BIOSITE DIAGNOSTICS INC
DEF 14A, 1998-04-09
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>
                            SCHEDULE 14A INFORMATION
 
                  Proxy Statement Pursuant to Section 14(a) of
            the Securities Exchange Act of 1934 (Amendment No.    )
 
    Filed by the Registrant /X/
    Filed by a party other than the Registrant / /
 
    Check the appropriate box:
    / /  Preliminary Proxy Statement
    / /  Confidential, for Use of the Commission Only (as permitted by Rule
         14a-6(e)(2))
    /X/  Definitive Proxy Statement
    / /  Definitive Additional Materials
    / /  Soliciting Material Pursuant to Section 240.14a-11(c) or Section 
         240.14a-12

                         BIOSITE DIAGNOSTICS INCORPORATED
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)
 
- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)
 
Payment of Filing Fee (Check the appropriate box):
 
/X/  No fee required.

/ /  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) 
     and 0-11.

    (1) Title of each class of securities to which transaction applies:

        ------------------------------------------------------------------------
    (2) Aggregate number of securities to which transaction applies:

        ------------------------------------------------------------------------
    (3) Per unit price or other underlying value of transaction computed
        pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
        filing fee is calculated and state how it was determined):

        ------------------------------------------------------------------------
    (4) Proposed maximum aggregate value of transaction:

        ------------------------------------------------------------------------
    (5) Total fee paid:

        ------------------------------------------------------------------------

/ / Fee paid previously with preliminary materials.

/ / Check box if any part of the fee is offset as provided by Exchange Act Rule
    0-11(a)(2) and identify the filing for which the offsetting fee was paid
    previously. Identify the previous filing by registration statement number,
    or the Form or Schedule and the date of its filing.

    (1) Amount Previously Paid:

        ------------------------------------------------------------------------
    (2) Form, Schedule or Registration Statement No.:

        ------------------------------------------------------------------------
    (3) Filing Party:

        ------------------------------------------------------------------------
    (4) Date Filed:

        ------------------------------------------------------------------------



<PAGE>




                           Biosite Diagnostics Incorporated
                                 11030 Roselle Street
                                 San Diego, CA 92121
                                    (619) 455-4808



                                   April 16, 1998





Dear Stockholder:

     You are cordially invited to attend the Annual Meeting of Stockholders 
which will be held on May 21, 1998, at 9:00 a.m., at the Doubletree Hotel, 
11915 El Camino Real, Del Mar, California.

     The formal notice of the Annual Meeting and the Proxy Statement have 
been made a part of this invitation.

     After reading the Proxy Statement, please mark, date, sign and return, 
at an early date, the enclosed proxy in the prepaid envelope to ensure that 
your shares will be represented.  YOUR SHARES CANNOT BE VOTED UNLESS YOU 
SIGN, DATE AND RETURN THE ENCLOSED PROXY OR ATTEND THE ANNUAL MEETING IN 
PERSON.

     A copy of the Company's Annual Report to Stockholders is also enclosed.

     The Board of Directors and Management look forward to seeing you at the 
meeting.

                                   Sincerely yours,



                                   Kim D. Blickenstaff
                                   President, Chief Executive Officer,
                                   Secretary and Treasurer



<PAGE>

                           BIOSITE DIAGNOSTICS INCORPORATED

                                     ____________

                       NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                               TO BE HELD MAY 21, 1998
                                     ____________


     The Annual Meeting of Stockholders of Biosite Diagnostics Incorporated 
(the "Company") will be held at the Doubletree Hotel, 11915 El Camino Real, 
Del Mar, California, on May 21, 1998, at 9:00 a.m., for the following 
purposes:

     1.   To elect two Class I directors.

     2.   To consider and vote upon a proposal to amend and restate the
          Company's 1996 Stock Incentive Plan.

     3.   To consider and vote upon a proposal to amend and restate the
          Company's Employee Stock Purchase Plan.

     4.   To ratify the selection of Ernst & Young LLP as the Company's
          independent auditors.

     5.   To transact such other business as may properly come before the
          Annual Meeting and any adjournment of the Annual Meeting.

     The Board of Directors has fixed the close of business on April 6, 1998, 
as the record date for determining the stockholders entitled to notice of and 
to vote at the Annual Meeting and any adjournment thereof.  A complete list 
of stockholders entitled to vote will be available at the Secretary's office, 
11030 Roselle Street, San Diego, California, for ten days before the meeting.

     WHETHER YOU INTEND TO BE PRESENT AT THE ANNUAL MEETING OR NOT, WE URGE 
YOU TO MARK, DATE, SIGN AND RETURN THE ENCLOSED PROXY PROMPTLY.

                                   By order of the Board of Directors.



                                   Kim D. Blickenstaff
                                   President, Chief Executive Officer,
                                   Secretary and Treasurer
April 16, 1998


<PAGE>


                           BIOSITE DIAGNOSTICS INCORPORATED
                                     ____________

                                   PROXY STATEMENT
                                     ____________

     This Proxy Statement is furnished in connection with the solicitation by 
the Board of Directors of Biosite Diagnostics Incorporated, a Delaware 
corporation ("Biosite" or the "Company"), with principal executive offices at 
11030 Roselle Street, San Diego, California 92121, of proxies in the 
accompanying form to be used at the Annual Meeting of Stockholders to be held 
at the Doubletree Hotel, 11915 El Camino Real, Del Mar, California, on May 
21, 1998, at 9:00 a.m., and any adjournment of the Annual Meeting (the 
"Annual Meeting").  The shares represented by the proxies received in 
response to this solicitation and not revoked will be voted at the Annual 
Meeting.  A proxy may be revoked at any time before it is exercised by filing 
with the Secretary of the Company a written revocation or a duly executed 
proxy bearing a later date or by voting in person at the Annual Meeting.  On 
the matters coming before the Annual Meeting for which a choice has been 
specified by a stockholder by means of the ballot on the proxy, the shares 
will be voted accordingly.  If no choice is specified, the shares will be 
voted FOR the election of the two nominees for Class I director listed in 
this Proxy Statement and FOR approval of proposals 2, 3 and 4 described in 
the Notice of Annual Meeting and in this Proxy Statement.

     Stockholders of record at the close of business on April 6, 1998 are 
entitled to notice of and to vote at the Annual Meeting.  As of the close of 
business on such date, the Company had 12,938,308 shares of Common Stock 
outstanding and entitled to vote.  Each holder of Common Stock is entitled to 
one vote for each share held as of the record date.

     Directors are elected by a plurality vote.  The other matters submitted 
for stockholder approval at the Annual Meeting will be decided by the 
affirmative vote of a majority of shares present in person or represented by 
proxy and entitled to vote on each such matter.  Abstentions with respect to 
any matter are treated as shares present or represented and entitled to vote 
on that matter and thus have the same effect as negative votes.  If shares 
are not voted by the broker who is the record holder of the shares, or if 
shares are not voted in other circumstances in which proxy authority is 
defective or has been withheld with respect to any matter, these non-voted 
shares are not deemed to be present or represented for purposes of 
determining whether stockholder approval of that matter has been obtained.

     The expense of printing and mailing proxy materials will be borne by the 
Company.  In addition to the solicitation of proxies by mail, solicitation 
may be made by certain directors, officers and other employees of the Company 
by personal interview, telephone or telegraph.  No additional compensation 
will be paid to such persons for such solicitation.  The Company will 
reimburse brokerage firms and others for their reasonable expenses in 
forwarding solicitation materials to beneficial owners of the Company's 
Common Stock.  The Company has retained Georgeson & Co., Inc. to assist in 
the solicitation of proxies at a cost of approximately $6,000.00.

     This Proxy Statement and the accompanying form of proxy are being mailed 
to stockholders on or about April 16, 1998.

                                      IMPORTANT

     WHETHER YOU INTEND TO BE PRESENT AT THE ANNUAL MEETING OR NOT, WE URGE
     YOU TO MARK, DATE AND SIGN THE ENCLOSED PROXY AND RETURN IT AT YOUR
     EARLIEST CONVENIENCE IN THE ENCLOSED POSTAGE-PREPAID RETURN ENVELOPE. 
     THIS WILL NOT LIMIT YOUR RIGHTS TO ATTEND OR VOTE AT THE ANNUAL
     MEETING.


                                       -1-


<PAGE>

                                ELECTION OF DIRECTORS

     The Company has three classes of directors serving staggered three-year 
terms.  Class I consists of two directors.  Class II and Class III  each 
consist of three directors.  Currently, one Class III director seat is 
vacant.  Two Class I directors are to be elected at the Annual Meeting for a 
term of three years expiring at the Annual Meeting in 2001 or until each such 
director's successor shall have been elected and qualified.  The other 
directors of the Company will continue in office for their existing terms, 
which expire in 1999 and 2000 for Class II and Class III directors, 
respectively.

COMPOSITION OF BOARD OF DIRECTORS

     Unless authority to vote for directors is withheld, it is intended that 
the shares represented by the enclosed proxy will be voted for the election 
of Lonnie M. Smith and Timothy J. Wollaeger as Class I directors.  The 
nominees have been nominated as Class I directors by the Nominating Committee 
of the Company's Board of Directors.  In the event any of such nominees 
becomes unable or unwilling to accept nomination or election, the shares 
represented by the enclosed proxy will be voted for the election of the 
balance of those named and such other nominees as the Board of Directors may 
select.  The Board of Directors has no reason to believe that any such 
nominee will be unable or unwilling to serve.  There are no family 
relationships among any of the directors or executive officers of the Company.

     Set forth below is information regarding the two nominees for Class I 
director and the continuing directors of Class II and Class III, including 
information furnished by them as to their principal occupations at present 
and for the past five years, certain directorships held by each, their ages 
as of March 31, 1998 and the year in which each became a director of the 
Company.

Name                                                                        Age
- ----                                                                        ---

CLASS I

Lonnie M. Smith...........................................................   53

     Mr. Smith joined the Board of Directors in October of 1997.  Mr. Smith 
is Chief Executive Officer of Intuitive Surgical Inc., a surgical device 
company. From 1982 to February 1997, he served as Senior Executive Vice 
President in charge of healthcare for Hillenbrand Industries, Inc. 
("Hillenbrand"), a diversified public holding company.  Mr. Smith was a 
director of Hillenbrand from 1981 to February 1997.  He had been employed by 
Hillenbrand or its subsidiaries in various offices since 1976.  Mr. Smith 
received a B.S. in Electrical Engineering from Utah State University and an 
M.B.A. from Harvard Business School.

Timothy J. Wollaeger........................................................  54

     Mr. Wollaeger has served as Chairman of the Board of Directors since the 
Company's inception.  He is the general partner of Kingsbury Associates, 
L.P., a venture capital firm he founded in December 1993.  From May 1990 
until December 1993, he was Senior Vice President and a director of Columbia 
Hospital Corporation (now Columbia/HCA Healthcare Corporation).  From October 
1986 until July 1993, he was a general partner of the general partner of 
Biovest Partners, a California Limited Partnership ("Biovest"), a seed 
venture capital firm.  He is a director of Amylin Pharmaceuticals, Inc. 
("Amylin") and Aurora Biosciences, Inc., and a founder and director of 
several privately held medical products companies.  Mr. Wollaeger received a 
B.A. in Economics from Yale University and an M.B.A. from Stanford University.


                                       -2-


<PAGE>

CLASS II

Thomas H. Adams.............................................................  55

     Dr. Adams joined the Board of Directors in September 1988.  He has been 
a consultant to Nanogen, Inc., a biotechnology firm developing microchips for 
the analysis of molecular information, since June 1997.  Dr. Adams was a 
founder of Genta Incorporated ("Genta"), a biotechnology company, and was 
Chairman of the Board and Chief Executive Officer of Genta from February 1989 
to April 1997.  He previously served as Chairman of the Board and Chief 
Executive Officer of Gen-Probe Incorporated ("Gen-Probe"), which he 
co-founded in 1984.  Prior to joining Gen-Probe, he held the positions of 
Senior Vice President of Research & Development and Chief Technical Officer 
at Hybritech Incorporated ("Hybritech"). He had previously held senior 
scientific management positions with Technicon Instruments Corp., the Hyland 
Laboratories Division of Baxter Travenol, and DuPont.  Dr. Adams is a 
director of Life Technologies, Inc., La Jolla Pharmaceutical Company and a 
private biotechnology company.  Dr. Adams received his Ph.D. in Biochemistry 
from the University of California at Riverside.

Frederick J. Dotzler........................................................  52

     Mr. Dotzler joined the Board of Directors in July 1989.  Mr. Dotzler is 
General Partner of Medicus Venture Partners ("Medicus"), a venture capital 
firm he founded in 1989.  Prior to founding Medicus, Mr. Dotzler was a 
general partner of Crosspoint Venture Partners.  Previously he held 
management positions with Millipore Corporation, G.D. Searle & Co., and IBM.  
He is a director of several privately held companies.  Mr. Dotzler received a 
B.S. in Industrial Engineering from Iowa State University, an M.B.A. from the 
University of Chicago, and a degree in Economics from the University of 
Louvain, Belgium.

Howard E. Greene, Jr. ......................................................  55

     Mr. Greene joined the Board of Directors in June 1989.  Mr. Greene is a 
founder and Chairman of the Board of Amylin, a biotechnology company in late 
stage development of a drug candidate for diabetes, and he was Chief 
Executive Officer of Amylin from inception in September 1987 to July 1996.  
From October 1986 until July 1993, Mr. Greene was a general partner of the 
general partner of Biovest.  From March 1979 to March 1986, he was Chief 
Executive Officer of Hybritech, and he was co-inventor of Hybritech's 
monoclonal antibody assay technology.  Prior to joining Hybritech, he was an 
executive with the medical diagnostics division of Baxter Healthcare 
Corporation from 1974 to 1979 and a consultant with McKinsey & Company from 
1967 to 1974.  He is Chairman of the Board of Cytel Corporation, a director 
of Allergan, Inc., Neurex Corporation and The International Biotechnology 
Trust plc, a foreign biotechnology investment company.  Mr. Greene received 
an M.B.A. from Harvard University.

CLASS III

Kim D. Blickenstaff.........................................................  45

     Mr. Blickenstaff, a founder of the Company, has been a director and 
President, Chief Executive Officer, Treasurer, and Secretary since April 
1988. Mr. Blickenstaff also is a director of Micro Therapeutics Incorporated 
and Medi Spectra Inc.  Prior to joining Biosite, he held various positions in 
finance, operations, research management, sales management, strategic 
planning, and marketing with Baxter Travenol, National Health Laboratories, 
and Hybritech. Mr. Blickenstaff holds an M.B.A. from the Graduate School of 
Business, Loyola University, Chicago.


                                       -3-


<PAGE>

Gunars E. Valkirs, Ph.D. ...................................................  46
     
     Dr. Valkirs, a founder of Biosite and a co-inventor of certain of its 
proprietary technology, has been a director and Vice President, Research and 
Development and Chief Technical Officer since 1988.  Prior to forming 
Biosite, he was a Scientific Investigator with the Diagnostics Research & 
Development Group at Hybritech, where he was the primary inventor of 
Hybritech's patented ICON technology.  Dr. Valkirs holds a Ph.D. in Physics 
from the University of California at San Diego.

     The Board of Directors held five meetings during the 1997 fiscal year.  
All Directors then in office attended at least 75% of the aggregate number of 
meetings of the Board and of the Committees on which such Directors served.

     The Board of Directors has appointed a Compensation Committee, a 
Nominating Committee, an Employee Stock Option Committee, and an Audit 
Committee.

