MORGAN STANLEY INSTITUTIONAL FUND INC
497, 1996-05-03
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<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
   -------------------------------------------------------------------------
 
                            GLOBAL EQUITY PORTFOLIO
                         INTERNATIONAL EQUITY PORTFOLIO
                       INTERNATIONAL SMALL CAP PORTFOLIO
                             ASIAN EQUITY PORTFOLIO
                           EUROPEAN EQUITY PORTFOLIO
                           JAPANESE EQUITY PORTFOLIO
                            LATIN AMERICAN PORTFOLIO
 
                               PORTFOLIOS OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
                                ----------------
 
    Morgan  Stanley Institutional Fund, Inc (the  "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a   series   of   diversified   and   non-diversified   investment    portfolios
("portfolios").   The  Fund   currently  consists   of  twenty-eight  portfolios
representing a  broad range  of  investment choices.  The  Fund is  designed  to
provide clients with attractive alternatives for meeting their investment needs.
This  prospectus (the  "Prospectus") pertains  to the  Class A  and the  Class B
shares of  the  Global  Equity, International  Equity,  Asian  Equity,  European
Equity,   Japanese  Equity  and  Latin   American  Portfolios  (the  "Multiclass
Portfolios") and to the Class A Shares of the International Small Cap  Portfolio
(collectively,  the "Portfolios"). On January 2, 1996, the Multiclass Portfolios
began offering two classes of shares, the Class A shares and the Class B shares,
except for the Money Market, Municipal Money Market and International Small  Cap
Portfolios  which only offer Class A shares.  All shares of the Portfolios owned
prior to January 2, 1996  were redesignated Class A  shares on January 2,  1996.
The International Equity Portfolio is currently closed to new investors with the
exception  of certain Morgan Stanley  customers. The Class A  and Class B shares
currently  offered  by   the  Portfolios  have   different  minimum   investment
requirements  and fund  expenses. Shares of  the portfolios are  offered with no
sales  charge  or  exchange  or  redemption  fee  (with  the  exception  of  the
International Small Cap Portfolio).
 
    The   GLOBAL  EQUITY  PORTFOLIO  seeks  long-term  capital  appreciation  by
investing primarily  in  equity  securities of  issuers  throughout  the  world,
including U.S. issuers.
 
    The  INTERNATIONAL EQUITY PORTFOLIO seeks  long-term capital appreciation by
investing primarily in equity securities of non-U.S. issuers.
 
    The INTERNATIONAL SMALL CAP  PORTFOLIO seeks long-term capital  appreciation
by  investing primarily  in equity  securities of  non-U.S. issuers  with equity
market capitalizations of less than $1 billion.
 
    The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by investing
primarily in equity securities of Asian issuers.
 
    The EUROPEAN  EQUITY  PORTFOLIO  seeks  long-term  capital  appreciation  by
investing primarily in equity securities of European issuers.
 
    The  JAPANESE EQUITY PORTFOLIO seeks  long-term capital appreciation through
investment in equity securities of Japanese issuers.
 
    The  LATIN  AMERICAN  PORTFOLIO  seeks  long-term  capital  appreciation  by
investing  primarily in equity securities of  Latin American issuers and in debt
securities issued or  guaranteed by Latin  American governments or  governmental
entities.
 
    INVESTORS  SHOULD NOTE THAT EACH PORTFOLIO MAY INVEST UP TO 10% OF ITS TOTAL
ASSETS IN  RESTRICTED SECURITIES,  AND  THE INTERNATIONAL  SMALL CAP  AND  LATIN
AMERICAN  PORTFOLIOS MAY INVEST  UP TO 25%  OF THEIR RESPECTIVE  TOTAL ASSETS IN
RESTRICTED SECURITIES THAT ARE RULE 144A SECURITIES. SEE "ADDITIONAL  INVESTMENT
INFORMATION -- NON-PUBLICLY TRADED SECURITIES, PRIVATE PLACEMENTS AND RESTRICTED
SECURITIES."  INVESTMENTS  IN  RESTRICTED  SECURITIES  IN  EXCESS  OF  5%  OF  A
PORTFOLIO'S TOTAL ASSETS MAY BE  CONSIDERED A SPECULATIVE ACTIVITY, MAY  INVOLVE
GREATER RISK AND MAY INCREASE THE PORTFOLIO'S EXPENSES.
 
