
(b) the product of the Subsequent Sale Price and the reduction in the 
Additional Shares to be issued as a result of the preceding clause (x).

            Section 1.7  RESCHEDULING.  If after the date hereof and prior to 
the expiration of the Valuation Period any person shall (a) publicly announce 
a tender offer or exchange offer for the Company's Common Stock, or 
(b) publicly announce plans for a merger, consolidation or potential change 
in control of the Company, the Investor may in its sole discretion elect by 
written notice to the Company to shorten the Valuation Period so as to end 
on a date which is either before or after the consummation of the record date 
for the consummation of any such transaction, which election must be made 
prior to consummation of any such transaction.  For purposes of the 
foregoing, it is understood and agreed that the Investor may, but shall not 
be required to, reduce or entirely eliminate the Valuation Period or to 
reschedule the Valuation Period.


                                  -7-
<PAGE>
                               ARTICLE II

                     Representations and Warranties
                     ------------------------------

            Section 2.1  REPRESENTATIONS AND WARRANTIES OF THE COMPANY.  The 
Company hereby makes the following representations and warranties to the 
Investor:

                 (a)  ORGANIZATION AND QUALIFICATION.  The Company is a 
corporation duly incorporated and existing in good standing under the laws of 
the State of Delaware, and has the requisite corporate power to own its 
properties and to carry on its business as now being conducted.  The Company 
does not have any active subsidiaries, except for those identified in the 
SEC Documents (as hereinafter defined).  Each of the Company and its 
subsidiaries is duly qualified as a foreign corporation to do business and 
is in good standing in every jurisdiction in which the nature of the business 
conducted or property owned by it makes such qualification necessary and 
where the failure so to qualify would have a Material Adverse Effect.  
"Material Adverse Effect" means any  adverse effect on the operations, 
properties, prospects, or financial condition of the entity with respect to 
which such term is used and which is material to such entity and other 
entities controlling or controlled by such entity taken as a whole.

                 (b)  AUTHORIZATION; ENFORCEMENT.  (i)  The Company has the 
requisite corporate power and authority to enter into and perform this 
Agreement and to issue the Shares and the Additional Shares in accordance 
with the terms hereof, (ii) the execution and delivery of this Agreement by 
the Company and the consummation by it of the transactions contemplated 
hereby have been duly authorized by all necessary corporate action, and no 
further consent or authorization of the Company or its Board of Directors or 
stockholders is required, (iii) this Agreement has been duly executed and 
delivered by the Company, and (iv) this Agreement constitutes a valid and 
binding obligation of the Company enforceable against the Company in 
accordance with its terms, except as such enforceability may be limited by 
applicable bankruptcy, insolvency, reorganization, moratorium, liquidation 
or similar laws relating to, or affecting generally the enforcement of, 
creditors' rights and remedies or by other equitable principles of general 
application.

                 (c)  CAPITALIZATION.  The authorized capital stock of the 
Company  and the shares thereof currently issued and outstanding are as most 
recently described in the SEC Documents and there have been no changes 
(except for changes described on EXHIBIT A) therein since such description. 
All of the outstanding shares of the Company's Common Stock have been validly 
issued and are fully paid and nonassessable.  Except as set forth in 
EXHIBIT A hereto and as described in the SEC Documents, no shares of Common 
Stock are entitled to preemptive rights and there are no outstanding options, 
warrants, scrip, rights to subscribe to, calls or commitments of any 
character whatsoever relating to, or securities or rights convertible into, 
any shares of capital stock of the Company, or contracts, commitments, 
understandings, or arrangements by which the Company is or may become bound 
to issue additional shares of capital stock of the Company or options, 
warrants, scrip, rights to subscribe to, or commitments to purchase or 
acquire, any shares, or securities or rights convertible into shares, of 
capital stock of the Company.  The Company has furnished to the Investor 
true and correct copies of the Company's Certificate of Incorporation as in 
effect on the date hereof (the "Certificate"), and the Company's By-Laws, as 
in effect on the date hereof (the "By-Laws").

                 (d)  ISSUANCE OF SHARES.  The issuance of the Shares and 
Additional Shares has been duly authorized and, when paid for or issued in 
accordance with the terms hereof, shall be validly issued, fully paid and 
non-assessable.

                                  -8-
<PAGE>

                 (e)  NO CONFLICTS.  The execution, delivery and performance 
of this Agreement by the Company and the consummation by the Company of the 
transactions contemplated hereby do not and will not (i) result in a 
violation of the Company's Certificate or By-Laws or (ii) conflict with, or 
constitute a default (or an event which with notice or lapse of time or both 
would become a default) under, or give to others any rights of termination, 
amendment, acceleration or cancellation of, any agreement, indenture or 
instrument to which the Company is a party and which has previously been 
filed as an exhibit to the Company's Form 10-K for the year ended 
December 31, 1994 and is still in effect, or result in a violation of any 
federal, state, local or foreign law, rule, regulation, order, judgment or 
decree (including Federal and state securities laws and regulations) 
applicable to the Company, or by which any property or asset of the Company 
is bound or affected (except for such conflicts, defaults, terminations, 
amendments, accelerations, cancellations and violations as would not, 
individually or in the aggregate, have a Material Adverse Effect); provided 
that, for purposes of such representation as to Federal, state, local or 
foreign law, rule or regulation, no representation is made herein with 
respect to any of the same applicable solely to the Investor and not to the 
Company.  The business of the Company is not being conducted in violation of 
any law, ordinance or regulations of any governmental entity, except for 
possible violations which either singly or in the aggregate do not have a 
Material Adverse Effect.  The Company is not required under Federal, state 
or local law, rule or regulation in the United States to obtain any consent, 
authorization or order of, or make any filing or registration with, any court 
or governmental agency in order for it to execute, deliver or perform any of 
its obligations under this Agreement or issue and sell the Shares or the 
Additional Shares in accordance with the terms hereof (other than the filing 
of a Form D with the SEC, any NASD filings or state securities filings which 
may be required to be made by the Company subsequent to the Closing, and 
any registration statement which may be filed in accordance with Section 1.5 
herein); provided that, for purposes of the representation made in this 
sentence, the Company is assuming and relying upon the accuracy of the 
relevant representations and agreements of the Investor herein.

                 (f)  SEC DOCUMENTS, FINANCIAL STATEMENTS.  The Common Stock 
of the Company is registered pursuant to Section 12(g) of the Securities and 
Exchange Act of 1934, as amended (the "Exchange Act") and the Company has 
filed all reports, schedules, forms, statements and other documents required 
to be filed by it with the SEC pursuant to the reporting requirements of the 
Exchange Act, including material filed pursuant to Section 13(a) or 15(d), 
in addition to one or more registration statements and amendments thereto 
heretofore filed by the Company with the SEC (all of the foregoing filed 
prior to the date hereof being hereinafter referred to herein as the "SEC 
Documents").  The Company has delivered to the Investor true and complete 
copies of the quarterly and annual (including, without limitation, proxy 
information and solicitation materials) SEC Documents filed with the SEC 
since December 31, 1994.  The Company has not provided to the Investor any 
information which, according to applicable law, rule or regulation, should 
have been disclosed publicly by the Company but which has not been so 
disclosed, other than with respect to the transactions contemplated by this 
Agreement.  As of their respective dates, the SEC Documents complied in all 
material respects with the requirements of the Exchange Act and the rules 
and regulations of the SEC promulgated thereunder and other federal, state 
and local laws, rules and regulations applicable to such SEC Documents, and 
none of the SEC Documents contained any untrue statement of a material fact 
or omitted to state a material fact required to be stated therein or 
necessary in order to make the statements therein, in light of the 
circumstances under which they were made, not misleading.  The financial 
statements of the Company included in the SEC Documents comply as to form in 
all material respects with applicable accounting requirements and the 
published rules and regulations of the SEC or other applicable rules and 
regulations with respect thereto.  Such financial statements have been 
prepared in accordance with generally accepted accounting principles applied 
on a consistent basis during the periods involved (except (i) as may be 
otherwise indicated in 

                                  -9-
<PAGE>
such financial statements or the notes thereto or (ii) in the case of 
unaudited interim statements, to the extent they may not include footnotes 
or may be condensed or summary statements) and fairly present in all 
material respects the financial position of the Company as of the dates 
thereof and the results of operations and cash flows for the periods then 
ended (subject, in the case of unaudited statements, to normal year-end 
audit adjustments).

                 (g)  NO MATERIAL ADVERSE CHANGE.  Since December 31, 1994,  
the date through which the most recent annual report of the Company on 
Form 10-K has been prepared and filed with the SEC, a copy of which is 
included in the SEC Documents, no Material Adverse Effect has occurred or 
exists with respect to the Company except as otherwise disclosed or reflected 
in other SEC Documents prepared through or as of a date subsequent to 
December 31, 1994.

                 (h)  NO UNDISCLOSED LIABILITIES.  The Company has no 
liabilities or obligations not disclosed in the SEC Documents, other than 
those incurred in the ordinary course of the Company's business since 
March 31, 1995 and which, individually or in the aggregate, do not or would 
not have a Material Adverse Effect on the Company.

                 (i)  NO UNDISCLOSED EVENTS OR CIRCUMSTANCES.  No event or 
circumstance has occurred or exists with respect to the Company or its 
business, properties, prospects, operations or financial condition, which, 
under applicable law, rule or regulation, requires public disclosure or 
announcement by the Company but which has not been so publicly announced or 
disclosed.

            Section 2.2  REPRESENTATIONS AND WARRANTIES OF THE INVESTOR. 
The Investor hereby makes the following representations and warranties 
to the Company:

                 (a)  AUTHORIZATION; ENFORCEMENT.  (i)  The Investor has the 
requisite power and authority to enter into and perform this Agreement and to 
purchase the Shares being sold hereunder, (ii) the execution and delivery of 
this Agreement by the Investor and the consummation by it of the transactions 
contemplated hereby have been duly authorized by all necessary corporate 
action, and no further consent or authorization of the Investor or its Board 
of Directors, stockholders, or partners, as the case may be, is required, 
(iii) this Agreement has been duly authorized, executed and delivered by the 
Investor, and (iv) this Agreement constitutes a valid and binding obligation 
of the Investor enforceable against the Investor in accordance with its 
terms, except as enforceability may be limited by applicable bankruptcy, 
insolvency, reorganization, moratorium, liquidation or similar laws relating 
to, or affecting generally the enforcement of, creditors' rights and 
remedies or by other equitable principles of general application.

                 (b)  NO CONFLICTS.  The execution, delivery and 
performance of this Agreement and the consummation by the Investor of the 
transactions contemplated hereby or relating hereto do not and will not 
(i) result in a violation of the Investor's charter documents or By-Laws or 
(ii) conflict with, or constitute a default (or an event which with notice 
or lapse of time or both would become a default) under, or give to others 
any rights of termination, amendment, acceleration or cancellation of any 
agreement, indenture or instrument to which the Investor is a party, or 
result in a violation of any law, rule, or regulation, or any order, 
judgment or decree of any court or governmental agency applicable to the 
Investor or its properties (except for such conflicts, defaults and 
violations as would not, individually or in the aggregate have a Material 
Adverse Effect on the Investor).  The businesses of the Investor are not 
being conducted in violation of any law, ordinance or regulation of any 
governmental entity, except for possible violations which either singly or 
in the aggregate do not have a Material Adverse Effect.  The Investor is 
not required to obtain any consent, authorization or order of, or make any 
filing or registration with, any court or governmental agency in 

                                  -10-
<PAGE>

order for it to execute, deliver or perform any of its obligations under 
this Agreement or purchase the Shares or the Additional Shares in accordance 
with the terms hereof; provided that for purposes of the representation made 
in this sentence, the Investor is assuming and relying upon the accuracy of 
the relevant representations and agreements of the Company herein.

                 (c)  OWNERSHIP. The Investor is duly organized and validly 
existing under the laws of the place hereinabove provided and is not a U.S. 
Person as defined within Regulation S under the Securities Act and is not 
purchasing the Shares for the account or benefit of a U.S. Person.  On the 
date hereof and on the Closing Date, the Investor is and will be, as the
case may be, located outside of the United States.  The Investor has such 
knowledge and experience in financial and business matters that it is 
capable of evaluating the merits and risks of the investment contemplated 
by this Agreement.  The Investor has been afforded, to the satisfaction of 
the Investor, the opportunity to review the SEC Documents and obtain such 
additional publicly available information concerning the Company and its 
business, and to ask such questions and receive such answers (based upon 
publicly available information), as the Investor deems necessary to make an 
informed investment decision.

                 (d)  INVESTMENT REPRESENTATION:  The Investor is purchasing 
the Shares and, if any, the Additional Shares for investment purposes and 
not with a view towards distribution.  Investor has no present intention to 
sell the Shares or the Additional Shares and the Investor has no present 
arrangement (whether or not legally binding) at any time to sell the Shares 
or the Additional Shares to or through any person or entity; provided, 
however, except as provided in subsection (g) below, that by making the 
representations herein, the Investor does not agree to hold the Shares or 
the Additional Shares for any minimum or other specific term and reserves 
the right to dispose of the Shares or the Additional Shares at any time in 
accordance with Federal securities laws applicable to such disposition.

                 (e)  ACCREDITED INVESTOR:  The Investor is an accredited 
investor as defined in Regulation Section 230.501 promulgated under the Act.

                 (f)  RULE 144.  The Investor understands that the Shares 
and any Additional Shares must be held indefinitely unless such Shares or 
Additional Shares are subsequently registered under the Act or an exemption 
from registration is available.  The Investor has been advised or is aware 
of the provisions of Rule 144 promulgated under the Act.

                 (g)  Notwithstanding the foregoing, the Investor shall not 
sell (including a short sale), transfer or otherwise dispose of the shares, 
or any Additional Shares issued to such Investor, at any time during the 105 
day period following the Closing.  Notwithstanding the foregoing, during the 
Valuation Period Investor will only transfer or otherwise dispose of its 
shares in accordance with the representations contained in EXHIBIT C.


                               ARTICLE III

                                Covenants
                                ---------

            Section 3.1  REGULATION S

                 (a)  Notwithstanding any of the foregoing, the Company 
acknowledges and agrees that in the event that a registration statement 
covering all of the Registrable Securities shall not have become effective 
within 105 days of the Closing Date, legend described in Article V herein 
shall 

                                  -11-
<PAGE>
be removed on the 106th day following the Closing, in accordance with 
Article V herein, it being acknowledged by the Company that, in such event, 
the Investor shall be free to transfer, sell, pledge, or otherwise 
hypothecate the Shares and the Additional Shares issued pursuant to this 
Agreement in accordance with (a) Regulation S under the Act and (b) the 
terms and conditions described in the letter attached hereto as EXHIBIT C.

                 (b)  The Company acknowledges and agrees that, in the 
event the Investor sells, transfers, pledges or otherwise hypothecates the 
Shares or Additional Shares in accordance with Section 3.1(a) herein, for 
purposes of clarifying and specifying the applicable Restricted Period under 
Regulation S, the Investor intends to observe as the Restricted Period (as 
defined in Regulation S) for the Shares being delivered at the Closing the 
period of 40 days commencing upon the Closing Date and ending 40 days 
thereafter, and to observe as the Restricted Period applicable to the 
Additional Shares, if any, the period of 40 days commencing upon the date 
upon which the same are delivered to the Investor hereunder.

                 Neither the Company nor any of its affiliates has engaged 
or will engage in any "directed selling efforts" (as such term is defined 
under Regulation S) with respect to the Shares or the Additional Shares, and 
the Company and its affiliates have complied and will comply with the 
"offering restrictions" requirements of Regulation S.

                 (c)  In the event the Investor sells, transfers or 
otherwise disposes of the Shares or the Additional Shares in accordance with 
Section 3.1(a) herein, the Investor covenants and agrees that such sale, 
transfer or other disposition will be made in compliance with the terms of 
Regulation S under the Act, as in effect at that time, including (i) that 
the Shares and the Additional Shares will not be offered or sold within the 
United States or to, or for the account or benefit of, any "U.S. person" (as 
such term is defined in Rule 902 (o) promulgated under the Act) except in 
accordance with the provisions of Rule 903 or Rule 904 of Regulation S under 
the Securities Act, pursuant to registration under the Act, or pursuant to 
an exemption from the registration requirements of the Act and (ii) that 
neither it, its affiliates, nor persons acting on their behalf, have engaged 
or will engage in "directed selling efforts" (as such term is defined by 
Regulation S) with respect to the Shares or the Additional Shares and that 
each of them has complied and will comply with the "offering restrictions" 
requirements of Regulation S.


            Section 3.2  SECURITIES COMPLIANCE.

                 (a)  The Company shall notify the SEC and Nasdaq, in 
accordance with its requirements, of the transactions contemplated by this 
Agreement, and shall take all other necessary action and proceedings as may 
be required and permitted by applicable law, rule and regulation, including, 
without limitation, the filing of a Form D with the SEC, for the legal and 
valid issuance of the Shares and the Additional Shares to the Investor.

                 (b)  The Investor understands that the Shares and, if any, 
the Additional Shares, are being offered and sold to it in reliance on a 
transactional exemption from the registration 

                                -12-
<PAGE>
requirements of Federal and state securities laws and that the Company is 
relying upon the truth and accuracy of the representations, warranties, 
agreements, acknowledgments and understandings of such Investor set forth 
herein in order to determine the applicability of such exemptions and the 
suitability of such Investor to acquire the Shares.

            Section 3.3  CORPORATE.  (a) From the date hereof through the 
end of the Valuation Period the Company shall not (i) amend its Certificate 
or By-Laws so as to adversely affect any rights of the Investor; (ii) split, 
combine or reclassify its outstanding capital stock; (iii) declare or set 
aside or pay any dividend or other distribution with respect to the Company's 
outstanding Common Stock; (iv) issue or sell, directly or indirectly, Shares 
of the Company's Common Stock in a manner or upon terms as could reasonably 
be expected to affect the market for the Common Stock materially and 
adversely; or (v) enter into any agreement with respect to the foregoing; 
and (vi) the Company shall at all times reserve and keep available, solely 
for issuance and delivery as Shares or Additional Shares hereunder, such 
shares of Common Stock as shall from time to time be issuable or reasonably 
be expected to be issuable as Shares or Additional Shares hereunder provided, 
however, that the number of shares so reserved shall at all times be at least 
300% of the Share Number.

                 (b)  The Company will cause its Common Stock to continue to 
be registered under Sections 12(b) or 12(g) of the Exchange Act, will comply 
in all respects with its reporting and filing obligations under said act, 
will comply with all requirements related to any registration statement filed 
pursuant to Section 1.5 herein, and will not take any action or file any 
document (whether or not permitted by said Act or the rules thereunder) to 
terminate or suspend such registration or to terminate or suspend its 
reporting and filing obligations under said act, except as permitted herein.  
The Company will take all action necessary to continue the listing or trading 
of its Common Stock on the Nasdaq National Market and will comply in all 
respects with the Company's reporting, filing and other obligations under 
the bylaws or rules of the NASD and Nasdaq.


                               ARTICLE IV

                               Conditions
                               ----------

            Section 4.1  CONDITIONS PRECEDENT TO THE OBLIGATION OF THE 
COMPANY TO SELL THE SHARES. The obligation hereunder of the Company to 
issue and/or sell the Shares or the Additional Shares to the Investor is 
further subject to the satisfaction, at or before the respective issuance 
and deliveries thereof, of each of the following conditions set forth below.  
These conditions are for the Company's sole benefit and may be waived by the 
Company at any time in its sole discretion.

                 (a)  ACCURACY OF THE INVESTOR REPRESENTATIONS AND 
WARRANTIES.  The representations and warranties of the Investor shall be true 
and correct in all material respects as of the date when made and as of the 
date of such issuance and delivery as though made at that time.

                 (b)  PERFORMANCE BY THE INVESTOR.  The Investor shall 
have performed, satisfied and complied in all material respects with all 
covenants, agreements and conditions required by this Agreement to be 
performed, satisfied or complied with by the Investor at or prior to 
such date.

                 (c)  NO INJUNCTION.  No statute, rule, regulation, 
executive order, decree, ruling or injunction shall have been enacted, 
entered, promulgated or endorsed by any court or governmental authority 
of competent jurisdiction which  prohibits the consummation of any of 
the transactions contemplated by this Agreement.

                                  -13-
<PAGE>

            Section 4.2  CONDITIONS PRECEDENT TO THE OBLIGATION OF THE 
INVESTOR TO PURCHASE THE SHARES.  The obligation of the Investor hereunder 
to acquire and pay for the Shares is subject to the satisfaction, at or 
before the Closing of each of the following conditions set forth below.  
These conditions are for the Investor's sole benefit and may be waived by 
the Investor at any time in its sole discretion.

                 (a)  ACCURACY OF THE COMPANY'S REPRESENTATIONS AND 
WARRANTIES.  The representations and warranties of the Company shall be true 
and correct in all material respects as of the date when made and as of the 
Closing Date as though made at that time (except for representations and 
warranties that speak as of a particular date).

                 (b)  PERFORMANCE BY THE COMPANY.  The Company shall 
have performed, satisfied and complied in all material respects with all 
covenants, agreements and conditions required by this Agreement to be 
performed, satisfied or complied with by the Company at or prior to the 
Closing.

                 (c)  NASDAQ.  From the date hereof to the Closing Date, 
as to the Shares to be issued and delivered on the Closing Date, trading 
in the Company's Common Stock shall not have been suspended by the SEC 
or the Nasdaq National Market (except for any suspension of trading of 
limited duration agreed to between the Company and the Nasdaq National 
Market solely to permit dissemination of material information regarding 
the Company), and trading in securities generally as reported by Nasdaq 
shall not have been suspended or limited or minimum prices shall not 
have been established on securities whose trades are reported by Nasdaq.  
Notwithstanding the foregoing sentence, in the event that at any point 
on or prior to the first day of the Valuation Period trading in the 
Common Stock is suspended by the SEC or the Nasdaq National Market, 
(i) calculation of the Average Stock Price shall be suspended for such 
period of time as trading in the Common Stock is suspended and (ii) the 
Valuation Period shall be reset so that such Valuation Period shall 
begin on the 90th calendar day following the Closing Date and shall end 
on the 45th calendar day thereafter on which quotations for the 
Company's Common Stock on the Nasdaq National Market are available.  In 
the event that the Company's Common Stock is delisted from the Nasdaq 
National Market at any time during the Valuation Period or in the event 
that trading in the Common Stock is suspended for a period of more than 
thirty (30) days subsequent to the commencement of the Valuation Period, 
(iii) the Valuation Period will be deemed to have concluded on the date 
on which the Common Stock was delisted or such trading was suspended, 
(iv) the Average Stock Price shall be calculated based on the number of 
days in such shortened Valuation Period, and (v) the Investor shall 
receive any Additional Shares owed to it pursuant to Section 1.3(c) 
herein within five (5) business days of the conclusion of the shortened 
Valuation Period.  In no event shall the Investor be required to deliver 
any shares for cancellation pursuant to Section 1.3(d) herein if the 
Common Stock is delisted from the Nasdaq National Market or if trading 
in the Common Stock is suspended for more than thirty (30) days during 
the Valuation Period or prior to the effectiveness of the Company's 
Initial Registration.

                 (d)  NO INJUNCTION.  No statute, rule, regulation, 
executive order, decree, ruling or injunction shall have been enacted, 
entered, promulgated or endorsed by any court or governmental authority 
of competent jurisdiction which prohibits the consummation of any of the 
transactions contemplated by this Agreement.

                                 -14
<PAGE>
                 (e)  OPINION OF COUNSEL, ETC.  At the Closing the 
Investor shall have received an opinion of Brobeck Phleger & Harrison, 
counsel to the Company, in form and substance satisfactory to the 
Investor and its counsel (in substantially the form of EXHIBIT B 
hereto), and such other certificates and documents as the Investor or 
its counsel shall reasonably require incident to the Closing.


                                ARTICLE V

                             Legend on Stock
                             ---------------

            Each certificate representing the Shares issued pursuant to 
Section 1.3 shall be stamped or otherwise imprinted with a legend 
substantially in the following form:

          THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE 
          SECURITIES ACT OF 1933 OR ANY STATE SECURITIES LAWS.  
          THEY MAY NOT BE SOLD OR OFFERED FOR SALE IN THE 
          ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO 
          THE SECURITIES UNDER SAID ACT AND ANY APPLICABLE 
          STATE SECURITIES LAW OR AN APPLICABLE EXEMPTION FROM 
          THE REGISTRATION REQUIREMENTS OF THE ACT.  THIS 
          LEGEND SHALL CEASE TO HAVE ANY FORCE OR EFFECT AND 
          WILL BE REMOVED ON OCTOBER 7, 1995 UNLESS AN OPINION 
          OF COUNSEL TO THE COMPANY, IN FORM AND SUBSTANCE 
          SATISFACTORY TO THE INVESTOR AND ITS COUNSEL, IS 
          DELIVERED TO THE COMPANY'S TRANSFER AGENT ON OR 
          PRIOR TO SUCH DATE STATING THAT REMOVAL OF THIS 
          LEGEND IS NOT PERMITTED UNDER LAW DUE TO A CHANGE IN 
          LAW SUBSEQUENT TO JUNE 23, 1995.

            Notwithstanding the foregoing, this legend shall cease to 
have any force or effect and will be removed on October 7, 1995, unless 
an opinion of counsel to the Company, in form and substance satisfactory 
to the Investor and its counsel, is delivered to the Company's transfer 
agent, on or prior to such date stating that removal of the legend is 
not permitted under law due to a change in law subsequent to the date 
hereof.
	
            No certificate representing Additional Shares, if any, 
required to be issued pursuant to this Agreement will bear a restrictive 
legend unless an opinion of the Company's counsel, in form and substance 
satisfactory to the Investor, has been issued to the Company's transfer 
agent on or prior to the issuance of such Additional Shares stating that 
such a legend is required by law due to a change in law subsequent to 
the date hereof.

                               ARTICLE VI

                               Termination
                               -----------

            Section 6.1  TERMINATION BY MUTUAL CONSENT.  This Agreement 
may be terminated at any time prior to the Closing by the mutual consent 
of the Company and the Investor, by action of their respective Boards of 
Directors or other governing body.

                                  -15-
<PAGE>
            Section 6.2  OTHER TERMINATION.  This Agreement may be 
terminated by action of the Board of Directors or other governing body 
of the Investor or the Company at any time after June 23, 1995 if the 
Closing shall not have been consummated by June 23, 1995.

