<PAGE>
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 10-C
REPORT BY ISSUER OF SECURITIES QUOTED ON NASDAQ
INTERDEALER QUOTATION SYSTEM
FILED PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934
AND RULE 13A-17 OR 15D-17 THEREUNDER
ADVANCED TISSUE SCIENCES, INC.
------------------------------
(Exact name of issuer as specified in charter)
10933 North Torrey Pines Road, La Jolla California 92037
---------------------------------------------------------
(Address of principal executive offices)
Issuer's telephone number, including area code (619) 450-5730
--------------
I. CHANGE IN NUMBER OF SHARES OUTSTANDING
INDICATE ANY CHANGE (INCREASE OR DECREASE) OF 5% OR MORE IN THE NUMBER OF
SHARES OUTSTANDING:
1. TITLE OF SECURITY Common Stock, par value $.01 per share
--------------------------------------------------
2. NUMBER OF SHARES OUTSTANDING BEFORE THE CHANGE 31,217,656
---------------------
3. NUMBER OF SHARES OUTSTANDING AFTER THE CHANGE 33,886,088
---------------------
4. EFFECTIVE DATE OF CHANGE The shares were issued in a series of
-------------------------------------------
private placements in which the final number of shares to be issued
--------------------------------------------------------------------
was determined over valuation periods ending on January 17, 1996.
--------------------------------------------------------------------
5. METHOD OF CHANGE:
SPECIFY METHOD (SUCH AS MERGER ACQUISITION, EXCHANGE, DISTRIBUTION,
STOCK SPLIT, ACQUISITION OF STOCK FOR TREASURY, ETC.)
Issuance of shares of Common Stock in connection with a series of
--------------------------------------------------------------------
private placements.
--------------------------------------------------------------------
GIVE BRIEF DESCRIPTION OF TRANSACTION The Registrant issued an
------------------------------
aggregate of 2,614,432 shares of its Common Stock pursuant to
--------------------------------------------------------------------
Regulation D to the Securities Act of 1933.
--------------------------------------------------------------------
II. CHANGE IN NAME OF ISSUER
1. NAME PRIOR TO CHANGE Not Applicable
-----------------------------------------------
2. NAME AFTER CHANGE Not Applicable
--------------------------------------------------
3. EFFECTIVE DATE OF CHARTER AMENDMENT CHANGING NAME Not Applicable
------------------
4. DATE OF SHAREHOLDER APPROVAL OF CHANGE, IF REQUIRED Not Applicable
-----------------
DATE January 23, 1996 /s/ Arthur J. Benvenuto
------------------------ -------------------------------
Arthur J. Benvenuto
Chairman and Chief Executive Officer
