BOSTON BIOMEDICA INC
DEFS14A, 1999-04-30
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
                                (Amendment No. )

Filed by the Registrant [X]

Filed by a Party other than the Registrant  [ ]

Check the appropriate box:
[ ]   Preliminary Proxy Statement
[ ]   Confidential,  for Use of the  Commission  Only  (as  permitted  by Rule
      14a-6(e)(2))  
[X]   Definitive  Proxy  Statement  
[ ]   Definitive Additional Materials  
[ ]   Soliciting Material Pursuant  to ss.240.14a-11(c) or ss.240.14a-12


                           BOSTON BIOMEDICA, INC.                               
- --------------------------------------------------------------------------------
              (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------
     (Name of Person(s) Filing Proxy Statement if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):
[X]   No fee required.
[ ]   Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

      1)    Title of each class of securities to which transaction applies:
            --------------------------------------------------------------------

      2)    Aggregate number of securities to which transaction applies:
            --------------------------------------------------------------------

      3)    Per unit price or other  underlying  value of  transaction  computed
            pursuant to Exchange  Act Rule 0-11.  (Set forth the amount on which
            the  filing  fee is  calculated  and state  how it was  determined):
            --------------------------------------------------------------------

      4)    Proposed maximum aggregate value of transaction:
            --------------------------------------------------------------------

      5)    Total fee paid:
            ---------- ---------------------------------------------------------

[ ]   Fee paid previously with preliminary materials.

[ ]   Check box if any part of the fee is offset as provided  by Exchange  Act
      Rule  0-11(a)(2)  and identify the filing for which the offsetting fee was
      paid  previously.  Identify the previous filing by registration  statement
      number, or the Form or Schedule and the date of its filing.

      1)    Amount Previously Paid:
            --------------------------------------------------------------------

      2)    Form, Schedule or Registration Statement No.:
            --------------------------------------------------------------------

      3)    Filing Party:
            --------------------------------------------------------------------

      4)    Date Filed:
            --------------------------------------------------------------------

<PAGE>


                             BOSTON BIOMEDICA, INC.

     Notice of Special Meeting in Lieu of Annual Meeting of Stockholders of
                      Boston Biomedica, Inc. to be held on
                                  July 20, 1999

      The Special  Meeting in Lieu of Annual Meeting of  Stockholders  of BOSTON
BIOMEDICA,  INC.  will be held on  Tuesday,  July 20,  1999 at 4:00 p.m.  at the
Company's headquarters,  375 West Street, West Bridgewater,  Massachusetts,  for
the following purposes:

1.    To elect two Class III  Directors  to hold  office  until the 2002  Annual
      Meeting of  Stockholders  and until a  successor  or  successors  are duly
      elected and qualified.

2.    To consider  and act upon a proposal to amend the Boston  Biomedica,  Inc.
      Employee Stock Option Plan.

3.    To consider  and act upon a proposal to adopt the Boston  Biomedica,  Inc.
      1999 Nonqualified Stock Option Plan.

4.    To consider  and act upon a proposal to adopt the Boston  Biomedica,  Inc.
      1999 Employee Stock Purchase Plan.

5.    To consider and act upon any matters  incidental to the foregoing  purpose
      and any other  matters  which may properly  come before the Meeting or any
      adjourned session thereof.

      The  Board of  Directors  has fixed May 25,  1999 as the  record  date for
determining the stockholders entitled to notice of, and to vote at, the Meeting.

      You are cordially invited to attend the Meeting.

                                              By Order of the Board Of Directors


                                              Candice J. Kobyluck,
                                              Clerk

Boston, Massachusetts
June 8, 1999

                             YOUR VOTE IS IMPORTANT

You are urged to sign, date and promptly return the accompanying  form of Proxy,
so that, if you are unable to attend the Meeting,  your shares may  nevertheless
be voted. However, the proxy is revocable as described in the proxy statement.


<PAGE>

                             BOSTON BIOMEDICA, INC.

                                 PROXY STATEMENT

                FOR THE SPECIAL MEETING IN LIEU OF ANNUAL MEETING
                           OF STOCKHOLDERS TO BE HELD
                                ON JULY 20, 1999


      This proxy statement is furnished in connection  with the  solicitation of
proxies by the Board of Directors  of Boston  Biomedica,  Inc., a  Massachusetts
corporation  with its  principal  executive  offices  at 375 West  Street,  West
Bridgewater, Massachusetts 02379 (referred to hereinafter as the "Company"), for
use at the Special  Meeting in Lieu of Annual Meeting of Stockholders to be held
on  July  20,  1999,  and  at  any  adjournment  or  adjournments  thereof  (the
"Meeting"). The enclosed proxy relating to the Meeting is solicited on behalf of
the Board of Directors of the Company and the cost of such  solicitation will be
borne  by the  Company.  It is  expected  that  this  proxy  statement  and  the
accompanying  proxy  will be mailed to  stockholders  on or about  June 8, 1999.
Certain of the officers and regular employees of the Company may solicit proxies
by  correspondence,  telephone or in person,  without  extra  compensation.  The
Company may also pay to banks,  brokers,  nominees and certain other fiduciaries
their  reasonable   expenses  incurred  in  forwarding  proxy  material  to  the
beneficial owners of securities held by them.

      Only  stockholders of record at the close of business on May 25, 1999 will
be entitled to receive notice of, and to vote at, the Meeting.  As of that date,
there were outstanding and entitled to vote xxxxxxx shares of Common Stock, $.01
par value,  of the  Company  (the  "Common  Stock").  Each such  stockholder  is
entitled  to one vote for each  share of Common  Stock so held and may vote such
shares either in person or by proxy.

      The enclosed proxy, if executed and returned, will be voted as directed on
the proxy or, in the absence of such direction, for the election of the nominees
as Directors,  for the amendment of the Boston  Biomedica,  Inc.  Employee Stock
Option Plan, for the adoption of the Boston  Biomedica,  Inc. 1999  Nonqualified
Stock  Option  Plan and for the  adoption  of the Boston  Biomedica,  Inc.  1999
Employee  Stock  Purchase  Plan. If any other matters shall properly come before
the Meeting,  the enclosed proxy will be voted by the proxies in accordance with
their best  judgment.  The proxy may be revoked at any time prior to exercise by
filing with the Clerk of the Company a written revocation,  by executing a proxy
with a later date, or by attending and voting at the Meeting.

                                       1

<PAGE>
                                 PROPOSAL NO. 1
                              ELECTION OF DIRECTORS

      At the Meeting,  two Class III  Directors are to be elected to serve until
the 2002 Annual Meeting of Stockholders and until a successor or successors have
been duly elected and qualified.

      The Company's  Amended and Restated  Articles of  Organization  and Bylaws
provide that the Board of Directors shall be divided into three classes. At each
Annual  Meeting  of  Stockholders  following  the  initial  classification,  the
Directors  elected to succeed  those whose terms expire shall be  identified  as
being the same class as the Directors  they succeed and shall be elected to hold
office for a term to expire at the third Annual  Meeting of  Stockholders  after
their  election,  and until their  respective  successors  are duly  elected and
qualified,  unless an  adjustment  in the term to which an  individual  Director
shall be elected is made because of a change in the number of Directors.

      The Board of  Directors  increased  the number of  Directors to six during
March,  1999 in accordance with the Company's  Amended and Restated  Articles of
Organization  which  authorizes the Board of Directors to change the number from
time to time, and appointed  William R. Prather as a new Class II Director.  The
term of Richard T.  Schumacher and Kevin W. Quinlan  expire at the Meeting.  Mr.
Schumacher  and Mr.  Quinlan  have been  renominated  for  election as Class III
Directors,  to hold office  until the 2002 Annual  Meeting of  Stockholders  and
until their successor or successors have been duly elected and qualified.

      It is the  intention  of the  persons  named  as  proxies  to vote for the
election  of Mr.  Schumacher  and Mr.  Quinlan  as Class III  Directors.  In the
unanticipated  event that either nominee should be unable to serve,  the persons
named as proxies will vote the proxy for such substitute, if any, as the present
Board of  Directors  may  designate  or to reduce the number of  Directors.  The
nominees have not been nominated  pursuant to any  arrangement or  understanding
with any person.

      The  following  table sets forth certain  information  with respect to the
nominees  and each of the  Directors  whose term  extends  beyond  the  Meeting,
including the year in which the nominee's term would expire, if elected.

<TABLE>
<CAPTION>
                                                                                  Director      Year  Term  Expires,
Name                                  Age    Position                             Since         if Elected, and Class
- ----                                  ---    --------                             -----         ---------------------
<S>                                  <C>    <C>                                  <C>           <C> 
Francis E. Capitanio (2)              54     Director                             1986          2000
                                                                                                Class I

Calvin A. Saravis (1)(2)              68     Director                             1978          2000
                                                                                                Class I

Henry A. Malkasian (1)                81     Director                             1978          2001
                                                                                                Class II

</TABLE>

                                       2




<TABLE>
<CAPTION>

<S>                                   <C>   <C>                                  <C>           <C>
William R. Prather, R.Ph, MD          52     Senior Vice President, Business      1999          2001
                                             Development and Director                           Class II
Kevin W. Quinlan, CPA (2)*            49     Senior Vice President, Finance;      1978          2002
                                             Chief Financial Officer; Treasurer                 Class III
                                             and Director

Richard T. Schumacher (1)*            48     President; Chief Executive Officer   1978          2002
                                             and Chairman of the Board                          Class III
</TABLE>

- --------------------
*    Nominee for Class III Director.
    (1)  Member of the Compensation Committee
    (2)  Member of the Audit Committee

      Mr. Capitanio has served as a Director since January 1986. Since 1997, Mr.
Capitanio  has served as President  of Kalisto  Biologicals,  Inc.  From 1996 to
1997,  he  served  as an  independent  consultant  in  the  medical  diagnostics
industry.  From 1980 to 1996, he served as President,  Treasurer and Director of
Diatech  Diagnostics  Inc.  (formerly  Immunotech  Corporation),   an  in  vitro
diagnostics  company and a wholly owned  subsidiary of  Healthcare  Technologies
Ltd.  Mr.  Capitanio  received an M.B.A.  from the Sloan  School of  Management,
Massachusetts   Institute  of  Technology   and  a  B.S.  in   metallurgy   from
Massachusetts Institute of Technology.

      Dr. Saravis has served as a Director  since 1978.  Since 1984, he has been
an Associate  Professor of Surgery  (biochemistry) at Harvard Medical School and
an Associate  Research  Professor of  Pathology at Boston  University  School of
Medicine.  From 1971 to 1997, Dr. Saravis was a Senior Research Associate at the
Mallory  Institute of Pathology and from 1979 to 1997, he was a Senior  Research
Associate at the Cancer Research  Institute--New England Deaconess Hospital. Dr.
Saravis received his Ph.D. in immunology and serology from Rutgers University.

      Mr.  Malkasian has served as a Director  since 1978.  Mr.  Malkasian is an
attorney-at-law  and a member of the firm  Malkasian,  Hicinbothem  & Mollica in
Massachusetts. He received his J.D. degree from Harvard University School of Law
and a B.A. degree from Clark University.

      Dr. Prather joined the Company in January,  1999 as Senior Vice President,
Business  Development,  and was  appointed  to the Board of  Directors in March,
1999.  From 1992 to 1995,  Dr. Prather was the Senior Analyst in Health Care for
Manning and Napier Advisors and from 1995 to 1998, he was the Senior Health Care
Analyst for Cruttenden  Roth, Inc. Dr. Prather earned a B.S. in pharmacy and his
MD at the  University  of  Missouri  - Kansas  City,  and  completed  a Clinical
Research Geriatric Fellowship at Harvard Medical School.

      Mr.  Quinlan,  a Director of the Company since 1978,  has been Senior Vice
President, Finance, Treasurer, and Chief Financial Officer since 1993. From 1990
to 1992, he was the Chief Financial  Officer of ParcTec,  Inc., a New York-based
leasing company. Mr. Quinlan 

                                       3

<PAGE>

served as Vice President and Assistant Treasurer of American Finance Group, Inc.
from 1981 to 1989 and was employed by Coopers & Lybrand  from 1975 to 1980.  Mr.
Quinlan is a certified public  accountant and received a M.S. in accounting from
Northeastern  University  and a B.S. in  economics  from the  University  of New
Hampshire.

      Mr. Schumacher, the founder of the Company, has been President since 1986,
and Chief Executive  Officer and Chairman since 1992. Mr.  Schumacher  served as
the Director of Infectious Disease Services for Clinical Sciences Laboratory,  a
New England-based medical reference laboratory,  from 1986 to 1988. From 1972 to
1985, Mr. Schumacher was employed by the Center for Blood Research,  a nonprofit
medical  research   institute   associated  with  Harvard  Medical  School.  Mr.
Schumacher received a B.S. in zoology from the University of New Hampshire.

Meetings of the Board of Directors

      The Board of Directors of the Company held four meetings during the fiscal
year ended December 31, 1998. Each current Director attended at least 75% of the
aggregate  number of all meetings of the Board of Directors  and  committees  of
which he was a member during such fiscal year.

      The Board of  Directors  has an Audit  Committee,  currently  comprised of
Messrs. Capitanio,  Quinlan and Saravis, which met once during fiscal year 1998.
The functions  performed by this Committee include  recommending to the Board of
Directors the engagement of the independent accountants,  reviewing the scope of
internal   controls  and   reviewing   the   implementation   by  management  of
recommendations made by the independent accountants.

      The  Board of  Directors  also  has a  Compensation  Committee,  currently
comprised  of  Messrs.  Schumacher,  Saravis  and  Malkasian.  The  Compensation
Committee met twice during fiscal year 1998.  The functions of the  Compensation
Committee  include  making  recommendations  and  presentations  to the Board of
Directors on compensation levels, including salaries,  incentive plans, benefits
and overall  compensation,  for  officers  and  Directors  and issuance of stock
options to officer, Directors and employees.

      The Board of Directors  does not have a nominating  committee.  Changes in
Directors are considered by the entire Board of Directors.

                                       4

<PAGE>


Security Ownership of Directors, Officers and Certain Beneficial Owners

        The following table sets forth certain  information as of March 26, 1999
concerning  the  beneficial  ownership  of Common Stock by each  Director,  each
nominee for Director,  each named Executive Officer in the Summary  Compensation
Table under "Executive  Compensation,"  below, all named Executive  Officers and
Directors as a group,  and each person known by the Company to be the beneficial
owner of 5% or more of the Company's  Common Stock.  This  information  is based
upon information received from or on behalf of the named individuals.

<TABLE>
<CAPTION>
                                                                           Number of Shares of
                                                                        Common Stock Beneficially
                                Name *                                            Owned              Percent of Class

<S>                                                                     <C>                          <C>   
Richard T. Schumacher(1)(2)........................................               1,018,897                20.98%
   c/o Boston Biomedica, Inc.
   375 West Street
   West Bridgewater, MA  02379
Henry A. Malkasian(1)(3)...........................................                 313,310                 6.62%
   c/o Malkasian, Hicinbothem & Mollica
   Framingham Executive Park
   40 Speen Street
   Framingham, MA  01701
Kevin W. Quinlan, CPA(1)...........................................                  94,850                 1.98%
Richard C. Tilton, Ph.D.(1)........................................                  64,375                 1.35%
William R. Prather, R.Ph, MD (1)(5)................................                  58,300                 1.23%
Mark M. Manak, Ph.D.(1)(4).........................................                  56,675                 1.19%
Patricia E. Garrett, Ph.D.(1)......................................                  49,875                 1.05%
Barry M. Warren(1).................................................                  33,375                  **
Calvin A. Saravis, Ph.D.(1)........................................                  10,956                  **
Francis E. Capitanio(1)............................................                   2,500                  **
All Executive Officers and Directors as a group                              
(10 Persons)(1)(2)(3)(4)(5)........................................               1,703,113                35.40%
Irwin J. Gruverman(6)..............................................                 378,510                 8.01%
   c/o G & G Diagnostics Limited Partnerships I, II and III
   30 Ossipee Road
   Newton, MA  02164
</TABLE>
- ------------

*    Address provided for beneficial owners of more than 5% of the Common Stock.
**   Less than 1% of the outstanding Common Stock.