            Section 6.3  AUTOMATIC TERMINATION.  This Agreement shall 
automatically terminate without any further action of either party 
hereto if the Closing shall not have occurred by June 23, 1995.


                              ARTICLE VII

                             Miscellaneous
                             -------------

            Section 7.1  FEES AND EXPENSES.  Each party shall pay the 
fees and expenses of its advisers, counsel, accountants and other 
experts, if any, and all other expenses incurred by such party incident 
to the negotiation, preparation, execution, delivery and performance of 
this Agreement, provided that the Company shall pay, at the Closing, all 
attorneys' fees and expenses incurred by the Investor and Cappello 
Capital Corp., up to a maximum of $6,666, in connection with the 
preparation, negotiation, execution and delivery of this Agreement and 
the transactions contemplated hereunder.  Without limiting the 
generality of the foregoing, The Kriegsman Group shall be entitled to a 
finders fee pursuant to a separate agreement with respect thereto 
between such finder and the Company, and the Company shall be solely 
responsible for the full payment thereof and shall indemnify and hold 
harmless the Investor from and against all loss, cost, damage or expense 
arising therefrom.  The Company shall pay all stamp and other taxes and 
duties levied in connection with the issuance of the Shares or the 
Additional Shares pursuant hereto.

            Section 7.2  SPECIFIC ENFORCEMENT; CONSENT TO JURISDICTION.

                 (a)  The Company and the Investor acknowledge and agree 
that irreparable damage would occur in the event that any of the 
provisions of this Agreement were not performed in accordance with their 
specific terms or were otherwise breached.  It is accordingly agreed 
that the parties shall be entitled to an injunction or injunctions to 
prevent or cure breaches of the provisions of this Agreement and to 
enforce specifically the terms and provisions hereof, this being in 
addition to any other remedy to which either of them may be entitled by 
law or equity.

                 (b)  Each of the Company and the Investor (i) hereby 
irrevocably submits to the exclusive jurisdiction of the United States 
District Court and other courts of the United States sitting in New York 
for the purposes of any suit, action or proceeding arising out of or 
relating to this  Agreement and (ii) hereby waives, and agrees not to 
assert in any such suit, action or proceeding, any claim that it is not 
personally subject to the jurisdiction of such court, that the suit, 
action or proceeding is brought in an inconvenient forum or that the 
venue of the suit, action or proceeding is improper.  Each of the 
Company and the Investor consents to process being served in any such 
suit, action or proceeding by mailing a copy thereof to such party at 
the address in effect for notices to it under this Agreement and agrees 
that such service shall constitute good and sufficient service of 
process and notice thereof.  Nothing in this paragraph shall affect or 
limit any right to serve process in any other manner permitted by law.

            Section 7.3  ENTIRE AGREEMENT; AMENDMENTS.  This Agreement 
contains the entire understanding of the parties with respect to the 
matters covered hereby and thereby and, except as specifically set forth 
herein, neither the Company nor the Investor makes any representation, 

                                 -16-
<PAGE>
warranty, covenant or undertaking with respect to such matters.  No 
provision of this Agreement may be waived or amended other than by a 
written instrument signed by the party against whom enforcement of any 
such amendment or waiver is sought.

            Section 7.4  NOTICES.  Any notice or other communication 
required or permitted to be given hereunder shall be in writing and 
shall be effective (a) upon hand delivery or delivery by telex (with 
correct answer back received), telecopy or facsimile at the address or 
number designated below (if delivered on a business day during normal 
business hours where such notice is to be received), or the first 
business day following such delivery (if delivered other than on a 
business day during normal business hours where such notice is to be 
received) or (b) on the second business day following the date of 
mailing by express courier service, fully prepaid, addressed to such 
address, or upon actual receipt of such mailing, whichever shall first 
occur.  The addresses for such communications shall be:

            to the Company:

                         Advanced Tissue Sciences, Inc.
                         10933 North Torrey Pines Road
                         La Jolla, California 92037
                         Attn:  Chief Executive Officer

            with copies to:

                         Brobeck Phleger & Harrison
                         4675 MacArthur Court
                         Suite 1000
                         Newport Beach, California 92660
                         Attn:  Laura M. Brower, Esq.

            to the Investor:

                         S. P. Investors International S.A.
                         c/o Bank of Bermuda Ltd.
                         Corp. Trust Services Department
                         Attn:  Stewart Bent
                         129 Front St.
                         Hamilton 5-31
                         Bermuda

            with copies to:

                         The Palladin Group, L.P.
                         40th West 5th Street
                         Suite 1500
                         New York, New York 10019
                         Attn:  Jeffrey Devers

Either party hereto may from time to time change its address for notices 
under this Section 7.4 by giving at least 10 days' written notice of 
such changed address to the other party hereto.

                                 -17-
<PAGE>
            Section 7.5  WAIVERS.  No waiver by either party of any 
default with respect to any provision, condition or requirement of this 
Agreement shall be deemed to be a continuing waiver in the future or a 
waiver of any other provision, condition or requirement hereof, nor 
shall any delay or omission of either party to exercise any right 
hereunder in any manner impair the exercise of any such right accruing 
to it thereafter.

            Section 7.6  HEADINGS.  The headings herein are for 
convenience only, do not constitute a part of this Agreement  and shall 
not be deemed to limit or affect any of the provisions hereof.

            Section 7.7  SUCCESSORS AND ASSIGNS.  This Agreement shall 
be binding upon and inure to the benefit of the parties and their 
successors and assigns.  The parties hereto may amend this Agreement 
without notice to or the consent of any third party.  Neither the 
Company nor the Investor shall assign this Agreement or any rights or 
obligations hereunder without the prior written consent of the other 
(which consent may be withheld for any reason in the sole discretion of 
the party from whom consent is sought); provided, however, that the 
Company may assign its rights and obligations hereunder to any acquirer 
of substantially all of the assets or a controlling equity interest of 
the Company.  The assignment by a party of this Agreement or any rights 
hereunder shall not affect the obligations of such party under this 
Agreement.

            Section 7.8  NO THIRD PARTY BENEFICIARIES.  This Agreement 
is intended for the benefit of the parties hereto and their respective 
permitted successors and assigns and is not for the benefit of, nor may 
any provision hereof be enforced by, any other person.

            Section 7.9  GOVERNING LAW.  This Agreement shall be 
governed by and construed and enforced in accordance with the internal 
laws of Delaware without regard to the principles of conflict of laws.

            Section 7.10  SURVIVAL. The representations and warranties 
of the Company and the Investor contained in Article II and the 
agreements and covenants set forth in Articles I and III shall survive 
the Closing.

            Section 7.11  EXECUTION.  This Agreement may be executed in 
two or more counterparts, all of which shall be considered one and the 
same agreement and shall become effective when counterparts have been 
signed by each party and delivered to the other party, it being 
understood that both parties need not sign the same counterpart.  In the 
event any signature is delivered by facsimile transmission, the party 
using such means of delivery shall cause four additional executed 
signature pages to be physically delivered to the other party within 
five days of the execution and delivery hereof.

            Section 7.12  PUBLICITY.  The Company and the Investor shall 
consult and cooperate with each other in issuing any press releases or 
otherwise making public statements with respect to the transactions 
contemplated hereby, provided the foregoing shall not interfere with the 
legal obligations of either party with respect to public disclosure; and 
provided further, that neither the Company nor the Investor shall be 
required to consult with the other if any such press release or public 
statement does not specifically name the other.

              [Remainder of page intentionally left blank.]

                                  -18-
<PAGE>

            IN WITNESS WHEREOF, the parties hereto have caused this 
Agreement to be duly executed by their respective authorized officers as 
of the date hereof.

                                    ADVANCED TISSUE SCIENCES, INC.


                                    By:  /s/ Arthur J. Benvenuto
                                          ------------------------------
                                          Name: Arthur J. Benvenuto
                                          Its: Chairman, President & CEO

                                    S. P. INVESTORS INTERNATIONAL S.A.

                                    By:  The Palladin Group, L.P., its 
                                            investment manager

                                         By: Palladin Capital Management, LLC
                                             Its General Partner


                                             By:  /s/ Jeffrey Devers
                                                  ----------------------
                                                  Title:  President


                                     -19-
<PAGE>






                                                                EXHIBIT A

                            CAPITALIZATION SUMMARY


The following table reconciles the Company's outstanding Common Stock and 
options and warrants as reported in the Company's Quarterly Report on 
Form 10-Q as of March 31, 1995 to June 13, 1995.

                                           Common         Options and
                                            Stock          Warrants
                                          Outstanding     Outstanding
                                         -------------   -------------

   Outstanding per Form 10-Q             30,570,993       4,186,957
   Options and warrants exercised           561,200        (561,200)
   Options and warrants granted                   -         125,000
   Options and warrants canceled                  -        (139,209)
                                         ----------       ---------

   Outstanding as of June 13, 1995       31,132,193       3,611,548
                                         ==========       =========


As of June 13, 1995, the Company had 1,900,462 remaining available for grant 
under its 1992 Stock Option/Stock Issuance Plan.

The Company will issue warrants to purchase 135,000 shares of Common Stock 
to the placement agents involved in this transaction on the Closing Date at 
an initial exercise price of $6.86 per share.

On January 5, 1995, the Company's Board of Directors (the "Board") adopted a 
Shareholder Rights Plan (the "Rights Plan").  Pursuant to the Rights Plan, 
the Board declared a dividend of one preferred share purchase right (the 
"Right") for each share of Common Stock outstanding on January 20, 1995.  
Each Right entitles the registered holder to purchase from the Company 
one-hundredth of a share of Series A Junior Participating Preferred Stock 
at an exercise price of $55 per one-hundredth share, subject to adjustment.

<PAGE>


                                                                 EXHIBIT B




                                      June 23, 1995

S.P. Investors International S.A.
Steinhardt Overseas Fund Ltd.
c/o Bank of Bermuda Ltd.
Corporate Trust Services Department
129 Front Street
Hamilton 5-31
Bermuda
Attention:  Stewart Bent

Gershon Partners L.P.
Royal Trust Bank Cayman Ltd.
2nd Floor
Royal Bank of Canada Building
Cardinal Avenue
Grand Cayman, Cayman Island
Attention:  Frank Boers

            Re:  Advanced Tissue Sciences, Inc.

Ladies and Gentlemen:

            We have acted as counsel for Advanced Tissue Sciences, Inc., a 
Delaware corporation (the "Company"), in connection with the issuance and 
sale of shares of its Common Stock pursuant to those certain Investment 
Agreements dated as of June 23, 1995 (the "Purchase Agreement") by and 
between the Company and each of S.P. Investors International S.A., 
Steinhardt Overseas Fund Ltd. and Gershon Partners L.P. (collectively the 
"Purchasers").  This opinion is being rendered to you pursuant to Section 
4.2(e) of the Purchase Agreement.  Capitalized terms used herein and not
otherwise defined herein shall have the meanings given to such terms in the 
Purchase Agreement.  

            In connection with the opinions expressed herein we have made 
such examination of matters of law and of fact as we considered appropriate 
or advisable for purposes hereof.  As to matters of fact material to the 
opinions expressed herein, we have relied upon the representations and 
warranties as to factual matters contained in and made by the Company 
pursuant to the Purchase Agreement and upon certificates and statements of 
government officials and of officers of the Company.  We have also examined 
originals or copies of such corporate documents or records of the Company as
we have considered appropriate for the opinions expressed herein.  We have 
assumed for the purposes of this opinion that the signatures on documents 
and instruments examined by us are authentic, that each document is what it 
purports to be, and that all documents submitted to us as copies conform with 
the originals, which facts we have not independently verified.

<PAGE>
S.P. Investors International S.A.                                  Page 2
Steinhardt Overseas Fund Ltd.
Gershon partners L.P.
Agreement dated June 23, 1995
June 23, 1995

            In rendering this opinion we have also assumed:  (A) that the 
Purchase Agreement has been duly and validly executed and delivered by you 
or on your behalf and constitute valid, binding and enforceable obligations 
upon you; (B) that the representations and warranties made in the Purchase 
Agreement by you are true and correct; (C) that any wire transfers, drafts 
or checks tendered by you will be honored; (D) if you are a corporation or 
other entity, that you have filed any required state franchise, income or
similar taxes; and (E) that there are no extrinsic agreements or 
understandings among the parties to the Purchase Agreement that would 
modify or interpret the terms of the Purchase Agreement or the respective 
rights or obligations of the parties thereunder, other than as set forth on 
Exhibit C thereto.

            As used in this opinion, the expression "we are not aware" or 
the phrase "to our knowledge" means as to matters of fact that, based on 
the actual knowledge of individual attorneys within the firm principally 
responsible for handling current matters for the Company and after an 
examination of documents referred to herein and after inquiries of certain 
officers of the Company, we find no reason to believe that the opinions 
expressed are factually incorrect; but beyond that we have made no factual 
investigation for the purposes of rendering this opinion.  Specifically, 
but without limitation, we have made no inquiries of securities holders or 
employees of the Company.

            This opinion relates solely to the general corporate laws of the 
State of Delaware and the federal law of the United States (except that our 
opinion in paragraphs 5 and 6 below also pertains to the laws of the State 
of California), and we express no opinion with respect to the effect or 
application of any other laws.  Special rulings of authorities administering 
such laws or opinions of other counsel have not been sought or obtained.  

            Based upon our examination of and reliance upon the foregoing 
and subject to the limitations, exceptions, qualifications and assumptions 
set forth below and except as set forth in the Purchase Agreement thereto, 
we are of the opinion that as of the date hereof:

            1.  The Company is a corporation duly organized, validly 
existing and in good standing under the laws of the State of Delaware, and 
the Company has the requisite corporate power and authority to own its 
properties and to conduct its business as presently conducted.

<PAGE>
S.P. Investors International S.A.                                 Page 3
Steinhardt Overseas Fund Ltd.
Gershon Partners L.P.
Agreement dated June 23, 1995
June 23, 1995

            2.  To our knowledge, the Company is duly qualified to do 
business as a foreign corporation and is in good standing in each 
jurisdiction where the ownership or leasing of its properties or the 
conduct of its business requires such qualification, except where the 
failure to so qualify does not have a Material Adverse Effect.  

            3.  The Company has the requisite corporate power and authority 
to execute, deliver and perform the Purchase Agreement.  The Purchase 
Agreement has been duly and validly authorized by the Company, duly 
executed and delivered by an authorized officer of the Company and 
constitutes a legal, valid and binding obligation of the Company, 
enforceable against the Company according to its terms.

            4.  The capitalization of the Company is as stated in the 
Company's Quarterly Report on Form 10-Q for the quarter ended March 31, 
1995, as amended and supplemented by Exhibit A to the Purchase Agreement 
(collectively, the "Supplemented 10-Q").  No shares of Common Stock are 
entitled to preemptive rights, and except as described in the Supplemented 
10-Q, there are no preemptive rights or, to our knowledge, options, 
warrants, conversion privileges or other rights (or agreements for any such 
rights) outstanding to purchase or otherwise obtain from the Company any
of the Company's securities.

            5.  The execution, delivery, performance and compliance with 
the terms of the Purchase Agreement do not violate any provision of any 
federal, California state or Delaware corporate law, rule or regulation 
applicable to the Company, or by which any property or asset of the Company 
is bound or affected, or the Company's Certificate or Bylaws, or conflict 
with, or constitute a default under, or give to others any rights of 
termination, amendment, acceleration or cancellation of, any agreement or 
in the Company is a party and which has been filed as a material agreement 
in the Company's Annual Report on Form 10-K for the year ended 
December 31, 1994. 

            6.  All consents, approvals, permits, orders or authorizations 
of, and all qualifications, registrations, designations, declarations or 
filings with, any federal, California state or Delaware general corporate 
governmental authority on the part of the Company required in connection 
with the execution and delivery of the Purchase Agreement and consummation 
at the Closing of the transactions contemplated by the Purchase Agreement 
have been obtained, and are effective, except the additional listing
application required to be filed with the National Association of Securities
Dealers, Inc. and the registration statement required to

<PAGE>
S.P. Investors International S.A.                                 Page 4
Steinhardt Overseas Fund Ltd.
Gershon Partners L.P.
Agreement dated June 23, 1995
June 23, 1995


be filed with the Securities and Exchange Commission by Section 1.5 of the 
Purchase Agreement, and we are not aware of any proceedings, or threat 
thereof, that question the validity thereof.

            7.  The Shares have been duly authorized and, when issued and 
delivered to the Purchasers against payment therefor in accordance with the 
terms of the Purchase Agreement, will be validly issued, fully paid and 
non-assessable.

            8.  The Additional Shares have been authorized and reserved for 
issuance pursuant to the terms of the Purchase Agreement, and when issued 
and delivered to the Purchasers in accordance with the terms of the Purchase 
Agreement, will be validly issued, fully paid and non-assessable.

            9.  We are not aware of any action, proceeding or governmental 
investigation pending or threatened against the Company which questions the 
validity, or which affects the enforceability, of the Purchase Agreement or 
the right of the Company to enter into such Purchase Agreement or which 
would, if decided adversely to the Company, have a Material Adverse Effect.

            Our opinions expressed above are specifically subject to the 
following limitations, exceptions, qualifications and assumptions:

            (A)  For purposes of our opinions in paragraphs 5 and 6 above, 
we are rendering no opinion as to the applicability of, or the Company's 
compliance or non-compliance with, any federal, state or foreign securities 
laws as they may relate to the transactions described in the Purchase 
Agreement, the execution, delivery and performance of the Purchase Agreement 
by the Company and the consummation by the Company of the transactions 
contemplated thereby.

            (B)  The effect of bankruptcy, insolvency, reorganization, 
moratorium and other similar laws relating to or affecting the relief of 
debtors or the rights and remedies of creditors generally, including without 
limitation the effect of statutory or other law regarding fraudulent 
conveyances and preferential transfers.

            (C)  We express no opinion as to the Company's compliance or 
noncompliance with applicable federal or state antifraud or antitrust 
statutes, laws, rules and regulations.

            (D)  Limitations imposed by general equitable principles upon 
the specific enforceability of any of the remedies, covenants 

<PAGE>
S.P. Investors International S.A.                                 Page 5
Steinhardt Overseas Fund Ltd.
Gershon Partners L.P.
Agreement dated June 23, 1995
June 23, 1995


or other provisions of any applicable agreement and upon the availability 
of injunctive relief or other equitable remedies, regardless of whether 
enforcement of any such agreement is considered a proceeding in equity or 
at law.

            (E)  The unenforceability under certain circumstances of 
provisions, indemnifying a party against, or requiring contributions toward, 
that party's liability for its own wrongful or negligent acts, or where 
indemnification or contribution is contrary to public policy.  In this 
regard, we advise you that in the opinion of the Securities and Exchange 
Commission indemnification of directors, officers and controlling persons 
of an issuer against liabilities arising under the Securities Act of 1933, 
as amended, is against public policy and is therefore unenforceable.

            This opinion is rendered as of the date first written above 
solely for your benefit in connection with the Purchase Agreement and may 
not be delivered to, quoted or relied upon by any person other than you, or 
for any other purpose, without our prior written consent.  Our opinion is 
expressly limited to the matters set forth above and we render no opinion, 
whether by implication or otherwise, as to any other matters relating to 
the Company.  We assume no obligation to advise you of facts, circumstances,
events or developments which hereafter may be brought to our attention and
which may alter, affect or modify the opinions expressed herein.

                                     Very truly yours,



                                     BROBECK, PHLEGER & HARRISON          

<PAGE>


                                                             EXHIBIT C



                                          June 23, 1995
Advanced Tissue Sciences, Inc.
10933 North Torrey Pines Road
La Jolla, California 92037
Attention:  Arthur Benvenuto

Re:     Regulation S Offering
        ---------------------

Ladies and Gentlemen:

Reference is made to the Investment Agreement of even date and delivery 
herewith (the "Agreement") between the undersigned ("Investor") and Advanced 
Tissue Sciences, Inc.  Capitalized terms contained in this letter shall 
have the same meaning ascribed to them in the Agreement.

In addition to the representations and covenants of the Investor contained 
in the Agreement, Investor further covenants and agrees as follows:

     1.     In the event the Investor engages in short sales transactions 
            or other hedging activities during the period from 105 days 
            following the Closing through 135 days following the Closing 
            which involve, among other things, sales of Common Stock of the 
            Company, Investor will, to the extent within its reasonable 
            control, conduct such activities so as not to complete or 
            effect any such sale on any trading day during such period 
            at a price which is lower than the lowest sale effected on 
            such day by persons other than the Investor;

     2.     Investor covenants that it will comply with all applicable 
            laws, rules and regulations regarding the foregoing activities 
            and/or the financing of the Shares and Additional Shares 
            including, if applicable, compliance with Regulation S.


                        [Signatures on next page.]

                                  -1-
<PAGE>

                                        Very truly yours,


                                        S. P. INVESTORS INTERNATIONAL S.A.

                                        By:  The Palladin Group, L.P.,
                                             its investment manager

                                        By:  Palladin Capital Management, LLC
                                             Its General Partner


                                        By:  /s/ Jeffrey Devers
                                            -------------------------------
                                            Title:  President


<PAGE>
                                                                Exhibit 4.2

                          INVESTMENT AGREEMENT


                                 Between



                     ADVANCED TISSUE SCIENCES, INC.



                                   And


                      STEINHARDT OVERSEAS FUND LTD.




                       Dated as of June 23, 1995







     THE SECURITIES TO BE PURCHASED AND SOLD PURSUANT TO 
THIS INVESTMENT AGREEMENT HAVE NOT BEEN REGISTERED UNDER THE 
SECURITIES ACT OF 1933, AS AMENDED, (THE "ACT") OR ANY STATE 
SECURITIES LAWS.  THEY MAY NOT BE OFFERED OR SOLD IN THE 
ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THE 
SECURITIES UNDER SAID ACT AND ANY APPLICABLE STATE 
SECURITIES LAW OR AN APPLICABLE EXEMPTION FROM THE 
REGISTRATION REQUIREMENTS OF THE ACT.

<PAGE>

      INVESTMENT AGREEMENT dated as of June 23, 1995 between Steinhardt 
Overseas Fund Ltd., ( the "Investor") and Advanced Tissue Sciences, 
Inc., a corporation organized and existing under the laws of the State 
of Delaware (the "Company").

            WHEREAS, the parties desire that the Investor become an 
equity investor in the Company by purchasing an aggregate of 500,000 
shares of the Company's Common Stock, par value $.01 per share (the 
"Common Stock").

            NOW, THEREFORE, the parties hereto agree as follows:


                                ARTICLE I

                    Purchase and Sale of Common Stock
                    ---------------------------------

            Section 1.1  PURCHASE AND SALE OF COMMON STOCK.  Upon the 
terms and conditions set forth herein, the Company shall issue and sell 
to the Investor, and the Investor shall purchase from the Company, 
500,000 shares of the Company's Common Stock (the "Shares").

            Section 1.2  PURCHASE PRICE.  The aggregate purchase price 
for the Shares (the "Purchase Price") shall equal $3,430,000 payable in 
cash by wire transfer or cashier's check in immediately available funds.

            Section 1.3  SHARE NUMBER; VALUATION PERIOD.

                 (a)  The number of Shares that the Company shall be 
obligated to issue and sell and the Investor shall be obligated to 
purchase hereunder, in the aggregate, is referred to herein as the 
"Share Number."  Subject to adjustment as provided in Sections 1.3(c), 
1.3(d) and 1.3(e), the Share Number shall initially be 500,000.

                 (b)  The "Valuation Period" shall be a 45 calendar day 
period commencing on and including the first business day which is 90 
calendar days after the Closing Date (as defined herein) as the same may 
be modified pursuant to Section 4.2(c) hereof.

                 (c)  Notwithstanding Section 1.3(a) above, and except 
as hereinafter provided, if the Average Share Price (hereinafter 
defined) during the Valuation Period is less than $7.75, then the 
Company shall deliver to the Investor, at no additional cost to the 
Investor, and in addition to the initial Share Number, the number of 
shares of Common Stock that is obtained by subtracting (x) 500,000 from 
(y) the quotient obtained by dividing the Purchase Price by 88.5% of the 
Average Share Price (rounded to the nearest whole number) (together with 
any additional shares issued pursuant to Section 1.3(e) herein, the 
"Additional Shares").

                 (d)  Notwithstanding Section 1.3(a) above, and except 
as hereinafter provided, if the Average Share Price during the Valuation 
Period is greater than $7.75, the Investor shall pay to the Company the 
dollar amount by which (x) the product of 88.5% of the Average Share 
Price and the Share Number exceeds (y) the product of $6.86 and the 
Share Number.

                 (e)  Notwithstanding Section 1.3(c) above, in the event 
that the Company, on or prior to 135 days from the Closing Date, issues 
or sells any shares of its Common Stock or any of its securities which 
are convertible into or exchangeable for its Common Stock or any 
warrants or 
<PAGE>

other rights to subscribe for or to purchase or any options for the purchase 
of, its Common Stock (other than shares or options issued pursuant to the 
Company's option plans or shares issued upon exercise of options, warrants 
or rights outstanding on the Closing Date or as provided on EXHIBIT A 
hereto), at a purchase price which is less than $6.86 per share (the 
"Subsequent Sale Price"), then the Company shall deliver to the Investor, 
at no additional cost to the Investor, and in addition to the Share Number, 
the number of shares of Common Stock that is obtained by subtracting 
(x) 500,000 from (y) the quotient obtained by dividing the Purchase Price 
by the Subsequent Sale Price (rounded to the nearest whole number).

                 Notwithstanding any of the foregoing, the number of 
Additional Shares issuable hereunder shall be the greater of the number 
of Additional Shares issuable pursuant to Section 1.3(c) herein and the 
number of Additional Shares issuable pursuant to Section 1.3(e) herein, 
if any.

                 (f)  For purposes hereof, the Average Share Price shall 
mean the average of the closing trading prices of the Company's Common 
Stock on the Nasdaq National Market, as reported by the Nasdaq National 
Market for each trading day during the Valuation Period.

            Section 1.4  THE CLOSING.

                 (a)  The closing of the purchase and sale of the Shares 
(the "Closing"), shall take place (a) at the offices of the Investor, at 
10:00 a.m., local time on the later of the following:  (i) June 23, 
1995, and (ii) the date on which the last to be fulfilled or waived of 
the conditions set forth in Article IV hereof and applicable to the 
Closing shall be fulfilled or waived in accordance herewith, or (b) at 
such other time and place and/or on such other date as the Investor and 
the Company may agree.  The date on which the Closing occurs is referred 
to herein as the "Closing Date."