    The  Fund is designed  to meet the investment  needs of discerning investors
who place a premium on quality  and personal service. With Morgan Stanley  Asset
Management   Inc.  as   Adviser  and   Administrator  (the   "Adviser"  and  the
"Administrator"), and with Morgan Stanley & Co. Incorporated ("Morgan  Stanley")
as  Distributor, the  Fund makes available  to institutional and  high net worth
individual investors a series  of portfolios which  benefit from the  investment
expertise  and commitment to  excellence associated with  Morgan Stanley and its
affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should  know before investing and it should  be
retained  for future reference. The Fund  offers additional portfolios which are
described in other prospectuses and  under "Prospectus Summary" below. The  Fund
currently  offers the following portfolios:  (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian  Equity, Emerging Markets, European  Equity,
Global  Equity, Gold, International  Equity, International Magnum, International
Small Cap, Japanese Equity  and Latin American Portfolios;  (ii) U.S. EQUITY  --
Aggressive  Equity, Emerging  Growth, Equity  Growth, MicroCap,  Small Cap Value
Equity, U.S. Real  Estate and Value  Equity Portfolios; (iii)  EQUITY AND  FIXED
INCOME  -- Balanced Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed
Income,  Global  Fixed  Income,  High  Yield,  Mortgage-Backed  Securities   and
Municipal  Bond Portfolios; and  (v) MONEY MARKET --  Money Market and Municipal
Money Market Portfolios. Additional information about the Fund is contained in a
"Statement of Additional Information," dated May 1, 1996, which is  incorporated
herein   by  reference.  The   Statement  of  Additional   Information  and  the
prospectuses pertaining to the other portfolios  of the Fund are available  upon
request  and without charge  by writing or  calling the Fund  at the address and
telephone number set forth above.
 
 THESE SECURITIES  HAVE NOT  BEEN  APPROVED OR  DISAPPROVED BY  THE  SECURITIES
   AND  EXCHANGE COMMISSION OR  ANY STATE SECURITIES  COMMISSION, NOR HAS THE
    SECURITIES AND EXCHANGE  COMMISSION OR ANY  STATE SECURITIES  COMMISSION
     PASSED   UPON  THE  ACCURACY  OR  ADEQUACY  OF  THIS  PROSPECTUS.  ANY
             REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
                  THE DATE OF THIS PROSPECTUS IS MAY 1, 1996.
<PAGE>
                                 FUND EXPENSES
 
    The  following table illustrates the expenses and fees that a shareholder of
each Portfolio listed below will incur.
<TABLE>
<CAPTION>
                                                GLOBAL EQUITY   INTERNATIONAL EQUITY   INTERNATIONAL SMALL    ASIAN EQUITY
SHAREHOLDER TRANSACTION EXPENSES                  PORTFOLIO           PORTFOLIO           CAP PORTFOLIO         PORTFOLIO
- ---------------------------------------------  ---------------  ---------------------  -------------------  -----------------
<S>                                            <C>              <C>                    <C>                  <C>
Maximum Sales Load Imposed on Purchases
  Class A....................................          None                None                  None*               None
  Class B....................................          None                None                  None*               None
Maximum Sales Load Imposed on Reinvested
 Dividends
  Class A....................................          None                None                  None                None
  Class B....................................          None                None                   N/A                None
Deferred Sales Load
  Class A....................................          None                None                  None                None
  Class B....................................          None                None                   N/A                None
Redemption Fees
  Class A....................................          None                None                  1.00%*              None
  Class B....................................          None                None                  1.00%*              None
Exchange Fees
  Class A....................................          None                None                  None                None
  Class B....................................          None                None                   N/A                None
 
