COPLEY PHARMACEUTICAL INC
SC 13G/A, 1999-02-16
PHARMACEUTICAL PREPARATIONS
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                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549


                                 SCHEDULE 13G
                                        

                   Under the Securities Exchange Act of 1934
                           (Amendment No.    6    )*
                                         ---------      
                                        
                          Copley Pharmaceutical, Inc.
- --------------------------------------------------------------------------------
                               (Name of Issuer)

                    Common Stock, $.01 par value per share
- --------------------------------------------------------------------------------
                        (Title of Class of Securities)

                                  21745K-10-1
                      -----------------------------------
                                (CUSIP Number)

     *The remainder of this cover page shall be filled out for a reporting
     person's initial filing on this form with respect to the subject class of
     securities, and for any subsequent amendment containing information which
     would alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not be
     deemed to be "filed" for the purpose of Section 18 of the Securities
     Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
     that section of the Act but shall be subject to all other provisions of the
     Act (however, see the Notes).


                              Page 1 of 10 Pages
<PAGE>
 
- --------------------------                          --------------------------
  CUSIP NO.  21745K-10-1             13G             Page  2   of  10  Pages
           -------------                                 -----    -----
- --------------------------                          --------------------------
 
- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS.
 1    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                                                                                
      Jane C.I. Hirsh
                          
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* 
 2                                                              (a) [_]
                                                                (b) [_]
                                                 
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3
 

- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4                                 
      United States

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5                                                       
     NUMBER OF            0       
 
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6       
                          1,404,563
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7       
    REPORTING             0
 
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8       
                          1,404,563

- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9                           

      1,404,563 
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10    
                                                                    [_]
 
- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11           
      7.32%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON* 
12           
      IN

- ------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!


                              Page 2 of 10 Pages
 
<PAGE>
 
- --------------------------                          --------------------------
  CUSIP NO.  21745K-10-1            13G              Page  3   of  10  Pages
           -------------                                 -----    -----
- --------------------------                          --------------------------
 
- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS.
 1    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON 
                                                                                
      Mark Hirsh
                          
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* 
 2                                                              (a) [_]
                                                                (b) [_]
                                                 
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3
 

- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4                                 
      United States

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5                                                       
     NUMBER OF            0       
 
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6       
                          1,404,563
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7       
    REPORTING             0
 
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8       
                          1,404,563

- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9                           

      1,404,563 
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10    
                                                                    [_]
 
- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11           
      7.32%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON* 
12           
      IN

- ------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!


                              Page 3 of 10 Pages
<PAGE>
 
- --------------------------                          --------------------------
  CUSIP NO.  21745K-10-1            13G              Page  4   of  10  Pages
           -------------                                 -----    -----
- --------------------------                          --------------------------
 
- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS.
 1    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                                                                                
      Theodore L. Iorio
                          
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* 
 2                                                              (a) [_]
                                                                (b) [_]
                                                 
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3
 

- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4                                 
      United States

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5                                                       
     NUMBER OF            1,126,473       
 
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6       
                          260,073
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7       
    REPORTING             1,126,473       
 
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8       
                          260,073

- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9                           

      1,386,546
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10    
                                                                    [_]
 
- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11           
      7.17%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON* 
12           
      IN

- ------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!


                              Page 4 of 10 Pages
<PAGE>
 
Item 1 (a).    Name of Issuer:
- -----------    ---------------

               Copley Pharmaceutical, Inc.
Inc.
Item 1 (b).    Address of Issuer's Principal Executive Offices:
- -----------    ------------------------------------------------

               25 John Road
               Canton, MA 02021

Item 2 (a).    Name of Person Filing:
- -----------    ----------------------
 
               Jane C.I. Hirsh, Mark Hirsh, Theodore L. Iorio

Item 2 (b).    Address of Principal Business Office or, if none, Residence:
- -----------    ------------------------------------------------------------

               The principal business address of Jane C.I. Hirsh, Mark Hirsh and
               Theodore L. Iorio is Copley Pharmaceutical, Inc., 25 John Road,
               Canton, MA 02021.

Item 2 (c).    Citizenship:
- -----------    ------------
               United States citizens

Item 2 (d).    Title of Class of Securities:
- -----------    -----------------------------

               Common Stock, $.01 par value per share

Item 2 (e).    CUSIP Number
- -----------    ------------

               21745K-10-1

Item 3.        If this statement is filed pursuant to Rules 13d-1(b), or
- -------        ---------------------------------------------------------
               13d-2(b), check whether the person filing is a:
               -----------------------------------------------

               (a)  [  ]  Broker or dealer registered under Section 15 of the 
                          Act.
 
