PROGENICS PHARMACEUTICALS INC
SC 13G, 1998-02-13
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G


                   UNDER THE SECURITIES EXCHANGE ACT OF 1934
                           (Amendment No.          )*
                                          ---------


                        PROGENICS PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
                               (Name of Issuer)



                                  COMMON STOCK
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)



                                   743187106
- --------------------------------------------------------------------------------
                                 (CUSIP Number)



     * The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.


     The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).

                                     Page 1
<PAGE>
 
CUSIP No.  743187106
           ---------
- --------------------------------------------------------------------------------

     1) Names of Reporting Person

        S.S. or I.R.S. Identification No. of Above Person

           Tudor Investment Corporation
        
           22-2514825
        
- --------------------------------------------------------------------------------

     2) Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)
        
        (b)       X
        
- --------------------------------------------------------------------------------

     3) SEC Use Only
        
- --------------------------------------------------------------------------------

     4) Citizenship or Place of Organization   Delaware

- --------------------------------------------------------------------------------

                   (5) Sole Voting Power                 0
Number of Shares   -------------------------------------------------------------
Beneficially       (6) Shared Voting Power       2,135,165
Owned by Each      -------------------------------------------------------------
Reporting Person   (7) Sole Dispositive Power            0
With               -------------------------------------------------------------
                   (8) Shared Dispositive Power  2,135,165

- --------------------------------------------------------------------------------

     9) Aggregate Amount Beneficially Owned by Each Reporting Person   2,135,165

- --------------------------------------------------------------------------------

    10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)
                            
- --------------------------------------------------------------------------------

    11) Percent of Class Represented by Amount in Row 9   23.7%

- --------------------------------------------------------------------------------

    12) Type of Reporting Person (See Instructions)   CO

- --------------------------------------------------------------------------------

                                     Page 2
<PAGE>
 
CUSIP No.  743187106
           ---------
- --------------------------------------------------------------------------------

     1) Names of Reporting Person

        S.S. or I.R.S. Identification No. of Above Person

           Tudor Group Holdings LLC
        
           13-3862746

- --------------------------------------------------------------------------------

     2) Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)


        (b)       X

- --------------------------------------------------------------------------------

     3) SEC Use Only

- --------------------------------------------------------------------------------

     4) Citizenship or Place of Organization   Delaware

- --------------------------------------------------------------------------------

                   (5) Sole Voting Power               0
Number of Shares   -------------------------------------------------------------
Beneficially       (6) Shared Voting Power       249,149
Owned by Each      -------------------------------------------------------------
Reporting Person   (7) Sole Dispositive Power          0                        
With               -------------------------------------------------------------
                   (8) Shared Dispositive Power  249,149                        
                                                                                
- --------------------------------------------------------------------------------

     9) Aggregate Amount Beneficially Owned by Each Reporting Person   249,149

- --------------------------------------------------------------------------------

    10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)

- --------------------------------------------------------------------------------

    11) Percent of Class Represented by Amount in Row 9   2.8%

- --------------------------------------------------------------------------------

    12) Type of Reporting Person (See Instructions)   OO

- --------------------------------------------------------------------------------

                                     Page 3
<PAGE>
 
CUSIP No.  743187106
           ---------
- --------------------------------------------------------------------------------

     1) Names of Reporting Person

        S.S. or I.R.S. Identification No. of Above Person

           Paul Tudor Jones, II

- --------------------------------------------------------------------------------

     2) Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)

        (b)       X

- --------------------------------------------------------------------------------

     3) SEC Use Only

- --------------------------------------------------------------------------------

     4) Citizenship or Place of Organization   USA

- --------------------------------------------------------------------------------

                   (5) Sole Voting Power           488,625
Number of Shares   -------------------------------------------------------------
Beneficially       (6) Shared Voting Power       2,384,314      
Owned by Each      -------------------------------------------------------------
Reporting Person   (7) Sole Dispositive Power      488,625   
With               -------------------------------------------------------------
                   (8) Shared Dispositive Power  2,384,314  

- --------------------------------------------------------------------------------
                   
     9) Aggregate Amount Beneficially Owned by Each Reporting Person   2,872,939

- --------------------------------------------------------------------------------

    10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)

- --------------------------------------------------------------------------------

    11) Percent of Class Represented by Amount in Row 9   31.9%

- --------------------------------------------------------------------------------

    12) Type of Reporting Person (See Instructions)   IN

- --------------------------------------------------------------------------------

                                     Page 4
<PAGE>
 
CUSIP No.  743187106
           ---------
- --------------------------------------------------------------------------------

