PROGENICS PHARMACEUTICALS INC
SC 13G/A, 1999-02-11
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549


                                 SCHEDULE 13G


                   Under the Securities Exchange Act of 1934
                            (Amendment No. 1 )*




                        PROGENICS PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
                               (Name of Issuer)



                                 COMMON STOCK
- --------------------------------------------------------------------------------
                        (Title of Class of Securities)



                                   743187106
- --------------------------------------------------------------------------------
                                (CUSIP Number)




Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

     [_]  Rule 13d-1(b)

     [_]  Rule 13d-1(c)

     [X]  Rule 13d-1(d)


* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                                    Page 1
<PAGE>

- ----------------------                              
CUSIP No.  743187106                                
- ----------------------                              

- --------------------------------------------------------------------------------

      Names of Reporting Person
 1    S.S. or I.R.S. Identification No. of Above Person

      Tudor Investment Corporation
      22-2514825
- --------------------------------------------------------------------------------

      Check the Appropriate Box if a Member of a Group (See Instructions)
 2                                                                   (a)  [_]
                                                                     (b)  [X]
- --------------------------------------------------------------------------------

      SEC Use Only
 3 
- --------------------------------------------------------------------------------
      Citizenship or Place of Organization  
 4     Delaware

- --------------------------------------------------------------------------------
                          Sole Voting Power                   
NUMBER OF             5
                           0
  SHARES            ------------------------------------------------------------

BENEFICIALLY              Shared Voting Power          
                      6 
                           2,135,165
 OWNED BY            ----------------------------------------------------------
                    
   EACH               7   Sole Dispositive Power            

REPORTING                   0
                      ---------------------------------------------------------
  PERSON
                          Shared Dispositive Power     
   WITH                8
                          2,135,165   
- --------------------------------------------------------------------------------

      Aggregate Amount Beneficially Owned by Each Reporting Person  
 9 
         2,135,165
- --------------------------------------------------------------------------------

 10   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)                                     [_]

- --------------------------------------------------------------------------------
      Percent of Class Represented by Amount in Row 9      
 11 
           22.8%  
- --------------------------------------------------------------------------------

      Type of Reporting Person (See Instructions)   
12 
            CO
- --------------------------------------------------------------------------------

                                    Page 2
<PAGE>

- ----------------------                              
CUSIP No.  743187106                                
- ----------------------                              

- --------------------------------------------------------------------------------

      Names of Reporting Person
 1    S.S. or I.R.S. Identification No. of Above Person

      Tudor Group Holdings LLC    
      13-3862746
- --------------------------------------------------------------------------------

      Check the Appropriate Box if a Member of a Group (See Instructions)
 2                                                                   (a)  [_]
                                                                     (b)  [X]
- --------------------------------------------------------------------------------

      SEC Use Only
 3 
- --------------------------------------------------------------------------------
      Citizenship or Place of Organization  
 4     
      Delaware
- --------------------------------------------------------------------------------
                          Sole Voting Power                   
NUMBER OF             5
                           0
  SHARES            ------------------------------------------------------------

BENEFICIALLY              Shared Voting Power          
                      6 
                           249,149  
 OWNED BY            ----------------------------------------------------------
                    
   EACH               7   Sole Dispositive Power            

REPORTING                   0
                      ---------------------------------------------------------
  PERSON
                          Shared Dispositive Power     
   WITH                8
                          249,149     
- --------------------------------------------------------------------------------

      Aggregate Amount Beneficially Owned by Each Reporting Person  
 9 
         249,149  
- --------------------------------------------------------------------------------

 10   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)                                     [_]

- --------------------------------------------------------------------------------
      Percent of Class Represented by Amount in Row 9      
 11 
           2.7%   
- --------------------------------------------------------------------------------

      Type of Reporting Person (See Instructions)   
12 
            OO
- --------------------------------------------------------------------------------

                                    Page 3


<PAGE>
 
- ----------------------                              
CUSIP No.  743187106                                
- ----------------------                              

- --------------------------------------------------------------------------------

      Names of Reporting Person
 1    S.S. or I.R.S. Identification No. of Above Person

      Paul Tudor Jones, II
- --------------------------------------------------------------------------------

      Check the Appropriate Box if a Member of a Group (See Instructions)
 2                                                                   (a)  [_]
                                                                     (b)  [X]
- --------------------------------------------------------------------------------

