ADVANCED TISSUE SCIENCES INC
S-8, 1997-10-01
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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       As filed with the Securities and Exchange Commission on October 1, 1997
                                               Registration No. 33-___________
=============================================================================

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549
                               ----------------
                                   FORM S-8
                            REGISTRATION STATEMENT
                                     Under
                          The Securities Act of 1933
                               ----------------

                         ADVANCED TISSUE SCIENCES, INC.
             (Exact name of registrant as specified in its charter)

          DELAWARE                                       14-1701513
  (State or other jurisdiction                         (IRS Employer 
of incorporation or organization)                    Identification No.)

                         10933 NORTH TORREY PINES ROAD
                          LA JOLLA, CALIFORNIA 92037
            (Address of principal executive offices) (Zip Code)
                               ----------------

                         ADVANCED TISSUE SCIENCES, INC.
                           1997 STOCK INCENTIVE PLAN
                            (Full title of the plan)
                               ----------------

                              ARTHUR J. BENVENUTO
                     CHAIRMAN OF THE BOARD OF DIRECTORS
                         AND CHIEF EXECUTIVE OFFICER
                        ADVANCED TISSUE SCIENCES, INC.
           10933 NORTH TORREY PINES ROAD, LA JOLLA, CALIFORNIA 92037
                    (Name and address of agent for service)
                                (619) 450-5730
         (Telephone number, including area code, of agent for service)
                               ----------------

                       CALCULATION OF REGISTRATION FEE
=============================================================================
                                    Proposed       Proposed
  Title of                           Maximum        Maximum
 Securities          Amount          Offering      Aggregate      Amount of
   to be             to be           Price         Offering     Registration
 Registered       Registered(1)     per Share(2)    Price(2)       Fee(3)
 ----------       -------------     ------------   ---------    -------------

Common Stock,    7,005,642 shares    $15.8125   $47,437,500.00   $14,375.00
$0.01 par value
=============================================================================

(1)  This Registration Statement shall also cover any additional shares of
Common Stock which become issuable under the 1997 Stock Incentive Plan by
reason of any stock dividend, stock split, recapitalization or other similar
transaction effected without the receipt of consideration which results in an
increase in the number of the outstanding shares of Common Stock of Advanced
Tissue Sciences, Inc.

(2)  Calculated solely for purposes of this offering under Rule 457(h) of
the Securities Act of 1933, as amended, on the basis of the average of the
high and low selling prices per share of Common Stock of Advanced Tissue
Sciences, Inc. on September 26, 1997, as reported on the Nasdaq National 
Market.

(3)  Under General Instruction E, the Registration Fee is calculated solely
on the basis of the additional 3,000,000 shares of Common Stock authorized for
issuance under the new Plan.  The applicable filing fees have been paid for
the remaining 4,005,642 shares of Common Stock in connection with their
registration on Form S-8 Registration Statements covering the Registrant's 
predecessor stock option plan under Registration Nos. 33-50156 and 33-82310.
=============================================================================


<PAGE>


                               PART II

            INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


Item 3.  Incorporation of Documents by Reference
         ---------------------------------------

         Advanced Tissue Sciences, Inc. (the "Registrant") hereby
incorporates by reference into this Registration Statement the following
documents previously filed with the Securities and Exchange Commission (the
"SEC"):

         a.  The Registrant's Annual Report on Form 10-K for the fiscal year 
             ended December 31, 1996 dated March 26, 1997;

         b.  The Registrant's Quarterly Report on Form 10-Q for the fiscal 
             quarter ended June 30, 1997 dated August 11, 1997; and

         c.  The Registrant's Forms 8-A dated July 28, 1992 and January 6,
             1995 and filed with the SEC pursuant to Section 12 of the 
             Securities Exchange Act of 1934 (the "1934 Act"), in which 
             there is described the terms, rights and provisions applicable 
             to the Registrant's outstanding Common Stock.

         All reports and definitive proxy or information statements filed
pursuant to Section 13(a), 13(c), 14 or 15(d) of the 1934 Act after the date
of this Registration Statement and prior to the filing of a post-effective
amendment which indicates that all securities offered hereby have been sold or
which deregisters all securities then remaining unsold shall be deemed to be
incorporated by reference into this Registration Statement and to be a part
hereof from the date of filing of such documents.


Item 4.   Description of Securities
          -------------------------

          Not Applicable.


Item 5.   Interests of Named Experts and Counsel
          --------------------------------------

          Not Applicable.


Item 6.   Indemnification of Directors and Officers
          -----------------------------------------

          The Registrant's Bylaws provide that the Registrant will indemnify
its directors and may indemnify its officers, employees and other agents to
the full extent permitted by the Delaware General Corporation Law, as amended
("Delaware Law").  The Registrant believes that indemnification under its
Bylaws covers at least negligence and gross negligence by indemnified parties,
and requires the Registrant to advance litigation expenses in the case of
stockholder derivative actions or other actions if the director agrees to
repay advances if it is ultimately determined that the director is not
entitled to indemnification.

                                 II-1

<PAGE>

         The Registrant has entered into indemnification agreements with each
of its directors which provide the directors with indemnification rights.  One
significant difference between the indemnification rights provided under the
Registrant's Bylaws and those provided under the indemnification agreements is
that, under the Bylaws as construed in accordance with Delaware Law, amounts
may be paid as indemnity only if independent determinations are made in each
specific case that under the circumstances the individual claiming indemnity
meets certain specified standards of conduct.  Under the indemnification
agreements, a determination that a director has met these standards is not
required for such indemnity, although the agreements exclude indemnity for
conduct which is adjudged to be knowingly fraudulent, deliberately dishonest
or to constitute willful misconduct.  The Registrant also currently maintains
policies of insurance under which its directors and officers are insured,
within the limits and subject to the limitations of the policies, against
certain expenses in connection with the defense of actions, suits or
proceedings, and certain liabilities which might be imposed as a result of
such actions, suits or proceedings, to which they are parties by reason of
being or having been such directors or officers.

         The Registrant's Certificate of Incorporation provides that,
pursuant to Delaware Law, its directors shall not be liable for monetary
damages for breach of the director's fiduciary duty of care to the Registrant
and its stockholders.  This provision in the Certificate of Incorporation does
not eliminate the duty of care, and in appropriate circumstances, equitable
remedies such as injunction or other forms of non-monetary relief will remain
available under Delaware Law.  In addition, each director will continue to be
subject to liability for breach of the director's duty of loyalty to the
Registrant for acts or omissions not in good faith or involving intentional
misconduct, knowing violations of law, or actions leading to improper personal
benefit to the director, and for payment of dividends or approval of stock
repurchases or redemptions that are unlawful under Delaware Law.  The
provision does not affect a director's responsibilities under any other law,
such as the federal securities laws or state or federal environmental laws.


Item 7.   Exemption from Registration Claimed
          -----------------------------------

          Not Applicable.


Item 8.   Exhibits
          --------

Exhibit Number     Exhibit
- --------------     -------

      4            Instruments Defining Rights of Stockholders.  Reference is
                   made to Registrant's Forms 8-A dated July 28, 1992 and 
                   January 6, 1995 which are incorporated herein by 
                   reference pursuant to Item 3(c).
      5            Opinion and consent of Brobeck, Phleger & Harrison LLP.
     23.1          Consent of Ernst & Young LLP, Independent Auditors.
     23.2          Consent of Brobeck, Phleger & Harrison LLP is contained in 
                   Exhibit 5.
     24            Power of Attorney.  Reference is made to page II-4 of this
                   Registration Statement.
     99.1          Advanced Tissue Sciences, Inc. 1997 Stock Incentive Plan.
     99.2          Form of Stock Option Agreement.
     99.3          Form of Addendum to Stock Option Agreement re: Involuntary 
                   Termination.
     99.4          Form of Stock Issuance Agreement.
     99.5          Form of Addendum to Stock Issuance Agreement re: 
                   Involuntary Termination.
     99.6          Form of Automatic Stock Option Agreement.

                                 II-2


<PAGE>

Item 9.  Undertakings
         ------------

              A.  The undersigned Registrant hereby undertakes:  (1) to file,
during any period in which offers or sales are being made, a post-effective
amendment to this Registration Statement (i) to include any prospectus
required by Section 10(a)(3) of the Securities Act of 1933, as amended (the
"1933 Act"), (ii) to reflect in the prospectus any facts or events arising
after the effective date of this Registration Statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate,
represent a fundamental change in the information set forth in this
Registration Statement and (iii) to include any material information with
respect to the plan of distribution not previously disclosed in this
Registration Statement or any material change to such information in this
Registration Statement; provided, however, that clauses (1)(i) and (1)(ii)
shall not apply if the information required to be included in a post-effective
amendment by those paragraphs is contained in periodic reports filed by the
Registrant pursuant to Section 13 or Section 15(d) of the 1934 Act that are
incorporated by reference into this Registration Statement; (2) that for the
purpose of determining any liability under the 1933 Act each such
post-effective amendment shall be deemed to be a new registration statement
relating to the securities offered therein and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof and
(3) to remove from registration by means of a post-effective amendment any of
the securities being registered which remain unsold at the termination of the
Registrant's 1997 Stock Incentive Plan.

              B.  The undersigned Registrant hereby undertakes that, for
purposes of determining any liability under the 1933 Act, each filing of the
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
1934 Act that is incorporated by reference into this Registration Statement
shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.

              C.  Insofar as indemnification for liabilities arising under the
1933 Act may be permitted to directors, officers or controlling persons of the
Registrant pursuant to the indemnification provisions summarized in Item 6, or
otherwise, the Registrant has been advised that, in the opinion of the SEC,
such indemnification is against public policy as expressed in the 1933 Act,
and is, therefore, unenforceable.  In the event that a claim for
indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless
in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the 1933
Act and will be governed by the final adjudication of such issue.

                                 II-3

<PAGE>

                                SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, as
amended, the Registrant certifies that it has reasonable grounds to believe
that it meets all of the requirements for filing on Form S-8, and has duly
caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of La Jolla, State of
California, on this 29 day of September, 1997.

                               ADVANCED TISSUE SCIENCES, INC.



                               By:  /s/ Arthur J. Benvenuto
                                  ----------------------------------
                                  Arthur J. Benvenuto
                                  Chairman of the Board of Directors
                                  and Chief Executive Officer


                           POWER OF ATTORNEY
                           -----------------


KNOW ALL PERSONS BY THESE PRESENTS:

         That the undersigned officers and directors of Advanced Tissue
Sciences, Inc., a Delaware corporation, do hereby constitute and appoint
Arthur J. Benvenuto, Gail K. Naughton and Michael V. Swanson, and each of
them, the lawful attorneys-in-fact and agents with full power and authority to
do any and all acts and things and to execute any and all instruments which
said attorneys and agents, and any one of them, determine may be necessary or
advisable or required to enable said corporation to comply with the Securities
Act of 1933, as amended, and any rules or regulations or requirements of the
Securities and Exchange Commission in connection with this Registration
Statement.  Without limiting the generality of the foregoing power and
authority, the powers granted include the power and authority to sign the
names of the undersigned officers and directors in the capacities indicated
below to this Registration Statement, to any and all amendments, both
pre-effective and post-effective, and supplements to this Registration
Statement, and to any and all instruments or documents filed as part of or in
conjunction with this Registration Statement or amendments or supplements
thereof, and each of the undersigned hereby ratifies and confirms that all
said attorneys and agents, or any one of them, shall do or cause to be done by
virtue hereof.  This Power of Attorney may be signed in several counterparts.

         IN WITNESS WHEREOF, each of the undersigned has executed this Power
of Attorney as of the date indicated.  Pursuant to the requirements of the
Securities Act of 1933, as amended, this Registration Statement has been
signed below by the following persons in the capacities and on the dates
indicated.


Signature                      Title                       Date
- ---------                      -----                       ----

/s/ Arthur J. Benvenuto        Chairman of the Board       September 29, 1997
- ---------------------------    of Directors and Chief
Arthur J. Benvenuto            Executive Officer
                               (principal executive officer)

                                 II-4

<PAGE>


Signature                      Title                        Date
- ---------                      -----                        ----


/s/ Dr. Gail K. Naughton       President, Chief             September 29, 1997
- ---------------------------    Operating Officer and
Dr. Gail K. Naughton           Director


/s/ Michael V. Swanson         Vice President, Finance and  September 29, 1997
- ---------------------------    Administration (principal)
Michael V. Swanson             financial and accounting 
                               officer)


/s/ Jerome E. Groopman, M.D.   Director                     September 29, 1997
- ----------------------------
Jerome E. Groopman, M.D.


/s/ Jack L. Heckel             Director                     September 29, 1997
- ----------------------------
Jack L. Heckel


/s/ Ronald L. Nelson           Director                     September 29, 1997
- ----------------------------
Ronald L. Nelson


/s/ Dayton Ogden               Director                     September 29, 1997
- ----------------------------
Dayton Ogden


/s/ David S. Tappan, Jr.       Director                     September 29, 1997
- ----------------------------
David S. Tappan, Jr.


/s/ Dr. Gail R. Wilensky       Director                     September 29, 1997
- ----------------------------
Dr. Gail R. Wilensky

                                 II-5

<PAGE>




                    SECURITIES AND EXCHANGE COMMISSION

                            WASHINGTON, D.C.





                              EXHIBITS

                                 TO

                              FORM S-8

                               UNDER

                       SECURITIES ACT OF 1933


                  ADVANCED  TISSUE  SCIENCES,  INC.



<PAGE>


                            EXHIBIT INDEX
                            -------------



Exhibit
Number     Exhibit
- -------    -------

  4        Instruments Defining Rights of Stockholders.  Reference is made to
           Registrant's Form 8-A dated July 28, 1992 and January 6, 1995 
           which are incorporated herein by reference pursuant to Item 3(c).
  5        Opinion and consent of Brobeck, Phleger & Harrison LLP.
 23.1      Consent of Ernst & Young LLP, Independent Auditors.
 23.2      Consent of Brobeck, Phleger & Harrison LLP is contained in 
           Exhibit 5.
 24        Power of Attorney.  Reference is made to page II-4 of this 
           Registration Statement.
 99.1      Advanced Tissue Sciences, Inc. 1997 Stock Incentive Plan.
 99.2      Form of Stock Option Agreement.
 99.3      Form of Addendum to Stock Option Agreement re: Involuntary 
           Termination.
 99.4      Form of Stock Issuance Agreement.
 99.5      Form of Addendum to Stock Issuance Agreement re: Involuntary 
           Termination.
 99.6      Form of Automatic Stock Option Agreement.



<PAGE>


                                                                     EXHIBIT 5



           OPINION AND CONSENT OF BROBECK, PHLEGER & HARRISON LLP




                                      September 29, 1997



Advanced Tissue Sciences, Inc.
10933 North Torrey Pines Road
La Jolla, California 92037


     RE:  ADVANCED TISSUE SCIENCES, INC. (THE "COMPANY") --
          REGISTRATION STATEMENT FOR OFFERING OF 7,005,642 SHARES OF 
          COMMON STOCK
          ----------------------------------------------------------

Ladies and Gentlemen:

     We refer to your registration on Form S-8 (the "Registration Statement")
under the Securities Act of 1933, as amended, of 7,005,642 shares of Common
Stock of Advanced Tissue Sciences, Inc. (the "Company") authorized for
issuance under the Company's 1997 Stock Incentive Plan (the "Plan").  We
advise you that, in our opinion, when such shares have been issued and sold
pursuant to the applicable provisions of the Plan and in accordance with the
Registration Statement, such shares will be validly issued, fully paid and
non-assessable shares of the Company's Common Stock.

     We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement.


                                   Very truly yours,


                                   /s/ Brobeck, Phleger & Harrison LLP

                                   BROBECK, PHLEGER & HARRISON LLP


<PAGE>

                                                                  EXHIBIT 23.1


              CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS







We consent to the incorporation by reference in the Registration Statement
(Form S-8) pertaining to the 1997 Stock Incentive Plan of Advanced Tissue
Sciences, Inc. of our report dated January 24, 1997, with respect to the 
consolidated financial statements of Advanced Tissue Sciences, Inc. included 
in its Annual Report (Form 10-K) for the year ended December 31, 1996, filed
with the Securities and Exchange Commission.



San Diego, Califoria                             /s/ Ernst & Young LLP
September 26, 1997
                                                 ERNST & YOUNG LLP




<PAGE>


                                                                  EXHIBIT 23.2


    Consent of Brobeck, Phleger & Harrison LLP is contained in Exhibit 5



<PAGE>



                                                                   EXHIBIT 24


                            Power of Attorney.  
        Reference is made to page II-4 of this Registration Statement




                                                                EXHIBIT 99.1


                        ADVANCED TISSUE SCIENCES, INC
                          1997 STOCK INCENTIVE PLAN
                        -----------------------------
                       
                               ARTICLE ONE

                           GENERAL PROVISIONS
                           ------------------

     I.    PURPOSE OF THE PLAN

           This 1997 Stock Incentive Plan is intended to promote the interests
of Advanced Tissue Sciences Inc., a Delaware corporation, by providing
eligible persons with the opportunity to acquire a proprietary interest, or
otherwise increase their proprietary interest, in the Corporation as an
incentive for them to remain in the service of the Corporation.  This Plan
shall serve as the successor equity incentive program to the Corporation's
1992 Stock Option/Stock Issuance Plan.