     1) Names of Reporting Person

        S.S. or I.R.S. Identification No. of Above Person

           Mark F. Dalton

- --------------------------------------------------------------------------------

     2) Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)

        (b)       X

- --------------------------------------------------------------------------------

     3) SEC Use Only

- --------------------------------------------------------------------------------

     4) Citizenship or Place of Organization   USA

- --------------------------------------------------------------------------------

                   (5) Sole Voting Power            48,000
Number of Shares   -------------------------------------------------------------
Beneficially       (6) Shared Voting Power       2,384,314
Owned by Each      -------------------------------------------------------------
Reporting Person   (7) Sole Dispositive Power       48,000
With               -------------------------------------------------------------
                   (8) Shared Dispositive Power  2,384,314  

- --------------------------------------------------------------------------------

     9) Aggregate Amount Beneficially Owned by Each Reporting Person   2,432,314

- --------------------------------------------------------------------------------

    10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)

- --------------------------------------------------------------------------------

    11) Percent of Class Represented by Amount in Row 9   27.0%

- --------------------------------------------------------------------------------

    12) Type of Reporting Person (See Instructions)   IN

- --------------------------------------------------------------------------------

                                     Page 5
<PAGE>
 
CUSIP No.  743187106
           ---------
- --------------------------------------------------------------------------------

     1) Names of Reporting Person

        S.S. or I.R.S. Identification No. of Above Person

           Tudor BVI Futures, Ltd.

- --------------------------------------------------------------------------------

     2) Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)

        (b)       X

- --------------------------------------------------------------------------------

     3) SEC Use Only

- --------------------------------------------------------------------------------

     4) Citizenship or Place of Organization   British Virgin Islands

- --------------------------------------------------------------------------------

                   (5) Sole Voting Power                 0
Number of Shares   -------------------------------------------------------------
Beneficially       (6) Shared Voting Power       1,847,352
Owned by Each      -------------------------------------------------------------
Reporting Person   (7) Sole Dispositive Power            0
With               -------------------------------------------------------------
                   (8) Shared Dispositive Power  1,847,352  

- --------------------------------------------------------------------------------

     9) Aggregate Amount Beneficially Owned by Each Reporting Person   1,847,352

- --------------------------------------------------------------------------------

    10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)

- --------------------------------------------------------------------------------

    11) Percent of Class Represented by Amount in Row 9   20.5%

- --------------------------------------------------------------------------------

    12) Type of Reporting Person (See Instructions)   CO

- --------------------------------------------------------------------------------

                                     Page 6
<PAGE>
 
CUSIP No.  743187106
           ---------
- --------------------------------------------------------------------------------

     1) Names of Reporting Person

        S.S. or I.R.S. Identification No. of Above Person

           Tudor Arbitrage Partners L.P.

           13-3496979

- --------------------------------------------------------------------------------

     2) Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)

        (b)       X

- --------------------------------------------------------------------------------

     3) SEC Use Only

- --------------------------------------------------------------------------------

     4) Citizenship or Place of Organization   Delaware

- --------------------------------------------------------------------------------

                   (5) Sole Voting Power               0
Number of Shares   -------------------------------------------------------------
Beneficially       (6) Shared Voting Power       205,624                       
Owned by Each      -------------------------------------------------------------
Reporting Person   (7) Sole Dispositive Power          0                       
With               -------------------------------------------------------------
                   (8) Shared Dispositive Power  205,624                        
 
- --------------------------------------------------------------------------------

     9) Aggregate Amount Beneficially Owned by Each Reporting Person     205,624

- --------------------------------------------------------------------------------

    10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)

- --------------------------------------------------------------------------------

    11) Percent of Class Represented by Amount in Row 9    2.3%

- --------------------------------------------------------------------------------

    12) Type of Reporting Person (See Instructions)   PN

- --------------------------------------------------------------------------------

                                     Page 7
<PAGE>
 
CUSIP No.  743187106
           ---------
- --------------------------------------------------------------------------------

     1) Names of Reporting Person

        S.S. or I.R.S. Identification No. of Above Person

           Tudor Proprietary Trading, L.L.C.

