BIOSITE DIAGNOSTICS INC
S-8, 1998-07-23
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>

     As filed with the Securities and Exchange Commission on July 23, 1998.

                                                        Registration No. 333-___
- --------------------------------------------------------------------------------

                          SECURITIES AND EXCHANGE COMMISSION
                                Washington, D.C. 20549
                                       FORM S-8
                                REGISTRATION STATEMENT
                                        UNDER
                              THE SECURITIES ACT OF 1933

                           Biosite Diagnostics Incorporated
                           --------------------------------
                (Exact name of registrant as specified in its charter)


               Delaware                                33-0288606
    ---------------------------------          ---------------------------
     (State or other jurisdiction of                (I.R.S. Employer
     incorporation or organization)                 Identification No.)

         11030 Roselle Street
        San Diego, California                             92121
    ---------------------------------          ---------------------------
        (Address of Principal                          (Zip Code)
          Executive Offices)


         BIOSITE DIAGNOSTICS INCORPORATED EMPLOYEE STOCK PURCHASE PLAN
       -----------------------------------------------------------------
                            (Full title of the plan)


                                                         Copy to:
          KIM D. BLICKENSTAFF                      THOMAS E. SPARKS, JR.
    Biosite Diagnostics Incorporated           Pillsbury Madison & Sutro LLP
          11030 Roselle Street                        P.O. Box 7880
       San Diego, California 92121            San Francisco, CA  94120-7880
             (619) 455-4808                         (415) 983-1000
    ---------------------------------          ---------------------------
      (Name, address and telephone
       number, including area code,
          of agent for service)

                           CALCULATION OF REGISTRATION FEE
- --------------------------------------------------------------------------------
  Title of          Amount     Proposed Maximum      Proposed         Amount of
Securities To        To Be      Offering Price   Maximum Aggregate  Registration
Be Registered    Registered(1)    per Share(2)   Offering Price(2)       Fee
- --------------------------------------------------------------------------------
 Common Stock,   250,000 shares     $9.5625         $2,390,625          $705
par value $.01

- --------------------------------------------------------------------------------
(1)  Calculated pursuant to General Instruction E to Form S-8.

(2)  Estimated solely for the purpose of computing the registration fee pursuant
     to Rule 457, upon the average of the high and low prices as reported on the
     Nasdaq National Market on July 20, 1998.

                                 -------------------
     The Registration Statement shall become effective upon filing in accordance
with Rule 462 under the Securities Act of 1933.
- --------------------------------------------------------------------------------


<PAGE>

                       INFORMATION REQUIRED PURSUANT TO
                       GENERAL INSTRUCTION E TO FORM S-8


GENERAL INSTRUCTION E INFORMATION

     This Registration Statement is being filed to increase the number of 
securities of the same class as other securities for which a Registration 
Statement of the Registrant on Form S-8 relating to the same employee benefit 
plan is effective.

     Registrant's Form S-8 Registration Statements filed with the Securities 
and Exchange Commission on February 11, 1997, File No. 333-21537, is hereby 
incorporated by reference.

INCORPORATION OF DOCUMENTS BY REFERENCE

     The following documents filed by Registrant with the Securities and 
Exchange Commission are incorporated by reference in this Registration 
Statement:

     (1)  Registrant's Annual Report on Form 10-K (File No. 000-21873) for 
the fiscal year ended December 31, 1997, which contains, among other things, 
the financial statements of Registrant and certain supplementary 
data for the fiscal year ended December 31, 1997 together with the report 
thereon of Ernst & Young LLP, independent public accountants.

     (2)  Registrant's Quarterly Report on Form 10-Q for the quarter ended 
March 31, 1998.

     (3)  The description of Registrant's common stock contained in 
Registrant's Registration Statement on Form 8-A filed February 10, 1997.

     (4)  The description of the Preferred Stock Purchase Rights for Series A 
Participating Preferred Stock, par value $.01 per share, of the Registrant 
contained in Registrant's Registration Statement on Form 8-A filed October 
28, 1997.

     In addition, all documents subsequently filed by Registrant pursuant to 
Section 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, 
prior to the filing of a post-effective amendment which indicates that all 
securities offered have been sold or which deregisters all securities then 
remaining unsold, shall be deemed to be incorporated by reference in this 
registration statement and to be a part hereof from the date of filing of 
such documents.


<PAGE>

                                  SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the 
Registrant certifies that it has reasonable grounds to believe that it meets 
all of the requirements for filing on Form S-8, and has duly caused this 
registration statement to be signed on its behalf by the undersigned, 
thereunto duly authorized, in the City of San Diego, State of California, on 
July 22, 1998.