      SEC Use Only
 3 
- --------------------------------------------------------------------------------
      Citizenship or Place of Organization  
 4     
      USA
- --------------------------------------------------------------------------------
                          Sole Voting Power                   
NUMBER OF             5
                           546,125
  SHARES            ------------------------------------------------------------

BENEFICIALLY              Shared Voting Power          
                      6 
                           2,384,314
 OWNED BY            ----------------------------------------------------------
                    
   EACH               7   Sole Dispositive Power            

REPORTING                   546,125
                      ---------------------------------------------------------
  PERSON
                          Shared Dispositive Power     
   WITH                8
                          2,384,314   
- --------------------------------------------------------------------------------

      Aggregate Amount Beneficially Owned by Each Reporting Person  
 9 
         2,930,439
- --------------------------------------------------------------------------------

 10   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)                                     [_]

- --------------------------------------------------------------------------------
      Percent of Class Represented by Amount in Row 9      
 11 
           31.2%  
- --------------------------------------------------------------------------------

      Type of Reporting Person (See Instructions)   
12 
            IN
- --------------------------------------------------------------------------------

                                    Page 4

<PAGE>
 
- ----------------------                              
CUSIP No.  743187106                                
- ----------------------                              

- --------------------------------------------------------------------------------

      Names of Reporting Person
 1    S.S. or I.R.S. Identification No. of Above Person

      Mark F. Dalton      
- --------------------------------------------------------------------------------

      Check the Appropriate Box if a Member of a Group (See Instructions)
 2                                                                   (a)  [_]
                                                                     (b)  [X]
- --------------------------------------------------------------------------------

      SEC Use Only
 3 
- --------------------------------------------------------------------------------
      Citizenship or Place of Organization  
 4     
      USA
- --------------------------------------------------------------------------------
                          Sole Voting Power                   
NUMBER OF             5
                           100,500
  SHARES            ------------------------------------------------------------

BENEFICIALLY              Shared Voting Power          
                      6 
                           2,384,314
 OWNED BY            ----------------------------------------------------------
                    
   EACH               7   Sole Dispositive Power            

REPORTING                   100,500
                      ---------------------------------------------------------
  PERSON
                          Shared Dispositive Power     
   WITH                8
                          2,384,314   
- --------------------------------------------------------------------------------

      Aggregate Amount Beneficially Owned by Each Reporting Person  
 9 
         2,484,814
- --------------------------------------------------------------------------------

 10   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)                                     [_]

- --------------------------------------------------------------------------------
       Percent of Class Represented by Amount in Row 9      
 11 
           26.5%  
- --------------------------------------------------------------------------------

       Type of Reporting Person (See Instructions)   
12 
            IN
- --------------------------------------------------------------------------------

                                    Page 5

<PAGE>
 
- ----------------------                              
CUSIP No.  743187106                                
- ----------------------                              

- --------------------------------------------------------------------------------

      Names of Reporting Person
 1    S.S. or I.R.S. Identification No. of Above Person

      Tudor BVI Futures, Ltd.
- --------------------------------------------------------------------------------

      Check the Appropriate Box if a Member of a Group (See Instructions)
 2                                                                   (a)  [_]
                                                                     (b)  [X]
- --------------------------------------------------------------------------------

      SEC Use Only
 3 
- --------------------------------------------------------------------------------
      Citizenship or Place of Organization  
 4     
      British Virgin Islands
- --------------------------------------------------------------------------------
                          Sole Voting Power                   
NUMBER OF             5
                           0
  SHARES            ------------------------------------------------------------

BENEFICIALLY              Shared Voting Power          
                      6 
                           1,847,352 
 OWNED BY            ----------------------------------------------------------
                    
   EACH               7   Sole Dispositive Power            

REPORTING                   0
                      ---------------------------------------------------------
  PERSON
                          Shared Dispositive Power     
   WITH                8
                           1,847,352 
- --------------------------------------------------------------------------------

      Aggregate Amount Beneficially Owned by Each Reporting Person  
 9 
      1,847,352 
- --------------------------------------------------------------------------------

 10   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)                                     [_]

- --------------------------------------------------------------------------------
      Percent of Class Represented by Amount in Row 9      
 11 
           19.7%  
- --------------------------------------------------------------------------------

