PROGENICS PHARMACEUTICALS INC
DEF 14A, 1998-04-30
PHARMACEUTICAL PREPARATIONS
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                           SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
                             (Amendment No.     )


Filed by the Registrant  [x]

Filed by a Party other than the Registrant  [ ]

Check the appropriate box:

 [ ] Preliminary Proxy Statement

 [ ] Confidential, for Use of the Commission Only (as permitted by
                    Rule 14a-6(e)(2))

 [x] Definitive Proxy Statement

 [ ] Definitive Additional Materials

 [ ] Soliciting Material Pursuant to Sect. 240.14a-11(c) or Sect. 240.14a-12



                        PROGENICS PHARMACEUTICALS, INC.
               (Name of Registrant as Specified In Its Charter)


    (Name of Person(s) Filing Proxy Statement if other than the Registrant)


Payment of Filing Fee (Check the appropriate box):

 [x] No fee required

 [ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

     1)  Title of each class of securities to which transaction applies:       

     2)  Aggregate number of securities to which transaction applies:        

     3)   Per unit  price or  other underlying  value of  transaction  computed
     pursuant to  Exchange Act  Rule 0-11  (Set forth  the amount  on which the
     filing fee is calculated and state how it was determined):         

     4)  Proposed aggregate value of transaction:         

     5)  Total fee paid:

 [ ] Fee paid previously with preliminary materials.

 [ ] Check box  if any  part of  the fee  is offset as provided by Exchange Act
Rule 0-11(a)(2)  and identify  the filing for which the offsetting fee was paid
previously.   Identify the previous filing by registration statement number, or
the Form or Schedule and the date of its filing.

     1)  Amount Previously Paid:        
     2)  Form, Schedule or Registration Statement No.:        

     3)  Filing Party:          

     4)  Date Filed:          
<PAGE>
                        PROGENICS PHARMACEUTICALS, INC.
                          777 Old Saw Mill River Road
                           Tarrytown, New York 10591


                                                                    May 1, 1998



Dear Stockholder:

          You are  cordially invited  to attend the Company's Annual Meeting of
Stockholders to be held on Tuesday, June 9, 1998 at 1:00 p.m. local time at the
Westchester Marriott Hotel, 670 White Plains Road, Tarrytown, New York.

          At this  meeting, you  will be  asked to  consider and  vote upon the
election of  directors of  the Company,  an amendment  to the Company's Amended
1996 Stock  Incentive Plan,  the adoption  of the Company's 1998 Employee Stock
Purchase Plan  and 1998  Non-Qualified Employee  Stock Purchase  Plan  and  the
ratification of  the Board  of Directors' selection of Coopers & Lybrand L.L.P.
to serve  as the  Company's independent  accountants for the fiscal year ending
December 31, 1998.

          The  Board   of  Directors  appreciates  and  encourages  stockholder
participation in  the Company's affairs and cordially invites you to attend the
meeting in  person.   It  is  in  any  event  important  that  your  shares  be
represented and  we ask  that you sign, date and mail the enclosed proxy in the
envelope provided at your earliest convenience.

          Thank you for your cooperation.

                                   Very truly yours,

                                   PAUL J. MADDON, M.D., PH.D.
                                   Chairman of the Board of Directors
<PAGE>
                        PROGENICS PHARMACEUTICALS, INC.
                          777 Old Saw Mill River Road
                           Tarrytown, New York 10591

                       ________________________________

                   NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                       ________________________________

                                                            Tarrytown, New York
                                                                    May 1, 1998

          NOTICE IS  HEREBY GIVEN  that the  Annual Meeting  of Stockholders of
PROGENICS PHARMACEUTICALS,  INC. (the  "Company"), a Delaware corporation, will
be held  at the  Westchester Marriott  Hotel, 670 White Plains Road, Tarrytown,
New York  on Tuesday, June 9, 1998 at 1:00 p.m. local time, for the purposes of
considering and  voting upon  the following matters, as more fully described in
the attached Proxy Statement:

          1.   To elect  seven directors to serve until the next annual meeting
     of stockholders  and until  their respective  successors are  elected  and
     qualified;

          2.   To approve  and adopt an amendment to the Company's Amended 1996
     Stock Incentive  Plan increasing  the maximum  number  of  shares  of  the
     Company's Common Stock available thereunder for issuance from 1,050,000 to
     2,000,000;

          3.   To approve  and adopt the Company's 1998 Employee Stock Purchase
     Plan providing  for the  issuance of up to 150,000 shares of the Company's
     Common Stock  thereunder and  the Company's  1998  Non-Qualified  Employee
     Stock Purchase  Plan providing  for the issuance of up to 50,000 shares of
     the Company's Common Stock thereunder;

          4.   To ratify the Board of Directors' selection of Coopers & Lybrand
     L.L.P. to  serve as  the Company's  independent accountants for the fiscal
     year ending December 31, 1998; and

          5.   To transact  such other business as may properly come before the
     meeting or any adjournment thereof.

          Only those  stockholders of record at the close of business on May 1,
1998 will  be entitled to receive notice of, and vote at, said meeting.  A list
of stockholders  entitled to  vote at the meeting is open to examination by any
stockholder at  the principal  offices of  the Company,  777 Old Saw Mill River
Road, Tarrytown, New York  10591.

          All stockholders  are cordially  invited to  attend  the  meeting  in
person.   In any  event, please mark your votes, then date, sign and return the
accompanying form  of proxy in the envelope enclosed for that purpose (to which
no postage  need be  affixed if mailed in the United States) whether or not you
expect to attend the meeting in person.  Please note that the accompanying form
of proxy  must be  returned to record your vote.  The proxy is revocable by you
at any  time prior  to its exercise.  The prompt return of the proxy will be of
assistance in  preparing for  the meeting  and your cooperation in this respect
will be appreciated.

                                   By order of the Board of Directors

                                   ROBERT A. MCKINNEY
                                   Secretary
<PAGE>
                        PROGENICS PHARMACEUTICALS, INC.
                          777 Old Saw Mill River Road
                           Tarrytown, New York 10591

                       ________________________________

                                PROXY STATEMENT
                       ________________________________


          This Proxy Statement is furnished to holders of the Common Stock, par
value $.0013 per share (the "Common Stock"), of Progenics Pharmaceuticals, Inc.
(the "Company")  in  connection  with  the  solicitation  of  proxies,  in  the
accompanying form,  by the  Board of  Directors of  the Company, for use at the
Annual Meeting  of Stockholders  to be  held at the Westchester Marriott Hotel,
670 White  Plains Road,  Tarrytown, New  York on Tuesday, June 9, 1998, at 1:00
p.m. local  time, and  at any  and all  adjournments thereof.  Stockholders may
revoke the authority granted by their execution of proxies at any time prior to
their use  by filing  with the Secretary of the Company a written revocation or
duly executed proxy bearing a later date or by attending the meeting and voting
in person.  Solicitation of proxies will be made chiefly through the mails, but
additional solicitation may be made by telephone or telegram by the officers or
regular employees  of the  Company.   The Company  may also  enlist the  aid of
brokerage houses  or the  Company's transfer  agent in soliciting proxies.  All
solicitation expenses,  including costs  of preparing,  assembling and  mailing
proxy material,  will be  borne by  the Company.    This  proxy  statement  and
accompanying form  of proxy are being mailed to stockholders on or about May 1,
1998.

          Shares of  the Common  Stock represented  by executed  and  unrevoked
proxies will  be voted  in accordance with the choice or instructions specified
thereon.   It is  the intention  of the  persons named  in  the  proxy,  unless
otherwise specifically instructed in the proxy, to vote all proxies received by
them FOR  the election of the seven nominees named herein, FOR the approval and
adoption of  the amendment  to the Company's Amended 1996 Stock Incentive Plan,
FOR the  approval and  adoption of  the Company's  1998 Employee Stock Purchase
Plan and  1998 Non-Qualified Employee Stock Option Plan and FOR ratification of
the Board  of Directors'  selection of Coopers & Lybrand L.L.P. to serve as the
Company's independent accountants for the fiscal year ending December 31, 1998.

          If a  quorum is  present at  the meeting,  those nominees receiving a
plurality of  the votes  cast will  be elected as directors.  A majority of the
votes cast  (excluding abstentions  and broker  non-votes) will be required for
the approval  and adoption of the amendment to the Company's Amended 1996 Stock
Incentive Plan,  for the  approval and  adoption of the Company's 1998 Employee
Stock Purchase Plan and 1998 Non-Qualified Employee Stock Purchase Plan and for
the ratification  of the  Board's selection  of Coopers & Lybrand L.L.P. as the
Company's independent accountants.


                                    VOTING

          Only stockholders  of record  at the close of business on May 1, 1997
will be  entitled to  vote at  the meeting or any and all adjournments thereof.
As of  May 1,  1997 the  Company had outstanding 9,003,753 shares of the Common
Stock, the  Company's only  class  of  voting  securities  outstanding.    Each
stockholder of  the Company  will be entitled to one vote for each share of the
Common Stock  registered in  his or her name on the record date.  A majority of
all shares of the Common Stock outstanding constitutes a quorum and is required
to be present in person or by proxy to conduct business at the meeting.

                                      -2-

<PAGE>
                BENEFICIAL OWNERSHIP OF COMMON STOCK BY CERTAIN
                          STOCKHOLDERS AND MANAGEMENT

          The following  table sets  forth certain information, as of April 20,
1998, except  as noted,  regarding the beneficial ownership of the Common Stock
by (i)  each person or group known to the Company to be the beneficial owner of
more than  5% of  the Common  Stock outstanding, (ii) each director and nominee
for director  of the Company, (iii) each executive officer of the Company named
below and  (iv) all directors and executive officers of the Company as a group.
Except as  otherwise specified,  the named beneficial owner has sole voting and
investment power over the shares listed.