                                   BIOSITE DIAGNOSTICS INCORPORATED



                                   By /s/ Kim D. Blickenstaff
                                      ----------------------------------
                                          Kim D. Blickenstaff
                                   President and Chief Executive Officer

                                POWER OF ATTORNEY

     KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears 
below constitutes and appoints Kim D. Blickenstaff and Christopher J. Twomey, 
and each of them his true and lawful attorneys-in-fact and agents, each with 
full power of substitution and resubstitution, for him and in his name, place 
and stead, in any and all capacities, to sign any and all amendments, 
including post-effective amendments, to this registration statement, and to 
file the same, with exhibits thereto and other documents in connection 
therewith, with the Securities and Exchange Commission, granting unto said 
attorneys-in-fact and agents, full power and authority to do and perform each 
and every act and thing requisite and necessary to be done, as fully to all 
intents and purposes as he might or could do in person, hereby ratifying and 
confirming all that said attorneys-in-fact and agents, or his substitute or 
substitutes, may do or cause to be done by virtue hereof.

     Pursuant to the requirements of the Securities Act of 1933, this 
registration statement has been signed by the following persons in the 
capacities and on the date indicated:

          Name                     Title                         Date
          ----                     -----                         ----

/s/ Kim D. Blickenstaff       President, Chief Executive
- ---------------------------   Officer (Principal
    Kim D. Blickenstaff       Executive Officer) and        July 22, 1998
                              Director


/s/ Christopher J. Twomey     Vice President and Chief
- ---------------------------   Financial Officer
    Christopher J. Twomey     (Principal Financial          July 22, 1998
                              Officer and Accounting
                              Officer)


<PAGE>

          Name                     Title                         Date
          ----                     -----                         ----

/s/ Timothy J. Wollaeger      Chairman of the Board         July 22, 1998
- ---------------------------
    Timothy J. Wollaeger


                              Director                      July 22, 1998
- ---------------------------
    Anthony DeMaria


/s/ Frederick J. Dotzler      Director                      July 22, 1998
- ---------------------------
    Frederick J. Dotzler


/s/ Howard E. Greene, Jr.     Director                      July 22, 1998
- ---------------------------
    Howard E. Greene, Jr.


/s/ Lonnie M. Smith           Director                      July 22, 1998
- ---------------------------
    Lonnie M. Smith


/s/ Gunars E. Valkirs         Director                      July 22, 1998
- ---------------------------
    Gunars E. Valkirs, Ph.D.


<PAGE>

                                  INDEX TO EXHIBITS
                                  -----------------

<TABLE>
<CAPTION>

Exhibit                                                     Sequentially
Number    Exhibit                                           Numbered Page
- --------------------------------------------------------------------------------
<S>       <C>                                               <C>

5.1       Opinion regarding legality of                          --
          securities to be offered.

10.1      Biosite Diagnostics Incorporated
          Employee Stock Purchase Plan.

23.1      Consent of Ernst & Young LLP,                          --
          Independent Auditors.

23.2      Consent of Pillsbury Madison &
          Sutro LLP (included in Exhibit 5.1).

24.1      Power of Attorney (see page 3).
</TABLE>

<PAGE>
                                                                     EXHIBIT 5.1

                            PILLSBURY MADISON & SUTRO LLP
                                    P.O. BOX 7880
                               SAN FRANCISCO, CA 94120
                                 Tel: (650) 233-4687
                                 Fax: (650) 233-4545

                                    July 22, 1998



Biosite Diagnostics Incorporated
11030 Roselle Street
San Diego, CA 92121


Re:  Registration Statement on Form S-8


Gentlemen:

     With reference to the Registration Statement on Form S-8 to be filed by 
Biosite Diagnostics Incorporated, a Delaware corporation (the "Company"), 
with the Securities and Exchange Commission under the Securities Act of 1933, 
relating to 250,000 shares of the Company's Common Stock issuable pursuant to 
the Company's Employee Stock Purchase Plan of the Company (the "Plan"), it is 
our opinion that such shares of the Common Stock of the Company, when issued 
and sold in accordance with the Plan will be legally issued, fully paid and 
nonassessable.

     We hereby consent to the filing of this opinion with the Securities and 
Exchange Commission as Exhibit 5.1 to the Registration Statement.


                                       Very truly yours,

                                       /s/ PILLSBURY MADISON & SUTRO LLP


<PAGE>
                                                                   Exhibit 23.1

                           CONSENT OF INDEPENDENT AUDITORS


We consent to the incorporation by reference in the Registration Statement
(Form S-8) pertaining to the Employee Stock Purchase Plan of Biosite Diagnostics
Incorporated of our report dated February 6, 1998 with respect to the financial
statements of Biosite Diagnostics Incorporated included in its Annual Report
(Form 10-K) for the year ended December 31, 1997 filed with the Securities and
Exchange Commission.



                                                              ERNST & YOUNG LLP


San Diego, California
July 22, 1998



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