           Capitalized terms shall have the meanings assigned to such terms 
in the attached Appendix.

     II.   STRUCTURE OF THE PLAN

           A.   The Plan shall be divided into three separate equity programs:

                -    the Discretionary Option Grant Program under which
eligible persons may, at the discretion of the Plan Administrator, be granted
options to purchase shares of Common Stock,

                -    the Stock Issuance Program under which eligible persons
may, at the discretion of the Plan Administrator, be issued shares of Common
Stock directly, either through the immediate purchase of such shares or as a
bonus for services rendered the Corporation (or any Parent or Subsidiary), and

                -    the Automatic Option Grant Program under which eligible
non-employee Board members shall automatically receive option grants at
periodic intervals to purchase shares of Common Stock.

           B.   The provisions of Articles One and Five shall apply to all 
equity programs under the Plan and shall govern the interests of all persons 
under the Plan.


<PAGE>

     III.  ADMINISTRATION OF THE PLAN

           A.    The Primary Committee shall have sole and exclusive 
authority to administer the Discretionary Option Grant and Stock Issuance 
Programs with respect to Section 16 Insiders.

           B.    Administration of the Discretionary Option Grant and Stock
Issuance Programs with respect to all other persons eligible to participate in
those programs may, at the Board's discretion, be vested in the Primary
Committee or a Secondary Committee, or the Board may retain the power to
administer those programs with respect to all such persons.  The members of
the Secondary Committee may be Board members who are Employees eligible to
receive discretionary option grants or direct stock issuances under the Plan
or any other stock option, stock appreciation, stock bonus or other stock plan
of the Corporation (or any Parent or Subsidiary).

           C.    Members of the Primary Committee or any Secondary Committee 
shall serve for such period of time as the Board may determine and may be 
removed by the Board at any time.  The Board may also at any time terminate 
the functions of any Secondary Committee and reassume all powers and authority
previously delegated to such committee.

           D.    Each Plan Administrator shall, within the scope of its
administrative functions under the Plan, have full power and authority
(subject to the provisions of the Plan) to establish such rules and
regulations as it may deem appropriate for proper administration of the
Discretionary Option Grant and Stock Issuance Programs and to make such
determinations under, and issue such interpretations of, the provisions of
such programs and any outstanding options or stock issuances thereunder as it
may deem necessary or advisable.  Decisions of the Plan Administrator within
the scope of its administrative functions under the Plan shall be final and
binding on all parties who have an interest in the Discretionary Option Grant
and Stock Issuance Programs under its jurisdiction or any option or stock
issuance thereunder.

           E.    Service on the Primary Committee or the Secondary Committee 
shall constitute service as a Board member, and members of each such 
committee shall accordingly be entitled to full indemnification and 
reimbursement as Board members for their service on such committee.  No 
member of the Primary Committee or the Secondary Committee shall be liable 
for any act or omission made in good faith with  respect to the Plan or any 
option grants or stock issuances under the Plan.

           F.    Administration of the Automatic Option Grant Program shall be
self-executing in accordance with the terms of that program, and no Plan
Administrator shall exercise any discretionary functions with respect to any
option grants or stock issuances made under such program.

                                  -2-

<PAGE>

      IV.  ELIGIBILITY

           A.    The persons eligible to participate in the Discretionary 
Option Grant and Stock Issuance Programs are as follows:

                      (i)    employees,

                      (ii)   non-employee members of the Board or the board 
of directors of any Parent or Subsidiary, and

                      (iii)  consultants and other independent advisors who 
provide services to the Corporation (or any Parent or Subsidiary).

           B.    Each Plan Administrator shall, within the scope of its
administrative jurisdiction under the Plan, have full authority to determine,
(i) with respect to the option grants under the Discretionary Option Grant
Program, which eligible persons are to receive option grants, the time or
times when such option grants are to be made, the number of shares to be
covered by each such grant, the status of the granted option as either an
Incentive Option or a Non-Statutory Option, the time or times when each option
is to become exercisable, the vesting schedule (if any) applicable to the
option shares and the maximum term for which the option is to remain
outstanding and (ii) with respect to stock issuances under the Stock Issuance
Program, which eligible persons are to receive stock issuances, the time or
times when such issuances are to be made, the number of shares to be issued to
each Participant, the vesting schedule (if any) applicable to the issued
shares and the consideration for such shares.

           C.    The Plan Administrator shall have the absolute discretion
either to grant options in accordance with the Discretionary Option Grant
Program or to effect stock issuances in accordance with the Stock Issuance
Program.

           D.    The individuals who shall be eligible to participate in the
Automatic Option Grant Program shall be limited to (i) those individuals who
first become non-employee Board members on or after the Plan Effective Date,
whether through appointment by the Board or election by the Corporation's
stockholders, and (ii) those individuals who continue to serve as non-employee
Board members at one or more Annual Stockholders Meetings held on or after the
Plan Effective Date.

                                  -3-


<PAGE>

     V.    STOCK SUBJECT TO THE PLAN

           A.    The stock issuable under the Plan shall be shares of 
authorized but unissued or reacquired Common Stock, including shares 
repurchased by the Corporation on the open market.  The maximum number of
shares of Common Stock initially reserved for issuance over the term of the 
Plan shall not exceed 7,016,547 shares.  Such authorized share reserve is 
comprised of (i) the number of shares which remain available for issuance, as 
of the Plan Effective Date, under the Predecessor Plan as last approved by 
the Corporation's stockholders (estimated to be 4,016,547 shares in the 
aggregate as of March 31, 1997, including the shares subject to the 
outstanding options to be incorporated into the Plan), and (ii) an increase 
of 3,000,000 shares, adopted by the Board in March 1997 and approved by the 
Corporation's stockholders at the 1997 Annual Meeting.

           B.    No one person participating in the Plan may receive options,
separately exercisable stock appreciation rights and direct stock issuances
for more than 750,000 shares of Common Stock in the aggregate per calendar
year, beginning with the 1997 calendar year.

           C.    Shares of Common Stock subject to outstanding options 
(including options incorporated into this Plan from the Predecessor Plan) 
shall be available for subsequent issuance under the Plan to the extent those 
options expire or terminate for any reason prior to exercise in full.  
Unvested shares issued under the Plan and subsequently cancelled or 
repurchased by the Corporation, at the original exercise or issue price paid 
per share, pursuant to the Corporation's repurchase rights under the Plan 
shall be added back to the number of shares of Common Stock reserved for 
issuance under the Plan and shall accordingly be available for reissuance 
through one or more subsequent option grants or direct stock issuances under 
the Plan.  However, should the exercise price of an option under the Plan be 
paid with shares of Common Stock or should shares of Common Stock otherwise 
issuable under the Plan be withheld by the Corporation in satisfaction of the
withholding taxes incurred in connection with the exercise of an option or 
the vesting of a stock issuance under the Plan, then the number of shares of 
Common Stock available for issuance under the Plan shall be reduced by the 
gross number of shares for which the option is exercised or which vest under 
the stock issuance, and not by the net number of shares of Common Stock 
issued to the holder of such option or stock issuance.

           D.    If any change is made to the Common Stock by reason of any 
stock split, stock dividend, recapitalization, combination of shares, 
exchange of shares or other change affecting the outstanding Common Stock as 
a class without the Corporation's receipt of consideration, appropriate 
adjustments shall be made to (i) the maximum number and/or class of 
securities issuable under the Plan, (ii) the number and/or class of 
securities for which any one person may be granted stock options, separately 
exercisable stock appreciation rights and direct stock issuances under this 
Plan per calendar year, (iii) the number and/or class of securities for which
grants are subsequently to be made under the Automatic Option Grant Program 
to new and continuing non-employee Board members, (iv) the number and/or 
class of securities and the exercise price per share in effect under each 
outstanding option under the Plan and (v) the number and/or class of 

                                   -4-

<PAGE>

securities and price per share in effect under each outstanding option 
incorporated into this Plan from the Predecessor Plan.  Such adjustments to  
the outstanding options are to be effected in a manner which shall preclude 
the enlargement or dilution of rights and benefits under such options.  The 
adjustments determined by the Plan Administrator shall be final, binding and
conclusive.

                                   -5-

<PAGE>

                                ARTICLE TWO

                     DISCRETIONARY OPTION GRANT PROGRAM
                     ----------------------------------        

     I.    OPTION TERMS

           Each option shall be evidenced by one or more documents in the form
approved by the Plan Administrator; provided, however, that each such document
shall comply with the terms specified below.  Each document evidencing an
Incentive Option shall, in addition, be subject to the provisions of the Plan
applicable to such options.

           A.    EXERCISE PRICE.

                 1.   The exercise price per share shall be fixed by the Plan
Administrator but shall not be less than one hundred percent (100%) of the
Fair Market Value per share of Common Stock on the option grant date.

                 2.   The exercise price shall become immediately due upon 
exercise of the option and shall, subject to the provisions of Section I of 
Article Five and the documents evidencing the option, be payable in one or 
more of the forms specified below:

                      (i)    cash or check made payable to the Corporation,

                      (ii)   shares of Common Stock held for the requisite 
     period necessary to avoid a charge to the Corporation's earnings for 
     financial reporting purposes and valued at Fair Market Value on the 
     Exercise Date, or

                      (iii)  to the extent the option is exercised for vested
     shares, through a special sale and remittance procedure pursuant to 
     which the Optionee shall concurrently provide irrevocable instructions  
     to (a) a Corporation-designated brokerage firm to effect the immediate 
     sale of the purchased shares and remit to the Corporation, out of the 
     sale proceeds available on the settlement date, sufficient funds to 
     cover the aggregate exercise price payable for the purchased shares plus
     all applicable Federal, state and local income and employment taxes 
     required to be withheld by the Corporation by reason of such exercise 
     and (b) the Corporation to deliver the certificates for the purchased 
     shares directly to such brokerage firm in order to complete the sale.

           Except to the extent such sale and remittance procedure is utilized,
payment of the exercise price for the purchased shares must be made on the
Exercise Date.

                                   -6-


<PAGE>

           B.    EXERCISE AND TERM OF OPTIONS.   Each option shall be
exercisable at such time or times, during such period and for such number of
shares as shall be determined by the Plan Administrator and set forth in the
documents evidencing the option.  However, no option shall have a term in
excess of ten (10) years measured from the option grant date.

           C.    EFFECT OF TERMINATION OF SERVICE.

                 1.   The following provisions shall govern the exercise of
any options held by the Optionee at the time of cessation of Service or death:

                      (i)    Any option outstanding at the time of the 
     Optionee's cessation of Service for any reason shall remain exercisable
     for such period of time thereafter as shall be determined by the Plan 
     Administrator and set forth in the documents evidencing the option, but 
     no such option shall be exercisable after the expiration of the option
     term.

                      (ii)   Any option exercisable in whole or in part by 
     the Optionee at the time of death may be subsequently exercised by the 
     personal representative of the Optionee's estate or by the person or 
     persons to whom the option is transferred pursuant to the Optionee's 
     will or in accordance with the laws of descent and distribution.

                      (iii)  During the applicable post-Service exercise 
     period, the option may not be exercised in the aggregate for more than 
     the number of vested shares for which the option is exercisable on the 
     date of the Optionee's cessation of Service.  Upon the expiration of the
     applicable exercise period or (if earlier) upon the expiration of the 
     option term, the option shall terminate and cease to be outstanding for 
     any vested shares for which the option has not been exercised.  However,
     the option shall, immediately upon the Optionee's cessation of Service, 
     terminate and cease to be outstanding to the extent the option is not 
     otherwise at that time exercisable for vested shares.

                      (iv)   Should the Optionee's Service be terminated for 
     Misconduct, then all outstanding options held by the Optionee shall 
     terminate immediately and cease to be outstanding.

           2.    The Plan Administrator shall have complete discretion,
exercisable either at the time an option is granted or at any time while the
option remains outstanding, to:

                                   -7-


<PAGE>

                      (i)    extend the period of time for which the option is
     to remain exercisable following the Optionee's cessation of Service from
     the limited exercise period otherwise in effect for that option to such 
     greater period of time as the Plan Administrator shall deem appropriate, 
     but in no event beyond the expiration of the option term, and/or

                      (ii)   permit the option to be exercised, during the
     applicable post-Service exercise period, not only with respect to the 
     number of vested shares of Common Stock for which such option is 
     exercisable at the time of the Optionee's cessation of Service but also 
     with respect to one or more additional installments in which the 
     Optionee would have vested had the Optionee continued in Service.

           D.    STOCKHOLDER RIGHTS.  The holder of an option shall have no
stockholder rights with respect to the shares subject to the option until such
person shall have exercised the option, paid the exercise price and become a
holder of record of the purchased shares.

           E.    REPURCHASE RIGHTS.  The Plan Administrator shall have the
discretion to grant options which are exercisable for unvested shares of
Common Stock.  Should the Optionee cease Service while holding such unvested
shares, the Corporation shall have the right to repurchase, at the exercise
price paid per share, any or all of those unvested shares.  The terms upon
which such repurchase right shall be exercisable (including the period and
procedure for exercise and the appropriate vesting schedule for the purchased
shares) shall be established by the Plan Administrator and set forth in the
document evidencing such repurchase right.

           F.    LIMITED TRANSFERABILITY OF OPTIONS.  During the lifetime of 
the Optionee, Incentive Options shall be exercisable only by the Optionee and
shall not be assignable or transferable other than by will or by the laws of
descent and distribution following the Optionee's death.  However, a
Non-Statutory Option may, in connection with the Optionee's estate plan, be
assigned in whole or in part during the Optionee's lifetime to one or more
members of the Optionee's immediate family or to a trust established
exclusively for one or more such family members.  The assigned portion may
only be exercised by the person or persons who acquire a proprietary interest
in the option pursuant to the assignment. The terms applicable to the assigned
portion  shall  be the same as those in effect for the option immediately
prior to such assignment and shall be set forth in such documents issued to
the assignee as the Plan Administrator may deem appropriate.

                                  -8-


<PAGE>

     II.   INCENTIVE OPTIONS

           The terms specified below shall be applicable to all Incentive
Options.  Except as modified by the provisions of this Section II, all the
provisions of Articles One, Two and Five shall be applicable to Incentive
Options.  Options which are specifically designated as Non-Statutory Options
when issued under the Plan shall not be subject to the terms of this Section
II.

           A.    ELIGIBILITY.  Incentive Options may only be granted to
Employees.

           B.    EXERCISE PRICE.  The exercise price per share shall not be
less than one hundred percent (100%) of the Fair Market Value per share of
Common Stock on the option grant date.

           C.    DOLLAR LIMITATION.  The aggregate Fair Market Value of the
shares of Common Stock (determined as of the respective date or dates of
grant) for which one or more options granted to any Employee under the Plan
(or any other option plan of the Corporation or any Parent or Subsidiary) may
for the first time become exercisable as Incentive Options during any one
calendar year shall not exceed the sum of One Hundred Thousand Dollars
($100,000).  To the extent the Employee holds two (2) or more such options
which become exercisable for the first time in the same calendar year, the
foregoing limitation on the exercisability of such options as Incentive
Options shall be applied on the basis of the order in which such options are
granted.

           D.    10% STOCKHOLDER.  If any Employee to whom an Incentive Option
is granted is a 10% Stockholder, then the exercise price per share shall not
be less than one hundred ten percent (110%) of the Fair Market Value per share
of Common Stock on the option grant date, and the option term shall not exceed
five (5) years measured from the option grant date.

     III.  CORPORATE TRANSACTION/CHANGE IN CONTROL

           A.    In the event of any Corporate Transaction, each outstanding
option shall automatically accelerate so that each such option shall,
immediately prior to the effective date of the Corporate Transaction, become
fully exercisable with respect to the total number of shares of Common Stock
at the time subject to such option and may be exercised for any or all of
those shares as fully-vested shares of Common Stock.  However, an outstanding
option shall not so accelerate if and to the extent:  (i) such option is, in
connection with the Corporate Transaction, to be assumed by the successor
corporation (or parent thereof), (ii) such option is to be replaced with a
cash incentive program of the successor corporation which preserves the spread
existing on the unvested option shares at the time of the Corporate
Transaction and provides for subsequent payout in accordance with the same
vesting schedule applicable to those option shares or (iii) the acceleration
of such option is subject to other limitations imposed by the Plan
Administrator at the time of the option grant.

                                  -9-

<PAGE>


           B.    All outstanding repurchase rights shall also terminate
automatically, and the shares of Common Stock subject to those terminated
rights shall immediately vest in full, in the event of any Corporate
Transaction, except to the extent: (i) those repurchase rights are to be
assigned to the successor corporation (or parent thereof) in connection with
such Corporate Transaction or (ii) such accelerated vesting is precluded by
other limitations imposed by the Plan Administrator at the time the repurchase
right is issued.