     The current members of the Compensation Committee are Frederick J. 
Dotzler and Timothy J. Wollaeger.  The Compensation Committee held one 
meeting during the 1997 fiscal year.  The Compensation Committee's functions 
are to determine and supervise compensation to be paid to officers and 
directors of the Company and to assist in the administration of, and grant 
options under, the 1996 Stock Incentive Plan, to assist in the administration 
of the Amended and Restated 1989 Stock Plan and the Employee Stock Purchase 
Plan and to assist in the implementation of, and provide recommendations with 
respect to, general and specific compensation policies and practices of the 
Company.  See "Report to Stockholders on Executive Compensation."

     The current members of the Nominating Committee are Kim D. Blickenstaff 
and Timothy J. Wollaeger.  The Nominating Committee held one meeting during 
the 1997 fiscal year.  The Nominating Committee's function is to select and 
nominate individuals to fill vacancies in the Company's Board of Directors.  
The Nominating Committee will not consider nominees recommended by 
securityholders.

     The sole member of the Employee Stock Option Committee is Kim D. 
Blickenstaff.  The Employee Stock Option Committee held twenty-two meetings 
during 1997.  The Employee Stock Option Committee's functions are to assist 
in the administration of, and grant options under, the 1996 Stock Incentive 
Plan with respect to employees who are not officers or directors of the 
Company.

     The current members of the Audit Committee are Frederick J. Dotzler and 
Timothy J. Wollaeger.  The Audit Committee held two meetings during the 1997 
fiscal year.  The Audit Committee's functions are to review the scope of the 
annual report, monitor the independent auditor's relationship with the 
Company, advise and assist the Board of Directors in evaluating the auditor's 
report, supervise the Company's financial and accounting organization and 
financial reporting and nominate for stockholder approval at the annual 
meeting, with the approval of the Board of Directors, a firm of certified 
public accountants whose duty it is to audit the financial records of the 
Company for the fiscal year for which it is appointed.

     THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE CLASS I DIRECTOR 
NOMINEES LISTED ABOVE.


                                       -4-


<PAGE>

             STOCK OWNERSHIP OF MANAGEMENT AND CERTAIN BENEFICIAL OWNERS

     The following table sets forth information as of March 31, 1998, 
regarding beneficial ownership of the Company's Common Stock by (i) each 
director and nominee for director, (ii) each of the Company's officers named 
in the Summary Compensation Table set forth herein, (iii) all directors and 
executive officers of the Company as a group, and (iv) each person who is 
known by the Company to beneficially own more than 5% of the Company's Common 
Stock.  Except as otherwise indicated and subject to applicable community 
property laws, each person has sole investment and voting power with respect 
to the shares shown. Ownership information is based upon information 
furnished by the respective individuals or entities, as the case may be.

<TABLE>
<CAPTION>
                                                 SHARES             PERCENT
                                              BENEFICIALLY       BENEFICIALLY
                                                  OWNED              OWNED 
                                              ------------       ------------
<S>                                            <C>                   <C>
Medicus Venture Partners (1)(2)............    1,663,344             12.9%
 2882 Sand Hill Road
 Suite 116
 Menlo Park, CA  94025

Wellington Management Company, L.L.P.(3)...    1,222,000               9.5
 75 State Street
 Boston, MA 02109

Merck KGaA.................................     1,187,667              9.2
 Frankfurter Strasse 250
 D-64293 Darmstadt
 Federal Republic of Germany

Euclid Partners III, L.P. .................    1,005,869               7.8
 50 Rockefeller Plaza
 New York, NY  10020

Timothy J. Wollaeger (2)(4)................       707,800              5.5
 c/o Kingsbury Partners L.P.
 3655 Nobel Drive, Suite 490
 San Diego, CA  92122

Frederick J. Dotzler (1)(2)................     1,669,334             13.0
Howard E. Greene, Jr. (2)(5)...............       298,712              2.3
Thomas H. Adams, Ph.D. (2).................        54,618               *
Lonnie Smith...............................         1,510               *
Kim D. Blickenstaff (2)....................       331,202              2.6
Gunars E. Valkirs (2)(6)...................       313,724              2.4
Kenneth F. Buechler (2)....................       309,494              2.4
Charles W. Patrick (2).....................        88,835               *
Thomas M. Watlington(2)....................        39,041               *
All directors and executive officers as a 
group (12 persons)(2)(7)...................     3,998,373             30.0%

</TABLE>
__________
*  Less than 1%


                                       -5-


<PAGE>

(1)  Includes (i) 704,225 shares held by Medicus Venture Partners 1989, (ii)
     520,833 shares held by Medicus Venture Partners 1990, (iii) 333,334 shares
     held by Medicus Venture Partners 1991 and (iv) 104,167 shares held by
     Medicus Venture Partners 1992 (collectively, the "Medicus Entities").  A
     limited partnership affiliated with The Hillman Company and a limited
     partnership with general partners Frederick J. Dotzler and John Reher are
     each general partners of each of the Medicus Entities, and therefore may be
     deemed to be the beneficial owner of these shares because they share the
     power to vote and dispose of these shares.  The Hillman Company is
     controlled by Henry L. Hillman, Elsie Hilliard Hillman and C.G.
     Grefenstette, trustees (the "HLH Trustees") of the Henry L. Hillman Trust
     U/A dated November 18, 1985 (the "HLH Trust"), which three trustees share
     the power to vote and dispose of shares representing a majority of the
     voting shares of The Hillman Company.  Does not include 143,409 shares held
     directly by the HLH Trust or 134,423 shares held directly by Wilmington
     Interstate Corporation, an indirect, wholly-owned subsidiary of The Hillman
     Company.  Also does not include an aggregate of 20,164 shares held by four
     irrevocable trusts for the benefit of members of the Hillman family (the
     "Family Trusts"), as to which shares the HLH Trustees (other than Mr.
     Grefenstette) disclaim beneficial ownership.  C.G. Grefenstette and Thomas
     G. Bigley are trustees of the Family Trusts and share voting and
     dispositive power over the assets of the Family Trusts.

(2)  Includes shares which may be acquired pursuant to the exercise of options
     within 60 days of March 31, 1998 as follows: Medicus Venture Partners 1997,
     785, Mr. Wollaeger, 785, Mr. Greene, 785, Dr. Adams, 785, Mr. Smith 1,510,
     Mr. Blickenstaff, 104,292, Dr. Valkirs, 77,698, Dr. Buechler, 90,598, Mr.
     Patrick, 43,520, Mr. Watlington, 38,628 and all directors and executive
     officers as a group (12 persons), 435,008.

(3)  Based on its Schedule 13G dated February 10, 1998, wherein Wellington
     Management Company, L.L.P. ("WMC") reported the beneficial ownership of
     1,222,000 shares of Company Common Stock.  The Schedule 13G states that
     such shares are owned by a variety of clients as to whom WMC is an
     investment advisor.  WMC reports that it has shared power to vote or to
     direct the vote of 652,000 of such shares and shared power to dispose or to
     direct the disposal of all 1,222,000 shares, and does not have sole voting
     or dispositive power with respect to any such shares.

(4)  Includes 635,417 shares held by Kingsbury Capital Partners I, L.P. Mr.
     Wollaeger is a general partner of the general partner of Kingsbury Capital
     Partners I, L.P., and as such, may be deemed to share voting and investment
     power with respect to the shares held by the partnership. Mr. Wollaeger
     disclaims beneficial ownership of such shares, except to the extent of his
     pecuniary interest in such partnership.  Includes 6,722 shares held in a
     trust for the benefit of Mr. Wollaeger's family as to which Mr. Wollaeger
     has shared voting and investment power.

(5)  Includes 297,927 shares held in a trust for the benefit of Mr. Greene's
     family as to which Mr. Greene has shared voting and investment power.

(6)  Includes 235,834 shares held of record by the Valkirs Family Trust.

(7)  Includes shares held by entities referenced in footnotes 1, 4, 5 and 6
     which are affiliated with certain directors.


                                       -6-


<PAGE>

                   COMPENSATION OF EXECUTIVE OFFICERS AND DIRECTORS

     Information is set forth below concerning the annual and long-term
compensation for services in all capacities to the Company for the fiscal years
ended December 31, 1995, 1996 and 1997 of those persons who were at December 31,
1997 (i) the Chief Executive Officer and (ii) the other four most highly
compensated executive officers of the Company whose salary and bonus exceeded
$100,000 (the "Named Executive Officers").

                             SUMMARY COMPENSATION TABLE

<TABLE>
<CAPTION>


                                                                                                          LONG-TERM
                                                           ANNUAL COMPENSATION                          COMPENSATION
                                                                                                           AWARDS
                                                                                                        ------------
                                                                                                         SECURITIES
              NAME AND                                                               OTHER ANNUAL        UNDERLYING
         PRINCIPAL POSITION                    YEAR     SALARY ($)(1)  BONUS ($)  COMPENSATION ($)(2)    OPTIONS (#)
         ------------------                    ----     -------------  ---------  -------------------   -------------
<S>                                            <C>        <C>           <C>             <C>              <C>
Kim D. Blickenstaff.......................     1997        $205,682     $112,159         $ 1,567             25,000
  President and Chief Executive Officer        1996         189,242       92,991             980            100,000(3)
                                               1995         169,633       78,462             900             40,000

Thomas M. Watlington......................     1997         202,392       32,239          69,214(4)           5,000
  Senior Vice President                        1996            0(5)            0               0            100,000

Charles W. Patrick........................     1997         165,697       34,670             574              7,500
     Vice President, Sales and Marketing       1996         157,409       29,086             540             50,000(3)
                                               1995         151,000       27,002          59,290(6)           5,000

Gunars E. Valkirs........................      1997         162,833       58,414           1,287             12,500
 Vice President, Research and Development      1996         151,545       60,450             844             50,000(3)
                                               1995         139,208       36,244             793             25,000

Kenneth F. Buechler.....................       1997         152,833       63,414             819             12,500
  Vice President, Research                     1996         140,466       60,450             768             50,000(3)
                                               1995         125,823       36,244             709             25,000
</TABLE>
_________________

(1)  Includes amounts deferred by each individual under the Company's 401(k)
     Plan.

(2)  Except where noted amounts represent payments on behalf of each individual
     for group term life insurance and separate term life insurance.

(3)  On September 6, 1996, one half of these options were canceled.

(4)  Amount also includes $41,468 of relocation costs and $27,134 related to
     income tax associated with the relocation costs.

(5)  Mr. Watlington joined the Company in December 1996 and was not compensated
     for his services until 1997.

(6)  Amount also includes forgiveness of a $36,000 relocation loan made in
     August 1990 which was forgiven in August 1995 and $22,776 related to income
     taxes associated with the forgiveness of the loan.


                                      -7-


<PAGE>


STOCK OPTIONS

     The following tables summarize option grants and exercises during fiscal 
1997 to or by the Chief Executive Officer and the Named Executive Officers, 
and the value of the options held by such persons at the end of fiscal 1997.  
The Company has not granted any Stock Appreciation Rights.

                             OPTION GRANTS IN FISCAL 1997
<TABLE>
<CAPTION>
                                                                                                         POTENTIAL REALIZABLE
                                                                                                                 VALUE
                                                                                                        AT ASSUMED ANNUAL RATE
                                         NUMBER           % OF                                               OF STOCK PRICE
                                      OF SECURITIES    TOTAL OPTIONS                                         APPRECIATION
                                       UNDERLYING        GRANTED TO    EXERCISE OR                         FOR OPTION TERM(4)
                                         OPTIONS        EMPLOYEES IN    BASE PRICE     EXPIRATION       -------------------------
               NAME                   GRANTED(#)(1)    FISCAL YEAR(2)   ($/Sh)(3)         DATE            5% ($)         10% ($)
             -------                 --------------    --------------   ---------      ----------         ------        ---------
<S>                                  <C>               <C>              <C>            <C>                <C>           <C>
Kim D. Blickenstaff................       25,000            6.74          12.38          2/27/07          194,643        493,263
Thomas M. Watlington...............        5,000            1.35          12.38          2/27/07           38,929         98,653
Charles W. Patrick.................        7,500            2.02          12.38          2/27/07           58,393        147,979
Gunars E. Valkirs..................       12,500            3.37          12.38          2/27/07           97,321        246,632
Kenneth F. Buechler................       12,500            3.37          12.38          2/27/07           97,321        246,632
</TABLE>
________________

(1)  These options vest daily over a four-year period commencing on the date of
     grant, except that no options are exercisable for the first six months
     after the date of grant.  The number of shares which have vested under an
     option grant is determined by ascertaining the number of days subsequent to
     the date of the option grant, multiplying that number of days by the number
     of shares subject to the option grant, and in turn multiplying that product
     by 0.000684931 (one divided by the product of 365 days and four years).

(2)  The Company granted to employees options to acquire 370,600 shares of the
     Company's Common Stock in 1997.

(3)  The exercise price of each option was equal to 100% of the fair market
     value of the Common Stock on the date of grant, as determined by the
     Compensation Committee of the Board of Directors.

(4)  The potential realizable value of each grant of options has been
     calculated, pursuant to the regulations promulgated by the Securities and
     Exchange Commission, assuming that the market price of the Common Stock
     appreciates in value from the date of grant to the end of the option term
     at the annualized rates of 5% and 10% respectively.  These values do not
     represent the Company's estimate or projection of future Common Stock
     value.  There can be no assurance that any of the value reflected in the
     table will be achieved.


                                        -8-

<PAGE>

           AGGREGATED OPTION EXERCISES IN FISCAL 1997 AND VALUE OF OPTIONS
                                AT END OF FISCAL 1997
<TABLE>
<CAPTION>
                                                                            NUMBER OF SECURITIES       VALUE OF UNEXERCISED
                                                                           UNDERLYING UNEXERCISED           IN-THE-MONEY
                                                                             OPTIONS AT END OF           OPTIONS AT END OF
                                                                               FISCAL 1997 (#)            FISCAL 1997($)(1)
                                   SHARES ACQUIRED          VALUE         -------------------------   -------------------------
NAME                               ON EXERCISE (#)        REALIZED($)     EXERCISABLE/UNEXERCISABLE   EXERCISABLE/UNEXERCISABLE
- ----                               ---------------      -------------     -------------------------   -------------------------
<S>                                <C>                  <C>               <C>                         <C>
Kim D. Blickenstaff...........                0                  0              92,494/65,706               557,970/186,646
Thomas M. Watlington..........                0                  0              27,854/77,146                90,577/247,423
Charles W. Patrick............           16,000            137,200              39,675/24,225                262,985/65,787
Gunars E. Valkirs.............                0                  0              71,287/34,413               469,414/102,502
Kenneth F. Buechler...........            1,100              9,438              83,810/34,790               557,103/105,095
</TABLE>
________________

(1)  Calculated on the basis of the fair market value of the underlying
     securities at December 31, 1997 ($8.875) minus the exercise price.


COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     The members of the Company's Compensation Committee during 1997 were Mr. 
Dotzler and Mr. Wollaeger.  There were no interlocks or other relationships 
among the Company's executive officers and directors that are required to be 
disclosed under applicable executive compensation disclosure regulations.

COMPENSATION OF DIRECTORS

     Outside directors of the Company receive $750 to $1,000 for each Board 
Meeting attended and $250 to $500 for each committee meeting attended. 
Directors are also reimbursed for their expenses for each meeting attended. 
Directors are eligible to participate in the 1996 Stock Plan.  In February 
1997, the Board of Directors approved an annual grant to each non-employee 
director of 2,500 non-qualified stock options under the 1996 Stock Plan.  
Additionally, in October 1997, the Board of Directors approved a grant of 
10,000 non-qualified stock options under the 1996 Stock Plan to Lonnie Smith. 
These options vest daily over a four-year period commencing on the date of 
grant, and vested options are exercisable commencing on the date of the grant.