      Type of Reporting Person (See Instructions)   
12 
            CO
- --------------------------------------------------------------------------------

                                    Page 6


<PAGE>
 
- ----------------------                              
CUSIP No.  743187106                                
- ----------------------                              

- --------------------------------------------------------------------------------

      Names of Reporting Person
 1    S.S. or I.R.S. Identification No. of Above Person

      Tudor Arbitrage Partners L.P.
      13-3496979
- --------------------------------------------------------------------------------

      Check the Appropriate Box if a Member of a Group (See Instructions)
 2                                                                   (a)  [_]
                                                                     (b)  [X]
- --------------------------------------------------------------------------------

      SEC Use Only
 3 
- --------------------------------------------------------------------------------
      Citizenship or Place of Organization  
 4     
      Delaware
- --------------------------------------------------------------------------------
                          Sole Voting Power                   
NUMBER OF             5
                           0
  SHARES            ------------------------------------------------------------

BENEFICIALLY              Shared Voting Power          
                      6 
                          205,624
 OWNED BY            ----------------------------------------------------------
                    
   EACH               7   Sole Dispositive Power            

REPORTING                   0
                      ---------------------------------------------------------
  PERSON
                          Shared Dispositive Power     
   WITH                8
                          205,624
- --------------------------------------------------------------------------------

      Aggregate Amount Beneficially Owned by Each Reporting Person  
 9 
      205,624
- --------------------------------------------------------------------------------

 10   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)                                     [_]

- --------------------------------------------------------------------------------
      Percent of Class Represented by Amount in Row 9      
 11 
           2.2%   
- --------------------------------------------------------------------------------

      Type of Reporting Person (See Instructions)   
12 
            PN
- --------------------------------------------------------------------------------

                                    Page 7


<PAGE>
 
- ----------------------                              
CUSIP No.  743187106                                
- ----------------------                              

- --------------------------------------------------------------------------------

      Names of Reporting Person
 1    S.S. or I.R.S. Identification No. of Above Person

      Tudor Proprietary Trading, L.L.C
      13-3720063
- --------------------------------------------------------------------------------

      Check the Appropriate Box if a Member of a Group (See Instructions)
 2                                                                   (a)  [_]
                                                                     (b)  [X]
- --------------------------------------------------------------------------------

      SEC Use Only
 3 
- --------------------------------------------------------------------------------
      Citizenship or Place of Organization  
 4     
      Delaware
- --------------------------------------------------------------------------------
                          Sole Voting Power                   
NUMBER OF             5
                           0
  SHARES            ------------------------------------------------------------

BENEFICIALLY              Shared Voting Power          
                      6 
                          28,125 
 OWNED BY            ----------------------------------------------------------
                    
   EACH               7   Sole Dispositive Power            

REPORTING                   0
                      ---------------------------------------------------------
  PERSON
                          Shared Dispositive Power     
   WITH                8
                          28,125 
- --------------------------------------------------------------------------------

      Aggregate Amount Beneficially Owned by Each Reporting Person  
 9 
      28,125 
- --------------------------------------------------------------------------------

 10   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)                                     [_]

- --------------------------------------------------------------------------------
      Percent of Class Represented by Amount in Row 9      
 11 
           0.3%   
- --------------------------------------------------------------------------------

      Type of Reporting Person (See Instructions)   
12 
            OO
- --------------------------------------------------------------------------------

                                    Page 8

<PAGE>

- ----------------------                              
CUSIP No.  743187106                                
- ----------------------                              

- --------------------------------------------------------------------------------

      Names of Reporting Person
 1    S.S. or I.R.S. Identification No. of Above Person

      Tudor Global Trading LLC
      13-3862744
- --------------------------------------------------------------------------------

      Check the Appropriate Box if a Member of a Group (See Instructions)
 2                                                                   (a)  [_]
                                                                     (b)  [X]
- --------------------------------------------------------------------------------

      SEC Use Only
 3 
- --------------------------------------------------------------------------------
      Citizenship or Place of Organization  
 4     
      Delaware
- --------------------------------------------------------------------------------
                          Sole Voting Power                   
NUMBER OF             5
                           0
  SHARES            ------------------------------------------------------------