<CAPTION>
 
                                                                   EUROPEAN EQUITY       JAPANESE EQUITY     LATIN AMERICAN
SHAREHOLDER TRANSACTION EXPENSES                                      PORTFOLIO             PORTFOLIO           PORTFOLIO
- ---------------------------------------------                   ---------------------  -------------------  -----------------
<S>                                            <C>              <C>                    <C>                  <C>
Maximum Sales Load Imposed on Purchases
  Class A.....................................................             None                  None                None
  Class B.....................................................             None                  None                None
Maximum Sales Load Imposed on Reinvested Dividends
  Class A.....................................................             None                  None                None
  Class B.....................................................             None                  None                None
Deferred Sales Load
  Class A.....................................................             None                  None                None
  Class B.....................................................             None                  None                None
Redemption Fees
  Class A.....................................................             None                  None                None
  Class B.....................................................             None                  None                None
Exchange Fees
  Class A.....................................................             None                  None                None
  Class B.....................................................             None                  None                None
</TABLE>
 
- --------------------------
* Shareholders of  the International  Small Cap  Portfolio are  charged a  1.00%
  transaction  fee, which  is payable  directly to  the International  Small Cap
  Portfolio, in connection with  each purchase and redemption  of shares of  the
  Portfolio.  The  transaction fee  is  intended to  allocate  transaction costs
  associated with  purchases  and redemptions  of  shares of  the  Portfolio  to
  investors  actually making such  purchases and redemptions  rather than to the
  Portfolio's  other  shareholders.  The  1.00%  fee  represents  the  Adviser's
  estimate  of such transaction costs, which  include the costs of acquiring and
  disposing of Portfolio securities. The transaction  fee is not a sales  charge
  or  load,  and  is  retained by  the  Portfolio.  The fee  does  not  apply to
  Portfolios of the Fund other than the International Small Cap Portfolio and is
  not charged in
 
                                       2
<PAGE>
  connection with the reinvestment of  dividends or capital gain  distributions.
  The  fee will not be charged with respect to purchases and redemptions that do
  not result in  actual transaction  costs to  the Portfolio.  Examples of  such
  transactions   include  offsetting  purchases  and  redemptions  by  different
  shareholders occurring at the same time and in-kind purchases and redemptions.
<TABLE>
<CAPTION>
                                                                    INTERNATIONAL
                                                  GLOBAL EQUITY        EQUITY         INTERNATIONAL SMALL   ASIAN EQUITY
ANNUAL FUND OPERATING EXPENSES                      PORTFOLIO         PORTFOLIO          CAP PORTFOLIO       PORTFOLIO
- ------------------------------------------------  -------------  -------------------  -------------------  --------------
 (AS A PERCENTAGE OF AVERAGE NET ASSETS)
<S>                                               <C>            <C>                  <C>                  <C>
Management Fee (Net of Fee Waivers)***
  Class A.......................................        0.67%             0.77%                0.86%              0.62%
  Class B.......................................        0.67%             0.77%                  N/A              0.62%
12b-1 Fees
  Class A.......................................         None              None                 None               None
  Class B.......................................        0.25%             0.25%                  N/A              0.25%
Other Expenses
  Class A.......................................        0.33%             0.23%                0.29%              0.38%
  Class B.......................................        0.33%             0.23%                  N/A              0.38%
                                                  -------------         -------              -------       --------------
Total Operating Expenses (Net of Fee Waivers)*
  Class A.......................................        1.00%             1.00%                1.15%              1.00%
  Class B.......................................        1.25%             1.25%                  N/A              1.25%
                                                  -------------         -------              -------       --------------
                                                  -------------         -------              -------       --------------
 