     Under the 1996 Stock Plan, directors may elect to defer their fees until 
they terminate service with the Board of Directors.  The deferred fees shall 
be deemed invested in Company Common Stock and will be paid in cash in a lump 
sum or installments as determined by the Company.  Under this arrangement,
Howard Greene and Thomas Adams each have deferred fees equivalent to 112.68
stock units.

PENSION AND LONG-TERM INCENTIVE PLANS

     The Company has no pension or long-term incentive plans.

                   REPORT TO STOCKHOLDERS ON EXECUTIVE COMPENSATION

     This report on executive compensation is provided by the Compensation 
Committee of the Board of Directors, which is comprised of two non-employee 
directors (the "Compensation Committee" or the "Committee"), to assist 
stockholders in understanding the objectives and procedures used in 
establishing the compensation of the Company's executive officers and 
describes the bases on which 1997 compensation determinations were made by 
the Committee.  In making its determinations, the Compensation Committee 
relied in part upon independent surveys and public disclosures of the 
compensation of management of companies in the biotechnology industry.


                                       -9-


<PAGE>

     It is the Company's policy generally to qualify compensation paid to 
executive officers for deductibility under section 162(m) of the Internal 
Revenue Code.  Section 162(m) generally prohibits the Company from deducting 
the compensation of executive officers that exceeds $1,000,000 unless that 
compensation is based on the satisfaction of objective performance goals.  
The Company's 1996 Stock Incentive Plan is structured to qualify awards under 
such plans as performance-based compensation and to maximize the tax 
deductibility of such awards.  However, the Company reserves the discretion 
to pay compensation to its executive officers that may not be deductible.

COMPENSATION PHILOSOPHY AND OBJECTIVES

     The Compensation Committee believes that compensation of the Company's 
executive officers should:

     -    encourage creation of stockholder value and achievement of strategic
          corporate objectives;
     -    integrate compensation with the Company's annual and long-term
          corporate objectives and strategy, and focus executive behavior on the
          fulfillment of those objectives;
     -    provide a competitive total compensation package that enables the
          Company to attract and retain, on a long-term basis, high caliber
          personnel;
     -    provide total compensation opportunity that is competitive with
          companies in the biotechnology industry, taking into account relative
          company size, performance and geographic location as well as
          individual responsibilities and performance; and
     -    align the interests of management and stockholders and enhance
          stockholder value by providing management with longer term incentives
          through equity ownership.

KEY ELEMENTS OF EXECUTIVE COMPENSATION

     Executive officer compensation is based primarily on the Company's 
achievement of certain business objectives including profit levels and return 
on equity, the achievement of product development milestones, the initiation 
and continuation of corporate collaborations, and the issuance of patents 
relating to the Company's proprietary technology and the completion of 
financings, as well as individual contribution and achievement of individual 
business objectives by each of such officers.  Corporate and individual 
objectives are established at the beginning of each fiscal year.  Performance 
by the Company and executive officers is measured by reviewing and 
determining if the corporate and individual objectives have been 
accomplished.  Currently, the Company's compensation structure for executive 
officers includes a combination of base salary, cash bonuses and stock 
options.

     BASE SALARY.  Salary levels are largely determined through comparisons 
with companies of similar headcount and market capitalizations or complexity 
in the medical device and biotechnology industries.  Actual salaries are 
based on individual performance contributions within a competitive salary 
range for each position that is established through job evaluation of 
responsibilities and market comparisons.  The Compensation Committee, on the 
basis of its knowledge of executive compensation in the industry, believes 
that the Company's salary levels for the executive officers are at a level 
that the Committee, at the time such salary determinations were made, 
considered to be reasonable and necessary given the Company's financial 
resources and the stage of its development.  In February of 1997, the 
Compensation Committee set annual salaries for 1997.  The Compensation 
Committee reviews salaries on an annual basis, with the annual review for 
1998 having occurred in January of 1998.  At an annual review, the 
Compensation Committee may increase each executive officer's salary based on 
the individual's contributions and responsibilities over the prior 12 months 
and expectations for the next 12 months.

     BONUS.  The Committee may award bonuses at the end of the fiscal year 
based on the Company's achievements and the individual's contributions to 
those achievements, if it deems such an award to be appropriate.  Based on 
the Company's achievement of a number of key objectives in 1997 that were 
important for the continued growth and development of the Company, including 
raising additional financial resources for the Company through the initial 
public offering of the Company's Common Stock, research and development 


                                       -10-


<PAGE>

milestones, expansion of the Novartis collaboration, and financial 
performance, the Committee decided to award cash bonuses for 1997 to certain 
officers and key employees.

     STOCK OPTIONS.  Long-term incentives are provided by means of periodic 
grants of stock options.  The Company's 1996 Stock Incentive Plan is 
administered by the Compensation Committee.  The Committee believes that by 
granting executive officers an opportunity to obtain and increase their 
personal ownership of Company stock, the best interests of stockholders and 
executives will be more closely integrated.  The options have exercise prices 
equal to fair market value on the date of grant, vest over a four-year 
period, and expire ten years from the date of grant.  Vesting ceases should 
the executive leave the Company's employ.  These vesting provisions of the 
option plan serve to retain qualified employees, providing continuing 
benefits to the Company beyond those achieved in the year of grant.  
Therefore, executive officers, as well as all employees who work at least 20 
hours per week, independent contractors and advisors who perform services for 
the Company, are eligible to receive stock options periodically at the 
discretion of the Committee.  Consideration is given to the executive 
officer's performance against the accomplishment of corporate objectives, to 
comparisons with other medical device and biotechnology companies at similar 
stages of development as determined by independent surveys and the 
Committee's knowledge of industry practice, to the number of options 
previously granted to each executive officer and to the extent of vesting of 
options and/or restricted stock previously awarded to each executive officer.

CHIEF EXECUTIVE OFFICER COMPENSATION

     The salary paid to Kim D. Blickenstaff, the Company's President and 
Chief Executive Officer, was $205,682 in 1997.  In establishing Mr. 
Blickenstaff's salary base, the Committee recognized Mr. Blickenstaff's 
efforts in advancing the development and growth of the Company and the 
corporate objectives achieved in 1997.  Specifically, corporate objectives 
achieved included the initial public offering, research and development 
milestones, corporate collaborations and financial performance.  The 
Committees determined that these accomplishments were critical to the 
Company's future growth and enhancement of stockholder value and, 
accordingly, determined to compensate Mr. Blickenstaff for his efforts on 
behalf of the Company.  In addition, the Compensation Committee reviewed the 
results of a survey of executive salaries of the officers of similar 
companies in the medical device and biotechnology industries.  The Committee 
also took into consideration certain traditional performance standards, such 
as profit levels and return on equity, in the evaluation of Mr. Blickenstaff's
performance.

     Mr. Blickenstaff is a member of the Board of Directors, but did not 
participate in matters involving the evaluation of his own performance or the 
setting of his own compensation.

     The foregoing report has been furnished by the Compensation Committee of 
the Board of Directors and shall not be deemed incorporated by reference by 
any general statement incorporating by reference this proxy statement into 
any filing under the Securities Act of 1933 or under the Securities Exchange 
Act of 1934, except to the extent the Company specifically incorporates this 
report by reference and shall not otherwise be deemed filed under such Acts.

               Timothy J. Wollaeger, Chairman
               Frederick J. Dotzler


                                        -11-

<PAGE>

                            STOCK PRICE PERFORMANCE GRAPH

     The following graph illustrates a comparison of the cumulative total 
stockholder return (change in stock price plus reinvested dividends) of the 
Company's Common Stock with the Center for Research in Securities Prices 
("CRSP") Total Return Index for The Nasdaq Stock Market (U.S. and Foreign) 
(the "Nasdaq Composite Index") and the S&P Medical Products & Supplies Index 
(the "S&P Medical Products Index") since February 12, 1997 (the effective 
date of the Company's initial public offering).  The comparisons in the graph 
are required by the Securities and Exchange Commission and are not intended 
to forecast or be indicative of possible future performance of the Company's 
Common Stock.





                              [GRAPH]

<TABLE>
<CAPTION>
                      02/12/97  03/31/97  06/30/97  09/30/97  12/31/97
                      --------  --------  --------  --------  --------
<S>                   <C>       <C>       <C>       <C>       <C>
Biosite               $ 100.00    $81.25    $78.12    $72.92    $73.96
Nasdaq Composite        100.00     90.01    106.37    124.51    116.03
S&P Medical Products    100.00     91.52    109.63    113.26    114.73
</TABLE>



     Assumes a $100 investment on February 12, 1997 in each of the Company's
Common Stock, the securities comprising the Nasdaq Composite Index, and the
securities comprising the S&P Medical Products Index.


                                       -12-


<PAGE>

                    CERTAIN RELATIONSHIP AND RELATED TRANSACTIONS

     In June 1994, the Company entered into two agreements with Merck, a 
collaborative development agreement and a supply and distribution agreement, 
in connection with the Company's development of Triage Cardiac.  Merck 
beneficially owns more than 5% of the Company's Common Stock and currently 
distributes the Triage DOA in certain countries in Europe, Latin America, the 
Middle East, Asia and Africa.  In December 1997, Merck agreed to terminate 
the Triage Cardiac agreements, effective January 31, 1998 in return for the 
forgiveness of approximately $1,300,000 owed to the Company by Merck related 
to the development of the Triage Cardiac products and a cash payment of 
$2,100,000.  Merck also agreed to terminate the distributorship agreement for 
the Triage DOA product line effective December 31, 1998.

     In April 1997, the Company loaned Mr. Blickenstaff, a director and 
President, Chief Executive Officer, Secretary and Treasurer of the Company, 
$150,000.  The promissory note bears interest at 6.39% and is due on April 2, 
2002.  The note is secured by 50,000 shares of Company Common Stock owned by 
Mr. Blickenstaff.  In March 1997, the Company loaned Mr. Watlington, Senior 
Vice President of the Company, $100,000. The mortgage note bore no interest
and was repaid in full in June, 1997.

     The Company believes that the foregoing transactions were in its best 
interests.  As a matter of policy these transactions were, and all future 
transactions between the Company and its officers, directors or principal 
shareholders will be, approved by a majority of the independent and 
disinterested members of the Board of Directors, on terms no less favorable 
to the Company than could be obtained from unaffiliated third parties and in 
connection with bona fide business purposes of the Company.

                                      PROPOSAL 2
                   APPROVAL OF THE AMENDMENT AND RESTATEMENT OF THE
                BIOSITE DIAGNOSTICS INCORPORATED STOCK INCENTIVE PLAN

     The 1996 Stock Incentive Plan (the "1996 Plan") was adopted by the Board 
of Directors on December 5, 1996, to be effective December 1, 1996, and was 
approved by the stockholders in December 1996.  The 1996 Plan replaced the 
Company's 1989 Stock Plan.  Awards are currently made under the 1996 Plan. 
Awards previously made under the 1989 Stock Plan, however, continue to be 
administered in accordance with the 1989 Stock Plan.  On February 27, 1998, 
the Board of Directors amended and restated the plan (as amended and 
restated, the "Stock Incentive Plan") to reserve an additional 500,000 shares 
for issuance under the Stock Incentive Plan, subject to the approval of the 
Company's stockholders at the Annual Meeting.

     The full text of the Stock Incentive Plan, substantially in the form in 
which it will take effect if approved by the Company's stockholders, is set 
forth in Exhibit A to this Proxy Statement. The following summary of the 
principal features of the Stock Incentive Plan is subject to, and qualified 
in its entirety by, Exhibit A.

DESCRIPTION OF THE STOCK INCENTIVE PLAN

     PURPOSE

     The purpose of the Stock Incentive Plan is to promote the interests of 
the Company and its stockholders by encouraging key individuals to acquire 
stock or to increase their proprietary interest in the Company. By providing 
the opportunity to acquire stock or receive other incentives, the Company 
seeks to attract and retain those key employees upon whose judgment, 
initiative and leadership the success of the Company largely depends.  The 
Company's Board of Directors believes that the Stock Incentive Plan will 
constitute an important means of compensating key employees.


                                       -13-


<PAGE>


     SHARES SUBJECT TO THE STOCK INCENTIVE PLAN

     The total number of restricted shares, stock units, options and SARs 
available for grant under the Stock Incentive Plan is 1,400,000 (which number 
includes the 500,000 share increase that stockholders are being asked to 
approve), increased by the amount of all remaining shares available for grant 
under the 1989 Stock Plan as of December 1, 1996 and subject to anti-dilution 
adjustments. If any restricted shares, stock units, options or SARs are 
forfeited, or if options or SARs terminate for any other reason prior to 
exercise (other than the exercise of a related SAR or option, and including 
any forfeiture or termination under the 1989 Stock Plan), then they again 
become available for awards under the Stock Incentive Plan.

     OUTSTANDING GRANTS

     As of March 31, 1998, an aggregate of 225 stock units and 1,525,340 
options were outstanding under the 1989 Stock Plan and the 1996 Plan 
(collectively, the "Plan").  As of March 31, 1998, approximately 220 
employees, 7 directors and 3 consultants or advisors were eligible to 
participate in the Plan.  On March 31, 1998, the closing price of the 
Company's Common Stock on the Nasdaq National Market was $16.3125 per share.  
Of the options granted, 522,566 have been exercised.  As of March 31, 1998, 
an aggregate of 1,924,958 shares are authorized, but unissued under the Plan.

     As of March 31, 1998, the following persons or groups had in total 
received restricted stock, stock units and/or options under the Plan: (i) the 
Chief Executive Officer and the other remaining officers named in the Summary 
Compensation Table:  Mr. Blickenstaff 228,200 shares, Mr. Watlington 105,000 
shares, Mr. Patrick 129,900 shares, Dr. Valkirs 150,700 shares and Dr. 
Buechler 150,700 shares; (ii) all current executive officers of the Company 
as a group: 862,300 shares; (iii) all current directors who are not executive 
officers as a group: 17,500 shares; (iv) the nominees for Class I director: 
Mr. Smith 10,000 shares and Mr. Wollaeger 2,500 shares; (v) each associate of 
any of such current directors, executive officers or nominees: 2,500 shares; 
(vi) each person who has received five percent of options granted other than 
those included above: 0; and (vii) all employees and consultants of the 
Company: 2,719,326 shares.

     ADMINISTRATION

     The Stock Incentive Plan is administered by the Board of Directors or 
its delegate. The Board, or its delegate, selects the employees of the 
Company who will receive awards, determines the size of any award and 
establishes any vesting or other conditions. Employees, directors, 
consultants and advisors of the Company (or any subsidiary of the Company) 
are eligible to participate in the Stock Incentive Plan, although incentive 
stock options may be granted only to employees. No individual may receive 
options or stock appreciation rights ("SARs") covering more than 250,000 
shares in any calendar year. The participation of the outside directors of 
the Company is limited to 20% of shares available under the Stock Incentive 
Plan.

     The Stock Incentive Plan provides for awards in the form of restricted 
shares, stock units, options or SARs, or any combination thereof. No payment 
is required upon receipt of an award, except that a recipient of newly issued 
restricted shares must pay the par value of such restricted shares to the 
Company.