           C.    Immediately following the consummation of the Corporate
Transaction, all outstanding options shall terminate and cease to be
outstanding, except to the extent assumed by the successor corporation (or
parent thereof).

           D.    Each option which is assumed in connection with a Corporate
Transaction shall be appropriately adjusted, immediately after such Corporate
Transaction, to apply to the number and class of securities which would have
been issuable to the Optionee in consummation of such Corporate Transaction
had the option been exercised immediately prior to such Corporate Transaction.
Appropriate adjustments to reflect such Corporate Transaction shall also be
made to (i) the exercise price payable per share under each outstanding
option, provided the aggregate exercise price payable for such securities
shall remain the same, (ii) the maximum number and/or class of securities
available for issuance over the remaining term of the Plan and (iii) the
maximum number and/or class of securities for which any one person may be
granted stock options, separately exercisable stock appreciation rights and
direct stock issuances under the Plan per calendar year.

           E.    The Plan Administrator shall have full power and authority to
grant one or more options under the Discretionary Option Grant Program which
will automatically accelerate in the event the Optionee's Service subsequently
terminates by reason of an Involuntary Termination within a designated period
(not to exceed eighteen (18) months) following the effective date of any
Corporate Transaction in which those options are assumed or replaced and do
not otherwise accelerate.  Any options so accelerated shall remain exercisable
for fully-vested shares until the earlier of (i) the expiration of the option
term or (ii) the expiration of the one (1)-year period measured from the
effective date of the Involuntary Termination.  In addition, the Plan
Administrator may provide that one or more of the Corporation's outstanding
repurchase rights with respect to shares held by the Optionee at the time of
such Involuntary Termination shall immediately terminate, and the shares
subject to those terminated repurchase rights shall accordingly vest in full.

           F.    The Plan Administrator shall have full power and authority to
grant one or more options under the Discretionary Option Grant Program which
will automatically accelerate in the event the Optionee's Service subsequently
terminates by reason of an Involuntary Termination within a designated period
(not to exceed eighteen (18) months) following the effective date of any
Change in Control.  Each option so accelerated shall remain exercisable for
fully-vested shares until the earlier of (i) the expiration of the option term
or (ii) the expiration of the one (1)-year period measured from the effective
date of the Involuntary Termination.  In addition, the Plan Administrator may

                                  -10-

<PAGE>


provide that one or more of the Corporation's outstanding repurchase rights
with respect to shares held by the Optionee at the time of such Involuntary
Termination shall immediately terminate, and the shares subject to those
terminated repurchase rights shall accordingly vest in full.

           G.    The portion of any Incentive Option accelerated in 
connection with a Corporate Transaction or Change in Control shall remain 
exercisable as an Incentive Option only to the extent the applicable One 
Hundred Thousand Dollar limitation is not exceeded.  To the extent such 
dollar limitation is exceeded, the accelerated portion of such option shall 
be exercisable as a Non-Statutory Option under the Federal tax laws.

           H.    The outstanding options shall in no way affect the right of 
the Corporation to adjust, reclassify, reorganize or otherwise change its 
capital or business structure or to merge, consolidate, dissolve, liquidate or 
sell or transfer all or any part of its business or assets.

     IV.   CANCELLATION AND REGRANT OF OPTIONS

           The Plan Administrator shall have the authority to effect, at any
time and from time to time, with the consent of the affected option holders,
the cancellation of any or all outstanding options under the Discretionary
Option Grant Program (including outstanding options incorporated from the
Predecessor Plan) and to grant in substitution new options covering the same
or different number of shares of Common Stock but with an exercise price per
share based on the Fair Market Value per share of Common Stock on the new
grant date.

                                  -11-


<PAGE>

                                 ARTICLE THREE

                            STOCK ISSUANCE PROGRAM
                            ----------------------            

     I.    STOCK ISSUANCE TERMS

           Shares of Common Stock may be issued under the Stock Issuance
Program through direct and immediate issuances without any intervening option
grants.  Each such stock issuance shall be evidenced by a Stock Issuance
Agreement which complies with the terms specified below.

           A.    PURCHASE PRICE.

                 1.   The purchase price per share shall be fixed by the Plan
Administrator, but shall not be less than one hundred percent (100%) of the
Fair Market Value per share of Common Stock on the issuance date.

                 2.   Subject to the provisions of Section I of Article Five, 
shares of Common Stock may be issued under the Stock Issuance Program for any 
of the following items of consideration which the Plan Administrator may deem
appropriate in each individual instance:

                      (i)    cash or check made payable to the Corporation, or

                      (ii)   past services rendered to the Corporation (or 
     any Parent or Subsidiary).

           B.    VESTING PROVISIONS.

                 1.   Shares of Common Stock issued under the Stock Issuance
Program may, in the discretion of the Plan Administrator, be fully and
immediately vested upon issuance or may vest in one or more installments over
the Participant's period of Service or upon attainment of specified
performance objectives.  The elements of the vesting schedule applicable to
any unvested shares of Common Stock issued under the Stock Issuance Program,
namely:

                      (i)    the Service period to be completed by the 
     Participant or the performance objectives to be attained,

                      (ii)   the number of installments in which the shares 
     are to vest,

                      (iii)  the interval or intervals (if any) which are to 
     lapse between installments, and

                                  -12

<PAGE>

                      (iv)   the effect which death, Permanent Disability or
     other event designated by the Plan Administrator is to have upon the 
     vesting schedule,

shall be determined by the Plan Administrator and incorporated into the Stock
Issuance Agreement.

                 2.   Any new, substituted or additional securities or other
property (including money paid other than as a regular cash dividend) which
the Participant may have the right to receive with respect to the
Participant's unvested shares of Common Stock by reason of any stock dividend,
stock split, recapitalization, combination of shares, exchange of shares or
other change affecting the outstanding Common Stock as a class without the
Corporation's receipt of consideration shall be issued subject to (i) the same
vesting requirements applicable to the Participant's unvested shares of Common
Stock and (ii) such escrow arrangements as the Plan Administrator shall deem
appropriate.

                 3.   The Participant shall have full stockholder rights with 
respect to any shares of Common Stock issued to the Participant under the 
Stock Issuance Program, whether or not the Participant's interest in those 
shares is vested.  Accordingly, the Participant shall have the right to vote 
such shares and to receive any regular cash dividends paid on such shares.

                 4.   Should the Participant cease to remain in Service while 
holding one or more unvested shares of Common Stock issued under the Stock 
Issuance Program or should the performance objectives not be attained with 
respect to one or more such unvested shares of Common Stock, then those shares 
shall be immediately surrendered to the Corporation for cancellation, and the
Participant shall have no further stockholder rights with respect to those
shares.  To the extent the surrendered shares were previously issued to the
Participant for consideration paid in cash or cash equivalent (including the
Participant's purchase-money indebtedness), the Corporation shall repay to the
Participant the cash consideration paid for the surrendered shares and
shall cancel the unpaid principal balance of any outstanding purchase-money
note of the Participant attributable to the surrendered shares.

                 5.   The Plan Administrator may in its discretion waive the 
surrender and cancellation of one or more unvested shares of Common Stock 
which would otherwise occur upon the cessation of the Participant's Service 
or the non-attainment of the performance objectives applicable to those shares.
Such waiver shall result in the immediate vesting of the Participant's
interest in the shares as to which the waiver applies.  Such waiver may be
effected at any time, whether before or after the Participant's cessation of
Service or the attainment or non-attainment of the applicable performance
objectives.

                                  -13-

<PAGE>

     II.   CORPORATE TRANSACTION/CHANGE IN CONTROL

           A.    All of the Corporation's outstanding repurchase rights under
the Stock Issuance Program shall terminate automatically, and all the shares
of Common Stock subject to those terminated rights shall immediately vest in
full, in the event of any Corporate Transaction, except to the extent (i)
those repurchase rights are to be assigned to the successor corporation (or
parent thereof) in connection with such Corporate Transaction or (ii) such
accelerated vesting is precluded by other limitations imposed in the Stock
Issuance Agreement.

           B.    The Plan Administrator shall have the discretionary
authority, exercisable either at the time the unvested shares are issued or
any time while the Corporation's repurchase rights with respect to such shares
remain outstanding under the Stock Issuance Program, to provide that those
rights shall automatically terminate in whole or in part, and the shares of
Common Stock subject to those terminated rights shall immediately vest, in the
event the Participant's Service should subsequently terminate by reason of an
Involuntary Termination within a designated period (not to exceed eighteen
(18) months) following the effective date of any Corporate Transaction in
which those repurchase rights are assigned to the successor corporation (or
parent thereof).

           C.    The Plan Administrator shall have the discretionary
authority, exercisable either at the time the unvested shares are issued or
any time while the Corporation's repurchase rights with respect to such shares
remain outstanding under the Stock Issuance Program, to provide that those
rights shall automatically terminate in whole or in part, and the shares of
Common Stock subject to those terminated rights shall immediately vest, in the
event the Participant's Service should subsequently terminate by reason of an
Involuntary Termination within a designated period (not to exceed eighteen
(18) months) following the effective date of any Change in Control.

     III.  SHARE ESCROW/LEGENDS

           Unvested shares may, in the Plan Administrator's discretion, be 
held in escrow by the Corporation until the Participant's interest in such 
shares vests or may be issued directly to the Participant with restrictive 
legends on the certificates evidencing those unvested shares.

                                  -14-

<PAGE>

                                  ARTICLE FOUR

                        AUTOMATIC OPTION GRANT PROGRAM
                        ------------------------------


     I.    OPTION TERMS

           A.    GRANT DATES.  Option grants shall be made on the dates 
specified below:

                 1.   Each individual who is first elected or appointed as a
non-employee Board member on or at any time after the Plan Effective Date
shall automatically be granted, on the date of such initial election or
appointment, a Non-Statutory Option to purchase 50,000 shares of Common Stock.

                 2.   Each non-employee Board member, whether elected or
appointed to the Board before or after the Plan Effective Date, shall receive
a series of additional 50,000-share Non-Statutory Options over his or her
period of continued Board service.  The first such additional 50,000-share
option grant shall be made at the Annual Stockholders Meeting held in the
calendar year in which the final one-third (1/3) annual installment of the
shares subject to the last previous automatic option grant made to such
individual under either the Predecessor Plan or this Plan vests.  Such
non-employee Board member shall receive an additional 50,000-share
Non-Statutory Option under this Automatic Option Grant Program on the date of
every third Annual Stockholders Meeting thereafter during his or her period of
continued Board service, and there will be no limit on the number of such
additional 50,000-share automatic option grants any one individual may receive
over his or her period of Board service.  Each such 50,000-share option grant
shall be made to the non-employee Board member, whether or not he or she is
standing for re-election at the Annual Stockholders Meeting at which the grant
is to be made, so long as he or she is to continue to serve as a non-employee
Board member.

           B.    EXERCISE PRICE.
 
                 1.   The exercise price per share shall be equal to one
hundred percent (100%) of the Fair Market Value per share of Common Stock on
the option grant date.

                 2.   The exercise price shall be payable in one or more of
the alternative forms authorized under the Discretionary Option Grant Program.
Except to the extent the sale and remittance procedure specified thereunder is
utilized, payment of the exercise price for the purchased shares must be made
on the Exercise Date.

           C.    OPTION TERM.  Each option shall have a term of ten (10) years
measured from the option grant date.

                                  -15-

<PAGE>

           D.    EXERCISE AND VESTING OF OPTIONS.  Each option shall be
immediately exercisable for any or all of the option shares.  However, any
shares purchased under the option shall be subject to repurchase by the
Corporation, at the exercise price paid per share, upon the Optionee's
cessation of Board service prior to vesting in those shares.  The shares
subject to each option grant shall vest, and the Corporation's repurchase
right with respect to those shares shall lapse, in a series of three (3)
successive equal annual installments upon the optionee's completion of each
year of Board service over the three (3)-year period measured from the option
grant date.

           E.    TERMINATION OF BOARD SERVICE.  The following provisions shall
govern the exercise of any options held by the Optionee at the time the
Optionee ceases to serve as a Board member:

                      (i)    The Optionee (or, in the event of Optionee's 
     death, the personal representative of the Optionee's estate or the 
     person or persons to whom the option is transferred pursuant to the 
     Optionee's will or in accordance with the laws of descent and 
     distribution) shall have a twelve (12)-month period following the date
     of such cessation of Board service in which to exercise each such option.

                      (ii)   During the twelve (12)-month exercise period, 
     the option may not be exercised in the aggregate for more than the 
     number of vested shares of Common Stock for which the option is 
     exercisable at the time of the Optionee's cessation of Board service.

                      (iii)  Should the Optionee cease to serve as a Board 
     member by reason of death or Permanent Disability, then all shares at 
     the time subject to the option shall immediately vest so that such 
     option may, during the twelve (12)-month exercise period following such
     cessation of Board service, be exercised for all or any portion of those
     shares as fully-vested shares of Common Stock.

                      (iv)   In no event shall the option remain exercisable 
     after the expiration of the option term.  Upon the expiration of the 
     twelve (12)-month exercise period or (if earlier) upon the expiration of
     the option term, the option shall terminate and cease to be outstanding 
     for any vested shares for which the option has not been exercised.  
     However, the option shall, immediately upon the Optionee's cessation of 
     Board service for any reason other than death or Permanent Disability,
     terminate and cease to be outstanding to the extent the option is not 
     otherwise at that time exercisable for vested shares.

                                  -16-

<PAGE>

     II.   CORPORATE TRANSACTION/CHANGE IN CONTROL

           A.    In the event of any Corporate Transaction, the shares of
Common Stock at the time subject to each outstanding option but not otherwise
vested shall automatically vest in full so that each such option shall,
immediately prior to the effective date of the Corporate Transaction, become
fully exercisable for all of the shares of Common Stock at the time subject to
such option and may be exercised for all or any portion of those shares as
fully-vested shares of Common Stock.  Immediately following the consummation
of the Corporate Transaction, each automatic option grant shall terminate and
cease to be outstanding, except to the extent assumed by the successor
corporation (or parent thereof).

           B.    In connection with any Change in Control, the shares of
Common Stock at the time subject to each outstanding option but not otherwise
vested shall automatically vest in full so that each such option shall,
immediately prior to the effective date of the Change in Control, become fully
exercisable for all of the shares of Common Stock at the time subject to such
option and may be exercised for all or any portion of those shares as
fully-vested shares of Common Stock.  Each such option shall remain
exercisable for such fully-vested option shares until the expiration or sooner
termination of the option term.

           C.     All outstanding repurchase rights under the Automatic Option
Grant Program shall also terminate automatically, and the unvested shares of
Common Stock subject to those terminated rights shall immediately vest in
full, in the event of any Corporate Transaction or Change in Control.

           D.    Each option which is assumed in connection with a Corporate
Transaction shall be appropriately adjusted, immediately after such Corporate
Transaction, to apply to the number and class of securities which would have
been issuable to the Optionee in consummation of such Corporate Transaction
had the option been exercised immediately prior to such Corporate Transaction.
Appropriate adjustments shall also be made to the exercise price payable per
share under each outstanding option, provided the aggregate exercise price
payable for such securities shall remain the same.

           E.    The grant of options under the Automatic Option Grant Program
shall in no way affect the right of the Corporation to adjust, reclassify,
reorganize or otherwise change its capital or business structure or to merge,
consolidate, dissolve, liquidate or sell or transfer all or any part of its
business or assets.

     III.  REMAINING TERMS

           The remaining terms of each option granted under the Automatic
Option Grant Program shall be the same as the terms in effect for option
grants made under the Discretionary Option Grant Program.

                                   -17-

<PAGE>

                                 ARTICLE FIVE

                                 MISCELLANEOUS
                                 -------------


     I.    FINANCING

           The Plan Administrator may permit any Optionee or Participant to 
pay the option exercise price under the Discretionary Option Grant Program or 
the purchase price of shares issued under the Stock Issuance Program by 
delivering a full-recourse, interest bearing promissory note payable in one 
or more installments.  The terms of any such promissory note (including the 
interest rate and the terms of repayment) shall be established by the Plan
Administrator in its sole discretion.  In no event may the maximum credit
available to the Optionee or Participant exceed the sum of (i) the aggregate
option exercise price or purchase price payable for the purchased shares plus
(ii) any Federal, state and local income and employment tax liability incurred
by the Optionee or the Participant in connection with the option exercise or
share purchase.

     II.   TAX WITHHOLDING

           A.    The Corporation's obligation to deliver shares of Common
Stock upon the exercise of options or the issuance or vesting of such shares
under the Plan shall be subject to the satisfaction of all applicable Federal,
state and local income and employment tax withholding requirements.

           B.    The Plan Administrator may, in its discretion, provide any or
all holders of Non-Statutory Options or unvested shares of Common Stock under
the Plan (other than the options granted or the shares issued under the
Automatic Option Grant Program) with the right to use shares of Common Stock
in satisfaction of all or part of the Taxes incurred by such holders in
connection with the exercise of their options or the vesting of their shares.
Such right may be provided to any such holder in either or both of the
following formats:

                 Stock Withholding:  The election to have the Corporation
withhold, from the shares of Common Stock otherwise issuable upon the exercise
of such Non-Statutory Option or the vesting of such shares, a portion of those
shares with an aggregate Fair Market Value equal to the percentage of the
Taxes (not to exceed one hundred percent (100%)) designated by the holder.