                 (b)  (i)  On the Closing Date, the Company shall deliver 
to the Investor certificates representing the Share Number to be issued 
and sold to the Investor on such date and registered in the name of the 
Investor or deposit such Share Number into the accounts designated by 
the Investor and (ii) on the Closing Date, the Investor shall deliver to 
the Company the Purchase Price by cashier's check or wire transfer in 
immediately available funds to such account as shall be designated in 
writing by the Company.  In addition, each of the Company and the 
Investor shall deliver all documents, instruments and writings required 
to be delivered by either of them pursuant to this Agreement at or prior 
to the Closing.

            Section 1.5.  COVENANT TO REGISTER.  For purposes of this 
Section 1.5, the following definitions shall apply:

                 (a)  (i)  The terms "register," "registered," and 
"registration" refer to a registration under the Act effected by 
preparing and filing a registration statement or similar document in 
compliance with the Act, and the declaration or ordering of 
effectiveness of such registration statement, document or amendment 
thereto.

                     (ii)  The term "Registrable Securities" means the 
Shares and any Additional Shares issued pursuant to Section 1.3 hereof 
and any securities of the Company or securities of any successor 
corporation issued as, or issuable upon the conversion or exercise of 
any warrant, right or other security that is issued as a dividend or 
other distribution with respect to, or in 

                                  -3-
<PAGE>

exchange for, or in replacement of, the Shares and any Additional Shares 
issued pursuant to Section 1.3 hereof.

                 (b)  (i)  The Company shall, as expeditiously as 
possible following the Closing, file a registration statement on Form S-
3 or an equivalent thereof promptly after the Closing Date, covering all 
the Registrable Securities, and shall use its best efforts to cause such 
registration statement to become effective within 105 days of the 
Closing Date (the "Initial Registration").  In the event such 
registration is not so declared effective, the holder of the Registrable 
Securities shall have the right to require by notice in writing that the 
Company register all or any part of the Registrable Securities held by 
such holder (a "Demand Registration") and the Company shall thereupon 
effect such registration in accordance herewith.  The parties agree that 
if the holder of Registrable Securities demands registration of less 
than all of the Registrable Securities, the Company, at its option, may 
nevertheless file a registration statement covering all of the 
Registrable Securities.  If such registration statement is declared 
effective with respect to all Registrable Securities the demand 
registration rights granted pursuant to this Section 1.5 (b) (i) shall 
cease.  If such registration statement is not declared effective with 
respect to all Registrable Securities the demand registration rights 
described herein shall remain in effect until all Registrable Securities 
have been registered under the Act.

                     (ii)  The Company shall not be obligated to effect 
Demand Registration (i) if all of the Registrable Securities held by the 
holder of Registrable Securities which are intended to be covered by the 
Demand Registration are, at the time of the request of a Demand 
Registration, included in an effective registration statement and the 
Company is in compliance with its obligations under Subsection (d) (ii) 
through (v) hereof.

                     (iii)  The Company may suspend the effectiveness of 
any such registration effected pursuant to this Section 1.5(b) in the 
event, and for such period of time as, such a suspension is required by 
the rules and regulations of the Securities and Exchange Commission 
("SEC").

                     (iv)  If the registration statement covering the 
Registrable Securities is not effective within 105 days of the Closing, 
then the Company shall pay the Investor a one time penalty of 1.0% of 
the Purchase Price.

                 (c)  If the Company proposes to register (including for 
this purpose a registration effected by the Company for shareholders 
other than the Investor) any of its stock or other securities under the 
Act in connection with a public offering of such securities (other than 
a registration on Form S-4, Form S-8 or other limited purpose form) and 
the Registrable Securities have not heretofore been included in a 
registration statement under Subsection (b), which remains effective, 
the Company shall, at such time, promptly give the holder of Registrable 
Securities written notice of such registration.  Upon the written 
request of the holder of Registrable Securities given within twenty (20) 
days after receipt of such notice by the holder of Registrable 
Securities, the Company shall use its best efforts to cause to be 
registered under the Act all Registrable Securities that the holder of 
Registrable Securities requests to be registered.  However, the Company 
shall have no obligation under this Subsection (c) to the extent that, 
with respect to a public offering registration, any underwriter of such 
public offering reasonably requests that the Registrable Securities or a 
portion thereof be excluded therefrom.

                 (d)  Whenever required under this Section 1.5 to effect 
the registration of any Registrable Securities, including, without 
limitation, the Initial Registration, the Company shall, as 
expeditiously as reasonably possible:

                                   -4-

<PAGE>
                     (i)  Prepare and file with the SEC a registration 
statement with respect to such Registrable Securities and use its best 
efforts to cause such registration to become effective and, upon the 
request of the Investor, keep such registration statement effective, 
pursuant to the provisions of Regulation Setion 230.415 or otherwise, for so 
long as the holder of Registrable Securities desires to dispose of the 
securities covered by such registration statement (but not after the 
holder of Registrable Securities, in the reasonable opinion of its 
counsel, is free to sell such securities in any three month period under 
the provisions of Rule 144 under the Act).

                     (ii)  Prepare and file with the SEC such amendments 
and supplements to such registration statement and the prospectus used 
in connection with such registration statement as may be necessary to 
comply with the provisions of the Act with respect to the disposition of 
all securities covered by such registration statement.

                     (iii)  Furnish to the holder of Registrable 
Securities such numbers of copies of a prospectus, including a 
preliminary prospectus, in conformity with the requirements of the Act, 
and such other documents as the holder of Registrable Securities may 
reasonably require in order to facilitate the disposition of Registrable 
Securities owned by the holder of Registrable Securities.

                     (iv)  Use its best efforts to register and qualify 
the securities covered by such registration statement under such other 
securities or "Blue Sky" laws of such jurisdictions as shall be 
reasonably requested by the holder of Registrable Securities, provided 
that the Company shall not be required in connection therewith or as a 
condition thereto to qualify to do business or to file a general consent 
to service and process in any such states or jurisdictions.

                     (v)  Notify the holder of Registrable Securities of 
the happening of any event as a result of which the prospectus included 
in such registration statement, as then in effect, includes an untrue 
statement of material fact or omits to state a material fact required to 
be stated therein or necessary to make the statements therein not 
misleading in light of the circumstances then existing.

                     (vi)  Furnish, at the request of the holder of 
Registrable Securities, an opinion of counsel of the Company, dated the 
effective date of the registration statement, as to the due 
authorization and issuance of the securities being registered and 
compliance with securities laws by the Company in connection with the 
authorization and issuance thereof.

                     (vii)  Use its best efforts to list the Registrable 
Securities covered by such registration statement with any securities 
exchange on which the Common Stock is then listed;

                     (viii)  Make available for inspection by the holder 
of Registrable Securities, upon request, all SEC Documents filed 
subsequent to the Closing and require the Company's officers, directors 
and employees to supply all information reasonably requested by any 
holder of Registrable Securities in connection with such registration 
statement.

                 (e)  The holder of Registrable Securities will furnish 
to the Company in connection with any registration under this Section 
1.5 such information regarding itself, the Registrable Securities and 
other securities of the Company held by it, and the intended method of 
disposition of such securities as shall be required to effect the 
registration of the Registrable Securities held by holder of Registrable 
Securities.

                                  -5-
<PAGE>

                 (f)  (i)  The Company shall indemnify, defend and hold 
harmless each holder of Registrable Securities which are included in a 
registration statement pursuant to the provisions of Subsections (b) or 
(c) from and against, and shall reimburse such holder with respect to, 
any and all claims, suits, demands, causes of action, losses, damages, 
liabilities, costs or expenses ("Liabilities") to which such holder may 
become subject under the Act or otherwise, arising from or relating to 
(A) any untrue statement or alleged untrue statement of any material 
fact contained in such registration statement, any prospectus contained 
therein or any amendment or supplement thereto, or (B) the omission or 
alleged omission to state therein a material fact required to be stated 
therein or necessary to make the statements therein, in light of the 
circumstances in which they were made, not misleading; provided, 
however, that the Company shall not be liable in any such case to the 
extent that any such Liability arises out of or is based upon an untrue 
statement or alleged untrue statement or omission or alleged omission so 
made in conformity with information furnished by such holders in writing 
specifically for use in the preparation thereof.

                     (ii)  Promptly after receipt by the holder of 
Registrable Securities of notice of the commencement of any action, the 
holder of Registrable Securities shall, if a claim in respect thereof is 
to be made against the Company hereunder, notify the Company in writing 
thereof, but the omission so to notify the Company shall not relieve the 
Company from any Liability which it may have to the holder of 
Registrable Securities other than under this section and shall only 
relieve it from any Lability which it may have to the holder of 
Registrable Securities under this section if and to the extent the 
Company is prejudiced by such omission.  In case any such action shall 
be brought against the holder of Registrable Securities and the holder 
of Registrable Securities shall notify the Company of the commencement 
thereof, the Company shall be entitled to participate in and, to the 
extent it shall wish, to assume and undertake the defense thereof with 
counsel reasonably satisfactory to the holder of Registrable Securities, 
and, after notice from the Company to the holder of Registrable 
Securities of its election so to assume and undertake the defense 
thereof, the Company shall not be liable to the holder of Registrable 
Securities under this section for any legal expenses subsequently 
incurred by the holder of Registrable Securities in connection with the 
defense thereof other than reasonable costs of investigation and of 
liaison with counsel so selected, provided, however, that if the 
defendants in any such action include both the Company and the holder of 
Registrable Securities and the holder of Registrable Securities shall 
have reasonably concluded that there may be reasonable defenses 
available to it which are different from or additional to those 
available to the Company or if the interests of the holder of 
Registrable Securities reasonably may be deemed to conflict with the 
interests of the Company, the holder of Registrable Securities shall 
have the right to select a separate counsel and to assume such legal 
defenses and otherwise to participate in the defense of such action, 
with the expenses and fees of such separate counsel and other expenses 
related to such participation to be reimbursed by the Company as 
incurred.

                 (g)  (i)  With respect to the inclusion of Registrable 
Securities in a registration statement pursuant to subsections (b) or 
(c), all fees, costs and expenses of and incidental to such 
registration, inclusion and public offering shall be borne by the 
Company; provided, however, that any securityholders participating in 
such registration shall bear their pro rata share of the underwriting 
discounts and commissions, if any, incurred in connection with such 
registration.

                     (ii)  The fees, costs and expenses of registration 
to be borne by the Company as provided in this Subsection (g) shall 
include, without limitation, all registration, filing and NASD fees, 
printing expenses, fees and disbursements of counsel and accountants for 
the Company, and all legal fees and disbursements and other expenses of 
complying with state securities or Blue Sky laws of any jurisdiction or 
jurisdictions in which securities to be offered are to be 

                                   -6-
<PAGE>

registered and qualified.  Fees and disbursements of counsel and accountants 
for the selling securityholders shall, however, be borne by the respective 
selling securityholder.

                 (h)  (i) The rights to cause the Company to register 
all or any portion of Registrable Securities pursuant to this Section 
1.5 may be assigned by Investor to a transferee or assignee of 20% or 
more, in the aggregate, of the Shares and the Additional Shares.  Within 
a reasonable time after such transfer the Investor shall notify the 
Company of the name and address of such transferee or assignee and the 
securities with respect to which such registration rights are being 
assigned.  Such assignment shall be effective only if immediately 
following such transfer the further disposition of such securities by 
the transferee or assignee is restricted under the Act.  Any transferee 
shall agree in writing at the time of transfer to be bound by the 
provisions of this Section 1.5.

                     (ii)  From and after the date of this Agreement, 
the Company shall not agree to allow the holders of any securities of 
the Company to include any of their securities in any registration 
statement filed by the Company pursuant to Subsection (b) unless the 
inclusion of such securities will not reduce the amount of the 
Registrable Securities included therein.

            Section 1.6.  ADJUSTMENTS.  If the Investor shall be 
entitled to the issuance of Additional Shares, the Company shall deliver 
to the Investor at the offices of the Investor on the third (3rd) 
business day after the end of the Valuation Period one or more 
certificates representing the Additional Shares so to be delivered in 
accordance with this Agreement, registered in the name of the Investor, 
or deposit such Additional Shares into accounts designated by the 
Investor; provided, however, that if the sum of the shares then 
beneficially owned by the Investor, and any Additional Shares then 
issuable to the Investor, as determined by the Investor, in its sole 
determination, shall equal 1.66% or more of the shares of Company's 
Common Stock issued and outstanding (as determined in accordance with 
Section 13(d) of the Securities Exchange Act of 1934) just prior to the 
Closing, then, and in such event, (x) the number of Additional Shares to 
be issued to the Investor pursuant to this paragraph shall be reduced to 
the number which, together with the Share Number, shall equal 1.64% of 
the shares of the Company's Common Stock issued and outstanding (as so 
determined) just prior to the Closing, and (y) in consideration for such 
reduction in Additional Shares, the Company shall pay to the Investor a 
sum equal to the greater of (a) the product of 88.5% of the Average 
Share Price and the reduction in the Additional Shares to be issued as a 
result of the preceding clause (x), and (b) the product of the 
Subsequent Sale Price and the reduction in the Additional Shares to be 
issued as a result of the preceding clause (x).

            Section 1.7  RESCHEDULING.  If after the date hereof and 
prior to the expiration of the Valuation Period any person shall (a) 
publicly announce a tender offer or exchange offer for the Company's 
Common Stock, or (b) publicly announce plans for a merger, consolidation 
or potential change in control of the Company, the Investor may in its 
sole discretion elect by written notice to the Company to shorten the 
Valuation Period so as to end on a date which is either before or after 
the consummation of the record date for the consummation of any such 
transaction, which election must be made prior to consummation of any 
such transaction.  For purposes of the foregoing, it is understood and 
agreed that the Investor may, but shall not be required to, reduce or 
entirely eliminate the Valuation Period or to reschedule the Valuation 
Period.

                                  -7-
<PAGE>

                               ARTICLE II

                     Representations and Warranties
                     ------------------------------

            Section 2.1  REPRESENTATIONS AND WARRANTIES OF THE COMPANY.  
The Company hereby makes the following representations and warranties to 
the Investor:

                 (a)  ORGANIZATION AND QUALIFICATION.  The Company is a 
corporation duly incorporated and existing in good standing under the 
laws of the State of Delaware, and has the requisite corporate power to 
own its properties and to carry on its business as now being conducted.  
The Company does not have any active subsidiaries, except for those  
identified in the SEC Documents (as hereinafter defined).  Each of the 
Company and its subsidiaries is duly qualified as a foreign corporation 
to do business and is in good standing in every jurisdiction in which 
the nature of the business conducted or property owned by it makes such 
qualification necessary and where the failure so to qualify would have a 
Material Adverse Effect.  "Material Adverse Effect" means any  adverse 
effect on the operations, properties, prospects, or financial condition 
of the entity with respect to which such term is used and which is 
material to such entity and other entities controlling or controlled by 
such entity taken as a whole.

                 (b)  AUTHORIZATION; ENFORCEMENT.  (i)  The Company has 
the requisite corporate power and authority to enter into and perform 
this Agreement and to issue the Shares and the Additional Shares in 
accordance with the terms hereof, (ii) the execution and delivery of 
this Agreement by the Company and the consummation by it of the 
transactions contemplated hereby have been duly authorized by all 
necessary corporate action, and no further consent or authorization of 
the Company or its Board of Directors or stockholders is required, (iii) 
this Agreement has been duly executed and delivered by the Company, and 
(iv) this Agreement constitutes a valid and binding obligation of the 
Company enforceable against the Company in accordance with its terms, 
except as such enforceability may be limited by applicable bankruptcy, 
insolvency, reorganization, moratorium, liquidation or similar laws 
relating to, or affecting generally the enforcement of, creditors' 
rights and remedies or by other equitable principles of general 
application.

                 (c)  CAPITALIZATION.  The authorized capital stock of 
the Company  and the shares thereof currently issued and outstanding are 
as most recently described in the SEC Documents and there have been no 
changes (except for changes described on EXHIBIT A) therein since such 
description. All of the outstanding shares of the Company's Common Stock 
have been validly issued and are fully paid and nonassessable.  Except 
as set forth in EXHIBIT A hereto and as described in the SEC Documents, 
no shares of Common Stock are entitled to preemptive rights and there 
are no outstanding options, warrants, scrip, rights to subscribe to, 
calls or commitments of any character whatsoever relating to, or 
securities or rights convertible into, any shares of capital stock of 
the Company, or contracts, commitments, understandings, or arrangements 
by which the Company is or may become bound to issue additional shares 
of capital stock of the Company or options, warrants, scrip, rights to 
subscribe to, or commitments to purchase or acquire, any shares, or 
securities or rights convertible into shares, of capital stock of the 
Company.  The Company has furnished to the Investor true and correct 
copies of the Company's Certificate of Incorporation as in effect on the 
date hereof (the "Certificate"), and the Company's By-Laws, as in effect 
on the date hereof (the "By-Laws").

                 (d)  ISSUANCE OF SHARES.  The issuance of the Shares 
and Additional Shares has been duly authorized and, when paid for or 
issued in accordance with the terms hereof, shall be validly issued, 
fully paid and non-assessable.

                                  -8-
<PAGE>

                 (e)  NO CONFLICTS.  The execution, delivery and 
performance of this Agreement by the Company and the consummation by the 
Company of the transactions contemplated hereby do not and will not (i) 
result in a violation of the Company's Certificate or By-Laws or (ii) 
conflict with, or constitute a default (or an event which with notice or 
lapse of time or both would become a default) under, or give to others 
any rights of termination, amendment, acceleration or cancellation of, 
any agreement, indenture or instrument to which the Company is a party 
and which has previously been filed as an exhibit to the Company's Form 
10-K for the year ended December 31, 1994 and is still in effect, or 
result in a violation of any federal, state, local or foreign law, rule, 
regulation, order, judgment or decree (including Federal and state 
securities laws and regulations) applicable to the Company, or by which 
any property or asset of the Company is bound or affected (except for 
such conflicts, defaults, terminations, amendments, accelerations, 
cancellations and violations as would not, individually or in the 
aggregate, have a Material Adverse Effect); provided that, for purposes 
of such representation as to Federal, state, local or foreign law, rule 
or regulation, no representation is made herein with respect to any of 
the same applicable solely to the Investor and not to the Company.  The 
business of the Company is not being conducted in violation of any law, 
ordinance or regulations of any governmental entity, except for possible 
violations which either singly or in the aggregate do not have a 
Material Adverse Effect.  The Company is not required under Federal, 
state or local law, rule or regulation in the United States to obtain 
any consent, authorization or order of, or make any filing or 
registration with, any court or governmental agency in order for it to 
execute, deliver or perform any of its obligations under this Agreement 
or issue and sell the Shares or the Additional Shares in accordance with 
the terms hereof (other than the filing of a Form D with the SEC, any 
NASD filings or state securities filings which may be required to be 
made by the Company subsequent to the Closing, and any registration 
statement which may be filed in accordance with Section 1.5 herein); 
provided that, for purposes of the representation made in this sentence, 
the Company is assuming and relying upon the accuracy of the relevant 
representations and agreements of the Investor herein.

                 (f)  SEC DOCUMENTS, FINANCIAL STATEMENTS.  The Common 
Stock of the Company is registered pursuant to Section 12(g) of the 
Securities and Exchange Act of 1934, as amended (the "Exchange Act") and 
the Company has filed all reports, schedules, forms, statements and 
other documents required to be filed by it with the SEC pursuant to the 
reporting requirements of the Exchange Act, including material filed 
pursuant to Section 13(a) or 15(d), in addition to one or more 
registration statements and amendments thereto heretofore filed by the 
Company with the SEC (all of the foregoing filed prior to the date 
hereof being hereinafter referred to herein as the "SEC Documents").  
The Company has delivered to the Investor true and complete copies of 
the quarterly and annual (including, without limitation, proxy 
information and solicitation materials) SEC Documents filed with the SEC 
since December 31, 1994.  The Company has not provided to the Investor 
any information which, according to applicable law, rule or regulation, 
should have been disclosed publicly by the Company but which has not 
been so disclosed, other than with respect to the transactions 
contemplated by this Agreement.  As of their respective dates, the SEC 
Documents complied in all material respects with the requirements of the 
Exchange Act and the rules and regulations of the SEC promulgated 
thereunder and other federal, state and local laws, rules and 
regulations applicable to such SEC Documents, and none of the SEC 
Documents contained any untrue statement of a material fact or omitted 
to state a material fact required to be stated therein or necessary in 
order to make the statements therein, in light of the circumstances 
under which they were made, not misleading.  The financial statements of 
the Company included in the SEC Documents comply as to form in all 
material respects with applicable accounting requirements and the 
published rules and regulations of the SEC or other applicable rules and 
regulations with respect thereto.  Such financial statements have been 
prepared in accordance with generally accepted accounting principles 
applied on a consistent basis during the periods involved (except (i) as 
may be otherwise indicated in 

                                 -9-
<PAGE>

such financial statements or the notes thereto or (ii) in the case of 
unaudited interim statements, to the extent they may not include footnotes 
or may be condensed or summary statements) and fairly present in all 
material respects the financial position of the Company as of the dates 
thereof and the results of operations and cash flows for the periods then 
ended (subject, in the case of unaudited statements, to normal year-end 
audit adjustments).

                 (g)  NO MATERIAL ADVERSE CHANGE.  Since December 31, 
1994,  the date through which the most recent annual report of the 
Company on Form 10-K has been prepared and filed with the SEC, a copy of 
which is included in the SEC Documents, no Material Adverse Effect has  
occurred or exists with respect to the Company except as otherwise 
disclosed or reflected in other SEC Documents prepared through or as of 
a date subsequent to December 31, 1994.

                 (h)  NO UNDISCLOSED LIABILITIES.  The Company has no 
liabilities or obligations not disclosed in the SEC Documents, other 
than those incurred in the ordinary course of the Company's business 
since March 31, 1995 and which, individually or in the aggregate, do not 
or would not have a Material Adverse Effect on the Company.

                 (i)  NO UNDISCLOSED EVENTS OR CIRCUMSTANCES.  No event 
or circumstance has occurred or exists with respect to the Company or 
its business, properties, prospects, operations or financial condition, 
which, under applicable law, rule or regulation, requires public 
disclosure or announcement by the Company but which has not been so 
publicly announced or disclosed.

            Section 2.2  REPRESENTATIONS AND WARRANTIES OF THE INVESTOR.  
The Investor hereby makes the following representations and warranties 
to the Company:

                 (a)  AUTHORIZATION; ENFORCEMENT.  (i)  The Investor has 
the requisite power and authority to enter into and perform this 
Agreement and to purchase the Shares being sold hereunder, (ii) the 
execution and delivery of this Agreement by the Investor and the 
consummation by it of the transactions contemplated hereby have been 
duly authorized by all necessary corporate action, and no further 
consent or authorization of the Investor or its Board of Directors, 
stockholders, or partners as the case may be, is required, (iii) this 
Agreement has been duly authorized, executed and delivered by the 
Investor, and (iv) this Agreement constitutes a valid and binding 
obligation of the Investor enforceable against the Investor in 
accordance with its terms, except as enforceability may be limited by 
applicable bankruptcy, insolvency, reorganization, moratorium, 
liquidation or similar laws relating to, or affecting generally the 
enforcement of, creditors' rights and remedies or by other equitable 
principles of general application.

                 (b)  NO CONFLICTS.  The execution, delivery and 
performance of this Agreement and the consummation by the Investor of 
the transactions contemplated hereby or relating hereto do not and will 
not (i) result in a violation of the Investor's charter documents or By-
Laws or (ii) conflict with, or constitute a default (or an event which 
with notice or lapse of time or both would become a default) under, or 
give to others any rights of termination, amendment, acceleration or 
cancellation of any agreement, indenture or instrument to which the 
Investor is a party, or result in a violation of any law, rule, or 
regulation, or any order, judgment or decree of any court or 
governmental agency applicable to the Investor or its properties (except 
for such conflicts, defaults and violations as would not, individually  
or in the aggregate have a Material Adverse Effect on the Investor).  
The businesses of the Investor are not being conducted in violation of 
any law, ordinance or regulation of any governmental entity, except for 
possible violations which either singly or in the aggregate do not have 
a Material Adverse Effect.  The Investor is not required to obtain any 
consent, authorization or order of, or make any filing or registration 
with, any court or governmental agency in 

                                 -10-
<PAGE>

order for it to execute, deliver or perform any of its obligations under 
this Agreement or purchase the Shares or the Additional Shares in accordance 
with the terms hereof; provided that for purposes of the representation 
made in this sentence, the Investor is assuming and relying upon the 
accuracy of the relevant representations and agreements of the Company herein.

                 (c)  OWNERSHIP. The Investor is duly organized and 
validly existing under the laws of the place hereinabove provided and is 
not a U.S. Person as defined within Regulation S under the Securities 
Act and is not purchasing the Shares for the account or benefit of a 
U.S. Person.  On the date hereof and on the Closing Date, the Investor 
is and will be, as the case may be, located outside of the United 
States.  The Investor has such knowledge and experience in financial and 
business matters that it is capable of evaluating the merits and risks 
of the investment contemplated by this Agreement.  The Investor has been 
afforded, to the satisfaction of the Investor, the opportunity to review 
the SEC Documents and obtain such additional publicly available 
information concerning the Company and its business, and to ask such 
questions and receive such answers (based upon publicly available 
information), as the Investor deems necessary to make an informed 
investment decision.

                 (d)  INVESTMENT REPRESENTATION:  The Investor is 
purchasing the Shares and, if any, the Additional Shares for investment 
purposes and not with a view towards distribution.  Investor has no 
present intention to sell the Shares or the Additional Shares and the 
Investor has no present arrangement (whether or not legally binding) at 
any time to sell the Shares or the Additional Shares to or through any 
person or entity; provided, however, except as provided in subsection 
(g) below, that by making the representations herein, the Investor does 
not agree to hold the Shares or the Additional Shares for any minimum or 
other specific term and reserves the right to dispose of the Shares or 
the Additional Shares at any time in accordance with Federal securities 
laws applicable to such disposition.

                 (e)  ACCREDITED INVESTOR:  The Investor is an 
accredited investor as defined in Regulation Section 230.501 promulgated under 
the Act.

                 (f)  RULE 144.  The Investor understands that the 
Shares and any Additional Shares must be held indefinitely unless such 
Shares or Additional Shares are subsequently registered under the Act or 
an exemption from registration is available.  The Investor has been 
advised or is aware of the provisions of Rule 144 promulgated under the 
Act.