<CAPTION>
 
                                                                   EUROPEAN EQUITY      JAPANESE EQUITY    LATIN AMERICAN
ANNUAL FUND OPERATING EXPENSES                                        PORTFOLIO            PORTFOLIO         PORTFOLIO
- ------------------------------------------------                 -------------------  -------------------  --------------
 (AS A PERCENTAGE OF AVERAGE NET ASSETS)
<S>                                               <C>            <C>                  <C>                  <C>
Management Fee (Net of Fee Waivers)***
  Class A......................................................           0.55%                0.60%              0.00%
  Class B......................................................           0.55%                0.60%              0.00%
12b-1 Fees
  Class A......................................................            None                 None               None
  Class B......................................................           0.25%                0.25%              0.25%
Other Expenses
  Class A......................................................           0.45%                0.40%              1.70%**
  Class B......................................................           0.45%                0.40%              1.70%**
                                                                        -------              -------       --------------
Total Operating Expenses (Net of Fee Waivers)
  Class A......................................................           1.00%                1.00%              1.70%**
  Class B......................................................           1.25%                1.25%              1.95%**
                                                                        -------              -------       --------------
                                                                        -------
</TABLE>
 
- --------------------------
  * "Other Expenses" for the Latin American Portfolio includes an annual fee  of
    0.125%   of  the  Portfolios'  average  weekly  net  assets  paid  to  local
    administrators  required  under  Brazilian  and  Chilean  law.  See   "Local
    Administrators for the Latin American Portfolio".
 
 ** Annualized.
 
*** The  Adviser has agreed  to waive its management  fees and/or reimburse each
    Portfolio, if necessary, if  such fees would cause  any of the total  annual
    operating  expenses of  the Portfolios to  exceed a  specified percentage of
    their respective average daily net assets. Set forth
 
                                       3
<PAGE>
    below, for each Portfolio as applicable,  are the management fees and  total
    operating  expenses absent such fee waivers and/or expense reimbursements as
    a percent  of  average  daily net  assets  of  the Class  A  shares  of  the
    Portfolios and Class B Shares of the Multiclass Portfolios, respectively.
 
<TABLE>
<CAPTION>
                                                                                     TOTAL OPERATING EXPENSES
                                                                                        ABSENT FEE WAIVERS
                                                                     MANAGEMENT
                                                                  FEES ABSENT FEE   --------------------------
PORTFOLIO                                                             WAIVERS         CLASS A       CLASS B+
- ----------------------------------------------------------------  ----------------  ------------  ------------
<S>                                                               <C>               <C>           <C>
Global Equity...................................................          0.80%           1.13%         1.38%
International Equity............................................          0.80%           1.03%         1.28%
International Small Cap.........................................          0.95%           1.24%          N/A
Asian Equity....................................................          0.80%           1.18%         1.43%
European Equity.................................................          0.80%           1.25%         1.50%
Japanese Equity.................................................          0.80%           1.20%         1.45%
Latin American..................................................          1.10%           3.13%++       3.38%++
</TABLE>
 
- ------------------------------
 + Estimated.
 
++ Annualized.
   These  reductions became  effective as  of the  inception of  each Portfolio,
   except with respect to  the International Equity Portfolio,  as to which  the
   effective  date was February 15,  1990. As a result  of these reductions, the
   Management Fees stated above are lower than the contractual fees stated under
   "Management of  the Fund."  For  further information  on Fund  expenses,  see
   "Management of the Fund."
 
    The  purpose of  the table  is to assist  the investor  in understanding the
various expenses  that an  investor  in the  Portfolios  will bear  directly  or
indirectly.  The Class A  expenses and fees  for Portfolios are  based on actual
figures for the fiscal year  ended December 31, 1995.  The Class B expenses  and
fees  for the  Multiclass Portfolios  are based  on estimates  assuming that the
average daily net assets of the Class B shares of each Multiclass Portfolio will
be $50,000,000. "Other Expenses" include Board of Directors' fees and  expenses,
amortization  or organizational costs, filing  fees, professional fees and costs
for shareholder reports. Due to the  continuous nature of Rule 12b-1 fees,  long
term  Class  B shareholders  may pay  more  than the  equivalent of  the maximum
front-end sales charges otherwise permitted by the Rules of Fair Practice of the
National Association of Securities Dealers, Inc. ("NASD").
 