     RESTRICTED STOCK

     Restricted shares are shares of Common Stock that are subject to repurchase
by the Company at the employee's purchase price in the event that the applicable
vesting conditions are not satisfied, and they are nontransferable prior to
vesting (except for certain transfers to a trustee). Restricted shares have the
same voting and dividend rights as other shares of Common Stock.


                                       -14-


<PAGE>

     STOCK UNITS

     A stock unit is an unfunded bookkeeping entry representing the 
equivalent of one share of Common Stock, and is nontransferable prior to the 
holder's death. A holder of a stock unit has no voting rights or other 
privileges as a stockholder but may be entitled to receive dividend 
equivalents equal to the amount of dividends paid on the same number of 
shares of Common Stock. Dividend equivalents may be converted into additional 
stock units or settled in the form of cash, Common Stock or a combination of 
both. Stock units, when vested, may be settled by distributing shares of 
Common Stock or by a cash payment corresponding to the fair market value of 
an equivalent number of shares of Common Stock, or a combination of both. 
Vested stock units will be settled at the time determined by the Compensation 
Committee. If the time of settlement is deferred, interest or additional 
dividend equivalents may be credited on the deferred payment.

     The recipient of restricted shares or stock units may pay all projected 
withholding taxes relating to the award with Common Stock rather than cash.  

     OPTIONS

     Options may include nonstatutory stock options ("NSOs") as well as 
incentive stock options ("ISOs") intended to qualify for special tax 
treatment. The term of an ISO cannot exceed 10 years (five years for 10% 
stockholders), and the exercise price of an ISO must be equal to or greater 
than the fair market value of the Common Stock on the date of grant (or 110% 
of fair market value at the date of grant for 10% stockholders). The exercise 
price of an NSO must be equal to or greater than the par value of the Common 
Stock on the date of grant.

     The exercise price of an option may be paid in any lawful form permitted 
by the Compensation Committee, including (without limitation) the surrender 
of shares of Common Stock or restricted shares already owned by the optionee. 
The Compensation Committee may likewise permit optionees to satisfy their 
withholding tax obligation upon exercise of an NSO by surrendering a portion 
of their option shares to the Company. The Stock Incentive Plan also allows 
the optionee to pay the exercise price of an option by giving "exercise/sale" 
or "exercise/pledge" directions. If exercise/sale directions are given, a 
number of option shares sufficient to pay the exercise price and any 
withholding taxes is issued directly to a securities broker selected by the 
Company who, in turn, sells these shares in the open market. The broker 
remits to the Company the proceeds from the sale of these shares, and the 
optionee receives the remaining option shares. If exercise/ pledge directions 
are given, the option shares are issued directly to a securities broker or 
other lender selected by the Company. The broker or other lender will hold 
the shares as security and will extend credit for up to 50% of their market 
value. The loan proceeds will be paid to the Company to the extent necessary 
to pay the exercise price and any withholding taxes. Any excess loan proceeds 
may be paid to the optionee. If the loan proceeds are insufficient to cover 
the exercise price and withholding taxes, the optionee will be required to 
pay the deficiency to the Company at the time of exercise.

     STOCK APPRECIATION RIGHTS

     Stock appreciation rights ("SARs") permit the participant to elect to 
receive any appreciation in the value of the underlying stock from the 
Company, either in shares of Common Stock or in cash or a combination of the 
two, with the Compensation Committee having the discretion to determine the 
form in which such payment will be made. The amount payable on exercise of an 
SAR is measured by the difference between the market value of the underlying 
stock at exercise and the exercise price. SARs may, but need not, be granted 
in conjunction with options. Upon exercise of an SAR granted in tandem with 
an option, the corresponding portion of the related option must be 
surrendered and cannot thereafter be exercised. Conversely, upon exercise of 
an option to which an SAR is attached, the SAR may no longer be exercised to 
the extent that the corresponding option has been exercised. All options and 
SARs are nontransferable prior to the optionee's death.


                                       -15-


<PAGE>

     VESTING

     The Compensation Committee determines the number of restricted shares, 
stock units, options or SARs to be included in the award as well as the 
vesting and other conditions. The vesting conditions may be based on the 
employee's service, his or her individual performance, the Company's 
performance or other appropriate criteria. In general, the vesting conditions 
will be based on the employee's service after the date of grant. Vesting may 
be accelerated in the event of the employee's death, disability or retirement 
or in the event of a change in control with respect to the Company.

     OTHER PROVISIONS

     For purposes of the Stock Incentive Plan, the term "change in control" 
is defined as any one of the following: (i) any person is or becomes the 
beneficial owner, directly or indirectly, of at least 50% of the combined 
voting power of the Company's outstanding securities ordinarily having the 
right to vote at elections of directors; (ii) approval by the stockholders of 
the Company of a merger or consolidation of the Company with or into another 
corporation or entity or any other corporate reorganization in which over 50% 
of the combined voting power of the continuing or surviving entity 
immediately after the merger, consolidation or reorganization is owned by 
persons who were not stockholders of the Company immediately prior to the 
merger, consolidation or reorganization; or (iii) a change in the composition 
of the Board of Directors in which fewer than half of the incumbent Directors 
had been Directors 24 months prior to the change or were elected or nominated 
with the affirmative votes of Directors 24 months prior to the change.

     Awards under the Stock Incentive Plan may provide that if any payment 
(or transfer) by the Company to a recipient would be nondeductible by the 
Company for federal income tax purposes, then the aggregate present value of 
all such payments (or transfers) will be reduced to an amount which maximizes 
such value without causing any such payment (or transfer) to be nondeductible.

FEDERAL INCOME TAX CONSEQUENCES

     The following discussion of the federal income tax consequences of the 
Stock Incentive Plan as it relates to share awards, nonqualified stock 
options and incentive stock options is intended to be a summary of applicable 
federal law. State and local tax consequences may differ.

     SHARE AWARDS

     If a participant is awarded or purchases shares, the amount by which the 
fair market value of the shares on the date of award or purchase exceeds the 
amount paid for the shares will be taxed to the participant as ordinary 
income. The Company will be entitled to a deduction in the same amount 
provided it makes all required withholdings on the compensation element of 
the sale or award. The participant's tax basis in the shares acquired is 
equal to the share's fair market value on the date of acquisition. Upon a 
subsequent sale of any shares, the participant will realize capital gain or 
loss (long-term or short-term, depending on whether the shares were held for 
more than one year before the sale) in an amount equal to the difference 
between his or her basis in the shares and the sale price.

     If a participant is awarded or purchases shares that are subject to a 
vesting schedule, the participant is deemed to receive an amount of ordinary 
income equal to the excess of the fair market value of the shares at the time 
they vest over the amount (if any) paid for such shares by the participant.  
The Company is entitled to a deduction equal to the amount of the income 
recognized by the participant.

     Code Section 83(b) permits a participant to elect, within 30 days after 
the transfer of any shares subject to a vesting schedule to him or her, to be 
taxed at ordinary income rates on the excess of the fair market value of the 
shares at the time of the transfer over the amount (if any) paid by the 
participant for such shares. Withholding taxes apply at that time. If the 
participant makes a Section 83(b) election, any later


                                       -16-


<PAGE>

appreciation in the value of the shares is not taxed as ordinary income, but 
instead is taxed as capital gain when the shares are sold or transferred.

     OPTIONS

     Incentive stock options and nonqualified stock options are treated 
differently for federal income tax purposes. Incentive stock options are 
intended to comply with the requirements of Section 422 of the Code. 
Nonqualified stock options need not comply with such requirements.

     An optionee is generally not taxed on the grant or exercise of an 
incentive stock option. The difference between the exercise price and the 
fair market value of the shares on the exercise date will, however, be a 
preference item for purposes of the alternative minimum tax. If an optionee 
holds the shares acquired upon exercise of an incentive stock option for at 
least two years following grant and at least one year following exercise, the 
optionee's gain, if any, upon a subsequent disposition of such shares is a 
capital gain (or loss). The measure of the gain is the difference between the 
proceeds received on disposition and the optionee's basis in the shares 
(which generally equals the exercise price). If an optionee disposes of stock 
acquired pursuant to exercise of an incentive stock option before satisfying 
the one and two-year holding periods described above, the optionee will 
recognize both ordinary income and capital gain (or loss) in the year of 
disposition. The amount of the ordinary income will be the lesser of (i) the 
amount realized on disposition less the optionee's adjusted basis in the 
stock (usually the option price) or (ii) the difference between the fair 
market value of the stock on the exercise date and the option price. The 
balance of the consideration received on such a disposition will be capital 
gain if the stock had been held for at least one year following exercise of 
the incentive stock option.  The Company is not entitled to an income tax 
deduction on the grant or exercise of an incentive stock option or on the 
optionee's disposition of the shares after satisfying the holding period 
requirement described above.  If the holding periods are not satisfied, the 
Company will be entitled to a deduction in the year the optionee disposes of 
the shares, in an amount equal to the ordinary income recognized by the 
optionee.

     An optionee is not taxed on the grant of a nonqualified stock option. On 
exercise, however, the optionee recognizes ordinary income equal to the 
difference between the option price and the fair market value of the shares 
on the date of exercise.  The Company is entitled to an income tax deduction 
in the year of exercise in the amount recognized by the optionee as ordinary 
income. Any gain on subsequent disposition of the shares is a capital gain if 
the shares are held for at least one year following exercise.  The Company 
does not receive a deduction for this gain.

     1997 TAX LAW

     The recently enacted 1997 Tax Law provides for lower capital gains rates 
if stock is held for eighteen months.  The 1997 Tax Law also provides for 
even lower applicable capital gains rates for stock acquired after December 
31, 2000 in certain circumstances if the stock is held for at least five 
years.

STOCK INCENTIVE PLAN BENEFITS

     The Board is authorized, within the provisions of the Stock Incentive 
Plan, to amend the terms of outstanding restricted shares or stock units, to 
modify or extend outstanding options or SARs or to exchange new options for 
outstanding options, including outstanding options with a higher exercise 
price than the new options.  Therefore, the benefits and amounts that will be 
received by each of the Named Executive Officers as a group and all other key 
employees are not determinable.

   THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE ADOPTION OF THE AMENDMENT
  AND RESTATEMENT OF THE BIOSITE DIAGNOSTICS INCORPORATED STOCK INCENTIVE PLAN.


                                       -17-


<PAGE>


                                      PROPOSAL 3
                   APPROVAL OF THE AMENDMENT AND RESTATEMENT OF THE
            BIOSITE DIAGNOSTICS INCORPORATED EMPLOYEE STOCK PURCHASE PLAN

     In order to provide employees of the Company with an opportunity to 
purchase Common Stock at a discount through payroll deductions, the Board of 
Directors originally adopted the Biosite Diagnostics Incorporated Employee 
Stock Purchase Plan on December 5, 1996 under which 100,000 shares of Common 
Stock were reserved for issuance (subject to anti-dilution provisions).  On 
February 27, 1998, the Board of Directors amended and restated the plan (as 
amended and restated, the "ESPP"), subject to the approval of the Company's 
stockholders at the Annual Meeting, to reserve an additional 250,000 shares 
for issuance under the ESPP and to provide the Committee (as defined in the 
ESPP) with greater flexibility in the event there are insufficient shares to 
accommodate purchases during the following six month purchase period.  As of 
March 31, 1998, an aggregate of 45,246 shares were available for issuance 
under the ESPP (which number does not include the 250,000 share increase that 
stockholders are being asked to approve).

     The full text of the ESPP, substantially in the form in which it will 
take effect if the ESPP is approved by the stockholders, is set forth in 
Exhibit B to this Proxy Statement.  The following description of the ESPP is 
a summary only. It is subject to, and qualified in its entirety by, Exhibit B.

     Under the ESPP, an aggregate of 350,000 shares of Common Stock (which 
number includes the 250,000 share increase that stockholders are being asked 
to approve) have been reserved for issuance, subject to anti-dilution 
adjustments. Each regular full-time and part-time employee who works an 
average of over 20 hours per week will be eligible to participate in the ESPP 
at the beginning of the first participation period after the employee's date 
of hire.  Eligible employees may elect to contribute up to 15% of their cash 
compensation during each six-month "purchase period," subject to certain 
statutory limits. Participants may withdraw their contributions at any time 
before the close of the purchase period.

     At the end of each purchase period, the Company will apply the amount 
contributed by the participant during that period to purchase shares of 
Company Common Stock, but not more than 2,500 shares.  Shares of Company 
Common Stock are purchased for 85% of the lower of (i) the market price of 
Company Common Stock immediately before the beginning of the applicable 
"offering period" or (ii) the market price of Company Common Stock on the 
last business day of the purchase period.  In general, each offering period 
is 24 months long, but a new offering period begins every six months.  Thus, 
up to four overlapping periods may be in effect at the same time.  If the 
market price of Company Common Stock is lower when a subsequent offering 
period begins, the subsequent offering period automatically becomes the 
applicable offering period.  A participant cannot purchase Company Common 
Stock valued at greater than $25,000 in any one year (measured at the 
beginning of the offering periods). All expenses incurred in connection with 
the implementation and administration of the ESPP will be paid by the Company.

FEDERAL INCOME TAX CONSEQUENCES

     The ESPP is intended to qualify as an "employee stock purchase plan" 
under section 423 of the Internal Revenue Code (the "Code").  No income is 
recognized by a participant at the time a right to purchase Company Common 
Stock is granted.  Likewise, no taxable income is recognized at the time of 
the purchase, even though the purchase price reflects a discount from the 
market value of the shares at that time.

     A participant must recognize taxable income upon a disposition of shares 
acquired under the ESPP.  The tax treatment may be more favorable if the 
disposition occurs after the holding-period requirements of section 423 have 
been satisfied.  To satisfy the holding-period requirements of section 423, 
shares acquired under the Plan cannot be disposed of within two years after 
the FIRST day of the offering period during which the shares are purchased.  
They also cannot be disposed of within one year after they are purchased.


                                       -18-


<PAGE>

     If the holding period is met, the participant recognizes ordinary income 
equal to the LOWER of (a) the excess of the fair market value of the shares 
on the date of the disposition over the actual purchase price or (b) 15% of 
the fair market value of the shares immediately before the applicable 
offering period.  The Company will not be entitled to any deduction under 
these circumstances.

     The excess, if any, of the fair market value of the shares on the date 
of the disposition over the sum of the purchase price plus the amount of 
ordinary income recognized (as described above) will be taxed as a capital 
gain.  If a taxable disposition produces a loss (i.e., the fair market value 
of the shares on the date of the disposition is less than the purchase price) 
and the disposition involves certain unrelated parties, then the loss will be 
a long-term capital loss.

     If the holding period is not met, the entire difference between the 
purchase price and the market value of the shares on the date of purchase 
will be taxed to the participant as ordinary income in the year of 
disposition.  The Company will generally be entitled to a deduction for the 
same amount.

     The excess, if any, of the market value of the shares on the date of 
disposition over their market value on the date of purchase will be taxed as 
a capital gain (long term or short-term, depending on how long the shares 
have been held).  If the value of the shares on the date of disposition is 
less than their value on the date of purchase, then the difference will 
result in a capital loss (long-term or short-term, depending upon the holding 
period), provided the disposition involves certain unrelated parties.  Any 
such loss will not affect the ordinary income recognized upon the disposition.

     1997 TAX LAW

     In August 1997 new tax legislation was enacted (the "1997 Tax Law") 
which provides for lower capital gains rates if stock is held for eighteen 
months. The 1997 Tax Law also provides for even lower applicable capital 
gains rates for stock acquired after December 31, 2000 in certain 
circumstances if the stock is held for at least five years.

  THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE ADOPTION OF THE AMENDMENT
       AND RESTATEMENT OF THE BIOSITE DIAGNOSTICS INCORPORATED
                  EMPLOYEE STOCK PURCHASE PLAN.

                              PROPOSAL 4
                RATIFICATION OF INDEPENDENT AUDITORS

     The Board of Directors, upon recommendation of the Audit Committee, has 
appointed the firm of Ernst & Young LLP ("Ernst & Young") as the Company's 
independent auditors for the fiscal year ended December 31, 1998, subject to 
ratification by the stockholders.  Representatives of Ernst & Young are 
expected to be present at the Company's Annual Meeting.  They will have an 
opportunity to make a statement, if they desire to do so, and will be 
available to respond to appropriate questions.

   THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR RATIFICATION OF THE APPOINTMENT
                              OF ERNST & YOUNG LLP.


                              STOCKHOLDER PROPOSALS

     To be considered for inclusion in the proxy statement for presentation 
at the Annual Meeting of Stockholders to be held in 1999 a stockholder 
proposal must be received at the offices of the Company, 11030 Roselle 
Street, San Diego, CA 92121 not later than December 17, 1998.


                                       -19-


<PAGE>

            SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

     Under Section 16(a) under the Securities Exchange Act of 1934, as 
amended (the "Exchange Act"),  the Company's directors, executive officers, 
and any persons holding more than 10% of the Company's Common Stock are 
required to report their initial ownership of the Company's Common Stock and 
any subsequent changes in that ownership to the SEC.  Specific due dates for 
these reports have been established and the Company is required to identify 
in this Proxy Statement those persons who failed to timely file these 
reports.  The Company has previously disclosed the delinquent filings of Form 
3s in its 10-K for the fiscal year ended December 31, 1996.  All of the 
remaining filing requirements were satisfied for 1997.

                                  OTHER MATTERS

     The Board of Directors knows of no other business that will be presented 
at the Annual Meeting.  If any other business is properly brought before the 
Annual Meeting, it is intended that proxies in the enclosed form will be 
voted in accordance with the judgment of the persons voting the proxies.

     Any stockholder or stockholder's representative who, because of a 
disability, may need special assistance or accommodation to allow him or her 
to participate at the Annual Meeting may request reasonable assistance or 
accommodation from the Company by contacting Biosite Diagnostics 
Incorporated, 11030 Roselle Street, San Diego, California, 92121, (619) 
455-4808.  To provide the Company sufficient time to arrange for reasonable 
assistance or accommodation, please submit all requests by May 7, 1998.

     Whether you intend to be present at the Annual Meeting or not, we urge 
you to return your signed proxy promptly.

                                        By order of the Board of Directors.



                                        Kim D. Blickenstaff
                                        President, Chief Executive Officer,
                                        Secretary and Treasurer



                                       -20-



<PAGE>
                                                                    EXHIBIT A



                           BIOSITE DIAGNOSTICS INCORPORATED

                                 AMENDED AND RESTATED

                              1996 STOCK INCENTIVE PLAN


     ARTICLE 1.  INTRODUCTION.

     The Plan was adopted by the Board on December 5, 1996, and was approved 
by the Company's stockholders on December 6, 1996.  The Plan is effective 
December 1, 1996.  However, Articles 7, 8 and 9 shall not apply prior to the 
Company's initial public offering.  On February 27, 1998, the Plan was 
amended by the Board to increase the number of shares under the Plan.

     The purpose of the Plan is to promote the long-term success of the 
Company and the creation of stockholder value by (a) encouraging Key 
Employees to focus on critical long-range objectives, (b) encouraging the 
attraction and retention of Key Employees with exceptional qualifications and 
(c) linking Key Employees directly to stockholder interests through increased 
stock ownership.  The Plan seeks to achieve this purpose by providing for 
Awards in the form of Restricted Shares, Stock Units, Options (which may 
constitute incentive stock options or nonstatutory stock options) or stock 
appreciation rights.

     The Plan shall be governed by, and construed in accordance with, the 
laws of the State of California.

     ARTICLE 2.  ADMINISTRATION.

     2.1    COMMITTEE COMPOSITION.  The Plan shall be administered by the 
Committee.  Except as provided below, the Committee shall consist exclusively 
of directors of the Company, who shall be appointed by the Board.  In 
addition, the composition of the Committee shall satisfy:

            (a)  Such requirements, if any, as the Securities and Exchange
     Commission may establish for administrators acting under plans intended to
     qualify for exemption under Rule 16b-3 (or its successor) under the
     Exchange Act; and

            (b)  Such requirements as the Internal Revenue Service may establish
     for outside directors acting under plans intended to qualify for exemption
     under section 162(m)(4)(C) of the Code.

The Board may act on its own behalf with respect to Outside Directors and may 
also appoint one or more separate committees composed of one or more officers 
of the Company who need not be directors of the Company and who need not 
satisfy the foregoing requirements, who may administer the Plan with respect 
to Key Employees who are not "covered employees" under section 162(m)(3) of 
the Code and who are not required to report pursuant to Section 16(a) of the 
Exchange Act.

     2.2    COMMITTEE RESPONSIBILITIES.  The Committee shall (a) select the 
Key Employees who are to receive Awards under the Plan, (b) determine the 
type, number, vesting requirements and other features and conditions of such 
Awards, (c) interpret the Plan and (d) make all other decisions relating to 
the operation of the Plan.  The Committee may adopt such rules or guidelines 
as it deems appropriate to implement the Plan.  The Committee's 
determinations under the Plan shall be final and binding on all persons.


                                       A-1


<PAGE>


     ARTICLE 3.     SHARES AVAILABLE FOR GRANTS.

     3.1   BASIC LIMITATION.  Common Shares issued pursuant to the Plan may 
be authorized but unissued shares or treasury shares.  The aggregate number 
of Common Shares available for Restricted Shares, Stock Units, Options and 
SARs awarded under the Plan shall not exceed 1,400,000.  Of the Common Shares 
available hereunder, no more than 20% in aggregate shall be available with 
respect to Outside Directors.  The limitation of this Section 3.1 shall be 
subject to adjustment pursuant to Article 10.  The number of Common Shares 
available under this Plan shall be increased by unexercised or forfeited 
Common Shares under the Company's 1989 Stock Plan.

     3.2    ADDITIONAL SHARES.  If Stock Units, Options or SARs are forfeited 
or if Options or SARs terminate for any other reason before being exercised, 
then the corresponding Common Shares shall again become available for Awards 
under the Plan.  If Restricted Shares are forfeited before any dividends have 
been paid with respect to such Shares, then such Shares shall again become 
available for Awards under the Plan.  If Stock Units are settled, then only 
the number of Common Shares (if any) actually issued in settlement of such 
Stock Units shall reduce the number available under Section 3.1 and the 
balance shall again become available for Awards under the Plan.  If SARs are 
exercised, then only the number of Common Shares (if any) actually issued in 
settlement of such SARs shall reduce the number available under Section 3.1 
and the balance shall again become available for Awards under the Plan.

     3.3    DIVIDEND EQUIVALENTS.  Any dividend equivalents distributed under 
the Plan shall not be applied against the number of Restricted Shares, Stock 
Units, Options or SARs available for Awards, whether or not such dividend 
equivalents are converted into Stock Units.

     ARTICLE 4.     ELIGIBILITY.

     4.1    GENERAL RULES.  Only Key Employees (including, without 
limitation, independent contractors who are not members of the Board) shall 
be eligible for designation as Participants by the Committee.

     4.2    OUTSIDE DIRECTORS.  The Committee may provide that the NSOs that 
otherwise would be granted to an Outside Director under this Plan shall 
instead be granted to an affiliate of such Outside Director.  Such affiliate 
shall then be deemed to be an Outside Director for purposes of the Plan, 
provided that the service-related vesting and termination provisions 
pertaining to the NSOs shall be applied with regard to the service of the 
Outside Director.

     4.3    INCENTIVE STOCK OPTIONS.  Only Key Employees who are common-law 
employees of the Company, a Parent or a Subsidiary shall be eligible for the 
grant of ISOs.  In addition, a Key Employee who owns more than 10% of the 
total combined voting power of all classes of outstanding stock of the 
Company or any of its Parents or Subsidiaries shall not be eligible for the 
grant of an ISO unless the requirements set forth in section 422(c)(6) of the 
Code are satisfied.

     ARTICLE 5.     OPTIONS.

     5.1    STOCK OPTION AGREEMENT.  Each grant of an Option under the Plan 
shall be evidenced by a Stock Option Agreement between the Optionee and the 
Company.  Such Option shall be subject to all applicable terms of the Plan 
and may be subject to any other terms that are not inconsistent with the 
Plan.  The Stock Option Agreement shall specify whether the Option is an ISO 
or an NSO. The provisions of the various Stock Option Agreements entered into 
under the Plan need not be identical.  Options may be granted in 
consideration of a cash payment or in consideration of a reduction in the 
Optionee's other compensation. A Stock Option Agreement may provide that a 
new Option will be granted automatically to the Optionee when he or she 
exercises a prior Option and pays the Exercise Price in the form described in 
Section 6.2.

     5.2    NUMBER OF SHARES.  Each Stock Option Agreement shall specify the 
number of Common Shares subject to the Option and shall provide for the 
adjustment of such number in accordance with Article 10.  


                                       A-2


<PAGE>

Options granted to any Optionee in a single calendar year shall in no event 
cover more than 250,000 Common Shares, subject to adjustment in accordance 
with Article 10.

     5.3    EXERCISE PRICE.  Each Stock Option Agreement shall specify the 
Exercise Price; provided that the Exercise Price under an ISO shall in no 
event be less than 100% of the Fair Market Value of a Common Share on the 
date of grant and the Exercise Price under an NSO shall in no event be less 
than the par value of the Common Shares subject to such NSO.  In the case of 
an NSO, a Stock Option Agreement may specify an Exercise Price that varies in 
accordance with a predetermined formula while the NSO is outstanding, 
provided that prior to the Company's initial public offering, the NSO 
Exercise Price shall be at least 85% (110% for 10% shareholders) of the Fair 
Market Value of a Common Share of Stock on the date of grant.

     5.4    EXERCISABILITY AND TERM.  Each Stock Option Agreement shall 
specify the date when all or any installment of the Option is to become 
exercisable, provided that prior to the Company's initial public offering, 
Options shall become exercisable pursuant to a schedule providing for at 
least 20% vesting per year over a five-year period (or, in the case of 
performance options, to the extent permitted under applicable regulations of 
the California Department of Corporations).  The Stock Option Agreement shall 
also specify the term of the Option; provided that the term of an ISO shall 
in no event exceed 10 years from the date of grant.  A Stock Option Agreement 
may provide for accelerated exercisability in the event of the Optionee's 
death, disability or retirement or other events and may provide for 
expiration prior to the end of its term in the event of the termination of 
the Optionee's service.  Notwithstanding the foregoing, no Options may be 
accelerated prior to the Company's initial public offering.

     Options may be awarded in combination with SARs, and such an Award may 
provide that the Options will not be exercisable unless the related SARs are 
forfeited.  NSOs may also be awarded in combination with Restricted Shares or 
Stock Units, and such an Award may provide that the NSOs will not be 
exercisable unless the related Restricted Shares or Stock Units are forfeited.

     Prior to the Company's initial public offering, Options must be 
exercised within 30 days of the termination of employment (six months for 
termination on account of death or disability).

     5.5    EFFECT OF CHANGE IN CONTROL.  The Committee may determine, at the 
time of granting an Option or thereafter, that such Option shall become fully 
exercisable as to all Common Shares subject to such Option in the event that 
a Change in Control occurs with respect to the Company.

     5.6    MODIFICATION OR ASSUMPTION OF OPTIONS.  Within the limitations of 
the Plan, the Committee may modify, extend or assume outstanding options or 
may accept the cancellation of outstanding options (whether granted by the 
Company or by another issuer) in return for the grant of new options for the 
same or a different number of shares and at the same or a different exercise 
price.  The foregoing notwithstanding, no modification of an Option shall, 
without the consent of the Optionee, alter or impair his or her rights or 
obligations under such Option.

     5.7    OTHER REQUIREMENTS PRIOR TO COMPANY'S INITIAL PUBLIC OFFERING. 
Prior to the Company's initial public offering, Optionees shall receive 
Company financial statements at least annually.

     ARTICLE 6.     PAYMENT FOR OPTION SHARES.

     6.1    GENERAL RULE.  The entire Exercise Price of Common Shares issued 
upon exercise of Options shall be payable in cash at the time when such 
Common Shares are purchased, except as follows:

            (a) In the case of an ISO granted under the Plan, payment shall be
     made only pursuant to the express provisions of the applicable Stock Option
     Agreement.  The Stock Option Agreement may specify that payment may be made
     in any form(s) described in this Article 6.


                                       A-3


<PAGE>


            (b) In the case of an NSO, the Committee may at any time accept
     payment in any form(s) described in this Article 6.

     6.2    SURRENDER OF STOCK.  To the extent that this Section 6.2 is 
applicable, payment for all or any part of the Exercise Price may be made 
with Common Shares which have already been owned by the Optionee for more 
than six months.  Such Common Shares shall be valued at their Fair Market 
Value on the date when the new Common Shares are purchased under the Plan.

     6.3    EXERCISE/SALE.  To the extent that this Section 6.3 is 
applicable, payment may be made by the delivery (on a form prescribed by the 
Company) of an irrevocable direction to a securities broker approved by the 
Company to sell Common Shares and to deliver all or part of the sales 
proceeds to the Company in payment of all or part of the Exercise Price and 
any withholding taxes.

     6.4    EXERCISE/PLEDGE.  To the extent that this Section 6.4 is 
applicable, payment may be made by the delivery (on a form prescribed by the 
Company) of an irrevocable direction to pledge Common Shares to a securities 
broker or lender approved by the Company, as security for a loan, and to 
deliver all or part of the loan proceeds to the Company in payment of all or 
part of the Exercise Price and any withholding taxes.

     6.5    PROMISSORY NOTE.  To the extent that this Section 6.5 is 
applicable, payment may be made with a full-recourse promissory note; 
provided that the par value of the Common Shares shall be paid in cash.

     6.6    OTHER FORMS OF PAYMENT.  To the extent that this Section 6.6 is 
applicable, payment may be made in any other form that is consistent with 
applicable laws, regulations and rules.

     ARTICLE 7.     STOCK APPRECIATION RIGHTS.

     7.1    SAR AGREEMENT.  Each grant of an SAR under the Plan shall be 
evidenced by an SAR Agreement between the Optionee and the Company.  Such SAR 
shall be subject to all applicable terms of the Plan and may be subject to 
any other terms that are not inconsistent with the Plan.  The provisions of 
the various SAR Agreements entered into under the Plan need not be identical. 
SARs may be granted in consideration of a reduction in the Optionee's other 
compensation.

     7.2    NUMBER OF SHARES.  Each SAR Agreement shall specify the number of 
Common Shares to which the SAR pertains and shall provide for the adjustment 
of such number in accordance with Article 10.  SARs granted to any Optionee 
in a single calendar year shall in no event pertain to more than 250,000 
Common Shares, subject to adjustment in accordance with Article 10.

     7.3    EXERCISE PRICE.  Each SAR Agreement shall specify the Exercise 
Price.  An SAR Agreement may specify an Exercise Price that varies in 
accordance with a predetermined formula while the SAR is outstanding.