                 (g)  Notwithstanding the foregoing, the Investor shall 
not sell (including a short sale), transfer or otherwise dispose of the 
shares, or any Additional Shares issued to such Investor, at any time 
during the 105 day period following the Closing.  Notwithstanding the 
foregoing, during the Valuation Period Investor will only transfer or 
otherwise dispose of its shares in accordance with the representations 
contained in EXHIBIT C.


                               ARTICLE III

                               Covenants
                               ---------

            Section 3.1  REGULATION S

                (a)  Notwithstanding any of the foregoing, the Company 
acknowledges and agrees that in the event that a registration statement 
covering all of the Registrable Securities shall not have become 
effective within 105 days of the Closing Date, legend described in 
Article V herein shall 

                                 -11-
<PAGE>

be removed on the 106th day following the Closing, in accordance with 
Article V herein, it being acknowledged by the Company that, in such event, 
the Investor shall be free to transfer, sell, pledge, or otherwise 
hypothecate the Shares and the Additional Shares issued pursuant to this 
Agreement in accordance with (a) Regulation S under the Act and (b) the 
terms and conditions described in the letter attached hereto as EXHIBIT C.

                 (b)  The Company acknowledges and agrees that, in the 
event the Investor sells, transfers, pledges or otherwise hypothecates 
the Shares or Additional Shares in accordance with Section 3.1(a) 
herein, for purposes of clarifying and specifying the applicable 
Restricted Period under Regulation S, the Investor intends to observe as 
the Restricted Period (as defined in Regulation S) for the Shares being 
delivered at the Closing the period of 40 days commencing upon the 
Closing Date and ending 40 days thereafter, and to observe as the 
Restricted Period applicable to the Additional Shares, if any, the 
period of 40 days commencing upon the date upon which the same are 
delivered to the Investor hereunder.

                 Neither the Company nor any of its affiliates has 
engaged or will engage in any "directed selling efforts" (as such term 
is defined under Regulation S) with respect to the Shares or the 
Additional Shares, and the Company and its affiliates have complied and 
will comply with the "offering restrictions" requirements of Regulation 
S.

                 (c)  In the event the Investor sells, transfers or 
otherwise disposes of the Shares or the Additional Shares in accordance 
with Section 3.1(a) herein, the Investor covenants and agrees that such 
sale, transfer or other disposition will be made in compliance with the 
terms of Regulation S under the Act, as in effect at that time, 
including (i) that the Shares and the Additional Shares will not be 
offered or sold within the United States or to, or for the account or 
benefit of, any "U.S. person" (as such term is defined in Rule 902 (o) 
promulgated under the Act) except in accordance with the provisions of 
Rule 903 or Rule 904 of Regulation S under the Securities Act, pursuant 
to registration under the Act, or pursuant to an exemption from the 
registration requirements of the Act and (ii) that neither it, its 
affiliates, nor persons acting on their behalf, have engaged or will 
engage in "directed selling efforts" (as such term is defined by 
Regulation S) with respect to the Shares or the Additional Shares and 
that each of them has complied and will comply with the "offering 
restrictions" requirements of Regulation S.


            Section 3.2  SECURITIES COMPLIANCE.

                 (a)  The Company shall notify the SEC and Nasdaq, in 
accordance with its requirements, of the transactions contemplated by 
this Agreement, and shall take all other necessary action and 
proceedings as may be required and permitted by applicable law, rule and 
regulation, including, without limitation, the filing of a Form D with 
the SEC, for the legal and valid issuance of the Shares and the 
Additional Shares to the Investor.

                 (b)  The Investor understands that the Shares and, if 
any, the Additional Shares, are being offered and sold to it in reliance 
on a transactional exemption from the registration 

                                   -12-
<PAGE>

requirements of Federal and state securities laws and that the Company is 
relying upon the truth and accuracy of the representations, warranties, 
agreements, acknowledgments and understandings of such Investor set forth 
herein in order to determine the applicability of such exemptions and the 
suitability of such Investor to acquire the Shares.

            Section 3.3  CORPORATE.  (a) From the date hereof through 
the end of the Valuation Period the Company shall not (i) amend its 
Certificate or By-Laws so as to adversely affect any rights of the 
Investor; (ii) split, combine or reclassify its outstanding capital 
stock; (iii) declare or set aside or pay any dividend or other 
distribution with respect to the Company's outstanding Common Stock; 
(iv) issue or sell, directly or indirectly, Shares of the Company's 
Common Stock in a manner or upon terms as could reasonably be expected 
to affect the market for the Common Stock materially and adversely; or 
(v) enter into any agreement with respect to the foregoing; and (vi) the 
Company shall at all times reserve and keep available, solely for 
issuance and delivery as Shares or Additional Shares hereunder, such 
shares of Common Stock as shall from time to time be issuable or 
reasonably be expected to be issuable as Shares or Additional Shares 
hereunder provided, however, that the number of shares so reserved shall 
at all times be at least 300% of the Share Number.

                 (b)  The Company will cause its Common Stock to 
continue to be registered under Sections 12(b) or 12(g) of the Exchange 
Act, will comply in all respects with its reporting and filing 
obligations under said act, will comply with all requirements related to 
any registration statement filed pursuant to Section 1.5 herein, and 
will not take any action or file any document (whether or not permitted 
by said Act or the rules thereunder) to terminate or suspend such 
registration or to terminate or suspend its reporting and filing 
obligations under said act, except as permitted herein.  The Company 
will take all action necessary to continue the listing or trading of its 
Common Stock on the Nasdaq National Market and will comply in all 
respects with the Company's reporting, filing and other obligations 
under the bylaws or rules of the NASD and Nasdaq.


                               ARTICLE IV

                               Conditions
                               ----------

            Section 4.1  CONDITIONS PRECEDENT TO THE OBLIGATION OF THE 
COMPANY TO SELL THE SHARES. The obligation hereunder of the Company to 
issue and/or sell the Shares or the Additional Shares to the Investor is 
further subject to the satisfaction, at or before the respective 
issuance and deliveries thereof, of each of the following conditions set 
forth below.  These conditions are for the Company's sole benefit and 
may be waived by the Company at any time in its sole discretion.

                 (a)  ACCURACY OF THE INVESTOR REPRESENTATIONS AND 
WARRANTIES.  The representations and warranties of the Investor shall be 
true and correct in all material respects as of the date when made and 
as of the date of such issuance and delivery as though made at that 
time.

                 (b)  PERFORMANCE BY THE INVESTOR.  The Investor shall 
have performed, satisfied and complied in all material respects with all 
covenants, agreements and conditions required by this Agreement to be 
performed, satisfied or complied with by the Investor at or prior to 
such date.

                 (c)  NO INJUNCTION.  No statute, rule, regulation, 
executive order, decree, ruling or injunction shall have been enacted, 
entered, promulgated or endorsed by any court or governmental authority 
of competent jurisdiction which  prohibits the consummation of any of 
the transactions contemplated by this Agreement.

                                  -13-
<PAGE>

            Section 4.2  CONDITIONS PRECEDENT TO THE OBLIGATION OF THE 
INVESTOR TO PURCHASE THE SHARES.  The obligation of the Investor 
hereunder to acquire and pay for the Shares is subject to the 
satisfaction, at or before the Closing of each of the following 
conditions set forth below.  These conditions are for the Investor's 
sole benefit and may be waived by the Investor at any time in its sole 
discretion.

                 (a)  ACCURACY OF THE COMPANY'S REPRESENTATIONS AND 
WARRANTIES.  The representations and warranties of the Company shall be 
true and correct in all material respects as of the date when made and 
as of the Closing Date as though made at that time (except for 
representations and warranties that speak as of a particular date).

                 (b)  PERFORMANCE BY THE COMPANY.  The Company shall 
have performed, satisfied and complied in all material respects with all 
covenants, agreements and conditions required by this Agreement to be 
performed, satisfied or complied with by the Company at or prior to the 
Closing.

                 (c)  NASDAQ.  From the date hereof to the Closing Date, 
as to the Shares to be issued and delivered on the Closing Date, trading 
in the Company's Common Stock shall not have been suspended by the SEC 
or the Nasdaq National Market (except for any suspension of trading of 
limited duration agreed to between the Company and the Nasdaq National 
Market solely to permit dissemination of material information regarding 
the Company), and trading in securities generally as reported by Nasdaq 
shall not have been suspended or limited or minimum prices shall not 
have been established on securities whose trades are reported by Nasdaq.  
Notwithstanding the foregoing sentence, in the event that at any point 
on or prior to the first day of the Valuation Period trading in the 
Common Stock is suspended by the SEC or the Nasdaq National Market, 
(i) calculation of the Average Stock Price shall be suspended for such 
period of time as trading in the Common Stock is suspended and (ii) the 
Valuation Period shall be reset so that such Valuation Period shall 
begin on the 90th calendar day following the Closing Date and shall end 
on the 45th calendar day thereafter on which quotations for the 
Company's Common Stock on the Nasdaq National Market are available.  In 
the event that the Company's Common Stock is delisted from the Nasdaq 
National Market at any time during the Valuation Period or in the event 
that trading in the Common Stock is suspended for a period of more than 
thirty (30) days subsequent to the commencement of the Valuation Period, 
(iii) the Valuation Period will be deemed to have concluded on the date 
on which the Common Stock was delisted or such trading was suspended, 
(iv) the Average Stock Price shall be calculated based on the number of 
days in such shortened Valuation Period, and (v) the Investor shall 
receive any Additional Shares owed to it pursuant to Section 1.3(c) 
herein within five (5) business days of the conclusion of the shortened 
Valuation Period.  In no event shall the Investor be required to deliver 
any shares for cancellation pursuant to Section 1.3(d) herein if the 
Common Stock is delisted from the Nasdaq National Market or if trading 
in the Common Stock is suspended for more than thirty (30) days during 
the Valuation Period or prior to the effectiveness of the Company's 
Initial Registration.

                 (d)  NO INJUNCTION.  No statute, rule, regulation, 
executive order, decree, ruling or injunction shall have been enacted, 
entered, promulgated or endorsed by any court or governmental authority 
of competent jurisdiction which prohibits the consummation of any of the 
transactions contemplated by this Agreement.

                                 -14-
<PAGE>

                 (e)  OPINION OF COUNSEL, ETC.  At the Closing the 
Investor shall have received an opinion of Brobeck Phleger & Harrison, 
counsel to the Company, in form and substance satisfactory to the 
Investor and its counsel (in substantially the form of Exhibit B 
hereto), and such other certificates and documents as the Investor or 
its counsel shall reasonably require incident to the Closing.


                                ARTICLE V

                             Legend on Stock
                             ---------------

            Each certificate representing the Shares issued pursuant to 
Section 1.3 shall be stamped or otherwise imprinted with a legend 
substantially in the following form:

          THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE 
          SECURITIES ACT OF 1933 OR ANY STATE SECURITIES LAWS.  
          THEY MAY NOT BE SOLD OR OFFERED FOR SALE IN THE 
          ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO 
          THE SECURITIES UNDER SAID ACT AND ANY APPLICABLE 
          STATE SECURITIES LAW OR AN APPLICABLE EXEMPTION FROM 
          THE REGISTRATION REQUIREMENTS OF THE ACT.  THIS 
          LEGEND SHALL CEASE TO HAVE ANY FORCE OR EFFECT AND 
          WILL BE REMOVED ON OCTOBER 7, 1995 UNLESS AN OPINION 
          OF COUNSEL TO THE COMPANY, IN FORM AND SUBSTANCE 
          SATISFACTORY TO THE INVESTOR AND ITS COUNSEL, IS 
          DELIVERED TO THE COMPANY'S TRANSFER AGENT ON OR 
          PRIOR TO SUCH DATE STATING THAT REMOVAL OF THIS 
          LEGEND IS NOT PERMITTED UNDER LAW DUE TO A CHANGE IN 
          LAW SUBSEQUENT TO JUNE 23, 1995.

            Notwithstanding the foregoing, this legend shall cease to 
have any force or effect and will be removed on October 7, 1995, unless 
an opinion of counsel to the Company, in form and substance satisfactory 
to the Investor and its counsel, is delivered to the Company's transfer 
agent, on or prior to such date stating that removal of this legend is 
not permitted under law due to a change in law subsequent to the date 
hereof.

            No certificate representing Additional Shares, if any, 
required to be issued pursuant to this Agreement will bear a restrictive 
legend unless an opinion of the Company's counsel, in form and substance 
satisfactory to the Investor, has been issued to the Company's transfer 
agent on or prior to the issuance of such Additional Shares stating that 
such a legend is required by law due to a change in law subsequent to 
the date hereof.


                               ARTICLE VI

                               Termination
                               -----------

            Section 6.1  TERMINATION BY MUTUAL CONSENT.  This Agreement 
may be terminated at any time prior to the Closing by the mutual consent 
of the Company and the Investor, by action of their respective Boards of 
Directors or other governing body.

                                   -15-
<PAGE>

            Section 6.2  OTHER TERMINATION.  This Agreement may be 
terminated by action of the Board of Directors or other governing body 
of the Investor or the Company at any time after June 23 1995 if the 
Closing shall not have been consummated by June 23, 1995.

            Section 6.3  AUTOMATIC TERMINATION.  This Agreement shall 
automatically terminate without any further action of either party 
hereto if the Closing shall not have occurred by June 23, 1995.


                               ARTICLE VII

                              Miscellaneous
                              -------------

            Section 7.1  FEES AND EXPENSES.  Each party shall pay the 
fees and expenses of its advisers, counsel, accountants and other 
experts, if any, and all other expenses incurred by such party incident 
to the negotiation, preparation, execution, delivery and performance of 
this Agreement, provided that the Company shall pay, at the Closing, all 
attorneys' fees and expenses incurred by the Investor and Cappello 
Capital Corp., up to a maximum of $6,666, in connection with the 
preparation, negotiation, execution and delivery of this Agreement and 
the transactions contemplated hereunder.  Without limiting the 
generality of the foregoing, The Kriegsman Group shall be entitled to a 
finders fee pursuant to a separate agreement with respect thereto 
between such finder and the Company, and the Company shall be solely 
responsible for the full payment thereof and shall indemnify and hold 
harmless the Investor from and against all loss, cost, damage or expense 
arising therefrom.  The Company shall pay all stamp and other taxes and 
duties levied in connection with the issuance of the Shares or the 
Additional Shares pursuant hereto.

            Section 7.2  SPECIFIC ENFORCEMENT; CONSENT TO JURISDICTION.

                 (a)  The Company and the Investor acknowledge and agree 
that irreparable damage would occur in the event that any of the 
provisions of this Agreement were not performed in accordance with their 
specific terms or were otherwise breached.  It is accordingly agreed 
that the parties shall be entitled to an injunction or injunctions to 
prevent or cure breaches of the provisions of this Agreement and to 
enforce specifically the terms and provisions hereof, this being in 
addition to any other remedy to which either of them may be entitled by 
law or equity.

                 (b)  Each of the Company and the Investor (i) hereby 
irrevocably submits to the exclusive jurisdiction of the United States 
District Court and other courts of the United States sitting in New York 
for the purposes of any suit, action or proceeding arising out of or 
relating to this  Agreement and (ii) hereby waives, and agrees not to 
assert in any such suit, action or proceeding, any claim that it is not 
personally subject to the jurisdiction of such court, that the suit, 
action or proceeding is brought in an inconvenient forum or that the 
venue of the suit, action or proceeding is improper.  Each of the 
Company and the Investor consents to process being served in any such 
suit, action or proceeding by mailing a copy thereof to such party at 
the address in effect for notices to it under this Agreement and agrees 
that such service shall constitute good and sufficient service of 
process and notice thereof.  Nothing in this paragraph shall affect or 
limit any right to serve process in any other manner permitted by law.

            Section 7.3  ENTIRE AGREEMENT; AMENDMENTS.  This Agreement 
contains the entire understanding of the parties with respect to the 
matters covered hereby and thereby and, except as 

                                -16-
<PAGE>

specifically set forth herein, neither the Company nor the Investor makes 
any representation, warranty, covenant or undertaking with respect to such 
matters.  No provision of this Agreement may be waived or amended other 
than by a written instrument signed by the party against whom enforcement 
of any such amendment or waiver is sought.

            Section 7.4  NOTICES.  Any notice or other communication 
required or permitted to be given hereunder shall be in writing and 
shall be effective (a) upon hand delivery or delivery by telex (with 
correct answer back received), telecopy or facsimile at the address or 
number designated below (if delivered on a business day during normal 
business hours where such notice is to be received), or the first 
business day following such delivery (if delivered other than on a 
business day during normal business hours where such notice is to be 
received) or (b) on the second business day following the date of 
mailing by express courier service, fully prepaid, addressed to such 
address, or upon actual receipt of such mailing, whichever shall first 
occur.  The addresses for such communications shall be:

            to the Company:

                             Advanced Tissue Sciences, Inc.
                             10933 North Torrey Pines Road
                             La Jolla, California 92037
                             Attn:  Chief Executive Officer

            with copies to:

                             Brobeck Phleger & Harrison
                             4675 MacArthur Court
                             Suite 1000
                             Newport Beach, California 92660
                             Attn:  Laura M. Brower, Esq.

            to the Investor:

                             Steinhardt Overseas Fund Ltd.
                             c/o Bank of Bermuda Ltd.
                             Corp. Trust Services Department
                             Attn:  Stewart Bent
                             129 Front St.
                             Hamilton 5-31
                             Bermuda


            with copies to:

                             The Palladin Group, L.P.
                             40th West 57th Street
                             Suite 1500
                             New York, New York 10019
                             Attn:  Jeffrey Devers

                                    -17-
<PAGE>

Either party hereto may from time to time change its address for notices 
under this Section 7.4 by giving at least 10 days' written notice of 
such changed address to the other party hereto.

            Section 7.5  WAIVERS.  No waiver by either party of any 
default with respect to any provision, condition or requirement of this 
Agreement shall be deemed to be a continuing waiver in the future or a 
waiver of any other provision, condition or requirement hereof, nor 
shall any delay or omission of either party to exercise any right 
hereunder in any manner impair the exercise of any such right accruing 
to it thereafter.

            Section 7.6  HEADINGS.  The headings herein are for 
convenience only, do not constitute a part of this Agreement  and shall 
not be deemed to limit or affect any of the provisions hereof.

            Section 7.7  SUCCESSORS AND ASSIGNS.  This Agreement shall 
be binding upon and inure to the benefit of the parties and their 
successors and assigns.  The parties hereto may amend this Agreement 
without notice to or the consent of any third party.  Neither the 
Company nor the Investor shall assign this Agreement or any rights or 
obligations hereunder without the prior written consent of the other 
(which consent may be withheld for any reason in the sole discretion of 
the party from whom consent is sought); provided, however, that the 
Company may assign its rights and obligations hereunder to any acquirer 
of substantially all of the assets or a controlling equity interest of 
the Company.  The assignment by a party of this Agreement or any rights 
hereunder shall not affect the obligations of such party under this 
Agreement.

            Section 7.8  NO THIRD PARTY BENEFICIARIES.  This Agreement 
is intended for the benefit of the parties hereto and their respective 
permitted successors and assigns and is not for the benefit of, nor may 
any provision hereof be enforced by, any other person.

            Section 7.9  GOVERNING LAW.  This Agreement shall be 
governed by and construed and enforced in accordance with the internal 
laws of Delaware without regard to the principles of conflict of laws.

            Section 7.10  SURVIVAL. The representations and warranties 
of the Company and the Investor contained in Article II and the 
agreements and covenants set forth in Articles I and III shall survive 
the Closing.

            Section 7.11  EXECUTION.  This Agreement may be executed in 
two or more counterparts, all of which shall be considered one and the 
same agreement and shall become effective when counterparts have been 
signed by each party and delivered to the other party, it being 
understood that both parties need not sign the same counterpart.  In the 
event any signature is delivered by facsimile transmission, the party 
using such means of delivery shall cause four additional executed 
signature pages to be physically delivered to the other party within 
five days of the execution and delivery hereof.

            Section 7.12  PUBLICITY.  The Company and the Investor shall 
consult and cooperate with each other in issuing any press releases or 
otherwise making public statements with respect to the transactions 
contemplated hereby, provided the foregoing shall not interfere with the 
legal obligations of either party with respect to public disclosure; and 
provided further, that neither the Company nor the Investor shall be 
required to consult with the other if any such press release or public 
statement does not specifically name the other.


              [Remainder of page intentionally left blank.]

                                 -18-
<PAGE>


            IN WITNESS WHEREOF, the parties hereto have caused this 
Agreement to be duly executed by their respective authorized officers as 
of the date hereof.

                                    ADVANCED TISSUE SCIENCES, INC.


                                    By:  /s/ Arthur J. Benvenuto
                                         ----------------------------
                                         Name:  Arthur J. Benvenuto
                                         Its:  Chairman, President & CEO


                                    STEINHARDT OVERSEAS FUND LTD.

                                    By:  The Palladin Group, L.P., its 
                                         investment manager

                                         By: Palladin Capital Management, LLC
                                             Its General Partner


                                             By:  /s/  Jeffrey Devers
                                                 ---------------------
                                                 Title:  President







                                   -19-


                                                                  EXHIBIT A

                            CAPITALIZATION SUMMARY


The following table reconciles the Company's outstanding Common Stock and 
options and warrants as reported in the Company's Quarterly Report on 
Form 10-Q as of March 31, 1995 to June 13, 1995.

                                           Common         Options and
                                            Stock          Warrants
                                          Outstanding     Outstanding
                                         -------------   -------------

   Outstanding per Form 10-Q             30,570,993       4,186,957
   Options and warrants exercised           561,200        (561,200)
   Options and warrants granted                   -         125,000
   Options and warrants canceled                  -        (139,209)
                                         ----------       ---------

   Outstanding as of June 13, 1995       31,132,193       3,611,548
                                         ==========       =========


As of June 13, 1995, the Company had 1,900,462 remaining available for 
grant under its 1992 Stock Option/Stock Issuance Plan.

The Company will issue warrants to purchase 135,000 shares of Common Stock 
to the placement agents involved in this transaction on the Closing Date at 
an initial exercise price of $6.86 per share.

On January 5, 1995, the Company's Board of Directors (the "Board") adopted 
a Shareholder Rights Plan (the "Rights Plan").  Pursuant to the Rights 
Plan, the Board declared a dividend of one preferred share purchase right 
(the "Right") for each share of Common Stock outstanding on January 20, 1995.  
Each Right entitles the registered holder to purchase from the Company 
one-hundredth of a share of Series A Junior Participating Preferred Stock 
at an exercise price of $55 per one-hundredth share, subject to adjustment.


<PAGE>



                                                                  EXHIBIT B

                                      June 23, 1995

S.P. Investors International S.A.
Steinhardt Overseas Fund Ltd.
c/o Bank of Bermuda Ltd.
Corporate Trust Services Department
129 Front Street
Hamilton 5-31
Bermuda
Attention:  Stewart Bent

Gershon Partners L.P.
Royal Trust Bank Cayman Ltd.
2nd Floor
Royal Bank of Canada Building
Cardinal Avenue
Grand Cayman, Cayman Island
Attention:  Frank Boers

            Re:  Advanced Tissue Sciences, Inc.

Ladies and Gentlemen:

            We have acted as counsel for Advanced Tissue Sciences, Inc., a 
Delaware corporation (the "Company"), in connection with the issuance and 
sale of shares of its Common Stock pursuant to those certain Investment 
Agreements dated as of June 23, 1995 (the "Purchase Agreement") by and 
between the Company and each of S.P. Investors International S.A., 
Steinhardt Overseas Fund Ltd. and Gershon Partners L.P. (collectively the 
"Purchasers").  This opinion is being rendered to you pursuant to Section 
4.2(e) of the Purchase Agreement.  Capitalized terms used herein and not
othewise defined herein shall have the meanings given to such terms in the 
Purchase Agreement.  

            In connection with the opinions expressed herein we have made 
such examination of matters of law and of fact as we considered appropriate 
or advisable for purposes hereof.  As to matters of fact material to the 
opinions expressed herein, we have relied upon the representations and 
warranties as to factual matters contained in and made by the Company 
pursuant to the Purchase Agreement and upon certificates and statements of 
government officials and of officers of the Company.  We have also examined 
originals or copies of such corporate documents or records of the Company
as we have considered appropriate for the opinions expressed herein.  We 
have assumed for the purposes of this opinion that the signatures on 
documents and instruments examined by us are authentic, that each document 
is what it purports to be, and that all documents submitted to us as copies 
conform with the originals, which facts we have not independently verified.

<PAGE>
S.P. Investors International S.A.                                 Page 2
Steinhardt Overseas Fund Ltd.
Gershon Partners L.P.
Agreement dated June 23, 1995
June 23, 1995

            In rendering this opinion we have also assumed:  (A) that the 
Purchase Agreement has been duly and validly executed and delivered by you 
or on your behalf and constitute valid, binding and enforceable obligations 
upon you; (B) that the representations and warranties made in the Purchase 
Agreement by you are true and correct; (C) that any wire transfers, drafts 
or checks tendered by you will be honored; (D) if you are a corporation or 
other entity, that you have filed any required state franchise, income
or similar taxes; and (E) that there are no extrinsic agreements or 
understandings among the parties to the Purchase Agreement that would 
modify or interpret the terms of the Purchase Agreement or the respective 
rights or obligations of the parties thereunder, other than as set forth on 
Exhibit C thereto.

            As used in this opinion, the expression "we are not aware" or 
the phrase "to our knowledge" means as to matters of fact that, based on 
the actual knowledge of individual attorneys within the firm principally 
responsible for handling current matters for the Company and after an 
examination of documents referred to herein and after inquiries of certain 
officers of the Company, we find no reason to believe that the opinions 
expressed are factually incorrect; but beyond that we have made no factual 
investigation for the purposes of rendering this opinion.  Specifically, but
without limitation, we have made no inquiries of securities holders or 
employees of the Company.

            This opinion relates solely to the general corporate laws of 
the State of Delaware and the federal law of the United States (except that 
our opinion in paragraphs 5 and 6 below also pertains to the laws of the 
State of California), and we express no opinion with respect to the effect 
or application of any other laws.  Special rulings of authorities 
administering such laws or opinions of other counsel have not been sought 
or obtained.  

            Based upon our examination of and reliance upon the foregoing 
and subject to the limitations, exceptions, qualifications and assumptions 
set forth below and except as set forth in the Purchase Agreement thereto, 
we are of the opinion that as of the date hereof:

            1.  The Company is a corporation duly organized, validly 
existing and in good standing under the laws of the State of Delaware, and 
the Company has the requisite corporate power and authority to own its 
properties and to conduct its business as presently conducted.