                                       4
<PAGE>
    The following  example illustrates  the expenses  that you  would pay  on  a
$1,000 investment assuming (1) a 5% rate of return and (2) redemption at the end
of  each time  period. As  noted above, the  only fee  charged by  the Fund upon
purchase or redemption  of Fund  shares is the  1% transaction  fee assessed  on
purchases  and redemptions of  shares of the  International Small Cap Portfolio,
which charges  are reflected  in this  example. The  example is  based on  total
operating expenses of the Portfolios after fee waivers.
 
<TABLE>
<CAPTION>
                                               3       5       10
                                     1 YEAR  YEARS   YEARS    YEARS
                                     ------  ------  ------  -------
<S>                                  <C>     <C>     <C>     <C>
Global Equity Portfolio
  Class A..........................  $  10   $  32   $  55   $  122
  Class B..........................     13      40      69      151
International Equity Portfolio
  Class A..........................     10      32      55      122
  Class B..........................     13      40      69      151
International Small Cap Portfolio
  Class A..........................     32      57      85      163
Asian Equity Portfolio
  Class A..........................     10      32      55      122
  Class B..........................     13      40      69      151
European Equity Portfolio
  Class A..........................     10      32      55      122
  Class B..........................     13      40      69      151
Japanese Equity Portfolio
  Class A..........................     10      32      55      122
  Class B..........................     13      40      69      151
Latin American Portfolio
  Class A..........................     17      54      92      201
  Class B..........................     20      61     105      227
</TABLE>
 
    THIS  EXAMPLE SHOULD  NOT BE CONSIDERED  A REPRESENTATION OF  PAST OR FUTURE
EXPENSES OR  PERFORMANCE. ACTUAL  EXPENSES MAY  BE GREATER  OR LESS  THAN  THOSE
SHOWN.
 
    The  Fund intends to  continue to comply  with all state  laws that restrict
investment company expenses. Currently, the most restrictive state law  requires
that the aggregate annual expenses of an investment company shall not exceed two
and  one-half percent (2 1/2%)  of the first $30  million of average net assets,
two percent (2%)  of the next  $70 million of  average net assets,  and one  and
one-half  percent  (1  1/2%) of  the  remaining  net assets  of  such investment
company.
 
    The Adviser has agreed to a reduction  in the amounts payable to it, and  to
reimburse  any Portfolio,  if necessary, if  in any  fiscal year the  sum of the
Portfolio's expenses exceeds the limit set by applicable state law.
 
                                       5
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following table provides financial highlights for the Class A shares  of
the  Portfolios  for  each  of  the  periods  presented.  The  audited financial
highlights for the Class A  shares for the fiscal  year ended December 31,  1995
are  part of the Fund's financial statements which appear in the Fund's December
31, 1995 Annual  Report to  Shareholders and which  are included  in the  Fund's
Statement  of Additional  Information. The Portfolios'  financial highlights for
each of the periods in the five years ended December 31, 1995 have been  audited
by  Price Waterhouse, LLP, whose unqualified  report thereon is also included in
the Statement of Additional Information. Additional performance information  for
the  Class A shares is included in the  Annual Report. The Annual Report and the
financial  statements   therein,  along   with  the   Statement  of   Additional
Information, are available at no cost from the Fund at the address and telephone
number  noted on the cover page of this Prospectus. Financial highlights are not
available for the new Class B shares since they were not offered as of  December
31,  1995. Subsequent to October 31, 1992 (the Fund's prior fiscal year end) the
Fund changed  its fiscal  year end  to December  31. The  following  information
should be read in conjunction with the financial statements and notes thereto.
 