     7.4    EXERCISABILITY AND TERM.  Each SAR Agreement shall specify the 
date when all or any installment of the SAR is to become exercisable.  The 
SAR Agreement shall also specify the term of the SAR.  An SAR Agreement may 
provide for accelerated exercisability in the event of the Optionee's death, 
disability or retirement or other events and may provide for expiration prior 
to the end of its term in the event of the termination of the Optionee's 
service.  SARs may also be awarded in combination with Options, Restricted 
Shares or Stock Units, and such an Award may provide that the SARs will not 
be exercisable unless the related Options, Restricted Shares or Stock Units 
are forfeited.  An SAR may be included in an ISO only at the time of grant 
but may be included in an NSO at the time of grant or thereafter.  An SAR 
granted under the Plan may provide that it will be exercisable only in the 
event of a Change in Control.

     7.5    EFFECT OF CHANGE IN CONTROL.  The Committee may determine, at the 
time of granting an SAR or thereafter, that such SAR shall become fully 
exercisable as to all Common Shares subject to such SAR in the event that a 
Change in Control occurs with respect to the Company.


                                       A-4


<PAGE>


     7.6    EXERCISE OF SARS.  The exercise of an SAR shall be subject to the 
restrictions imposed by Rule 16b-3 (or its successor) under the Exchange Act, 
if applicable.  If, on the date when an SAR expires, the Exercise Price under 
such SAR is less than the Fair Market Value on such date but any portion of 
such SAR has not been exercised or surrendered, then such SAR shall 
automatically be deemed to be exercised as of such date with respect to such 
portion.  Upon exercise of an SAR, the Optionee (or any person having the 
right to exercise the SAR after his or her death) shall receive from the 
Company (a) Common Shares, (b) cash or (c) a combination of Common Shares and 
cash, as the Committee shall determine.  The amount of cash and/or the Fair 
Market Value of Common Shares received upon exercise of SARs shall, in the 
aggregate, be equal to the amount by which the Fair Market Value (on the date 
of surrender) of the Common Shares subject to the SARs exceeds the Exercise 
Price.

     7.7    MODIFICATION OR ASSUMPTION OF SARS.  Within the limitations of 
the Plan, the Committee may modify, extend or assume outstanding SARs or may 
accept the cancellation of outstanding SARs (whether granted by the Company 
or by another issuer) in return for the grant of new SARs for the same or a 
different number of shares and at the same or a different exercise price.  
The foregoing notwithstanding, no modification of an SAR shall, without the 
consent of the Optionee, alter or impair his or her rights or obligations 
under such SAR.

     ARTICLE 8.     RESTRICTED SHARES AND STOCK UNITS.

     8.1    TIME, AMOUNT AND FORM OF AWARDS.  Awards under the Plan may be 
granted in the form of Restricted Shares, in the form of Stock Units, or in 
any combination of both.  Restricted Shares or Stock Units may also be 
awarded in combination with NSOs or SARs, and such an Award may provide that 
the Restricted Shares or Stock Units will be forfeited in the event that the 
related NSOs or SARs are exercised.

     8.2    PAYMENT FOR AWARDS.  To the extent that an Award is granted in 
the form of newly issued Restricted Shares, the Award recipient, as a 
condition to the grant of such Award, shall be required to pay the Company in 
cash an amount equal to the par value of such Restricted Shares.  To the 
extent that an Award is granted in the form of Restricted Shares from the 
Company's treasury or in the form of Stock Units, no cash consideration shall 
be required of the Award recipients.

     8.3    VESTING CONDITIONS.  Each Award of Restricted Shares or Stock 
Units shall become vested, in full or in installments, upon satisfaction of 
the conditions specified in the Stock Award Agreement.  A Stock Award 
Agreement may provide for accelerated vesting in the event of the 
Participant's death, disability or retirement or other events.  The Committee 
may determine, at the time of making an Award or thereafter, that such Award 
shall become fully vested in the event that a Change in Control occurs with 
respect to the Company.

     8.4    FORM AND TIME OF SETTLEMENT OF STOCK UNITS.  Settlement of vested 
Stock Units may be made in the form of (a) cash, (b) Common Shares or (c) any 
combination of both, as determined by the Committee.  The actual number of 
Stock Units eligible for settlement may be larger or smaller than the number 
included in the original Award, based on predetermined performance factors.  
Methods of converting Stock Units into cash may include (without limitation) 
a method based on the average Fair Market Value of Common Shares over a 
series of trading days. Vested Stock Units may be settled in a lump sum or in 
installments.  The distribution may occur or commence when all vesting 
conditions applicable to the Stock Units have been satisfied or have lapsed, 
or it may be deferred to any later date.  The amount of a deferred 
distribution may be increased by an interest factor or by dividend 
equivalents.  Until an Award of Stock Units is settled, the number of such 
Stock Units shall be subject to adjustment pursuant to Article 10.

     8.5    DEATH OF RECIPIENT.  Any Stock Units Award that becomes payable 
after the recipient's death shall be distributed to the recipient's 
beneficiary or beneficiaries.  Each recipient of a Stock Units Award under 
the Plan shall designate one or more beneficiaries for this purpose by filing 
the prescribed form with the Company.  A beneficiary designation may be 
changed by filing the prescribed form with the Company at any time before the 
Award recipient's death. If no beneficiary was designated or if no designated 
beneficiary

                                       A-5


<PAGE>

survives the Award recipient, then any Stock Units Award that becomes payable 
after the recipient's death shall be distributed to the recipient's estate.

     8.6    CREDITORS' RIGHTS.  A holder of Stock Units shall have no rights 
other than those of a general creditor of the Company.  Stock Units represent 
an unfunded and unsecured obligation of the Company, subject to the terms and 
conditions of the applicable Stock Award Agreement.

     ARTICLE 9.     VOTING AND DIVIDEND RIGHTS.

     9.1    RESTRICTED SHARES.  The holders of Restricted Shares awarded 
under the Plan shall have the same voting, dividend and other rights as the 
Company's other stockholders.  A Stock Award Agreement, however, may require 
that the holders of Restricted Shares invest any cash dividends received in 
additional Restricted Shares.  Such additional Restricted Shares shall be 
subject to the same conditions and restrictions as the Award with respect to 
which the dividends were paid.  Such additional Restricted Shares shall not 
reduce the number of Common Shares available under Article 3.

     9.2    STOCK UNITS.  The holders of Stock Units shall have no voting 
rights.  Prior to settlement or forfeiture, any Stock Unit awarded under the 
Plan may, at the Committee's discretion, carry with it a right to dividend 
equivalents.  Such right entitles the holder to be credited with an amount 
equal to all cash dividends paid on one Common Share while the Stock Unit is 
outstanding.  Dividend equivalents may be converted into additional Stock 
Units. Settlement of dividend equivalents may be made in the form of cash, in 
the form of Common Shares, or in a combination of both.  Prior to 
distribution, any dividend equivalents which are not paid shall be subject to 
the same conditions and restrictions as the Stock Units to which they attach.

     ARTICLE 10.    PROTECTION AGAINST DILUTION.

     10.1   ADJUSTMENTS.  In the event of a subdivision of the outstanding 
Common Shares, a declaration of a dividend payable in Common Shares, a 
declaration of a dividend payable in a form other than Common Shares in an 
amount that has a material effect on the price of Common Shares, a 
combination or consolidation of the outstanding Common Shares (by 
reclassification or otherwise) into a lesser number of Common Shares, a 
recapitalization, a spinoff or a similar occurrence, the Committee shall make 
such adjustments as it, in its sole discretion, deems appropriate in one or 
more of (a) the number of Options, SARs, Restricted Shares and Stock Units 
available for future Awards under Article 3, (b) the limitations set forth in 
Sections 5.2 and 7.2, (c) the number of NSOs to be granted to Outside 
Directors under Section 4.2, (d) the number of Stock Units included in any 
prior Award which has not yet been settled, (e) the number of Common Shares 
covered by each outstanding Option and SAR or (f) the Exercise Price under 
each outstanding Option and SAR.  Except as provided in this Article 10, a 
Participant shall have no rights by reason of any issue by the Company of 
stock of any class or securities convertible into stock of any class, any 
subdivision or consolidation of shares of stock of any class, the payment of 
any stock dividend or any other increase or decrease in the number of shares 
of stock of any class.

     10.2   REORGANIZATIONS.  In the event that the Company is a party to a 
merger or other reorganization, outstanding Options, SARs, Restricted Shares 
and Stock Units shall be subject to the agreement of merger or 
reorganization.  Such agreement may provide, without limitation, for the 
assumption of outstanding Awards by the surviving corporation or its parent, 
for their continuation by the Company (if the Company is a surviving 
corporation), for accelerated vesting and accelerated expiration (provided 
the Company has previously had its initial public offering), or for 
settlement in cash.

     ARTICLE 11.    AWARDS UNDER OTHER PLANS.

     The Company may grant awards under other plans or programs.  Such awards 
may be settled in the form of Common Shares issued under this Plan.  Such 
Common Shares shall be treated for all purposes under the Plan like Common 
Shares issued in settlement of Stock Units and shall, when issued, reduce the 
number of Common Shares available under Article 3.


                                       A-6


<PAGE>


     ARTICLE 12.    PAYMENT OF DIRECTOR'S FEES IN SECURITIES.

     12.1   EFFECTIVE DATE.  No provision of this Article 12 shall be 
effective unless and until the Board has determined to implement such 
provision.

     12.2   ELECTIONS TO RECEIVE NSOS, RESTRICTED SHARES OR STOCK UNITS.  An 
Outside Director may elect to receive his or her annual retainer payments and 
meeting fees from the Company in the form of cash, NSOs, Restricted Shares, 
Stock Units, or a combination thereof, as determined by the Board.  Such 
NSOs, Restricted Shares and Stock Units shall be issued under the Plan.  An 
election under this Article 12 shall be filed with the Company on the 
prescribed form.

     12.3   NUMBER AND TERMS OF NSOS, RESTRICTED SHARES OR STOCK UNITS.  The 
number of NSOs, Restricted Shares or Stock Units to be granted to Outside 
Directors in lieu of annual retainers and meeting fees that would otherwise 
be paid in cash shall be calculated in a manner determined by the Board.  The 
terms of such NSOs, Restricted Shares or Stock Units shall also be determined 
by the Board.

     ARTICLE 13.    LIMITATION ON RIGHTS.

     13.1   RETENTION RIGHTS.  Neither the Plan nor any Award granted under 
the Plan shall be deemed to give any individual a right to remain an 
employee, consultant or director of the Company, a Parent or a Subsidiary.  
The Company and its Parents and Subsidiaries reserve the right to terminate 
the service of any employee, consultant or director at any time, with or 
without cause, subject to applicable laws, the Company's certificate of 
incorporation and by-laws and a written employment agreement (if any).

     13.2   STOCKHOLDERS' RIGHTS.  A Participant shall have no dividend 
rights, voting rights or other rights as a stockholder with respect to any 
Common Shares covered by his or her Award prior to the issuance of a stock 
certificate for such Common Shares.  No adjustment shall be made for cash 
dividends or other rights for which the record date is prior to the date when 
such certificate is issued, except as expressly provided in Articles 8, 9 and 
10.

     13.3   REGULATORY REQUIREMENTS.  Any other provision of the Plan 
notwithstanding, the obligation of the Company to issue Common Shares under 
the Plan shall be subject to all applicable laws, rules and regulations and 
such approval by any regulatory body as may be required.  The Company 
reserves the right to restrict, in whole or in part, the delivery of Common 
Shares pursuant to any Award prior to the satisfaction of all legal 
requirements relating to the issuance of such Common Shares, to their 
registration, qualification or listing or to an exemption from registration, 
qualification or listing.

     ARTICLE 14.    LIMITATION ON PAYMENTS.

     14.1   BASIC RULE.  Any provision of the Plan to the contrary 
notwithstanding, in the event that the independent auditors most recently 
selected by the Board (the "Auditors") determine that any payment or transfer 
by the Company under the Plan to or for the benefit of a Participant (a 
"Payment") would be nondeductible by the Company for federal income tax 
purposes because of the provisions concerning "excess parachute payments" in 
section 280G of the Code, then the aggregate present value of all Payments 
shall be reduced (but not below zero) to the Reduced Amount; provided that 
the Committee, at the time of making an Award under this Plan or at any time 
thereafter, may specify in writing that such Award shall not be so reduced 
and shall not be subject to this Article 14.  For purposes of this Article 
14, the "Reduced Amount" shall be the amount, expressed as a present value, 
which maximizes the aggregate present value of the Payments without causing 
any Payment to be nondeductible by the Company because of section 280G of the 
Code.

     14.2   REDUCTION OF PAYMENTS.  If the Auditors determine that any 
Payment would be nondeductible by the Company because of section 280G of the 
Code, then the Company shall promptly give the Participant notice to that 
effect and a copy of the detailed calculation thereof and of the Reduced 
Amount, and the

                                       A-7


<PAGE>

Participant may then elect, in his or her sole discretion, which and how much 
of the Payments shall be eliminated or reduced (as long as after such 
election the aggregate present value of the Payments equals the Reduced 
Amount) and shall advise the Company in writing of his or her election within 
10 days of receipt of notice.  If no such election is made by the Participant 
within such 10-day period, then the Company may elect which and how much of 
the Payments shall be eliminated or reduced (as long as after such election 
the aggregate present value of the Payments equals the Reduced Amount) and 
shall notify the Participant promptly of such election.  For purposes of this 
Article 14, present value shall be determined in accordance with section 
280G(d)(4) of the Code. All determinations made by the Auditors under this 
Article 14 shall be binding upon the Company and the Participant and shall be 
made within 60 days of the date when a Payment becomes payable or 
transferable.  As promptly as practicable following such determination and 
the elections hereunder, the Company shall pay or transfer to or for the 
benefit of the Participant such amounts as are then due to him or her under 
the Plan and shall promptly pay or transfer to or for the benefit of the 
Participant in the future such amounts as become due to him or her under the 
Plan.

     14.3   OVERPAYMENTS AND UNDERPAYMENTS.  As a result of uncertainty in 
the application of section 280G of the Code at the time of an initial 
determination by the Auditors hereunder, it is possible that Payments will 
have been made by the Company which should not have been made (an 
"Overpayment") or that additional Payments which will not have been made by 
the Company could have been made (an "Underpayment"), consistent in each case 
with the calculation of the Reduced Amount hereunder.  In the event that the 
Auditors, based upon the assertion of a deficiency by the Internal Revenue 
Service against the Company or the Participant which the Auditors believe has 
a high probability of success, determine that an Overpayment has been made, 
such Overpayment shall be treated for all purposes as a loan to the 
Participant which he or she shall repay to the Company, together with 
interest at the applicable federal rate provided in section 7872(f)(2) of the 
Code; provided, however, that no amount shall be payable by the Participant 
to the Company if and to the extent that such payment would not reduce the 
amount which is subject to taxation under section 4999 of the Code.  In the 
event that the Auditors determine that an Underpayment has occurred, such 
Underpayment shall promptly be paid or transferred by the Company to or for 
the benefit of the Participant, together with interest at the applicable 
federal rate provided in section 7872(f)(2) of the Code.

     14.4   RELATED CORPORATIONS.  For purposes of this Article 14, the term 
"Company" shall include affiliated corporations to the extent determined by 
the Auditors in accordance with section 280G(d)(5) of the Code.

     ARTICLE 15.    WITHHOLDING TAXES.