(1)   Includes the following  shares  subject to options  exercisable  within 60
      days after March 26, 1999:  Mr.  Schumacher -- 138,690;  Mr.  Malkasian --
      12,500; Mr. Quinlan -- 71,250; Dr. Tilton -- 38,375; Dr. Prather -- 5,000,
      Dr. Manak -- 38,375;  Dr.  Garrett -- 25,875,  Mr.  Warren -- 33,375;  Dr.
      Saravis -- 10,956; and Mr. Capitanio -- 2,500.

(2)   Includes  50,000  shares  held of record by Mr.  Schumacher's  spouse  and
      20,000  shares  held of  record by Mr.  Schumacher  as  custodian  for his
      daughter.  Excludes certain  additional  shares held by other relatives of
      Mr. Schumacher as to which Mr. Schumacher disclaims beneficial ownership.


                                       5
<PAGE>


(3)   Includes 12,000 shares held of record by Mr. Malkasian's son, 5,000 shares
      held by Mr.  Malkasian's  daughter,  53,150 shares held by Mr. Malkasian's
      spouse and 30,000  shares  held by Mr.  Malkasian  as trustee in trust for
      each of his son and his daughter.

(4)   Includes  4,000 shares held of record by Mr.  Manak as  custodian  for his
      daughter.

(5)   Includes 53,300 shares held by Avon Medical Profit Sharing Plan and Trust.
      Dr. Prather and his spouse are the sole trustees and  beneficiaries of the
      trust.

(6)   Includes  355,593 shares held of record by three limited  partnerships  of
      which Mr. Gruverman is the general partner and 10,000 fully vested options
      held by Mr. Gruverman.

Executive Compensation

        The following Summary  Compensation Table sets forth the compensation of
each of the Chief  Executive  Officers and the other  Executive  Officers of the
Company who were serving as Executive Officers at the end of fiscal year 1998.

                           Summary Compensation Table
                           --------------------------

<TABLE>
<CAPTION>
                                                       Annual Compensation                                  Long Term
                                                       -------------------                                Compensation   All Other
                                                 Fiscal                                                   ------------
          Name and                                Year         Salary        Bonus      Other Annual         Options    Compensation
     Principal Position                          Ended          ($)           ($)       Compensation          (#)          ($)
- ------------------------------------------      --------      --------      --------      --------         --------      --------

<S>                                             <C>           <C>           <C>           <C>                <C>         <C>        
Richard T. Schumacher, ...................      12/31/98      $200,002      $  5,000      $    370(1)        15,000      $    420(2)
  President,  Chief ......................      12/31/97       194,616          --           2,008(1)          --            --
  Executive Officer and ..................      12/31/96       193,502          --           2,008(1)         5,000          --
  Chairman of the Board

Kevin W. Quinlan, CPA ....................      12/31/98      $143,347      $  4,000          --             10,000          --
  Senior Vice President, .................      12/31/97       139,927          --            --               --            --
  Finance, Treasurer, ....................      12/31/96       133,772          --            --              5,000          --
  Chief Financial Officer
  and Director

Barry M. Warren ..........................      12/31/98      $137,601      $  3,000          --              6,000          --
  Senior Vice President, .................      12/31/97       129,367          --            --               --            --
  Sales & Marketing ......................      12/31/96       123,671          --            --             22,500          --

Richard C. Tilton, Ph.D ..................      12/31/98      $127,019      $  3,000      $  6,000(3)         6,000          --
  Senior Vice President, .................      12/31/97       121,164          --           6,000(3)          --            --
  Specialty Laboratory ...................      12/31/96       106,197          --           6,000(3)         2,500          --
  Services

Mark M. Manak, Ph.D ......................      12/31/98      $118,510      $  3,000          --              6,000          --
  Senior Vice President, .................      12/31/97       116,388          --            --               --            --
  Research & .............................      12/31/96       111,058          --            --              2,500          --
  Development

Patricia E. Garrett, Ph.D ................      12/31/98      $108,787      $  3,000          --              6,000          --
  Senior Vice President, .................      12/31/97       106,188          --            --               --            --
  Regulatory Affairs & ...................      12/31/96       100,966          --            --              2,500          --
  Strategic Programs
</TABLE>
- --------

(1)      Consists of personal usage of Company vehicle
(2)      Includes the value of premiums paid for a term life, insurance policy.
(3)      Consists of automobile allowance

                                       6
<PAGE>


      The  following  table shows stock options  granted to the named  Executive
Officers in fiscal 1998:

<TABLE>
<CAPTION>
                                        Options Granted in Fiscal Year 1998

                                                    Individual Grants                            Potential Realizable Value
                                                                                                             at
                               ------------------------------------------------------------
                                 Number of        % of Total                                       Assumed Annual Rates of
                                Securities          Options                                       Stock Price Appreciation
                                Underlying        Granted to      Exercise                       for Option Term at Year End
                                                                  ----------    -----------     ------------------------------
                                  Options          Employees      Price         Expiration
            Name                  Granted           in 1998        ($/Sh.)         Date              5%             10%
            ----
                               --------------     ------------    ---------- -- -----------     ------------- ----------------
<S>                            <C>               <C>              <C>          <C>              <C>              <C>    
Richard T. Schumacher                 15,000            4.88%         $3.25        4/14/08           $30,659          $77,695
Kevin W. Quinlan, CPA                 10,000            3.26%          3.25        4/14/08            20,439           51,797
Barry M. Warren                        6,000            1.95%          3.25        4/14/08            12,263           31,078
Richard C. Tilton, Ph.D.               6,000            1.95%          3.25        4/14/08            12,263           31,078
Mark M. Manak, Ph.D.                   6,000            1.95%          3.25        4/14/08            12,263           31,078
Patricia E. Garrett, Ph.D.             6,000            1.95%          3.25        4/14/08            12,263           31,078
</TABLE>

      The following  table shows stock options  exercised by the named Executive
Officers  during  fiscal 1998,  including  the  aggregate  value  realized  upon
exercise.  This represents the excess of the fair market value over the purchase
price at the time of purchase.  In addition,  this table  includes the number of
shares underlying both "exerciseable" (i.e. vested) and  "unexerciseable"  (i.e.
unvested) stock options as of December 31, 1998. Also reported are the values of
"in-the-money"  options,  which reflect the positive spread between the exercise
price of any such  existing  stock  options and the  closing  year end per share
price of the Common Stock of $2.96875.

<TABLE>
<CAPTION>
                                        Aggregated Option Exercises in Last
                                   Fiscal Year and Fiscal Year End Option Values

                               Shares                            Number of Securities             Value of Unexercised
                                Acquired                        Underlying Unexercised            In-the-Money Options
                                   on         Value (1)          Options at Year End                  at Year End
                                                              ---------------------------      ---------------------------
            Name                Exercise       Realized       Exercisable  Unexercisable       Exercisable  Unexercisable
                               -----------    -----------     ------------ --------------      ------------ --------------
<S>                            <C>            <C>             <C>          <C>                 <C>          <C> 
Richard T. Schumacher              --             --              138,690         13,690          $220,963      $275
Kevin W. Quinlan, CPA              --             --               71,250          8,750            50,469       --
Barry M. Warren                    --             --               33,375         10,125                --       --
Richard C. Tilton, Ph.D.           --             --               38,375          5,125                --       --
Mark M. Manak, Ph.D.               --             --               38,375          5,125            16,406       --
Patricia E. Garrett, Ph.D.       10,000        $50,000             25,875          5,125            32,875       --
</TABLE>
- -------------------
(1) Based  upon the  closing  price of the Common  Stock on the Nasdaq  National
Market on the date of exercise, minus the respective option exercise price.

                                       7

<PAGE>


Report on Stock Option Repricing Amendment

      On December 11, 1998,  the Board  determined  that certain  stock  options
issued to  employees  and  consultants  of the  Company  had an  exercise  price
significantly  higher than the market value of the Company's  Common  Stock.  In
light of the  Board's  conclusions  that such  options  were not  providing  the
desired  incentive,  the Board provided  employees with the opportunity to amend
options  previously granted to them (the "Amended Options") to purchase the same
number of shares of Common  Stock at an  exercise  price of $3.25 per  share,  a
premium  over the then fair  market  value of the Common  Stock.  Employees  and
consultants  were given the choice of accepting the amendment,  maintaining  the
original vesting  schedule,  but with a one year moratorium,  on the exercise of
vested amended options,  in effect until December 11, 1999, or maintaining their
existing  options with no moratorium.  The Company  amended  options to purchase
411,417 shares of Common Stock with an original  weighted average exercise price
of $6.72 per share.

The following table sets forth  information  concerning stock options which have
been amended for the Company's Executive Officers:


<TABLE>
<CAPTION>
                                                        Market                            Length of
                                             Number     Price of   Exercise              Option Term
                                               of       Stock at   Price at     New       Remaining
                                             Options    Time of     Time of   Exercise    at Date of
            Name                     Date    Amended   Amendment   Amendment   Price      Amendment
- -----------------------------    ---------- --------- ----------- ---------- ---------- -------------
<S>                                <C>         <C>      <C>          <C>         <C>        <C>    
Richard T. Schumacher              02/28/96    5,000    $2.5625      $7.00       $3.25      7 years
                                   04/14/98   15,000     2.5625       6.25        3.25      9 years
Kevin W. Quinlan, CPA              02/28/96    5,000     2.5625       7.00        3.25      7 years
                                   04/14/98   10,000     2.5625       6.25        3.25      9 years
Barry M. Warren                    11/08/93   15,000     2.5625       4.50        3.25      4 years
                                   02/28/96   22,500     2.5625       7.00        3.25      7 years
                                   04/14/98    6,000     2.5625       6.25        3.25      9 years
Richard C. Tilton, Ph.D.           02/28/96    2,500     2.5625       7.00        3.25      7 years
                                   04/14/98    6,000     2.5625       6.25        3.25      9 years
Mark M. Manak, Ph.D.               02/28/96    2,500     2.5625       7.00        3.25      7 years
                                   04/14/98    6,000     2.5625       6.25        3.25      9 years
Patricia E. Garrett, Ph.D.         11/08/93    2,500     2.5625       4.50        3.25      4 years
                                   02/28/96    2,500     2.5625       7.00        3.25      7 years
                                   04/14/98    6,000     2.5625       6.25        3.25      9 years
</TABLE>

                                    Compensation Committee

                                    Richard T. Schumacher
                                    Henry A. Malkasian
                                    Calvin A. Saravis

Compensation of Directors

      Directors  of the  Company  do not  receive  cash  compensation  for their
services.  Each Director has been eligible to receive options to purchase Common
Stock under the Company's

                                       8
<PAGE>

1987 Non-Qualified Stock Option Plan which expired in December,  1997. The Board
of  Directors  has  adopted,  subject  to  stock  holder  approval,  the  Boston
Biomedica,  Inc.  1999  Nonqualified  Stock  Option  Plan,  See  Proposal No. 3,
"Adoption of the Company's 1999 Nonqualified Stock Option Plan".

Compensation Committee Interlocks and Insider Participation

      Decisions  regarding  executive  compensation  are  made by the  Board  of
Directors  based  on the  recommendations  of the  Compensation  Committee.  The
Compensation  Committee  of the Board of  Directors  is  comprised of Richard T.
Schumacher,  Henry A. Malkasian and Calvin A. Saravis, each of whom has received
options to purchase  Common Stock.  Mr.  Schumacher  serves as the President and
Chief  Executive  Officer of the  Company.  Messrs.  Malkasian  and  Saravis are
neither former nor current officers or employees of the Company.

Compensation Committee Report

      The  Compensation  Committee of the Board of Directors is comprised of Mr.
Schumacher and two non-employee  Directors,  Messrs.  Malkasian and Saravis. The
functions of the  Compensation  Committee  include  making  recommendations  and
presentations  to the  Board of  Directors  on  compensation  levels,  including
salaries,  incentive plans,  benefits and overall  compensation for officers and
Directors  and issuance of stock options to officers,  Directors and  employees.
The Compensation  Committee  determines the compensation to be paid to the Chief
Executive Officer and each of the other Executive Officers of the Company.

      The objectives of the  Compensation  Committee in determining the type and
amount  of  Executive  Officer  compensation  are to  provide  a  level  of base
compensation which allows the Company to attract and retain superior talent. The
Compensation Committee endeavors to align the Executive Officer's interests with
the success of the Company through participation in the Company's Employee Stock
Option Plan, which provides the Executive  Officer with the opportunity to build
a substantial ownership interest in the Company.

      The compensation of Executive  Officers  includes cash  compensation,  the
grant of stock options and participation in benefit plans generally available to
employees.  In determining  base salary,  the Compensation  Committee  considers
executive  compensation for comparably sized companies as well as the individual
experience and performance of each Executive Officer. The Compensation Committee
sets  base  salaries  at  a  level  that  it  believes  is  comparable  to  cash
compensation  of officers with similar  responsibilities  in similarly  situated
corporations.

      Each  of  the  Executive  Officers,  including  Mr.  Schumacher,  and  all
full-time  employees  are  eligible  to  receive  grants  of  options  under the
Company's  Employee Stock Option Plan. The Employee Stock Option Plan is used to
provide  incentives to officers and employees and to associate  more closely the
interests of such persons with stockholders' interests and the long-term success
of the  Company.  In  determining  the  number of  options to be granted to each
Executive  Officer or employee,  the  Compensation  Committee makes a subjective
determination based on factors such as the individual's level of responsibility,
performance, and number of

                                       9

<PAGE>

options held.  During fiscal 1998, a total of 49,000 options were granted to the
named Executive Officers under the Employee Stock Option Plan.

      During the fiscal  year ended  December  31,  1998,  Mr.  Schumacher,  the
Company's  Chief  Executive  Officer,  received a base salary of  $200,002.  The
Compensation Committee believes that this compensation is comparable to the cash
compensation of chief Executive Officers of comparable companies. Mr. Schumacher
was  granted  options to  purchase a total of 17,380  shares of Common  Stock in
1998.

                                    Compensation Committee

                                    Richard T. Schumacher
                                    Henry A. Malkasian
                                    Calvin A. Saravis


                                       10

<PAGE>


Performance Graph

      The following graph compares the change in the Company's  cumulative total
shareholder return from October 31, 1996, when the Company's Common Stock became
publicly  traded,  to March 31, 1999,  including  December  31,  1998,  the last
trading day of fiscal 1998, with the cumulative total return on the NASDAQ Stock
Market Index (U.S. Companies) and the NASDAQ  Pharmaceuticals  Stocks Index (SIC
2830-2839 U.S. and Foreign) for that period.

                               [Performance Graph]


                                     Legend

<TABLE>
<CAPTION>
Symbol    Index Description
- ------    -----------------
                                     10/31/96 12/31/96 3/31/97 6/30/97 9/30/97 12/31/97 3/31/98 6/30/98 9/30/98 12/31/98 3/31/99
                                     -------- -------- ------- ------- ------- -------- ------- ------- ------- -------- -------
<S>      <C>                         <C>      <C>      <C>     <C>     <C>     <C>      <C>     <C>     <C>     <C>      <C> 
_____[]   Boston Biomedica, Inc.        100.0     87.1   122.6   109.7    93.5     71.0    90.0    69.0    32.0     38.0    44.0
- -----/\   Nasdaq Stock Market           100.0    106.1   100.4   118.7   138.8    130.2   152.0   156.0   141.0    183.0   205.0
            (U.S. Companies)
_ _ _ o   Nasdaq Pharmaceuticals        100.0    101.6    96.5   104.2   116.9    104.9   116.0   107.0   101.0    134.0   147.0
          Stocks (SIC 2830-2839 U.S.
             & Foreign)
</TABLE>


Assumes $100  invested on October 31, 1996 in the Company's  Common  Stock,  the
Nasdaq Stock Market Index (U.S. Companies) and the Nasdaq Pharmaceuticals Stocks
Index  (SIC  2830-2839  U.S. &  Foreign),  and the  reinvestment  of any and all
dividends.