                                           Number of Shares               
                                             Beneficially    Percent of
 Name and Address of Beneficial Owner (1)     Owned (2)      Class (2)

 Entities affiliated with Tudor                              
 Investment Corporation (3)............      2,384,314          25.9%
  600 Steamboat Road with
  Greenwich, CT 06830
 Paul Tudor Jones, II (4)..............      2,872,939          31.2%
  600 Steamboat Road
  Greenwich, CT 06830
 Paul J. Maddon, M.D., Ph.D.(5)........      1,425,000          14.7%
 Charles A. Baker (6)..................         48,750            *
 Mark F. Dalton (7)....................      2,432,314          26.4%
 Stephen P. Goff, Ph.D. (8)............         63,750            *
 Elizabeth M Greetham (9)..............        262,500           2.9%
 Paul F. Jacobson (10).................        189,039           2.1%
 David A. Scheinberg, M.D., Ph.D.(11)..        127,868           1.4%
 Robert J. Israel, M.D.(12)............         58,126            *
 Robert A. McKinney (13)...............         65,000            *
 All directors and executive officers                        
  as a group (14)......................      4,672,347          45.6%
_______________________________
*  Less than 1%

(1) Unless otherwise specified, the address of each beneficial owner is c/o the
    Company, 777 Old Saw Mill River Road, Tarrytown, New York 10591.

(2) Except as  indicated and  pursuant to  applicable community  property laws,
    each stockholder possesses sole voting and investment power with respect to
    the shares  of Common  Stock listed.   The number of shares of Common Stock
    beneficially owned  includes the  shares issuable pursuant to stock options
    and warrants  that may  be exercised  within 60  days after April 30, 1998.
    Shares pursuant  to such  options and  warrants are  deemed outstanding for
    computing the percentage of beneficial ownership of the person holding such
    options and  warrants but  are not  deemed outstanding  for  computing  the
    percentage of beneficial ownership of any other person.

(3) The number  of shares  owned by  entities affiliated  with Tudor Investment
    Corporation ("TIC")  consists of  1,704,501 shares  held of record by Tudor
    BVI Futures,  Ltd., an  international business  company organized under the
    law of  the British  Virgin Islands ("Tudor BVI"), 142,851 shares of Common
    Stock issuable  to Tudor  BVI upon  the exercise  of currently  exercisable
    warrants, 287,813  shares held  of record  by TIC,  164,499 shares  held of
    record by  Tudor Arbitrage  Partners L.P.  ("TAP"), 41,125 shares of Common
    Stock issuable  to TAP upon the exercise of currently exercisable warrants,
    22,500 shares  held of record by Tudor Proprietary Trading, L.L.C. ("TPT"),
    5,625 shares of Common Stock issuable to TPT upon the exercise of currently
    exercisable warrants  and 15,400  shares of  Common Stock issuable to Tudor
    Global Trading  LLC ("TGT")  upon the  exercise  of  currently  exercisable
    warrants.   In addition,  because TIC provides investment advisory services
    to Tudor  BVI, it may be deemed to beneficially own the shares held by such
    entity. TIC  disclaims beneficial  ownership of  such shares.   TGT  is the
    general partner  of TAP.  TGT disclaims beneficial ownership of shares held
    by TAP.   The  number set  forth does not include shares owned of record by
    Mr. Jones and Mr. Dalton.  See Notes 4 and 7.

                                      -3-

<PAGE>
(4) Includes 2,384,314  shares beneficially  owned by  entities affiliated with
    TIC.   Mr. Jones  is the  Chairman and  principal stockholder  of TIC,  the
    Chairman and indirect principal equity owner of TGT, the indirect principal
    equity owner of TAP and the Chairman and indirect principal equity owner of
    TPT.   Mr. Jones  may be deemed the beneficial owner of shares beneficially
    owned, or  deemed beneficially owned, by entities affiliated with TIC.  Mr.
    Jones disclaims beneficial ownership of such shares.  See Note 3.

(5) Includes 675,000  shares subject  to stock  options held  by Dr. Maddon and
    exercisable within 60 days of the date hereof.

(6) Includes 3,750  shares of Common Stock issuable to the Baker Family Limited
    Partnership ("BFLP")  upon the  exercise of currently exercisable warrants,
    15,000 shares owned by the BFLP, and 30,000 shares subject to stock options
    held by Mr. Baker and exercisable within 60 days of the date hereof.

(7) Includes 31,500  shares held  of record  directly by  Mr. Dalton and 16,500
    shares of  record held  by DF  Partners, a  family partnership of which Mr.
    Dalton is  the managing  general partner with a 5% interest.  The remaining
    95% partnership  interest is held by trusts for the benefit of Mr. Dalton's
    children.   As to  such  95%  interest,  Mr.  Dalton  disclaims  beneficial
    interest.   The number  set forth  includes 2,384,314  shares  beneficially
    owned by entities affiliated with TIC.  Mr. Dalton is President of TIC, TGT
    and TPT.   Mr. Dalton disclaims beneficial ownership of shares beneficially
    owned, or  deemed beneficially owned, by entities affiliated with TIC.  See
    Note 3.

(8) Includes  26,250   shares  subject  to  stock  options  held  by  Dr.  Goff
    exercisable within 60 days of the date hereof.

(9) Consists of  131,250 shares  held of  record by Weiss, Peck & Greer ("WPG")
    Life Sciences  Fund, L.P.  ("WPGLSF") and  5,625  shares  of  Common  Stock
    issuable to  WPGLSF upon the exercise of currently exercisable warrants and
    116,250 shares  held of  record by  WPG Institutional  Life Sciences  Fund,
    L.P.("WPGILSF") and  9,375 shares  of Common Stock issuable to WPGILSF upon
    the exercise  of currently  exercisable warrants.  Ms. Greetham, who is the
    Portfolio  Manager  for  both  WPGLSF  and  WPGILSF,  disclaims  beneficial
    ownership of  all such  shares except  to  the  extent  of  her  beneficial
    interest in WPGLSF.

(10)Includes 3,750  shares of  Common Stock  issuable to  Mr. Jacobson upon the
    exercise of  currently exercisable  warrants and  27,000 shares  subject to
    stock options  held by  Mr. Jacobson exercisable within 60 days of the date
    hereof.

(11)Includes 938  shares of  Common Stock  issuable to  Dr. Scheinberg upon the
    exercise of  currently exercisable  warrants and  123,180 shares subject to
    stock options held by Dr. Scheinberg exercisable within 60 days of the date
    hereof.

(12)Consists of  58,126 shares  subject to  stock options  held by  Dr.  Israel
    exercisable within 60 days of the date hereof.

(13)Consists of  65,000 shares  subject to  stock options  held by Mr. McKinney
    exercisable within 60 days of the date hereof.

(14)Includes shares held by affiliated entities as set forth in the above table
    and 1,232,995  shares in  the aggregate issuable upon the exercise of stock
    options or  warrants held  by officers  or  directors  or  entities  deemed
    affiliates of certain directors.

                                      -4-

<PAGE>
                      PROPOSAL I:  ELECTION OF DIRECTORS

          At the  meeting, seven  directors (constituting  the entire  Board of
Directors) are  to be  elected to  serve  until  the  next  annual  meeting  of
stockholders and  until their  respective successors are elected and qualified.
The proxies  given pursuant  to this solicitation will be voted in favor of the
seven nominees  listed below  unless authority  is withheld.   Should a nominee
become unavailable  to serve  for any  reason, the proxies will be voted for an
alternative nominee  to be  determined by  the persons named in the proxy.  The
Board of  Directors  has  no  reason  to  believe  that  any  nominee  will  be
unavailable.   Proxies cannot be voted for a greater number of persons than the
number of  nominees named.  The election of directors requires a plurality vote
of those shares voted at the meeting with respect to the election of directors.

Information Concerning Nominees

          The persons  nominated as  directors of  the Company (all of whom are
currently directors  of the  Company), their respective ages, the year in which
each first  became a director of the Company and their principal occupations or
employment during the past five years are as follows:

                                             Year
                                            First
                                           Elected
Name                                Age    Director  Position with the Company

 Paul J. Maddon, M.D., Ph.D........  38      1986    Chairman of the Board of
                                                     Directors, Chief Executive
                                                     Officer, President and
                                                     Chief Science Officer
 Charles A. Baker(1)...............  65      1994    Director
 Mark F. Dalton(1).................  47      1990    Director
 Stephen P. Goff, Ph.D.(2).........  46      1993    Director
 Elizabeth M Greetham(2)...........  48      1994    Director
 Paul F. Jacobson(1)...............  43      1990    Director
 David A. Scheinberg, M.D., Ph.D.(2) 42      1996    Director

(1) Member of Compensation Committee
(2) Member of Audit Committee

     Paul J.  Maddon, M.D.,  Ph.D. is the founder of the Company and has served
in various  capacities since  its inception, including Chairman of the Board of
Directors, Chief  Executive Officer, President and Chief Science Officer.  From
1981 to  1988, Dr.  Maddon performed  research at  the  Howard  Hughes  Medical
Institute at  Columbia University  in the  laboratory of Dr. Richard Axel.  Dr.
Maddon serves  on two  NIH scientific  review committees and is a member of the
editorial board of the Journal of Virology.  He received a B.A. in biochemistry
and mathematics  and  an  M.D.  and  a  Ph.D.  in  biochemistry  and  molecular
biophysics from  Columbia University.  Dr. Maddon has been an Adjunct Assistant
Professor of Medicine at Columbia University since 1989.

     Charles A.  Baker has  been the  Chairman, President  and Chief  Executive
Officer of  The Liposome  Company, Inc.,  a biotechnology  company  located  in
Princeton, NJ,  since 1989.   Mr.  Baker is  currently a  director of Regeneron
Pharmaceuticals, Inc.,  a biotechnology company.  He is a member of the Council
of Visitors  of the  Marine Biological Laboratory at Woods Hole, MA.  Mr. Baker
has more  than 30  years of  pharmaceutical industry  experience, and  has held
senior management positions at Pfizer, Abbott Laboratories, Squibb Corporation,
and A.L. Laboratories.  Mr. Baker received a B.A. from Swarthmore College and a
J.D. from Columbia University.

