ADVANCED TISSUE SCIENCES INC
8-K, 1998-02-09
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549


                                   FORM 8-K

                                --------------


                                CURRENT REPORT

  Pursuant to Section 13 or 15(d) of the Securities and Exchange Act of 1934


                               JANUARY 26, 1998
                                Date of Report
                       (Date of earliest event reported)

                                --------------



                        ADVANCED TISSUE SCIENCES, INC.
            (Exact name of registrant as specified in its charter)


                                --------------


         Delaware                    0-016607                   14-1701513
         --------                    --------                   ----------
(State or other jurisdiction of     (Commission              (I.R.S. Employer
 incorporation or organization)      File No.)              Identification No.)


     10933 North Torrey Pines Road, La Jolla, California          92037
     ---------------------------------------------------          -----
     (Address of principal executive offices)                   (Zip Code)


      Registrant's telephone number, including area code:  (619) 450-5730




<PAGE>


Item 5.  Other Events

On January 26, 1998, Advanced Tissue Sciences, Inc. (the "Company" or
"Advanced Tissue Sciences") and Hatteras Partners, L.P., formerly known as
Ramius Hatteras Partners, L.P. (the "Investor"), executed an amendment (the
"Amendment") to extend the term of an Investment Agreement between the parties
to February 9, 1999.  Advanced Tissue Sciences originally entered into the
Investment Agreement with the Investor in February 1996.  The Investment
Agreement provides for an equity line which allows the Company to access up to
$50 million through sales of its Common Stock.  The decision to draw any funds
under the Investment Agreement and the timing of any such draw is solely at
the Company's discretion.  Other than extending the term for an additional
year, the Amendment does not materially change the terms of the Investment
Agreement.

As a commitment fee for keeping the equity line available for an additional
year, the Company granted the Investor a warrant to purchase 50,000 shares of
Common Stock at an exercise price of $14.00 per share.  The warrant is
exercisable over a period of seven years.

The Amendment to the Investment Agreement between the Company and the Investor
dated January 26, 1998 is attached hereto as an exhibit and is incorporated
herein by reference.  The foregoing summary is qualified in its entirety by
reference to such exhibit.

Item 7.  Exhibits

 Exhibit
 Number                       Description
 -------                      -----------

  4.1        Amendment No. 1 to Investment Agreement between 
             Advanced Tissue Sciences, Inc. and Hatteras 
             Partners, L.P. (formerly Ramius Hatteras Partners,
             L.P.) dated January 26, 1998


                                  SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.




                                       ADVANCED TISSUE SCIENCES, INC.


Date:  February 6, 1998                By:   /s/ Arthur J. Benvenuto
                                          -----------------------------
                                          Arthur J. Benvenuto
                                          Chairman and Chief Executive Officer

<PAGE>


                                 EXHIBIT INDEX


 Exhibit
 Number                      Description                               Page
 -------                     -----------                               ----

  4.1        Amendment No. 1 to Investment Agreement between 
             Advanced Tissue Sciences, Inc. and Hatteras Partners, 
             L.P. (formerly Ramius Hatteras Partners, L.P.) dated  
             January 26, 1998








                                                                EXHIBIT 4.1



                   AMENDMENT NO. 1 TO INVESTMENT AGREEMENT


         This Amendment No. 1 to Investment Agreement (this "Amendment") is
made as of January 26, 1998 by and between Hatteras Partners, L.P., formerly
known as Ramius Hatteras Partners, L.P. (the "Investor") and Advanced Tissue
Sciences, Inc., a corporation organized and existing under the laws of the
State of Delaware (the "Company").

         WHEREAS, the Investor and the Company are parties to that certain
Investment Agreement (the "Investment Agreement") dated as of February 9, 1996
pursuant to which the Investor shall, upon the request of the Company, invest
up to $50,000,000 in the Company's Common Stock, par value $.01 per share (the
"Common  Stock");  and

         WHEREAS, pursuant to Section 1.2(a) of the Investment Agreement, the
Investment Agreement terminates on the earlier of February 9, 1998 or the
occurrence of certain specified events, and the Investor and the Company
desire to extend the term to February 9, 1999; and

         WHEREAS, in exchange for extending the term of the Investment
Agreement, the Company has agreed to grant the Investor a warrant to purchase
50,000 shares of Common Stock at an exercise price per share equal to the
average of the high and low sales prices for the Common Stock as reported on
the Nasdaq National Market on the date hereof (the "Warrant"), which Warrant
will contain a "cashless exercise" provision for the benefit of the Investor;
and

         WHEREAS, the Investor has agreed that in exchange for providing the
Investor a "cashless exercise" right under the Warrant and the inclusion of
certain "piggyback registration rights" in the Warrant, the Company shall not
otherwise be obligated to register for resale under the Securities Act of
1933, as amended (the "1933 Act"), the shares of Common Stock issuable upon
the exercise of the Warrant.

         NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties hereto agree as
follows:

         1.  Defined Terms.  Capitalized terms used but not defined herein
shall have the meanings ascribed to them in the Investment Agreement.