                                       11

<PAGE>


Certain Relationships And Related Transactions

      The Company is a party to a Registration  Rights  Agreement  dated June 5,
1990, as amended (the "Registration  Agreement"),  with G&G Diagnostics  Limited
Partnership I and G&G  Diagnostics  Limited  Partnership  II  (together,  "G&G")
pursuant  to which G&G has  certain  rights to have its  shares of Common  Stock
registered by the Company under the Securities Act. A total of 355,593 shares of
Common Stock (the "Registrable  Shares") held by G&G or subject to warrants held
by G&G may be  registered  under  the  Registration  Agreement.  If the  Company
proposes to register any of its securities  under the Securities Act, either for
its own account or for the account of other securityholders,  G&G is entitled to
notice of the registration and is entitled to include, at the Company's expense,
the  Registrable  Shares therein,  provided,  among other  conditions,  that the
underwriters  have the right to limit the number of such shares  included in the
registration. In addition, G&G may require the Company at its expense on no more
than two occasions,  to file a registration  statement  under the Securities Act
with respect to its Registrable  Shares,  and the Company is required to use its
best efforts to effect such a  registration,  subject to certain  conditions and
limitation.  Further, G&G may require the Company at its expense to register the
Registrable  Shares  on Form S-3 when  such form is  available  to the  Company,
subject to certain conditions and limitations.

                                       12

<PAGE>


                                 PROPOSAL NO. 2
                   AMENDMENT OF THE EMPLOYEE STOCK OPTION PLAN

      The Board of Directors has approved,  subject to stockholder  approval, an
amendment  to the Boston  Biomedica,  Inc.  Employee  Stock  Option  Plan,  (the
"Employee  Stock Option  Plan") to increase the number of shares of Common Stock
which may be issued upon exercise of options  granted  under the Employee  Stock
Option Plan from 1,500,000 shares to 2,000,000 shares.

Summary of the Employee Stock Option Plan

      The following is a summary  description  of the Employee Stock Option Plan
and is qualified in its entirety by reference to the text of the Employee  Stock
Option Plan which is set forth as Exhibit A to this proxy statement.

      Purpose.  The  purpose of the  Employee  Stock  Option  Plan is to provide
increased  incentives to employees of the Company to remain  affiliated with the
Company,  to  promote  the  success  of the  Company's  business,  to  encourage
prospective  employees  to become  affiliated  with the Company and to associate
more closely the interests of such persons with those of the Company through the
granting of options to acquire the capital stock of the Company.

      Administration.  The  Employee  Stock  Option  Plan is  administered  by a
committee (the  "Committee")  which consists solely of two or more  non-employee
Directors as provided in Rule 16b-3  promulgated  under the Securities  Exchange
Act of 1934, as amended.

      Subject to the express  provisions of the Employee  Stock Option Plan, the
Committee has the authority and sole  discretion to determine those employees of
the Company to whom options may be granted under the Employee Stock Option Plan,
the number of shares  covered by an option and the terms and  conditions  of the
options to be granted,  and the time or times when the options are granted.  The
Committee  also has  authority  to alter any  restrictions  or  conditions  upon
options,  adopt rules and regulations,  and make all other determinations deemed
necessary or desirable for the administration of the Employee Stock Option Plan.

      Eligible  Participants.  Options under the Employee  Stock Option Plan may
only be granted to those  employees of the Company who are employed a minimum of
20 hours per week. Currently,  227 of the Company's  approximately 264 employees
are eligible to receive grants of options under the Employee Stock Option Plan.

      Shares  Subject  to the  Employee  Stock  Option  Plan.  If  the  proposed
amendment is approved by the  stockholders at the Meeting,  a total of 2,000,000
shares of Common  Stock will be issuable  upon  exercise  of options  granted or
which may be granted under the Employee  Stock Option Plan. The shares of Common
Stock to be issued upon  exercise of options  granted  under the Employee  Stock
Option Plan may include, at the discretion of the Board of Directors, authorized
but unissued shares,  shares  previously  reserved for issuance upon exercise of
options which have expired or been terminated or treasury shares.  If any option
granted  under the  Employee  Stock Option Plan  expires or  terminates  for any
reason without having been exercised

                                       13

<PAGE>

in full, the remaining  shares covered thereby will be available for grant under
additional options under the Employee Stock Option Plan. As of 3/31/99,  options
to purchase  955,887  shares of Common Stock had been granted under the Employee
Stock Option Plan.

      Stock Options. The Committee may grant either stock options which meet the
requirements  of Section 422 of the Internal  Revenue Code of 1986,  as amended,
("incentive  stock  options")  or  stock  options  which  are not  qualified  as
incentive stock options ("non-qualified stock options").

      Limitation  on Grant of Options.  The  aggregate  fair market value of the
Common Stock (determined as of the time of the grant of any option designated as
an  incentive  stock  option by the  Committee)  with  respect to which  options
designated as incentive  stock options are  exercisable  for the first time by a
holder  during any  calendar  year,  under all plans of the  Company,  providing
incentive stock options, may not exceed $100,000.

      Option  Price.  The  price at which  any  shares  of  Common  Stock may be
purchased pursuant to the exercise of an option granted under the Employee Stock
Option Plan is fixed by the Committee but may not be less than par value. In the
case of an incentive  stock option,  the purchase price may not be less than the
fair market  value of the Common  Stock on the date of grant of the options (or,
in the case of  holders  of at least  10% of the  Company's  outstanding  Common
Stock,  110% of the fair  market  value on such  date),  without  regard  to any
restrictions  other  than  those  restrictions  which by their  terms will never
lapse. The closing price of the Company's Common Stock on 3/31/99 was $3.375.

      Exercise of Options.  Each option  granted under the Employee Stock Option
Plan will  continue  in effect  for such  period  as the  Committee  determines,
provided  that  no  incentive  stock  option,  or  installment  thereof,  may be
exercisable  subsequent to ten years from the date of grant (five years from the
date of  grant in the  case of  options  issued  to 10%  stockholders).  Options
granted under the Employee  Stock Option Plan  generally vest over a period of 4
years.  No option may be  exercisable  beyond  three  months after the date upon
which the option holder ceases to be an employee of the Company, except that the
Committee  may  provide  in the  option  that in the  event  of  termination  of
employment by reason of death or permanent  and total  disability of the holder,
the option may be  exercised  by the holder of his or her estate for a period of
up to one year after  termination of  employment.  The Committee may provide for
the  termination  of  any  option  upon   termination  of  the  option  holder's
affiliation with the Company.

      At the discretion of the Committee, any options granted under the Employee
Stock Option Plan may be subject to restrictions  on vesting or  transferability
or to risk of  forfeiture  upon  the  happening  of  such  events  as the as the
Committee  may  determine,  any of which  may be  accelerated  or  waived in the
Committee's sole  discretion.  The purchase price for the shares of Common Stock
must be paid in full  upon  exercise  and may be paid in cash,  by  delivery  of
shares  of  Common  Stock or any  combination  of cash and  Common  Stock as the
Committee may permit.

                                       14
<PAGE>



      Transfer Restrictions.  An option is exercisable only by the holder during
his or her  lifetime,  and no  option  or  right or  interest  in an  option  is
assignable or  transferable  by the holder except by will or the laws of descent
and distribution.

      Changes  in  Common  Stock.  If the  Company  is a  party  to any  merger,
consolidation,  purchase of property or stock,  separation or  reorganization or
liquidation,  the Board of  Directors  (or if the  Company is not the  surviving
corporation,  the  board of  Directors  of the  surviving  corporation)  has the
authority to make arrangements, which will be binding on option holders, for the
substitution  of new options for, or the assumption by another  corporation  of,
any options then outstanding under the Employee Stock Option Plan.

      If  by  reason  of   recapitalization,   reclassification,   stock  split,
combination of shares,  or dividend on the Common Stock payable in Common Stock,
the  outstanding  shares of Common  Stock are  increased or decreased or changed
into or exchanged for a different  number or kind of shares or other  securities
of  the  Company,  the  Board  of  Directors  will  conclusively  determine  the
appropriate  adjustment in the exercise prices of outstanding options and in the
number and kind of shares as to which outstanding options will be exercisable.

      In the event of any of the  foregoing  transactions,  the total  number of
shares of Common stock on which options may be granted under the Employee  Stock
Option Plan will be appropriately adjusted by the Board of Directors.

      Indemnity.  Neither  the Board of  Directors  nor the  Committee,  nor any
members of either, nor any employees of the Company shall be liable for any act,
omission,  interpretation,  construction or determination  made in good faith in
connection with their responsibilities under the Employee Stock Option Plan. The
Company  has agreed to  indemnify  the  members of the Board of  Directors,  the
members of the  Committee  and the  employees  of the  Company in respect of any
claim,  loss, damage or expense  (including  counsel fees) arising from any such
act, omission, interpretation,  construction or determination to the full extent
permitted by law.

      Amendment, Termination and Duration of the Employee Stock Option Plan. The
Board of Directors  may amend,  suspend or terminate  the Employee  Stock Option
Plan in whole or in part.  The Board of Directors may not,  however,  materially
increase the benefits accruing to option holders,  increase the number of shares
of Common Stock reserved for issuance pursuant to the Employee Stock Option Plan
or materially  modify the requirements to be a participant in the Employee Stock
Option Plan without  stockholder  approval.  Except as otherwise provided in the
Employee  Stock Option Plan, no  amendment,  suspension  or  termination  of the
Employee  Stock Option Plan may affect the rights of any option  holder  without
such option holder's  consent.  The Employee Stock Option Plan will terminate on
March 29, 2004.  No option may be granted  under the Employee  Stock Option Plan
thereafter, but such termination will not affect the validity of options granted
prior to the date of termination.

      Federal Tax Consequences.  The following general discussion of the Federal
income tax  consequences  of the issuance and exercise of options  granted under
the  Employee  Stock  Option Plan is based upon the  provisions  of the Internal
Revenue Code as in effect on the date of this

                                       15

<PAGE>

proxy  statement  (the "Code"),  current  regulations  thereunder,  and existing
administrative rulings of the Internal Revenue Service. It is not intended to be
a complete  discussion of all of the Federal income tax consequences of Employee
Stock  Option Plan or of the  requirements  that must be met in order to qualify
for the described tax treatment.  Changes in the law and  regulations may modify
the discussion, and in some cases the changes may be retroactive. No information
is  provided as to the state tax laws.  The  Employee  Stock  Option Plan is not
qualified  under Section 401 of the Code and is not subject to the provisions of
the Employee Retirement Income Security Act of 1974, as amended.

      Incentive  Stock Options  under the Employee  Stock Option Plan. An option
holder generally will not recognize  taxable income upon either the grant or the
exercise of an incentive  stock option.  However,  under certain  circumstances,
there may be  alternative  minimum tax or other tax  consequences,  as discussed
below.

      Assuming a gain, an option holder will  recognize  taxable income upon the
disposition of the shares of Common Stock received upon exercise of an incentive
stock  option.   Any  gain  recognized   upon  a  disposition   that  is  not  a
"disqualifying  disposition"  (as defined  below)  will be taxable as  long-term
capital gain.

      A  "disqualifying  disposition"  means any disposition of shares of Common
Stock acquired on the exercise of an incentive  stock option within two years of
the date the stock  option was granted or within one year of the date the shares
were transferred to the option holder.  The use of the shares acquired  pursuant
to the exercise of an incentive  stock option to pay the option  exercise  price
under  another  incentive  stock  option is  treated as a  disposition  for this
purpose. In general, if an option holder makes a disqualifying  disposition,  an
amount equal to the excess of (i) the lesser of (a) the fair market value of the
shares  on the date of  exercise  or (b) the  amount  actually  realized  on the
disposition  over (ii) the option  exercise  price  will be taxable as  ordinary
income and the balance of the gain recognized, if any, will be taxable as either
long-term or short-term  capital gain,  depending on the option holder's holding
period for the shares.  In the case of a gift or certain  other  transfers,  the
amount of  ordinary  income  taxable to the option  holder is not limited to the
amount of gain which would be recognized in the event of a sale.  Instead, it is
equal to the  excess  of the fair  market  value  of the  shares  on the date of
exercise over the option exercise price.

      Certain  option  holders  are  generally  subject to Section  16(b) of the
Securities  Exchange Act of 1934 ("Section  16(b)") upon their sale of shares of
Common Stock.  This may affect their tax liability if they make a  disqualifying
disposition of shares acquired on exercise of an incentive  stock option.  If an
option holder subject to Section 16(b) makes a  disqualifying  disposition,  the
date on  which  the  fair  market  value  of the  shares  is  determined  may be
postponed.  The IRS  regulations  have not yet been  amended to conform with the
most recent revision to Section 16(b). However, it is generally anticipated that
the date on which  the  fair  market  value of the  shares  is  determined  (the
"Determination  Date") will be the earlier of (i) the date six months  after the
date the stock  option was granted  or, if earlier,  (ii) the first day on which
the sale of the shares  would not  subject the  individual  to  liability  under
Section  16(b).  It is possible  that the six month period will instead run from
the option holder's most recent grant or

                                       16

<PAGE>


purchase of common  Stock prior to his or her exercise of the stock  option.  On
the  Determination  Date,  the option holder will generally  recognize  ordinary
taxable  income in an amount equal to the excess of the fair market value of the
shares of Common Stock at that time over the option exercise price.  Despite the
general rule, if there is a disqualifying disposition and the Determination Date
is after the date of exercise,  the option holder may make an election  pursuant
to  Section  83(b) of the Code in which case the option  holder  will  recognize
ordinary taxable income at the time the stock option is exercised and not on the
later date. In order to be effective,  the 83(b) election must be made and filed
with the IRS within 30 days after exercise.

      In general,  in the year of  exercise of an  incentive  stock  option,  an
option  holder must  compute  the excess of the fair market  value of the shares
issued upon  exercise  over the  exercise  price and include  this amount in the
calculation of his or her alternative minimum taxable income. The application of
the alternative  minimum tax rules for an option holder subject to Section 16(b)
or who receives shares that are not "substantially  vested" are more complex and
may depend upon whether the holder makes a Section 83(b) election,  as described
above.  Because of the many  adjustments  that apply to the  computation  of the
alternative  minimum tax, it is not possible to predict the  application  of the
tax to  any  particular  option  holder.  However,  an  option  holder  may  owe
alternative  minimum tax even though he or she has not disposed of the shares or
otherwise received any cash with which to pay the tax, and with the enactment of
the Taxpayer Relief Act of 1997, the alternative  minimum tax rate is now higher
than the rate applicable to long-term gains.

      The  Company  will not be entitled to any  deduction  with  respect to the
grant or exercise of an incentive  stock option  provided the option holder does
not  make  a  disqualifying  disposition.  If  the  option  holder  does  make a
disqualifying disposition, the Company will generally be entitled to a deduction
for  Federal  income  tax  purposes  in an amount  equal to the  taxable  income
recognized by the option  holder,  provided the Company  reports the income on a
timely provided and filed Form W-2.

      Non-Qualified  Stock  Options  under the Employee  Stock Option Plan.  The
recipient of a  non-qualified  stock option under the Employee Stock Option Plan
will not recognize  any taxable  income at the time the stock option is granted.
Upon  exercise,  the option holder will  generally  recognize  ordinary  taxable
income in an amount  equal to the excess of the fair market  value of the shares
of Common Stock received on the date of exercise over the option exercise price.
Upon a subsequent  sale of the shares,  long-term or short-term  capital gain or
loss (depending  upon the holding period) will generally be recognized  equal to
the excess of the  difference  between the amount  realized over the fair market
value of the shares on the date of exercise.

      The Company will  generally be entitled to a  compensation  deduction  for
Federal income tax purposes in an amount equal to the taxable income  recognized
by the  option  holder,  provided  the  Company  reports  the income on a timely
provided and filed Form W-2 or 1099, whichever is applicable.

      Cashless Exercise. An option holder who pays the option exercise price, in
whole or in part, by  delivering  shares of Common Stock already owned by him or
her will generally

                                       17
<PAGE>


recognize  no gain  or loss  for  Federal  income  tax  purposes  on the  shares
surrendered, but otherwise will be taxed according to the rules described above.
As noted above,  if shares received on the exercise of an incentive stock option
are used within the time periods that apply to a disqualifying disposition, then
the rules for  disqualifying  dispositions,  described above, will apply. To the
extent  the  shares  acquired  upon  exercise  are equal in number to the shares
surrendered,  the basis and holding period of the shares  received will be equal
to the basis and holding period of the shares  surrendered,  plus the income, if
any,  recognized in the case of any applicable  disqualifying  disposition.  The
basis of the shares received in excess of the shares  surrendered  upon exercise
will be equal to the fair  market  value of the shares on the date of  exercise,
and the holding period for the shares received will commence on that date.