               (b)  [  ]  Bank as defined in Section 3(a)(6) of the Act.
 
               (c)  [  ]  Insurance Company as defined in Section 3(a) (19) 
                          of the Act.
 
               (d)  [  ]  Investment Company registered under Section 8 of the
                          Investment Company Act.

               (e)  [  ]  Investment Adviser registered under Section 203 of 
                          the Investment Advisers Act of 1940.
 
               (f)  [  ]  Employee Benefit Plan, Pension Fund which is subject
                          to the provisions of the Employee Retirement Income
                          Security Act of 1974 or Endowment Fund; see 13d-1 (b)
                          (1) (ii) (F).
                                                                   
                              Page 5 of 10 Pages
<PAGE>
 
               (g)  [  ]  Parent Holding Company, in accordance with Rule 
                          13d-1(b) (ii) (G); see Item 7.
 
               (h)  [  ]  Group, in accordance with Rule 13d-1 (b) (1) (ii) (H).
 


Item 4.        Ownership:
- -------        ----------

               (a)  Amount Beneficially Owned:

                    Jane C.I. Hirsh is the record owner of 112,500 shares (which
                    number includes 112,500 options exercisable within 60 days
                    of 12/31/98.) Ms. Hirsh may be deemed to beneficially own
                    25,321 shares and 7,757 shares which are allocated to
                    herself and her spouse, Mark Hirsh, respectively, in the
                    Copley Pharmaceutical, Inc. Employee Stock Ownership Plan.
                    By virtue of her status as the spouse of Mark Hirsh, Ms.
                    Hirsh may be deemed to beneficially own 170,569 shares which
                    Mark Hirsh owns in his capacity as the General Partner of
                    Romeo Partners. Ms. Hirsh may be deemed to beneficially own
                    888,416 shares in Copley Pharmaceutical, Inc. by virtue of
                    her status as the general partner of Juliet Partners. Ms.
                    Hirsh may be deemed to be the beneficial owner of 200,000
                    shares by virtue of her status as a general partner in NMJ
                    Limited Partnership. Therefore, Ms. Hirsh may be deemed to
                    beneficially own 1,404,563 shares of Common Stock. Ms. Hirsh
                    expressly disclaims beneficial ownership of shares of Common
                    Stock held of record by Mark Hirsh, Romeo Partners and/or
                    allocated in the Copley Pharmaceutical, Inc. Employee Stock
                    Ownership Plan to Mark Hirsh.

                    Mark Hirsh may be deemed to beneficially own 25,321 shares
                    and 7,757 shares which are allocated to his spouse, Jane
                    C.I. Hirsh, and himself, respectively, in the Copley
                    Pharmaceutical, Inc. Employee Stock Ownership Plan.  By
                    virtue of his status as the spouse of Jane C.I. Hirsh, Dr.
                    Hirsh may be deemed to beneficially own 112,500 shares of
                    Common Stock which are individually owned by Jane C.I. Hirsh
                    (which number includes 112,500 options exercisable within 60
                    days of 12/31/98) and 888,416 which Jane Hirsh owns in her
                    capacity as the general partner of Juliet Partners.  Dr.
                    Hirsh may be deemed to beneficially own 170,569 shares by
                    virtue of his status as the general partner of Romeo
                    Partners.  Dr. Hirsh may be deemed to beneficially own
                    200,000 shares by virtue of his status as general partner in
                    NMJ Limited Partnership.  Therefore, Dr. Hirsh may be deemed
                    to be the beneficial owner of 1,404,563 shares of Common
                    Stock.  Dr. Hirsh expressly disclaims beneficial ownership
                    of shares of Common Stock held of record by Jane C.I. Hirsh,
                    Juliet Partners and/or allocated in the Copley
                    Pharmaceutical, Inc. Employee Stock Ownership Plan to Jane
                    C.I. Hirsh.

                    Theodore L. Iorio is the record owner of 286,885 shares
                    (which number includes 150,605 options exercisable within 60
                    days of 12/31/98).  Additionally, Mr. Iorio may be deemed to
                    beneficially own: 163,932 shares which are held of record by
                    the Theodore L. Iorio Charitable Remainder Trust; 653,454
                    shares which are held of record by the Theodore L. Iorio
                    Standard Trust; and 22,202 shares allocated to Mr. Iorio in
                    the Copley Pharmaceutical, Inc. Employee Stock Ownership
                    Plan.  