     Mark F.  Dalton has  been the President and a director of Tudor Investment
Corporation, an  investment advisory  company, and  its affiliates  since 1988.
From 1979  to 1988, he served in various senior management positions at Kidder,
Peabody &  Co. Incorporated,  including Chief Financial Officer.  Mr. Dalton is
currently a  director of several private companies in the U.S., Europe and Asia
as well as a closed-end investment fund traded on the Hong Kong Stock Exchange.
Mr. Dalton  received a  B.A. from Denison University and a J.D. from Vanderbilt
University.

                                      -5-

<PAGE>
     Stephen P.  Goff, Ph.D.  has been  a  member  of  the  Company's  Virology
Scientific Advisory  Board since  1988 and  has been  its Chairman  since April
1991.   Dr.  Goff  has  been  the  Higgins  Professor  in  the  Departments  of
Biochemistry and  Microbiology at  Columbia University  since June  1990.    He
received an A.B. in biophysics from Amherst College and a Ph.D. in biochemistry
from Stanford  University.   Dr. Goff  performed post-doctoral  research at the
Massachusetts Institute of Technology in the laboratory of Dr. David Baltimore.

     Elizabeth M.  Greetham has  been the  Portfolio Manager  for Weiss, Peck &
Greer ("WPG")  Life Sciences  Fund, L.P.  and WPG  Institutional Life  Sciences
Fund, L.P. since 1992 and was a Health Care Analyst at WPG, L.L.C. from 1990 to
1992.   Ms.  Greetham  is  also  a  director  of  Guilford  Pharmaceuticals,  a
biopharmaceutical company,  and ChiRex  Inc. and Pathogenesis Corporation, both
of which  are pharmaceutical  companies.    She  received  an  M.A.  (hons)  in
Economics from Edinburgh University.

     Paul F.  Jacobson, a  private investor,  was a  Managing Director of fixed
income securities  at Deutsche Bank from January 1996 to November 1997.  He was
President of  Jacobson Capital  Partners from 1993 to 1996.  From 1986 to 1993,
Mr. Jacobson  was a  partner at  Goldman, Sachs,  where he  was responsible for
government securities  trading activities.   Mr.  Jacobson received a B.A. from
Vanderbilt University and an M.B.A. from Washington University.

     David A. Scheinberg, M.D., Ph.D. has been a member of the Company's Cancer
Scientific Advisory  Board since 1994.  Dr. Scheinberg has been associated with
Sloan-Kettering since  1986, where  he has  held  the  positions  of  Associate
Professor (since  1994) and Chief (since 1992), Leukemia Service, Member of the
Clinical Immunology  Service (since 1987) and Head, Laboratory of Hematopoietic
Cancer Immunochemistry,  Sloan-Kettering Institute  (since 1989).  He also  has
held  the   position  of   Associate  Professor   of  Medicine   and  Molecular
Pharmacology, Cornell  University Medical  College (since  1994). He received a
B.A. from  Cornell University,  and an  M.D. and  a Ph.D.  in pharmacology  and
experimental therapeutics from The Johns Hopkins University.

Meetings and Committees of the Board of Directors

          During the  fiscal  year  ended  December  31,  1997,  the  Board  of
Directors of  the Company  held six  meetings.  Each of the incumbent directors
except Ms.  Greetham and  Mr. Jacobson  attended more than 75% of the aggregate
number of  meetings held by the Board and the Committees thereof on which he or
she served.

          The Audit  Committee reviews  the annual  financial statements of the
Company prior  to their submission to the Board of Directors, consults with the
Company's independent  auditors, and  examines and considers such other matters
in relation  to the internal and external audit of the Company's account and in
relation to  the financial  affairs of  the Company and its accounts, including
the selection  and retention of independent auditors.  The Audit Committee held
no meetings during the fiscal year ended December 31, 1997.

          The Compensation  Committee makes recommendations concerning salaries
and incentive  compensation for  employees of  and consultants  to the Company,
establishes and approves salaries and incentive compensation for certain senior
officers and employees and administers and grants stock options pursuant to the
Company's stock  option plans.   The  Compensation Committee  met informally by
telephone during  the fiscal  year ended  December 31, 1997  and held no formal
meetings.

          The Company  has no  standing nominating  committee and  no committee
performing a similar function.

Compensation of Directors

          Directors  do   not  receive  compensation  in  their  capacities  as
directors.   All  of  the  directors  are  reimbursed  for  their  expenses  in
connection with their attendance at Board and committee meetings.  In addition,
Dr. Goff  and Dr.  Scheinberg receive  annual compensation  in the  amounts  of
$30,000 and  $24,000, respectively,  for  their  services  as  members  of  the
Company's Virology  Scientific Advisory  Board and  Cancer Scientific  Advisory
Board, respectively.  See also "Certain Transactions."

                                      -6-

<PAGE>
Voting

          Those nominees  receiving a  plurality of  the  votes  cast  will  be
elected directors.   Abstentions  and broker  non-votes  will  not  affect  the
outcome of the election.

          The Board of Directors of the Company deems the election of the seven
nominees listed  above as  directors to  be in the best interest of the Company
and its stockholders and recommends a vote "FOR" their election.


                            EXECUTIVE COMPENSATION

          The following  table sets  forth information  regarding the aggregate
compensation paid  by the  Company for  the two fiscal years ended December 31,
1997 to  the Company's  Chief Executive  Officer and  other executive  officers
whose total compensation exceeded $100,000 during the last fiscal year:


                          SUMMARY COMPENSATION TABLE

                                                             Stock
                            Fiscal Annual Compensation(1)    Option
Name and Principal Position  Year    Salary      Bonus       Grants    Other(2)

Paul J. Maddon, M.D., Ph.D   1997    $250,000  $200,000         -       $1,662
 Chairman of the Board,      1996     165,000    70,000         -        1,662
 Chief Executive Officer,
 President and Chief
 Science Officer

Robert J. Israel, M.D.       1997     185,000    45,000   75,000 shares    -  
 Vice President, Medical     1996     175,000    25,000   18,750 shares    -  
 Affairs

Robert A. McKinney.          1997     105,000    21,000   40,000 shares    -  
 Vice President, Finance     1996     100,000     9,000   15,000 shares    -  
 and Operations and
 Treasurer

_______________________________
(1)Annual compensation  consists  of  base  salary  and  bonus.    As  to  each
   individual named,  the  aggregate  amounts  of  all  perquisites  and  other
   personal benefits,  securities and  property not  included  in  the  summary
   compensation table  above or  described below  do not  exceed the  lesser of
   $50,000 or 10% of the annual compensation.

(2)Other compensation consisted solely of an annual premium paid on a long-term
   disability policy.

     The following  table sets  forth certain  information  relating  to  stock
option grants  to the  executive officers  named above  during the  fiscal year
ended December 31, 1997:

      STOCK OPTION GRANTS DURING THE FISCAL YEAR ENDED DECEMBER 31, 1997
<TABLE>
<CAPTION>
                                        Percent                    Potential Realizable
                                        of Total                     Value at Assumed
                               Number    Option                       Annual Rates of
                             of Shares   Shares    Exercise            Stock Price
                             Underlying Granted     Price   Expir-     Appreciation
                              Options    to Em-      per    ation     for Option Term
 Name                         Granted   Ployees*    Share    Date      5%       10%
<S>                          <C>        <C>        <C>     <C>      <C>       <C>
 Paul J. Maddon, M.D., Ph.D      -         -         -       -         -         -

 Robert J. Israel, M.D.....   75,000     23.8%     $4.00   3/31/07  $188,688  $478,123

 Robert A. McKinney........   40,000     12.7%      4.00   3/31/07  $100,623  $255,000
</TABLE>
_______________________________
* During the  1997 fiscal  year options to purchase 315,375 shares were granted
  to employees.

                                      -7-

<PAGE>
          The following  table sets  forth information  as to  the exercises of
options during the fiscal year ended December 31, 1997 and the number and value
of unexercised  options held  by the  executive  officers  named  above  as  of
December 31, 1997:

                            YEAR-END OPTION VALUES
<TABLE>
<CAPTION>
                                      Number of
                                  Shares Underlying         Value of Unexercised
                                 Unexercised Options       In-the-Money Options*
Name                         Exercisable  Unexercisable  Exercisable  Unexercisable
<S>                          <C>          <C>            <C>          <C>
Paul J. Maddon, M.D., Ph.D.    375,000       375,000      $3,205,228    $3,251,250

Robert J. Israel, M.D.....      38,438       111,562      $  384,380    $1,115,620

Robert A. McKinney........      53,250        54,250      $  544,875    $  542,500
</TABLE>
_______________________________
* Based on a closing price of $14.00 on December 31, 1997 on the Nasdaq
  National Market.

Employment Agreements

          The Company  has entered  into an  employment agreement  with Paul J.
Maddon, M.D., Ph.D. pursuant to which Dr. Maddon is to serve as Chairman of the
Board, President,  Chief Executive  Officer and  Chief Science  Officer of  the
Company at  an annual  salary of $250,000 for 1998 to increase at a rate of 10%
per year  and a  guaranteed minimum  bonus of  $15,000 per year.  The agreement
expires on  December  15,  1998,  but  it  is  automatically  renewed  annually
thereafter for up to five successive one-year periods unless either the Company
or Dr.  Maddon gives notice not to renew at least 90 days before the end of the
initial term  or any  renewal term.   Under  the agreement, Dr. Maddon was also
granted an  option to  purchase 750,000  shares of the Common Stock at exercise
prices of  $5.33 per  share with  respect to 664,774 shares and $5.87 per share
with respect  to 85,226  shares.  The agreement provides that, upon termination
by the  Company without  cause (as  defined in the agreement), the Company will
continue to pay Dr. Maddon's annual salary and minimum bonus through the end of
the then current term.

          The Company  has in  effect an  employment arrangement with Robert J.
Israel, M.D.  pursuant to  which Dr.  Israel is  to serve  as  Vice  President,
Medical Affairs  of the Company at an annual salary of $185,000 and is entitled
to nine  months' salary  if his employment is terminated by the Company without
cause.

                                      -8-

<PAGE>
Compensation Committee Report on Executive Compensation

          The Compensation  Committee's policies applicable to the compensation
of the  Company's executive  officers are  based on  the principle  that  total
compensation should  be set  to attract and retain those executives critical to
the overall  success of  the Company  and should  reward executives  for  their
contributions to the enhancement of shareholder value.