<PAGE>
S.P. Investors International S.A.                                 Page 3
Steinhardt Overseas Fund Ltd.
Gershon Partners L.P.
Agreement dated June 23, 1995
June 23, 1995

            2.  To our knowledge, the Company is duly qualified to do 
business as a foreign corporation and is in good standing in each 
jurisdiction where the ownership or leasing of its properties or the 
conduct of its business requires such qualification, except where the 
failure to so qualify does not have a Material Adverse Effect.  

            3.  The Company has the requisite corporate power and authority 
to execute, deliver and perform the Purchase Agreement.  The Purchase 
Agreement has been duly and validly authorized by the Company, duly executed 
and delivered by an authorized officer of the Company and constitutes a 
legal, valid and binding obligation of the Company, enforceable against the 
Company according to its terms.

            4.  The capitalization of the Company is as stated in the 
Company's Quarterly Report on Form 10-Q for the quarter ended March 31, 
1995, as amended and supplemented by Exhibit A to the Purchase Agreement 
(collectively, the "Supplemented 10-Q").  No shares of Common Stock are 
entitled to preemptive rights, and except as described in the Supplemented 
10-Q, there are no preemptive rights or, to our knowledge, options, 
warrants, conversion privileges or other rights (or agreements for any such 
rights) outstanding to purchase or otherwise obtain from the Company any
of the Company's securities.

            5.  The execution, delivery, performance and compliance with 
the terms of the Purchase Agreement do not violate any provision of any 
federal, California state or Delaware corporate law, rule or regulation 
applicable to the Company, or by which any property or asset of the Company 
is bound or affected, or the Company's Certificate or Bylaws, or conflict 
with, or constitute a default under, or give to others any rights of 
termination, amendment, acceleration or cancellation of, any agreement or 
in the Company is a party and which has been filed as a material agreement 
in the Company's Annual Report on Form 10-K for the year ended December 31, 
1994. 

            6.  All consents, approvals, permits, orders or authorizations 
of, and all qualifications, registrations, designations, declarations or 
filings with, any federal, California state or Delaware general corporate 
governmental authority on the part of the Company required in connection 
with the execution and delivery of the Purchase Agreement and consummation 
at the Closing of the transactions contemplated by the Purchase Agreement 
have been obtained, and are effective, except the additional listing 
application required to be filed with the National Association of Securities
Dealers, Inc. and the registration statement required to 

<PAGE>
S.P. Investors International S.A.                                 Page 4
Steinhardt Overseas Fund Ltd.
Gershon Partners L.P.
Agreement dated June 23, 1995
June 23, 1995

be filed with the Securities and Exchange Commission by Section 1.5 of the 
Purchase Agreement, and we are not aware of any proceedings, or threat 
thereof, that question the validity thereof.

            7.  The Shares have been duly authorized and, when issued and 
delivered to the Purchasers against payment therefor in accordance with the 
terms of the Purchase Agreement, will be validly issued, fully paid and 
non-assessable.

            8.  The Additional Shares have been authorized and reserved for 
issuance pursuant to the terms of the Purchase Agreement, and when issued 
and delivered to the Purchasers in accordance with the terms of the 
Purchase Agreement, will be validly issued, fully paid and non-assessable.

            9.  We are not aware of any action, proceeding or governmental 
investigation pending or threatened against the Company which questions the 
validity, or which affects the enforceability, of the Purchase Agreement or 
the right of the Company to enter into such Purchase Agreement or which 
would, if decided adversely to the Company, have a Material Adverse Effect.

            Our opinions expressed above are specifically subject to the 
following limitations, exceptions, qualifications and assumptions:

            (A)  For purposes of our opinions in paragraphs 5 and 6 above, 
we are rendering no opinion as to the applicability of, or the Company's 
compliance or non-compliance with, any federal, state or foreign securities 
laws as they may relate to the transactions described in the Purchase 
Agreement, the execution, delivery and performance of the Purchase Agreement 
by the Company and the consummation by the Company of the transactions 
contemplated thereby.

            (B)  The effect of bankruptcy, insolvency, reorganization, 
moratorium and other similar laws relating to or affecting the relief of 
debtors or the rights and remedies of creditors generally, including without 
limitation the effect of statutory or other law regarding fraudulent 
conveyances and preferential transfers.

            (C)  We express no opinion as to the Company's compliance or 
noncompliance with applicable federal or state antifraud or antitrust 
statutes, laws, rules and regulations.

            (D)  Limitations imposed by general equitable principles upon 
the specific enforceability of any of the remedies, covenants 

<PAGE>
S.P. Investors International S.A.                                 Page 5
Steinhardt Overseas Fund Ltd.
Gershon Partners L.P.
Agreement dated June 23, 1995
June 23, 1995

or other provisions of any applicable agreement and upon the availability of 
injunctive relief or other equitable remedies, regardless of whether 
enforcement of any such agreement is considered a proceeding in equity or 
at law.

            (E)  The unenforceability under certain circumstances of 
provisions, indemnifying a party against, or requiring contributions toward, 
that party's liability for its own wrongful or negligent acts, or where 
indemnification or contribution is contrary to public policy.  In this 
regard, we advise you that in the opinion of the Securities and Exchange 
Commission indemnification of directors, officers and controlling persons 
of an issuer against liabilities arising under the Securities Act of 1933, 
as amended, is against public policy and is therefore unenforceable.

            This opinion is rendered as of the date first written above 
solely for your benefit in connection with the Purchase Agreement and may 
not be delivered to, quoted or relied upon by any person other than you, or 
for any other purpose, without our prior written consent.  Our opinion is 
expressly limited to the matters set forth above and we render no opinion, 
whether by implication or otherwise, as to any other matters relating to 
the Company.  We assume no obligation to advise you of facts, circumstances,
events or developments which hereafter may be brought to our attention and
or developments which hereafter may be brough to our attention and which 
may alter, affect or modify the opinions expressed herein.

                                     Very truly yours,



                                     BROBECK, PHLEGER & HARRISON          
<PAGE>

                                                                   EXHIBIT C

                                      June 23, 1995

Advanced Tissue Sciences, Inc.
10933 North Torrey Pines Road
La Jolla, California 92037
Attention:  Arthur Benvenuto

Re:     Regulation S Offering

Ladies and Gentlemen:

Reference is made to the Investment Agreement of even date and delivery 
herewith (the "Agreement") between the undersigned ("Investor") and 
Advanced Tissue Sciences, Inc.  Capitalized terms contained in this letter 
shall have the same meaning ascribed to them in the Agreement.

In addition to the representations and covenants of the Investor contained 
in the Agreement, Investor further covenants and agrees as follows:

     1.    In the event the Investor engages in short sales transactions 
           or other hedging activities during the period from 105 days 
           following the Closing through 135 days following the Closing 
           which involve, among other things, sales of Common Stock of 
           the Company, Investor will, to the extent within its reasonable 
           control, conduct such activities so as not to complete or 
           effect any such sale on any trading day during such period at a 
           price which is lower than the lowest sale effected on such day 
           by persons other than the Investor;

     2.    Investor covenants that it will comply with all applicable laws, 
           rules and regulations regarding the foregoing activities and/or 
           the financing of the Shares and Additional Shares including, if 
           applicable, compliance with Regulation S.


                       [Signatures on next page.]


                                  -1-
<PAGE>
      

                                    Very truly yours,


                                    STEINHARDT OVERSEAS FUND LTD.

                                    By:  The Palladin Group, L.P., 
                                         its investment manager

                                    By:  Palladin Capital Management, LLC
                                         Its General Partner


                                    By:  /s/  Jeffrey Devers
                                        ------------------------
                                        Title:  President



                                  -2-


                                                                Exhibit 4.3

                          INVESTMENT AGREEMENT


                                 Between



                     ADVANCED TISSUE SCIENCES, INC.



                                   And


                            GERSHON PARTNERS L.P.



                          Dated as of June 23, 1995







     THE SECURITIES TO BE PURCHASED AND SOLD PURSUANT TO THIS INVESTMENT 
AGREEMENT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS 
AMENDED, (THE "ACT") OR ANY STATE SECURITIES LAWS.  THEY MAY NOT BE OFFERED 
OR SOLD IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THE 
SECURITIES UNDER SAID ACT AND ANY APPLICABLE STATE SECURITIES LAW OR AN 
APPLICABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE ACT.

<PAGE>


     INVESTMENT AGREEMENT dated as of June 23, 1995 between Gershon 
Partners L.P. (the "Investor") and Advanced Tissue Sciences, Inc., a 
corporation organized and existing under the laws of the State of 
Delaware (the "Company").

            WHEREAS, the parties desire that the Investor become an 
equity investor in the Company by purchasing an aggregate of 500,000 
shares of the Company's Common Stock, par value $.01 per share (the 
"Common Stock").

            NOW, THEREFORE, the parties hereto agree as follows:


                                ARTICLE I

                   Purchase and Sale of Common Stock
                   ---------------------------------

            Section 1.1  PURCHASE AND SALE OF COMMON STOCK.  Upon the 
terms and conditions set forth herein, the Company shall issue and sell 
to the Investor, and the Investor shall purchase from the Company, 
500,000 shares of the Company's Common Stock (the "Shares").

            Section 1.2  PURCHASE PRICE.  The aggregate purchase price 
for the Shares (the "Purchase Price") shall equal $3,430,000 payable in 
cash by wire transfer or cashier's check in immediately available funds.

            Section 1.3  SHARE NUMBER; VALUATION PERIOD.

                 (a)  The number of Shares that the Company shall be 
obligated to issue and sell and the Investor shall be obligated to 
purchase hereunder, in the aggregate, is referred to herein as the 
"Share Number."  Subject to adjustment as provided in Sections 1.3(c), 
1.3(d) and 1.3(e), the Share Number shall initially be 500,000.

                 (b)  The "Valuation Period" shall be a 45 calendar day 
period commencing on and including the first business day which is 90 
calendar days after the Closing Date (as defined herein) as the same may 
be modified pursuant to Section 4.2(c) hereof.

                 (c)  Notwithstanding Section 1.3(a) above, and except 
as hereinafter provided, if the Average Share Price (hereinafter 
defined) during the Valuation Period is less than $7.75, then the 
Company shall deliver to the Investor, at no additional cost to the 
Investor, and in addition to the initial Share Number, the number of 
shares of Common Stock that is obtained by subtracting (x) 500,000 from 
(y) the quotient obtained by dividing the Purchase Price by 88.5% of the 
Average Share Price (rounded to the nearest whole number) (together with 
any additional shares issued pursuant to Section 1.3(e) herein, the 
"Additional Shares").

                 (d)  Notwithstanding Section 1.3(a) above, and except 
as hereinafter provided, if the Average Share Price during the Valuation 
Period is greater than $7.75, the Investor shall pay to the Company the 
dollar amount by which (x) the product of 88.5% of the Average Share 
Price and the Share Number exceeds (y) the product of $6.86 and the 
Share Number.

                 (e)  Notwithstanding Section 1.3(c) above, in the event 
that the Company, on or prior to 135 days from the Closing Date, issues 
or sells any shares of its Common Stock or any 

                                  -2-
<PAGE>

of its securities which are convertible into or exchangeable for its Common 
Stock or any warrants or other rights to subscribe for or to purchase or 
any options for the purchase of, its Common Stock (other than shares or 
options issued pursuant to the Company's option plans or shares issued upon 
exercise of options, warrants or rights outstanding on the Closing Date 
or as provided on EXHIBIT A hereto), at a purchase price which is less 
than $6.86 per share (the "Subsequent Sale Price"), then the Company 
shall deliver to the Investor, at no additional cost to the Investor, 
and in addition to the Share Number, the number of shares of Common 
Stock that is obtained by subtracting (x) 500,000 from (y) the quotient 
obtained by dividing the Purchase Price by the Subsequent Sale Price 
(rounded to the nearest whole number).

                 Notwithstanding any of the foregoing, the number of 
Additional Shares issuable hereunder shall be the greater of the number 
of Additional Shares issuable pursuant to Section 1.3(c) herein and the 
number of Additional Shares issuable pursuant to Section 1.3(e) herein, 
if any.

                 (f)  For purposes hereof, the Average Share Price shall 
mean the average of the closing trading prices of the Company's Common 
Stock on the Nasdaq National Market, as reported by the Nasdaq National 
Market for each trading day during the Valuation Period.

            Section 1.4  THE CLOSING.

                 (a)  The closing of the purchase and sale of the Shares 
(the "Closing"), shall take place (a) at the offices of the Investor, at 
10:00 a.m., local time on the later of the following:  (i) June 23, 
1995, and (ii) the date on which the last to be fulfilled or waived of 
the conditions set forth in Article IV hereof and applicable to the 
Closing shall be fulfilled or waived in accordance herewith, or (b) at 
such other time and place and/or on such other date as the Investor and 
the Company may agree.  The date on which the Closing occurs is referred 
to herein as the "Closing Date."

                 (b)  (i) On the Closing Date, the Company shall deliver 
to the Investor certificates representing the Share Number to be issued 
and sold to the Investor on such date and registered in the name of the 
Investor or deposit such Share Number into the accounts designated by 
the Investor and (ii) on the Closing Date, the Investor shall deliver to 
the Company the Purchase Price by cashier's check or wire transfer in 
immediately available funds to such account as shall be designated in 
writing by the Company.  In addition, each of the Company and the 
Investor shall deliver all documents, instruments and writings required 
to be delivered by either of them pursuant to this Agreement at or prior 
to the Closing.

            Section 1.5.  COVENANT TO REGISTER.  For purposes of this 
Section 1.5, the following definitions shall apply:

                 (a)  (i)  The terms "register," "registered," and 
"registration" refer to a registration under the Act effected by 
preparing and filing a registration statement or similar document in 
compliance with the Act, and the declaration or ordering of 
effectiveness of such registration statement, document or amendment 
thereto.

                     (ii)  The term "Registrable Securities" means the 
Shares and any Additional Shares issued pursuant to Section 1.3 hereof 
and any securities of the Company or securities of any successor 
corporation issued as, or issuable upon the conversion or exercise of 
any warrant, right or other security that is issued as a dividend or 
other distribution with respect to, or in 

                                  -3-
<PAGE>

exchange for, or in replacement of, the Shares and any Additional Shares 
issued pursuant to Section 1.3 hereof.

                 (b)  (i)  The Company shall, as expeditiously as 
possible following the Closing, file a registration statement on Form S-
3 or an equivalent thereof promptly after the Closing Date, covering all 
the Registrable Securities, and shall use its best efforts to cause such 
registration statement to become effective within 105 days of the 
Closing Date (the "Initial Registration").  In the event such 
registration is not so declared effective, the holder of the Registrable 
Securities shall have the right to require by notice in writing that the 
Company register all or any part of the Registrable Securities held by 
such holder (a "Demand Registration") and the Company shall thereupon 
effect such registration in accordance herewith.  The parties agree that 
if the holder of Registrable Securities demands registration of less 
than all of the Registrable Securities, the Company, at its option, may 
nevertheless file a registration statement covering all of the 
Registrable Securities.  If such registration statement is declared 
effective with respect to all Registrable Securities the demand 
registration rights granted pursuant to this Section 1.5 (b) (i) shall 
cease.  If such registration statement is not declared effective with 
respect to all Registrable Securities the demand registration rights 
described herein shall remain in effect until all Registrable Securities 
have been registered under the Act.

                     (ii)  The Company shall not be obligated to effect 
Demand Registration (i) if all of the Registrable Securities held by the 
holder of Registrable Securities which are intended to be covered by the 
Demand Registration are, at the time of the request of a Demand 
Registration, included in an effective registration statement and the 
Company is in compliance with its obligations under Subsection (d) (ii) 
through (v) hereof.

                     (iii)  The Company may suspend the effectiveness of 
any such registration effected pursuant to this Section 1.5(b) in the 
event, and for such period of time as, such a suspension is required by 
the rules and regulations of the Securities and Exchange Commission 
("SEC").

                     (iv)  If the registration statement covering the 
Registrable Securities is not effective within 105 days of the Closing, 
then the Company shall pay the Investor a one time penalty of 1.0% of 
the Purchase Price.

                 (c)  If the Company proposes to register (including for 
this purpose a registration effected by the Company for shareholders 
other than the Investor) any of its stock or other securities under the 
Act in connection with a public offering of such securities (other than 
a registration on Form S-4, Form S-8 or other limited purpose form) and 
the Registrable Securities have not heretofore been included in a 
registration statement under Subsection (b), which remains effective, 
the Company shall, at such time, promptly give the holder of Registrable 
Securities written notice of such registration.  Upon the written 
request of the holder of Registrable Securities given within twenty (20) 
days after receipt of such notice by the holder of Registrable 
Securities, the Company shall use its best efforts to cause to be 
registered under the Act all Registrable Securities that the holder of 
Registrable Securities requests to be registered.  However, the Company 
shall have no obligation under this Subsection (c) to the extent that, 
with respect to a public offering registration, any underwriter of such 
public offering reasonably requests that the Registrable Securities or a 
portion thereof be excluded therefrom.

                 (d)  Whenever required under this Section 1.5 to effect 
the registration of any Registrable Securities, including, without 
limitation, the Initial Registration, the Company shall, as 
expeditiously as reasonably possible:

                                  -4-
<PAGE>

                     (i)  Prepare and file with the SEC a registration 
statement with respect to such Registrable Securities and use its best 
efforts to cause such registration to become effective and, upon the 
request of the Investor, keep such registration statement effective, 
pursuant to the provisions of Regulation Section 230.415 or otherwise, for so 
long as the holder of Registrable Securities desires to dispose of the 
securities covered by such registration statement (but not after the 
holder of Registrable Securities, in the reasonable opinion of its 
counsel, is free to sell such securities in any three month period under 
the provisions of Rule 144 under the Act).

                     (ii)  Prepare and file with the SEC such amendments 
and supplements to such registration statement and the prospectus used 
in connection with such registration statement as may be necessary to 
comply with the provisions of the Act with respect to the disposition of 
all securities covered by such registration statement.

                     (iii)  Furnish to the holder of Registrable 
Securities such numbers of copies of a prospectus, including a 
preliminary prospectus, in conformity with the requirements of the Act, 
and such other documents as the holder of Registrable Securities may 
reasonably require in order to facilitate the disposition of Registrable 
Securities owned by the holder of Registrable Securities.

                     (iv)  Use its best efforts to register and qualify 
the securities covered by such registration statement under such other 
securities or "Blue Sky" laws of such jurisdictions as shall be 
reasonably requested by the holder of Registrable Securities, provided 
that the Company shall not be required in connection therewith or as a 
condition thereto to qualify to do business or to file a general consent 
to service and process in any such states or jurisdictions.

                     (v)  Notify the holder of Registrable Securities of 
the happening of any event as a result of which the prospectus included 
in such registration statement, as then in effect, includes an untrue 
statement of material fact or omits to state a material fact required to 
be stated therein or necessary to make the statements therein not 
misleading in light of the circumstances then existing.

                     (vi)  Furnish, at the request of the holder of 
Registrable Securities, an opinion of counsel of the Company, dated the 
effective date of the registration statement, as to the due 
authorization and issuance of the securities being registered and 
compliance with securities laws by the Company in connection with the 
authorization and issuance thereof.

                     (vii)  Use its best efforts to list the Registrable 
Securities covered by such registration statement with any securities 
exchange on which the Common Stock is then listed;

                     (viii)  Make available for inspection by the holder 
of Registrable Securities, upon request, all SEC Documents filed 
subsequent to the Closing and require the Company's officers, directors 
and employees to supply all information reasonably requested by any 
holder of Registrable Securities in connection with such registration 
statement.

                 (e)  The holder of Registrable Securities will furnish 
to the Company in connection with any registration under this Section 
1.5 such information regarding itself, the Registrable Securities and 
other securities of the Company held by it, and the intended method of 
disposition of such securities as shall be required to effect the 
registration of the Registrable Securities held by holder of Registrable 
Securities.

                                 -5-
<PAGE>

                 (f)  (i)  The Company shall indemnify, defend and hold 
harmless each holder of Registrable Securities which are included in a 
registration statement pursuant to the provisions of Subsections (b) or 
(c) from and against, and shall reimburse such holder with respect to, 
any and all claims, suits, demands, causes of action, losses, damages, 
liabilities, costs or expenses ("Liabilities") to which such holder may 
become subject under the Act or otherwise, arising from or relating to 
(A) any untrue statement or alleged untrue statement of any material 
fact contained in such registration statement, any prospectus contained 
therein or any amendment or supplement thereto, or (B) the omission or 
alleged omission to state therein a material fact required to be stated 
therein or necessary to make the statements therein, in light of the 
circumstances in which they were made, not misleading; provided, 
however, that the Company shall not be liable in any such case to the 
extent that any such Liability arises out of or is based upon an untrue 
statement or alleged untrue statement or omission or alleged omission so 
made in conformity with information furnished by such holders in writing 
specifically for use in the preparation thereof.

                     (ii)  Promptly after receipt by the holder of 
Registrable Securities of notice of the commencement of any action, the 
holder of Registrable Securities shall, if a claim in respect thereof is 
to be made against the Company hereunder, notify the Company in writing 
thereof, but the omission so to notify the Company shall not relieve the 
Company from any Liability which it may have to the holder of 
Registrable Securities other than under this section and shall only 
relieve it from any Lability which it may have to the holder of 
Registrable Securities under this section if and to the extent the 
Company is prejudiced by such omission.  In case any such action shall 
be brought against the holder of Registrable Securities and the holder 
of Registrable Securities shall notify the Company of the commencement 
thereof, the Company shall be entitled to participate in and, to the 
extent it shall wish, to assume and undertake the defense thereof with 
counsel reasonably satisfactory to the holder of Registrable Securities, 
and, after notice from the Company to the holder of Registrable 
Securities of its election so to assume and undertake the defense 
thereof, the Company shall not be liable to the holder of Registrable 
Securities under this section for any legal expenses subsequently 
incurred by the holder of Registrable Securities in connection with the 
defense thereof other than reasonable costs of investigation and of 
liaison with counsel so selected, provided, however, that if the 
defendants in any such action include both the Company and the holder of 
Registrable Securities and the holder of Registrable Securities shall 
have reasonably concluded that there may be reasonable defenses 
available to it which are different from or additional to those 
available to the Company or if the interests of the holder of 
Registrable Securities reasonably may be deemed to conflict with the 
interests of the Company, the holder of Registrable Securities shall 
have the right to select a separate counsel and to assume such legal 
defenses and otherwise to participate in the defense of such action, 
with the expenses and fees of such separate counsel and other expenses 
related to such participation to be reimbursed by the Company as 
incurred.

                 (g)  (i)  With respect to the inclusion of Registrable 
Securities in a registration statement pursuant to subsections (b) or 
(c), all fees, costs and expenses of and incidental to such 
registration, inclusion and public offering shall be borne by the 
Company; provided, however, that any securityholders participating in 
such registration shall bear their pro rata share of the underwriting 
discounts and commissions, if any, incurred in connection with such 
registration.

                     (ii)  The fees, costs and expenses of registration 
to be borne by the Company as provided in this Subsection (g) shall 
include, without limitation, all registration, filing and NASD fees, 
printing expenses, fees and disbursements of counsel and accountants for 
the Company, and all legal fees and disbursements and other expenses of 
complying with state securities or Blue Sky laws of any jurisdiction or 
jurisdictions in which securities to be offered are to be 

                                 -6-
<PAGE>

registered and qualified.  Fees and disbursements of counsel and accountants 
for the selling securityholders shall, however, be borne by the respective 
selling securityholder.

                 (h)  (i) The rights to cause the Company to register 
all or any portion of Registrable Securities pursuant to this Section 
1.5 may be assigned by Investor to a transferee or assignee of 20% or 
more, in the aggregate, of the Shares and the Additional Shares.  Within 
a reasonable time after such transfer the Investor shall notify the 
Company of the name and address of such transferee or assignee and the 
securities with respect to which such registration rights are being 
assigned.  Such assignment shall be effective only if immediately 
following such transfer the further disposition of such securities by 
the transferee or assignee is restricted under the Act.  Any transferee 
shall agree in writing at the time of transfer to be bound by the 
provisions of this Section 1.5.

                     (ii)  From and after the date of this Agreement, 
the Company shall not agree to allow the holders of any securities of 
the Company to include any of their securities in any registration 
statement filed by the Company pursuant to Subsection (b) unless the 
inclusion of such securities will not reduce the amount of the 
Registrable Securities included therein.

            Section 1.6.  ADJUSTMENTS.  If the Investor shall be 
entitled to the issuance of Additional Shares, the Company shall deliver 
to the Investor at the offices of the Investor on the third (3rd) 
business day after the end of the Valuation Period one or more 
certificates representing the Additional Shares so to be delivered in 
accordance with this Agreement, registered in the name of the Investor, 
or deposit such Additional Shares into accounts designated by the 
Investor; provided, however, that if the sum of the shares then 
beneficially owned by the Investor, and any Additional Shares then 
issuable to the Investor, as determined by the Investor, in its sole 
determination, shall equal 1.66% or more of the shares of Company's 
Common Stock issued and outstanding (as determined in accordance with 
Section 13(d) of the Securities Exchange Act of 1934) just prior to the 
Closing, then, and in such event, (x) the number of Additional Shares to 
be issued to the Investor pursuant to this paragraph shall be reduced to 
the number which, together with the Share Number, shall equal 1.64% of 
the shares of the Company's Common Stock issued and outstanding (as so 
determined) just prior to the Closing, and (y) in consideration for such 
reduction in Additional Shares, the Company shall pay to the Investor a 
sum equal to the greater of (a) the product of 88.5% of the Average 
Share Price and the reduction in the Additional Shares to be issued as a 
result of the preceding clause (x), and (b) the product of the 
Subsequent Sale Price and the reduction in the Additional Shares to be 
issued as a result of the preceding clause (x).

            Section 1.7  RESCHEDULING.  If after the date hereof and 
prior to the expiration of the Valuation Period any person shall (a) 
publicly announce a tender offer or exchange offer for the Company's 
Common Stock, or (b) publicly announce plans for a merger, consolidation 
or potential change in control of the Company, the Investor may in its 
sole discretion elect by written notice to the Company to shorten the 
Valuation Period so as to end on a date which is either before or after 
the consummation of the record date for the consummation of any such 
transaction, which election must be made prior to consummation of any 
such transaction.  For purposes of the foregoing, it is understood and 
agreed that the Investor may, but shall not be required to, reduce or 
entirely eliminate the Valuation Period or to reschedule the Valuation 
Period.

