BIOPOOL INTERNATIONAL INC
10QSB, EX-4.1, 2000-11-14
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                                                     EXHIBIT 4.1

                           RIGHTS AGREEMENT AMENDMENT


     This  Rights  Agreement  Amendment,   dated  as  of  March  1,  2000  (this
"Amendment"),  to the Rights  Agreement,  dated as of June 12, 1998 (the "Rights
Agreement"),  between Biopool  International,  Inc., a Delaware corporation (the
"Company") and American  Stock  Transfer & Trust  Company,  as Rights Agent (the
"Rights Agent").

     The Company and the Rights Agent have heretofore executed and delivered the
Rights Agreement.  Pursuant to Section 28 of the Rights  Agreement,  the Company
and the  Rights  Agent may from  time to time  supplement  or amend  the  Rights
Agreement in accordance with the provisions of Section 28 thereof.

     In consideration of the foregoing  premises and mutual agreements set forth
in the Rights  Agreement,  as amended,  and this  Amendment,  the parties hereto
agree as follows:

     1.   The  definition  of  "Acquiring  Person"  in  Section 1 of the  Rights
Agreement is hereby amended and restated to read in its entirety as follows:

               "`Acquiring  Person'  shall mean (i) any  Person (as  hereinafter
          defined) who is an Adverse Person (as  hereinafter  defined),  or (ii)
          any Person who or which,  together with all Affiliates (as hereinafter
          defined)  and  Associates  (as  hereinafter  defined) of such  Person,
          shall,  subsequent  to the  Declaration  Date,  become the  Beneficial
          Owners (as hereinafter defined) of 15% or more of the shares of Common
          Stock then outstanding, but shall not include (x) an Exempt Person (as
          hereinafter  defined) or (y) any Person who becomes a Beneficial Owner
          of 15% or more of the share of Common  Stock then  outstanding  solely
          because  (1) of a change in the  aggregate  number of shares of Common
          Stock  outstanding  since the last date on which such Person  acquired
          Beneficial Ownership of any shares of Common Stock, or (2) it acquired
          such  Beneficial   Ownership  in  the  good  faith  belief  that  such
          acquisition would not (A) cause such Beneficial  Ownership to equal or
          exceed 15% of the shares of Common Stock then  outstanding (or, in the
          case  of  Xtrana,  Inc.,  a  Delaware  corporation   ("Xtrana"),   the
          percentage Xtrana may hold without ceasing to be an Exempt Person) and
          such Person  relied in good faith in computing  the  percentage of its
          Beneficial  Ownership  on publicly  filed  reports or documents of the
          Company which are inaccurate or out-of-date,  or (B) otherwise cause a
          Distribution  Date or the  adjustment  provided  for in  Section 14 to
          occur. Notwithstanding clause (y) of the prior sentence, if any Person
          that is not an  Acquiring  Person  because  of the  operation  of such
          clause  (y) does not  reduce  its  Beneficial  Ownership  of shares of
          Common  Stock  to less  than  15%  (or,  in the  case of  Xtrana,  the
          percentage  Xtrana may hold without ceasing to be an Exempt Person) by
          the close of business on the fifth  Business Day after notice from the
          Company  (the date of notice  being the first day) that such  Person's
          Beneficial  Ownership of Common stock so equals or exceeds 15% (or, in
          the case of Xtrana, the percentage Xtrana. may hold without ceasing to
          be an  Exempt  Person),  such  Person  shall,  at the end of such five
          Business Day period,  become an Acquiring Person (and clause (y) shall
          no longer apply to such Person). For purposes of this definition,  the
          determination  whether  any  Person  acted  in "good  faith"  shall be
          conclusively determined by the Board of Directors, acting by a vote of
          those  directors of the Company  whose  approval  would be required to
          redeem the Rights under Section 25."



<PAGE>


     2.   The definition of "Exempt Person" in Section 1 of the Rights Agreement
is hereby amended and restated to read in its entirety as follows:

               "`Exempt  Person'  shall  include  (i)  the  Company,   (ii)  any
          Subsidiary (as hereinafter defined) of the Company, (iii) any employee
          benefit plan of the Company or any of its Subsidiaries,  or any entity
          holding  shares of Common  Stock  which was  organized,  appointed  or
          established  by the  Company or any  Subsidiary  of the Company for or
          pursuant to the terms of any such plan and (iv) Xtrana, so long as its
          aggregate  Beneficial  Ownership of Common Stock does not exceed 19.9%
          of Common  Stock  then  outstanding,  and so long as  Xtrana  does not
          acquire  any  additional  shares of Common  Stock or commence a tender
          offer or an  exchange  offer for  additional  shares of Common  Stock,
          other than in  connection  with the merger  described  in that certain
          Letter of Intent, dated March 10, 2000, between the Company and Xtrana
          (the "Letter of Intent")."

     3.   Section  3(a) of the  Rights  Agreement  is  amended  by  adding a new
sentence as the final  sentence  thereto,  which  shall read in its  entirety as
follows:

               "Notwithstanding   anything  in  this  Rights  Agreement  to  the
          contrary,  a  Distribution  Date shall not be deemed to have  occurred
          solely as a result of (i) the  approval,  execution or delivery of the
          Merger  Agreement  described  in the  Letter  of Intent  (the  "Merger
          Agreement")  or any of the  agreements or  instruments  required to be
          executed  and   delivered   in   connection   with  the   transactions
          contemplated  therein,  or (ii) the  consummation  of the  Merger  (as
          defined in the Merger Agreement)."

     4.   This Amendment  shall be governed by and construed in accordance  with
the laws of the State of Delaware.

     5.   This Amendment may be executed in any number of counterparts  and each
of such counterparts shall for all purposes be deemed an original,  and all such
counterparts shall together constitute but one and the same instrument.

     6.   Except as expressly  set forth  herein,  this  Amendment  shall not by
implication or otherwise  alter,  modify,  amend or in any way affect any of the
terms, conditions,  obligations, covenants or agreements contained in the Rights
Agreement,  all of which are  ratified  and  affirmed in all  respects and shall
continue in full force and effect.


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<PAGE>



         IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
duly executed as of the day and year first above written.


                                       BIOPOOL INTERNATIONAL, INC.



                                       By:    /s/ JOHN H. WHEELER
                                              ----------------------------------
                                       Title: Chief Executive Officer



                                       AMERICAN STOCK TRANSFER & TRUST COMPANY



                                       By:    /s/ WILBERT MYLES
                                              ----------------------------------
                                       Title: Vice President


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