                              Page 6 of 10 Pages
<PAGE>
 
                    Also includes 260,073 shares held by trusts for the benefit
                    of certain members of Mr. Iorio's family, for which Mr.
                    Iorio's disclaims. Therefore Mr. Iorio may be deemed to be
                    the beneficial owner of 1,386,546 shares of Common Stock.
                    Mr. Iorio expressly disclaims beneficial ownership of shares
                    of Common Stock held of record by the Iorio Family
                    Foundation and the Theodore L. Iorio Charitable Remainder
                    Trust.

               (b)  Percent of Class:

                    Jane C.I. Hirsh, Mark Hirsh, and Theodore L. Iorio may be
                    deemed to beneficially own 7.32%, 7.32% and 7.17%
                    respectively (based on the 19,188,351 shares of Common Stock
                    reported to be outstanding on October 31, 1998 in the Copley
                    Pharmaceutical, Inc. Quarterly Report on Form 10-Q for the
                    fiscal quarter ended 9/30/98.)

               (c)  Number of Shares as to which such person has:

                    (i)  sole power to vote or to direct the vote:
                         Jane C.I. Hirsh              0
                         Mark Hirsh                   0
                         Theodore L. Iorio            1,126,473

                    (ii) shared power to vote or to direct the vote:
                         Jane C.I. Hirsh              1,404,563
                         Mark Hirsh                   1,404,563
                         Theodore L. Iorio            260,073
 
                   (iii) sole power to dispose or to direct the disposition of:
                         Jane C.I. Hirsh              0
                         Mark Hirsh                   0
                         Theodore L. Iorio            1,126,473

                    (iv) shared power to dispose or to direct the disposition 
                         of:
                         Jane C.I. Hirsh              1,404,563
                         Mark Hirsh                   1,404,563
                         Theodore L. Iorio            260,073

Item (5).      Ownership of Five Percent or Less of a Class:
- ---------      ---------------------------------------------

               Not Applicable.

Item (6).      Ownership of More than Five Percent On Behalf of Another Person:
- ---------      ----------------------------------------------------------------

               Not Applicable.

Item (7).      Identification and Classification of the Subsidiary Which
- ---------      ---------------------------------------------------------
               Acquired the Security Being Reported on by the Parent Company:
               --------------------------------------------------------------

               Not Applicable.  This statement is not filed pursuant to 13d-1(b)
               (ii) (G).


                              Page 7 of 10 Pages
<PAGE>
 
Item (8).      Identification and Classification of Members of the Group:
- ---------      ----------------------------------------------------------
               Not Applicable.  This statement is not filed pursuant to 13d-1(b)
               (ii) (H).

Item (9).      Notice of Dissolution of Group:
- ---------      -------------------------------

               Not Applicable.

Item (10).     Certification:
- ----------     --------------

               Not Applicable.  This statement is not filed pursuant to Rule
               13d-1(b).





                              Page 8 of 10 Pages
<PAGE>
 
                                   SIGNATURE
                                        
  After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Dated:  February 5, 1999
                                  
                                   /s/ Jane C.I. Hirsh
                                  -------------------------------
                                  Jane C.I. Hirsh


                                   /s/ Mark Hirsh
                                  -------------------------------
                                  Mark Hirsh


                                   /s/ Theodore L. Iorio
                                  -------------------------------
                                  Theodore L. Iorio




                              Page 9 of 10 Pages
<PAGE>
 
                                   EXHIBIT I
                                   ---------


          Pursuant to Rule 13d-1(f)(1) under the Securities Exchange Act of
1934, the undersigned hereby agree only one statement containing the information
required on Amendment No. 6 to Schedule 13G need be filed with respect to
ownership by each of the undersigned of shares of Common Stock of Copley
Pharmaceutical, Inc.

          This Agreement may be executed in any number of counterparts, each of
which shall be deemed an original.


Dated:  February 5, 1999
                                   /s/ Jane C.I. Hirsh
                                  -------------------------------
                                  Jane C.I. Hirsh


                                   /s/ Mark Hirsh
                                  -------------------------------
                                  Mark Hirsh


                                   /s/ Theodore L. Iorio
                                  -------------------------------
                                  Theodore L. Iorio

 




                              Page 10 of 10 Pages


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