                 Stock Delivery:  The election to deliver to the Corporation, 
at the time the Non-Statutory Option is exercised or the shares vest, one or 
more shares of Common Stock previously acquired by such holder (other than in
connection with the option exercise or share vesting triggering the Taxes)
with an aggregate Fair Market Value equal to the percentage of the Taxes (not
to exceed one hundred percent (100%)) designated by the holder.

                                  -18-

<PAGE>

     III.  EFFECTIVE DATE AND TERM OF THE PLAN

           A.    The Plan was adopted by the Board in March 1997 and became
effective upon approval by the Corporation's stockholders at the 1997 Annual
Meeting held on the Plan Effective Date.

           B.    The Plan shall serve as the successor to the Predecessor
Plan, and no further option grants or direct stock issuances shall be made
under the Predecessor Plan after the Plan Effective Date.  All options
outstanding under the Predecessor Plan on the Plan Effective Date shall be
incorporated into the Plan at that time and shall be treated as outstanding
options under the Plan.  However, each outstanding option so incorporated
shall continue to be governed solely by the terms of the documents evidencing
such option, and no provision of the Plan shall be deemed to affect or
otherwise modify the rights or obligations of the holders of such incorporated
options with respect to their acquisition of shares of Common Stock.

           C.    One or more provisions of the Plan, including (without
limitation) the option/vesting acceleration provisions of Article Two relating
to Corporate Transactions and Changes in Control, may, in the Plan
Administrator's discretion, be extended to one or more options incorporated
from the Predecessor Plan which do not otherwise contain such provisions.

           D.    The Plan shall terminate upon the earliest of (i) May 19,
2007, (ii) the date on which all shares available for issuance under the Plan
shall have been issued as fully-vested shares or (iii) the termination of all
outstanding options in connection with a Corporate Transaction.  Upon such
plan termination, all outstanding option grants and unvested stock issuances
shall thereafter continue to have force and effect in accordance with the
provisions of the documents evidencing such grants or issuances.

     IV.   AMENDMENT OF THE PLAN

           A.    The Board shall have complete and exclusive power and
authority to amend or modify the Plan in any or all respects.  However, no
such amendment or modification shall adversely affect the rights and
obligations with respect to stock options or unvested stock issuances at the
time outstanding under the Plan unless the Optionee or the Participant
consents to such amendment or modification. In addition, certain amendments
may require stockholder approval pursuant to applicable laws or regulations.

           B.    Options to purchase shares of Common Stock may be granted
under the Discretionary Option Grant Program and shares of Common Stock may be
issued under the Stock Issuance Program that are in each instance in excess of
the number of shares then available for issuance under the Plan, provided any
excess shares actually issued under those programs shall be held in escrow
until there is obtained stockholder approval of an amendment sufficiently
increasing the number of shares of Common Stock available for issuance under
the Plan.   If such stockholder approval is not obtained within twelve (12)

                                  -19-

<PAGE>

months after the date the first such excess issuances are made, then (i) any
unexercised options granted on the basis of such excess shares shall terminate
and cease to be outstanding and (ii) the Corporation shall promptly refund to
the Optionees and the Participants the exercise or purchase price paid for any
excess shares issued under the Plan and held in escrow, together with interest
(at the applicable Short Term Federal Rate) for the period the shares were
held in escrow, and such shares shall thereupon be automatically cancelled and
cease to be outstanding.

     V.    USE OF PROCEEDS

           Any cash proceeds received by the Corporation from the sale of
shares of Common Stock under the Plan shall be used for general corporate
purposes.

     VI.   REGULATORY APPROVALS

           A.    The implementation of the Plan, the granting of any stock
option under the Plan and the issuance of any shares of Common Stock (i) upon
the exercise of any granted option or (ii) under the Stock Issuance Program
shall be subject to the Corporation's procurement of all approvals and permits
required by regulatory authorities having jurisdiction over the Plan, the
stock options granted under it and the shares of Common Stock issued pursuant
to it.

           B.    No shares of Common Stock or other assets shall be issued or
delivered under the Plan unless and until there shall have been compliance
with all applicable requirements of Federal and state securities laws,
including the filing and effectiveness of the Form S-8 registration statement
for the shares of Common Stock issuable under the Plan, and all applicable
listing requirements of any stock exchange (or the Nasdaq National Market, if
applicable) on which Common Stock is then listed for trading.

     VII.  NO EMPLOYMENT/SERVICE RIGHTS

           Nothing in the Plan shall confer upon the Optionee or the
Participant any right to continue in Service for any period of specific
duration or interfere with or otherwise restrict in any way the rights of the
Corporation (or any Parent or Subsidiary employing or retaining such person)
or of the Optionee or the Participant, which rights are hereby expressly
reserved by each, to terminate such person's Service at any time for any
reason, with or without cause.

                                  -20-

<PAGE>

                                  APPENDIX
                                  --------


           The following definitions shall be in effect under the Plan:

     A.    AUTOMATIC OPTION GRANT PROGRAM shall mean the automatic option grant
 program in effect under the Plan.

     B.    BOARD shall mean the Corporation's Board of Directors.

     C.    CHANGE IN CONTROL shall mean a change in ownership or control of 
the Corporation effected through either of the following transactions:

                 (i)  the acquisition, directly or indirectly by any person or 
     related group of persons (other than the Corporation or a person that 
     directly or indirectly controls, is controlled by, or is under common 
     control with, the Corporation), of beneficial ownership (within the 
     meaning of Rule 13d-3 of the 1934 Act) of securities possessing more 
     than fifty percent (50%) of the total combined voting power of the 
     Corporation's outstanding securities pursuant to a tender or exchange 
     offer made directly to the Corporation's stockholders which the Board
     does not recommend such stockholders to accept, or

                 (ii)  a change in the composition of the Board over a period
     of twenty-four (24) consecutive months or less such that a majority of 
     the Board members ceases, by reason of one or more contested elections 
     for Board membership, to be comprised of individuals who either (A) have
     been Board members continuously since the beginning of such period or 
     (B) have been elected or nominated for election as Board members during 
     such period by at least a majority of the Board members described in 
     clause (A) who were still in office at the time the Board approved such
     election or nomination.

     D.    CODE shall mean the Internal Revenue Code of 1986, as amended.

     E.    COMMON STOCK shall mean the Corporation's common stock.

     F.    CORPORATE TRANSACTION shall mean either of the following
stockholder-approved transactions to which the Corporation is a party:

                 (i)   a merger or consolidation in which securities 
     possessing more than fifty percent (50%) of the total combined voting 
     power of the Corporation's outstanding securities are transferred to a 
     person or persons different from the persons holding those securities 
     immediately prior to such transaction, or

                                   A-1

<PAGE>

                 (ii)  the sale, transfer or other disposition of all or 
     substantially all of the Corporation's assets in complete liquidation or
     dissolution of the Corporation.

     G.    CORPORATION shall mean Advanced Tissue Sciences Inc., a Delaware 
corporation, and its successors.

     H.    DISCRETIONARY OPTION GRANT PROGRAM shall mean the discretionary 
option grant program in effect under the Plan.

     I.    ELIGIBLE DIRECTOR shall mean a non-employee Board member eligible
to participate in the Automatic Option Grant Program in accordance with the
eligibility provisions of Article One.

     J.    EMPLOYEE shall mean an individual who is in the employ of the
Corporation (or any Parent or Subsidiary), subject to the control and
direction of the employer entity as to both the work to be performed and the
manner and method of performance.

     K.    EXERCISE DATE shall mean the date on which the Corporation shall
have received written notice of the option exercise.

     L.    FAIR MARKET VALUE per share of Common Stock on any relevant date
shall be determined in accordance with the following provisions:

                 (i)   If the Common Stock is at the time traded on the 
     Nasdaq National Market, then the Fair Market Value shall be deemed equal 
     to the closing selling price per share of Common Stock on the date in 
     question, as such price is reported on the Nasdaq National Market or any
     successor system.  If there is no closing selling price for the Common
     Stock on the date in question, then the Fair Market Value shall be the 
     closing selling price on the last preceding date for which such 
     quotation exists.

                 (ii)  If the Common Stock is at the time listed on any Stock
     Exchange, then the Fair Market Value shall be deemed equal to the 
     closing selling price per share of Common Stock on the date in question 
     on the Stock Exchange determined by the Plan Administrator to be the 
     primary market for the Common Stock, as such price is officially quoted
     in the composite tape of transactions on such exchange.  If there is no 
     closing selling price for the Common Stock on the date in question, then
     the Fair Market Value shall be the closing selling price on the last 
     preceding date for which such quotation exists.

                                   A-2

<PAGE>

     M.    INCENTIVE OPTION shall mean an option which satisfies the 
requirements of Code Section 422.

     N.    INVOLUNTARY TERMINATION shall mean the termination of the Service of
any individual which occurs by reason of:

                 (i)   such individual's involuntary dismissal or discharge 
     by the Corporation for reasons other than Misconduct, or

                 (ii)  such individual's voluntary resignation following 
     (A) a change in his or her position with the Corporation which 
     materially reduces his or her level of responsibility, (B) a reduction
     in his or her level of compensation (including base salary, fringe 
     benefits and participation in any corporate-performance based bonus or 
     incentive programs) by more than fifteen percent (15%) or (C) a 
     relocation of such individual's place of employment by more than fifty
     (50) miles, provided and only if such change, reduction or relocation  
     is effected by the Corporation without the individual's consent.

     O.    MISCONDUCT shall mean the commission of any act of fraud,
embezzlement or dishonesty by the Optionee or Participant, any unauthorized
use or disclosure by such person of confidential information or trade secrets
of the Corporation (or any Parent or Subsidiary), or any other intentional
misconduct by such person adversely affecting the business or affairs of the
Corporation (or any Parent or Subsidiary) in a material manner.  The foregoing
definition shall not be deemed to be inclusive of all the acts or omissions  
which the Corporation (or any Parent or Subsidiary) may consider as grounds 
for the dismissal or discharge of any Optionee, Participant or other person  
in the Service of the Corporation (or any Parent or Subsidiary).

     P.    1934 ACT shall mean the Securities Exchange Act of 1934, as 
amended.

     Q.    NON-STATUTORY OPTION shall mean an option not intended to satisfy  
the requirements of Code Section 422.

     R.    OPTIONEE shall mean any person to whom an option is granted under 
the Discretionary Option Grant or Automatic Option Grant Program.

     S.    PARENT shall mean any corporation (other than the Corporation) in
an unbroken chain of corporations ending with the Corporation, provided each
corporation in the unbroken chain (other than the Corporation) owns, at the
time of the determination, stock possessing fifty percent (50%) or more of the
total combined voting power of all classes of stock in one of the other
corporations in such chain.

     T.    PARTICIPANT shall mean any person who is issued shares of Common
Stock under the Stock Issuance Program.

                                  A-3

<PAGE>

     U.    PERMANENT DISABILITY OR PERMANENTLY DISABLED shall mean the
inability of the Optionee or the Participant to engage in any substantial
gainful activity by reason of any medically determinable physical or mental
impairment expected to result in death or to be of continuous duration of
twelve (12) months or more.  However, solely for purposes of the Automatic
Option Grant Program, Permanent Disability or Permanently Disabled shall mean
the inability of the non-employee Board member to perform his or her usual
duties as a Board member by reason of any medically determinable physical or
mental impairment expected to result in death or to be of continuous duration
of twelve (12) months or more.

     V.    PLAN shall mean the Corporation's 1997 Stock Incentive Plan, as
set forth in this document.

     W.    PLAN ADMINISTRATOR shall mean the particular entity, whether the
Primary Committee, the Board or the Secondary Committee, which is authorized
to administer the Discretionary Option Grant and Stock Issuance Programs with
respect to one or more classes of eligible persons, to the extent such entity
is carrying out its administrative functions under those programs with respect
to the persons under its jurisdiction.

     X.    PLAN EFFECTIVE DATE shall mean May 20, 1997, the date of the 1997
Annual Stockholders Meeting at which the Plan was approved by the
Corporation's stockholders.

     Y.    PREDECESSOR PLAN shall mean the Corporation's 1992 Stock
Option/Stock Issuance Plan, in effect immediately prior to the Plan Effective
Date hereunder.

     Z.    PRIMARY COMMITTEE shall mean the committee of two (2) or more
non-employee Board members appointed by the Board to administer the
Discretionary Option Grant and Stock Issuance Programs with respect to Section
16 Insiders.

     AA.   SECONDARY COMMITTEE shall mean a committee of one (1) or more
Board members appointed by the Board to administer the Discretionary Option
Grant and Stock Issuance Programs with respect to eligible persons other than
Section 16 Insiders.

     AB.   SECTION 16 INSIDER shall mean an officer or director of the
Corporation subject to the short-swing profit liabilities of Section 16 of the
1934 Act.

     AC.   SERVICE shall mean the performance of services for the
Corporation (or any Parent or Subsidiary) by a person in the capacity of an
Employee, a non-employee member of the board of directors or a consultant or
independent advisor, except to the extent otherwise specifically provided in
the documents evidencing the option grant or stock issuance.

     AD.   STOCK EXCHANGE shall mean either the American Stock Exchange or
the New York Stock Exchange.

                                   A-4

<PAGE>

     AE.   STOCK ISSUANCE AGREEMENT shall mean the agreement entered into by
the Corporation and the Participant at the time of issuance of shares of
Common Stock under the Stock Issuance Program.

     AF.   STOCK ISSUANCE PROGRAM shall mean the stock issuance program in
effect under the Plan.

     AG.   SUBSIDIARY shall mean any corporation (other than the
Corporation) in an unbroken chain of corporations beginning with the
Corporation, provided each corporation (other than the last corporation) in
the unbroken chain owns, at the time of the determination, stock possessing
fifty percent (50%) or more of the total combined voting power of all classes
of stock in one of the other corporations in such chain.

     AH.   TAXES shall mean the Federal, state and local income and
employment tax liabilities incurred by the holder of Non-Statutory Options or
unvested shares of Common Stock in connection with the exercise of those
options or the vesting of those shares.

     AI.   10% STOCKHOLDER shall mean the owner of stock (as determined
under Code Section 424(d)) possessing more than ten percent (10%) of the total
combined voting power of all classes of stock of the Corporation (or any
Parent or Subsidiary).

                                   A-5





                                                                  EXHIBIT 99.2


                       ADVANCED TISSUE SCIENCES, INC.
                       FORM OF STOCK OPTION AGREEMENT
                       ------------------------------

RECITALS
- --------

     A.    The Board has adopted the Plan for the purpose of retaining the
services of selected Employees, non-employee members of the Board or of the
board of directors of any Parent or Subsidiary and consultants and other
independent advisors who provide services to the Corporation (or any Parent or
Subsidiary).

     B.    Optionee is to render valuable services to the Corporation (or a
Parent or Subsidiary), and this Agreement is executed pursuant to, and is
intended to carry out the purposes of, the Plan in connection with the
Corporation's grant of an option to Optionee.

     C.    All capitalized terms in this Agreement shall have the meaning 
assigned to them in the attached Appendix.

           NOW, THEREFORE, it is hereby agreed as follows:

           1.    GRANT OF OPTION.  The Corporation hereby grants to Optionee,
as of the Grant Date, an option to purchase up to the number of Option Shares
specified in the Grant Notice.  The Option Shares shall be purchasable from
time to time during the option term specified in Paragraph 2 at the Exercise
Price.

           2.    OPTION TERM.  This option shall have a maximum term of ten
(10) years measured from the Grant Date and shall accordingly expire at the
close of business on the Expiration Date, unless sooner terminated in
accordance with Paragraph 5 or 6.

           3.    LIMITED TRANSFERABILITY.  This option shall be neither
transferable nor assignable by Optionee other than by will or by the laws of
descent and distribution following Optionee's death and may be exercised,
during Optionee's lifetime, only by Optionee.  However, if this option is
designated a Non-Statutory Option in the Grant Notice, then this option may,
in connection with the Optionee's estate plan, be assigned in whole or in part
during Optionee's lifetime to one or more members of the Optionee's immediate
family or to a trust established for the exclusive benefit of one or more such
family members.  The assigned portion shall be exercisable only by the person
or persons who acquire a proprietary interest in the option pursuant to such
assignment.  The terms applicable to the assigned portion shall be the same as
those in effect for this option immediately prior to such assignment and shall
be set forth in such documents issued to the assignee as the Plan
Administrator may deem appropriate.

                                   -1-

<PAGE>

           4.    DATES OF EXERCISE.  This option shall become exercisable for
the Option Shares in one or more installments as specified in the Grant
Notice.  As the option becomes exercisable for such installments, those
installments shall accumulate and the option shall remain exercisable for the
accumulated installments until the Expiration Date or sooner termination of
the option term under Paragraph 5 or 6.