          The key  elements of  the executive  compensation  package  are  base
salary, employee  benefits applicable  to all  employees, an  annual bonus  and
long-term incentive compensation in the form of stock options.  In general, the
Compensation Committee  has adopted  the policy that compensation for executive
officers  should  be  competitive  with  that  paid  by  leading  biotechnology
companies for corresponding senior executives.  The Compensation Committee also
believes that  it is  important to  have stock options constitute a substantial
portion of  executive compensation  in order  to help  executives  align  their
interests with those of the stockholders.

          In determining  the compensation  for  each  executive  officer,  the
Compensation Committee  generally considers  (i) data  from outside studies and
proxy materials  regarding compensation  of executive  officers  at  comparable
companies, (ii)  the input  of other directors regarding individual performance
of each executive officer and (iii) qualitative measures of Company performance
such as progress in the development of the Company's technology, the engagement
of corporate  partners for the commercial development and marketing of products
and the  success of  the Company  in raising  the funds  necessary  to  conduct
research and  development.   The Compensation Committee's consideration of such
factors is subjective and informal.

          The compensation  of Paul  J. Maddon,  the Chief Executive Officer of
the Company,  for 1997  consisted of  $250,000 in annual salary and $200,000 in
bonuses.   In approving  the bonuses  and the  increase in  Dr. Maddon's annual
salary from  $165,000 to  $250,000, the  Compensation Committee  considered the
importance of  the collaboration  agreement with  Bristol-Myers Squibb  Company
entered into  in 1997  and the success of the Company's initial public offering
in November  of 1997  and concluded  that Dr.  Maddon's leadership  contributed
significantly to  the Company's  achievements and progress in the past and that
Dr. Maddon  will continue  to make  significant contributions  to the Company's
performance in the future.

                                 Compensation Committee of the
                                      Board of Directors

                                      Charles A. Baker
                                      Mark F. Dalton
                                      Paul F. Jacobson


Comparative Stock Performance Graph

          The graph  below compares  the cumulative total stockholder return on
the Company's  Common Stock with the cumulative total stockholder return of (i)
the Nasdaq  Stock Market (U.S.) Index and (ii) the Nasdaq Pharmaceutical Index,
assuming an  investment of $100 on November 19, 1997, the date of the Company's
initial public  offering, in  each of  the Company's  Common Stock,  the stocks
comprising the  Nasdaq Market  Index  and  the  stocks  comprising  the  Nasdaq
Pharmaceutical Index.

                         Progenics   Nasdaq Market  Nasdaq Pharm.
              11/19/97      100           100            100
              12/31/97      175          98.52          96.71

Section 16(a) Beneficial Ownership Reporting and Compliance

          Based solely  on a  review of  the reports under Section 16(a) of the
Exchange Act  and representations  furnished to  the Company  during  the  last
fiscal year,  the Company  believes that  each of  the persons required to file
such reports is in compliance with all applicable filing requirements.

                                      -9-

<PAGE>
Certain Transactions

          In March  1997, the  Company entered  into a loan guarantee agreement
(the "Loan  Guarantee Agreement")  with a principal stockholder of the Company,
Tudor BVI  Futures, Ltd.  ("Tudor BVI"),  and with  Tudor  Group  Holdings  LLC
("Tudor Group" and, together with Tudor BVI, the "Guarantors"), an affiliate of
Tudor Investment  Corporation, a  principal stockholder of the Company, wherein
the Guarantors agreed to guarantee the performance of the Company's obligations
under a  bank loan  agreement that provided for borrowings of up to $2,000,000.
Tudor BVI  agreed to  provide 78%  of the  guarantee, and Tudor Group agreed to
provide the  remaining 22%  of the  guarantee.    In  consideration  for  these
guarantees, the  Company issued  to Tudor  BVI and  Tudor  Global  Trading  LLC
("TGT"), a  subsidiary of  Tudor Group,  warrants to  purchase in the aggregate
54,600 shares  and 15,400  shares of Common Stock, respectively, at an exercise
price of  $4.00 per  share.   These warrants  are immediately  exercisable  and
expire in  March 2002.   In  July 1997,  the Company  repaid  $2.0  million  in
borrowings  outstanding   under  the  bank  loan  agreement,  representing  all
borrowings thereunder.

          Various directors,  officers and  5% stockholders  of the Company and
their respective  affiliates are  entitled to  certain registration rights with
respect to their securities of the Company.

          The Company  believes that  the  transactions  described  above  were
entered into  on terms  no less favorable to the Company than could be obtained
from third parties on an arm's length basis.


    PROPOSAL II: AMENDMENT OF THE COMPANY'S AMENDED 1996 STOCK INCENTIVE PLAN

          The Company's  Board of  Directors  has  determined  that  additional
shares of the Common Stock should be made available for awards to the Company's
employees, directors,  advisors and consultants who will be responsible for the
financial success  and growth of the business of the Company.  Accordingly, the
Board has  unanimously approved,  subject to stockholder approval, an amendment
to the Company's Amended 1996 Stock Incentive Plan (the "Plan") to increase the
maximum number  of shares  of Common  Stock available for grant thereunder from
1,050,000 shares  to 2,000,000  shares.   If the  amendment to  the Plan is not
approved by  the stockholders,  the Company will reevaluate how it will provide
incentives to  the Company's existing and future employees, directors, advisors
and consultants.

Summary of the Plan

          The following  is a  brief summary  of the  Plan as  proposed  to  be
amended.

          Purpose   The purpose  of the Plan is to promote the interests of the
Company and its stockholders by strengthening the Company's ability to attract,
motivate and  retain employees,  directors, advisors  and  consultants  and  to
provide a  means to encourage stock ownership and a proprietary interest in the
Company by  the employees,  directors,  advisors  and  consultants  upon  whose
judgment, initiative  and efforts  the financial  success  and  growth  of  the
business of the Company largely depend.

          Eligible Employees   The  eligible participants  in the  Plan are the
Company's employees,  directors, advisors  and consultants,  as determined  and
designated from  time to  time by  the Company's  Compensation Committee in its
sole discretion.   At  April 30,  1998 there  were 32 employees, 6 non-employee
directors and  approximately 25  other advisors  and  consultants  eligible  to
participate in the Plan.

                                      -10-

<PAGE>
          Grants Under  the Plan  The Plan provides for the grant of options to
purchase the  Common Stock  (including both  options  intended  to  qualify  as
incentive stock options under Section 422 of the Internal Revenue Code of 1986,
as amended  (the "Code"), and nonqualified options), stock appreciation rights,
restricted stock, performance shares and phantom stock, as described more fully
below.

          Administration     The  Plan  is  administered  by  the  Compensation
Committee of the Board of Directors of the Company.

          Subject to the provisions of the Plan, the Compensation Committee has
the authority  and discretion  to grant awards under the Plan, to interpret the
provisions of  the Plan  and the  award agreements  made thereunder and to take
such other  action as  may be  necessary or desirable in order to carry out the
provisions of the Plan.

          Maximum Shares  to be  Issued   The number  of shares of Common Stock
which may  be issued  pursuant to  the grant  of awards  under the Plan may not
exceed 2,000,000  in the  aggregate (subject to antidilution adjustments).  Any
shares subject  to an  award granted  under the  Plan that cease to be issuable
thereunder will thereafter be available for further award grants.

          Stock Option  Grants   The Compensation Committee specifies the terms
and conditions  of stock  options granted  under  the  Plan  including  without
limitation the number of shares covered by each option, the exercise price, the
option period,  any vesting  restrictions with  respect to  the exercise of the
option and  whether each  option is  intended to  qualify as an incentive stock
option.   No option  under the  Plan may have an option exercise period of more
than ten  years.   Options intending to qualify as incentive stock options must
have an  exercise price per share of not less than the fair market value of the
Common Stock  on the  date of grant.  Furthermore, options intending to qualify
as incentive stock options and granted to a person who at the time of the grant
holds more  than 10% of the total combined voting power of all classes of stock
of the  Company must  have an exercise price per share of not less than 110% of
the fair  market value  of the  Common Stock on the date of grant and an option
exercise period of not more than five years.

          Stock Appreciation  Rights   Stock appreciation  rights, which may be
granted alone  or in  tandem with  stock options,  entitle the  participant  to
receive in  cash or  in shares  of the  Common Stock the difference between the
fair market  value of the Common Stock on the date of exercise and a base price
set at  the time  of grant.  The Compensation Committee specifies the terms and
conditions of  the stock  appreciation rights  granted under the Plan including
without limitation  the number of shares covered by each grant, the base price,
the exercise  period (which  may in  no event  exceed ten  years), any  vesting
restrictions with  respect to  exercise and  whether payment will be in cash or
shares.

          Restricted Stock  Awards   Restricted stock is issued to participants
pursuant to  restrictions on  transfer and  subject to  risk of  forfeiture  if
certain conditions are not met, such as continuing employment with the Company.
The  Compensation   Committee  specifies  the  terms  and  conditions  of  each
restricted stock  award under  the Plan including without limitation the number
of shares  issued, the  price if  any to be paid for the shares and the vesting
schedule with respect to the lapse of restrictions.

                                      -11-

<PAGE>
          Performance Awards   Performance  awards entitle  the participant  to
receive cash  or shares  of the  Common Stock  upon the  achievement of certain
performance  goals.    The  Compensation  Committee  specifies  the  terms  and
conditions  of   the  performance  awards  under  the  Plan  including  without
limitation the dollar amount and number of shares covered by each award and the
performance goals  to be achieved and the period of time to achieve those goals
(which may  in no event exceed ten years).  The Compensation Committee may also
in its  discretion make  revisions to  the awards  subsequent to  their initial
grant and  will determine  the extent  to which  performance  goals  have  been
reached.

          Phantom Stock   Phantom  stock  awards  entitle  the  participant  to
receive a  cash payment  equal to a hypothetical number of shares of the Common
Stock times the difference between the fair market value of the Common Stock on
the date the award becomes vested and the fair market value of the Common Stock
on the  date of  grant.   The Compensation  Committee specifies  the terms  and
conditions of  the phantom  stock  awards  under  the  Plan  including  without
limitation the number of hypothetical shares covered by each grant, the vesting
period (which  may in  no event exceed ten years) and the maximum amount if any
to be paid under the award.