Vote Required to Amend the Employee Stock Option Plan

      The affirmative  vote of a majority of holders of the Common Stock present
in person or by proxy at the Meeting is required for adoption of Proposal No. 2.

      The Board of Directors  recommends that  stockholders vote FOR approval of
Proposal No. 2.


                                       18
<PAGE>


                                 PROPOSAL NO. 3
                            ADOPTION OF THE COMPANY'S
                       1999 NONQUALIFIED STOCK OPTION PLAN

      The Board of Directors has adopted,  subject to stockholder approval,  the
Boston Biomedica, Inc. 1999 Nonqualified Stock Option Plan (the "1999 Plan").

Summary of the 1999 Plan

      The following is a summary  description  of the 1999 Plan and is qualified
in its  entirety by reference to the text of the 1999 Plan which is set forth as
Exhibit B to this proxy statement.

      Purpose.  The purpose of the 1999 Plan is to attract and retain employees,
Directors,  advisors and consultants and provide an incentive for them to assist
the  Company to achieve  long-range  performance  goals,  and to enable  them to
participate in the long-term growth of the Company.

      Administration.  The 1999 Plan will be  administered  by the  Compensation
Committee of the Board of  Directors,  or such other  committee of not less than
two members of the Board of  Directors  appointed  by the Board of  Directors to
administer the 1999 Plan (the "Committee").

      Subject to the express provisions of the 1999 Plan, the Board of Directors
has the  authority  to  adopt,  alter  and  repeal  such  administrative  rules,
guidelines  and  practices  governing the operation of the 1999 Plan as it shall
from time to time consider  advisable,  and to interpret  the  provisions of the
1999 Plan. To the extent permitted by applicable law, the Board of Directors may
delegate to the Committee the power to make awards to  participants  in the 1999
Plan and all determinations under the 1999 Plan with respect thereto.

      Eligible  Participants.  Options  under  the 1999 Plan may be  granted  to
employees,  Directors,  advisers  and  consultants  of the  Company,  capable of
contributing  significantly  to  the  successful  performance  of  the  Company.
Currently, 225 of the Company's approximately 270 employees, Directors, advisers
and  consultants  would be eligible to receive  grants of options under the 1999
Plan.

      Shares  Subject  to the 1999  Plan.  Subject to  stockholder  approval,  a
maximum of 500,000  shares of Common Stock will be available for issuance  under
the 1999 Plan.  The shares of Common Stock to be  delivered  under the 1999 Plan
may be authorized but unissued shares,  shares previously  reserved for issuance
upon  exercise of options  which have  expired or been  terminated,  or treasury
shares.  If any option  granted  under the 1999 Plan expires or terminates or is
forfeited for any reason  without  having been  exercised in full, the remaining
shares covered thereby will be available for future grants under the 1999 Plan.

      Stock  Options.  Subject to the provisions of the 1999 Plan, the Committee
may award  options to purchase  shares of Common Stock which are not intended to
comply as incentive

                                       19

<PAGE>


stock options under the requirements of Section 422 of the Internal Revenue Code
of 1986, as amended ("nonqualified stock options").

      Option  Price.  The  price at which  any  shares  of  Common  Stock may be
purchased pursuant to the exercise of an option granted under the 1999 Plan will
be fixed by the Committee at the time each option is awarded.  The closing price
of the Company's Common Stock on 3/31/99 was $3.375.

      Exercise of Options. Each option granted under the 1999 Plan will continue
in effect for such period as the  Committee  determines,  and will be subject to
such terms and conditions as the Committee may specify in the  applicable  award
or  thereafter.  The  Committee may impose such  conditions  with respect to the
exercise of options,  including  conditions  relating to  applicable  Federal or
state  securities  laws, as it considers  necessary or advisable.  The Committee
will  determine  the  effect  on an  option  awarded  under the 1999 Plan of the
disability,  death,  retirement or other  termination of employment of an option
holder and the extent to which, and the period during which, the option holder's
legal representative,  guardian or designated beneficiary may receive payment of
an option awarded under the 1999 Plan or exercise rights thereunder.

      The  purchase  price for the  shares of Common  Stock must be paid in full
upon  exercise  and may be paid in whole or in part in cash  or,  to the  extent
permitted by the Committee at or after the award of the option, by delivery of a
note or share of Common  Stock owned by the  optionholder,  valued at their fair
market value on the date of delivery,  by the  reduction of the shares of Common
Stock that the option  holder would be entitled to receive upon  exercise of the
option,  such  shares  to be valued at their  fair  market  value on the date of
exercise, less their option price (a "cashless exercise"),  or such other lawful
consideration as the Committee may determine. In addition, the option holder may
engage in a successive  exchange (or series of exchanges) in which the shares of
Common Stock that such option holder is entitled to receive upon the exercise of
an option may be  simultaneously  utilized  as payment  for the  exercise  of an
additional option or options.

      Changes  in  Common  Stock.  In the  event  that the  Board  of  Directors
determines that any stock dividend,  extraordinary cash dividend,  creation of a
class  of   equity   securities,   recapitalization,   reorganization,   merger,
consolidation,  split-up, spin-off, combination, exchange of shares, warrants or
rights  offering to purchase  Common Stock at a price  substantially  below fair
market value, or other similar transaction affects the Common Stock such that an
adjustment  is required in order to preserve the benefits or potential  benefits
intended to be made available  under the 1999 Plan,  then the Board of Directors
shall equitably adjust any or all of the number and kind of shares in respect of
which  option  awards may be made  under the 1999  Plan,  the number and kind of
shares  subject  to  outstanding  option  awards,  and the  award,  exercise  or
conversion  price  with  respect  to any  of  the  foregoing.  In  addition,  if
appropriate,  the Board of Directors may make  provision for a cash payment with
respect  to an  outstanding  option  award,  provided  that the number of shares
subject to any option awarded under the 1999 Plan must always be a whole number.

                                       20

<PAGE>

      Change in Control.  In order to preserve a  participant's  rights under an
award,  in event of a change of  control  of the  Company,  a  Committee  in its
discretion may, at the time an award is made or at any time thereafter, take one
or more of the following  actions (i).  Provide for the acceleration of any time
period relating to the exercise of the award,  (ii.) provide for the purchase of
an award upon the participant's  request for an amount of cash or other property
that could have been  received  upon the  exercise  of the award,  had the award
currently  been  exercisable,  (iii)  adjust  the terms of the award in a manner
determined by the Committee to reflect the change in control,  (iv) to cause the
award to be assumed, or new rights substituted therefore,  by another entity, or
(v) make such other  provisions as the  Committee may consider  equitable and in
the best interest of the Company.

      Indemnity.  Neither  the Board of  Directors  nor the  Committee,  nor any
members of either,  nor any employees of the Company will be liable for any act,
omission,  interpretation,  construction or determination  made in good faith in
connection  with their  responsibilities  with  respect  to the 1999  Plan.  The
Company  has agreed to  indemnify  the  members of the Board of  Directors,  the
members of the  Committee  and the  employees  of the  Company in respect of any
claim, loss, damage or expense (including  reasonable counsel fees) arising from
any such act,  omission,  interpretation,  construction or  determination to the
full extent permitted by law.

      Amendment,  Termination  and  Duration  of the  1999  Plan.  The  Board of
Directors may amend, suspend or terminate the 1999 Plan in whole or in part. Any
amendments to the 1999 Plan will, however, be subject to stockholder approval to
the extent  required by the Internal  Revenue Code of 1986, as amended form time
to time, the rules under Section 16 of the  Securities  Exchange Act of 1934, as
amended form time to time, rules of any stock exchange or over-the-counter stock
market,  on which the Company's Common Stock is traded or as otherwise  required
by law. The 1999 Plan will  terminate ten years from the date of adoption by the
Board of Directors. No option may be granted under the 1999 Plan thereafter, but
such  termination  will not affect the validity of options  granted prior to the
date of termination.

      Federal Tax Consequences.  The following general discussion of the Federal
income tax  consequences  of the issuance and exercise of options  granted under
the 1999 Plan is based upon the  provisions  of the Internal  Revenue Code as in
effect on the date of this proxy  statement  (the "Code"),  current  regulations
thereunder, and existing administrative rulings of the Internal Revenue Service.
It is not intended to be a complete  discussion of all of the Federal income tax
consequences of the 1999 Plan or the  requirements  that must be met in order to
qualify for the described tax treatment.  Changes in the law and regulations may
modify the  discussion,  and in some cases the  changes may be  retroactive.  No
information is provided as to the state tax laws. The 1999 Plan is not qualified
under  Section  401 of the  Code and is not  subject  to the  provisions  of the
Employee Retirement Income Security Act of 1974, as amended.

      Non-Qualified  Stock  Options  under the 1999  Plan.  The  recipient  of a
non-qualified  stock option under the 1999 Plan will not  recognize  any taxable
income at the time the option is  granted.  Generally,  the option  holder  will
recognize  ordinary  taxable  income at the time the option is  exercised  in an
amount  equal to the  excess of the fair  market  value of the  shares of Common
Stock on the date of exercise  over the exercise  price.  Certain  employees and
Directors

                                       21

<PAGE>

eligible to  participate in the 1999 Plan may be subject to Section 16(b) of the
Securities Exchange Act of 1934, as amended ("Section 16(b)") upon their sale of
shares of Common Stock and this may affect their tax  liability.  In the case of
exercise  of an option by  someone  whose sale of shares of Common  Stock  would
subject him or her to liability  under Section  16(b),  recognition of income by
the option holder will be postponed.  The Internal  Revenue Service  regulations
have not yet been  amended to conform  with the  recently  revised  rules  under
Section 16(b). However, it is generally anticipated that the date of recognition
(the  "Recognition  Date") will be the earlier of (i) six months  after the date
the  option was  granted,  or (ii) the first day on which the sale of the shares
would not subject  the  individual  to  liability  under  Section  16(b).  It is
possible  that the six month  period will  instead run from the option  holder's
most recent  grant or purchase of Common  Stock prior to his or her  exercise of
the option.  The option holder will generally  recognize ordinary taxable income
on the  Recognition  Date in an amount  equal to the  excess of the fair  market
value of the shares at that time over the exercise  price.  Despite this general
rule,  if the  Recognition  Date is after the date of exercise,  then the option
holder may make an election pursuant to Section 83(b) of the Code, in which case
the option holder will recognize  ordinary taxable income at the time the option
is exercised  and not on the later  Recognition  Date. In order to be effective,
the 83(b)  election  must be filed with the  Company  and the  Internal  Revenue
Service within 30 days of exercise.

      The Company will  generally be entitled to a  compensation  deduction  for
Federal income tax purposes in an amount equal to the taxable income  recognized
by the option  holder,  provided  the Company  reports the income on a form 1099
that is timely provided to the option holder and filed with the Internal Revenue
Service.

      When an option holder subsequently  disposes of the shares of Common Stock
received  upon  exercise of an option,  he or she will  recognize  long-term  or
short-term  capital  gain or loss  (depending  upon the holding  period),  in an
amount equal to the difference between the sale price on the date of disposition
and the fair  market  value on the date on which the  option  holder  recognized
ordinary taxable income as a result of the exercise of the option.

      An option  holder who pays the  exercise  price,  in whole or in part,  by
delivering  shares of Common Stock already owned by him or her will recognize no
gain or loss for  Federal  income tax  purposes on the shares  surrendered,  but
otherwise will be taxed according to the rules describe above. To the extent the
shares acquired upon exercise are equal in number to the shares surrendered, the
basis and holding  period of the shares  received will be equal to the basis and
holding period of the shares surrendered. The basis of shares received in excess
of the shares  surrendered  upon exercise will be equal to the fair market value
of the shares on the date of  exercise,  and the  holding  period for the shares
received will commence on that date.

Vote Required to Adopt the 1999 Plan

      The affirmative  vote of a majority of holders of the Common Stock present
in person or by proxy at the Meeting is required for adoption of Proposal No. 3.

         The Board of Directors  recommends that  stockholders vote FOR approval
of Proposal No.3.

                                       22
<PAGE>


                                 PROPOSAL NO. 4
                         PROPOSAL TO ADOPT THE COMPANY'S
                          EMPLOYEE STOCK PURCHASE PLAN

      The Board of Directors has adopted,  subject to stockholder approval,  the
Boston  Biomedica,  Inc. 1999 Employee Stock Purchase Plan (the "Stock  Purchase
Plan").

Summary of the Stock Purchase Plan

      The following is a summary  description  of the Stock Purchase Plan and is
qualified in its entirety by  reference to the text of the Stock  Purchase  Plan
which is set forth as Exhibit C to this proxy statement.

      Purpose.  The Stock Purchase Plan is intended to provide  employees of the
Company with  additional  incentives by permitting them to acquire a proprietary
interest in the Company  through the purchase of shares of the Company's  Common
Stock.

      Administration.  The  Stock  Purchase  Plan  will be  administered  by the
Company's Compensation Committee, or such other committee consisting of not less
than two members of the Company's  Board of Directors  appointed by the Board of
Directors, who are not also employees of the Company.

      Eligible Participants. The Stock Purchase Plan provides that all employees
of the Company  (including  Officers and  Directors) who work more than 20 hours
per week and more than five months in any calendar  year and who have  completed
twelve  consecutive  months,  or  two  years,  whether  or not  consecutive,  of
employment  on or before  the first day of the  applicable  offering  period are
eligible to  participate.  However,  no employee  who holds five percent (5%) or
more of the Company's Common Stock will be eligible to participate.  Further, no
employee  may be granted an option  pursuant  to which the  employee's  right to
purchase  Common  Stock under the Stock  Purchase  Plan  accrues at a rate which
exceeds $25,000 of fair market value of such stock per year.  Approximately  200
employees would currently be eligible to participate in the Stock Purchase Plan.

      Offering  Periods and Stock  Options.  Eligible  employees  of the Company
elect to  participate in the Stock Purchase Plan by giving notice to the Company
and  instructing  the  Company to withhold a  specified  dollar  amount from the
employee's  salary during the following  six-month  period (the periods run from
January 1st to June 30th and July 1st to  December  31st and each is referred to
as an "Offering  Period").  The first  Offering  Period will commence on July 1,
1999. On the last business day of that Offering  Period,  the amount withheld is
used to purchase  Common Stock at a price equal to the lesser of 85% of the fair
market value of the Common Stock on either the first day of the Offering  Period
or on the last day of the  Offering  Period,  whichever  is less (the  "Exercise
Price"). (For this purpose, fair market value is the average of the high and low
sales prices as reported on the Nasdaq National Market System.) If no shares are
traded on those days,  the average of the fair market values on the  immediately
preceding and the next following business day on which shares are traded is used
instead. The Company grants an

                                       23
<PAGE>

option  to  each  participant,  on the  first  day of the  Offering  Period,  to
purchase,  on the last day of the Offering Period,  at the Exercise Price,  that
number of shares of Common Stock that his or her accumulated  payroll deductions
on the last day of the Offering Period will pay for at such price. The option is
automatically  deemed to be exercised if the employee is still a participant  on
the  last  day of the  Offering  Period.  Participation  ends  automatically  on
termination of employment with the Company.

      Authorization  for Entering the Plan and Allowable Payroll  Deductions.  A
participating  employee  may  authorize a payroll  deduction of any whole dollar
amount,  equal to but not to exceed  more than ten  percent  (10%) of his or her
base pay (including  commissions,  if applicable),  but not less than $10.00 per
payroll period. Deductions from any employee's compensation may not be increased
or decreased  during an Offering  Period.  Under the Stock  Purchase  Plan,  the
number of shares  purchased  at the end of the  Offering  Period may not be more
than 1,250 shares on any such date.

      Withdrawal from the Plan. An employee may withdraw from the Stock Purchase
Plan, and withdraw all of the payroll deductions  credited to his or her account
under the Stock Purchase Plan, at any time prior to the last business day of any
Offering  Period.  Upon such a  withdrawal,  the  Company  will  refund  without
interest the entire remaining balance of the employee's deductions.

      Shares  Subject to Stock  Purchase  Plan.  The maximum number of shares of
Common Stock which may be purchased by employees  under the Stock  Purchase Plan
is 250,000 shares,  subject to adjustments for stock splits, stock dividends and
similar  transactions.  Such shares may be  authorized  but  unissued  shares of
Common Stock or shares of Common  Stock  reacquired  by the  Company,  including
shares purchased in the open market.