           5.    CESSATION OF SERVICE.  The option term specified in Paragraph
2 shall terminate (and this option shall cease to be outstanding) prior to the
Expiration Date should any of the following provisions become applicable:

                      (1)  Should Optionee cease to remain in Service for any
     reason (other than death, Permanent Disability or Misconduct) while
     this option is outstanding, then Optionee shall have a period of three 
     (3) months (commencing with the date of such cessation of Service) 
     during which to exercise this option, but in no event shall this option 
     be exercisable at any time after the Expiration Date.

                      (2)  If Optionee dies while this option is outstanding, 
     then the personal representative of Optionee's estate or the person  
     or persons to whom the option is transferred pursuant to Optionee's
     will or in accordance with the laws of descent and distribution shall 
     have the right to exercise this option.  Such right shall lapse, and 
     this option shall cease to be outstanding, upon the earlier of (A) the 
     expiration of the twelve (12)- month period measured from the date of 
     Optionee's death or (B) the Expiration Date.

                      (3)  Should Optionee cease Service by reason of 
     Permanent Disability while this option is outstanding, then Optionee 
     shall have a period of twelve (12) months (commencing with the date of 
     such cessation of Service) during which to exercise this option.  In 
     no event shall this option be exercisable at any time after the 
     Expiration Date.

                      (4)  During the limited period of post-Service 
     exercisability, this option may not be exercised in the aggregate for 
     more than the number of vested Option Shares for which the option is 
     exercisable at the time of Optionee's cessation of Service.  Upon the 
     expiration of such limited exercise period or (if earlier) upon the 
     Expiration Date, this option shall terminate and cease to be outstanding
     for any vested Option Shares for which the option has not been 
     exercised.  However, this option shall, immediately upon Optionee's 
     cessation of Service for any reason, terminate and cease to be 
     outstanding with respect to any Option Shares in which Optionee is
     not otherwise at that time vested or for which this option is not 
     otherwise at that time exercisable.

                                   -2-

<PAGE>


                      (5)  Should Optionee's Service be terminated for 
     Misconduct, then this option shall terminate immediately and cease to 
     remain outstanding.

           6.    SPECIAL ACCELERATION OF OPTION.

                 a.   This option, to the extent outstanding at the time of a
Corporate Transaction but not otherwise fully exercisable, shall automatically
accelerate so that this option shall, immediately prior to the effective date
of the Corporate Transaction, become exercisable for all of the Option Shares
at the time subject to this option and may be exercised for any or all of
those Option Shares as fully-vested shares of Common Stock.  No such
acceleration of this option, however, shall occur if and to the extent: (i)
this option is, in connection with the Corporate Transaction, to be assumed by
the successor corporation (or parent thereof) or (ii) this option is to be
replaced with a cash incentive program of the successor corporation which
preserves the spread existing at the time of the Corporate Transaction on any
Option Shares for which this option is not otherwise at that time exercisable
(the excess of the Fair Market Value of those Option Shares over the aggregate
Exercise Price payable for such shares) and provides for subsequent pay-out in
accordance with the same option exercise/vesting schedule set forth in the
Grant Notice.

                 b.   Immediately following the Corporate Transaction, this
option shall terminate and cease to be outstanding, except to the extent
assumed by the successor corporation (or parent thereof) in connection with
the Corporate Transaction.

                 c.   If this option is assumed in connection with a Corporate
Transaction, then this option shall be appropriately adjusted, immediately
after such Corporate Transaction, to apply to the number and class of
securities which would have been issuable to Optionee in consummation of such
Corporate Transaction had the option been exercised immediately prior to such
Corporate Transaction, and appropriate adjustments shall also be made to the
Exercise Price, provided the aggregate Exercise Price shall remain the same.

                 d.   This Agreement shall not in any way affect the right of
the Corporation to adjust, reclassify, reorganize or otherwise change its
capital or business structure or to merge, consolidate, dissolve, liquidate or
sell or transfer all or any part of its business or assets.

           7.    ADJUSTMENT IN OPTION SHARES.  Should any change be made to
the Common Stock by reason of any stock split, stock dividend,
recapitalization, combination of shares, exchange of shares or other change
affecting the outstanding Common Stock as a class without the Corporation's
receipt of consideration, appropriate adjustments shall be made to (i) the
total number and/or class of securities subject to this option and (ii) the
Exercise Price in order to reflect such change and thereby preclude a dilution
or enlargement of benefits hereunder.

                                   -3-

<PAGE>


           8.    STOCKHOLDER RIGHTS.  The holder of this option shall not have
any stockholder rights with respect to the Option Shares until such person
shall have exercised the option, paid the Exercise Price and become a holder
of record of the purchased shares.

           9.    MANNER OF EXERCISING OPTION.

                 a.   In order to exercise this option with respect to all or
any part of the Option Shares for which this option is at the time
exercisable, Optionee (or any other person or persons exercising the option)
must take the following actions:

                      (1)  Execute and deliver to the Corporation a Notice of 
     Exercise for the Option Shares for which the option is exercised.

                      (2)  Pay the aggregate Exercise Price for the purchased
     shares in one or more of the following forms:

                         (a)  cash or check made payable to the Corporation;

                         (b)  a promissory note payable to the Corporation,
           but only to the extent authorized by the Plan Administrator in 
           accordance with Paragraph 13;

                         (c)  shares of Common Stock held by Optionee (or
           any other person or persons exercising the option) for the 
           requisite period necessary to avoid a charge to the Corporation's 
           earnings for financial reporting purposes and valued at Fair 
           Market Value on the Exercise Date; or

                         (d)  to the extent the option is exercised for
           vested Option Shares, through a special sale and remittance 
           procedure pursuant to which Optionee (or any other person or 
           persons exercising the option) shall concurrently provide 
           irrevocable instructions (I) to a Corporation-designated
           brokerage firm to effect the immediate sale of the purchased 
           shares and remit to the Corporation, out of the sale proceeds 
           available on the settlement date, sufficient funds to cover the  
           aggregate Exercise Price payable for the purchased shares plus 
           all applicable Federal, state and local income and employment  
           taxes required to be withheld by the Corporation by reason of such
           exercise and (II) to the Corporation to deliver the certificates 
           for the purchased shares directly to such brokerage firm in order 
           to complete the sale transaction.

                                   -4-

<PAGE>

                 Except to the extent the sale and remittance procedure is
           utilized in connection with the option exercise, payment of the 
           Exercise Price must accompany the Notice of Exercise delivered to
           the Corporation in connection with the option exercise.

                      (3)  Furnish to the Corporation appropriate
     documentation that the person or persons exercising the option (if 
     other than Optionee) have the right to exercise this option.

                      (4)  Make appropriate arrangements with the
     Corporation (or Parent or Subsidiary employing or retaining Optionee) 
     for the satisfaction of all Federal, state and local income and 
     employment tax withholding requirements applicable to the option  
     exercise.

                 b.   As soon as practical after the Exercise Date, the
Corporation shall issue to or on behalf of Optionee (or any other person or
persons exercising this option) a certificate for the purchased Option Shares,
with the appropriate legends affixed thereto.

                 c.   In no event may this option be exercised for any 
fractional shares.

           10.   COMPLIANCE WITH LAWS AND REGULATIONS.

                 a.   The exercise of this option and the issuance of the
Option Shares upon such exercise shall be subject to compliance by the
Corporation and Optionee with all applicable requirements of law relating
thereto and with all applicable regulations of any stock exchange (or the
Nasdaq National Market, if applicable) on which the Common Stock may be listed
for trading at the time of such exercise and issuance.

                 b.   The inability of the Corporation to obtain approval from
any regulatory body having authority deemed by the Corporation to be necessary
to the lawful issuance and sale of any Common Stock pursuant to this option
shall relieve the Corporation of any liability with respect to the
non-issuance or sale of the Common Stock as to which such approval shall not
have been obtained.  The Corporation, however, shall use its best efforts to
obtain all such approvals.

           11.   SUCCESSORS AND ASSIGNS.  Except to the extent otherwise
provided in Paragraphs 3 and 6, the provisions of this Agreement shall inure
to the benefit of, and be binding upon, the Corporation and its successors and
assigns and Optionee, Optionee's assigns and the legal representatives, heirs
and legatees of Optionee's estate.

                                   -5-

<PAGE>
      
           12.   NOTICES.  Any notice required to be given or delivered to
the Corporation under the terms of this Agreement shall be in writing and
addressed to the Corporation at its principal corporate offices.  Any notice
required to be given or delivered to Optionee shall be in writing and
addressed to Optionee at the address indicated below Optionee's signature line
on the Grant Notice.  All notices shall be deemed effective upon personal
delivery or upon deposit in the U.S. mail, postage prepaid and properly
addressed to the party to be notified.

           13.   FINANCING.  The Plan Administrator may, in its absolute
discretion and without any obligation to do so, permit Optionee to pay the
Exercise Price for the purchased Option Shares by delivering a full-recourse
promissory note payable to the Corporation.  The terms of any such promissory
note (including the interest rate, the requirements for collateral and the
terms of repayment) shall be established by the Plan Administrator in its sole
discretion.

           14.   CONSTRUCTION.  This Agreement and the option evidenced
hereby are made and granted pursuant to the Plan and are in all respects
limited by and subject to the terms of the Plan.  All decisions of the Plan
Administrator with respect to any question or issue arising under the Plan or
this Agreement shall be conclusive and binding on all persons having an
interest in this option.

           15.   GOVERNING LAW.  The interpretation, performance and
enforcement of this Agreement shall be governed by the laws of the State of
California without resort to that State's conflict-of-laws rules.

           16.   EXCESS SHARES.  If the Option Shares covered by this
Agreement exceed, as of the Grant Date, the number of shares of Common Stock
which may without stockholder approval be issued under the Plan, then this
option shall be void with respect to those excess shares, unless stockholder
approval of an amendment sufficiently increasing the number of shares of
Common Stock issuable under the Plan is obtained in accordance with the
provisions of the Plan.

           17.   ADDITIONAL TERMS APPLICABLE TO AN INCENTIVE OPTION.  In the
event this option is designated an Incentive Option in the Grant Notice, the
following terms and conditions shall also apply to the grant:

                      (i)    This option shall cease to qualify for
     favorable tax treatment as an Incentive Option if (and to the extent) 
     this option is exercised for one or more Option Shares: (A) more than 
     three (3) months after the date Optionee ceases to be an Employee for 
     any reason other than death or Permanent Disability or (B) more than 
     twelve (12) months after the date Optionee ceases to be an Employee by 
     reason of Permanent Disability.

                      (ii)   No installment under this option shall

                                   -6-

<PAGE>

     qualify for favorable tax treatment as an Incentive Option if (and to 
     the extent) the aggregate Fair Market Value (determined at the Grant 
     Date) of the Common Stock for which such installment first becomes 
     exercisable hereunder would, when added to the aggregate value 
     (determined as of the respective date or dates  of  grant) of the 
     Common Stock or other securities for which this option or any other 
     Incentive Options granted to Optionee prior to the Grant Date (whether
     under the Plan or any other option plan of the Corporation or any  
     Parent or Subsidiary) first become exercisable during the same calendar
     year, exceed One Hundred Thousand Dollars ($100,000) in the aggregate.  
     Should such One Hundred Thousand Dollar ($100,000) limitation be 
     exceeded in any calendar year, this option shall nevertheless become 
     exercisable for the excess shares in such calendar year as a Non-
     Statutory Option.

                      (iii)  Should the exercisability of this option be
     accelerated upon a Corporate Transaction, then this option shall qualify
     for favorable tax treatment as an Incentive Option only to the extent 
     the aggregate Fair Market Value (determined at the Grant Date) of the 
     Common Stock for which this option first becomes exercisable in the 
     calendar year in which the Corporate Transaction occurs does not, when 
     added to the aggregate value (determined as of the respective date or 
     dates of grant) of the Common Stock or other securities for which this
     option or one or more other Incentive Options granted to Optionee prior 
     to the Grant Date (whether under the Plan or any other option plan of 
     the Corporation or any Parent or Subsidiary) first become exercisable 
     during the same calendar year, exceed One Hundred Thousand Dollars  
     ($100,000) in the aggregate.  Should the applicable One Hundred
     Thousand Dollar ($100,000) limitation be exceeded in the calendar year 
     of such Corporate Transaction, the option may nevertheless be exercised 
     for the excess shares in such calendar year as a Non-Statutory Option.

                      (iv)   Should Optionee hold, in addition to this
     option, one or more other options to purchase Common Stock which become
     exercisable for the first time in the same calendar year as this option,
     then the foregoing limitations on the exercisability of such options as 
     Incentive Options shall be applied on the basis of the order in which 
     such options are granted.

                                   -7-

<PAGE>


                                 EXHIBIT I

                            NOTICE OF EXERCISE



           I hereby notify Advanced Tissue Sciences, Inc. (the "Corporation")
that I elect to purchase _______ shares of the Corporation's Common Stock 
(the "Purchased Shares") at the option exercise price of $_______ per share 
(the "Exercise Price") pursuant to that certain option (the "Option") granted
to me under the Corporation's 1997 Stock Incentive Plan on _________,  199_.

           Concurrently with the delivery of this Exercise Notice to the
Corporation, I shall hereby pay to the Corporation the Exercise Price for the
Purchased Shares in accordance with the provisions of my agreement with the
Corporation (or other documents) evidencing the Option and shall deliver
whatever additional documents may be required by such agreement as a condition
for exercise.  Alternatively, I may utilize the special broker-dealer sale and
remittance procedure specified in my agreement to effect payment of the
Exercise Price.


_________________, 199_
Date


                                           ______________________________
                                           Optionee

                                           Address:______________________
                                           ______________________________

Print name in exact manner
it is to appear on the
stock certificate:                         ______________________________

Address to which certificate
is to be sent, if different
from address above:                        ______________________________

                                           ______________________________

Social Security Number:                    ______________________________

Employee Number:                           ______________________________

                                   -8-

<PAGE>


                                  APPENDIX
                                  --------



           The following definitions shall be in effect under the Agreement:

      A.   AGREEMENT shall mean this Stock Option Agreement.

      B.   BOARD shall mean the Corporation's Board of Directors.

      C.   CODE shall mean the Internal Revenue Code of 1986, as amended.

      D.   COMMON STOCK shall mean the Corporation's common stock.

      E.   CORPORATE TRANSACTION shall mean either of the following
stockholder-approved transactions to which the Corporation is a party:

                 (i)  a merger or consolidation in which securities
     possessing more than fifty percent (50%) of the total combined voting 
     power of the Corporation's outstanding securities are transferred to a 
     person or persons different from the persons holding those securities 
     immediately prior to such transaction, or

                 (ii) the sale, transfer or other disposition of all or
     substantially all of the Corporation's assets in complete liquidation 
     or dissolution of the Corporation.

     F.    CORPORATION shall mean Advanced Tissue Sciences, Inc., a Delaware
corporation.

     G.    EMPLOYEE shall mean an individual who is in the employ of the
Corporation (or any Parent or Subsidiary), subject to the control and
direction of the employer entity as to both the work to be performed and the
manner and method of performance.

     H.    EXERCISE DATE shall mean the date on which the option shall have
been exercised in accordance with Paragraph 9 of the Agreement.

     I.    EXERCISE PRICE shall mean the exercise price per share as 
specified in the Grant Notice.

     J.    EXPIRATION DATE shall mean the date on which the option expires 
as specified in the Grant Notice.

     K.    FAIR MARKET VALUE per share of Common Stock on any relevant date 
shall be determined in accordance with the following provisions:

                                   A-1

<PAGE>


                 (i)  If the Common Stock is at the time traded on the Nasdaq
     National Market, then the Fair Market Value shall be the closing selling
     price per share of Common Stock on the date in question, as the price is
     reported by the National Association of Securities Dealers on the Nasdaq
     National Market or any successor system.  If there is no closing selling
     price for the Common Stock on the date in question, then the Fair Market
     Value shall be the closing selling price on the last preceding date for 
     which such quotation exists.

                 (ii) If the Common Stock is at the time listed on any Stock
     Exchange, then the Fair Market Value shall be the closing selling price 
     per share of Common Stock on the date in question on the Stock Exchange 
     determined by the Plan Administrator to be the primary market for the 
     Common Stock, as such price is officially quoted in the composite tape 
     of transactions on such exchange.  If there is no closing selling price 
     for the Common Stock on the date in question, then the Fair Market Value
     shall be the closing selling price on the last preceding date for which
     such quotation exists.

     L.    GRANT DATE shall mean the date of grant of the option as specified
in the Grant Notice.

     M.    GRANT NOTICE shall mean the Notice of Grant of Stock Option
accompanying the Agreement, pursuant to which Optionee has been informed of
the basic terms of the option evidenced hereby.

     N.    INCENTIVE OPTION shall mean an option which satisfies the
requirements of Code Section 422.

     O.    MISCONDUCT shall mean the commission of any act of fraud,
embezzlement or dishonesty by Optionee, any unauthorized use or disclosure by
Optionee of confidential information or trade secrets of the Corporation (or
any Parent or Subsidiary), or any other intentional misconduct by Optionee
adversely affecting the business or affairs of the Corporation (or any Parent
or Subsidiary) in a material manner.  The foregoing definition shall not be
deemed to be inclusive of all the acts or omissions which the Corporation (or
any Parent or Subsidiary) may consider as grounds for the dismissal or
discharge of Optionee or any other individual in the Service of the
Corporation (or any Parent or Subsidiary).

