FIRST TRUST GNMA SERIES 42 SERIES 44 & SERIES 45
24F-2NT, 1994-02-15
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                                             February 15, 1994


Securities and Exchange Commission
450 5th Street, N.W.
Washington, D.C. 20549-1004

Re: Rule 24f-2 Notice for The First Trust GNMA Series 42,
    File No. 33-20247

Gentlemen:

As sponsor of The First Trust GNMA Series 42, we are
submitting the information required by Rule 24f-2 promulgated
under the investment Company Act of 1940, as amended. We also are
enclosing the opinion of counsel specified in paragraph (b)(1)(v)
of said Rule.  The filing fee indicated below has been, or will
be, sent by wire transfer to the SEC's account in payment of the
fee prescribed by paragraph (c) of said Rule.
(i)   Fiscal year for which notice is filed: Year ended 
      December 31, 1993
(ii)  Number of securities registered other than pursuant to
      Rule 24f-2 and remaining unsold at the beginning of the
      above fiscal year: 0
(iii) Number of securities registered other than pursuant to
      Rule 24f-2 during the above fiscal year: 0
(iv)  Number of securities sold during the above fiscal year:
      249.552
(v)   Number of securities sold in reliance upon registration
      pursuant to Rule 24f-2 during the above fiscal year*:
      249.552
___________________________________
(1)   Aggregate sales price to the public
      of securities sold in reliance upon
      registration pursuant to Rule 24f-2:       $149,259.95
(2)   Less actual aggregate redemption or
      repurchase price of securities during
      the fiscal year:                           $143,325.98
(3)   Plus actual aggregate redemption or
      repurchase price of securities 
      previously applied in filings pursuant
      to Section 24(e)(1):                             -0- 

                                                 $  5,933.97
                            
       Amount of filing fee computed at one
       twenty-nineth of one percent (1/29 of 1%)
       of above total:                           $       2.05

 Very truly yours,

 Nike Securities L.P.

 By                  
   Carlos E. Nardo
   Senior Vice President




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