      Amendment  of the Stock  Purchase  Plan.  The Stock  Purchase  Plan may be
amended by the Board of Directors  from time to time in any  respect;  provided,
however,  that no amendment shall be effective without  stockholder  approval if
the  amendment  would  materially  increase the number of shares of Common Stock
which  may be  issued  under the  Stock  Purchase  Plan or  change  the class of
employee eligible to participate in the Stock Purchase Plan.

      Federal Tax  Consequences.  The Stock Purchase Plan is intended to qualify
as an "employee  stock purchase plan" under Section 423 of the Internal  Revenue
Code of 1986, as amended (the "Code").  An employee will not recognize income on
the grant or  exercise  of an option  under the  Stock  Purchase  Plan,  and the
Company  will not  have a  corresponding  deduction.  If the  employee  does not
dispose of the  shares of Common  Stock for at least two years from the grant of
an option under the Stock  Purchase  Plan,  the employee  will realize  ordinary
income upon disposition (including by sale, gift or death) in an amount equal to
the lesser of: (i) the excess of the fair  market  value of the Common  Stock at
the time of disposition  over the Option Exercise Price, or (ii) 15% of the fair
market value of the Common Stock on the first day of the Offering  Period.  Gain
in excess of this amount,  if any,  will be taxed as long-term  capital gain. If
the sale price is less than the price paid,  the employee will not recognize any
ordinary  income,  and any loss  that he or she  suffers  on the sale  will be a
capital loss. The

                                       24
<PAGE>

Company  will not have a  deductible  compensation  expense  as a result  of the
purchase of stock under the Stock  Purchase  Plan,  unless  there is a premature
disposition, as described in the next paragraph.

      If shares  purchased under the Stock Purchase Plan are sold by an employee
within two years after the option is granted,  then the  employee  will  realize
ordinary  income in the year of  disposition in an amount equal to the excess of
the fair  market  value of the  shares on the date of  exercise  over the Option
Exercise Price. Any remaining gain will be treated as capital gain, which may be
long or short  term,  depending  on the time that the  shares  are  held.  If an
employee does recognize ordinary income as a result of a premature  disposition,
a compensation deduction is allowed to the Company in an equal amount,  provided
the Company  timely  provides the recipient and the IRS with a form W-2 or W-2c,
whichever is applicable.

      The foregoing  summary of the effect of Federal  income  taxation upon the
participant  and the Company  with  respect to the  purchase of shares under the
Stock  Purchase Plan does not purport to be complete,  and  reference  should be
made to the  applicable  provisions of the Code. In addition,  this summary does
not discuss the provisions of the income tax laws of any municipality, state, or
foreign country in which the participant may reside.

Vote Required to Adopt the Stock Purchase Plan

      The  affirmative  vote of a majority of the votes of holders of the Common
Stock  present in person or by proxy at the Meeting is required  for adoption of
Proposal No. 4.

      The Board of Directors  recommends that  stockholders vote FOR approval of
Proposal No. 4.

                                       25

<PAGE>


                                  OTHER MATTERS

Voting Procedures

      The votes of stockholders present in person or represented by proxy at the
Meeting will be tabulated by an inspector of elections appointed by the Company.
A quorum,  consisting of a majority of shares of all stock  issued,  outstanding
and entitled to vote at the Meeting, will be required to be present in person or
by proxy for consideration of the proposal to elect Directors,  for the proposal
to amend the  Employee  Stock  Option  Plan,  for the proposal to adopt the 1999
Plan,  and for the proposal to adopt the Stock  Purchase  Plan. The nominees for
Director  of the  Company  who  receive  the  greatest  number of votes  cast by
stockholders  present  in  person or  represented  by proxy at the  Meeting  and
entitled  to  vote  thereon  will  be  elected  Director  of  the  Company.  The
affirmative vote of the holders of a majority of shares of Common Stock, present
in person or represented by Proxy,  at the Meeting and entitled to vote thereon,
is required to approve the amendment of the Employee Stock Option Plan, to adopt
the 1999 Plan, and to adopt the Stock Purchase Plan.

      Abstentions  will  have no  effect  on the  outcome  of the  vote  for the
election of the  Directors,  but will have the effect of being cast  against the
proposal to amend the Employee Stock Option Plan,  against the proposal to adopt
the 1999 Plan,  and against the proposal to adopt the Stock  Purchase  Plan even
though the stockholder so abstaining intends a different interpretation.  Shares
of Common  Stock held of record by brokers  who do not return a signed and dated
Proxy will not be considered present at the Meeting, will not be counted towards
a quorum, and will not be voted in the election of Directors, on the proposal to
amend the Employee Stock Option Plan, on the proposal to adopt the 1999 Plan, or
on the proposal to adopt the Stock Purchase Plan. Shares of Common Stock held of
record by brokers  who  return a dated and signed  Proxy but who fail to vote on
one of the  proposals  will count toward the quorum,  but will count neither for
nor against the Proposal not voted.

Independent Accountants

      The   Board   of    Directors    will    review   the    appointment    of
PricewaterhouseCoopers LLP as the independent accountants to audit the Company's
consolidated  financial statements for the fiscal year ending December 31, 1999.
Such firm has served continuously in that capacity since 1993.

      A representative of PricewaterhouseCoopers  LLP will be at the Meeting and
will  be  given  an  opportunity  to  make  a  statement,  if  so  desired.  The
representative will be available to respond to appropriate questions.


Section 16(a) Beneficial Ownership Reporting Compliance

      Section 16(a) of the Securities Exchange Act of 1934, as amended, requires
the Company's  Executive  Officers and Directors,  and persons who own more than
10% of the Company's  Common Stock,  to file reports of ownership and changes in
ownership on Forms 3, 4 and 5 with 

                                       26
<PAGE>


the  Securities  and Exchange  Commission  and the Nasdaq.  Executive  Officers,
Directors and greater than 10%  stockholders are required to furnish the Company
with copies of all Forms 3, 4 and 5 they file.

      Based solely on the Company's  review of the copies of such Form(s) it has
received and written  representations  from certain  reporting persons that they
were not  required  to file  Form 5 for  specified  fiscal  years,  the  Company
believes  that all of its  Executive  Officers,  Directors  and greater than 10%
stockholders  complied with all Section 16(a) filing requirements  applicable to
them during the Company's fiscal year ended December 31, 1998.


                                       27


<PAGE>


Other Proposed Action

      The Board of  Directors  knows of no  matters  which may come  before  the
Meeting other than the election of  Directors,  the proposal to amend the Boston
Biomedica,  Inc.  Employee  Stock Option Plan,  the proposal to adopt the Boston
Biomedica,  Inc. 1999  Nonqualified  Stock Option Plan and the proposal to adopt
the Boston Biomedica,  Inc. 1999 Employee Stock Purchase Plan.  However,  if any
other matters should properly be presented to the Meeting,  the persons named as
proxies shall have discretionary authority to vote the shares represented by the
accompanying proxy in accordance with their own judgment.

Stockholder Proposals

      Proposals  which  stockholders  intend to  present at the  Company's  2000
Annual Meeting of Stockholders  and wish to have included in the Company's proxy
materials  pursuant to Rule 14A-8  promulgated under the Securities Act of 1934,
as amended,  must be  received by the Company no later than March 8, 2000.  If a
proponent  fails to notify  the  Company by April 24,  2000 of a non-Rule  14A-8
stockholder  proposal  which it intends to submit at the  Company's  2000 Annual
Meeting of  Stockholders,  the Proxy  solicited by the Board of Directors,  with
respect to such Meeting, may grant discretionary  authority to the Proxies named
therein, to vote with respect to such matter.

Incorporation By Reference

      To the extent that this Proxy  Statement has been or will be  specifically
incorporated  by reference  into any filing by the Company under the  Securities
Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, the
sections of the Proxy Statement  entitled  "Compensation  Committee  Report" and
"Performance  Graph"  shall  not  be  deemed  to  be  so  incorporated,   unless
specifically otherwise provided in any such filing.

Annual Report on Form 10-K

      Copies of the  Company's  Annual  Report on Form 10-K for the fiscal  year
ended December 31, 1998 as filed with the Securities and Exchange Commission are
available  to  stockholders  without  charge upon written  request  addressed to
Investor Relations,  Boston Biomedica,  Inc., 375 West Street, West Bridgewater,
Massachusetts 02379.

      IT IS IMPORTANT THAT PROXIES BE RETURNED PROMPTLY. THEREFORE, STOCKHOLDERS
ARE URGED TO FILL IN,  SIGN AND  RETURN  THE  ACCOMPANYING  FORM OF PROXY IN THE
ENCLOSED ENVELOPE.

                                       28

<PAGE>


                                    EXHIBIT A

                             BOSTON BIOMEDICA, INC.
                           EMPLOYEE STOCK OPTION PLAN

      1. Purpose.  The purpose of this Boston  Biomedica,  Inc.  Employee  Stock
Option Plan (the  "Plan") is to provide  increased  incentives  to  employees of
Boston  Biomedica,  Inc. and its Parent and  Subsidiaries,  if any (referred to,
unless  the  context  otherwise  requires,   as  the  "Corporation")  to  remain
affiliated  with the  Corporation,  to promote the success of the  Corporation's
business,  to encourage new employees to become  affiliated with the Corporation
and to associate  more  closely the  interests of such persons with those of the
Corporation  through the granting of options to acquire the capital stock of the
Corporation.

      2.  Definitions.  As used  herein,  the  following  terms  will  have  the
indicated meaning:

      "Board" means the "Board of Directors" of the Corporation.

      "Code" means the Internal  Revenue Code of 1986, as it may be amended from
time to time.

      "Committee" means the Committee of the Board as described in Section 4.

      "Corporation" means Boston Biomedica, Inc.

      "Fair Market Value" means,  on the date for which the Fair Market Value is
to be determined,  the closing price of the Corporation's  Stock on the New York
Stock  Exchange,  American  Stock  Exchange  or such other  national  securities
exchange or the National  Association of Securities Dealers Automated  Quotation
System on which the Stock is then traded, or if no such price is available or if
the Stock is not then so traded, the fair market value reasonably  determined by
the Committee in good faith.

      "Incentive  Stock  Option"  means any  Option  issued  hereunder  which is
treated as an Incentive Stock Option under Section 422 of the Code.

      "Option"  means the  contractual  right to  purchase  shares of Stock upon
specified terms pursuant to this Plan.

      "Parent" has the meaning  specified  for "Parent  Corporation"  in Section
424(e) of the Code.

      "Permanent and Total  Disability" has the meaning  specified for permanent
and total disability in Section 22(e)(3) of the Code.

      "Plan" means this Boston Biomedica, Inc. Employee Stock Option Plan.

                                       29

<PAGE>

      "Employees"  means all those  persons who are employed by the  Corporation
for a minimum of 20 hours per week.

      "Stock" means the Common Stock, $.01 par value, of the Corporation.

      "Subsidiary"  has the meaning  specified for  "Subsidiary  Corporation" in
Section 424(f) of the Code.

      "Ten Percent  Stockholder"  means an individual who directly or indirectly
owns capital stock  possessing  more than 10% of the total combined voting power
of all classes of capital stock of the  Corporation  or any Parent or Subsidiary
at the time an Incentive Stock Option is granted under this Plan.

      3.  Stock  Subject  to the  Plan.  The  aggregate  number of shares of the
Corporation's  Stock  that may be  issued  and  sold  under  the  Plan  shall be
1,500,000  shares.  The shares of Stock to be issued  upon  exercise  of Options
granted under this Plan shall be made available,  at the discretion of the Board
of Directors,  from (i) authorized but unissued shares,  (ii) shares  previously
reserved  for  issuance  upon  exercise  of Options  which have  expired or been
terminated,  or (iii) treasury  shares and shares  reacquired by the Corporation
for this purpose,  including shares purchased in the open market.  If any Option
granted under this Plan shall expire or terminate for any reason  without having
been exercised in full,  the  unpurchased  shares  covered  thereby shall become
available for grant under additional  Options under the Plan so long as it shall
remain in effect.

      4. Administration of the Plan.

      (a) The Plan shall be administered  by the Committee.  The Committee shall
consist of at least one member  appointed  by the Board,  and such member  shall
serve at the  pleasure  of the  Board.  The Board may from time to time  appoint
additional members of the Committee or remove members and appoint new members in
substitution for those previously appointed and fill vacancies however caused. A
majority of the Committee  shall  constitute a quorum and the acts of a majority
of the  members  present at any  meeting  at which a quorum is present  shall be
deemed the action of the Committee. At such time as any class of equity security
of the  Corporation  is  registered  pursuant  to Section  12 of the  Securities
Exchange Act of 1934, as amended (the "Act"), (i) the Committee shall consist of
at least two  members of the Board and (ii) no member of the  Committee  while a
member  thereof shall be eligible to participate in the Plan, nor may any person
be appointed to the Committee  unless he or she was not eligible to  participate
in the Plan or any other plan of the Corporation at any time within the one-year
period  immediately  prior  to  such  appointment  as  provided  in  Rule  16b-3
promulgated under the Act.

      (b) Subject to the express  provisions  of this Plan and provided that all
actions taken shall be consistent  with the purposes of the Plan,  the Committee
shall have full and complete authority and the sole discretion to: (i) determine
those  Employees of the  Corporation  to whom Options shall be granted under the
Plan;  (ii)  determine  the number of shares of Stock subject to and the form of
Options to be granted to such Employees; (iii) amend the number of shares


                                       30

<PAGE>

covered by and the form of the Options to be granted; (iv) determine the time or
times when Options shall be granted; (v) establish the terms and conditions upon
which Options may be exercised and/or transferred;  (vi) establish the terms and
conditions,  if any,  upon which the shares of Stock  issuable  upon exercise of
Options  may be  transferred,  including,  but not limited to the return of such
shares to the Corporation upon the occurrence of certain events; (vii) alter any
restrictions or conditions upon Options and/or the shares of Stock issuable upon
exercise of Options; and (viii) adopt rules and regulations,  establish,  define
and/or   interpret  any  other  terms  and   conditions,   and  make  all  other
determinations  (which  may be on a  case-by-case  basis)  deemed  necessary  or
desirable for the administration of the Plan.

      (c) In making its determinations  hereunder, the Committee shall take into
account the nature of the services  rendered or to be rendered by the Employees,
their present and potential contributions to the success of the Corporation, and
such other factors as the Committee,  in its discretion,  shall deem relevant in
order to accomplish the purposes of the Plan.

      5.  Eligibility.  Options may be granted only to persons who are Employees
as defined in Section 2 of ----------- this Plan.

      6. Terms of Options and Limitations Thereon.

      (a) General.  Any Option  granted  under this Plan shall be evidenced by a
written  agreement  between the  Corporation  and the Option holder and shall be
upon such terms and conditions not inconsistent  with this Plan as the Committee
may determine.  The Committee shall designate, at the time of the grant, whether
the Option is an Incentive Stock Option.  If the Option is not intended to be an
Incentive  Stock Option,  but otherwise  qualifies as an Incentive  Stock Option
under the  Code,  such  agreement  shall  include  the  following,  or a similar
statement:  "This Stock Option is not intended to be an Incentive  Stock Option,
as that term is described  in Section 422 of the Internal  Revenue Code of 1986,
as amended."

      (b)  Price.  The  price at which  any  shares  of Stock  may be  purchased
pursuant  to the  exercise  of an Option  shall be for any lawful  consideration
determined by the  Committee,  but not less than par value,  and, in the case of
any Incentive Stock Option,  such purchase price shall not be less than the Fair
Market  Value of the Stock on the date of the grant of the  Option  (or,  in the
case of Ten Percent  Stockholders,  110% of the Fair Market Value on such date),
without regard to any restrictions  other than those restrictions which by their
terms will never lapse.