          Restrictions  on   Transfer    Awards  under  the  Plan  may  not  be
transferred by  a participant  other than by will or by the laws of descent and
distribution and may be exercised during the participant's lifetime only by the
participant.   Notwithstanding the  foregoing, participants  may, to the extent
permitted by  the Compensation  Committee,  transfer  nonqualified  options  to
members of the participant's immediate family or to charitable institutions.

          Federal Income  Tax Consequences   The grant of awards under the Plan
will have  no federal  income tax  consequences to  either the  Company or  the
participant (unless,  with respect  to the  issuance of  restricted stock,  the
participant files  an election to be taxed currently under section 83(b) of the
Code).   The exercise of incentive stock options will generally have no federal
income tax  consequences to either the Company or the participant, although the
excess of the value of the stock over the exercise price is potentially subject
to the  alternative minimum tax under Section 55 of the Code.  Upon exercise of
nonqualified options  or stock  appreciation rights,  the vesting of restricted
stock (or  the issuance  thereof if  the  participant  files  a  section  83(b)
election) and any payment to the participant with respect to performance awards
and phantom stock, the participant will be subject to federal income tax on the
excess of  the value of the stock over the amount paid therefor and the Company
will be  entitled to take a corresponding federal income tax deduction (subject
to the limitation on deductibility of executive compensation).

          The foregoing  is a  general description  of the  federal income  tax
consequences relating to the grant and payment with respect to awards under the
Plan.   It does  not purport  to  cover  the  special  rules  under  the  Code,
administrative and  judicial interpretations,  possible changes  in the  law or
state and local income tax consequences.

          Amendment   The Board  of Directors  of the  Company may  at any time
amend or  terminate the  Plan, provided  that no  such amendment  may  be  made
without the  approval of the stockholders of the Company to the extent approval
is required  by applicable laws, rules or regulations and provided further that
no amendment  or termination  may adversely  affect the rights of a participant
with respect to an outstanding award.

                                      -12-

<PAGE>
Grant Information

          At December  31, 1997, there were outstanding options with respect to
516,000 shares  of the  Common Stock  granted pursuant  to the Plan.  It is not
possible to  determine the  award grants that will be made pursuant to the Plan
in the  future.  The table below sets forth information regarding award grants,
all of  which were  in the  form of  stock option  grants, made  under the Plan
during the fiscal year ended December 31, 1997.

                                                       Number of
                                          Dollar     Shares Under-
   Name and Position                      Value*     lying Options

Paul J. Maddon, M.D., Ph.D..........        -             -    
 Chairman of the Board, President,
 Chief Executive Officer and Chief
 Science Officer

Robert J. Israel, M.D...............        -            75,000
 Vice President, Medical Affairs

Robert A. McKinney..................        -            40,000
 Vice President, Finance and
 Operations and Treasurer

All current executive officers
 as a group.........................        -           115,000

All current directors who are not
 executive officers as a group .....        -            75,000

All employees, including all current
 officers who are not executive
 officers, as a group...............        -           116,500
_______________

* Based upon  the excess  of the  fair market  value of the Common Stock on the
 date of grant over the exercise price.

Voting

          Under applicable rules of the Nasdaq Stock Market, the amendment must
be approved  by the affirmative vote of the holders of a majority of the shares
of the  Common Stock  present, or  represented, and  entitled to  vote  at  the
meeting.   Abstentions from  voting on  this proposal will have the effect of a
"no" vote.   Broker  non-votes are  not  considered  shares  present,  are  not
entitled to  vote and therefore will not affect the outcome of the vote on this
proposal.


          The Board  of Directors  of the  Company deems  the amendment  to the
Company's Amended  1996 Stock  Incentive Plan to be in the best interest of the
Company and  its stockholders  and recommends  that holders of the Common Stock
vote FOR Proposal II.

                                      -13-

<PAGE>
 PROPOSAL III: ADOPTION OF THE COMPANY'S 1998 EMPLOYEE STOCK PURCHASE PLAN AND
                1998 NON-QUALIFIED EMPLOYEE STOCK PURCHASE PLAN

          The Company's  Board of Directors has determined that it is desirable
to encourage  employees of  the Company  to acquire  an equity  interest in the
Company's success  by making  shares of the Common Stock available for purchase
by all  employees on  favorable terms.   Accordingly, the Board has unanimously
approved, subject  to stockholder  approval, (i)  the adoption of the Company's
1998 Employee  Stock Purchase  Plan (the  "ESPP") providing  for the  grant  to
employees of  the Company  of options  to purchase  up to 150,000 shares of the
Common Stock and (ii) the adoption of the Company's 1998 Non-Qualified Employee
Stock Purchase  Plan (the  "Non-Qualified ESPP")  providing for  the  grant  to
employees of  the Company  of options  to purchase  up to  50,000 shares of the
Common Stock.   The texts of the ESPP and the Non-Qualified ESPP (collectively,
the "Plans")  are set  forth at  Appendix  A  hereto  and  Appendix  B  hereto,
respectively.

          The Company's  Board of  Directors has  authorized the  grant of  the
first options  under the Plans, subject to stockholder approval, effective July
1, 1998.  If the Plans are not approved by the stockholders of the Company, the
Company will  rescind the options granted thereunder and will reconsider how it
will encourage  employees of  the Company  to acquire an equity interest in the
Company's success.

Summary of the Plans

          The following is a brief summary of the Plans.

          Purpose   The  purpose  of  the  Plans  is  to  aid  the  Company  in
attracting, compensating  and retaining  well qualified  employees by providing
them with an equity interest in the Company's success.

          Eligible Employees     Substantially all  employees of  the  Company,
including executive  officers, are  eligible to  participate in the Plans.  Any
employee holding  a beneficial  interest in more than 5% of the Common Stock is
not eligible to participate in the ESPP and will participate solely in the Non-
Qualified ESPP.   At  April 30,  1998 there  were 32  employees of  the Company
eligible to participate in the Plans.

          Options Under  the Plans   The  Plans provide  for  the  grant  on  a
quarterly basis  starting July  1, 1998 of options to purchase the Common Stock
with up  to 25%  of each employee's pay during such quarter, as such percentage
may be  determined by  the Board  of Directors  of the  Company.   The Board of
Directors has determined that the initial option grants under the Plans will be
for only 10% of each employee's pay during the fiscal quarter from July 1, 1998
to September 30, 1998.

          Each option  will expire  six months after the date of grant and must
be exercised  on a  date chosen  by each employee during the three-month period
prior to  the date of expiration.  Payment for the shares upon exercise will be
in cash  or, at  the discretion  of the  Compensation Committee of the Board of
Directors, in  shares of  the Common  Stock.  The Company will not withhold any
amount from any employee's pay prior to exercise of an option.

          The ESPP  provides that  the fair  market value  of the option shares
subject to  a grant  on the first day of the quarter may not exceed $6,250.  In
the event  any employee's  pay is  such that  the applicable percentage thereof
determined by  the Board  of Directors  of the Company results in option shares
having greater  than a  $6,250 fair  market value,  such excess will be granted
from the Non-Qualified ESPP.

                                      -14-

<PAGE>
          Administration   The  Plans  are  administered  by  the  Compensation
Committee of the Board of Directors of the Company.

          To  the  extent  not  otherwise  inconsistent  with  the  Plans,  the
Compensation Committee  has the  authority and discretion to amend the terms of
future grants under the Plans and to terminate further grants under the Plans.

          Maximum Shares  to be  Awarded   The number  of shares  of the Common
Stock with  respect to  which options  may be  granted under  the ESPP  may not
exceed 150,000  in the  aggregate (subject  to antidilution  adjustments).  The
number of  shares of  the Common  Stock with  respect to  which options  may be
granted under  the Non-Qualified  ESPP may  not exceed  50,000 in the aggregate
(subject to  antidilution adjustments).   Any shares subject to options granted
under the  Plans that are returned to the Plans may thereafter be available for
further grants.

          Exercise Price  of Options  The price at which employees may exercise
options will  be the  lesser of (i) 100% of the fair market value of the Common
Stock on  the first  day of  each fiscal quarter or (ii) 85% of the fair market
value of  the Common  Stock on  the date  of exercise.   At April 20, 1998, the
closing price  of the Common Stock on the Nasdaq National Market was $19.31 per
share.

          Restrictions on  Transfer    Options  under  the  Plans  may  not  be
transferred by  an employee  other than  by will  or by the laws of descent and
distribution and  may be  exercised during  the employee's lifetime only by the
employee.

          Federal Income  Tax Consequences  The ESPP is intended to comply with
the requirements  of Section  423 of  the Internal  Revenue Code  of  1986,  as
amended.  As such, neither the grant of options under the ESPP nor the exercise
of the  options by  employees will  have any federal income tax consequences to
either the Company or the employee.  Under the Non-Qualified ESPP, the grant of
options will  have no  federal income tax consequences to either the Company or
the employee.   The  exercise of  the options  granted under  the Non-Qualified
ESPP, however, will result in taxable income to the employee in an amount equal
to the  difference between  the purchase price and the fair market value on the
date of  exercise and  will result  in a  corresponding deduction  from taxable
income for the Company (subject to the limitation on deductibility of executive
compensation).

          Since there  is no  provision under  the Plans for the payment of the
exercise price  through payroll  withholding,  the  Company  expects  that  the
majority  of  employees  who  exercise  options  will  immediately  resell  the
underlying shares.   In such event, the resale will result in taxable income to
the employee in an amount equal to the difference between the net proceeds from
the resale  and the  purchase price upon exercise of the option and will result
in a  corresponding deduction  from taxable  income for the Company (subject to
the limitation on deductibility of executive compensation).

          Amendment   The Board  of Directors  of the  Company may  at any time
amend the  Plans, provided  that no  such amendment  shall be  made without the
approval of  the stockholders of the Company to the extent approval is required
by applicable laws, rules or regulations.