BENEFICIALLY              Shared Voting Power          
                      6 
                          221,024
 OWNED BY            ----------------------------------------------------------
                    
   EACH               7   Sole Dispositive Power            

REPORTING                   0
                      ---------------------------------------------------------
  PERSON
                          Shared Dispositive Power     
   WITH                8
                          221,024
- --------------------------------------------------------------------------------

      Aggregate Amount Beneficially Owned by Each Reporting Person  
 9 
      221,024
- --------------------------------------------------------------------------------

 10   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
        (See Instructions)                                     [_]

- --------------------------------------------------------------------------------
      Percent of Class Represented by Amount in Row 9      
 11 
           2.4%   
- --------------------------------------------------------------------------------

      Type of Reporting Person (See Instructions)   
12 
            OO
- --------------------------------------------------------------------------------

                                    Page 9

 
<PAGE>
 
Item 1(a). Name of Issuer:
          
           Progenics Pharmaceuticals, Inc.
          
Item 1(b). Address of Issuer's Principal Executive Offices:
          
           777 Old Saw Mill River Road
           Tarrytown, NY 10591
          
Item 2(a). Name of Person Filing:
          
           Tudor Investment Corporation ("TIC")
           Tudor Group Holdings LLC ("TGH")
           Paul Tudor Jones, II
           Mark F. Dalton
           Tudor BVI Futures, Ltd. ("Tudor BVI")
           Tudor Arbitrage Partners L.P. ("TAP")
           Tudor Proprietary Trading, L.L.C. ("TPT")
           Tudor Global Trading LLC ("TGT")
          
Item 2(b). Address of Principal Business Office or, if none, Residence:
          
           The principal business office of each of TIC, TGH, TAP, TPT and TGT 
           is:

                           600 Steamboat Road
                           Greenwich, CT 06830

           The principal business office of each of Messrs. Jones and Dalton is:

                           c/o Tudor Investment Corporation
                           600 Steamboat Road
                           Greenwich, CT 06830

           The principal business office of Tudor BVI is:

                           c/o CITCO
                           Kaya Flamboyan 9
                           Curacao, Netherland Antilles

Item 2(c). Citizenship:

           TIC is a Delaware corporation
           Tudor BVI is a company organized under the laws of the British
           Virgin Islands 
           Messrs. Jones and Dalton are citizens of the United States 
           TAP is a Delaware limited partnership 
           TGH, TPT and TGT are Delaware limited liability companies

                                    Page 10
<PAGE>
 
Item 2(d).     Title of Class of Securities:

               Common Stock

Item 2(e).     CUSIP Number:

               743187106

Item 3.        If this statement is filed pursuant to Rules 13d-1(b), or 13d-
               2(b), check whether the person filing is a:

          (a)  [_] Broker or Dealer registered under Section 15 of the Act 
          (b)  [_] Bank as defined in section 3(a)(6) of the Act 
          (c)  [_] Insurance Company as defined in Section 3(a)(19) of the Act 
          (d)  [_] Investment Company registered under Section 8 of the 
                   Investment Company Act
          (e)  [_] Investment Adviser registered under section 203 of the 
                   Investment Advisers Act of 1940
          (f)  [_] Employment Benefit Plan, Pension Fund which is subject to the
                    provisions of the Employee Retirement Income Security Act of
                    1974 or Endowment Fund; see Section 240.13d-1(b)(1)(ii)(F)
          (g)  [_]  Parent Holding Company, in accordance with Section 240.13d-
                    1(b)(1)(ii)(G) (Note: See Item 7)
          (h)  [_]  Group, in accordance with Section 240.13d-1(b)(1)(ii)(H)

                                    Page 11
<PAGE>
 
Item 4.  Ownership (as of December 31, 1998).

         (a)  Amount Beneficially Owned:  See Item 9 of cover pages

         (b)  Percent of Class: See Item 11 of cover pages

         (c)  Number of shares as to which such person has:

              (i)   sole power to vote or to direct the vote See Item 5 of cover
                                                             -------------------
                    pages
                    -----
              (ii)  shared power to vote or to direct the vote See Item 6 of
                                                               -------------
                    cover pages
                    -----------

              (iii) sole power to dispose or to direct the disposition of See 
                                                                          ---
                    Item 7 of cover pages
                    ---------------------
              (iv)  shared power to dispose or to direct the disposition of See
                                                                            ---
                    Item 8 of cover pages
                    ---------------------

         Tudor BVI is the direct beneficial owner of 1,704,501 shares of common
stock ("Shares") and 142,851 warrants ("Warrants" and together with Shares,
"Securities") to purchase Shares. TAP is the direct beneficial owner of 164,499
Shares and 41,125 Warrants. TPT is the direct beneficial owner of 22,500 Shares
and 5,625 Warrants. TGT is the direct beneficial owner of 15,400 Warrants.