      (c) Period of Option.  Each Option  granted under this Plan shall continue
in effect for such period as the  Committee  shall  determine,  provided that no
Incentive Stock Option, or installment thereof, may be exercisable subsequent to
ten years from the date of grant  (five years from the date of grant in the case
of Incentive  Stock Options  issued to Ten Percent  Stockholders).  No Incentive
Stock Option shall be exercisable  beyond three months after the date upon which
the Incentive  Stock Option holder ceases to be an employee of the  Corporation,
except that the Committee may provide in the Incentive  Stock Option that in the
event of  termination  of  employment  by reason of death or Permanent and Total
Disability  of the holder,  the  Incentive  Stock Option may be exercised by the
holder or his or her estate for a period of up

                                       31
<PAGE>

to one year after  termination of employment.  The Committee may provide for the
termination of any Option upon  termination of the Option  holder's  affiliation
with the Corporation.

      (d)  Non-Assignability.  No Option or right or interest in an Option shall
be  assignable  or  transferable  by the  holder  except  by will or the laws of
descent and distribution.  During the lifetime of the holder, an Option shall be
exercisable only by him or her.

      (e) Other  Restrictions.  At the discretion of the Committee,  any Options
granted and the shares of Stock issuable upon exercise of Options may be subject
to restrictions on vesting or  transferability or to risk of forfeiture upon the
happening of such events as the  Committee  may  determine,  any of which may be
accelerated or waived in the Committee's sole discretion.

      7.  One  Hundred  Thousand  Dollar  Limitation.  To the  extent  that  the
aggregate  Fair Market Value of Stock with respect to which any incentive  stock
options  of the  Corporation  issued  under  this Plan or any other  plan of the
Corporation  (determined without regard to this Section) are exercisable for the
first time by any  holder  during  any  calendar  year  exceeds  $100,000,  such
Incentive  Stock  Options  shall be treated as Options  which are not  Incentive
Stock Options.  For the purpose of this limitation,  Options shall be taken into
account in the order  granted,  and the Committee may designate  that portion of
any  Incentive  Stock  Option  that shall be treated as not an  Incentive  Stock
Option in the event that the  provisions  of this Section  apply to a portion of
any Option, unless otherwise required by the Code or regulations of the Internal
Revenue Service. The designation described in the preceding sentence may be made
at  such  time as the  Committee  considers  appropriate,  including  after  the
issuance of the Option or at the time of its  exercise.  For the purpose of this
Section,  Fair Market Value shall be  determined  as of the time the Option with
respect to which such Stock is granted.

      8. Exercise of Options; Payment.

      (a) Options may be  exercised in whole or in part at such time and in such
manner as the  Committee may determine and as shall be prescribed in the written
agreement with each holder.

      (b) The purchase price of shares of Stock upon exercise of an Option shall
be paid by the Option  holder in full upon exercise and may be paid (i) in cash,
(ii) by delivery of shares of Stock  (valued at Fair Market Value at the date of
purchase of the shares of Stock subject to the Option), or (iii) any combination
of cash and Stock, as the Committee may permit. The Committee also may allow the
cashless exercise of Options, subject to applicable law.

      9. Stock Adjustments.

      (a) If the  Corporation  is a party to any  merger or  consolidation,  any
purchase or acquisition of property or stock, or any separation,  reorganization
or  liquidation,  the  Board  of  Directors  (or if the  Corporation  is not the
surviving  corporation,  the board of  Directors of the  surviving  corporation)
shall have the power to make arrangements, which shall be binding upon

                                       32
<PAGE>

the holders of unexpired  Options,  for the  substitution of new Options for, or
the assumption by another corporation of, any unexpired Options then outstanding
hereunder.

      (b) If by reason of  recapitalization,  reclassification,  stock split-up,
combination  of shares,  separation  (including  a spin-off)  or dividend on the
Stock payable in Stock,  the outstanding  shares of Stock of the Corporation are
increased or decreased  or changed into or exchanged  for a different  number or
kind of shares or other  securities of the  Corporation,  the Board of Directors
shall conclusively  determine the appropriate  adjustment in the exercise prices
of  outstanding  Options  and in the  number  and  kind of  shares  as to  which
outstanding Options shall be exercisable.

      (c) In the event of a transaction  of the type described in paragraphs (a)
and (b)  above,  the total  number of  shares of Stock on which  Options  may be
granted  under  this  Plan  shall  be  appropriately  adjusted  by the  Board of
Directors.

      10. No Rights  Other Than Those  Expressly  Created.  No  Employee  of the
Corporation  or other  person  shall  have any claim or right to be  granted  an
Option  hereunder.  Neither  this Plan nor any action taken  hereunder  shall be
construed as (i) giving any Option holder any right to be retained in the employ
of the  Corporation,  (ii) giving any Option holder an equity or interest of any
kind in any assets of the Corporation,  or (iii) creating a trust of any kind or
a  fiduciary  relationship  of any kind  between  the  Corporation  and any such
person.  As to any claim for any unpaid  amounts  under  this  Plan,  any person
having a claim for payments  shall be an unsecured  creditor.  No Option  holder
shall have any of the rights of a  stockholder  with  respect to shares of Stock
covered by an Option until such time as the Option has been exercised and shares
of Stock have been issued to such person.

      11. Miscellaneous.

      (a) Withholding of Taxes. Pursuant to applicable Federal,  state, local or
foreign laws, the  Corporation  may be required to collect income or other taxes
upon the  grant of an Option  to, or  exercise  of an Option  by, a holder.  The
Corporation may require,  as a condition to the exercise of an Option,  that the
recipient pay the Corporation,  at such time as the Committee or the Corporation
determines,  the amount of any taxes which the Committee or the  Corporation may
determine  is  required  to be withheld or  collected.  In its  discretion,  the
Corporation  may  withhold  shares of Stock to be received  upon  exercise of an
Option if it deems this an  appropriate  method for  withholding  or  collecting
taxes.

      (b) Legal and Other  Requirements.  Upon exercise of an Option, the holder
shall be required to make such  representations  and furnish such information as
may, in the opinion of counsel for the Corporation, be appropriate to permit the
Corporation  to issue or  transfer  the shares of Stock in  compliance  with the
provisions of applicable  Federal or state securities laws. The Corporation,  in
its  discretion,  may postpone the issuance and delivery of shares of Stock upon
any  exercise  of an  Option  until  completion  of such  registration  or other
qualification  of such shares under any Federal or state laws, or stock exchange
listing, as the Corporation may consider appropriate.  The Committee may require
that prior to the issuance or transfer of Stock

                                       33
<PAGE>

upon  exercise of an Option,  the  recipient  enter into a written  agreement to
comply with any restrictions on subsequent disposition that the Committee or the
Corporation deems necessary or advisable under any applicable law, regulation or
official  interpretation  thereof.  No  shares  of Stock  shall be  issued  upon
exercise of Options unless and until the  Corporation is satisfied,  in its sole
discretion,   that  there  has  been  compliance  with  all  legal  requirements
applicable  to the  issuance  of  such  shares.  Certificates  of  Stock  issued
hereunder may be legended to reflect such restrictions.

      (c) Indemnity.  Neither the Board of Directors nor the Committee,  nor any
members of either, nor any employees of the Corporation, shall be liable for any
act, omission, interpretation,  construction or determination made in good faith
in  connection  with their  responsibilities  with respect to the Plan,  and the
Corporation  hereby  agrees to indemnify  the members of the Board of Directors,
the members of the Committee, and the employees of the Corporation in respect of
any claim,  loss,  damage, or expense  (including counsel fees) arising from any
such act,  omission,  interpretation,  construction or determination to the full
extent permitted by law.

      12. Effective Date; Amendment; Termination.

      (a) The  effective  date of this Plan shall be the date of adoption by the
Board of Directors;  provided, however, that the Plan is subject to the approval
of the  stockholders  at the next meeting of stockholders of the Corporation and
within twelve months from the effective date of this Plan.

      (b) The date of grant of any Option  granted  hereunder  shall be the date
upon  which  such  Option  shall  be  voted by the  Committee,  unless  the vote
expressly otherwise provides.

      (c) The Board of Directors of the  Corporation  may at any time,  and from
time to  time,  amend,  suspend  or  terminate  this  Plan in  whole or in part;
provided,  however,  that the Board of Directors may not materially increase the
benefits accruing to participants in the Plan, materially increase the number of
shares of Stock  reserved  for  purposes of this Plan other than  pursuant to an
adjustment  under  Section  9,  or  materially  modify  the  requirements  as to
eligibility for participation in this Plan without stockholder approval.

      (d) Without amending this Plan,  except to the extent required by the Code
in the case of Incentive Stock Options,  the Committee may modify grants made to
participants who are foreign nationals or otherwise  employed outside the United
States so as to recognize differences in local law, tax policy or custom.

      (e) Except as provided herein, no amendment,  suspension or termination of
this Plan may affect the rights of any person to whom an Option has been granted
without such person's consent.

      (f)  Stockholder   approval  of  this  Plan  or  any  amendment  requiring
stockholder  approval under paragraph (c) shall mean the affirmative  vote of at
least a majority of the shares of capital  stock present and entitled to vote at
a duly held meeting of stockholders unless a

                                       34
<PAGE>

greater  vote is required by state or Federal law.  Stockholder  approval may be
obtained by written consent or other means permitted by applicable state law.

      (g) This Plan shall  terminate ten (10) years from the earlier of the date
of stockholder  approval of the Plan or its effective  date, and no Option shall
be granted under this Plan thereafter, but such termination shall not affect the
validity of Options granted prior to the date of termination.

      (h) This Plan and all Options  granted  hereunder shall be governed by the
law of the state in which the Corporation is incorporated.

Date of Board of Director Adoption:  March 29, 1994

Date of Stockholder Approval:  June 29, 1994

                                                  A true copy.

                                                  ATTEST:


                                                  ------------------------------
                                                  Clerk



                                       35
<PAGE>


                                    EXHIBIT B

                              BOSTON BIOMEDICA INC.
                       1999 NONQUALIFIED STOCK OPTION PLAN

1.  Name and Purpose
    ----------------
      This plan shall be known as the Boston Biomedica,  Inc. 1999 Non-Qualified
Stock Option Plan (the "Plan"). The purpose of the Plan is to attract and retain
employees, Directors, advisers and consultants and provide an incentive for them
to  assist  Boston  Biomedica,   Inc.  (the  "Company")  to  achieve  long-range
performance  goals, and to enable them to participate in the long-term growth of
the Company. 

2. Definitions 
   -----------

(a)   "Award" means any Option awarded under the Plan.

(b)   "Board" means the Board of Directors of the Company.

(c)   "Code"  means the Internal  Revenue Code of 1986,  as amended from time to
      time.

(d)   "Committee"  means the full  Board,  or such  other  Committee  consisting
      solely of two or more non-employee Directors.

(e)   "Common  Stock" or  "Stock"  means the  Common  Stock,  par value $.01 per
      share, of the Company.

(f)   "Company"  means Boston  Biomedica,  Inc. and any business entity in which
      Boston  Biomedica,  Inc. owns  directly or  indirectly  50% or more of the
      total combined voting power.

(g)   "Designated   Beneficiary"   means  the   beneficiary   designated   by  a
      Participant,  in a manner  determined by the Board, to receive amounts due
      or exercise  rights of the  Participant in the event of the  Participant's
      death.  In the  absence  of an  effective  designation  by a  Participant,
      Designated Beneficiary shall mean the Participant's estate.

(h)   "Fair  Market  Value"  means,  with  respect to Common  Stock or any other
      property,  the fair market  value of such  property as  determined  by the
      Board in good faith or in the manner established by the Board from time to
      time.

(i)   "Nonqualified  Stock Option" means an option to purchase  shares of Common
      Stock,  awarded to a Participant under Section 6, which is not intended to
      comply as an incentive  stock option under  Section 422 of the Code or any
      successor provision.

(j)   "Option" means a Nonqualified Stock Option.

(k)   "Option Price" means the exercise price of an Option.

(l)   "Participant"  means a person  eligible  pursuant  to Section 4 hereof and
      selected by the Board to receive an Award under the Plan.

                                       36
<PAGE>

3.  Administration
    --------------

      The Plan shall be administered by the Committee.  The Committee shall have
authority to adopt, alter and repeal such administrative  rules,  guidelines and
practices  governing  the  operation  of the Plan as it shall  from time to time
consider advisable,  and to interpret the provisions of the Plan. The Committe's
decisions shall be final and binding. To the extent permitted by applicable law,
the Board may delegate to the Committee the power to make Awards to Participants
and all determinations under the Plan with respect thereto.


4.  Eligibility
    -----------

      All employees, Directors, advisers and consultants of the Company, capable
of contributing  significantly to the successful  performance of the Company are
eligible to be Participants in the Plan.


5.  Stock Available for Awards
    --------------------------

(a)   Subject to adjustment  under  subsection (b), Awards may be made under the
      Plan of  Options  to  acquire  not in excess of  500,000  shares of Common
      Stock.  If any Award in  respect of shares of Common  Stock  expires or is
      terminated  unexercised  or is  forfeited  for any  reason or settled in a
      manner  that  results  in fewer  shares  outstanding  than were  initially
      awarded,  including without  limitation the surrender of shares in payment
      for the Award or any tax  obligation  thereon,  the shares subject to such
      Award  or so  surrendered,  as the  case  may be,  to the  extent  of such
      expiration,  termination, forfeiture or decrease, shall again be available
      for award under the Plan.  Common Stock issued  through the  assumption or
      substitution  of  outstanding  grants from an acquired  Company  shall not
      reduce the shares  available  for Awards under the Plan.  Shares of Common
      Stock issued under the Plan may consist in whole or in part of  authorized
      but unissued shares or treasury shares.

(b)   In the  event  that the  Committee  determines  that any  stock  dividend,
      extraordinary  cash  dividend,  creation of a class of equity  securities,
      recapitalization,   reorganization,   merger,   consolidation,   split-up,
      spin-off, combination,  exchange of shares, warrants or rights offering to
      purchase Common Stock at a price substantially below fair market value, or
      other similar transaction affects the Common Stock such that an adjustment
      is required  in order to  preserve  the  benefits  or  potential  benefits
      intended to be made available  under the Plan,  then the Committee,  shall
      equitably  adjust  any or all of (i) the  number  and  kind of  shares  in
      respect of which  Awards  may be made under the Plan,  (ii) the number and
      kind of shares subject to outstanding  Awards, and (iii) the Option Price,
      Award,  or conversion  price with respect to any of the foregoing,  and if
      considered  appropriate,  the  Committee  may  make  provision  for a cash
      payment with respect to an outstanding Award,  provided that the number of
      shares subject to any Award shall always be a whole number.

                                       37
<PAGE>


6.  Stock Options
    -------------

(a)   Subject  to  the   provisions  of  the  Plan,   the  Committee  may  award
      Nonqualified  Stock  Options  and  determine  the  number  of shares to be
      covered by each Option,  the Option Price  therefor and the conditions and
      limitations applicable to the exercise of the Option.

(b)   The Committee  shall establish the Option Price at the time each Option is
      awarded.

(c)   Each Option shall be  exercisable  at such times and subject to such terms
      and  conditions as the Committee  may specify in the  applicable  Award or
      thereafter.  The Committee may impose such  conditions with respect to the
      exercise of Options,  including  conditions relating to applicable Federal
      or state securities laws, as it considers necessary or advisable.

(d)   No shares shall be  delivered  pursuant to any exercise of an Option until
      payment in full of the Option  Price  therefor is received by the Company.
      Such  payment  may be made in whole or in part in cash or,  to the  extent
      permitted  by the  Committee  at or  after  the  award of the  Option,  by
      delivery of a note or shares of Common  Stock  owned by the  optionholder,
      valued  at  their  Fair  Market  Value  on the  date of  delivery,  by the
      reduction  of the shares of Common  Stock that the  optionholder  would be
      entitled to receive upon exercise of the Option,  such shares to be valued
      at their Fair  Market  Value on the date of  exercise,  less their  Option
      Price  (a   so-called   "cashless   exercise"),   or  such  other   lawful
      consideration as the Committee may determine. In addition, an optionholder
      may engage in a successive  exchange (or series of exchanges) in which the
      shares of Common Stock that such  optionholder is entitled to receive upon
      the  exercise of an Option may be  simultaneously  utilized as payment for
      the exercise of an additional Option or Options.

(e)   The Committee  may provide for the  automatic  award of an Option upon the
      delivery  of shares to the  Company  in payment of an Option for up to the
      number of shares so delivered.