                                  -7-
<PAGE>

                                ARTICLE II

                      Representations and Warranties
                      ------------------------------

            Section 2.1  REPRESENTATIONS AND WARRANTIES OF THE COMPANY.  
The Company hereby makes the following representations and warranties to 
the Investor:

                 (a)  ORGANIZATION AND QUALIFICATION.  The Company is a 
corporation duly incorporated and existing in good standing under the 
laws of the State of Delaware, and has the requisite corporate power to 
own its properties and to carry on its business as now being conducted.  
The Company does not have any active subsidiaries, except for those  
identified in the SEC Documents (as hereinafter defined).  Each of the 
Company and its subsidiaries is duly qualified as a foreign corporation 
to do business and is in good standing in every jurisdiction in which 
the nature of the business conducted or property owned by it makes such 
qualification necessary and where the failure so to qualify would have a 
Material Adverse Effect.  "Material Adverse Effect" means any  adverse 
effect on the operations, properties, prospects, or financial condition 
of the entity with respect to which such term is used and which is 
material to such entity and other entities controlling or controlled by 
such entity taken as a whole.

                 (b)  AUTHORIZATION; ENFORCEMENT.  (i)  The Company has 
the requisite corporate power and authority to enter into and perform 
this Agreement and to issue the Shares and the Additional Shares in 
accordance with the terms hereof, (ii) the execution and delivery of 
this Agreement by the Company and the consummation by it of the 
transactions contemplated hereby have been duly authorized by all 
necessary corporate action, and no further consent or authorization of 
the Company or its Board of Directors or stockholders is required, (iii) 
this Agreement has been duly executed and delivered by the Company, and 
(iv) this Agreement constitutes a valid and binding obligation of the 
Company enforceable against the Company in accordance with its terms, 
except as such enforceability may be limited by applicable bankruptcy, 
insolvency, reorganization, moratorium, liquidation or similar laws 
relating to, or affecting generally the enforcement of, creditors' 
rights and remedies or by other equitable principles of general 
application.

                 (c)  CAPITALIZATION.  The authorized capital stock of 
the Company  and the shares thereof currently issued and outstanding are 
as most recently described in the SEC Documents and there have been no 
changes (except for changes described on EXHIBIT A) therein since such 
description. All of the outstanding shares of the Company's Common Stock 
have been validly issued and are fully paid and nonassessable.  Except 
as set forth in EXHIBIT A hereto and as described in the SEC Documents, 
no shares of Common Stock are entitled to preemptive rights and there 
are no outstanding options, warrants, scrip, rights to subscribe to, 
calls or commitments of any character whatsoever relating to, or 
securities or rights convertible into, any shares of capital stock of 
the Company, or contracts, commitments, understandings, or arrangements 
by which the Company is or may become bound to issue additional shares 
of capital stock of the Company or options, warrants, scrip, rights to 
subscribe to, or commitments to purchase or acquire, any shares, or 
securities or rights convertible into shares, of capital stock of the 
Company.  The Company has furnished to the Investor true and correct 
copies of the Company's Certificate of Incorporation as in effect on the 
date hereof (the "Certificate"), and the Company's By-Laws, as in effect 
on the date hereof (the "By-Laws").

                 (d)  ISSUANCE OF SHARES.  The issuance of the Shares 
and Additional Shares has been duly authorized and, when paid for or 
issued in accordance with the terms hereof, shall be validly issued, 
fully paid and non-assessable.

                                  -8-
<PAGE>

                 (e)  NO CONFLICTS.  The execution, delivery and 
performance of this Agreement by the Company and the consummation by the 
Company of the transactions contemplated hereby do not and will not (i) 
result in a violation of the Company's Certificate or By-Laws or (ii) 
conflict with, or constitute a default (or an event which with notice or 
lapse of time or both would become a default) under, or give to others 
any rights of termination, amendment, acceleration or cancellation of, 
any agreement, indenture or instrument to which the Company is a party 
and which has previously been filed as an exhibit to the Company's Form 
10-K for the year ended December 31, 1994 and is still in effect, or 
result in a violation of any federal, state, local or foreign law, rule, 
regulation, order, judgment or decree (including Federal and state 
securities laws and regulations) applicable to the Company, or by which 
any property or asset of the Company is bound or affected (except for 
such conflicts, defaults, terminations, amendments, accelerations, 
cancellations and violations as would not, individually or in the 
aggregate, have a Material Adverse Effect); provided that, for purposes 
of such representation as to Federal, state, local or foreign law, rule 
or regulation, no representation is made herein with respect to any of 
the same applicable solely to the Investor and not to the Company.  The 
business of the Company is not being conducted in violation of any law, 
ordinance or regulations of any governmental entity, except for possible 
violations which either singly or in the aggregate do not have a 
Material Adverse Effect.  The Company is not required under Federal, 
state or local law, rule or regulation in the United States to obtain 
any consent, authorization or order of, or make any filing or 
registration with, any court or governmental agency in order for it to 
execute, deliver or perform any of its obligations under this Agreement 
or issue and sell the Shares or the Additional Shares in accordance with 
the terms hereof (other than the filing of a Form D with the SEC, any 
NASD filings or state securities filings which may be required to be 
made by the Company subsequent to the Closing, and any registration 
statement which may be filed in accordance with Section 1.5 herein); 
provided that, for purposes of the representation made in this sentence, 
the Company is assuming and relying upon the accuracy of the relevant 
representations and agreements of the Investor herein.

                 (f)  SEC DOCUMENTS, FINANCIAL STATEMENTS.  The Common 
Stock of the Company is registered pursuant to Section 12(g) of the 
Securities and Exchange Act of 1934, as amended (the "Exchange Act") and 
the Company has filed all reports, schedules, forms, statements and 
other documents required to be filed by it with the SEC pursuant to the 
reporting requirements of the Exchange Act, including material filed 
pursuant to Section 13(a) or 15(d), in addition to one or more 
registration statements and amendments thereto heretofore filed by the 
Company with the SEC (all of the foregoing filed prior to the date 
hereof being hereinafter referred to herein as the "SEC Documents").  
The Company has delivered to the Investor true and complete copies of 
the quarterly and annual (including, without limitation, proxy 
information and solicitation materials) SEC Documents filed with the SEC 
since December 31, 1994.  The Company has not provided to the Investor 
any information which, according to applicable law, rule or regulation, 
should have been disclosed publicly by the Company but which has not 
been so disclosed, other than with respect to the transactions 
contemplated by this Agreement.  As of their respective dates, the SEC 
Documents complied in all material respects with the requirements of the 
Exchange Act and the rules and regulations of the SEC promulgated 
thereunder and other federal, state and local laws, rules and 
regulations applicable to such SEC Documents, and none of the SEC 
Documents contained any untrue statement of a material fact or omitted 
to state a material fact required to be stated therein or necessary in 
order to make the statements therein, in light of the circumstances 
under which they were made, not misleading.  The financial statements of 
the Company included in the SEC Documents comply as to form in all 
material respects with applicable accounting requirements and the 
published rules and regulations of the SEC or other applicable rules and 
regulations with respect thereto.  Such financial statements have been 
prepared in accordance with generally accepted accounting principles 
applied on a consistent basis during the periods involved (except (i) as 
may be otherwise indicated in 

                                -9-
<PAGE>

such financial statements or the notes thereto or (ii) in the case of 
unaudited interim statements, to the extent they may not include footnotes 
or may be condensed or summary statements) and fairly present in all 
material respects the financial position of the Company as of the dates 
thereof and the results of operations and cash flows for the periods then 
ended (subject, in the case of unaudited statements, to normal year-end 
audit adjustments).

                 (g)  NO MATERIAL ADVERSE CHANGE.  Since December 31, 
1994,  the date through which the most recent annual report of the 
Company on Form 10-K has been prepared and filed with the SEC, a copy of 
which is included in the SEC Documents, no Material Adverse Effect has  
occurred or exists with respect to the Company except as otherwise 
disclosed or reflected in other SEC Documents prepared through or as of 
a date subsequent to December 31, 1994.

                 (h)  NO UNDISCLOSED LIABILITIES.  The Company has no 
liabilities or obligations not disclosed in the SEC Documents, other 
than those incurred in the ordinary course of the Company's business 
since March 31, 1995 and which, individually or in the aggregate, do not 
or would not have a Material Adverse Effect on the Company.

                 (i)  NO UNDISCLOSED EVENTS OR CIRCUMSTANCES.  No event 
or circumstance has occurred or exists with respect to the Company or 
its business, properties, prospects, operations or financial condition, 
which, under applicable law, rule or regulation, requires public 
disclosure or announcement by the Company but which has not been so 
publicly announced or disclosed.

            Section 2.2  REPRESENTATIONS AND WARRANTIES OF THE INVESTOR. 
The Investor hereby makes the following representations and warranties 
to the Company:

                 (a)  AUTHORIZATION; ENFORCEMENT.  (i)  The Investor has 
the requisite power and authority to enter into and perform this 
Agreement and to purchase the Shares being sold hereunder, (ii) the 
execution and delivery of this Agreement by the Investor and the 
consummation by it of the transactions contemplated hereby have been 
duly authorized by all necessary corporate action, and no further 
consent or authorization of the Investor or its Board of Directors, 
stockholders, or partners, as the case may be, is required, (iii) this 
Agreement has been duly authorized, executed and delivered by the 
Investor, and (iv) this Agreement constitutes a valid and binding 
obligation of the Investor enforceable against the Investor in 
accordance with its terms, except as enforceability may be limited by 
applicable bankruptcy, insolvency, reorganization, moratorium, 
liquidation or similar laws relating to, or affecting generally the 
enforcement of, creditors' rights and remedies or by other equitable 
principles of general application.

                 (b)  NO CONFLICTS.  The execution, delivery and 
performance of this Agreement and the consummation by the Investor of 
the transactions contemplated hereby or relating hereto do not and will 
not (i) result in a violation of the Investor's charter documents or By-
Laws or (ii) conflict with, or constitute a default (or an event which 
with notice or lapse of time or both would become a default) under, or 
give to others any rights of termination, amendment, acceleration or 
cancellation of any agreement, indenture or instrument to which the 
Investor is a party, or result in a violation of any law, rule, or 
regulation, or any order, judgment or decree of any court or 
governmental agency applicable to the Investor or its properties (except 
for such conflicts, defaults and violations as would not, individually  
or in the aggregate have a Material Adverse Effect on the Investor).  
The businesses of the Investor are not being conducted in violation of 
any law, ordinance or regulation of any governmental entity, except for 
possible violations which either singly or in the aggregate do not have 
a Material Adverse Effect.  The Investor is not required to obtain any 
consent, authorization or order of, or make any filing or registration 
with, any court or governmental agency in 

                                 -10-
<PAGE>

order for it to execute, deliver or perform any of its obligations under 
this Agreement or purchase the Shares or the Additional Shares in accordance 
with the terms hereof; provided that for purposes of the representation made 
in this sentence, the Investor is assuming and relying upon the accuracy of 
the relevant representations and agreements of the Company herein.

                 (c)  OWNERSHIP.  The Investor is duly organized and 
validly existing under the laws of the place hereinabove provided and is 
not a U.S. Person as defined within Regulation S under the Securities 
Act and is not purchasing the Shares for the account or benefit of a 
U.S. Person.  On the date hereof and on the Closing Date, the Investor 
is and will be, as the case may be, located outside of the United 
States.  The Investor has such knowledge and experience in financial and 
business matters that it is capable of evaluating the merits and risks 
of the investment contemplated by this Agreement.  The Investor has been 
afforded, to the satisfaction of the Investor, the opportunity to review 
the SEC Documents and obtain such additional publicly available 
information concerning the Company and its business, and to ask such 
questions and receive such answers (based upon publicly available 
information), as the Investor deems necessary to make an informed 
investment decision.

                 (d)  INVESTMENT REPRESENTATION:  The Investor is 
purchasing the Shares and, if any, the Additional Shares for investment 
purposes and not with a view towards distribution.  Investor has no 
present intention to sell the Shares or the Additional Shares and the 
Investor has no present arrangement (whether or not legally binding) at 
any time to sell the Shares or the Additional Shares to or through any 
person or entity; provided, however, except as provided in subsection 
(g) below, that by making the representations herein, the Investor does 
not agree to hold the Shares or the Additional Shares for any minimum or 
other specific term and reserves the right to dispose of the Shares or 
the Additional Shares at any time in accordance with Federal securities 
laws applicable to such disposition.

                 (e)  ACCREDITED INVESTOR:  The Investor is an 
accredited investor as defined in Regulation Section 230.501 promulgated under 
the Act.

                 (f)  RULE 144.  The Investor understands that the 
Shares and any Additional Shares must be held indefinitely unless such 
Shares or Additional Shares are subsequently registered under the Act or 
an exemption from registration is available.  The Investor has been 
advised or is aware of the provisions of Rule 144 promulgated under the 
Act.

                 (g)  Notwithstanding the foregoing, the Investor shall 
not sell (including a short sale), transfer or otherwise dispose of the 
shares, or any Additional Shares issued to such Investor, at any time 
during the 105 day period following the Closing.  Notwithstanding the 
foregoing, during the Valuation Period Investor will only transfer or 
otherwise dispose of its shares in accordance with the representations 
contained in EXHIBIT C.


                               ARTICLE III

                                Covenants
                                ---------

            Section 3.1  REGULATION S

                 (a)  Notwithstanding any of the foregoing, the Company 
acknowledges and agrees that in the event that a registration statement 
covering all of the Registrable Securities shall not have become 
effective within 105 days of the Closing Date, the legend described in 
Article V herein 

                                 -11-
<PAGE>

shall be removed on the 106th day following the Closing, in accordance with 
Article V herein, it being acknowledged by the Company that, in such event, 
the Investor shall be free to transfer, sell, pledge, or otherwise 
hypothecate the Shares and the Additional Shares issued pursuant to this 
Agreement in accordance with (a) Regulation S under the Act and (b) the 
terms and conditions described in the letter attached hereto as EXHIBIT C.

                 (b)  The Company acknowledges and agrees that, in the 
event the Investor sells, transfers, pledges or otherwise hypothecates 
the Shares or Additional Shares in accordance with Section 3.1(a) 
herein, for purposes of clarifying and specifying the applicable 
Restricted Period under Regulation S, the Investor intends to observe as 
the Restricted Period (as defined in Regulation S) for the Shares being 
delivered at the Closing the period of 40 days commencing upon the 
Closing Date and ending 40 days thereafter, and to observe as the 
Restricted Period applicable to the Additional Shares, if any, the 
period of 40 days commencing upon the date upon which the same are 
delivered to the Investor hereunder.

                 Neither the Company nor any of its affiliates has 
engaged or will engage in any "directed selling efforts" (as such term 
is defined under Regulation S) with respect to the Shares or the 
Additional Shares, and the Company and its affiliates have complied and 
will comply with the "offering restrictions" requirements of Regulation 
S.

                 (c)  In the event the Investor sells, transfers or 
otherwise disposes of the Shares or the Additional Shares in accordance 
with Section 3.1(a) herein, the Investor covenants and agrees that such 
sale, transfer or other disposition will be made in compliance with the 
terms of Regulation S under the Act, as in effect at that time, 
including (i) that the Shares and the Additional Shares will not be 
offered or sold within the United States or to, or for the account or 
benefit of, any "U.S. person" (as such term is defined in Rule 902 (o) 
promulgated under the Act) except in accordance with the provisions of 
Rule 903 or Rule 904 of Regulation S under the Securities Act, pursuant 
to registration under the Act, or pursuant to an exemption from the 
registration requirements of the Act and (ii) that neither it, its 
affiliates, nor persons acting on their behalf, have engaged or will 
engage in "directed selling efforts" (as such term is defined by 
Regulation S) with respect to the Shares or the Additional Shares and 
that each of them has complied and will comply with the "offering 
restrictions" requirements of Regulation S.


            Section 3.2  SECURITIES COMPLIANCE.

                 (a)  The Company shall notify the SEC and Nasdaq, in 
accordance with its requirements, of the transactions contemplated by 
this Agreement, and shall take all other necessary action and 
proceedings as may be required and permitted by applicable law, rule and 
regulation, including, without limitation, the filing of a Form D with 
the SEC, for the legal and valid issuance of the Shares and the 
Additional Shares to the Investor.

                 (b)  The Investor understands that the Shares and, if 
any, the Additional Shares, are being offered and sold to it in reliance 
on a transactional exemption from the registration 

                                 -12-
<PAGE>

requirements of Federal and state securities laws and that the Company is 
relying upon the truth and accuracy of the representations, warranties, 
agreements, acknowledgments and understandings of such Investor set forth 
herein in order to determine the applicability of such exemptions and the 
suitability of such Investor to acquire the Shares.

            Section 3.3  CORPORATE.  (a) From the date hereof through 
the end of the Valuation Period the Company shall not (i) amend its 
Certificate or By-Laws so as to adversely affect any rights of the 
Investor; (ii) split, combine or reclassify its outstanding capital 
stock; (iii) declare or set aside or pay any dividend or other 
distribution with respect to the Company's outstanding Common Stock; 
(iv) issue or sell, directly or indirectly, Shares of the Company's 
Common Stock in a manner or upon terms as could reasonably be expected 
to affect the market for the Common Stock materially and adversely; or 
(v) enter into any agreement with respect to the foregoing; and (vi) the 
Company shall at all times reserve and keep available, solely for 
issuance and delivery as Shares or Additional Shares hereunder, such 
shares of Common Stock as shall from time to time be issuable or 
reasonably be expected to be issuable as Shares or Additional Shares 
hereunder provided, however, that the number of shares so reserved shall 
at all times be at least 300% of the Share Number.

                 (b)  The Company will cause its Common Stock to 
continue to be registered under Sections 12(b) or 12(g) of the Exchange 
Act, will comply in all respects with its reporting and filing 
obligations under said act, will comply with all requirements related to 
any registration statement filed pursuant to Section 1.5 herein, and 
will not take any action or file any document (whether or not permitted 
by said Act or the rules thereunder) to terminate or suspend such 
registration or to terminate or suspend its reporting and filing 
obligations under said act, except as permitted herein.  The Company 
will take all action necessary to continue the listing or trading of its 
Common Stock on the Nasdaq National Market and will comply in all 
respects with the Company's reporting, filing and other obligations 
under the bylaws or rules of the NASD and Nasdaq.


                               ARTICLE IV

                               Conditions
                               ----------

            Section 4.1  CONDITIONS PRECEDENT TO THE OBLIGATION OF THE 
COMPANY TO SELL THE SHARES. The obligation hereunder of the Company to 
issue and/or sell the Shares or the Additional Shares to the Investor is 
further subject to the satisfaction, at or before the respective 
issuance and deliveries thereof, of each of the following conditions set 
forth below.  These conditions are for the Company's sole benefit and 
may be waived by the Company at any time in its sole discretion.

                 (a)  ACCURACY OF THE INVESTOR REPRESENTATIONS AND 
WARRANTIES.  The representations and warranties of the Investor shall be 
true and correct in all material respects as of the date when made and 
as of the date of such issuance and delivery as though made at that 
time.

                 (b)  PERFORMANCE BY THE INVESTOR.  The Investor shall 
have performed, satisfied and complied in all material respects with all 
covenants, agreements and conditions required by this Agreement to be 
performed, satisfied or complied with by the Investor at or prior to 
such date.

                 (c)  NO INJUNCTION.  No statute, rule, regulation, 
executive order, decree, ruling or injunction shall have been enacted, 
entered, promulgated or endorsed by any court or governmental authority 
of competent jurisdiction which  prohibits the consummation of any of 
the transactions contemplated by this Agreement.

                                 -13-
<PAGE>

            Section 4.2  CONDITIONS PRECEDENT TO THE OBLIGATION OF THE 
INVESTOR TO PURCHASE THE SHARES.  The obligation of the Investor 
hereunder to acquire and pay for the Shares is subject to the 
satisfaction, at or before the Closing of each of the following 
conditions set forth below.  These conditions are for the Investor's 
sole benefit and may be waived by the Investor at any time in its sole 
discretion.

                 (a)  ACCURACY OF THE COMPANY'S REPRESENTATIONS AND 
WARRANTIES.  The representations and warranties of the Company shall be 
true and correct in all material respects as of the date when made and 
as of the Closing Date as though made at that time (except for 
representations and warranties that speak as of a particular date).

                 (b)  PERFORMANCE BY THE COMPANY.  The Company shall 
have performed, satisfied and complied in all material respects with all 
covenants, agreements and conditions required by this Agreement to be 
performed, satisfied or complied with by the Company at or prior to the 
Closing.

                 (c)  NASDAQ.  From the date hereof to the Closing Date, 
as to the Shares to be issued and delivered on the Closing Date, trading 
in the Company's Common Stock shall not have been suspended by the SEC 
or the Nasdaq National Market (except for any suspension of trading of 
limited duration agreed to between the Company and the Nasdaq National 
Market solely to permit dissemination of material information regarding 
the Company), and trading in securities generally as reported by Nasdaq 
shall not have been suspended or limited or minimum prices shall not 
have been established on securities whose trades are reported by Nasdaq.  
Notwithstanding the foregoing sentence, in the event that at any point 
on or prior to the first day of the Valuation Period trading in the 
Common Stock is suspended by the SEC or the Nasdaq National Market, 
(i) calculation of the Average Stock Price shall be suspended for such 
period of time as trading in the Common Stock is suspended and (ii) the 
Valuation Period shall be reset so that such Valuation Period shall 
begin on the 90th calendar day following the Closing Date and shall end 
on the 45th calendar day thereafter on which quotations for the 
Company's Common Stock on the Nasdaq National Market are available.  In 
the event that the Company's Common Stock is delisted from the Nasdaq 
National Market at any time during the Valuation Period or in the event 
that trading in the Common Stock is suspended for a period of more than 
thirty (30) days subsequent to the commencement of the Valuation Period, 
(iii) the Valuation Period will be deemed to have concluded on the date 
on which the Common Stock was delisted or such trading was suspended, 
(iv) the Average Stock Price shall be calculated based on the number of 
days in such shortened Valuation Period, and (v) the Investor shall 
receive any Additional Shares owed to it pursuant to Section 1.3(c) 
herein within five (5) business days of the conclusion of the shortened 
Valuation Period.  In no event shall the Investor be required to deliver 
any shares for cancellation pursuant to Section 1.3(d) herein if the 
Common Stock is delisted from the Nasdaq National Market or if trading 
in the Common Stock is suspended for more than thirty (30) days during 
the Valuation Period or prior to the effectiveness of the Company's 
Initial Registration.

                 (d)  NO INJUNCTION.  No statute, rule, regulation, 
executive order, decree, ruling or injunction shall have been enacted, 
entered, promulgated or endorsed by any court or governmental authority 
of competent jurisdiction which prohibits the consummation of any of the 
transactions contemplated by this Agreement.

                                 -14-
<PAGE>

                 (e)  OPINION OF COUNSEL, ETC.  At the Closing the 
Investor shall have received an opinion of Brobeck Phleger & Harrison, 
counsel to the Company, in form and substance satisfactory to the 
Investor and its counsel (in substantially the form of EXHIBIT B 
hereto), and such other certificates and documents as the Investor or 
its counsel shall reasonably require incident to the Closing.


                                ARTICLE V

                            Legend on Stock
                            ---------------

            Each certificate representing the Shares issued pursuant to 
Section 1.3 shall be stamped or otherwise imprinted with a legend 
substantially in the following form:

          THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE 
          SECURITIES ACT OF 1933 OR ANY STATE SECURITIES LAWS.  
          THEY MAY NOT BE SOLD OR OFFERED FOR SALE IN THE 
          ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO 
          THE SECURITIES UNDER SAID ACT AND ANY APPLICABLE 
          STATE SECURITIES LAW OR AN APPLICABLE EXEMPTION FROM 
          THE REGISTRATION REQUIREMENTS OF THE ACT.  THIS 
          LEGEND SHALL CEASE TO HAVE ANY FORCE OR EFFECT AND 
          WILL BE REMOVED ON OCTOBER 7, 1995 UNLESS AN OPINION 
          OF COUNSEL TO THE COMPANY, IN FORM AND SUBSTANCE 
          SATISFACTORY TO THE INVESTOR AND ITS COUNSEL, IS 
          DELIVERED TO THE COMPANY'S TRANSFER AGENT, ON OR 
          PRIOR TO SUCH DATE STATING THAT REMOVAL OF THIS 
          LEGEND IS NOT PERMITTED UNDER LAW DUE TO A CHANGE IN 
          LAW SUBSEQUENT TO JUNE 23, 1995.

            Notwithstanding the foregoing, this legend shall cease to 
have any force or effect and will be removed on October 7, 1995, unless 
an opinion of counsel to the Company, in form and substance satisfactory 
to the Investor and its counsel, is delivered to the Company's transfer 
agent, on or prior to such date stating that removal of this legend is 
not permitted under law due to a change in law subsequent to the date 
hereof.

            No certificate representing Additional Shares, if any, 
required to be issued pursuant to this Agreement will bear a restrictive 
legend unless an opinion of the Company's counsel, in form and substance 
satisfactory to the Investor, has been issued to the Company's' transfer 
agent on or prior to the issuance of such Additional Shares stating that 
such a legend is required by law due to a change in law subsequent to 
the date hereof.


                               ARTICLE VI

                              Termination
                              -----------

            Section 6.1  TERMINATION BY MUTUAL CONSENT.  This Agreement 
may be terminated at any time prior to the Closing by the mutual consent 
of the Company and the Investor, by action of their respective Boards of 
Directors or other governing body.

                                 -15-
<PAGE>

            Section 6.2  OTHER TERMINATION.  This Agreement may be 
terminated by action of the Board of Directors or other governing body 
of the Investor or the Company at any time after June 23, 1995 if the 
Closing shall not have been consummated by June 23, 1995.

            Section 6.3  AUTOMATIC TERMINATION.  This Agreement shall 
automatically terminate without any further action of either party 
hereto if the Closing shall not have occurred by June 23, 1995.