     P.    NON-STATUTORY OPTION shall mean an option not intended to satisfy
the requirements of Code Section 422.

     Q.    NOTICE OF EXERCISE shall mean the notice of exercise in the form 
attached hereto as Exhibit I.

                                   A-2

<PAGE>

     R.    OPTION SHARES shall mean the number of shares of Common Stock 
subject to the option as specified in the Grant Notice.

     S.    OPTIONEE shall mean the person to whom the option is granted as 
specified in the Grant Notice.

     T.    PARENT shall mean any corporation (other than the Corporation) in
an unbroken chain of corporations ending with the Corporation, provided each
corporation in the unbroken chain (other than the Corporation) owns, at the
time of the determination, stock possessing fifty percent (50%) or more of the
total combined voting power of all classes of stock in one of the other
corporations in such chain.

     U.    PERMANENT DISABILITY shall mean the inability of Optionee to
engage in any substantial gainful activity by reason of any medically
determinable physical or mental impairment which is expected to result in
death or has lasted or can be expected to last for a continuous period of
twelve (12) months or more.

     V.    PLAN shall mean the Corporation's 1997 Stock Incentive Plan.

     W.    PLAN ADMINISTRATOR shall mean either the Board or a committee of
the Board acting in its capacity as administrator of the Plan.

     X.    SERVICE shall mean the Optionee's performance of services for the
Corporation (or any Parent or Subsidiary) in the capacity of an Employee, a
non-employee member of the board of directors or a consultant or independent
advisor.

     Y.    STOCK EXCHANGE shall mean the American Stock Exchange or the New
York Stock Exchange.

     Z.    SUBSIDIARY shall mean any corporation (other than the Corporation)
in an unbroken chain of corporations beginning with the Corporation, provided
each corporation (other than the last corporation) in the unbroken chain owns,
at the time of the determination, stock possessing fifty percent (50%) or more
of the total combined voting power of all classes of stock in one of the other
corporations in such chain.

                                   A-3




                                                                 Exhibit 99.3

                                  
                             FORM OF ADDENDUM
                                    TO
                          STOCK OPTION AGREEMENT


           The following provisions are hereby incorporated into, and are
hereby made a part of, that certain Stock Option Agreement (the "Option
Agreement") by and between Advanced Tissue Sciences, Inc. (the "Corporation")
and ______________ ("Optionee") evidencing the stock option (the "Option") 
granted to Optionee under the terms of the Corporation's 1997 Stock Incentive
Plan, and such provisions shall be effective immediately.  All capitalized 
terms in this Addendum, to the extent not otherwise defined herein, shall have 
the meanings assigned to them in the Option Agreement.


                      INVOLUNTARY TERMINATION FOLLOWING
                   CORPORATE TRANSACTION/CHANGE IN CONTROL

           1.    To the extent the Option is, in connection with a Corporate
Transaction, to be assumed by the successor entity (or its parent company),
the Option shall not accelerate upon the occurrence of that Corporate
Transaction, and the Option shall accordingly continue, over Optionee's period
of Service after the Corporate Transaction, to become exercisable for the
Option Shares in one or more installments in accordance with the provisions of
the Option Agreement.  However, immediately upon an Involuntary Termination of
Optionee's Service within eighteen (18) months following such Corporate
Transaction, the Option (or any replacement grant), to the extent outstanding
at the time but not otherwise fully exercisable, shall automatically
accelerate so that the Option shall become immediately exercisable for all the
Option Shares at the time subject to the Option and may be exercised for any
or all of those Option Shares as fully vested shares.

           2.    The Option shall not accelerate upon the occurrence of a
Change in Control, and the Option shall, over Optionee's period of Service
following such Change in Control, continue to become exercisable for the
Option Shares in one or more installments in accordance with the provisions of
the Option Agreement.  However, immediately upon an Involuntary Termination of
Optionee's Service within eighteen (18) months following the Change in
Control, the Option, to the extent outstanding at the time but not otherwise
fully exercisable, shall automatically accelerate so that the Option shall
become immediately exercisable for all the Option Shares at the time subject
to the Option and may be exercised for any or all of those Option Shares as
fully vested shares.

           3.    The Option shall remain so exercisable until the earlier of
(i) the Expiration Date or (ii) the expiration of the one (1)-year period
measured from the date of such Involuntary Termination.

<PAGE>


           4.    For purposes of this Addendum the following definitions shall 
be in effect:

                      (i)    An INVOLUNTARY TERMINATION shall mean the 
termination of Optionee's Service by reason of:

                             -   Optionee's involuntary dismissal or 
           discharge by the Corporation for reasons other than Misconduct, or

                             -   Optionee's voluntary resignation following 
           (A) a change in Optionee's position with the Corporation (or 
           Parent or Subsidiary employing Optionee) which materially reduces
           Optionee's level of responsibility, (B) a reduction in Optionee's 
           level of compensation (including base salary, fringe benefits and 
           target bonus under any corporate-performance based bonus or 
           incentive programs) by more than fifteen percent (15%) or (C) a
           relocation of Optionee's place of employment by more than fifty 
           (50) miles, provided and only if such change, reduction or 
           relocation is effected by the Corporation without Optionee's  
           consent, and
                    
                      (ii)   A CHANGE IN CONTROL shall be deemed to occur in
the event of a change in ownership or control of the Corporation effected
through either of the following transactions:

                             -   the acquisition, directly or indirectly, by 
           any person or related group of persons (other than the Corporation
           or a person that directly or indirectly controls, or is controlled
           by, or is under common control with, the Corporation) of 
           beneficial ownership (within the meaning of Rule 13d-3 of the 
           Securities Exchange Act of 1934, as amended) of securities 
           possessing more than fifty percent (50%) of the total combined 
           voting power of the Corporation's outstanding securities pursuant
           to a tender or exchange offer made directly to the Corporation's 
           stockholders which the Board does not recommend such stockholders
           to accept, or

                                   -2-

<PAGE>

                             -   a change in the composition of the Board 
           over a period of twenty-four (24) consecutive months or less such 
           that a majority of the Board members ceases, by reason of one or 
           more contested elections for Board membership, to be comprised of 
           individuals who either (i) have been Board members continuously  
           since the beginning of such period or (ii) have been elected or 
           nominated for election as Board members during such period by
           at least a majority of the Board members described in clause (i) 
           who were still in office at the time such election or nomination 
           was approved by the Board.

           5.    The provisions of Paragraph 3 of this Addendum shall govern
the period for which the Option is to remain exercisable following the
Involuntary Termination of Optionee's Service within eighteen (18) months
after the Corporate Transaction or Change in Control and shall supersede any
provisions to the contrary in Paragraph 5 of the Option Agreement.

           IN WITNESS WHEREOF, Advanced Tissue Sciences, Inc. has caused this
Addendum to be executed by its duly-authorized officer as of the Effective
Date specified below.


                                          ADVANCED TISSUE SCIENCES, INC.


                                          By:____________________________

                                          Title:_________________________


EFFECTIVE DATE: ____________, 199_


                                   -3-




                                                                  Exhibit 99.4


                       ADVANCED TISSUE SCIENCES, INC.
                      FORM OF STOCK ISSUANCE AGREEMENT
                      --------------------------------


           AGREEMENT made as of this ________ day of________ 199_, by and
between Advanced Tissue Sciences, Inc., a Delaware corporation and 
_________________________, a Participant in the Corporation's 1997 Stock  
Incentive Plan.

           All capitalized terms in this Agreement shall have the meaning
assigned to them in this Agreement or in the attached Appendix.

     A.    PURCHASE OF SHARES
 
           1.    PURCHASE.  Participant hereby purchases ________ shares of 
Common Stock (the "Purchased Shares") pursuant to the provisions of the Stock
Issuance Program at the purchase price of $______ per share (the "Purchase
Price").

           2.    PAYMENT.  Concurrently with the delivery of this Agreement to
the Corporation, Participant shall pay the Purchase Price for the Purchased
Shares in cash or check payable to the Corporation and shall deliver a
duly-executed blank Assignment Separate from Certificate (in the form attached
hereto as Exhibit I) with respect to the Purchased Shares.

           3.    STOCKHOLDER RIGHTS.  Until such time as the Corporation
exercises the Repurchase Right, Participant (or any successor in interest)
shall have all the rights of a stockholder (including voting, dividend and
liquidation rights) with respect to the Purchased Shares, subject, however, to
the transfer restrictions of this Agreement.

           4.    ESCROW.  The Corporation shall have the right to hold the
Purchased Shares in escrow until those shares have vested in accordance with
the Vesting Schedule.

           5.    COMPLIANCE WITH LAW.  Under no circumstances shall shares of
Common Stock or other assets be issued or delivered to Participant pursuant to
the provisions of this Agreement unless, in the opinion of counsel for the
Corporation or its successors, there shall have been compliance with all
applicable requirements of Federal and state securities laws, all applicable
listing requirements of any stock exchange (or the Nasdaq National Market, if
applicable) on which the Common Stock is at the time listed for trading and
all other requirements of law or of any regulatory bodies having
jurisdiction over such issuance and delivery.

<PAGE>

     B.    TRANSFER RESTRICTIONS

           1.    RESTRICTION ON TRANSFER.  Except for any Permitted Transfer,
Participant shall not transfer, assign, encumber or otherwise dispose of any
of the Purchased Shares which are subject to the Repurchase Right.

           2.    RESTRICTIVE LEGEND.  The stock certificate for the Purchased
Shares shall be endorsed with the following restrictive legend:

                 "The shares represented by this certificate are unvested and
     subject to certain repurchase rights granted to the Corporation and
     accordingly may not be sold, assigned, transferred, encumbered, or in 
     any manner disposed of except in conformity with the terms of a written 
     agreement dated ___________, 199_ between the Corporation and the 
     registered holder of the shares (or the predecessor in interest to the  
     shares).  A copy of such agreement is maintained at the Corporation's  
     principal corporate offices."

           3.    TRANSFEREE OBLIGATIONS.  Each person (other than the
Corporation) to whom the Purchased Shares are transferred by means of a
Permitted Transfer must, as a condition precedent to the validity of such
transfer, acknowledge in writing to the Corporation that such person is bound
by the provisions of this Agreement and that the transferred shares are
subject to the Repurchase Right to the same extent such shares would be so
subject if retained by Participant.

     C.    REPURCHASE RIGHT

           1.    GRANT.  The Corporation is hereby granted the right (the
"Repurchase Right"), exercisable at any time during the ninety (90)-day period
following the date Participant ceases for any reason to remain in Service, to
repurchase at the Purchase Price all or any portion of the Purchased Shares in
which Participant is not, at the time of his or her cessation of Service,
vested in accordance with the Vesting Schedule set forth in Paragraph C.3 or
the special acceleration provisions of Paragraph C.5 (such shares to be
hereinafter referred to as the "Unvested Shares").

           2.    EXERCISE OF THE REPURCHASE RIGHT.  The Repurchase Right shall
be exercisable by written notice delivered to each Owner of the Unvested
Shares prior to the expiration of the ninety (90)-day exercise period.  The
notice shall indicate the number of Unvested Shares to be repurchased and the
date on which the repurchase is to be effected, such date to be not more than
thirty (30) days after the date of such notice.  The certificates representing
the Unvested Shares to be repurchased shall be delivered to the Corporation on
or before the close of business on the date specified for the repurchase.
Concurrently with the receipt of such stock certificates, the Corporation
shall pay to Owner, in cash or cash equivalent (including the cancellation of
any purchase-money indebtedness), an amount equal to the Purchase Price

                                   -2-

<PAGE>


previously paid for the Unvested Shares to be repurchased from Owner.

           3.    TERMINATION OF THE REPURCHASE RIGHT.  The Repurchase Right
shall terminate with respect to any Unvested Shares for which it is not timely
exercised under Paragraph C.2.  In addition, the Repurchase Right shall
terminate and cease to be exercisable with respect to any and all Purchased
Shares in which Participant vests in accordance with the following Vesting
Schedule:

                    (i)      Upon Participant's completion of one (1) year of
     Service measured from ______________, 199__, Participant shall acquire a
     vested interest in, and the Repurchase Right shall lapse with respect to,
     twenty-five percent (25%) of the Purchased Shares.

                    (ii)     Participant shall acquire a vested interest in,
     and the Repurchase Right shall lapse with respect to, the remaining 
     Purchased Shares in a series of thirty six (36) successive equal monthly 
     installments upon Participant's completion of each additional month of 
     Service over the thirty-six (36)-month period measured from the initial 
     vesting date under subparagraph (i) above.

           4.    RECAPITALIZATION.  Any new, substituted or additional
securities or other property (including cash paid other than as a regular cash
dividend) which is by reason of any Recapitalization distributed with respect
to the Purchased Shares shall be immediately subject to the Repurchase Right
and any escrow requirements hereunder, but only to the extent the Purchased
Shares are at the time covered by such right or escrow requirements.
Appropriate adjustments to reflect such distribution shall be made to the
number and/or class of Purchased Shares subject to this Agreement and to the
price per share to be paid upon the exercise of the Repurchase Right in order
to reflect the effect of any such Recapitalization upon the Corporation's
capital structure; provided, however, that the aggregate purchase price shall
remain the same.

           5.    CORPORATE TRANSACTION.

                 (a)  Immediately prior to the consummation of any Corporate
Transaction, the Repurchase Right shall automatically lapse in its entirety
and the Purchased Shares shall vest in full, except to the extent the
Repurchase Right is to be assigned to the successor corporation (or parent
thereof) in connection with the Corporate Transaction.

                 (b)  To the extent the Repurchase Right remains in effect
following a Corporate Transaction, such right shall apply to any new
securities or other property (including any cash payments) received in
exchange for the Purchased Shares in consummation of the Corporate
Transaction, but only to the extent the Purchased Shares are at the time
covered by such right.  Appropriate adjustments shall be made to the price per
share payable upon exercise of the Repurchase Right to reflect the effect of
the Corporate Transaction upon the Corporation's capital structure; provided,

                                   -3-

<PAGE>


however, that the aggregate purchase price shall remain the same.  The new
securities or other property (including any cash payments) issued or
distributed with respect to the Purchased Shares in consummation of the
Corporate Transaction shall be immediately deposited in escrow with the
Corporation (or the successor entity) and shall not be released from escrow
until Optionee vests in such securities or other property in accordance with
the same Vesting Schedule in effect for the Purchased Shares.

                 (c)  The Repurchase Right may also be subject to termination
in whole or in part on an accelerated basis, and the Purchased Shares subject
to immediate vesting, in accordance with the terms of any special Addendum
attached to this Agreement.

     D.    SPECIAL TAX ELECTION

           1.    SECTION 83(B) ELECTION.  Under Code Section 83, the excess of
the fair market value of the Purchased Shares on the date any forfeiture
restrictions applicable to such shares lapse over the Purchase Price paid for
such shares will be reportable as ordinary income on the lapse date.  For this
purpose, the term "forfeiture restrictions" includes the right of the
Corporation to repurchase the Purchased Shares pursuant to the Repurchase
Right.  Participant may elect under Code Section 83(b) to be taxed at the time
the Purchased Shares are acquired, rather than when and as such Purchased
Shares cease to be subject to such forfeiture restrictions.  Such election
must be filed with the Internal Revenue Service within thirty (30) days after
the date of this Agreement.  Even if the fair market value of the Purchased
Shares on the date of this Agreement equals the Purchase Price paid (and thus
no tax is payable), the election must be made to avoid adverse tax
consequences in the future.  THE FORM FOR MAKING THIS ELECTION IS ATTACHED AS
EXHIBIT II HERETO.  PARTICIPANT UNDERSTANDS THAT FAILURE TO MAKE THIS FILING
WITHIN THE APPLICABLE THIRTY (30)-DAY PERIOD WILL RESULT IN THE RECOGNITION OF
ORDINARY INCOME AS THE FORFEITURE RESTRICTIONS LAPSE.

           2.    FILING RESPONSIBILITY.  PARTICIPANT ACKNOWLEDGES THAT IT IS
PARTICIPANT'S SOLE RESPONSIBILITY, AND NOT THE CORPORATION'S, TO FILE A TIMELY
ELECTION UNDER CODE SECTION 83(B), EVEN IF PARTICIPANT REQUESTS THE
CORPORATION OR ITS REPRESENTATIVES TO MAKE THIS FILING ON HIS OR HER BEHALF.

     E.    GENERAL PROVISIONS

           1.     ASSIGNMENT.  The Corporation may assign the Repurchase Right
to any person or entity selected by the Board, including (without limitation)
one or more stockholders of the Corporation.

                                   -4-

<PAGE>

           2.    NO EMPLOYMENT OR SERVICE CONTRACT.  Nothing in this Agreement
or in the Plan shall confer upon Participant any right to continue in Service
for any period of specific duration or interfere with or otherwise restrict in
any way the rights of the Corporation (or any Parent or Subsidiary employing
or retaining Participant) or of Participant, which rights are hereby expressly
reserved by each, to terminate Participant's Service at any time for any
reason, with or without cause.