7.  General Provisions Applicable to Awards
    ---------------------------------------

(a)   Documentation.  Each Award under the Plan shall be  evidenced by a writing
      --------------
      delivered to the Participant  specifying the terms and conditions  thereof
      and containing such other terms and conditions not  inconsistent  with the
      provisions of the Plan as the Committee  considers  necessary or advisable
      to achieve  the  purposes of the Plan or comply  with  applicable  tax and
      regulatory laws and accounting principles.

(b)   Committee Discretion.  The terms of each Award need not be identical,  and
      ---------------------
      the Committee need not treat Participants  uniformly.  Except as otherwise
      provided by the Plan or a particular Award, any determination with respect
      to an Award  may be made by the  Committee  at the time of award or at any
      time thereafter.

(c)   Settlement.  The Committee shall  determine  whether Awards are settled in
      -----------
      whole or in part in cash,  Common Stock,  other securities of the Company,
      Awards or other property.

                                       39

<PAGE>

(d)   Termination of Employment.  The Committee shall determine the effect on an
      --------------------------  
      Award of  the  disability,  death,  retirement  or  other  termination  of
      employment of a Participant and the extent to which, and the period during
      which,  the  Participant's  legal  representative,  guardian or Designated
      Beneficiary may receive payment of an Award or exercise rights thereunder.

(e)   Change in Control.  In order to preserve a  Participant's  rights under an
      ------------------
      Award in the event of a change in control of the Company, the Committee in
      its  discretion  may,  at the  time  an  Award  is  made  or at  any  time
      thereafter, take one or more of the following actions: (i) provide for the
      acceleration  of any time period  relating  to the  exercise of the Award,
      (ii) provide for the purchase of the Award upon the Participant's  request
      for an amount of cash or other property that could have been received upon
      the exercise of the Award had the Award been currently exercisable,  (iii)
      adjust the terms of the Award in a manner  determined  by the Committee to
      reflect the change in control,  (iv) cause the Award to be assumed, or new
      rights  substituted  therefor,  by another entity,  or (v) make such other
      provision  as the  Committee  may  consider  equitable  and  in  the  best
      interests of the Company.

(f)   Withholding.  The Participant shall pay to the Company,  or make provision
      ------------
      satisfactory to the Committee for payment of, any taxes required by law to
      be withheld in respect of Awards  under the Plan no later than the date of
      the event creating the tax liability. In the Committee's discretion,  such
      tax obligations may be paid in whole or in part in shares of Common Stock,
      including  shares  retained  from the Award  creating the tax  obligation,
      valued at their Fair Market Value on the date of delivery. The Company and
      its affiliates  may, to the extent  permitted by law,  deduct any such tax
      obligations from any payment of any kind otherwise due to the Participant.

(g)   Amendment of Award.  The  Committee  may amend,  modify or  terminate  any
      -------------------
      outstanding Award,  including  substituting  therefor another Award of the
      same or a different type, changing the date of exercise, provided that the
      Participant's  consent  to  such  action  shall  be  required  unless  the
      Committee  determines  that the action,  taking  into  account any related
      action, would not materially and adversely affect the Participant.


8.  Miscellaneous
    -------------

(a)   No Right To  Employment.  No  person  shall  have any claim or right to be
      ------------------------
      granted  an Award,  and the grant of an Award  shall not be  construed  as
      giving a  Participant  the  right to  continued  employment.  The  Company
      expressly  reserves  the right at any time to dismiss a  Participant  free
      from any liability or claim under the Plan,  except as expressly  provided
      in the applicable Award.

(b)   No Rights As  Stockholder.  Subject to the  provisions  of the  applicable
      --------------------------
      Award, no Participant or Designated Beneficiary shall have any rights as a
      stockholder  with respect to any shares of Common Stock to be  distributed
      under the Plan until he or she becomes the holder thereof.

(c)   Governing  Law.  The  provisions  of the  Plan  shall be  governed  by and
      ---------------
      interpreted in accordance with the laws of the State of Delaware.

                                       39


<PAGE>

(d)   Indemnity. Neither the Board nor the Committee, nor any members of either,
      ----------
      nor any  employees  of the  Company or any  parent,  subsidiary,  or other
      affiliate,  shall  be  liable  for  any  act,  omission,   interpretation,
      construction or determination  made in good faith in connection with their
      responsibilities  with respect to this Plan, and the Company hereby agrees
      to indemnify the members of the Board,  the members of the Committee,  and
      the employees of the Company and its parent or  subsidiaries in respect of
      any claim, loss,  damage, or expense  (including  reasonable counsel fees)
      arising  from any such  act,  omission,  interpretation,  construction  or
      determination to the full extent permitted by law.

(e)   Effective  Date of Plan. The effective date of this Plan shall be the date
      ------------------------
      of  adoption  by the Board of  Directors.  If the Plan is  subject  to the
      approval of the stockholders under paragraph (f) below, upon such approval
      it  shall  be  effective  as of the  date  of  adoption  by the  Board  of
      Directors. The Committee may grant Awards under the Plan prior to any such
      required  stockholder  approval,  and any such Awards  which are of a type
      that require stockholder approval shall become effective as of the date of
      grant upon receipt of such approval.

(f)   Stockholder Approval.  The adoption of this Plan, or any amendment hereto,
      ---------------------
      shall be subject to approval by  stockholders  only to the extent required
      by (i) the  Code,  (ii)  the  rules  under  Section  16 of the  Securities
      Exchange  Act of 1934,  as amended  from time to time,  (iii) rules of any
      stock  exchange or  over-the-counter  stock  market,  or (iv) as otherwise
      required  by law.  Any such  approval  shall be  obtained  within the time
      required by such law or rule. Any stockholder approval of this Plan or any
      amendment  so  required  shall  mean  the  affirmative  vote of at least a
      majority of the shares of capital  stock present and entitled to vote at a
      duly held  meeting of  stockholders,  unless a greater vote is required by
      state corporation law or the law or rule requiring  stockholder  approval,
      in which case such greater requirement shall apply.

(g)   Amendment of Plan. The Board of the Company may at any time, and from time
      ------------------
      to  time,  amend,  suspend  or  terminate  this  Plan in whole or in part;
      provided,  however,  that the  Board may not  modify  the Plan in a manner
      requiring the approval of  stockholders  under  paragraph (f) above unless
      such approval is obtained to the extent required.

(h)   Term of  Plan.  This  Plan  shall  terminate  ten  years  from the date of
      --------------
      adoption  by the  Board,  and no Award  shall be  granted  under this Plan
      thereafter,  but such termination  shall not affect the validity of Awards
      granted prior to the date of termination.

                                       40

<PAGE>


                                    EXHIBIT C

                             BOSTON BIOMEDICA, INC.

                        1999 EMPLOYEE STOCK PURCHASE PLAN

1. Purpose.

      The Boston Biomedica,  Inc. 1999 Employee Stock Purchase Plan (the "Plan")
is intended to provide a method whereby employees of Boston Biomedica, Inc. (the
"Company")  will have an  opportunity  to acquire a proprietary  interest in the
Company  through the purchase of shares of the  Company's  $.01 par value common
stock (the "Common Stock").  It is the intention of the Company to have the Plan
qualify as an "employee  stock  purchase plan" under Section 423 of the Internal
Revenue Code of 1986, as amended (the "Code"). The provisions of the Plan shall,
accordingly,  be construed so as to extend and limit  participation  in a manner
consistent with the requirements of that Section of the Code.

2. Eligible Employees.

      (a) All employees of the Company or any of its participating  subsidiaries
who have  completed  twelve  consecutive  months,  or two years,  whether or not
consecutive,  of  employment  with  the  Company  or any  of  its  participating
subsidiaries  on or before the first day of the applicable  Offering  Period (as
defined below) shall be eligible to receive  options under this Plan to purchase
the Company's  Common Stock. In no event may an employee be granted an option if
such employee,  immediately  after the option is granted,  owns stock possessing
five (5%)  percent or more of the total  combined  voting  power or value of all
classes  of stock of the  Company  or of its parent  corporation  or  subsidiary
corporation as the terms "parent  corporation" and "subsidiary  corporation" are
defined in Section 424(e) and (f) of the Code. For purposes of determining stock
ownership  under this  paragraph,  the rules of Section 424(d) of the Code shall
apply and stock which the employee may purchase under outstanding  options shall
be treated as stock owned by the employee. 

      (b) For the purpose of this Plan,  the term employee  shall not include an
employee whose customary  employment is for less than twenty (20) hours per week
or is for less than five (5) months in any calendar  year.  

3. Stock Subject to the Plan.

      The stock subject to the options granted  hereunder shall be shares of the
Company's  authorized  but  unissued  Common  Stock or shares  of  Common  Stock
reacquired by the Company,  including shares  purchased in the open market.  The
aggregate  number of shares which may be issued pursuant to the Plan is 250,000,
subject to increase or decrease by reason of stock split-ups, reclassifications,
stock  dividends,  changes in par value and the like. If the number of shares of
Common Stock reserved and available for any Offering  Period (as defined hereto)
is insufficient to satisfy all purchase  requirements  for that Offering Period,
the reserved and available  shares for that Offering Period shall be apportioned
among participating employees in proportion to their options.

                                       41
<PAGE>


4. Offering Periods and Stock Options.

      (a) Six month periods during which payroll  deductions will be accumulated
under the Plan ("Offering Periods") will commence on January 1st and July 1st of
each year and end on June 30 or  December  31 next  following  the  commencement
date.  The  first  Offering  Period  shall  commence  on July 1, 1999 and end on
December 31, 1999.  Each Offering  Period includes only regular pay days falling
within  it. The  Offering  Commencement  Date is the first day of each  Offering
Period.  The  Offering  Termination  Date is the  applicable  date on  which  an
Offering Period ends under this Section.

      (b) On each  Offering  Commencement  Date,  the Company will grant to each
eligible employee who is then a participant in the Plan an option to purchase on
the Offering  Termination Date at the Option Exercise Price, as provided in this
paragraph  (b),  that number of full  shares of Common  Stock  reserved  for the
purpose of the Plan as his or her accumulated payroll deductions on the Offering
Termination  Date  (including any amount carried  forward  pursuant to Article 8
hereof) will pay for at the Option Exercise  Price;  provided that such employee
remains eligible to participate in the Plan throughout such Offering Period. The
Option  Exercise  Price  for each  Offering  Period  shall be the  lesser of (i)
eighty-five  percent  (85%) of the fair market  value of the Common Stock on the
Offering Commencement Date, or (ii) eighty-five percent (85%) of the fair market
value of the Common  Stock on the  Offering  Termination  Date,  in either  case
rounded up to avoid  fractions  other than  multiples of 1/8. In the event of an
increase or decrease in the number of outstanding shares of Common Stock through
stock split-ups,  reclassifications,  stock dividends,  changes in par value and
the like, an  appropriate  adjustment  shall be made in the number of shares and
Option  Exercise  Price per  share  provided  for  under  the Plan,  either by a
proportionate increase in the number of shares and proportionate decrease in the
Option Exercise Price per share, or by a proportionate decrease in the number of
shares and a  proportionate  increase in the Option Exercise Price per share, as
may be required to enable an eligible  employee who is then a participant in the
Plan to acquire on the Offering  Termination  Date that number of full shares of
Common Stock as his accumulated  payroll deductions on such date will pay for at
the Option Exercise Price, as so adjusted.

      (c) For purposes of this Plan,  the term "fair  market  value" on any date
means, if the Common Stock is listed on a national  securities exchange or is on
the NASDAQ National  Market System  ("NASDAQ NMS"),  the average of the high and
low  sales  prices  of the  Common  Stock on such  date on such  exchange  or as
reported on NASDAQ NMS or, if the Common Stock is traded in the over-the-counter
securities  market,  but not on the NASDAQ NMS,  the average of the high and low
bid quotations for the Common Stock on such date,  each as published in the Wall
Street  Journal.  If no  shares  of Common  Stock  are  traded  on the  Offering
Commencement  Date or Offering  Termination  Date, the fair market value will be
determined  by taking the average of the fair market  values on the  immediately
preceding and the next  following  business days on which shares of Common Stock
are traded.

      (d) For purposes of this Plan the term "business day" as used herein means
a day on  which  there is  trading  on the  NASDAQ  NMS or such  other  national
securities exchange on which the Common Stock is listed.

      (e) No  employee  shall be granted an option  which  permits his rights to
purchase Common Stock under the Plan and any similar plans of the Company or any
parent or  participating  subsidiary  corporations  to  accrue  at a rate  which
exceeds $25,000 of fair market value of such 

                                       42
<PAGE>

stock  (determined at the time such option is granted) for each calendar year in
which such option is  outstanding  at any time. The purpose of the limitation in
the  preceding  sentence is to comply with and shall be construed in  accordance
with Section 423(b)(8) of the Code.

5. Exercise of Option.

      Each eligible  employee who  continues to be a participant  in the Plan on
the  Offering  Termination  Date  shall be deemed to have  exercised  his or her
option on such date and shall be deemed to have  purchased from the Company such
number of full shares of Common  Stock  reserved  for the purpose of the Plan as
his or her accumulated  payroll deductions on such date, plus any amount carried
forward pursuant to Article 8 hereof, will pay for at the Option Exercise Price,
but in no event may an  employee  purchase  shares of Common  Stock in excess of
1,250 shares of Common Stock on any Offering  Termination Date. If a participant
is not an employee on the Offering  Termination  Date and throughout an Offering
Period,  he or she shall not be  entitled to  exercise  his or her  option.  All
options  issued  under the Plan shall,  unless  exercised  as set forth  herein,
expire at the end of the Offering  Termination Date with respect to the Offering
Period during which such options were issued.

6. Authorization for Entering Plan.

      (a) An eligible  employee may enter the Plan by filling  out,  signing and
delivering  to the Chief  Financial  Officer of the  Company or his  designee an
authorization ("Authorization"):

      i.    stating the amount to be deducted regularly from his or her pay;

      ii.   authorizing  the  purchase of stock for him or her in each  Offering
            Period in accordance with the terms of the Plan;

      iii.  specifying the exact name in which Common Stock purchased for him or
            her is to be issued in accordance with Article 11 hereof; and

      iv.   at the  discretion  of the employee in  accordance  with Article 14,
            designating a beneficiary  who is to receive any Common Stock and/or
            cash in the event of his or her death.

Such  Authorization  must be  received  by the Chief  Financial  Officer  of the
Company or his  designee  at least ten (10)  business  days  before an  Offering
Commencement Date.

      (b) The Company will  accumulate and hold for the  employee's  account the
amounts  deducted  from  his or her  pay.  No  interest  will be  paid  thereon.
Participating  employees  may not make any  separate  cash  payments  into their
account.

      (c) Unless an employee  files a new  Authorization  or withdraws  from the
Plan, his or her deductions and purchases under the  Authorization he or she has
on file under the Plan will  continue as long as the Plan remains in effect.  An
employee may increase or decrease the amount of his or her payroll deductions as
of the next Offering Commencement Date by filling out, signing and delivering to
the Chief Financial Officer of the Company or his designee a new  Authorization.
Such new  Authorization  must be received by the Chief Financial  Officer of the
Company or his designee at least ten (10)  business days before the date of such
next Offering Commencement Date.

                                       43
<PAGE>

1. Allowable Payroll Deductions.

      An employee may authorize payroll deductions in any whole dollar amount up
to but not  more  than ten  percent  (10%)  of his or her  base  pay;  provided,
however,  that the minimum  deduction in respect of any payroll  period shall be
one  percent  (1%) of his or her base pay but in no event less than ten  dollars
($10); and provided further that the maximum percentage shall be reduced to meet
the  requirements of Section 4(e) hereof.  Base pay means regular  straight-time
earnings and, if applicable,  commissions,  but excluding payments for overtime,
bonuses, and other special payments.

2. Unused Payroll Deductions.

      Only full shares of Common Stock may be purchased.  Any balance  remaining
in an  employee's  account after a purchase will be reported to the employee and
will be carried forward to the next Offering Period.  However,  in no event will
the amount of the  unused  payroll  deductions  carried  forward  from a payroll
period exceed the Option Exercise Price per share for the immediately  preceding
Offering  Period.  If for any  Offering  Period  the  amount of  unused  payroll
deductions  should exceed the Option Exercise Price per share, the amount of the
excess  for any  participant  shall be  refunded  to such  participant,  without
interest.

3. Change in Payroll Deductions.

      Deductions may not be increased or decreased during an Offering Period.

