BIOSITE DIAGNOSTICS INC
SC 13D/A, 1997-03-07
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                     SECURITIES AND EXCHANGE COMMISSION
                           WASHINGTON, D.C. 20549
                     ___________________________________
                                SCHEDULE 13D
                               (RULE 13D-101)

                  UNDER THE SECURITIES EXCHANGE ACT OF 1934
                            (Amendment No. 1)<1>

                      BIOSITE DIAGNOSTICS INCORPORATED
- --------------------------------------------------------------------------------
                              (Name of issuer)

                    COMMON STOCK, PAR VALUE $0.01 PER SHARE
     ----------------------------------------------------------------------     
                       (Title of class of securities)

                               09094510
     ----------------------------------------------------------------------     
                               (CUSIP number)

                            KLAUS H. JANDER, ESQ.
                               ROGERS & WELLS
                               200 PARK AVENUE
                          NEW YORK, NEW YORK 10166
                               (212) 878-8001
     ----------------------------------------------------------------------
                (Name, address and telephone number of person
              authorized to receive notices and communications)

                              FEBRUARY 10, 1997
     ----------------------------------------------------------------------
           (Date of event which requires filing of this statement)

               If  the  filing  person  has previously filed a statement on
     Schedule 13G to report the acquisition  which  is  the subject of this
     Schedule 13D, and is filing this schedule because of  Rule 13d-1(b)(3)
     or (4), check the following box  <square>.


               NOTE.  Six copies of this statement, including all exhibits,
     should  be  filed with the Commission.  SEE Rule 13d-1 (a)  for  other
     parties to whom copies are to be sent.

                       (Continued on following pages)

                             (Page 1 of 5 Pages)






__________________________


     <1> The remainder  of  this cover page shall be filled out for a reporting
person's initial filing on this  form  with  respect  to  the  subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

     The information required on the remainder of this cover page  shall not be
deemed  to be "filed" for the purpose of Section 18 of the Securities  Exchange
Act of 1934  or otherwise subject to the liabilities of that section of the Act
but shall be subject  to  all  other  provisions  of  the Act (however, SEE the
NOTES.)



PAGE
<PAGE>
                                             SCHEDULE 13D

                                                             PAGE 2 OF 5 PAGES


<TABLE>
<CAPTION>
<S>            <C>                              <C>         <C>                                       <C>
  1            NAME OF REPORTING PERSON
               S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                      Merck KGaA
                   (Reporting person is a foreign corporation and does not have S.S. or I.R.S. identification number)

  2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                                     (A) <square>
                                                                                                     (B) <square>
  3            SEC USE ONLY

  4            SOURCE OF FUNDS*

                      OO
  5            CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(C) OR 2(E)   <square>

  6            CITIZENSHIP OR PLACE OF ORGANIZATION

                      Federal Republic of Germany
                                                7           SOLE VOTING POWER

                                                                   1,187,667
         NUMBER OF
          SHARES
       BENEFICIALLY
         OWNED BY
           EACH
         REPORTING
          PERSON
           WITH
                                                8           SHARED VOTING POWER

                                                                   0
                                                9           SOLE DISPOSITIVE POWER

                                                                   1,187,667
                                               10           SHARED DISPOSITIVE POWER

                                                                   0
 11            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON                              <square>

                      1,187,667
 12            CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*                    <square>
 13            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                     APPROXIMATELY 9.3%
 14            TYPE OF REPORTING PERSON*

                      CO
</TABLE>


                                 *SEE INSTRUCTIONS BEFORE FILLING OUT!

                    INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
            (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.


PAGE
<PAGE>
ITEM 3.   SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION
          -------------------------------------------------

          Immediately prior  to  the  IPO,  Merck KGaA  was  the beneficial
owner  of 1,041,667 shares of Common Stock, representing approximately 10.5%
of the  then issued  and outstanding shares  of Common Stock.   Merck  KGaA
obtained  these  shares of  Common Stock  as  the  result  of the automatic
conversion  of its Series E Preferred Stock  into  Common Stock in the IPO,
pursuant to the Stock Purchase Agreement,  dated  as of  November 25, 1992,
between the Issuer and Merck KGaA.  Other than the conversion of its Series
E Preferred Stock into Common Stock, Merck  KGaA  did  not  pay  any  other
consideration to acquire such 1,041,661 shares of Common Stock.

          In  the  course  of  the IPO, Merck KGaA acquired  an  additional
146,000 shares of Common Stock at  a  price  of  $12.00 per share directly
from  the  Issuer in  order to  maintain  an  approximate  10% ownership 
position  in  the Issuer.  The  source  of funds  for  this  purpose  was
internal working capital.

          As  of  the  closing  of the IPO and as of the date hereof, Merck
KGaA  was  the  beneficial  owner of  1,187,667  shares  of  Common  Stock,
representing approximately 9.3%  of the issued  and outstanding shares of
Common Stock.


ITEM 4.   PURPOSE OF TRANSACTION
          ----------------------

          Immediately prior  to  the IPO, Merck KGaA held 1,041,667 shares
of  Common Stock, and in the course  of  the  IPO,  Merck  KGaA acquired
an additional 146,000 shares of Common Stock, representing an aggregate of
approximately  9.3%  ownership  of the  Common Stock.  It is  the present
intention of Merck KGaA  to acquire  additional shares of Common Stock, if
necessary, perhaps on the open market, in order to maintain  an  ownership
position  of approximately  10%.  There  can be  no assurances, however,
that  Merck KGaA  will acquire  such  additional  shares  of Common Stock.
Merck KGaA intends to hold such shares of Common Stock for investment and
has no  plans  or proposals  relating  to the acquisition  of  additional
securities  of  the  Issuer  or  with  respect to material changes in the
Issuer's   business  or  corporate  structure,  including  those  matters 
enumerated  in  paragraphs  (a)  through  (j)  of Item 4 to Schedule 13D.


ITEM 5    INTEREST IN SECURITIES OF THE ISSUER
          ------------------------------------
          As  of the date of this filing, Merck KGaA owns 1,187,667  shares
of Common Stock,  representing  approximately  9.3% of the total issued and
outstanding shares of Common Stock.

                                PAGE 3 OF 5 PAGES
PAGE
<PAGE>

          Merck KGaA has the sole power to vote  or  direct  the  vote  and
disposition of such Common Stock.

          Other  than  the purchases described  in Item 4 above, no
transactions in the Common Stock  have been effected by Merck KGaA directly
or indirectly during the past 60 days.

          No  other  person has the right to receive or the power to direct
the receipt of dividends from, or the proceeds from the sale of, the Common
Stock.


                                PAGE 4 OF 5 PAGES

PAGE
<PAGE>
                             SIGNATURE

          After  reasonable  inquiry  and  to  the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.



                              Date:  March 7, 1997




                              MERCK KGaA

                              By: \s\ Klaus-Peter Brandis
			      ---------------------------	
                              Name:  Klaus-Peter Brandis
                              Title: Director

                              By: \s\ Dr. Christian Flaemig
			      ---------------------------	
                              Name:  Dr. Christian Flaemig
                              Title: Director




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