           13-3720063

- --------------------------------------------------------------------------------

     2) Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)

        (b)       X

- --------------------------------------------------------------------------------

     3) SEC Use Only

- --------------------------------------------------------------------------------

     4) Citizenship or Place of Organization   Delaware

- --------------------------------------------------------------------------------
 
                   (5) Sole Voting Power              0
Number of Shares   -------------------------------------------------------------
Beneficially       (6) Shared Voting Power       28,125
Owned by Each      -------------------------------------------------------------
Reporting Person   (7) Sole Dispositive Power         0
With               -------------------------------------------------------------
                   (8) Shared Dispositive Power  28,125 
 
- --------------------------------------------------------------------------------

     9) Aggregate Amount Beneficially Owned by Each Reporting Person    28,125

- --------------------------------------------------------------------------------

    10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)

- --------------------------------------------------------------------------------

    11) Percent of Class Represented by Amount in Row 9   0.3%

- --------------------------------------------------------------------------------

    12) Type of Reporting Person (See Instructions)   OO

- --------------------------------------------------------------------------------

                                     Page 8
<PAGE>
 
CUSIP No.  743187106
           ---------
- --------------------------------------------------------------------------------

     1) Names of Reporting Person

        S.S. or I.R.S. Identification No. of Above Person

           Tudor Global Trading LLC

           13-3862744

- --------------------------------------------------------------------------------

     2) Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)

        (b)       X

- --------------------------------------------------------------------------------

     3) SEC Use Only

- --------------------------------------------------------------------------------

     4) Citizenship or Place of Organization   Delaware

- --------------------------------------------------------------------------------

                   (5) Sole Voting Power               0
Number of Shares   -------------------------------------------------------------
Beneficially       (6) Shared Voting Power       221,024
Owned by Each      -------------------------------------------------------------
Reporting Person   (7) Sole Dispositive Power          0
With               -------------------------------------------------------------
                   (8) Shared Dispositive Power  221,024 
 
- --------------------------------------------------------------------------------

     9) Aggregate Amount Beneficially Owned by Each Reporting Person   221,024

- --------------------------------------------------------------------------------

    10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)

- --------------------------------------------------------------------------------

    11) Percent of Class Represented by Amount in Row 9   2.5%

- --------------------------------------------------------------------------------

    12) Type of Reporting Person (See Instructions)   OO

- --------------------------------------------------------------------------------

                                     Page 9
    
<PAGE>
 
ITEM 1(a). Name of Issuer:

           Progenics Pharmaceuticals, Inc.

ITEM 1(b). Address of Issuer's Principal Executive Offices:

           777 Old Saw Mill River Road
           Tarrytown, NY 10591

ITEM 2(a). Name of Person Filing:

           Tudor Investment Corporation ("TIC")      
           Tudor Group Holdings LLC ("TGH")          
           Paul Tudor Jones, II                      
           Mark F. Dalton                            
           Tudor BVI Futures, Ltd. ("Tudor BVI")     
           Tudor Arbitrage Partners L.P. ("TAP")     
           Tudor Proprietary Trading, L.L.C. ("TPT") 
           Tudor Global Trading LLC ("TGT")           
 
ITEM 2(b). Address of Principal Business Office or, if none, Residence:
 
           The principal business office of each of TIC, TGH, TAP, TPT and TGT 
           is:

                   600 Steamboat Road
                   Greenwich, CT 06830

           The principal business office of each of Messrs. Jones and Dalton is:

                   c/o Tudor Investment Corporation
                   600 Steamboat Road
                   Greenwich, CT 06830

           The principal business office of Tudor BVI is:

                   c/o CITCO
                   Kaya Flamboyan 9
                   Curacao, Netherland Antilles

ITEM 2(c). Citizenship:

           TIC is a Delaware corporation
           Tudor BVI is a company organized under the laws of the British Virgin
            Islands
           Messrs. Jones and Dalton are citizens of the United States
           TAP is a Delaware limited partnership
           TGH, TPT and TGT are Delaware limited liability companies

                                    Page 10
<PAGE>
 
ITEM 2(d). Title of Class of Securities:

           Common Stock
 
ITEM 2(e). CUSIP Number:

           743187106


ITEM 3.    If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b),
           check whether the person filing is a:
 
       (a) [  ] Broker or Dealer registered under Section 15 of the Act
       (b) [  ] Bank as defined in section 3(a)(6) of the Act
       (c) [  ] Insurance Company as defined in Section 3(a)(19) of the Act
       (d) [  ] Investment Company registered under Section 8 of the Investment
                Company Act
       (e) [  ] Investment Adviser registered under section 203 of the
                Investment Advisers Act of 1940
       (f) [  ] Employment Benefit Plan, Pension Fund which is subject to the
                provisions of the Employee Retirement Income Security Act of
                1974 or Endowment Fund; see Section 240.13d-1(b)(1)(ii)(F)
       (g) [  ] Parent Holding Company, in accordance with Section 240.13d-
                1(b)(1)(ii)(G) (Note: See Item 7)
       (h) [  ] Group, in accordance with Section 240.13d-1(b)(1)(ii)(H)

                                    Page 11
<PAGE>
 
ITEM 4.  Ownership (as of December 31, 1997).