                                      -15-

<PAGE>
Grant Information

          Under the  Plans, employees  are entitled to apply up to 25% of their
gross pay to the purchase of the Common Stock, with a limit of $25,000 per year
under the ESPP and any remainder under the Non-Qualified ESPP.  The table below
sets forth  certain information  as to  annual grants to be made under the ESPP
and the  Non-Qualified ESPP  if approved,  assuming that compensation is at the
same level  as at  the end of the 1997 fiscal year, that the Board of Directors
authorizes the  maximum percentage  of pay allowed under the Plans and that all
employees participate in the Plans to the full extent allowed.

                                   Share Value of Annual Grants
                                                  Non-Qual-          Number
Name and Position                       ESPP      ified ESPP     of Shares (1)

Paul J. Maddon, M.D., Ph.D......         (2)        $112,500         5,825
 Chairman of the Board,
 President, Chief Executive
 Officer and Chief Science
 Officer

Robert J. Israel, M.D...........      $25,000         32,500         2,977
 Vice President, Medical
 Affairs

Robert A. McKinney..............       25,000          6,500         1,631
 Vice President, Finance and
 Operations and Treasurer

All current executive officers
 as a group.....................       50,000        151,500        10,434

All current directors who are not
 executive officers as a group (3)       -              -             -   

All employees, including all
 current officers who are not
 executive officers, as a group.     $304,801           -           15,783

_______________
(1)Based on  the assumption  that the closing price of $19.31 on April 20, 1998
   on the Nasdaq National Market will be the exercise price with respect to the
   options granted under the Plans.

(2)As the  holder of a beneficial interest in more than 5% of the Common Stock,
   Dr. Maddon is not eligible for an option grant under the ESPP.

(3)Directors of  the Company  who are not also employees of the Company are not
   eligible to participate in the Plans.

Voting

          Under applicable  rules of the Nasdaq Stock Market, the Plans must be
approved by  the affirmative vote of the holders of a majority of the shares of
the Common  Stock present, or represented, and entitled to vote at the meeting.
Abstentions from  voting on  this proposal will have the effect of a "no" vote.
Broker non-votes  are not  considered shares  present, are not entitled to vote
and therefore will not affect the outcome of the vote on this proposal.

          The Board  of Directors  of the  Company deems  the adoption  of  the
Company's 1998  Employee Stock  Purchase Plan  and 1998  Non-Qualified Employee
Stock Purchase  Plan to  be in  the  best  interest  of  the  Company  and  its
stockholders and  recommends that holders of the Common Stock vote FOR Proposal
III.

                                      -16-

<PAGE>
      PROPOSAL IV:  RATIFICATION OF SELECTION OF INDEPENDENT ACCOUNTANTS

          The Board of Directors has selected Coopers & Lybrand L.L.P. to serve
as independent  accountants for  the fiscal  year  ending  December  31,  1998.
Coopers &  Lybrand L.L.P.  has served  as the Company's independent accountants
since 1994.

          A representative  of Coopers  & Lybrand  L.L.P.  is  expected  to  be
present at  the meeting  with the opportunity to make a statement if he desires
to do  so and  is expected to be available to respond to appropriate questions.
Although it  is not required to do so, the Board of Directors is submitting the
selection of  independent accountants for ratification at the meeting.  If this
selection is not ratified, the Board of Directors will reconsider its choice.

          A majority  of the  votes cast (excluding abstentions and broker non-
votes) at  the meeting  in person  or by proxy is necessary for ratification of
the selection  of Coopers  & Lybrand  L.L.P. as  independent accountants of the
Company.

          The Board  of Directors  of the Company deems the ratification of the
selection of Coopers & Lybrand L.L.P. as independent accountants of the Company
to be  in the  best interest of the Company and its stockholders and recommends
that holders of the Common Stock vote FOR Proposal IV.


                                   FORM 10-K

          Stockholders may obtain without charge a copy of the Company's Annual
Report on  Form 10-K  for the fiscal year ended December, 31, 1997 by directing
written requests  to Investor  Relations, Progenics  Pharmaceuticals, Inc., 777
Old Saw Mill River Road, Tarrytown, New York  10591.


                             STOCKHOLDER PROPOSALS

          All stockholder  proposals which  are intended to be presented at the
Annual Meeting  of Stockholders  of the Company contemplated to be held in June
1999 must  be received  by the  Company no  later than  December 31,  1998, for
inclusion in the Board of Directors' proxy statement and form of proxy relating
to the meeting.


                                OTHER BUSINESS

          The Board of Directors knows of no other business to be acted upon at
the meeting.  However, if any other business properly comes before the meeting,
it is  the intention of the persons named in the enclosed proxy to vote on such
matters in accordance with their best judgment.

          The prompt  return of  your proxy  will be appreciated and helpful in
obtaining the  necessary vote.   Therefore, whether or not you expect to attend
the meeting, please sign the proxy and return it in the enclosed envelope.


                                   By order of the Board of Directors

                                   ROBERT A. MCKINNEY
                                   Secretary

Tarrytown, New York
May 1, 1998

                                      -17-

<PAGE>
                                                                     APPENDIX A

                        PROGENICS PHARMACEUTICALS, INC.


                         EMPLOYEE STOCK PURCHASE PLAN

                                150,000 Shares


1.   Purpose

     The purpose  of the Employee Stock Purchase Plan (the "Plan") of Progenics
Pharmaceuticals, Inc. (the "Company") is to attract, compensate and retain well
qualified employees  by providing them with an equity interest in the Company's
success.

2.   Stock Subject to the Plan

     The Company  may issue  and sell  a total  of 150,000 shares of its common
stock, par  value $.0013  per share (the "Common Stock"), pursuant to the Plan.
Such shares may be either authorized but unissued shares or treasury shares and
may include  shares that have been subject to unexercised options, whether such
options  have  terminated  or  expired  by  their  terms,  by  cancellation  or
otherwise.

3.   Administration

     The Plan shall be administered by a committee (the "Committee") consisting
of the  entire Board of Directors of the Company or of two or more non-employee
directors thereof.   The Committee shall have the power and authority as may be
necessary to carry out the provisions of the Plan, including the interpretation
and construction  of the  Plan and  the option  grants made under the Plan, the
adoption of  such rules  and regulations  as it  may  deem  advisable  and  the
termination of further option grants under the Plan.

4.   Eligibility

     Options under  the Plan shall be granted only to employees of the Company,
all employees  of the  Company are  eligible to  receive option  grants and all
employees granted  options under  the Plan  shall  have  the  same  rights  and
privileges.  Notwithstanding the foregoing, (i) no employee shall be granted an
option if  such employee,  immediately after  the option is granted, owns stock
possessing 5%  or more  of the  total combined  voting power  or value  of  all
classes of stock of the Company, within the meaning of Section 423(b)(3) of the
Internal Revenue  Code of  1986, as  amended (the  "Code") and (ii) no employee
shall be granted an option which permits his rights to purchase stock under the
Plan to  accrue at a rate which exceeds $6,250 of the fair market value of such
stock (determined  at the  time such option is granted) for each fiscal quarter
in which  such option  is outstanding  at any time.  Furthermore, the Committee
may in  its sole  discretion impose  such restrictions on eligibility as may be
permitted by Section 423(b)(4) of the Code.

5.   Option Grants

     Until such time as the Committee in its sole discretion terminates further
option grants  under the  Plan, all eligible employees of the Company shall, on
July 1,  October 1,  January 1  and April  1 of each year (the "Date of Grant")
starting July  1, 1998, be granted an option to purchase the Common Stock, each
such option to be subject and pursuant to the following terms and conditions:

          (a)  Option Term   The  term of each option shall be from the Date of
     Grant to  the date  six months  after the  Date of  Grant  (the  "Date  of
     Expiration").

                                     A-1

<PAGE>
          (b)  Option Price   The purchase price per share for each option (the
     "Option Price")  shall be  the lesser  of (i) the fair market value of the
     Common Stock  on the Date of Grant or (ii) 85% of the fair market value of
     the Common  Stock on the Date of Exercise (as such term is defined below).
     As used  herein, the  fair market value of the Common Stock on the Date of
     Grant shall  be the  closing price  of the  Common  Stock  on  the  Nasdaq
     National Market on the date prior to the Date of Grant and the fair market
     value of  the Common  Stock on  the Date  of Exercise shall be the closing
     price of  the Common  Stock on  the Nasdaq  National Market on the Date of
     Exercise provided,  however, that,  if the  employee exercising the option
     resells the  shares on the Date of Exercise, the average selling price for
     such shares,  before the  payment of  brokerage commissions  and expenses,
     shall be  the fair market value on the Date of Exercise.  In the event the
     Common Stock  ceases at  any time  to be  traded on  the  Nasdaq  National
     Market, the  fair market  value of the Common Stock shall be determined in
     such manner as may be set by the Committee.

          (c)  Number of  Option Shares   Unless and until the Committee in its
     sole discretion determines otherwise, the number of shares subject to each
     option shall be the whole number equal to (i) up to 25% of each employee's
     total compensation  during the  fiscal quarter  starting with  the Date of
     Grant, as  such percentage  shall be  determined by the Committee prior to
     the Date  of Grant, divided by (ii) the lesser of the fair market value of
     the Common  Stock on  the Date of Grant or 85% of the closing price of the
     Common Stock  on the  Nasdaq National Market on the date prior to the Date
     of Exercise (or such other manner for determining the fair market value of
     the Common  Stock on  such date  if not then traded on the Nasdaq National
     Market).   In no event, however, shall the number of shares subject to any
     option exceed  $6,250 divided by the fair market value of the Common Stock
     on the Date of Grant.

          (d)  Exercise   The date  of exercise  of each  option (the  "Date of
     Exercise") shall be a date during the three-month period starting with the
     date three  months after  the Date  of Grant  and ending  on the  Date  of
     Expiration, as  chosen by  each employee.  Exercise shall not be made with
     respect to less than the total number of shares subject to each option and
     shall be  effected by delivering to the Company written notice of exercise
     at least  one day  prior to  the Date  of Exercise.   Notwithstanding  the
     foregoing, each  employee who  is subject  to Section 16 of the Securities
     Exchange Act  of 1934,  as amended  (the "Exchange Act"), shall deliver to
     the Company  written notice  of exercise  at least six months prior to the
     Date of  Exercise and, absent such notice, shall be deemed to have made an
     irrevocable election  to  have  the  Date  of  Exercise  be  the  Date  of
     Expiration.