     15.1   GENERAL.  To the extent required by applicable federal, state, 
local or foreign law, a Participant or his or her successor shall make 
arrangements satisfactory to the Company for the satisfaction of any 
withholding tax obligations that arise in connection with the Plan.  The 
Company shall not be required to issue any Common Shares or make any cash 
payment under the Plan until such obligations are satisfied.

     15.2   SHARE WITHHOLDING.  The Committee may permit a Participant to 
satisfy all or part of his or her withholding or income tax obligations by 
having the Company withhold all or a portion of any Common Shares that 
otherwise would be issued to him or her or by surrendering all or a portion 
of any Common Shares that he or she previously acquired.  Such Common Shares 
shall be valued at their Fair Market Value on the date when taxes otherwise 
would be withheld in cash.  Any payment of taxes by assigning Common Shares 
to the Company may be subject to restrictions, including any restrictions 
required by rules of the Securities and Exchange Commission.

     ARTICLE 16.    ASSIGNMENT OR TRANSFER OF AWARDS.

     16.1   GENERAL.  An Award granted under the Plan shall not be 
anticipated, assigned, attached, garnished, optioned, transferred or made 
subject to any creditor's process, whether voluntarily, involuntarily or by 
operation of law, except as approved by the Committee.  Notwithstanding the 
foregoing, ISOs and, prior to the Company's initial public offering, NSOs may 
not be transferable. However, this Article 16 shall not

                                       A-8


<PAGE>

preclude a Participant from designating a beneficiary who will receive any 
outstanding Awards in the event of the Participant's death, nor shall it 
preclude a transfer of Awards by will or by the laws of descent and 
distribution.

     16.2   TRUSTS.  Neither this Article 16 nor any other provision of the 
Plan shall preclude a Participant from transferring or assigning Restricted 
Shares to (a) the trustee of a trust that is revocable by such Participant 
alone, both at the time of the transfer or assignment and at all times 
thereafter prior to such Participant's death, or (b) the trustee of any other 
trust to the extent approved in advance by the Committee in writing.  A 
transfer or assignment of Restricted Shares from such trustee to any person 
other than such Participant shall be permitted only to the extent approved in 
advance by the Committee in writing, and Restricted Shares held by such 
trustee shall be subject to all of the conditions and restrictions set forth 
in the Plan and in the applicable Stock Award Agreement, as if such trustee 
were a party to such Agreement.

     ARTICLE 17.    FUTURE OF THE PLAN.

     17.1   TERM OF THE PLAN.  The Plan, as set forth herein, was adopted on 
December 5, 1996, and became effective December 1, 1996, except that Articles 
7, 8 and 9 shall not be effective prior to the date of the Company's initial 
public offering.  The Plan shall remain in effect until it is terminated 
under Section 17.2, except that no ISOs shall be granted after November 30, 
2006.

     17.2   AMENDMENT OR TERMINATION.  The Board may, at any time and for any 
reason, amend or terminate the Plan.  An amendment of the Plan shall be 
subject to the approval of the Company's stockholders only to the extent 
required by applicable laws, regulations or rules.  No Awards shall be 
granted under the Plan after the termination thereof.  The termination of the 
Plan, or any amendment thereof, shall not affect any Award previously granted 
under the Plan.

     ARTICLE 18.    DEFINITIONS.

     18.1   "AWARD" means any award of an Option, an SAR, a Restricted Share 
or a Stock Unit under the Plan.

     18.2   "BOARD" means the Company's Board of Directors, as constituted 
from time to time.

     18.3   "CHANGE IN CONTROL" shall mean the occurrence of any of the 
following events:

            (a) The consummation of a merger or consolidation of the Company
     with or into another entity or any other corporate reorganization, if more
     than 50% of the combined voting power of the continuing or surviving
     entity's securities outstanding immediately after such merger,
     consolidation or other reorganization is owned by persons who were not
     stockholders of the Company immediately prior to such merger, consolidation
     or other reorganization;

            (b) A change in the composition of the Board, as a result of which
     fewer than one-half of the incumbent directors are directors who either:

               (A)  Had been directors of the Company 24 months prior to such
            change; or

               (B)  Were elected, or nominated for election, to the Board with
            the affirmative votes of at least a majority of the directors who
            had been directors of the Company 24 months prior to such change and
            who were still in office at the time of the election or nomination;
            or

            (c) Any "person" (as such term is used in sections 13(d) and 14(d)
     of the Exchange Act) by the acquisition or aggregation of securities is or
     becomes the beneficial owner, directly or indirectly, of securities of the
     Company representing 50% or more of the combined voting power of the
     Company's then outstanding securities ordinarily (and apart from rights
     accruing under special circumstances)

                                       A-9


<PAGE>

     having the right to vote at elections of directors (the "Base Capital 
     Stock"); except that any change in the relative beneficial ownership of
     the Company's securities by any person resulting solely from a reduction 
     in the aggregate number of outstanding shares of Base Capital Stock, and 
     any decrease thereafter in such person's ownership of securities, shall be
     disregarded until such person increases in any manner, directly or 
     indirectly, such person's beneficial ownership of any securities of the 
     Company.

The term "Change in Control" shall not include the Company's initial public 
offering or a transaction, the sole purpose of which is to change the state 
of the Company's incorporation.

     18.4   "CODE" means the Internal Revenue Code of 1986, as amended.

     18.5   "COMMITTEE" means a committee of the Board, as described in
Article 2.

     18.6   "COMMON SHARE" means one share of the common stock of the Company.

     18.7   "COMPANY" means Biosite Diagnostics Incorporated, a Delaware
corporation.

     18.8   "EXCHANGE ACT" means the Securities Exchange Act of 1934, as
amended.

     18.9   "EXERCISE PRICE," in the case of an Option, means the amount for 
which one Common Share may be purchased upon exercise of such Option, as 
specified in the applicable Stock Option Agreement.  "Exercise Price," in the 
case of an SAR, means an amount, as specified in the applicable SAR 
Agreement, which is subtracted from the Fair Market Value of one Common Share 
in determining the amount payable upon exercise of such SAR.

     18.10  "FAIR MARKET VALUE" means the market price of Common Shares,
determined by the Committee as follows:

            (a) If the Common Shares were traded over-the-counter on the date in
     question but was not traded on the Nasdaq Stock Market or the Nasdaq
     National Market, then the Fair Market Value shall be equal to the mean
     between the last reported representative bid and asked prices quoted for
     such date by the principal automated inter-dealer quotation system on which
     the Common Shares are quoted or, if the Common Shares are not quoted on any
     such system, by the "Pink Sheets" published by the National Quotation
     Bureau, Inc.;

            (b) If the Common Shares were traded over-the-counter on the date in
     question and were traded on the Nasdaq Stock Market or the Nasdaq National
     Market, then the Fair Market Value shall be equal to the last-transaction
     price quoted for such date by the Nasdaq Stock Market or the Nasdaq
     National Market;

            (c) If the Common Shares were traded on a stock exchange on the date
     in question, then the Fair Market Value shall be equal to the closing price
     reported by the applicable composite transactions report for such date; and

            (d) If none of the foregoing provisions is applicable, then the Fair
     Market Value shall be determined by the Committee in good faith on such
     basis as it deems appropriate.

Whenever possible, the determination of Fair Market Value by the Committee 
shall be based on the prices reported in the Western Edition of THE WALL 
STREET JOURNAL.  Such determination shall be conclusive and binding on all 
persons.

     18.11  "ISO" means an incentive stock option described in section 422(b) of
the Code.


                                       A-10


<PAGE>


     18.12  "KEY EMPLOYEE" means (a) a common-law employee of the Company, a 
Parent or a Subsidiary, (b) an Outside Director and (c) a consultant or 
adviser who provides services to the Company, a Parent or a Subsidiary as an 
independent contractor.  Service as an Outside Director or as an independent 
contractor shall be considered employment for all purposes of the Plan, 
except as provided in Sections 4.2 and 4.3.

     18.13  "NSO" means a stock option not described in sections 422 or 423 
of the Code.

     18.14  "OPTION" means an ISO or NSO granted under the Plan and entitling 
the holder to purchase one Common Share.

     18.15  "OPTIONEE" means an individual or estate who holds an Option or 
SAR.

     18.16  "OUTSIDE DIRECTOR" shall mean a member of the Board who is not a 
common-law employee of the Company, a Parent or a Subsidiary.

     18.17  "PARENT" means any corporation (other than the Company) in an 
unbroken chain of corporations ending with the Company, if each of the 
corporations other than the Company owns stock possessing 50% or more of the 
total combined voting power of all classes of stock in one of the other 
corporations in such chain.  A corporation that attains the status of a 
Parent on a date after the adoption of the Plan shall be considered a Parent 
commencing as of such date.

     18.18  "PARTICIPANT" means an individual or estate who holds an Award.

     18.19  "PLAN" means this 1996 Stock Incentive Plan of Biosite 
Diagnostics Incorporated, as amended from time to time.

     18.20  "RESTRICTED SHARE" means a Common Share awarded under the Plan.

     18.21  "SAR" means a stock appreciation right granted under the Plan.

     18.22  "SAR AGREEMENT" means the agreement between the Company and an 
Optionee which contains the terms, conditions and restrictions pertaining to 
his or her SAR.

     18.23  "STOCK AWARD AGREEMENT" means the agreement between the Company 
and the recipient of a Restricted Share or Stock Unit which contains the 
terms, conditions and restrictions pertaining to such Restricted Share or 
Stock Unit.

     18.24  "STOCK OPTION AGREEMENT" means the agreement between the Company 
and an Optionee which contains the terms, conditions and restrictions 
pertaining to his or her Option.

     18.25  "STOCK UNIT" means a bookkeeping entry representing the 
equivalent of one Common Share, as awarded under the Plan.

     18.26  "SUBSIDIARY" means any corporation (other than the Company) in an 
unbroken chain of corporations beginning with the Company, if each of the 
corporations other than the last corporation in the unbroken chain owns stock 
possessing 50% or more of the total combined voting power of all classes of 
stock in one of the other corporations in such chain.  A corporation that 
attains the status of a Subsidiary on a date after the adoption of the Plan 
shall be considered a Subsidiary commencing as of such date.


                                       A-11


<PAGE>


     ARTICLE 19.    EXECUTION.

     To record the adoption of the Plan by the Board, the Company has caused 
its duly authorized officer to affix the corporate name and seal hereto.

                                         BIOSITE DIAGNOSTICS INCORPORATED



                                         By _____________________________


                                       A-12


<PAGE>

                                                                     EXHIBIT B



                           BIOSITE DIAGNOSTICS INCORPORATED

                                 AMENDED AND RESTATED

                             EMPLOYEE STOCK PURCHASE PLAN


SECTION 1.  PURPOSE OF THE PLAN.

     The Plan was adopted by the Company's Board of Directors on December 5, 
1996.  On February 27, 1998, the Plan was amended to increase the number of 
shares available under the Plan.

     The purpose of the Plan is to provide Eligible Employees with an 
opportunity to increase their proprietary interest in the success of the 
Company by purchasing Stock from the Company on favorable terms and to pay 
for such purchases through payroll deductions.  The Plan is intended to 
qualify under section 423 of the Internal Revenue Code of 1986, as amended.

SECTION 2.  ADMINISTRATION OF THE PLAN.

     (a) THE COMMITTEE.  The Plan shall be administered by the Committee.  
The interpretation and construction by the Committee of any provision of the 
Plan or of any right to purchase Stock granted under the Plan shall be 
conclusive and binding on all persons.

     (b) RULES AND FORMS.  The Committee may adopt such rules and forms under 
the Plan as it considers appropriate.

SECTION 3.  ENROLLMENT AND PARTICIPATION.

     (a) OFFERING PERIODS.  While the Plan is in effect, two overlapping 
Offering Periods shall commence in each calendar year.  Except for the first 
Offering Period, Offering Periods shall consist of the 24-month periods 
commencing on each January 1 and July 1.  The first Offering Period shall 
commence on the effective date of the Company's initial public offering and 
end on December 31, 1998.

     (b) ACCUMULATION PERIODS.  While the Plan is in effect, two Accumulation 
Periods shall commence in each calendar year.  Except for the first 
Accumulation Period, Accumulation Periods shall consist of the six-month 
periods commencing on each January 1 and July 1.  The first Accumulation 
Period shall commence on the effective date of the Company's initial public 
offering and end on June 30, 1997.

     (c) ENROLLMENT.  Any individual who, on the day preceding the first day 
of an Offering Period, qualifies as an Eligible Employee may elect to become 
a Participant in the Plan for such Offering Period by executing the 
enrollment form prescribed for this purpose by the Committee.  The enrollment 
form shall be filed with the Company not later than one week prior to the 
last working day prior to the commencement of such Offering Period.

     (d) DURATION OF PARTICIPATION.  Once enrolled in the Plan, a Participant 
shall continue to participate until he or she ceases to be an Eligible 
Employee, withdraws from the Plan or reaches the end of the Accumulation 
Period in which he or she discontinued contributions.  A Participant who 
discontinued contributions under Section 4(d) or withdrew from the Plan under 
Section 5(a) may again become a Participant, if he or she then is an Eligible 
Employee, by following the procedure described in Subsection (c) above.


                                       B-1


<PAGE>


     (e) APPLICABLE OFFERING PERIOD.  For purposes of calculating the 
Purchase Price under Section 7(b), the applicable Offering Period shall be 
determined as follows:

            (i) Once a Participant is enrolled in the Plan for an Offering
     Period, such Offering Period shall continue to apply to him or her until
     the earliest of (A) the end of such Offering Period, (B) the end of his or
     her participation under Subsection (d) above or (C) reenrollment in a
     subsequent Offering Period under Paragraph (ii) below.

            (ii) In the event that the Fair Market Value of Stock on the last
     trading day before the commencement of the Offering Period in which the
     Participant is enrolled is higher than on the last trading day before the
     commencement of any subsequent Offering Period, the Participant shall
     automatically be re-enrolled for such subsequent Offering Period.

            (iii) When a Participant reaches the end of an Offering Period but
     his or her participation is to continue, then such Participant shall
     automatically be re-enrolled for the Offering Period that commences
     immediately after the end of the prior Offering Period.

SECTION 4.  EMPLOYEE CONTRIBUTIONS.

     (a) FREQUENCY OF PAYROLL DEDUCTIONS.  A Participant may purchase shares 
of Stock under the Plan solely by means of payroll deductions.  Payroll 
deductions, as designated by the Participant pursuant to Subsection (b) 
below, shall occur on each payday during participation in the Plan.

     (b) AMOUNT OF PAYROLL DEDUCTIONS.  An Eligible Employee shall designate 
on the enrollment form the portion of his or her Compensation that he or she 
elects to have withheld for the purchase of Stock.  Such portion shall be a 
whole percentage of the Eligible Employee's Compensation, but not less than 
1% nor more than 15%.

     (c) CHANGING WITHHOLDING RATE.  If a Participant wishes to change the 
rate of payroll withholding, he or she may do so by filing a new enrollment 
form with the Company not later than one week prior to the last working day 
prior to the commencement of the Accumulation Period for which such change is 
to be effective.

     (d) DISCONTINUING PAYROLL DEDUCTIONS.  If a Participant wishes to 
discontinue employee contributions entirely, he or she may do so by filing a 
new enrollment form at any time.  Payroll withholding shall cease as soon as 
reasonably practicable after such form has been received by the Company.

SECTION 5.  WITHDRAWAL FROM THE PLAN.

     (a) WITHDRAWAL.  A Participant may elect to withdraw from the Plan by 
filing the prescribed form with the Company at any time before the last day 
of an Accumulation Period.  As soon as reasonably practicable thereafter, 
payroll deductions shall cease and the entire amount credited to the 
Participant's Plan Account shall be refunded to him or her in cash, without 
interest.  No partial withdrawals shall be permitted.