         (a) Amount Beneficially Owned:  See Item 9 of cover pages

         (b) Percent of Class:  See Item 11 of cover pages

         (c) Number of shares as to which such person has:

             (i)   sole power to vote or to direct the vote See Item 5 of cover
                                                            --------------------
                   pages                                                      
                   -----

             (ii)  shared power to vote or to direct the vote See Item 6 of 
                                                              ------------------
                   cover pages
                   -----------

             (iii) sole power to dispose or to direct the disposition of See 
                                                                         -------
                   Item 7 of cover pages
                   ---------------------

             (iv)  share power to dispose or to direct the disposition of See 
                                                                          ------
                   Item 8 of cover pages
                   ---------------------

     Tudor BVI is the direct beneficial owner of 1,704,501 shares of common
stock ("Shares") and 142,851 warrants ("Warrants" and together with Shares,
"Securities") to purchase Shares.  TAP is the direct beneficial owner of 164,499
Shares and 41,125 Warrants.  TPT is the direct beneficial owner of 22,500 Shares
and 5,625 Warrants.  TGT is the direct beneficial owner of 15,400 Warrants.

     Because TIC provides investment advisory services to Tudor BVI, TIC may be
deemed to beneficially own the Securities owned by Tudor BVI.  TIC expressly
disclaims beneficial ownership of such Securities.  TGH holds a majority of the
equity interests of TGT and indirectly holds a majority of the membership
interests of TPT.  TGH is also the sole limited partner of TPT.  TGH expressly
disclaims beneficial ownership of the Securities beneficially owned by each of
such entities.  TGT, as the sole general partner of TAP may be deemed to
beneficially own the Securities owned by TAP, and Mr. Dalton, as the sole
general partner of D.F. Partners, a New York limited partnership, may be deemed
to beneficially own the Securities owned by such entity.  Each of TGT and Mr.
Dalton expressly disclaim beneficial ownership of such Securities.  Mr. Jones is
the Chairman and principal equity owner of TIC and TGH.  Mr. Jones expressly
disclaims beneficial ownership of the Securities beneficially owned, or deemed
beneficially owned, by such entities.  Mr. Dalton is the President and an equity
owner of TIC and TGH.  Mr. Dalton expressly disclaims beneficial ownership of
the Securities beneficially owned, or deemed beneficially owned, by such
entities.

ITEM 5.  Ownership of Five Percent or Less of a Class.

            Not applicable


ITEM 6.  Ownership of More than Five Percent on Behalf of Another Person.
  
            Not applicable


ITEM 7.  Identification and Classification of the Subsidiary Which Acquired the
         Security Being Reported on By the Parents Holding Company.
  
            Not applicable

                                    Page 12
<PAGE>
 
ITEM 8.  Identification and Classification of Members of the Group.

            See cover pages


ITEM 9.  Notice of Dissolution of Group.


            Not applicable

                                    Page 13
<PAGE>
 
ITEM 10.  Certification.

            Not applicable

            After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and
correct.


                              Dated:  February 13, 1998

                              TUDOR INVESTMENT CORPORATION


                              By: /s/ Andrew S. Paul
                                  --------------------------------------
                                  Andrew S. Paul
                                  Vice President and General Counsel


                                  /s/ Paul Tudor Jones, II
                                  --------------------------------------
                                  Paul Tudor Jones, II


                                  /s/ Mark F. Dalton
                                  --------------------------------------
                                  Mark F. Dalton


                              TUDOR BVI FUTURES, LTD.

                              By: Tudor Investment Corporation,
                                  Trading Advisor

                                  By: /s/ Andrew S. Paul
                                      ----------------------------------
                                      Andrew S. Paul
                                      Vice President and General Counsel

                                    Page 14
<PAGE>
 
                              TUDOR ARBITRAGE PARTNERS L.P.

                              By: Tudor Global Trading LLC,
                                  General Partner

                                  By: /s/ Andrew S. Paul
                                      -------------------------------------
                                      Andrew S. Paul
                                      Vice President and General Counsel


                              TUDOR PROPRIETARY TRADING, L.L.C.

                              By: /s/ Andrew S. Paul
                                  -----------------------------------------
                                  Andrew S. Paul
                                  Vice President and General Counsel


                              TUDOR GLOBAL TRADING LLC

                              By: /s/ Andrew S. Paul
                                  -----------------------------------------
                                  Andrew S. Paul
                                  Vice President and General Counsel

                                    Page 15


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