          (e)  Payment   Payment for the shares purchased upon exercise of each
     option (including  the amount, if any, necessary to satisfy federal, state
     or local income tax withholding requirements) shall be in cash within five
     business days  following the Date of Exercise and, in the event payment is
     not received,  the Company  may withhold the shares and cancel the option.
     Notwithstanding the  foregoing, the  Committee may  in its sole discretion
     permit employees  (i) to  pay for shares acquired upon exercise of options
     by delivering shares of the Common Stock owned by such employee or (ii) to
     forgo payment  for the shares and receive instead the net number of shares
     that would  be received  if such  employee borrowed  shares of  the Common
     Stock for  payment of  the purchase price and returned the borrowed shares
     from the shares acquired upon exercise of the option.

                                     A-2

<PAGE>
          (f)  Termination of Employment  In the event an employee's employment
     with the  Company terminates  for any  reason other  than  the  employee's
     death, any  option held by such employee shall forthwith terminate without
     any further  rights on  the part  of the  employee.   In the  event of  an
     employee's  death,   the  employee's   estate,  legal   representative  or
     beneficiary may  exercise any  option held  by such  employee at  any time
     prior to  the Date  of Expiration  with respect  to such  option.  Nothing
     herein shall  be deemed  to confer  any right of continued employment with
     the Company  or to  limit the right of the Company to terminate employment
     with any employee.

6.   Rights as a Stockholder

     Until such  time as each option has been exercised and the shares acquired
thereby have  been issued  and delivered  to  the  employee  pursuant  to  such
exercise, the  employee shall  have no  rights as a stockholder with respect to
the shares of the Common Stock  subject to the option.

7.   Nontransferability of the Option

     Any option  granted under  the Plan  may not  be assigned  or  transferred
except by  will or  by the  laws of descent and distribution and is exercisable
during the life of the employee only by the employee.

8.   Compliance with Securities Laws

     If the  shares to  be issued upon exercise of any option granted under the
Plan have not been registered under the Securities Act of 1933, as amended, and
any applicable  state securities  laws, the  Company's obligation to issue such
shares shall  be conditioned  upon receipt  of a representation in writing that
the employee is acquiring such shares for his or her own account and not with a
view to  the distribution  thereof and the certificate representing such shares
shall bear  a legend  in such  form as the Company's counsel deems necessary or
desirable.   In no  event shall  the Company  be obligated  to issue any shares
pursuant to  the exercise  of an  option if,  in the  opinion of  the Company's
counsel, such  issuance would  result in  a violation  of any  federal or state
securities laws.

9.   Change of Control

     In the  event of  a Change of Control (as such term is defined below), all
outstanding options  under the  Plan shall immediately become fully exercisable
and all  of the rights and benefits relating thereto shall become fixed and not
subject to  change or  revocation by  the Company.  As used herein, a Change of
Control shall  be deemed  to have occurred if (i) any person within the meaning
of Section  13(d) and  14(d) of the Exchange Act, other than the Company or any
officer or  director of  the Company,  becomes the beneficial owner, within the
meaning of  Rule 13d-3  under the  Exchange Act, of 20% or more of the combined
voting securities  of the  Company or  (ii) a  change of  20% or  more  in  the
composition of  the Board  of Directors  of  the  Company  occurs  without  the
approval of  the majority  of said  Board of Directors as it exists at the time
immediately preceding such change in composition.

10.  Stock Adjustments

     (a)  In the  event of  a stock  dividend, stock  split,  recapitalization,
merger in  which the  Company is  the surviving  corporation or  other  capital
adjustment affecting the outstanding shares of the Common Stock, an appropriate
adjustment shall  be made,  as determined  by the  Board of  Directors  of  the
Company, to the number of shares subject to the Plan and the exercise price per
share with respect to any option granted under the Plan.

     (b)  In the  event of  the complete  liquidation of  the Company  or of  a
reorganization, consolidation  or merger  in  which  the  Company  is  not  the
surviving corporation, any option granted under the Plan shall continue in full
force and  effect unless  either (i)  the Board  of Directors  of  the  Company
modifies such option so that it is fully exercisable with respect to the number
of shares measured by the then current compensation prior to the effective date
of such transaction or (ii) the surviving corporation issues or assumes a stock
option contemplated by Section 424(a) of the Code.

                                     A-3

<PAGE>
11.  Effectiveness of the Plan

     The Plan  has been adopted on April 22, 1998 by resolution of the Board of
Directors of  the Company  and shall  become effective upon the approval by the
affirmative votes  of the holders of a majority of the Common Stock present, or
represented, and entitled to vote at a meeting duly held in accordance with the
applicable laws of the State of Delaware.

12.  Amendment of the Plan

     The Board  may at  any time alter, amend, suspend or terminate the Plan in
whole or  in part,  provided,  however,  that  (i)  no  alteration,  amendment,
suspension or termination shall adversely affect the rights of an employee with
respect to  any outstanding  options  granted  under  the  Plan  and  (ii)  any
amendment which must be approved by the stockholders of the Company in order to
ensure that  all transactions  under the  Plan  continue  to  be  exempt  under
Rule 16b-3 under  the Exchange Act or any successor provision or to comply with
any rule  or regulation  of a  governmental  authority,  applicable  securities
exchange or Nasdaq National Market shall not be effective unless and until such
stockholder approval  has  been  obtained  in  compliance  with  such  rule  or
regulation.

                                     A-4

<PAGE>
                                                                     APPENDIX B

                        PROGENICS PHARMACEUTICALS, INC.


                  NON-QUALIFIED EMPLOYEE STOCK PURCHASE PLAN

                                 50,000 Shares


1.   Purpose

     The purpose of the Non-Qualified Employee Stock Purchase Plan (the "Plan")
of Progenics  Pharmaceuticals, Inc.  (the "Company") is to provide employees of
the Company  with the  same equity interest in the Company's success they would
have under the Company's qualified Employee Stock Purchase Plan (the "Qualified
Plan") but  for the  limitations imposed by Section 423 of the Internal Revenue
Code (the  "Code"), which  limitations are  set  forth  in  Section  4  of  the
Qualified Plan.

2.   Stock Subject to the Plan

     The Company  may issue  and sell  a total  of 50,000  shares of its common
stock, par  value $.0013  per share (the "Common Stock"), pursuant to the Plan.
Such shares may be either authorized but unissued shares or treasury shares and
may include  shares that have been subject to unexercised options, whether such
options  have  terminated  or  expired  by  their  terms,  by  cancellation  or
otherwise.

3.   Administration

     The Plan shall be administered by a committee (the "Committee") consisting
of the  entire Board of Directors of the Company or of two or more non-employee
directors thereof.   The Committee shall have the power and authority as may be
necessary to carry out the provisions of the Plan, including the interpretation
and construction  of the  Plan and  the option  grants made under the Plan, the
adoption of  such rules  and regulations  as it  may  deem  advisable  and  the
termination of further option grants under the Plan.

4.   Eligibility

     Options under  the Plan shall be granted only to employees of the Company,
all employees  of the  Company are  eligible to  receive option  grants and all
employees granted  options under  the Plan  shall  have  the  same  rights  and
privileges.   Notwithstanding the  foregoing, no  employee shall  be granted an
option if  such employee  (i) is  eligible to  be  granted  options  under  the
Qualified Plan  and (ii)  is granted  options under  the Qualified  Plan  which
permit his  rights to  purchase stock  thereunder to  accrue at a rate which is
less than $6,250 of the fair market value of such stock (determined at the time
such option  is granted)  for each  fiscal quarter  in  which  such  option  is
outstanding at any time.  Furthermore, the Committee may in its sole discretion
impose such  restrictions  on  eligibility  as  may  be  permitted  by  Section
423(b)(4) of the Code.

5.   Option Grants

     Until such time as the Committee in its sole discretion terminates further
option grants  under the  Plan, all eligible employees of the Company shall, on
July 1,  October 1,  January 1  and April 1  of each year (the "Date of Grant")
starting July  1, 1998, be granted an option to purchase the Common Stock, each
such option to be subject and pursuant to the following terms and conditions:

          (a)  Option Term   The  term of each option shall be from the Date of
     Grant to  the date  six months  after the  Date of  Grant  (the  "Date  of
     Expiration").

                                         B-1

<PAGE>
          (b)  Option Price   The purchase price per share for each option (the
     "Option Price")  shall be  the lesser  of (i) the fair market value of the
     Common Stock  on the Date of Grant or (ii) 85% of the fair market value of
     the Common  Stock on the Date of Exercise (as such term is defined below).
     As used  herein, the  fair market value of the Common Stock on the Date of
     Grant shall  be the  closing price  of the  Common  Stock  on  the  Nasdaq
     National Market on the date prior to the Date of Grant and the fair market
     value of  the Common  Stock on  the Date  of Exercise shall be the closing
     price of  the Common  Stock on  the Nasdaq  National Market on the Date of
     Exercise provided,  however, that,  if the  employee exercising the option
     resells the  shares on the Date of Exercise, the average selling price for
     such shares,  before the  payment of  brokerage commissions  and expenses,
     shall be  the fair market value on the Date of Exercise.  In the event the
     Common Stock  ceases at  any time  to be  traded on  the  Nasdaq  National
     Market, the  fair market  value of the Common Stock shall be determined in
     such manner as may be set by the Committee.

          (c)  Number of  Option Shares   Unless and until the Committee in its
     sole discretion determines otherwise, the number of shares subject to each
     option shall be the whole number equal to (i) up to 25% of each employee's
     total compensation  during the  fiscal quarter  starting with  the Date of
     Grant, as  such percentage  shall be  determined by the Committee prior to
     the Date  of Grant, divided by (ii) the lesser of the fair market value of
     the Common  Stock on  the Date of Grant or 85% of the closing price of the
     Common Stock  on the  Nasdaq National Market on the date prior to the Date
     of Exercise (or such other manner for determining the fair market value of
     the Common  Stock on  such date  if not then traded on the Nasdaq National
     Market) minus  (iii) the  number of  shares subject  to an  option granted
     under the Qualified Plan with the same Date of Grant.