     (b) RE-ENROLLMENT AFTER WITHDRAWAL.  A former Participant who has 
withdrawn from the Plan shall not be a Participant until he or she re-enrolls 
in the Plan under Section 3(b).

SECTION 6.  TERMINATION OF EMPLOYMENT OR DEATH.

     (a) TERMINATION OF EMPLOYMENT.  Termination of employment as an Eligible 
Employee for any reason, including death, shall be treated as an automatic 
withdrawal from the Plan under Section 5(a).  (A transfer from one 
Participating Company to another shall not be treated as a termination of 
employment.)

     (b) DEATH.  In the event of the Participant's death, the amount credited 
to his or her Plan Account shall be paid to a beneficiary designated by him 
or her for this purpose on the prescribed form or, if none, to the 

                                       B-2


<PAGE>


Participant's estate.  Such form shall be valid only if it was filed with the 
Company before the Participant's death.

SECTION 7.  PLAN ACCOUNTS AND PURCHASE OF SHARES.

     (a) PLAN ACCOUNTS.  The Company shall maintain a Plan Account on its 
books in the name of each Participant.  Whenever an amount is deducted from 
the Participant's Compensation under the Plan, such amount shall be credited 
to the Participant's Plan Account.  No interest shall be credited to Plan 
Accounts.

     (b) PURCHASE PRICE.  The Purchase Price for each share of Stock 
purchased at the close of an Accumulation Period shall be the lower of:

            (i)  85% of the Fair Market Value of such share on the last trading
     day before the commencement of the applicable Offering Period (as
     determined under Section 3(e)); or

            (ii)  85% of the Fair Market Value of such share on the last trading
     day in such Accumulation Period.

     (c) NUMBER OF SHARES PURCHASED.  As of the last day of each Accumulation 
Period, each Participant shall be deemed to have elected to purchase the 
number of shares of Stock calculated in accordance with this Subsection (c), 
unless the Participant has previously elected to withdraw from the Plan in 
accordance with Section 5(a).  The amount then in the Participant's Plan 
Account shall be divided by the Purchase Price, and the number of shares that 
results shall be purchased from the Company with the funds in the 
Participant's Plan Account. The foregoing notwithstanding, no Participant 
shall purchase more than a maximum of 2,500 shares of Stock with respect to 
any Accumulation Period nor shares of Stock in excess of the amounts set 
forth in Sections 8 and 12(a).  The Committee may determine with respect to 
all Participants that any fractional share, as calculated under this 
Subsection (c), shall be rounded down to the next lower whole share.

     (d) AVAILABLE SHARES INSUFFICIENT.  In the event that as of the 
beginning of an Accumulation Period the Committee determines that the 
aggregate number of shares that all Participants are projected or are likely 
to elect during an Accumulation Period exceeds the maximum number of shares 
remaining available for issuance under Section 12(a), including in connection 
with an Offering Period beginning prior to the date of the Accumulation 
Period with insufficient shares, then the Committee may either determine that 
such shares shall not be made in connection with any previous Offering Period 
but shall be added to any new increase in the shares available under the Plan 
in a new Offering Period starting on the date of the Accumulation Period with 
insufficient shares, or the number of shares to which each Participant is 
entitled in any Offering Period shall be determined by multiplying the number 
of Shares available for issuance by a fraction, the numerator of which is the 
number of shares that such Participant has elected to purchase and the 
denominator of which is the number of shares that all Participants have 
elected to purchase.  In the event the Committee does not make any 
determination, the default method for dealing with insufficient shares in an 
Accumulation Period shall be the fractional method described in the preceding 
sentence.

     (e) ISSUANCE OF STOCK.  Certificates representing the shares of Stock 
purchased by a Participant under the Plan shall be issued to him or her as 
soon as reasonably practicable after the close of the applicable Accumulation 
Period, except that the Committee may determine that such shares shall be 
held for each Participant's benefit by a broker designated by the Committee 
(unless the Participant has elected that certificates be issued to him or 
her).  Shares may be registered in the name of the Participant or jointly in 
the name of the Participant and his or her spouse as joint tenants with right 
of survivorship or as community property.

     (f) UNUSED CASH BALANCES.  An amount remaining in the Participant's Plan 
Account that represents the Purchase Price for any fractional share shall be 
carried over in the Participant's Plan Account to the next Accumulation 
Period. Any amount remaining in the Participant's Plan Account that 
represents the Purchase
                                       B-3


<PAGE>


Price for whole shares that could not be purchased by reason of Subsection 
(c) above or Section 12(a) shall be refunded to the Participant in cash, 
without interest.

     (g) FAILURE OF SHAREHOLDERS TO APPROVE PLAN.  In the event shareholders 
of the Company do not approve this Plan, the Participant's Plan Account shall 
be repaid to the Participant in cash and no Company shares will be purchased 
for the Participant under this Plan.

SECTION 8.  LIMITATIONS ON STOCK OWNERSHIP.

     Any other provision of the Plan notwithstanding, no Participant shall be 
granted a right to purchase Stock under the Plan if:

            (a)  Such Participant, immediately after his or her election to
     purchase such Stock, would own stock possessing more than 5% of the total
     combined voting power or value of all classes of stock of the Company or
     any parent or Subsidiary of the Company; or

            (b)  Under the terms of the Plan, such Participant's rights to
     purchase stock under this and all other qualified employee stock purchase
     plans of the Company or any parent or Subsidiary of the Company would
     accrue at a rate that exceeds $25,000 of the fair market value of such
     stock (determined at the time when such right is granted) for each calendar
     year for which such right or option is outstanding at any time.

Ownership of stock shall be determined after applying the attribution rules 
of section 424(d) of the Internal Revenue Code of 1986, as amended.  For 
purposes of this Section 8, each Participant shall be considered to own any 
stock that he or she has a right or option to purchase under this or any 
other plan, and each Participant shall be considered to have the right to 
purchase 2,500 shares of Stock under this Plan with respect to each 
Accumulation Period.

SECTION 9.  RIGHTS NOT TRANSFERABLE.

     The rights of any Participant under the Plan, or any Participant's 
interest in any Stock or moneys to which he or she may be entitled under the 
Plan, shall not be transferable by voluntary or involuntary assignment or by 
operation of law, or in any other manner other than by beneficiary 
designation or the laws of descent and distribution.  If a Participant in any 
manner attempts to transfer, assign or otherwise encumber his or her rights 
or interest under the Plan, other than by beneficiary designation or the laws 
of descent and distribution, then such act shall be treated as an election by 
the Participant to withdraw from the Plan under Section 5(a).

SECTION 10.  NO RIGHTS AS AN EMPLOYEE.

     Nothing in the Plan shall be construed to give any person the right to 
remain in the employ of a Participating Company.  Each Participating Company 
reserves the right to terminate the employment of any person at any time, 
with or without cause.

SECTION 11.  NO RIGHTS AS A STOCKHOLDER.

     A Participant shall have no rights as a stockholder with respect to any 
shares that he or she has purchased, or may have a right to purchase, under 
the Plan until the date of issuance of a stock certificate for such shares.

SECTION 12.  STOCK OFFERED UNDER THE PLAN.

     (a) AUTHORIZED SHARES.  The aggregate number of shares of Stock 
available for purchase under the Plan shall be 350,000, subject to adjustment 
pursuant to this Section 12.


                                       B-4


<PAGE>


     (b) ANTI-DILUTION ADJUSTMENTS.  The aggregate number of shares of Stock 
offered under the Plan, the 2,500-share limitation described in Section 7(c) 
and the price of shares that any Participant has elected to purchase shall be 
adjusted proportionately by the Committee for any increase or decrease in the 
number of outstanding shares of Stock resulting from a subdivision or 
consolidation of shares, the payment of a stock dividend, any other increase 
or decrease in such shares effected without receipt or payment of 
consideration by the Company or the distribution of the shares of a 
Subsidiary to the Company's stockholders.

     (c) REORGANIZATIONS.  In the event of a dissolution or liquidation of 
the Company, or a merger or consolidation to which the Company is a 
constituent corporation, the Plan shall terminate unless the plan of merger, 
consolidation or reorganization provides otherwise, and all amounts that have 
been withheld but not yet applied to purchase Stock hereunder shall be 
refunded, without interest.  The Plan shall in no event be construed to 
restrict in any way the Company's right to undertake a dissolution, 
liquidation, merger, consolidation or other reorganization.

SECTION 13.  AMENDMENT OR DISCONTINUANCE.

     The Board of Directors shall have the right to amend, suspend or 
terminate the Plan at any time and without notice.  Except as provided in 
Section 12, any increase in the aggregate number of shares of Stock to be 
issued under the Plan shall be subject to approval by a vote of the 
stockholders of the Company.  In addition, any other amendment of the Plan 
shall be subject to approval by a vote of the stockholders of the Company to 
the extent required by an applicable law or regulation.

SECTION 14.  DEFINITIONS.

     (a) "ACCUMULATION PERIOD" means a six-month period during which 
contributions may be made toward the purchase of Stock under the Plan, as 
determined pursuant to Section 3(b).

     (b) "BOARD OF DIRECTORS" means the Board of Directors of the Company, as 
constituted from time to time.

     (c) "COMMITTEE" means a committee of the Board of Directors, consisting 
of one or more directors appointed by the Board of Directors.

     (d) "COMPANY" means Biosite Diagnostics Incorporated, a Delaware 
corporation.

     (e) "COMPENSATION" means the total compensation paid in cash to a 
Participant by a Participating Company, including salaries, wages, overtime 
pay and commissions, but excluding bonuses, incentive compensation, moving or 
relocation allowances, car allowances, imputed income attributable to cars or 
life insurance, taxable fringe benefits and similar items, all as determined 
by the Committee.

     (f) "ELIGIBLE EMPLOYEE" means any employee of a Participating Company:

            (i)  Whose customary employment is for more than five months per
     calendar year and for more than 20 hours per week; and

            (ii)  Who has been an employee of a Participating Company for not
     less than one month.

     (g) "FAIR MARKET VALUE" shall mean the market price of Stock, determined by
the Committee as follows:

            (i) If Stock was traded over-the-counter on the date in question but
     was not traded on the Nasdaq Stock Market or the Nasdaq National Market,
     then the Fair Market Value shall be equal to the mean between the last
     reported representative bid and asked prices quoted for such date by the
     principal


                                       B-5


<PAGE>


     automated inter-dealer quotation system on which Stock is quoted or, if
     the Stock is not quoted on any such system, by the "Pink Sheets" published
     by the National Quotation Bureau, Inc.;

            (ii) If Stock was traded over-the-counter on the date in question
     and was traded on the Nasdaq Stock Market or the Nasdaq National Market,
     then the Fair Market Value shall be equal to the last-transaction price
     quoted for such date by the Nasdaq Stock Market or the Nasdaq National
     Market;

            (iii) If the Stock was traded on a stock exchange on the date in
     question, then the Fair Market Value shall be equal to the closing price
     reported by the applicable composite transactions report for such date; and

            (iv) If none of the foregoing provisions is applicable, then the
     Fair Market Value shall be determined by the Committee in good faith on
     such basis as it deems appropriate.

Whenever possible, the determination of Fair Market Value by the Committee 
shall be based on the prices reported in the Western Edition of THE WALL 
STREET JOURNAL or as reported directly to the Company by Nasdaq or a 
comparable exchange.  Such determination shall be conclusive and binding on 
all persons.

     (h) "OFFERING PERIOD" means a 24-month period with respect to which the 
right to purchase Stock may be granted under the Plan, as determined pursuant 
to Section 3(a).

     (i) "PARTICIPANT" means an Eligible Employee who elects to participate 
in the Plan, as provided in Section 3(c).

     (j) "PARTICIPATING COMPANY" means the Company and each present or future 
Subsidiary, except Subsidiaries excluded by the Committee.

     (k) "PLAN" means this Biosite Diagnostics Incorporated Employee Stock 
Purchase Plan, as amended from time to time.

     (l) "PLAN ACCOUNT" means the account established for each Participant 
pursuant to Section 6(a).

     (m) "PURCHASE PRICE" means the price at which Participants may purchase 
Stock under the Plan, as determined pursuant to Section 7(b).

     (n) "STOCK" means the Common Stock of the Company.

     (o) "SUBSIDIARY" means a corporation, 50% or more of the total combined 
voting power of all classes of stock of which is owned by the Company or by 
another Subsidiary.

SECTION 15.  EXECUTION.

     To record the adoption of the Plan by the Board of Directors, the Company
has caused its duly authorized officer to affix the corporate name and seal
hereto.


                                            BIOSITE DIAGNOSTICS INCORPORATED



                                            By: _____________________________



                                       B-6


<PAGE>


                           BIOSITE DIAGNOSTICS INCORPORATED
                 PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                         FOR ANNUAL MEETING ON MAY 21, 1998.

     Timothy J. Wollaeger and Kim D. Blickenstaff, or each of them, each with 
the power of substitution, are hereby authorized to represent as proxies and 
vote all shares of stock of Biosite Diagnostics Incorporated (the "Company") 
the undersigned is entitled to vote at the Annual Meeting of Stockholders of 
the Company to be held at the Doubletree Hotel, 11915 El Camino Real, Del 
Mar, California on Thursday, May 21, 1998 at 9:00 a.m. or at any postponement 
or adjournment thereof, and instructs said proxies to vote as follows:

Shares represented by this proxy will be voted as directed by the 
stockholder. IF NO SUCH DIRECTIONS ARE INDICATED, THE PROXIES WILL HAVE 
AUTHORITY TO VOTE FOR THE ELECTION OF THE TWO NOMINEES FOR CLASS I DIRECTOR 
AND FOR ITEMS 2, 3 AND 4.

                     (continued and to be signed on reverse side)
- -------------------------------------------------------------------------------

                                 FOLD AND DETACH HERE


<PAGE>

    THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE ELECTION OF THE TWO 
NOMINEES FOR CLASS I DIRECTOR AND FOR ITEMS 2, 3 AND 4.

                      Please mark your votes as indicated in this example   /X/

                              FOR                       WITHHOLD
                      all nominees listed               AUTHORITY
                      below (except as                to vote for all
                    marked to the contrary)       nominees listed below

1.   ELECTION OF DIRECTORS 
     Nominee: Lonnie M. Smith
              Timothy J. Wollaeger

(INSTRUCTION:  To withhold authority to vote for
any individual nominee, write that nominee's name
in the space provided below.)

- ---------------------------------------------------


2.   To approve the amendment of the                   FOR   AGAINST    ABSTAIN
       Stock Incentive Plan:

3.   To approve the amendment of the ESPP:             FOR    AGAINST   ABSTAIN

4.   To ratify the appointment of Ernst & Young LLP    FOR    AGAINST   ABSTAIN
       as the Company's independent auditors:

5.   In their discretion, upon such other business 
       as may properly come before the meeting:        FOR    AGAINST   ABSTAIN



                            /  PLEASE MARK, SIGN, DATE AND MAIL THIS PROXY CARD
                            /  PROMPTLY, USING THE ENCLOSED ENVELOPE.


Signature(s)______________________________    Dated: ____________________, 1998

Please sign exactly as your name or name(s) appear on this proxy.  When 
signing as attorney, executor, administrator, trustee or guardian, please 
give full title as such.  If shares are held jointly, each holder should sign.

- --------------------------------------------------------------------------------

                                 FOLD AND DETACH HERE


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