                               ARTICLE VII

                              Miscellaneous
                              -------------

            Section 7.1  FEES AND EXPENSES.  Each party shall pay the 
fees and expenses of its advisers, counsel, accountants and other 
experts, if any, and all other expenses incurred by such party incident 
to the negotiation, preparation, execution, delivery and performance of 
this Agreement, provided that the Company shall pay, at the Closing, all 
attorneys' fees and expenses incurred by the Investor and Cappello 
Capital Corp., up to a maximum of $6,666, in connection with the 
preparation, negotiation, execution and delivery of this Agreement and 
the transactions contemplated hereunder.  Without limiting the 
generality of the foregoing, The Kriegsman Group shall be entitled to a 
finders fee pursuant to a separate agreement with respect thereto 
between such finder and the Company, and the Company shall be solely 
responsible for the full payment thereof and shall indemnify and hold 
harmless the Investor from and against all loss, cost, damage or expense 
arising therefrom.  The Company shall pay all stamp and other taxes and 
duties levied in connection with the issuance of the Shares or the 
Additional Shares pursuant hereto.

            Section 7.2  SPECIFIC ENFORCEMENT; CONSENT TO JURISDICTION.

                 (a)  The Company and the Investor acknowledge and agree 
that irreparable damage would occur in the event that any of the 
provisions of this Agreement were not performed in accordance with their 
specific terms or were otherwise breached.  It is accordingly agreed 
that the parties shall be entitled to an injunction or injunctions to 
prevent or cure breaches of the provisions of this Agreement and to 
enforce specifically the terms and provisions hereof, this being in 
addition to any other remedy to which either of them may be entitled by 
law or equity.

                 (b)  Each of the Company and the Investor (i) hereby 
irrevocably submits to the exclusive jurisdiction of the United States 
District Court and other courts of the United States sitting in New York 
for the purposes of any suit, action or proceeding arising out of or 
relating to this  Agreement and (ii) hereby waives, and agrees not to 
assert in any such suit, action or proceeding, any claim that it is not 
personally subject to the jurisdiction of such court, that the suit, 
action or proceeding is brought in an inconvenient forum or that the 
venue of the suit, action or proceeding is improper.  Each of the 
Company and the Investor consents to process being served in any such 
suit, action or proceeding by mailing a copy thereof to such party at 
the address in effect for notices to it under this Agreement and agrees 
that such service shall constitute good and sufficient service of 
process and notice thereof.  Nothing in this paragraph shall affect or 
limit any right to serve process in any other manner permitted by law.

            Section 7.3  ENTIRE AGREEMENT; AMENDMENTS.  This Agreement 
contains the entire understanding of the parties with respect to the 
matters covered hereby and thereby and, except as 

                                 -16-
<PAGE>

specifically set forth herein, neither the Company nor the Investor makes 
any representation, warranty, covenant or undertaking with respect to such 
matters.  No provision of this Agreement may be waived or amended other 
than by a written instrument signed by the party against whom enforcement 
of any such amendment or waiver is sought.

            Section 7.4  NOTICES.  Any notice or other communication 
required or permitted to be given hereunder shall be in writing and 
shall be effective (a) upon hand delivery or delivery by telex (with 
correct answer back received), telecopy or facsimile at the address or 
number designated below (if delivered on a business day during normal 
business hours where such notice is to be received), or the first 
business day following such delivery (if delivered other than on a 
business day during normal business hours where such notice is to be 
received) or (b) on the second business day following the date of 
mailing by express courier service, fully prepaid, addressed to such 
address, or upon actual receipt of such mailing, whichever shall first 
occur.  The addresses for such communications shall be:

            to the Company:

                             Advanced Tissue Sciences, Inc.
                             10933 North Torrey Pines Road
                             La Jolla, California 92037
                             Attn:  Chief Executive Officer

            with copies to:

                             Brobeck Phleger & Harrison
                             4675 MacArthur Court
                             Suite 1000
                             Newport Beach, California 92660
                             Attn:  Laura M. Brower, Esq.

            to the Investor:

                             Gershon Partners L.P.
                             c/o Royal Trust (Cayman Ltd.)
                             First Home Tower, 2nd Floor
                             P.O. Box 1586, Grand Cayman
                             Grand Cayman Islands, B.W.I.

            with copies to:

                             The Palladin Group, L.P.
                             40th West 57th Street
                             Suite 1500
                             New York, New York 10019
                             Attn:  Jeffrey Devers

Either party hereto may from time to time change its address for notices 
under this Section 7.4 by giving at least 10 days' written notice of 
such changed address to the other party hereto.

                                  -17-
<PAGE>

            Section 7.5  WAIVERS.  No waiver by either party of any 
default with respect to any provision, condition or requirement of this 
Agreement shall be deemed to be a continuing waiver in the future or a 
waiver of any other provision, condition or requirement hereof, nor 
shall any delay or omission of either party to exercise any right 
hereunder in any manner impair the exercise of any such right accruing 
to it thereafter.

            Section 7.6  HEADINGS.  The headings herein are for 
convenience only, do not constitute a part of this Agreement  and shall 
not be deemed to limit or affect any of the provisions hereof.

            Section 7.7  SUCCESSORS AND ASSIGNS.  This Agreement shall 
be binding upon and inure to the benefit of the parties and their 
successors and assigns.  The parties hereto may amend this Agreement 
without notice to or the consent of any third party.  Neither the 
Company nor the Investor shall assign this Agreement or any rights or 
obligations hereunder without the prior written consent of the other 
(which consent may be withheld for any reason in the sole discretion of 
the party from whom consent is sought); provided, however, that the 
Company may assign its rights and obligations hereunder to any acquirer 
of substantially all of the assets or a controlling equity interest of 
the Company.  The assignment by a party of this Agreement or any rights 
hereunder shall not affect the obligations of such party under this 
Agreement.

            Section 7.8  NO THIRD PARTY BENEFICIARIES.  This Agreement 
is intended for the benefit of the parties hereto and their respective 
permitted successors and assigns and is not for the benefit of, nor may 
any provision hereof be enforced by, any other person.

            Section 7.9  GOVERNING LAW.  This Agreement shall be 
governed by and construed and enforced in accordance with the internal 
laws of Delaware without regard to the principles of conflict of laws.

            Section 7.10  SURVIVAL. The representations and warranties 
of the Company and the Investor contained in Article II and the 
agreements and covenants set forth in Articles I and III shall survive 
the Closing.

            Section 7.11  EXECUTION.  This Agreement may be executed in 
two or more counterparts, all of which shall be considered one and the 
same agreement and shall become effective when counterparts have been 
signed by each party and delivered to the other party, it being 
understood that both parties need not sign the same counterpart.  In the 
event any signature is delivered by facsimile transmission, the party 
using such means of delivery shall cause four additional executed 
signature pages to be physically delivered to the other party within 
five days of the execution and delivery hereof.

            Section 7.12  PUBLICITY.  The Company and the Investor shall 
consult and cooperate with each other in issuing any press releases or 
otherwise making public statements with respect to the transactions 
contemplated hereby, provided the foregoing shall not interfere with the 
legal obligations of either party with respect to public disclosure; and 
provided further, that neither the Company nor the Investor shall be 
required to consult with the other if any such press release or public 
statement does not specifically name the other.


                [Remainder of page intentionally left blank.]

                                  -18-
<PAGE>



            IN WITNESS WHEREOF, the parties hereto have caused this 
Agreement to be duly executed by their respective authorized officers as 
of the date hereof.

                                       ADVANCED TISSUE SCIENCES, INC.


                                       By:  /s/  Arthur J. Benvenuto
                                           -----------------------------
                                           Name:  Arthur J. Benvenuto
                                           Its:  Chairman, President & CEO


                                       GERSHON PARTNERS L.P.

                                       By:  The Palladin Group, L.P., its 
                                            investment manager

                                            By:  Palladin Capital 
                                                 Management, LLC
                                                 Its General Partner


                                                 By:  /s/  Jeffrey Devers
                                                     ----------------------
                                                     Title:  President





                                 -19-
<PAGE>


                                                                  EXHIBIT A

                            CAPITALIZATION SUMMARY


The following table reconciles the Company's outstanding Common Stock and 
options and warrants as reported in the Company's Quarterly Report on 
Form 10-Q as of March 31, 1995 to June 13, 1995.

                                           Common         Options and
                                            Stock          Warrants
                                          Outstanding     Outstanding
                                         -------------   -------------

   Outstanding per Form 10-Q             30,570,993       4,186,957
   Options and warrants exercised           561,200        (561,200)
   Options and warrants granted                   -         125,000
   Options and warrants canceled                  -        (139,209)
                                         ----------       ---------

   Outstanding as of June 13, 1995       31,132,193       3,611,548
                                         ==========       =========


As of June 13, 1995, the Company had 1,900,462 remaining available for grant 
under its 1992 Stock Option/Stock Issuance Plan.

The Company will issue warrants to purchase 135,000 shares of Common Stock 
to the placement agents involved in this transaction on the Closing Date at 
an initial exercise price of $6.86 per share.

On January 5, 1995, the Company's Board of Directors (the "Board") adopted 
a Shareholder Rights Plan (the "Rights Plan").  Pursuant to the Rights Plan, 
the Board declared a dividend of one preferred share purchase right (the 
"Right") for each share of Common Stock outstanding on January 20, 1995.  
Each Right entitles the registered holder to purchase from the Company 
one-hundredth of a share of Series A Junior Participating Preferred Stock 
at an exercise price of $55 per one-hundredth share, subject to adjustment.

<PAGE>



                                                                   EXHIBIT B




                                      June 23, 1995

S.P. Investors International S.A.
Steinhardt Overseas Fund Ltd.
c/o Bank of Bermuda Ltd.
Corporate Trust Services Department
129 Front Street
Hamilton 5-31
Bermuda
Attention:  Stewart Bent

Gershon Partners L.P.
Royal Trust Bank Cayman Ltd.
2nd Floor
Royal Bank of Canada Building
Cardinal Avenue
Grand Cayman, Cayman Island
Attention:  Frank Boers

            Re:  Advanced Tissue Sciences, Inc.

Ladies and Gentlemen:

            We have acted as counsel for Advanced Tissue Sciences, Inc., a 
Delaware corporation (the "Company"), in connection with the issuance and 
sale of shares of its Common Stock pursuant to those certain Investment 
Agreements dated as of June 23, 1995 (the "Purchase Agreement") by and 
between the Company and each of S.P. Investors International S.A., 
Steinhardt Overseas Fund Ltd. and Gershon Partners L.P. (collectively the 
"Purchasers").  This opinion is being rendered to you pursuant to 
Section 4.2(e) of the Purchase Agreement.  Capitalized terms used herein and
not otherwise defined herein shall have the meanings given to such terms in 
the Purchase Agreement.  

            In connection with the opinions expressed herein we have made 
such examination of matters of law and of fact as we considered appropriate 
or advisable for purposes hereof.  As to matters of fact material to the 
opinions expressed herein, we have relied upon the representations and 
warranties as to factual matters contained in and made by the Company 
pursuant to the Purchase Agreement and upon certificates and statements of 
government officials and of officers of the Company.  We have also examined
originals or copies of such corporate documents or records of the Company as
we have considered appropriate for the opinions expressed herein.  We have 
assumed for the purposes of this opinion that the signatures on documents 
and instruments examined by us are authentic, that each document is what it 
purports to be, and that all documents submitted to us as copies conform 
with the originals, which facts we have not independently verified.

<PAGE>
S.P. Investors International S.A.                               Page 2
Steinhardt Overseas Fund Ltd.
Gershon Partners L.P.
Agreement dated June 23, 1995
June 23, 1995

            In rendering this opinion we have also assumed:  (A) that the 
Purchase Agreement has been duly and validly executed and delivered by you 
or on your behalf and constitute valid, binding and enforceable obligations 
upon you; (B) that the representations and warranties made in the Purchase 
Agreement by you are true and correct; (C) that any wire transfers, drafts 
or checks tendered by you will be honored; (D) if you are a corporation or 
other entity, that you have filed any required state franchise, income or
similar taxes; and (E) that there are no extrinsic agreements or 
understandings among the parties to the Purchase Agreement that would 
modify or interpret the terms of the Purchase Agreement or the respective 
rights or obligations of the parties thereunder, other than as set forth on 
Exhibit C thereto.

            As used in this opinion, the expression "we are not aware" or 
the phrase "to our knowledge" means as to matters of fact that, based on 
the actual knowledge of individual attorneys within the firm principally 
responsible for handling current matters for the Company and after an 
examination of documents referred to herein and after inquiries of certain 
officers of the Company, we find no reason to believe that the opinions 
expressed are factually incorrect; but beyond that we have made no factual 
made no inquiries of securities holders or employees of the Company.

            This opinion relates solely to the general corporate laws of the 
State of Delaware and the federal law of the United States (except that our 
opinion in paragraphs 5 and 6 below also pertains to the laws of the State 
of California), and we express no opinion with respect to the effect or 
application of any other laws.  Special rulings of authorities administering 
such laws or opinions of other counsel have not been sought or obtained.  

          Based upon our examination of and reliance upon the foregoing and 
subject to the limitations, exceptions, qualifications and assumptions set 
forth below and except as set forth in the Purchase Agreement thereto, we 
are of the opinion that as of the date hereof:

            1.  The Company is a corporation duly organized, validly 
existing and in good standing under the laws of the State of Delaware, and 
the Company has the requisite corporate power and authority to own its 
properties and to conduct its business as presently conducted.

<PAGE>
S.P. Investors International S.A.                                 Page 3
Steinhardt Overseas Fund Ltd.
Gershon Partners L.P.
Agreement dated June 23, 1995
June 23, 1995

            2.  To our knowledge, the Company is duly qualified to do 
business as a foreign corporation and is in good standing in each 
jurisdiction where the ownership or leasing of its properties or the 
conduct of its business requires such qualification, except where the 
failure to so qualify does not have a Material Adverse Effect.  

            3.  The Company has the requisite corporate power and authority 
to execute, deliver and perform the Purchase Agreement.  The Purchase 
Agreement has been duly and validly authorized by the Company, duly executed 
and delivered by an authorized officer of the Company and constitutes a 
legal, valid and binding obligation of the Company, enforceable against the 
Company according to its terms.

            4.  The capitalization of the Company is as stated in the 
Company's Quarterly Report on Form 10-Q for the quarter ended March 31, 
1995, as amended and supplemented by Exhibit A to the Purchase Agreement 
(collectively, the "Supplemented 10-Q").  No shares of Common Stock are 
entitled to preemptive rights, and except as described in the Supplemented 
10-Q, there are no preemptive rights or, to our knowledge, options, 
warrants, conversion privileges or other rights (or agreements for any such 
rights or, to our knowledge, options, warrants, conversion privileges or
other rights (or agreements for any such rights) outstanding to purchase
or otherwise obtain from the Company any of the Company's securities.

            5.  The execution, delivery, performance and compliance with 
the terms of the Purchase Agreement do not violate any provision of any 
federal, California state or Delaware corporate law, rule or regulation 
applicable to the Company, or by which any property or asset of the Company 
is bound or affected, or the Company's Certificate or Bylaws, or conflict 
with, or constitute a default under, or give to others any rights of 
termination, amendment, acceleration or cancellation of, any agreement or 
in the Company is a party and which has been filed as a material agreement 
in the Company's Annual Report on Form 10-K for the year ended 
December 31, 1994. 

            6.  All consents, approvals, permits, orders or authorizations 
of, and all qualifications, registrations, designations, declarations or 
filings with, any federal, California state or Delaware general corporate 
governmental authority on the part of the Company required in connection 
with the execution and delivery of the Purchase Agreement and consummation 
at the Closing of the transactions contemplated by the Purchase Agreement 
have been obtained, and are effective, except the additional listing application
required to be filed with the National Association of Securities Dealers, Inc.
and the registration statement required to 

<PAGE>
S.P. Investors International S.A.                                 Page 4
Steinhardt Overseas Fund Ltd.
Gershon Partners L.P.
Agreement dated June 23, 1995
June 23, 1995

be filed with the Securities and Exchange Commission by Section 1.5 of the 
Purchase Agreement, and we are not aware of any proceedings, or threat 
thereof, that question the validity thereof.

            7.  The Shares have been duly authorized and, when issued and 
delivered to the Purchasers against payment therefor in accordance with the 
terms of the Purchase Agreement, will be validly issued, fully paid and 
non-assessable.

            8.  The Additional Shares have been authorized and reserved for 
issuance pursuant to the terms of the Purchase Agreement, and when issued 
and delivered to the Purchasers in accordance with the terms of the Purchase 
Agreement, will be validly issued, fully paid and non-assessable.

            9.  We are not aware of any action, proceeding or governmental 
investigation pending or threatened against the Company which questions the 
validity, or which affects the enforceability, of the Purchase Agreement or 
the right of the Company to enter into such Purchase Agreement or which 
would, if decided adversely to the Company, have a Material Adverse Effect.

            Our opinions expressed above are specifically subject to the 
following limitations, exceptions, qualifications and assumptions:

            (A)  For purposes of our opinions in paragraphs 5 and 6 above, 
we are rendering no opinion as to the applicability of, or the Company's 
compliance or non-compliance with, any federal, state or foreign securities 
laws as they may relate to the transactions described in the Purchase 
Agreement, the execution, delivery and performance of the Purchase 
Agreement by the Company and the consummation by the Company of the 
transactions contemplated thereby.

            (B)  The effect of bankruptcy, insolvency, reorganization, 
moratorium and other similar laws relating to or affecting the relief of 
debtors or the rights and remedies of creditors generally, including 
without limitation the effect of statutory or other law regarding 
fraudulent conveyances and preferential transfers.

            (C)  We express no opinion as to the Company's compliance or 
noncompliance with applicable federal or state antifraud or antitrust 
statutes, laws, rules and regulations.

            (D)  Limitations imposed by general equitable principles upon 
the specific enforceability of any of the remedies, covenants 

<PAGE>
S.P. Investors International S.A.                                 Page 5
Steinhardt Overseas Fund Ltd.
Gershon Partners L.P.
Agreement dated June 23, 1995
June 23, 1995


or other provisions of any applicable agreement and upon the availability 
of injunctive relief or other equitable remedies, regardless of whether 
enforcement of any such agreement is considered a proceeding in equity or 
at law.

            (E)  The unenforceability under certain circumstances of 
provisions, indemnifying a party against, or requiring contributions 
toward, that party's liability for its own wrongful or negligent acts, or 
where indemnification or contribution is contrary to public policy.  
In this regard, we advise you that in the opinion of the Securities and 
Exchange Commission indemnification of directors, officers and controlling 
persons of an issuer against liabilities arising under the Securities Act 
of 1933, as amended, is against public policy and is therefore unenforceable.

            This opinion is rendered as of the date first written above 
solely for your benefit in connection with the Purchase Agreement and may 
not be delivered to, quoted or relied upon by any person other than you, or 
for any other purpose, without our prior written consent.  Our opinion is 
expressly limited to the matters set forth above and we render no opinion, 
whether by implication or otherwise, as to any other matters relating to 
the Company.  We assume no obligation to advise you of facts, circumstances,
events or developments which hereafter may be brought to our attention and
which may alter, affect or modify the opinions expressed herein.

                                     Very truly yours,



                                     BROBECK, PHLEGER & HARRISON          


<PAGE>


                                                                   EXHIBIT C



                                          June 23, 1995

Advanced Tissue Sciences, Inc.
10933 North Torrey Pines Road
La Jolla, California 92037
Attention:  Arthur Benvenuto

Re:     Regulation S Offering
        ---------------------

Ladies and Gentlemen:

Reference is made to the Investment Agreement of even date and delivery 
herewith (the "Agreement") between the undersigned ("Investor") and 
Advanced Tissue Sciences, Inc.  Capitalized terms contained in this letter 
shall have the same meaning ascribed to them in the Agreement.

In addition to the representations and covenants of the Investor contained 
in the Agreement, Investor further covenants and agrees as follows:

     1.     In the event the Investor engages in short sales transactions 
            or other hedging activities during the period from 105 days 
            following the Closing through 135 days following the Closing 
            which involve, among other things, sales of Common Stock of 
            the Company, Investor will, to the extent within its reasonable 
            control, conduct such activities so as not to complete or 
            effect any such sale on any trading day during such period at a 
            price which is lower than the lowest sale effected on such day 
            by persons other than the Investor;

     2.     Investor covenants that it will comply with all applicable 
            laws, rules and regulations regarding the foregoing activities 
            and/or the financing of the Shares and Additional Shares including, 
            if applicable, compliance with Regulation S.


                       [Signatures on next page.]

                                  -1-

<PAGE>

                                       Very truly yours,


                                       GERSHON PARTNERS L.P.

                                       By:  The Palladin Group, L.P.,
                                            its investment manager

                                       By:  Palladin Capital Management, LLC
                                            Its General Partner

                                       By:  /s/  Jeffrey Devers
                                           --------------------------
                                           Title:  President






                                                                 Exhibit 4.4

                      FORM OF WARRANT AGREEMENT
                    ADVANCED TISSUE SCIENCES, INC.
                        COMMON STOCK WARRANT
                        --------------------



THIS WARRANT AND THE SECURITIES ISSUABLE UPON THE EXERCISE HEREOF HAVE NOT 
BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED AND MAY NOT BE 
SOLD, OFFERED FOR SALE, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED 
UNLESS THERE IS AN EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT OR THE 
COMPANY RECEIVES AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT 
SUCH SALE OR TRANSFER IS EXEMPT FROM THE REGISTRATION AND PROSPECTUS 
DELIVERY REQUIREMENTS OF SUCH ACT.


          This certifies that, for good and valuable consideration, receipt of 
which is hereby acknowledged, -1- ("Holder") is entitled to purchase, subject 
to the terms and conditions of this Warrant, from Advanced Tissue Sciences, 
Inc., a Delaware corporation (the "Company"), -2- fully paid and 
nonassessable shares of the Common Stock ("Common Stock") of the Company,  in 
accordance with Section 2 during the period commencing the date hereof and 
ending at 5:00 p.m. California time, June 26, 2000 (the "Expiration Date"), 
at which time this Warrant will expire and become void unless earlier 
terminated as provided herein.  The shares of Common Stock of the Company 
for which this Warrant is exercisable as adjusted from time to time 
pursuant to the terms hereof, are hereinafter referred to as the "Shares."

           1.  EXERCISE PRICE.  The initial purchase price for the Shares is 
six dollars and eighty-six cents ($6.86) per share.  Such price shall be 
subject to adjustment pursuant to the terms hereof (such price, as adjusted 
from time to time, is hereinafter referred to as the "Exercise Price").

           2.  EXERCISE AND PAYMENT.  At any time after October 7, 1995, this 
Warrant may be exercised, in whole or in part, from time to time by the 
Holder, during the term hereof, by surrender of this Warrant and the Notice 
of Exercise annexed hereto duly completed and executed by the Holder to the 
Company at the principal executive offices of the Company, together with 
payment in the amount obtained by multiplying the Exercise Price then in 
effect by the number of Shares thereby purchased, as designated in the 
Notice of Exercise.  Payment may be in cash or by check payable to the 
order of the Company.  

           3.  DELIVERY OF STOCK CERTIFICATES.  Within a reasonable time after 
exercise, in whole or in part, of this Warrant, the Company shall issue in the 
name of and deliver to the Holder, a certificate or certificates for the 
number of fully paid and 

                                 1.

<PAGE>

nonassessable shares of Common Stock which the Holder shall have requested 
in the Notice of Exercise.  If this Warrant is exercised in part, the 
Company shall deliver to the Holder a new Warrant for the unexercised 
portion of this Warrant at the time of delivery of such stock certificate 
or certificates.

           4.  NO FRACTIONAL SHARES.  No fractional shares or scrip 
representing fractional shares will be issued upon exercise of this Warrant.  
If upon any exercise of this Warrant a fraction of a share results, the 
Company will pay the Holder the difference between the cash value of the 
fractional share and the portion of the Exercise Price allocable to the 
fractional share.

           5.  CHARGES, TAXES AND EXPENSES.  The Holder shall pay all transfer 
taxes or other incidental charges, if any, in connection with the transfer of 
the Shares purchased pursuant to the exercise hereof from the Company to the 
Holder.

           6.  LOSS, THEFT, DESTRUCTION OR MUTILATION OF WARRANT.  Upon 
receipt by the Company of evidence reasonably satisfactory to it of the loss, 
theft, destruction or mutilation of this Warrant, and in case of loss, theft 
or destruction, of indemnity or security reasonably satisfactory to the 
Company, and upon reimbursement to the Company of all reasonable expenses 
incidental thereto, and upon surrender and cancellation of this Warrant, 
if mutilated, the Company will make and deliver a new Warrant of like tenor 
and dated as of such cancellation, in lieu of this Warrant.

           7.  SATURDAYS, SUNDAYS, HOLIDAYS, ETC.  If the last or appointed 
day for the taking of any action or the expiration of any right required or 
granted herein shall be a Saturday or a Sunday or shall be a legal holiday, 
then such action may be taken or such right may be exercised on the next 
succeeding weekday which is not a legal holiday.

           8.  ADJUSTMENT OF EXERCISE PRICE AND NUMBER OF SHARES.  The number 
of and kind of securities purchasable upon exercise of this Warrant and the 
Exercise Price shall be subject to adjustment from time to time as follows:

                (a)  SUBDIVISIONS, COMBINATIONS AND OTHER ISSUANCES.  If the 
Company shall at any time after the date hereof but prior to the expiration of 
this Warrant subdivide its outstanding securities as to which purchase rights 
under this Warrant exist, by split-up or otherwise, or combine its outstanding 
securities as to which purchase rights under this Warrant exist, the number of 
Shares as to which this Warrant is exercisable as of the date of such 
subdivision, split-up or combination shall forthwith be proportionately 
increased in the case of a subdivision, or proportionately decreased in the 
case of a combination.  Appropriate adjustments shall also be made to the 
purchase price payable per share, but the aggregate purchase price payable 
for the 

                                  2.

<PAGE>

total number of Shares purchasable under this Warrant as of such date shall 
remain the same.

                (b) STOCK DIVIDEND.  If at any time after the date hereof the 
Company declares a dividend or other distribution on Common Stock payable in 
Common Stock or other securities or rights convertible into Common Stock 
("Common Stock Equivalents") without payment of any consideration by such 
holder for the additional shares of Common Stock or the Common Stock 
Equivalents (including the additional shares of Common Stock issuable upon 
exercise or conversion thereof), then the number of shares of Common Stock 
for which this Warrant may be exercised shall be increased as of the record 
date (or the date of such dividend distribution if no record date is set) 
for determining which holders of Common Stock shall be entitled to receive 
such dividend, in proportion to the increase in the number of outstanding 
shares (and shares of Common Stock issuable upon conversion of all such 
securities convertible into Common Stock) of Common Stock as a result of 
such dividend, and the Exercise Price shall be adjusted so that the 
aggregate amount payable for the purchase of all the Shares issuable 
hereunder immediately after the record date (or on the date of such 
distribution, if applicable), for such dividend shall equal the aggregate 
amount so payable immediately before such record date (or on the date of 
such distribution, if applicable).