          (d)  Exercise   The date  of exercise  of each  option (the  "Date of
     Exercise") shall be a date during the three-month period starting with the
     date three  months after  the Date  of Grant  and ending  on the  Date  of
     Expiration, as  chosen by  each employee.  Exercise shall not be made with
     respect to less than the total number of shares subject to each option and
     shall be  effected by delivering to the Company written notice of exercise
     at least  one day  prior to  the Date  of Exercise.   Notwithstanding  the
     foregoing, each  employee who  is subject  to Section 16 of the Securities
     Exchange Act  of 1934,  as amended  (the "Exchange Act"), shall deliver to
     the Company  written notice  of exercise  at least six months prior to the
     Date of  Exercise and, absent such notice, shall be deemed to have made an
     irrevocable election  to  have  the  Date  of  Exercise  be  the  Date  of
     Expiration.

          (e)  Payment   Payment for the shares purchased upon exercise of each
     option (including  the amount, if any, necessary to satisfy federal, state
     or local income tax withholding requirements) shall be in cash within five
     business days  following the Date of Exercise and, in the event payment is
     not received,  the Company  may withhold the shares and cancel the option.
     Notwithstanding the  foregoing, the  Committee may  in its sole discretion
     permit employees  (i) to  pay for shares acquired upon exercise of options
     by delivering shares of the Common Stock owned by such employee or (ii) to
     forgo payment  for the shares and receive instead the net number of shares
     that would  be received  if such  employee borrowed  shares of  the Common
     Stock for  payment of  the purchase price and returned the borrowed shares
     from the shares acquired upon exercise of the option.

                                         B-2

<PAGE>
          (f)  Termination of Employment  In the event an employee's employment
     with the  Company terminates  for any  reason other  than  the  employee's
     death, any  option held by such employee shall forthwith terminate without
     any further  rights on  the part  of the  employee.   In the  event of  an
     employee's  death,   the  employee's   estate,  legal   representative  or
     beneficiary may  exercise any  option held  by such  employee at  any time
     prior to  the Date  of Expiration  with respect  to such  option.  Nothing
     herein shall  be deemed  to confer  any right of continued employment with
     the Company  or to  limit the right of the Company to terminate employment
     with any employee.

6.   Rights as a Stockholder

     Until such  time as each option has been exercised and the shares acquired
thereby have  been issued  and delivered  to  the  employee  pursuant  to  such
exercise, the  employee shall  have no  rights as a stockholder with respect to
the shares of the Common Stock subject to the option.

7.   Nontransferability of the Option

     Any option  granted under  the Plan  may not  be assigned  or  transferred
except by  will or  by the  laws of descent and distribution and is exercisable
during the life of the employee only by the employee.

8.   Compliance with Securities Laws

     If the  shares to  be issued upon exercise of any option granted under the
Plan have not been registered under the Securities Act of 1933, as amended, and
any applicable  state securities  laws, the  Company's obligation to issue such
shares shall  be conditioned  upon receipt  of a representation in writing that
the employee is acquiring such shares for his or her own account and not with a
view to  the distribution  thereof and the certificate representing such shares
shall bear  a legend  in such  form as the Company's counsel deems necessary or
desirable.   In no  event shall  the Company  be obligated  to issue any shares
pursuant to  the exercise  of an  option if,  in the  opinion of  the Company's
counsel, such  issuance would  result in  a violation  of any  federal or state
securities laws.

9.   Change of Control

     In the  event of  a Change of Control (as such term is defined below), all
outstanding options  under the  Plan shall immediately become fully exercisable
and all  of the rights and benefits relating thereto shall become fixed and not
subject to  change or  revocation by  the Company.  As used herein, a Change of
Control shall  be deemed  to have occurred if (i) any person within the meaning
of Section  13(d) and  14(d) of the Exchange Act, other than the Company or any
officer or  director of  the Company,  becomes the beneficial owner, within the
meaning of  Rule 13d-3  under the  Exchange Act, of 20% or more of the combined
voting securities  of the  Company or  (ii) a  change of  20% or  more  in  the
composition of  the Board  of Directors  of  the  Company  occurs  without  the
approval of  the majority  of said  Board of Directors as it exists at the time
immediately preceding such change in composition.

                                         B-3

<PAGE>
10.  Stock Adjustments

     (a)  In the  event of  a stock  dividend, stock  split,  recapitalization,
merger in  which the  Company is  the surviving  corporation or  other  capital
adjustment affecting the outstanding shares of the Common Stock, an appropriate
adjustment shall  be made,  as determined  by the  Board of  Directors  of  the
Company, to the number of shares subject to the Plan and the exercise price per
share with respect to any option granted under the Plan.

     (b)  In the  event of  the complete  liquidation of  the Company  or of  a
reorganization, consolidation  or merger  in  which  the  Company  is  not  the
surviving corporation, any option granted under the Plan shall continue in full
force and  effect unless  either (i)  the Board  of Directors  of  the  Company
modifies such option so that it is fully exercisable with respect to the number
of shares measured by the then current compensation prior to the effective date
of such transaction or (ii) the surviving corporation issues or assumes a stock
option contemplated by Section 424(a) of the Code.

11.  Effectiveness of the Plan

     The Plan  has been adopted on April 22, 1998 by resolution of the Board of
Directors of  the Company  and shall  become effective upon the approval by the
affirmative votes  of the holders of a majority of the Common Stock present, or
represented, and entitled to vote at a meeting duly held in accordance with the
applicable laws of the State of Delaware.

12.  Amendment of the Plan

     The Board  may at  any time alter, amend, suspend or terminate the Plan in
whole or  in part,  provided,  however,  that  (i)  no  alteration,  amendment,
suspension or termination shall adversely affect the rights of an employee with
respect to  any outstanding  options  granted  under  the  Plan  and  (ii)  any
amendment which must be approved by the stockholders of the Company in order to
ensure that  all transactions  under the  Plan  continue  to  be  exempt  under
Rule 16b-3 under  the Exchange Act or any successor provision or to comply with
any rule  or regulation  of a  governmental  authority,  applicable  securities
exchange or Nasdaq National Market shall not be effective unless and until such
stockholder approval  has  been  obtained  in  compliance  with  such  rule  or
regulation.

                                         B-4

<PAGE>
                        PROGENICS PHARMACEUTICALS, INC.
                          777 Old Saw Mill River Road
                           Tarrytown, New York 10591

          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

     The undersigned  hereby appoints Paul J. Maddon, M.D., Ph.D. and Robert A.
McKinney, and  each of  them, as  Proxies each  with the  power to  appoint his
substitute and  hereby authorizes  them to represent and to vote, as designated
below, all  of the  shares of  Common Stock  of Progenics Pharmaceuticals, Inc.
held of  record by  the undersigned  on May  1, 1998  at the  Annual Meeting of
Stockholders to  be held  on June  9, 1998 or any adjournments or postponements
thereof.

1.   ELECTION OF DIRECTORS

          Nominees:                 
 Paul J. Maddon, M.D., Ph.D.        STOCKHOLDERS  MAY  WITHHOLD  AUTHORITY  TO
       Charles A. Baker             VOTE FOR  ANY NOMINEE  BY DRAWING  A  LINE
        Mark F. Dalton              THROUGH OR OTHERWISE STRIKING OUT THE NAME
    Stephen P. Goff, Ph.D.          OF SUCH  NOMINEE.   ANY PROXY  EXECUTED IN
     Elizabeth M Greetham           SUCH MANNER  AS NOT  TO WITHHOLD AUTHORITY
       Paul F. Jacobson             TO VOTE  FOR THE  ELECTION OF  ANY NOMINEE
 David A. Scheinberg, M.D., Ph.D.   SHALL BE DEEMED TO GRANT SUCH AUTHORITY.

        _ GRANT authority  to vote for  _ WITHOLD  authority to
          the  seven   nominees  as  a    vote  for  the  seven
          group                           nominees as a group

2.   Approval and  adoption of an amendment to the Company's Amended 1996 Stock
     Incentive Plan  increasing the  maximum number  of shares of the Company's
     Common Stock available thereunder for issuance from 1,050,000 to 2,000,000
     shares

        _ FOR           _ AGAINST       _ ABSTAIN

3.   Approval and  adoption of  the Company's 1998 Employee Stock Purchase Plan
     providing for the issuance of up to 150,000 shares of the Company's Common
     Stock and  1998 Non-Qualified  Employee Stock  Purchase Plan providing for
     the issuance of up to 50,000 shares of the Company's Common Stock

        _ FOR           _ AGAINST       _ ABSTAIN

4.   Ratification of  the Board  of Directors'  selection of  Coopers & Lybrand
     L.L.P. to  serve as  the Company's  independent accountants for the fiscal
     year ending December 31, 1998

        _ FOR           _ AGAINST       _ ABSTAIN

5.   Authority to  vote in  their discretion  on such  other  business  as  may
     properly come before the meeting

        _ FOR           _ AGAINST       _ ABSTAIN

     This proxy,  when properly  executed, will be voted in the manner directed
herein by  the undersigned  stockholder.   If no  direction is made, this proxy
will be voted for each of the proposals named above.

PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY, USING THE ENCLOSED
                                   ENVELOPE.


                                   Dated                        , 1998

                                                                      
                                                   (Signature)

                                                                      
                                           (Signature if held jointly)

                                   Please sign  exactly as name appears hereon.
                                   When shares  are held by joint tenants, both
                                   should sign.    When  signing  as  attorney,
                                   executor,    administrator,    trustee    or
                                   guardian, please  give full  title as  such.
                                   If  a   corporation,  please  sign  in  full
                                   corporate  name   by  president   or   other
                                   authorized  officer.     If  a  partnership,
                                   please   sign   in   partnership   name   by
                                   authorized person.


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