           3.    NOTICES.  Any notice required to be given under this
Agreement shall be in writing and shall be deemed effective upon personal
delivery or upon deposit in the U.S. mail, registered or certified, postage
prepaid and properly addressed to the party entitled to such notice at the
address indicated below such party's signature line on this Agreement or at
such other address as such party may designate by ten (10) days advance
written notice under this paragraph to all other parties to this Agreement.

           4.    NO WAIVER.  The failure of the Corporation in any instance to
exercise the Repurchase Right shall not constitute a waiver of any other
repurchase rights that may subsequently arise under the provisions of this
Agreement or any other agreement between the Corporation and Participant.  No
waiver of any breach or condition of this Agreement shall be deemed to be a
waiver of any other or subsequent breach or condition, whether of like or
different nature.

           5.    CANCELLATION OF SHARES.  If the Corporation shall make
available, at the time and place and in the amount and form provided in this
Agreement, the consideration for the Purchased Shares to be repurchased in
accordance with the provisions of this Agreement, then from and after such
time, the person from whom such shares are to be repurchased shall no longer
have any rights as a holder of such shares (other than the right to receive
payment of such consideration in accordance with this Agreement).  Such shares
shall be deemed purchased in accordance with the applicable provisions hereof,
and the Corporation shall be deemed the owner and holder of such shares,
whether or not the certificates therefor have been delivered as required by
this Agreement.

           6.    PARTICIPANT UNDERTAKING.  Participant hereby agrees to take
whatever additional action and execute whatever additional documents the
Corporation may deem necessary or advisable in order to carry out or effect
one or more of the obligations or restrictions imposed on either Participant
or the Purchased Shares pursuant to the provisions of this Agreement.

           7.    AGREEMENT IS ENTIRE CONTRACT.  This Agreement constitutes the
entire contract between the parties hereto with regard to the subject matter
hereof.  This Agreement is made pursuant to the provisions of the Plan and
shall in all respects be construed in conformity with the terms of the Plan.

           8.    GOVERNING LAW.  This Agreement shall be governed by, and
construed in accordance with, the laws of the State of California without
resort to that State's conflict-of-laws rules.

                                   -5-

<PAGE>

           9.    COUNTERPARTS.  This Agreement may be executed in
counterparts, each of which shall be deemed to be an original, but all of
which together shall constitute one and the same instrument.

           10.   SUCCESSORS AND ASSIGNS.  The provisions of this Agreement
shall inure to the benefit of, and be binding upon, the Corporation and its
successors and assigns and upon Participant, Participant's assigns and the
legal representatives, heirs and legatees of Participant's estate, whether or
not any such person shall have become a party to this Agreement and have
agreed in writing to join herein and be bound by the terms hereof.

           IN WITNESS WHEREOF, the parties have executed this Agreement on the 
day and year first indicated above.


                                          ADVANCED TISSUE SCIENCES, INC.




                                          By:_____________________________

                                          Title:__________________________

                                          Address:________________________

                                          ________________________________



                                          ________________________________
                                                    PARTICIPANT

                                          Address:________________________

                                          ________________________________


                                   -6-

<PAGE>

                                  EXHIBIT I
                     ASSIGNMENT SEPARATE FROM CERTIFICATE


           FOR VALUE RECEIVED ____________________  hereby sell(s), assign(s)
and transfer(s) unto Advanced Tissue Sciences, Inc. (the "Corporation"), 
(__________) shares of the Common Stock of the Corporation standing in his 
or her name on the books of the Corporation represented by Certificate 
No. ________  herewith and do(es) hereby irrevocably constitute and appoint 
______________________ Attorney to transfer the said stock on the books of 
the Corporation with full power of substitution in the premises.


Dated:_______________________




                              Signature____________________________________









INSTRUCTION:  Please do not fill in any blanks other than the signature line.
Please sign exactly as you would like your name to appear on the issued stock
certificate.  The purpose of this assignment is to enable the Corporation to
exercise the Repurchase Right without requiring additional signatures on the
part of Participant.

<PAGE>


                                  EXHIBIT II

                          SECTION 83(B) TAX ELECTION

This statement is being made under Section 83(b) of the Internal Revenue Code, 
pursuant to Treas. Reg. Section 1.83-2.

(1)   The taxpayer who performed the services is:

      Name:
      Address:
      Taxpayer Ident. No.:

(2)   The property with respect to which the election is being made is ______
      shares of the common stock of Advanced Tissue Sciences, Inc.

(3)   The property was issued on ____________, 199_.

(4)   The taxable year in which the election is being made is the calendar 
      year 199_.

(5)   The property is subject to a repurchase right pursuant to which the
      issuer has the right to acquire the property at the original purchase 
      price if for any reason taxpayer's employment with the issuer is 
      terminated.  The issuer's repurchase right lapses in a series of 
      installments over a four (4)-year period ending on ___________, 199_.

(6)   The fair market value at the time of transfer (determined without
      regard to any restriction other than a restriction which by its terms 
      will never lapse) is $________ per share.

(7)   The amount paid for such property is $_________ per share.

(8)   A copy of this statement was furnished to Advanced Tissue Sciences,
      Inc. for whom taxpayer rendered the services underlying the transfer of
      property.

(9)   This statement is executed on ________________________, 199__.


__________________________________     ______________________________________
Spouse (if any)                        Taxpayer

This election must be filed with the Internal Revenue Service Center with
which taxpayer files his or her Federal income tax returns and must be made
within thirty (30) days after the execution date of the Stock Issuance
Agreement.  This filing should be made by registered or certified mail, return
receipt requested.  Participant must retain two (2) copies of the completed
form for filing with his or her Federal and state tax returns for the current
tax year and an additional copy for his or her records.

<PAGE>

                                   APPENDIX
                                   --------


           The following definitions shall be in effect under the Agreement:


     A.    AGREEMENT shall mean this Stock Issuance Agreement.

     B.    BOARD shall mean the Corporation's Board of Directors.

     C.    CODE shall mean the Internal Revenue Code of 1986, as amended.

     D.    COMMON STOCK shall mean the Corporation's common stock.

     E.    CORPORATE TRANSACTION shall mean either of the following 
stockholder-approved transactions:

                 (i)    a merger or consolidation in which securities
     possessing more than fifty percent (50%) of the total combined voting 
     power of the Corporation's outstanding securities are transferred to a 
     person or persons different from the persons holding those securities 
     immediately prior to such transaction, or

                 (ii)   the sale, transfer or other disposition of all or
     substantially all of the Corporation's assets in complete liquidation or
     dissolution of the Corporation.

     F.    CORPORATION shall mean Advanced Tissue Sciences, Inc., a Delaware
corporation.

     G.    OWNER shall mean Participant and all subsequent holders of the
Purchased Shares who derive their chain of ownership through a Permitted
Transfer from Participant.

     H.    PARENT shall mean any corporation (other than the Corporation) in
an unbroken chain of corporations ending with the Corporation, provided each
corporation in the unbroken chain (other than the Corporation) owns, at the
time of the determination, stock possessing fifty percent (50%) or more of the
total combined voting power of all classes of stock in one of the other
corporations in such chain.

     I.    PARTICIPANT shall mean the person to whom shares are issued under
the Stock Issuance Program.

     J.    PERMITTED TRANSFER shall mean (i) a gratuitous transfer of the
Purchased Shares, provided and only if Participant obtains the Corporation's
prior written consent to such transfer, (ii) a transfer of title to the
Purchased Shares effected pursuant to Participant's will or the laws of
intestate succession following Participant's death or (iii) a transfer to the

                                   A-1

<PAGE>


Corporation in pledge as security for any purchase-money indebtedness incurred
by Participant in connection with the acquisition of the Purchased Shares.

     K.    PLAN shall mean the Corporation's 1997 Stock Incentive Plan.

     L.    PLAN ADMINISTRATOR shall mean either the Board or a committee of
the Board acting in its capacity as administrator of the Plan.

     M.    PURCHASE PRICE shall have the meaning assigned to such term in 
Paragraph A.1.

     N.    PURCHASED SHARES shall have the meaning assigned to such term in 
Paragraph A.1.

     O.    RECAPITALIZATION shall mean any stock split, stock dividend,
recapitalization, combination of shares, exchange of shares or other change
affecting the outstanding Common Stock as a class without the Corporation's
receipt of consideration.

     P.    REORGANIZATION shall mean any of the following transactions:

                  (i)   a merger or consolidation in which the Corporation
     is not the surviving entity,

                  (ii)  a sale, transfer or other disposition of all or
     substantially all of the Corporation's assets,
  
                  (iii) a reverse merger in which the Corporation is the
     surviving entity but in which the Corporation's outstanding voting 
     securities are transferred in whole or in part to a person or persons 
     different from the persons holding those securities immediately prior  
     to the merger, or

                  (iv)  any transaction effected primarily to change the state
     in which the Corporation is incorporated or to create a holding company
     structure.

     Q.    REPURCHASE RIGHT shall mean the right granted to the Corporation
in accordance with Article C.

     R.    SERVICE shall mean the Participant's performance of services for
the Corporation (or any Parent or Subsidiary) in the capacity of an employee,
subject to the control and direction of the employer entity as to both the
work to be performed and the manner and method of performance, a non-employee
member of the board of directors or a consultant or independent advisor.

     S.    STOCK ISSUANCE PROGRAM shall mean the Stock Issuance Program under
the Plan.

                                   A-2

<PAGE>

     T.    SUBSIDIARY shall mean any corporation (other than the Corporation)
in an unbroken chain of corporations beginning with the Corporation, provided
each corporation (other than the last corporation) in the unbroken chain owns,
at the time of the determination, stock possessing fifty percent (50%) or more
of the total combined voting power of all classes of stock in one of the other
corporations in such chain.

     U.    VESTING SCHEDULE shall mean the vesting schedule specified in
Paragraph C.3 pursuant to which the Purchased Shares are to vest in
installments over the Participant's period of Service.

     V.    UNVESTED SHARES shall have the meaning assigned to such term in
Paragraph C.1.


                                   A-3




                                                                  EXHIBIT 99.5


                             FORM OF ADDENDUM
                                    TO
                         STOCK ISSUANCE AGREEMENT


           The following provisions are hereby incorporated into, and are
hereby made a part of, that certain Stock Issuance Agreement dated ________  
(the "Issuance Agreement") by and between Advanced  Tissue Sciences, Inc. (the
"Corporation") and ___________________ ("Participant") evidencing the stock 
issuance on such date to Participant under the terms of the Corporation's 
1997 Stock Incentive Plan, and such provisions shall be effective 
immediately.  All capitalized terms in this Addendum, to the extent not 
otherwise defined herein, shall have the meanings assigned to such terms in  
the Issuance Agreement.


                      INVOLUNTARY TERMINATION FOLLOWING
                   CORPORATE TRANSACTION/CHANGE IN CONTROL

           1.    To the extent the Repurchase Right is assigned to the
successor entity (or parent company) in connection with a Corporate
Transaction, no accelerated vesting of the Purchased Shares shall occur upon
such Corporate Transaction, and the Repurchase Right shall continue to remain
in full force and effect in accordance with the provisions of the Issuance
Agreement.  Accordingly, the Participant shall, over Participant's period of
Service following the Corporate Transaction, continue to vest in the Purchased
Shares in one or more installments in accordance with the provisions of the
Issuance Agreement.

           2.    No accelerated vesting of the Purchased Shares shall occur
upon a Change in Control, and the Repurchase Right shall continue to remain in
full force and effect in accordance with the provisions of the Issuance
Agreement.  Accordingly, the Participant shall, over Participant's period of
Service following the Change in Control, continue to vest in the Purchased
Shares in one or more installments in accordance with the provisions of the
Issuance Agreement.

           3.    Immediately upon an Involuntary Termination of Participant's
Service within eighteen (18) months following the Corporate Transaction or
Change in Control, the Repurchase Right shall terminate automatically, and all
the Purchased Shares shall vest in full.

           4.    For purposes of this Addendum, the following definitions 
shall be in effect:

                 An INVOLUNTARY TERMINATION shall mean the termination of 
Participant's Service by reason of:

                    (i)      Participant's involuntary dismissal or discharge
     by the Corporation for reasons other than Misconduct, or

<PAGE>

                    (ii)     Participant's voluntary resignation following (A)
     a change in Participant's position with the Corporation (or Parent or
     Subsidiary employing Participant) which materially reduces Participant's 
     level of responsibility, (B) a reduction in Participant's level of 
     compensation (including base salary, fringe benefits and target bonus  
     under any corporate-performance based bonus or incentive programs) by 
     more than fifteen percent (15%) or (C) a relocation of Participant's 
     place of employment by more than fifty (50) miles, provided and only  
     if such change, reduction or relocation is effected by the Corporation
     without Participant's consent.

           A  CHANGE IN CONTROL shall be deemed to occur in the event of a
change in ownership or control of the Corporation effected through either of
the following transactions:

                    (i)      the acquisition, directly or indirectly, by any
     person or related group of persons (other than the Corporation or a 
     person that directly or indirectly controls, is controlled by, or is 
     under common control with, the Corporation) of beneficial ownership 
     (within the meaning of Rule 13d-3 of the Securities Exchange Act of 
     1934, as amended) of securities possessing more than fifty percent (50%)
     of the total combined voting power of the Corporation's outstanding  
     securities pursuant to a tender or exchange offer made directly to the 
     Corporation's stockholders which the Board does not recommend such 
     stockholders to accept, or

                    (ii)     a change in the composition of the Board over a
     period of twenty-four (24) consecutive months or less such that a 
     majority of the Board members ceases, by reason of one or more contested
     elections for Board membership, to be comprised of individuals who 
     either (A) have been Board members continuously since the beginning of 
     such period or (B) have been elected or nominated for election as Board 
     members during such period by at least a majority of the Board members 
     described in clause (A) who were still in office at the time such 
     election or nomination was approved by the Board.

           MISCONDUCT shall mean the commission of any act of fraud,
embezzlement or dishonesty by the Participant, any unauthorized use or
disclosure by the Participant of confidential information or trade secrets of
the Corporation (or any Parent or Subsidiary), or any other intentional
misconduct by the Participant adversely affecting the business or affairs of
the Corporation (or any Parent or Subsidiary) in a material manner.  The
foregoing definition shall not be deemed to be inclusive of all the acts or
omissions which the Corporation (or any Parent or Subsidiary) may consider as
grounds for the dismissal or discharge of the Participant or other person in
the Service of the Corporation (or any Parent or Subsidiary).

                                   -2-

<PAGE>

           IN WITNESS WHEREOF, Advanced Tissue Sciences, Inc. has caused this
Addendum to be executed by its duly-authorized officer as of the Effective
Date specified below.



                                         ADVANCED TISSUE SCIENCES, INC.

                                        
                                         By:_____________________________

                                         Title:__________________________




EFFECTIVE DATE:________________, 199_



                                   -3-





                                                                  EXHIBIT 99.6

                        ADVANCED TISSUE SCIENCES, INC.
                   FORM OF AUTOMATIC STOCK OPTION AGREEMENT
                   ----------------------------------------


RECITALS
- --------

     A.    The Corporation has implemented an automatic option grant program
under the Plan pursuant to which eligible non-employee members of the Board
will automatically receive special option grants at periodic intervals over
their period of Board service in order to provide such individuals with a
meaningful incentive to continue to serve as members of the Board.

     B.    Optionee is an eligible non-employee Board member, and this
Agreement is executed pursuant to, and is intended to carry out the purposes
of, the Plan in connection with the automatic grant of an option to purchase
shares of Common Stock under the Plan.

     C.    All capitalized terms in this Agreement shall have the meaning 
assigned to them in the attached Appendix.

           NOW, THEREFORE, it is hereby agreed as follows:

           1.    GRANT OF OPTION.  The Corporation hereby grants to Optionee,
as of the Grant Date, a Non-Statutory Option to purchase up to the number of
Option Shares specified in the Grant Notice.  The Option Shares shall be
purchasable from time to time during the option term specified in Paragraph 2
at the Exercise  Price.

           2.    OPTION TERM.  This option shall have a term of ten (10) years
measured from the Grant Date and shall accordingly expire at the close of
business on the Expiration Date, unless sooner terminated in accordance with
Paragraph 5, 6 or 7.

           3.    LIMITED TRANSFERABILITY.  This option may, in connection with
the Optionee's estate plan, be assigned in whole or in part during Optionee's
lifetime to one or more members of the Optionee's immediate family or to a
trust established for the exclusive benefit of one or more such family
members.  The assigned portion shall be exercisable only by the person or
persons who acquire a proprietary interest in the option pursuant to such
assignment.  The terms applicable to the assigned portion shall be the same as
those in effect for this option immediately prior to such assignment and shall
be set forth in such documents issued to the assignee as the Corporation may
deem appropriate. Should the Optionee die while holding this option, then this
option shall be transferred in accordance with Optionee's will or the laws of
descent and distribution.