                (c)  OTHER DISTRIBUTIONS.  If at any time after the date 
hereof the Company distributes to holders of its Common Stock, other than as 
part of its dissolution or liquidation or the winding up of its affairs, 
any shares of its capital stock, any evidence of indebtedness or any of 
its assets (other than cash, Common Stock or securities convertible into 
Common Stock), then the Company may, at its option, either (i) decrease the 
per share Exercise Price of this Warrant by an appropriate amount based 
upon the value distributed on each share of Common Stock as determined in 
good faith by the Company's Board of Directors or (ii) provide by 
resolution of the Company's Board of Directors that on exercise of this 
Warrant, the Holder hereof shall thereafter be entitled to receive, in 
addition to the shares of Common Stock otherwise receivable on exercise 
hereof, the number of shares or other securities or property which would 
have been received had this Warrant at the time been exercised.

                (d)  MERGER.  If at any time after the date hereof there shall 
be a merger or consolidation of the Company with or into another corporation 
when the Company is not the surviving corporation then the Holder shall 
thereafter be entitled to receive upon exercise of this Warrant, during the 
period specified herein and upon payment of the aggregate Exercise Price 
then in effect, the number of shares or other securities or property of the 
successor corporation resulting from such merger or consolidation, which 
would have been received by Holder for the shares of stock subject to this 
Warrant had this Warrant at such time been exercised.

                                   3.

<PAGE>

                (e)  RECLASSIFICATION, ETC.  If at any time after the date 
hereof there shall be a change or reclassification of the securities as to 
which purchase rights under this Warrant exist into the same or a different 
number of securities of any other class or classes, then the Holder shall 
thereafter be entitled to receive upon exercise of this Warrant, during the 
period specified herein and upon payment of the Exercise Price then in 
effect, the number of shares or other securities or property resulting from 
such change or reclassification, which would have been received by Holder 
for the shares of stock subject to this Warrant had this Warrant at such 
time been exercised.

                (f)  OTHER ADJUSTMENTS.  If at any time after the date hereof 
through October 7, 1995 any adjustment in the number of Shares or Purchase 
Price (as such terms are defined in the Investment Agreements defined below) 
occurs pursuant to Section 1.3 of those certain Investment Agreements of even 
date herewith between the Company and the Investors identified therein (the 
"Investment Agreements"), copies of which have been previously provided to 
the Holder, then the number of Shares for which this Warrant is exercisable 
and the Exercise Price shall be adjusted  in the same manner and on the same 
terms as set forth in Sections 1.3(c), (d) and (e) of such Investment 
Agreements.

           9.  NOTICE OF ADJUSTMENTS; NOTICES.  Whenever the Exercise Price or 
number of Shares purchasable hereunder shall be adjusted pursuant to Section 8 
hereof, the Company shall execute and deliver to the Holder a certificate 
setting forth, in reasonable detail, the event requiring the adjustment, the 
amount of the adjustment, the method by which such adjustment was calculated 
and the Exercise Price and number of shares purchasable hereunder after 
giving effect to such adjustment, and shall cause a copy of such certificate 
to be mailed (by first class mail, postage prepaid) to the Holder.

           10.  RIGHTS AS STOCKHOLDER.  Prior to exercise of this Warrant, the 
Holder shall not be entitled to any rights as a stockholder of the Company with 
respect to the Shares, including (without limitation) the right to vote such 
Shares, receive dividends or other distributions thereon, or be notified of 
stockholder meetings, and the Holder shall not be entitled to any notice or 
other communication concerning the business or affairs of the Company.  
However, in the event of any taking by the Company of a record of the holders 
of any class of securities for the purpose of determining the holders thereof 
who are entitled to receive any dividend (other than a cash dividend) or 
other distribution, any right to subscribe for, purchase or otherwise acquire 
any shares of stock of any class or any other securities or property, or to 
receive any other right, the Company shall mail to each Holder of this 
Warrant, at least 10 days prior to the date specified therein, a notice 
specifying the date on which any such record is to be taken for the purpose 
of such dividend, distribution or right, and the amount and character of 
such dividend, distribution or right. 

                                  4.

<PAGE>

           11.  RESTRICTED SECURITIES.  The Holder understands that this 
Warrant and the Shares purchasable hereunder constitute "restricted securities" 
under the federal securities laws inasmuch as they are, or will be, acquired 
from the Company in transactions not involving a public offering and 
accordingly may not, under such laws and applicable regulations, be resold 
or transferred without registration under the Securities Act of 1933, as 
amended (the "1933 Act") or an applicable exemption from such registration.  
In this connection, the Holder acknowledges that Rule 144 of the Securities 
and Exchange Commission is not now, and may not in the future be, available 
for resales of the Warrant and the Shares purchasable hereunder.  Unless 
the Shares are subsequently registered pursuant to Section 14, the Holder 
further acknowledges that the securities legend on Exhibit A to the Notice 
of Exercise attached hereto shall be placed on any Shares issued to the 
Holder upon exercise of this Warrant.

           12.  CERTIFICATION OF INVESTMENT PURPOSE.  Unless a current 
registration statement under the 1933 Act shall be in effect with respect 
to the securities to be issued upon exercise of this Warrant, the Holder 
covenants and agrees that, at the time of exercise hereof, it will deliver 
to the Company a written certification executed by the holder that the 
securities acquired by him upon exercise hereof are for the account of 
such Holder and acquired for investment purposes only and that such 
securities are not acquired with a view to, or for sale in connection with, 
any distribution thereof.

           13.  DISPOSITION OF SHARES.  Holder hereby agrees not to make any 
disposition of any Shares purchased hereunder unless and until:

                 (a)   Holder shall have notified the Company of the proposed 
disposition and provided a written summary of the terms and conditions of the 
proposed disposition;

                (b)   Holder shall have complied with all requirements of this 
Warrant applicable to the disposition of the Shares; and

                (c)   Holder shall have provided the Company with written 
assurances, in form and substance satisfactory to legal counsel of the Company, 
that (i) the proposed disposition does not require registration of the Shares 
under the 1933 Act or (ii) all appropriate action necessary for compliance 
with the registration requirements of the 1933 Act or of any exemption from 
registration available under the 1933 Act has been taken.

          The Company shall NOT be required (i) to transfer on its books any 
Shares which have been sold or transferred in violation of the provisions of 
this Section 13 or (ii) to treat as the owner of the Shares, or otherwise to 
accord voting or dividend rights to, 

                                 5.

<PAGE>

any transferee to whom the Shares have been transferred in contravention of 
the terms of this Warrant.

           14.  REGISTRATION RIGHTS.

                (a)  PIGGYBACK REGISTRATION.  If at any time the Company shall 
determine to register for its own account or the account of others under the
1933 Act any of its equity securities, other than on Form S-4 or Form S-8 or 
their then equivalents relating to equity securities to be issued solely in 
connection with any acquisition of any entity or business or equity 
securities issuable in connection with stock option or other employee 
benefit plans, the Company shall send to each Holder of Warrants or Shares, 
who is entitled to registration rights under this Section 14(a) written 
notice of such determination and, if within twenty (20) days after receipt 
of such notice, such Holder shall so request in writing (hereafter a 
"Selling Holder"), the Company shall include in such Registration Statement 
all or any part of the Shares issuable upon exercise of the Warrants (the 
"Registrable Securities") such Selling Holder requests to be registered, 
except that if, in connection with any underwritten public offering for the 
account of the Company the managing underwriter(s) thereof shall impose a 
limitation on the number of Registrable Securities which may be included 
in the Registration Statement because, in such underwriter(s)' judgment, 
such limitation is necessary to effect an orderly public distribution, then 
the Company shall be obligated to include in such Registration Statement 
only such limited portion of the Registrable Securities.  The obligations 
of the Company under this Section 14(a) may be waived by Holders holding a 
majority in interest of the Registrable Securities and shall expire after 
the Company has afforded the opportunity for the Holders to exercise 
registration rights for a period of five years from the date hereof under 
this Section 14(a).

                 (b)  OBLIGATIONS OF THE HOLDERS.  In connection with the 
registration of the Registrable Securities, the Selling Holders shall have the 
following obligations:

                      i.  It shall be a condition precedent to the obligations 
of the Company to take any action pursuant to this Agreement with respect to 
each Selling Holder that such Selling Holder shall furnish to the Company such 
information regarding itself, the Registrable Securities held by it and the 
intended method of disposition of the Registrable Securities held by it as 
shall be reasonably required to effect the registration of the Registrable 
Securities and shall execute such documents in connection with such 
registration as the Company may reasonably request.  At least fifteen (15) 
days prior to the first anticipated filing date of the Registration 
Statement, the Company shall notify each Selling Holder of the information 
the Company requires from each such Selling Holder (the "Requested 
Information") if such Selling Holder elects to have any of such Selling 
Holder's Registrable Securities included in the Registration Statement.  If 

                                 6.

<PAGE>

within five (5) business days prior to the filing date the Company has not 
received the Requested Information from an Selling Holder (a "Non-Responsive 
Holder"), then the Company may file the Registration Statement without 
including Registrable Securities of such Non-Responsive Holder;

                      ii.  Each Selling Holder by such Selling Holder's 
acceptance of the Registrable Securities agrees to cooperate with the Company 
as reasonably requested by the Company in connection with the preparation 
and filing of the Registration Statement hereunder, unless such Selling 
Holder has notified the Company in writing of such Selling Holder's election 
to exclude all of such Selling Holder's Registrable Securities from the 
Registration Statement; and

                      iii.  No Selling Holder may participate in any 
underwritten registration hereunder unless such Selling Holder (i) agrees to 
sell such Selling Holder's Registrable Securities on the basis provided in 
any underwriting arrangements approved by the Selling Holders entitled 
hereunder to approve such arrangements, (ii) completes and executes all 
questionnaires, powers of attorney, indemnities, underwriting agreements 
and other documents reasonably required under the terms of such underwriting 
arrangements, and (iii) agrees to pay its pro rata share of all underwriting 
discounts and commissions and other fees and expenses of investment bankers 
and any manager or managers of such underwriting and legal expenses of the 
underwriter applicable with respect to its Registrable Securities, in each 
case to the extent not payable by the Company pursuant to the terms of this 
Agreement.

                 (c)   EXPENSES OF REGISTRATION.  All expenses, other than 
underwriting discounts and commissions and other fees and expenses of 
investment bankers and other than brokerage commissions, incurred in 
connection with registrations, filings or qualifications pursuant to 
Section 14(a), including, without limitation, all registration, listing and 
qualifications fees, printers and accounting fees and the fees and 
disbursements of counsel for the Company, shall be borne by the Company; 
PROVIDED, HOWEVER, that the Selling Holders shall bear the fees and out-of-
pocket expenses of the any legal counsel selected by the Selling Holders in 
connection with such registration.  

                 (d) INDEMNIFICATION.  In the event any Registrable Securities 
are included in a Registration Statement under this Agreement:

                     i.  To the extent permitted by law, the Company will 
indemnify and hold harmless each Selling Holder who holds such Registrable 
Securities, the directors, if any, of such Selling Holder, the officers, if 
any, of such Selling Holder, each person, if any, who controls any Selling 
Holder within the meaning of the 1933 Act, any underwriter (as defined in the 
1933 Act) for the Selling Holders, the directors, if any, of such underwriter 
and 

                                  7.

<PAGE>

the officers, if any, of such underwriter, and each person, if any, who 
controls any such underwriter within the meaning of the 1933 Act (each, an 
"Indemnified Person"), against any losses, claims, damages, expenses or 
liabilities (joint or several) (collectively, "Claims") to which any of them 
may become subject under the 1933 Act or otherwise, insofar as such Claims 
(or actions or proceedings, whether commenced or threatened, in respect 
thereof) arise out of or are based upon any untrue statement or alleged 
untrue statement of a material fact contained in the Registration Statement 
when it first became effective, or any related final prospectus, amendment 
or supplement thereto, or the omission or alleged omission to state therein 
a material fact required to be stated therein or necessary to make the 
statements therein, in light of the circumstances under which the statements 
therein were made, not misleading (a "Violation").  The Company shall 
reimburse the Selling Holders and each such underwriter or controlling 
person, promptly as such expenses are incurred and are due and payable, for 
any legal fees or other reasonable expenses incurred by them in connection 
with investigating or defending any such Claim.  Notwithstanding anything 
to the contrary contained herein, the indemnification agreement contained 
in this Section 14(d)(i) shall not apply in such case to the extent any 
such Claim arising out of or based upon a Violation which occurs in reliance 
upon and in conformity with information furnished in writing to the Company 
by any Indemnified Person or underwriter for such Indemnified Person 
expressly for use in connection with the preparation of the Registration 
Statement or any such amendment thereof or supplement thereto, and shall 
not apply to amounts paid in settlement of any Claim if such settlement is 
effected without the prior written consent of the Company, which consent 
shall not be unreasonably withheld.  

                     ii.  In connection with any Registration Statement in 
which a Selling Holder is participating, each such Selling Holder agrees to 
indemnify and hold harmless, to the same extent and in the same manner set 
forth in Section 14(d)(i), the Company, each of its directors, each of its 
officers who signs the Registration Statement, each person, if any, who 
controls the Company within the meaning of the 1933 Act, any underwriter and 
any other stockholder selling securities pursuant to the Registration 
Statement or any of its directors or officers or any person who controls 
such stockholder or underwriter within the meaning of the 1933 Act 
(collectively and together with an Indemnified Person, an "Indemnified 
Party"), against any Claim to which any of them may become subject, 
under the 1933 Act or otherwise, insofar as such Claim arises out of or is 
based upon any Violation, in each case to the extent (and only to the 
extent) that such Violation occurs in reliance upon and in conformity with 
written information furnished to the Company by such Selling Holder 
expressly for use in connection with such Registration Statement, and such 
Selling Holder will reimburse any legal or other expenses reasonably 
incurred by them in connection with investigating or defending any such 
Claim; PROVIDED, HOWEVER, that the indemnity agreement 

                                 8.

<PAGE>

contained in this Section 14(d)(ii) shall not apply to amounts paid in 
settlement of any Claim if such settlement is effected without the prior 
written consent of such Selling Holder, which consent shall not be 
unreasonably withheld.

                     iii.  The Company shall be entitled to receive 
indemnities from underwriters, selling brokers, dealer managers and similar 
securities industry professionals participating in any distribution to the 
same extent as provided above, with respect to information such persons so 
furnished in writing by such persons expressly for inclusion in the 
Registration Statement.

                     iv.  Promptly after receipt by an Indemnified Person or 
Indemnified Party under this Section 14 of notice of the commencement of any 
action (including any governmental action), such Indemnified Person or 
Indemnified Party shall, if a Claim in respect thereof is made against any 
indemnifying party under this Section 14, deliver to the indemnifying party a 
written notice of the commencement thereof and the indemnifying party shall 
have the right to participate in, and, to the extent the indemnifying party 
so desires, jointly with any other indemnifying party similarly noticed, to 
assume control of the defense thereof with counsel mutually satisfactory to 
the indemnifying parties; PROVIDED, HOWEVER, that an Indemnified Person or 
Indemnified Party shall have the right to retain its own counsel, with the 
fees and expenses to be paid by the indemnifying party, if, in the reasonable 
opinion of counsel retained by the indemnifying party, the representation by 
such counsel of the Indemnified Person or Indemnified Party and the 
indemnifying party would be inappropriate due to actual or potential 
differing interests between such Indemnified Person or Indemnified Party 
and any other party represented by such counsel in such proceeding.  The 
Company shall pay for only one separate legal counsel for the Selling 
Holders; such legal counsel shall be selected by the Selling Holders holding 
a majority in interest of the Registrable Securities.  The failure to 
deliver written notice to the indemnifying party within a reasonable time 
of the commencement of any such action shall not relieve such indemnifying 
party of any liability to the Indemnified Person or Indemnified Party under 
this Section 14, except to the extent that the indemnifying party is 
prejudiced in its ability to defend such action.  The indemnification required 
by this Section 14 shall be made by periodic payments of the amount thereof 
during the course of the investigation or defense, as such expense, loss, 
damage or liability is incurred and is due and payable.

                (e)  CONTRIBUTION.  To the extent any indemnification by an 
indemnifying party is prohibited or limited by law, the indemnifying party 
agrees to make the maximum contribution with respect to any amounts for which 
it would otherwise be liable under Section 14 to the fullest extent permitted 
by law; PROVIDED, HOWEVER, that (a) no contribution shall be made under 
circumstances where the maker would not have been liable for indemnification 
under the fault standards set forth in 

                                 9.

<PAGE>

Section 14, (b) no seller of Registrable Securities guilty of fraudulent 
misrepresentation (within the meaning of Section 11(f) of the 1933 Act) 
shall be entitled to contribution from any seller of Registrable Securities 
who was not guilty of such fraudulent misrepresentation, and (c) contribution 
by any seller of Registrable Securities shall be limited in amount to the net 
amount of proceeds received by such seller from the sale of such Registrable 
Securities.

                 (f)  REPORTS UNDER EXCHANGE ACT.  With a view to making 
available to the Holders the benefits of Rule 144 promulgated under the 1933 
Act or any other similar rule or regulation of the SEC that may at any time 
permit the Holders to sell securities of the Company to the public without 
registration ("Rule 144"), the Company agrees to:

                      i.  make and keep public information available, as those 
terms are understood and defined in Rule 144; and

                      ii.  file with the SEC in a timely manner all reports 
and other documents required of the Company under the 1933 Act and the 
Securities Exchange Act of 1934, as amended (the "Exchange Act"); and

                      iii.  furnish to each Holder so long as such Holder owns 
Registrable Securities, promptly upon request, (i) a written statement by the 
Company that it has complied with the reporting requirements of Rule 144, 
(ii) a copy of the most recent annual or quarterly report of the Company and 
such other reports and documents so filed by the Company, and (iii) such other 
information as may be reasonably requested to permit the Holders to sell such 
securities without registration pursuant to Rule 144.

                (g)  ASSIGNMENT OF THE REGISTRATION RIGHTS.  The rights to 
have the Company register Registrable Securities pursuant to this Agreement 
shall be automatically assigned by the Holders to transferees or assignees of 
all or any portion of such securities only if:  (a) the Holder agrees in 
writing with the transferee or assignee to assign such rights, (b) the Company 
is, within a reasonable time after such transfer or assignment, furnished with 
written notice of (i) the name and address of such transferee or assignee, 
(ii) a copy of the agreement between Holder and the transferee regarding the 
assignment, and (iii) the securities with respect to which such registration 
rights are being transferred or assigned, (c) immediately following such 
transfer or assignment the further disposition of such securities by the 
transferee or assignee is restricted under the 1933 Act and applicable state 
securities laws, (d) such assignment is in accordance with and permitted by 
law and all other agreements between the transferor or assignor and the 
Company, including without limitation, stockholder's agreements, warrants 
and subscription agreements, and the transferor or assignor otherwise is 
not in material default of 

                                  10.

<PAGE>

any obligation to the Company under any such other agreement, and (d) at or 
before the time the Company received the written notice contemplated by clause 
(b) of this sentence the transferee or assignee agrees in writing with the 
Company to be bound by all of the provisions contained herein.

                (h)  TERMINATION OF REGISTRATION RIGHTS.  No Holder of 
Warrants or Shares shall be entitled to exercise any right provided for in 
this Section 14 at such time as such holder would be able to dispose of all of 
its Registrable Securities in any six (6) month period under SEC Rule 144.

          15.  MISCELLANEOUS.

                (a)  ASSIGNMENT.  This Warrant shall be binding upon and shall 
inure to the benefit of and be enforceable by the parties and their respective 
successors and permitted assigns.

                (b)  RESTRICTIONS.  By receipt of this Warrant, the Holder 
makes the same representations with respect to the acquisition of this 
Warrant as the Holder is required to make upon the exercise of this Warrant 
and acquisition of the Shares purchasable hereunder as set forth in the Form 
of Investment Letter attached as Exhibit A to the Notice of Exercise attached 
hereto.

                (c)  NOTICES.  Unless otherwise provided, any notice required 
or permitted under this Warrant shall be given in writing and shall be deemed 
effectively given upon personal delivery to the party to be notified or three 
(3) days following deposit with the United States Post Office, by registered 
or certified mail, postage prepaid and addressed to the party to be notified 
(or one (1) day following timely deposit with a reputable overnight courier 
with next day delivery instructions) at the address indicated below or at such 
other address as such party may designate by ten (10) days' advance written 
notice to the other parties.

            To Holder:          3-


            To the Company:     Advanced Tissue Sciences, Inc.
                                10933 North Torrey Pines Road
                                La Jolla, CA  92037
                                Attention:  President

            With a copy to:     Brobeck, Phleger & Harrison
                                4675 MacArthur Court, Suite 1000
                                Newport Beach, CA 92660
                                Attention:  Laura M. Brower, Esq.

                (d)  GOVERNING LAW.  This Warrant shall be governed by and 
construed under the laws of the State of California as applied to agreements 
among California residents entered into and to be performed entirely within 
California.

                                   11.

<PAGE>


                (e)  ENTIRE AGREEMENT.  This Warrant, the exhibits and 
schedules hereto, and the documents referred to herein, constitute the entire 
agreement and understanding of the parties hereto with respect to the subject 
matter hereof, and supersede all prior and contemporaneous agreements and 
understandings, whether oral or written, between the parties hereto with 
respect to the subject matter hereof.

                (f)  BINDING EFFECT.  This Warrant and the various rights and 
obligations arising hereunder shall inure to the benefit of and be binding upon 
the Company and its successors and assigns, and Holder and its successors and 
assigns.

                (g)  WAIVER; CONSENT.  This Warrant may not be changed, 
amended, terminated, augmented, rescinded or discharged (other than by 
performance), in whole or in part, except by a writing executed by the parties 
hereto, and no waiver of any of the provisions or conditions of this Warrant or 
any of the rights of a party hereto shall be effective or binding unless such 
waiver shall be in writing and signed by the party claimed to have given or 
consented thereto.

                (h)  SEVERABILITY.  If one or more provisions of this Warrant 
are held to be unenforceable under applicable law, such provision shall be 
excluded from this Warrant and the balance of the Warrant shall be 
interpreted as if such provision were so excluded and the balance shall be 
enforceable in accordance with its terms.

            IN WITNESS WHEREOF, the parties hereto have executed this Common 
Stock Warrant effective as of the date hereof.



DATED: June 26, 1995                        THE COMPANY:
                                            -----------

                                            Advanced Tissue Sciences, Inc.


                                            By:
                                               ---------------------------
                                                Arthur J. Benvenuto
                                                Chairman, President and
                                                Chief Executive Officer 


                                            HOLDER:
                                            ------



                                               ---------------------------
                                                1-
                                     
                                       12.

<PAGE>


                                NOTICE OF EXERCISE
                                ------------------


To:     ADVANCED TISSUE SCIENCES, INC.


           1.  The undersigned hereby elects to purchase ---------- shares of 
Common Stock ("Stock") of Advanced Tissue Sciences, Inc., a Delaware 
corporation (the "Company") pursuant to the terms of the attached Warrant, 
and tenders herewith payment of the purchase price pursuant to the terms of 
the Warrant.

           2.  Attached as Exhibit A is an appropriate investment 
representation letter addressed to the Company and executed by the undersigned 
as required by Section 12 of the Warrant.

           3.  Please issue certificates representing the shares of Stock 
purchased hereunder in the names and in the denominations indicated on 
Exhibit A attached hereto.

           4.  Please issue a new Warrant for the unexercised portion of the 
attached Warrant, if any, in the name of the undersigned.


Dated:
       --------------------                        -------------------------
                                                   1-


<PAGE>

                                    EXHIBIT A
                                    ----------



To:     ADVANCED TISSUE SCIENCES, INC.


          In connection with the purchase by the undersigned of ___________ 
shares of the Common Stock (the "Stock") of Advanced Tissue Sciences, Inc., a 
Delaware corporation (the "Company"), upon exercise of that certain Common 
Stock Warrant dated as of June 26, 1995 the undersigned hereby represents and 
warrants as follows:

           1.  The shares of Stock to be received by the undersigned upon 
exercise of the Warrant are being acquired for its own account, not as a 
nominee or agent, and not with a view to resale or distribution of any part 
thereof, and the undersigned has no present intention of selling, granting 
any participation in, or otherwise distributing the same.  The undersigned 
further represents that it does not have any contract, undertaking, agreement 
or arrangement with any person to sell, transfer or grant participation to 
such person or to any third person, with respect to the Stock.  The 
undersigned believes it has received all the information it considers 
necessary or appropriate for deciding whether to purchase the Stock.

           2.  The undersigned understands that the shares of Stock are 
characterized as "restricted securities" under the federal securities laws 
inasmuch as they are being acquired from the Company in transactions not 
involving a public offering and that under such laws and applicable regulations 
such securities may be resold without registration under the Securities Act of 
1933, as amended (the "Act"), only in certain limited circumstances.  In this 
connection, the undersigned represents that it is familiar with SEC Rule 144, 
as presently in effect, and understands the resale limitations imposed thereby 
and by the Act.

           3.  Without in any way limiting the representations set forth 
above, the undersigned agrees not to make any disposition of all or any 
portion of the Stock unless and until:

               (a)  There is then in effect a registration statement under 
the Act covering such proposed disposition and such disposition is made in 
accordance with such registration statement; or

               (b)  (i) The undersigned shall have notified the Company of 
the proposed disposition and shall have furnished the Company with a detailed 
statement of the circumstances surrounding the proposed disposition, and (ii) 
if requested, the undersigned shall have furnished the Company with an opinion 
of counsel, reasonably satisfactory to the Company that such disposition will 
not require registration of such shares under the Act.  The Company 

                                A-1

<PAGE>

will not require an opinion of counsel for sales made pursuant to Rule 144 
except in unusual circumstances.

           4.  The undersigned understands the instruments evidencing the 
Stock may bear the following legend:

            THIS CERTIFICATE AND THE SHARES REPRESENTED HEREBY HAVE NOT BEEN 
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED AND MAY NOT BE SOLD, 
OFFERED FOR SALE, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED UNLESS THERE 
IS AN EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT OR THE COMPANY RECEIVES 
AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH SALE OR TRANSFER 
IS EXEMPT FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS OF SUCH 
ACT.



Dated:  
        -------------------------                -------------------------------
                                                 1-






                                   A-2



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