NEOTHERAPEUTICS INC
NT 10-K, 2000-03-30
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                        UNITED STATES               OMB APPROVAL
             SECURITIES AND EXCHANGE COMMISSION     OMB NUMBER: 3235-0058
                    Washington, D.C. 20549          Expires: June 30, 1994
                                                    Estimated average burden
                         FORM 12b-25                hours per response....2.50

                                                    SEC File Number  000-28782
                                                                    -----------

                          NOTIFICATION OF LATE FILING

(Check One):
[X] Form 10-K    [ ] Form 20-F   [ ] Form 11-K   [ ] FORM 10-Q   [ ] Form N-SAR

    For Period Ended:              December 31, 1999
                      --------------------------------------------------------

[ ] Transition Report on Form 10-K           [ ] Transition Report on Form 10-Q
[ ] Transition Report on Form 20-F           [ ] Transition Report on Form N-SAR
[ ] Transition Report on Form 11-K

    For the Transition Period Ended:
                                     -----------------------------------------

Read Instruction (on back page) Before Preparing Form. Please Print or Type.

    Nothing in this form shall be construed to imply that the Commission has
verified any information contained herein.

    If the notification relates to a portion of the filing checked above,
identify the Item(s) to which the notification relates:

- ------------------------------------------------------------------------------

                       PART I -- REGISTRANT INFORMATION


NEOTHERAPEUTICS, INC.
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Full Name of Registrant


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Former Name if Applicable


157 TECHNOLOGY DRIVE
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Address of Principal Executive Office (Street and Number)


IRVINE, CA 92618
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City, State and Zip Code


                       PART II--RULES 12b-25(b) AND (c)

If the subject report could not be filed without unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following
should be completed.  (Check box if appropriate)

         [X]        (a)     The reasons described in reasonable detail in Part
                            III of this form could not be eliminated without
                            unreasonable effort or expense;

         [X]        (b)     The subject annual report, semi-annual report,
                            transition report on Form 10-K, Form 20-F, Form
                            11-K, Form N-SAR, or portion thereof, will be filed
                            on or before the fifteenth calendar day following
                            the prescribed due date; or the subject quarterly
                            report or transition report on Form 10-Q, or portion
                            thereof will be filed on or before the calendar day
                            following the prescribed due date; and

                    (c)     The accountant's statement or other exhibit required
                            by Rule 12b-25(c) has been attached if applicable.


                             PART III--NARRATIVE

State below in reasonable detail the reasons why Forms 10-K and Form 10-KSB,
20F, 11-K, 10-Q, and 10-QSB, N-SAR or the transition report portion thereof
could not be filed within the prescribed time period.

The Company operates with limited administrative personnel who, most recently,
were in the process of completing a major financial transaction. Accordingly,
resumption of efforts by these key persons to complete the Form 10-K in a timely
manner could not be successfully accomplished and the Company hereby requests
additional time in which to file its Form 10-K.

                                                 (ATTACH EXTRA SHEETS IF NEEDED)
                                                              SEC 1344 (11/91)
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PART IV - OTHER INFORMATION

(1)  Name and telephone number of person to contact in regard to this
     notification

             SAMUEL GULKO                     (949)              788-6700
     ----------------------------------   --------------   ---------------------

(2)  Have all other periodic reports required under Section 13 or 15(d) of the
     Securities Exchange Act of 1934 or Section 30 of the Investment Company Act
     of 1940 during the preceding 12 months (or for such shorter) period that
     the registrant was required to file such reports) been filed? If answer is
     no, identify report(s).
                                                                [X] Yes   [ ] No

     ---------------------------------------------------------------------------

(3)  Is it anticipated that any significant change in results of operations from
     the corresponding period for the last fiscal year will be reflected by the
     earnings statements to be included in the subject report or portion
     thereof?
                                                                [ ] Yes   [X] No

     If so, attach an explanation of the anticipated change, both narratively
     and quantitatively, and, if appropriate, state the reasons why a
     reasonable estimate of the results cannot be made.

- --------------------------------------------------------------------------------



- --------------------------------------------------------------------------------
                  (Name of Registrant as Specified in Charter)

has caused this notification to be signed on its behalf by the undersigned
hereunto duly authorized.


Date      March 30, 2000            By  /s/ SAMUEL GULKO
     ---------------------------        ----------------------------------------
                                        SAMUEL GULKO, CHIEF FINANCIAL OFFICER

INSTRUCTION: The form may be signed by an executive officer of the registrant or
by any other duly authorized representative. The name and title of the person
signing the form shall be typed or printed beneath the signature. If the
statement is signed on behalf of the registrant by an authorized representative
(other than an executive officer), evidence of the representative's authority to
sign on behalf of the registrant shall be filed with the form.


                                   ATTENTION
- --------------------------------------------------------------------------------
           Intentional misstatements or omissions of fact constitute
                Federal Criminal Violations (See 18 U.S.C. 1001).
- --------------------------------------------------------------------------------


                              GENERAL INSTRUCTIONS

1.   This form is required by Rule 12b-25 (17 CFR 240.12b-25) of the General
     Rules and Regulations under the Securities Exchange Act of 1934.

2.   One signed original and four conformed copies of this form and amendments
     thereto must be completed and filed with the Securities and Exchange
     Commission, Washington, D.C. 20549, in accordance with Rule 0-3 of the
     General Rules and Regulations under the Act. The information contained in
     or filed with the form will be made a matter of public record in the
     Commission files.

3.   A manually signed copy of the form and amendments thereto shall be filed
     with each national securities exchange on which any class of securities of
     the registrant is registered.

4.   Amendments to the notifications must also be filed on Form 12b-25 but need
     not restate information that has been correctly furnished. The form shall
     be clearly identified as an amended notification.



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