                                   -1-

<PAGE>

           4.    EXERCISABILITY/VESTING.

                 (a)    This option shall be immediately exercisable for any 
or all of the Option Shares, whether or not the Option Shares are vested in
accordance with the Vesting Schedule and shall remain so exercisable until the
Expiration Date or sooner termination of the option term under Paragraph 5, 6
or 7.

                 (b)    Optionee shall, in accordance with the Vesting 
Schedule set forth in the Grant Notice, vest in the Option Shares in a series 
of installments over his or her period of Board service.  Vesting in the 
Option Shares may be accelerated pursuant to the provisions of Paragraph 5, 
6 or 7.  In no event, however, shall any additional Option Shares vest 
following Optionee's cessation of service as a Board member.

           5.    CESSATION OF BOARD SERVICE.  Should Optionee's service as a
Board member cease while this option remains outstanding, then the option term
specified in Paragraph 2 shall terminate (and this option shall cease to be
outstanding) prior to the Expiration Date in accordance with the following
provisions:

                 (a)    Should Optionee cease to serve as a Board member for
any reason (other than death or Permanent Disability) while holding this
option, then the period for exercising this option shall be reduced to a
twelve (12)-month period (commencing with the date of such cessation of Board
service), but in no event shall this option be exercisable at any time after
the Expiration Date.  During such limited period of exercisability, this
option may not be exercised in the aggregate for more than the number of
Option Shares (if any) in which Optionee is vested on the date of his or her
cessation of Board service.  Upon the earlier  of (i) the expiration of such
twelve (12)-month period or (ii) the specified Expiration Date, the option
shall terminate and cease to be exercisable with respect to any vested Option
Shares for which the option has not been exercised.

                 (b)    Should Optionee die during the twelve (12)-month 
period following his or her cessation of Board service, then the personal
representative of Optionee's estate or the person or persons to whom the
option is transferred pursuant to Optionee's will or in accordance with the
laws of descent and distribution shall have the right to exercise this option
for any or all of the Option Shares in which Optionee is vested at the time of
Optionee's cessation of Board service (less any Option Shares purchased by
Optionee after such cessation of Board service but prior to death).  Such
right of exercise shall terminate, and this option shall accordingly cease to
be exercisable for such vested Option Shares, upon the earlier of (i) the
expiration of the twelve (12)-month period measured from the date of
Optionee's cessation of Board service or (ii) the specified Expiration Date.

                                   -2-

<PAGE>

                 (c)    Should Optionee cease service as a Board member by
reason of death or Permanent Disability, then all Option Shares at the time
subject to this option but not otherwise vested shall vest in full so that
Optionee (or the personal representative of Optionee's estate or the person or
persons to whom the option is transferred upon Optionee's death) shall have
the right to exercise this option for any or all of the Option Shares as
fully-vested shares of Common Stock at any time prior to the earlier of (i)
the expiration of the twelve (12)-month  period measured from the date of
Optionee's cessation of Board service or (ii) the specified Expiration Date.

                 (d)    Upon Optionee's cessation of Board service for any
reason other than death or Permanent Disability, this option shall immediately
terminate and cease to be outstanding with respect to any and all Option
Shares in which Optionee is not otherwise at that time vested in accordance
with the normal Vesting Schedule or the special vesting acceleration
provisions of Paragraph 6 or 7 below.

           6.    CORPORATE TRANSACTION.

                 (a)    In the event of a Corporate Transaction, all Option
Shares at the time subject to this option but not otherwise vested shall
automatically vest so that this option shall, immediately prior to the
specified effective date for the Corporate Transaction, become fully
exercisable for all of the Option Shares at the time subject to this option
and may be exercised for all or any portion of such shares as fully-vested
shares of Common Stock.  Immediately following the consummation of the
Corporate Transaction, this option shall terminate and cease to be
outstanding, except to the extent assumed by the successor corporation or its
parent company.

                 (b)    If this option is assumed in connection with a
Corporate Transaction, then this option shall be appropriately adjusted,
immediately after such Corporate Transaction, to apply to the number and class
of securities which would have been issuable to Optionee in consummation of
such Corporate Transaction had the option been exercised immediately prior to
such Corporate Transaction, and appropriate adjustments shall also be made to
the Exercise Price, provided the aggregate Exercise Price shall remain the
same.

           7.    CHANGE IN CONTROL.  All Option Shares subject to this option
at the time of a Change in Control but not otherwise vested shall
automatically vest so that this option shall, immediately prior to the
effective date of such Change in Control, become fully exercisable for all of
the Option Shares at the time subject to this option and may be exercised for
all or any portion of such shares as fully-vested shares of Common Stock.
This option shall remain exercisable for such fully-vested Option Shares until
the earliest to occur of (i) the Expiration Date, (ii) the sooner termination
of this option in accordance with Paragraph 5 or 6 or (iii) the surrender of
the option in connection with a Hostile Take-Over.

                                   -3-

<PAGE>


           8.    ADJUSTMENT IN OPTION SHARES.  Should any change be made to
the Common Stock by reason of any stock split, stock dividend,
recapitalization, combination of shares, exchange of shares or other change
affecting the outstanding Common Stock as a class without the Corporation's
receipt of consideration, appropriate adjustments shall be made to (i) the
total number and/or class of securities subject to this option and (ii) the
Exercise Price in order to reflect such change and thereby preclude a dilution
or enlargement of benefits hereunder.

           9.    STOCKHOLDER RIGHTS.  The holder of this option shall not have
any stockholder rights with respect to the Option Shares until such person
shall have exercised the option, paid the Exercise Price and become a holder
of record of the purchased shares.

           10.   MANNER OF EXERCISING OPTION.

                 (a)    In order to exercise this option with respect to all 
or any part of the Option Shares for which this option is at the time
exercisable, Optionee (or any other person or persons exercising the option)
must take the following actions:

                        (i)     To the extent the option is exercised for
     vested Option Shares, execute and deliver to the Corporation a Notice of
     Exercise for the Option Shares for which the option is exercised.  To the
     extent this option is exercised for unvested Option Shares, execute and
     deliver to the Corporation a Purchase Agreement for those unvested Option
     Shares.

                        (ii)    Pay the aggregate Exercise Price for the 
     purchased shares in one or more of the following forms:

                             (A)  cash or check made payable to the 
           Corporation,

                             (B)  shares of Common Stock held by Optionee (or
           any other person or persons exercising the option) for the 
           requisite period necessary to avoid a charge to the Corporation's
           earnings for financial reporting purposes and valued at Fair 
           Market Value on the Exercise Date, or

                             (C)  to the extent the option is exercised for
           vested Option Shares, through a special sale and remittance 
           procedure pursuant to which Optionee (or any other person or 
           persons exercising the option) shall concurrently provide 
           irrevocable instructions (I) to a Corporation-designated
           brokerage firm to effect the immediate sale of the purchased 
           shares and remit to the Corporation, out of the sale proceeds 
           available on the settlement date, sufficient funds to cover the
           aggregate Exercise Price payable for the purchased shares plus 

                                   -4-

<PAGE>

           all applicable Federal, state and local income and employment  
           taxes required to be withheld by the Corporation by reason of such
           exercise and (II) to the Corporation to deliver the certificates 
           for the purchased shares directly to such brokerage firm in order 
           to complete the sale.

                        (iii)   Furnish to the Corporation appropriate
     documentation that the person or persons exercising the option (if other 
     than Optionee) have the right to exercise this option.

                 (b)    Except to the extent the sale and remittance procedure
is utilized in connection with the option exercise, payment of the Exercise
Price must accompany the Notice of Exercise (or the Purchase Agreement)
delivered to the Corporation in connection with the option exercise.

                 (c)    As soon after the Exercise Date as practical, the
Corporation shall issue to or on behalf of Optionee (or any other person or
persons exercising this option) a certificate for the purchased Option Shares,
with the appropriate legends affixed thereto.  To the extent any such Option
Shares are unvested, the certificates for those Option Shares shall be
endorsed with an appropriate legend evidencing the Corporation's repurchase
rights and may be held in escrow with the Corporation until such shares vest.

                 (d)    In no event may this option be exercised for any
fractional shares.

           11.   NO IMPAIRMENT OF RIGHTS.  This Agreement shall not in any
way affect the right of the Corporation to adjust, reclassify, reorganize or
otherwise make changes in its capital or business structure or to merge,
consolidate, dissolve, liquidate or sell or transfer all or any part of its
business or assets.  In addition, this Agreement shall not in any way be
construed or interpreted so as to affect adversely or otherwise impair the
right of the Corporation or the stockholders to remove Optionee from the Board
at any time in accordance with the provisions of applicable law.

           12.   COMPLIANCE WITH LAWS AND REGULATIONS.

                 (a)    The exercise of this option and the issuance of the
Option Shares upon such exercise shall be subject to compliance by the
Corporation and Optionee with all applicable requirements of law relating
thereto and with all applicable regulations of any stock exchange (or the
Nasdaq National Market, if applicable) on which the Common Stock may be listed
for trading at the time of such exercise and issuance.

                 (b)    The inability of the Corporation to obtain approval
from any regulatory body having authority deemed by the Corporation to be
necessary to the lawful issuance and sale of any Common Stock pursuant to this
option shall relieve the Corporation of any liability with respect to the

                                   -5-

<PAGE>

non-issuance or sale of the Common Stock as to which such approval shall not
have been obtained.  The Corporation, however, shall use its best efforts to
obtain all such approvals.

           13.   SUCCESSORS AND ASSIGNS.  Except to the extent otherwise
provided in Paragraph 3 or 6, the provisions of this Agreement shall inure to
the benefit of, and be binding upon, the Corporation and its successors and
assigns and Optionee, Optionee's assigns and the legal representatives, heirs
and legatees of Optionee's estate.

           14.   NOTICES.  Any notice required to be given or delivered to
the Corporation under the terms of this Agreement shall be in writing and
addressed to the Corporation at its principal corporate offices.  Any notice
required to be given or delivered to Optionee shall be in writing and
addressed to Optionee at the address indicated below Optionee's signature line
on the Grant Notice.  All notices shall be deemed effective upon personal
delivery or upon deposit in the U.S. mail, postage prepaid and properly
addressed to the party to be notified.

           15.   CONSTRUCTION.  This Agreement and the option evidenced
hereby are made and granted pursuant to the Plan and are in all respects
limited by and subject to the terms of the Plan.

           16.   GOVERNING LAW.  The interpretation, performance and
enforcement of this Agreement shall be governed by the laws of the State of
California without resort to that State's conflict-of-laws rules.

                                   -6-

<PAGE>


                                 EXHIBIT I

                            NOTICE OF EXERCISE


           I hereby notify Advanced Tissue Sciences, Inc. (the "Corporation")
that I elect to purchase ___________ shares of the Corporation's Common Stock
(the "Purchased Shares") at the option exercise price of $______ per share 
(the "Exercise Price") pursuant to that certain option (the "Option") granted 
to me under the Corporation's 1997 Stock Incentive Plan on __________, 199__.

           Concurrently with the delivery of this Exercise Notice to the
Corporation, I shall hereby pay to the Corporation the Exercise Price for the
Purchased Shares in accordance with the provisions of my agreement with the
Corporation (or other documents) evidencing the Option and shall deliver
whatever additional documents may be required by such agreement as a condition
for exercise.  Alternatively, I may utilize the special broker-dealer sale and
remittance procedure specified in my agreement to effect payment of the
Exercise Price for any Purchased Shares in which I am vested at the time of
exercise of the Option.


___________________, 199__
Date

                                       ___________________________________
                                       Optionee

                                       Address:___________________________

                                       ___________________________________

Print name in exact manner
it is to appear on the
stock certificate:                     ___________________________________

Address to which certificate
is to be sent, if different
from address above:                    ___________________________________

                                       ___________________________________

Social Security Number:                ___________________________________

<PAGE>

                                  APPENDIX
                                  --------


     The following definitions shall be in effect under the Agreement:

     A.    AGREEMENT shall mean this Automatic Stock Option Agreement.

     B.    BOARD shall mean the Corporation's Board of Directors.

     C.    CHANGE IN CONTROL shall mean a change in ownership or control of
the Corporation effected through either of the following transactions:

                 (i)    the acquisition, directly or indirectly, by any person
     or related group of persons (other than the Corporation or a person that
     directly or indirectly controls, is controlled by, or is under common 
     control with, the Corporation) of beneficial ownership (within the 
     meaning of Rule 13d-3 of the 1934 Act) of securities possessing more 
     than fifty percent (50%) of the total combined voting power of the 
     Corporation's outstanding securities pursuant to a tender or exchange 
     offer made directly to the Corporation's stockholders which the Board 
     does not recommend such stockholders to accept, or

                 (ii)   a change in the composition of the Board over a period
     of twenty-four (24) consecutive months or less such that a majority of 
     the Board members ceases, by reason of one or more contested elections 
     for Board membership, to be comprised of individuals who either 
     (A) have been Board members continuously since the beginning of such 
     period or (B) have been elected or nominated for election as Board 
     members during such period by at least a majority of the Board members 
     described in clause (A) who were still in office at the time the Board
     approved such election or nomination.

     D.    CODE shall mean the Internal Revenue Code of 1986, as amended.

     E.    COMMON STOCK shall mean the Corporation's common stock.

     F.    CORPORATE TRANSACTION shall mean either of the following
stockholder-approved transactions to which the Corporation is a party:

                 (i)    a merger or consolidation in which securities
     possessing more than fifty percent (50%) of the total combined voting 
     power of the Corporation's outstanding securities are transferred to 
     a person or persons different from the persons holding those securities 
     immediately prior to such transaction, or

                                   A-1

<PAGE>

                 (ii)   the sale, transfer or other disposition of all or
     substantially all of the Corporation's assets in complete liquidation 
     or dissolution of the Corporation.     

     G.    CORPORATION shall mean Advanced Tissue Sciences, Inc., a Delaware
corporation.

     H.    EXERCISE DATE shall mean the date on which the option shall have
been exercised in accordance with Paragraph 10 of the Agreement.

     I.    EXERCISE PRICE shall mean the exercise price per share as 
specified in the Grant Notice.

     J.    EXPIRATION DATE shall mean the date on which the option expires 
as specified in the Grant Notice.

     K.    FAIR MARKET VALUE per share of Common Stock on any relevant date 
shall be determined in accordance with the following provisions:

                 (i)    If the Common Stock is at the time traded on the 
     Nasdaq National Market, then the Fair Market Value shall be the closing 
     selling price per share of Common Stock on the date in question, as the 
     price is reported by the National Association of Securities Dealers on 
     the Nasdaq National Market or any successor system.  If there is no 
     closing selling price for the Common Stock on the date in question, 
     then the Fair Market Value shall be the closing selling price on the 
     last preceding date for which such quotation exists.

                 (ii)   If the Common Stock is at the time listed on any 
     Stock Exchange, then the Fair Market Value shall be the closing selling 
     price per share of Common Stock on the date in question on the Stock 
     Exchange which serves as the primary market for the Common Stock, as 
     such price is officially quoted in the composite tape of transactions 
     on such exchange.  If there is no closing selling price for the Common 
     Stock on the date in question, then the Fair Market Value shall be the 
     closing selling price on the last preceding date for which such 
     quotation exists.

     L.    GRANT DATE shall mean the date of grant of the option as specified
in the Grant Notice.

     M.    GRANT NOTICE shall mean the Notice of Grant of Automatic Stock
Option accompanying the Agreement, pursuant to which Optionee has been
informed of the basic terms of the option evidenced hereby.

                                   A-2


<PAGE>


     N.    1934 ACT shall mean the Securities Exchange Act of 1934, as 
amended.

     O.    NON-STATUTORY OPTION shall mean an option not intended to satisfy 
the requirements of Code Section 422.

     P.    NOTICE OF EXERCISE shall mean the notice of exercise in the form 
of Exhibit I.

     Q.    OPTION SHARES shall mean the number of shares of Common Stock 
subject to the option.

     R.    OPTIONEE shall mean the person to whom the option is granted as 
specified in the Grant Notice.

     S.    PERMANENT DISABILITY shall mean the inability of Optionee to
perform his or her usual duties as a member of the Board by reason of any
medically determinable physical or mental impairment which is expected to
result in death or has lasted or can be expected to last for a continuous
period of twelve (12) months or more.

     T.    PLAN shall mean the Corporation's 1997 Stock Incentive Plan.

     U.    PURCHASE AGREEMENT shall mean the stock purchase agreement (in
form and substance satisfactory to the Corporation) which grants the
Corporation the right to repurchase, at the Exercise Price, any and all
unvested Option Shares held by Optionee at the time of Optionee's cessation 
of Board service and which precludes the sale, transfer or other disposition 
of any purchased Option Shares while those shares are unvested and subject to
such repurchase right.

     V.    STOCK EXCHANGE shall mean the American Stock Exchange or the New
York Stock Exchange.

     W.    VESTING SCHEDULE shall mean the vesting schedule specified in the
Grant Notice pursuant to which the Option Shares are to vest in a series of
installments over Optionee's period of Board service.

                                   A-3



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