4. Withdrawal from the Plan.

      (a) An employee may  withdraw  from the Plan and withdraw all but not less
than all of the payroll deductions credited to his or her account under the Plan
at any time prior to the Offering Termination Date by delivering a notice to the
Chief Financial  Officer of the Company or his designee (a "Withdrawal  Notice")
in which event the Company  will  promptly  refund  without  interest the entire
balance of such employee's  deductions not  theretofore  used to purchase Common
Stock under the Plan.

      (b) If an employee  withdraws from the Plan,  the employee's  rights under
the Plan will be terminated and no further  payroll  deductions will be made. To
reenter,  such an  employee  must  file a new  Authorization  at least  ten (10)
business days before the next Offering  Commencement  Date.  Such  Authorization
will become  effective for the Offering  Period that  commences on such Offering
Commencement Date.  Notwithstanding the foregoing,  employees who are subject to
Section 16 of the Securities Exchange Act of 1934, as amended, who withdraw from
the Plan may not  reenter  the Plan until the next  Offering  Commencement  Date
which is at least six months following the date of such withdrawal.

5. Issuance of Stock.

      Upon  written  request,  certificates  for Common Stock will be issued and
delivered to  participants  as soon as practicable  after each Offering  Period.
Common  Stock  purchased  under the Plan will be issued  only in the name of the
employee, or in the case of employees who are not

                                       44
<PAGE>

subject to Section 16 of the Securities Exchange Act of 1934, as amended, if the
employee's  Authorization so specifies,  in the name of the employee and another
person of legal age as joint tenants with rights of survivorship.  The Committee
may require that shares be held on deposit with a participating broker or agent.

6. No Transfer or Assignment of Employee's Rights.

      An  employee's  rights under the Plan are his or hers alone and may not be
transferred  or  assigned  to, or availed of by,  any other  person.  Any option
granted to an employee may be exercised  only by him or her,  except as provided
in Article 13 in the event of an employee's death.

7. Termination of Employee's Rights.

      (a)  Except  as set forth in the last  paragraph  of this  Article  13, an
employee's  rights under the Plan will  terminate when he or she ceases to be an
employee because of retirement,  resignation,  lay-off, discharge, death, change
of status,  failure to remain in the customary employ of the Company for greater
than twenty (20) hours per week,  or for any other reason.  A Withdrawal  Notice
will be  considered  as having been received from the employee on the day his or
her employment  ceases,  and all payroll  deductions not used to purchase Common
Stock will be refunded.

      (b) If an  employee's  payroll  deductions  are  interrupted  by any legal
process, a Withdrawal Notice will be considered as having been received from him
or her on the day the interruption occurs.

      (c) Upon termination of the participating employee's employment because of
death,  the  employee's  beneficiary  (as  defined in Article 14) shall have the
right to elect,  by written notice given to the Chief  Financial  Officer of the
Company or his  designee  prior to the  expiration  of the sixty (60) day period
commencing  with the date of the death of the employee,  either (i) to withdraw,
without  interest,  all of the payroll  deductions  credited  to the  employee's
account  under the Plan,  or (ii) to  exercise  the  employee's  option  for the
purchase  of  shares  of  Common  Stock on the next  Offering  Termination  Date
following  the date of the  employee's  death for the purchase of that number of
full  shares of Common  Stock  reserved  for the  purpose  of the Plan which the
accumulated  payroll  deductions  in the  employee's  account at the date of the
employee's death will purchase at the applicable  Option Exercise Price (subject
to the maximum  number set forth in Article  5), and any excess in such  account
will be returned to said  beneficiary.  In the event that no such written notice
of election shall be duly received by the Chief Financial Officer of the Company
or his designee,  the beneficiary shall  automatically be deemed to have elected
to withdraw the payroll  deductions  credited to the  employee's  account at the
date of the  employee's  death  and the  same  will  be  paid  promptly  to said
beneficiary, without interest.

8. Designation of Beneficiary.

      A participating  employee may file a written  designation of a beneficiary
who is to receive any Common Stock and/or cash in case of his or her death. Such
designation of beneficiary may 

                                       45


<PAGE>

be changed by the  employee at any time by written  notice.  Upon the death of a
participating  employee and upon receipt by the Company of proof of the identity
and existence at the employee's death of a beneficiary validly designated by him
under the Plan,  the Company shall deliver such Common Stock and/or cash to such
beneficiary.  In the event of the death of a  participating  employee and in the
absence of a beneficiary  validly designated under the Plan who is living at the
time of such  employee's  death,  the Company  shall  deliver  such Common Stock
and/or cash to the executor or administrator  of the estate of the employee,  or
if, to the knowledge of the Company,  no such executor or administrator has been
appointed,  the Company,  in the discretion of the  Committee,  may deliver such
Common Stock and/or cash to the spouse or to any one or more  dependents  of the
employee as the Committee may  designate.  No  beneficiary  shall,  prior to the
death  of the  employee  by whom  he or she has  been  designated,  acquire  any
interest in the Common Stock or cash credited to the employee under the Plan.

9. Termination and Amendments to Plan.

      (a) The  Plan may be  terminated  at any  time by the  Company's  Board of
Directors,   effective  on  the  next  following   Offering   Termination  Date.
Notwithstanding  the  foregoing,  it will  terminate  when all of the  shares of
Common Stock  reserved for the  purposes of the Plan have been  purchased.  Upon
such  termination or any other  termination of the Plan, all payroll  deductions
not used to purchase Common Stock will be refunded without interest.

      (b) The Board of Directors  reserves the right to amend the Plan from time
to time in any respect; provided,  however, that no amendment shall be effective
without  stockholder  approval  if the  amendment  would,  except as provided in
Articles  3, 4, 24 and 25,  increase  the  aggregate  number of shares of Common
Stock to be offered under the Plan or change the class of employees  eligible to
participate under the Plan.

10. Limitations of Sale of Stock Purchased Under the Plan.

      Common  Stock  purchased  under the Plan by  employees  who are subject to
Section 16 of the Securities  Exchange Act of 1934, as amended,  may not be sold
for six (6) months after the Offering Termination Date on which such shares were
purchased,  unless  such  transaction  shall be exempt from Rule 16b-3 under the
Securities Exchange Act of 1934, as amended. Thereafter, such employees may sell
Common  Stock  purchased  under  the  Plan  at  any  time.  Notwithstanding  the
foregoing, because of certain Federal tax requirements, all employees will agree
by entering  the Plan,  promptly  to give the Company  notice of any such Common
Stock disposed of within two years after the Offering Commencement Date on which
the related  option was granted  showing the number of such shares  disposed of.
The employee  assumes the risk of any market  fluctuations  in the price of such
Common Stock.  Certificates  representing shares of Common Stock purchased under
the Plan will bear a legend  reflecting the  restrictions  on transfer set forth
herein.

11. Company's Payment of Expenses Related to Plan.

      The Company  will bear all costs of  administering  and  carrying  out the
Plan.

12. Participating Subsidiaries.

      The term  "participating  subsidiaries"  shall mean any  subsidiary of the
Company  which is  designated  by the  Committee  (as  defined in Article 19) to
participate in the Plan. The Committee

                                       46
<PAGE>

shall  have the  power to make  such  designation  before  or after  the Plan is
approved by the stockholders. 

13. Administration of the Plan.

      (a)  The  Plan  shall  be  administered  by a  committee  of  non-employee
Directors  as that term is defined in Rule 16b-3 under the  Securities  Exchange
Act of 1934,  as amended,  appointed  by the Board of  Directors of the Company,
which shall be the  Company's  Compensation  Committee  (the  "Committee").  The
Committee  shall consist of not less than two members of the Company's  Board of
Directors.  The Board of Directors may from time to time remove members from, or
add members to, the  Committee.  Vacancies on the Committee,  howsoever  caused,
shall be filled by the Board of Directors.  No member of the Committee  shall be
eligible to participate in the Plan while serving as a member of the Committee.

      (b) The Committee  shall select one of its members as chairman,  and shall
hold meetings at such times and places as it may  determine.  Acts by a majority
of the Committee, or acts reduced to or approved in writing by a majority of the
members of the Committee, shall be the valid acts of the Committee.

      (c) The interpretation and construction by the Committee of any provisions
of the Plan or of any option granted under it shall be final.  The Committee may
from time to time adopt such rules and  regulations for carrying out the Plan as
it may  deem  best.  With  respect  to  persons  subject  to  Section  16 of the
Securities and Exchange Act of 1934, as amended, transactions under the Plan are
intended  to  comply  with  all  applicable  conditions  of  Rule  16b-3  or its
successors  under said Act. To the extent any provision of the Plan or action by
the  Committee  fails to so  comply,  it shall be deemed  null and void,  to the
extent permitted by law and deemed advisable by that Committee.

      (d) Promptly after the end of each Offering  Period,  the Committee  shall
prepare  and  distribute  to each  participating  employee  in the Plan a report
containing  the  amount  of the  participating  employee's  accumulated  payroll
deductions as of the Offering  Termination  Date, the Option  Exercise Price for
such  Offering  Period,  the number of shares of Common  Stock  purchased by the
participating  employee with the participating  employee's  accumulated  payroll
deductions, and the amount of any unused payroll deductions either to be carried
forward to the next Offering Period, or returned to the  participating  employee
without interest.

      (e) No member of the Board of Directors or the  Committee  shall be liable
for any action or  determination  made in good faith with respect to the Plan or
any option  granted  under it. The Company  shall  indemnify  each member of the
Board of Directors and the Committee to the fullest extent permitted by law with
respect to any claim,  loss, damage or expense  (including counsel fees) arising
in connection with their responsibilities under this Plan.

14. Optionees Not Stockholders.

      Neither the granting of an option to an employee nor the  deductions  from
his or her pay shall  constitute such employee a stockholder of the Company with
respect  to the shares  covered  by such  option  until  such  shares  have been
purchased by and issued to him or her.

                                       47

<PAGE>

15. Application of Funds.

      The  proceeds  received  by the  Company  from  the sale of  Common  Stock
pursuant  to  options  granted  under  the Plan  may be used  for any  corporate
purposes,  and the Company  shall not be obligated  to  segregate  participating
employees' payroll deductions.

16. Governmental Regulation.

      The  Company's  obligation  to sell and  deliver  shares of the  Company's
Common  Stock  under this Plan is subject to the  approval  of any  governmental
authority  required in connection  with the  authorization,  issuance or sale of
such stock.

      In this regard, the Board of Directors may, in its discretion,  require as
a condition to the exercise of any option that a  Registration  Statement  under
the  Securities  Act of 1933,  as amended,  with respect to the shares of Common
Stock reserved for issuance upon exercise of the option shall be effective.

17. Transferability.

      Neither  payroll  deductions  credited  to an  employee's  account nor any
rights  with regard to the  exercise of an option or to receive  stock under the
Plan may be assigned, transferred,  pledged, or otherwise disposed of in any way
by the employee.  Any such  attempted  assignment,  transfer,  pledge,  or other
disposition shall be without effect,  except that the Company may treat such act
as an election to withdraw funds in accordance with Article 10.

18. Effect of Changes of Common Stock.

      If the Company  should  subdivide or reclassify the Common Stock which has
been or may be optioned under the Plan, or should  declare  thereon any dividend
payable in shares of such Common  Stock,  or should  take any other  action of a
similar nature affecting such Common Stock,  then the number and class of shares
of Common Stock which may  thereafter  be optioned (in the  aggregate and to any
individual participating employee) shall be adjusted accordingly.

19. Merger or Consolidation.

      If the Company should at any time merge into or  consolidate  with another
corporation,  the Board of Directors may, at its election,  either (i) terminate
the Plan and refund without  interest the entire  balance of each  participating
employee's payroll  deductions,  or (ii) entitle each participating  employee to
receive on the  Offering  Termination  Date upon the exercise of such option for
each  share of Common  Stock as to which  such  option  shall be  exercised  the
securities  or property  to which a holder of one share of the Common  Stock was
entitled upon and at the time of such merger or consolidation,  and the Board of
Directors shall take such steps in connection with such merger or  consolidation
as the Board of Directors  shall deem necessary to assure that the provisions of
this  Article  25 shall  thereafter  be  applicable,  as  nearly  as  reasonably
possible.  A sale of all or substantially all of the assets of the Company shall
be deemed a merger or consolidation for the foregoing purposes.

                                       48
<PAGE>



20. Withholding of Additional Federal Income Tax.

      The Company will undertake such withholding in connection with the Plan as
it determines appropriate, in its sole discretion.

21. Approval of Stockholders.

      The Plan shall not take effect until approved by the holders of a majority
of the  outstanding  shares of Common Stock of the Company,  which approval must
occur no later than the end of the first Offering Period after the date the Plan
is  adopted by the Board of  Directors.  Options  may be granted  under the Plan
prior and subject to such stockholder  approval.  If the Plan is not so approved
by the stockholders,  all payroll deductions from participating  employees shall
be returned without interest and all options so granted shall terminate.

                                       49


<PAGE>



PROXY                        BOSTON BIOMEDICA, INC.                        PROXY


      The  undersigned  hereby  appoints  Richard  T.  Schumacher  and  Kevin W.
Quinlan,  and each of them,  acting  singly,  with full  power of  substitution,
attorneys,  and proxies to represent the undersigned at the 1999 Special Meeting
in Lieu of Annual Meeting of Stockholders of Boston  Biomedica,  Inc. to be held
on Tuesday,  July 20, 1999, and at any adjournment or adjournments thereof, with
all power which the undersigned would possess if personally present, and to vote
all  shares  of stock  which the  undersigned  may be  entitled  to vote at said
meeting upon the matters set forth in the Notice of and Proxy  Statement for the
Meeting in accordance  with the following  instructions  and with  discretionary
authority  upon such other matters as may come before the Meeting.  All previous
proxies are hereby revoked.

THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS. IT WILL BE VOTED AS
DIRECTED BY THE UNDERSIGNED  AND IF NO DIRECTION IS INDICATED,  IT WILL BE VOTED
FOR THE  ELECTION OF THE  NOMINEES AS  DIRECTORS,  FOR THE PROPOSAL TO AMEND THE
BOSTON BIOMEDICA, INC. EMPLOYEE STOCK OPTION PLAN, FOR THE PROPOSAL TO ADOPT THE
BOSTON BIOMEDICA, INC. 1999 NONQUALIFIED STOCK OPTION PLAN, AND FOR THE PROPOSAL
TO ADOPT THE BOSTON BIOMEDICA, INC. 1999 STOCK PURCHASE PLAN.

                  Continued, and to be signed, on reverse side
         (Please fill in the reverse side and mail in enclosed envelope)

                                       50

<PAGE>

[x] Please mark votes as in this example.

The Board of  Directors  recommends  a vote FOR the  election of the nominees as
Directors.

1. Election of Directors:

Nominees:  Richard T. Schumacher  and  Kevin W. Quinlan

[ ] FOR THE NOMINEES      [ ] WITHHOLD AUTHORITY to vote for the nominees

The Board of Directors recommends a vote FOR Proposal 2.

2. Amend the Boston Biomedica Inc. Employee Stock Option Plan:

[ ] FOR [ ] AGAINST  [ ] ABSTAIN

The Board of Directors recommends a vote FOR Proposal 3.

3. Adopt the Boston Biomedica Inc. 1999 Nonqualified Stock Option Plan:

[ ] FOR [ ] AGAINST  [ ] ABSTAIN

The Board of Directors recommends a vote FOR Proposal 4.

4. Adopt the Boston Biomedica Inc. 1999 Employee Stock Purchase Plan:

[ ] FOR [ ] AGAINST  [ ] ABSTAIN


INSTRUCTIONS:  TO WITHHOLD  AUTHORITY TO VOTE FOR ANY  INDIVIDUAL  NOMINEE WRITE
THAT NOMINEE'S NAME IN THE SPACE PROVIDED ABOVE.
- --------------------------------------------------------------------------------


                                                    MARK HERE FOR ADDRESS CHANGE
                                                    AND NOTE AT LEFT

                                                       [ ]


(Signatures  should  be  the  same  as  the  name  printed  hereon.   Executors,
administrators,  trustees,  guardians,  attorneys,  and officers of corporations
should add their titles when signing).

Signature: ____________________Title: _________________________Date: __________


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Signature: ____________________Title: _________________________Date: __________

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<PAGE>


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