         Because TIC provides investment advisory services to Tudor BVI, TIC may
be deemed to beneficially own the Securities owned by Tudor BVI. TIC expressly
disclaims beneficial ownership of such Securities. TGH holds a majority of the
equity interests of TGT and indirectly holds a majority of the membership
interests of TPT. TGH is also the sole limited partner of TAP. TGH expressly
disclaims beneficial ownership of the Securities beneficially owned by each of
such entities. TGT, as the sole general partner of TAP may be deemed to
beneficially own the Securities owned by TAP, and Mr. Dalton, as the sole
general partner of D.F. Partners, a New York limited partnership, may be deemed
to beneficially own the Securities owned by such entity. Each of TGT and Mr.
Dalton expressly disclaim beneficial ownership of such Securities. Mr. Jones is
the Chairman and principal equity owner of TIC and TGH. Mr. Jones expressly
disclaims beneficial ownership of the Securities beneficially owned, or deemed
beneficially owned, by such entities. Mr. Dalton is the President and an equity
owner of TIC and TGH. Mr. Dalton expressly disclaims beneficial ownership of the
Securities beneficially owned, or deemed beneficially owned, by such entities.

         The Shares reported herein under Items 5 and 7 of Mr. Jones' cover page
include 4,600 Shares held directly by Mr. Jones' individual retirement account.


Item 5.  Ownership of Five Percent or Less of a Class.

               Not applicable

                                    Page 12
<PAGE>
 
Item 6.  Ownership of More than Five Percent on Behalf of Another Person.

               Not applicable

Item 7.  Identification and Classification of the Subsidiary Which Acquired the
         Security Being Reported on By the Parents Holding Company.

               Not applicable

Item 8.  Identification and Classification of Members of the Group.

               See cover pages

Item 9.  Notice of Dissolution of Group.

               Not applicable

                                    Page 13
<PAGE>
 
Item 10.  Certification.

               Not applicable

               After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.


                                     Dated: February 11, 1999

                                     TUDOR INVESTMENT CORPORATION


                                     By:    /s/ Andrew S. Paul 
                                         ---------------------------------------
                                         Andrew S. Paul
                                         Managing Director and General Counsel

                                     TUDOR GROUP HOLDINGS LLC


                                     By:    /s/ Andrew S. Paul    
                                         ---------------------------------------
                                         Andrew S. Paul
                                         Managing Director and General Counsel


                                     
                                         /s/ Paul Tudor Jones, II 
                                     -------------------------------------------
                                         Paul Tudor Jones, II



                                         /s/ Mark F. Dalton  
                                     -------------------------------------------
                                         Mark F. Dalton

                                     TUDOR BVI FUTURES, LTD.

                                     By: Tudor Investment Corporation,
                                         Trading Advisor


                                         By:    /s/ Andrew S. Paul  
                                             -----------------------------------
                                             Andrew S. Paul
                                             Managing Director and General
                                             Counsel

                                    Page 14
<PAGE>
 
                                     TUDOR ARBITRAGE PARTNERS L.P.

                                     By: Tudor Global Trading LLC,
                                         General Partner


                                         By:    /s/ Andrew S. Paul  
                                              ----------------------------------
                                              Andrew S. Paul
                                              Managing Director and General
                                              Counsel

                                     TUDOR PROPRIETARY TRADING, L.L.C.


                                     By:   /s/ Andrew S. Paul 
                                         ---------------------------------------
                                         Andrew S. Paul
                                         Managing Director and General 
                                         Counsel

                                     TUDOR GLOBAL TRADING LLC


                                     By:   /s/ Andrew S. Paul 
                                         ---------------------------------------
                                         Andrew S. Paul
                                         Managing Director and General Counsel

                                    Page 15


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