         2.  Amendment of Section 1.2(a) to Extend Term to February 9, 1999.    
The first sentence of Section 1.2(a) of the Investment Agreement is hereby  
restated to read as follows:

         "At any time prior to the earlier of (i) February 9, 1999 or 
         (ii) the termination of this Agreement in accordance with 
         Article V herein, the Company may deliver written notices 
         to the Investor (each such notice hereinafter referred to  
         as a "Put Notice") stating a dollar amount (the "Dollar  
         Amount") of Common Stock which the Company intends to sell 
         to the Investor five business days following the date (the 
         "Put Notice Date") on which the Put Notice is given to the 
         Investor by the Company in accordance with Section 6.4 herein."

                                   1

<PAGE>



         3.  Change in Name of Investor.  Any notice  or other communication 
sent by the Company to the Investor pursuant to the Investment Agreement or  
this Amendment shall be addressed to Hatteras Partners, L.P. (rather than to 
its former name, Ramius Hatteras Partners, L.P.).  All other information 
concerning how notices or other communications are to be sent to the Investor
shall remain unchanged as set forth in Section 5.2 of the Investment  
Agreement.

         4.  Issuance of Warrant; No Registration Requirement.  Concurrent
with the execution of this Amendment, the Company shall deliver to the
Investor the Warrant in the form attached hereto as Exhibit A executed by the
Company.  The Company shall not be required to register under the 1933 Act the
50,000 shares of Common Stock issuable upon the exercise of the Warrant (such
50,000 shares, the "New Warrant Shares"); thus, the provisions of Section 1.5
of the Investment Agreement shall not apply to the Warrant.

         5.  Remedy for Failure to Purchase from February 9, 1998 to
February 9, 1999.   The deliveries to be made by the Investor to the Company
under Section 6.1(b)(i), (ii) or (iii) of the Investment Agreement upon a
Failure to Purchase by the Investor shall apply only to a Failure to Purchase
that occurs through and including February 9, 1998.  In particular, none of
the 175,000 Warrant Shares underlying the Warrants issued upon execution of
the Investment Agreement shall be subject to forfeiture for a Failure to
Purchase that occurs from and after February 9, 1998 through and including
February 9, 1999 (the "Extension Period"), nor shall any of the 50,000 New
Warrant Shares underlying the Warrant issued concurrently with the execution
of this Amendment be subject to forfeiture for a Failure to Purchase that
occurs prior to the Extension Period.  The remedy for a Failure to Purchase
that occurs during the Extension Period shall be as set forth below in this
paragraph.  Upon a Failure to Purchase that occurs during the Extension
Period, the Investor shall promptly deliver to the Company, (i) that
percentage of the total number of New Warrant Shares as is equal to that
percentage of $50,000,000 which the Investor failed to deliver to the Company
at the time of the Failure to Purchase, or (ii) cash equal to 1/2% of the 
amount which the Investor failed to deliver to the Company at the time of the 
Failure to Purchase or (iii) Common Stock equal in value, based on the market 
value of such Common Stock on the date of such Failure to Purchase, to 1/2% 
of the amount which the Investor failed to deliver to the Company at the time 
of the Failure to Purchase.  The determination as to type of consideration to 
be delivered to the Company pursuant to the immediately preceding sentence 
shall be made by the Investor, in its sole discretion.  Nothing in this 
Section 5 is intended to limit or in any way be in lieu of any rights or 
remedies which the Company may have against Investor for any breach by 
Investor of the Investment Agreement, this Amendment or other agreements 
entered into pursuant to the Investment Agreement or this Amendment.

         6.  Balance of Investment Agreement Unaffected.  Except as
amended hereby, the Investment Agreement continues in full force and effect as
originally executed.

         7.  Entire Agreement.  This Amendment, together with the Investment 
Agreement, constitutes the entire agreement among the parties pertaining to 
the subject matter hereof and completely supersedes all prior or
contemporaneous agreements, understandings, arrangements, commitments,
negotiations and discussions of the parties, whether oral or written (all of
which shall have no substantive significance or evidentiary effect).  Each
party acknowledges,  

                                   2

<PAGE>


represents and warrants that it has not relied on any representation,  
agreement, understanding, arrangement or commitment which has not been  
expressly set forth in this Amendment and the Investment Agreement.  Each 
party acknowledges, represents and warrants that this Amendment, together
with the Investment Agreement, is fully integrated and not in need of parol
evidence in order to reflect the intentions of the parties.  The parties
specifically intend that the literal words of this Amendment and the
Investment Agreement shall, alone, conclusively determine all questions
concerning the parties' intent.

         8.  Counterparts.  This Amendment may be executed in one or more
counterparts, which, when taken together, shall constitute one and the same
instrument.

         IN WITNESS WHEREOF, the parties hereto have caused this Amendment to
be duly executed by their respective authorized officers as of the date first
above written.


                                         ADVANCED TISSUE SCIENCES, INC.


                                         By:_______________________________
                                         Name:_____________________________
                                         Title:____________________________



                                         HATTERAS PARTNERS, L.P.


                                         By:  Bertram  Capital,  LLC

                                         By:_______________________________
                                         Name:_____________________________
                                         Title:____________________________


                                   3



<PAGE>



                               EXHIBIT A

                            Form of Warrant

                              (Attached)





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