                                       6
<PAGE>
                            GLOBAL EQUITY PORTFOLIO
 
<TABLE>
<CAPTION>
                                                   JULY 15,     TWO MONTHS
                                                   1992* TO        ENDED       YEAR ENDED     YEAR ENDED     YEAR ENDED
                                                  OCTOBER 31,  DECEMBER 31,   DECEMBER 31,   DECEMBER 31,   DECEMBER 31,
                                                     1992          1992           1993           1994           1995
                                                  -----------  -------------  -------------  -------------  -------------
<S>                                               <C>          <C>            <C>            <C>            <C>
NET ASSET VALUE, BEGINNING OF PERIOD............   $   10.00     $    9.35      $    9.75      $   13.87      $   13.40
                                                  -----------  -------------  -------------  -------------  -------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)(2)..................        0.02          0.01           0.08           0.08           0.18
  Net Realized and Unrealized Gain/(Loss) on
   Investments..................................       (0.67)         0.39           4.18           0.79           2.26
                                                  -----------  -------------  -------------  -------------  -------------
  Total from Investment Operations..............       (0.65)         0.40           4.26           0.87           2.44
                                                  -----------  -------------  -------------  -------------  -------------
DISTRIBUTIONS
  Net Investment Income.........................          --            --          (0.02)         (0.12)         (0.22)
  In Excess of Net Investment Income............          --            --          (0.03)            --             --
  Net Realized Gain.............................          --            --          (0.09)         (1.22)         (1.31)
                                                  -----------  -------------  -------------  -------------  -------------
Total Distributions.............................          --            --          (0.14)         (1.34)         (1.53)
                                                  -----------  -------------  -------------  -------------  -------------
NET ASSET VALUE, END OF PERIOD..................   $    9.35     $    9.75      $   13.87      $   13.40      $   14.31
                                                  -----------  -------------  -------------  -------------  -------------
                                                  -----------  -------------  -------------  -------------  -------------
TOTAL RETURN....................................       (6.50)%        4.28%         44.24%          6.95%         18.66%
                                                  -----------  -------------  -------------  -------------  -------------
                                                  -----------  -------------  -------------  -------------  -------------
RATIOS AND SUPPLEMENTAL DATA:
Net Assets, End of Period (Thousands)...........   $  11,257     $  11,739      $  19,918      $  78,935      $  91,675
Ratio of Expenses to Average Net Assets
 (1)(2).........................................        1.00%**        1.00%**        1.00%         1.00%          1.00%
Ratio of Net Investment Income to Average Net
 Assets (1).....................................        1.00%**        0.69%**        0.84%         0.87%          1.17%
Portfolio Turnover Rate.........................          10%            5%            42%            12%            28%
</TABLE>
 
- ------------------------------
 
<TABLE>
<S> <C>                                                 <C>         <C>         <C>         <C>         <C>
(1) Effect of voluntary expense limitation during the period:
    Per share benefit to net investment income........  $  0.08     $  0.02     $  0.01     $  0.02     $  0.02
    Ratios before expense limitation:
    Expenses to Average Net Assets....................     5.22%**     2.49%**     1.66%       1.24%       1.13%
    Net Investment Income (Loss) to Average
       Net Assets.....................................    (3.22)%**   (0.80)%**    0.18%       0.63%       1.04%
</TABLE>
 
(2) Under the terms of an Investment Advisory Agreement, the Adviser is entitled
    to  receive a management  fee calculated at  an annual rate  of 0.80% of the
    average daily net  assets of the  Global Equity Portfolio.  The Adviser  has
    agreed  to waive  a portion  of this  fee and/or  reimburse expenses  of the
    Portfolio to the extent that the  total operating expenses of the  Portfolio
    exceed 1.00% of the average daily net assets of the Class A shares and 1.25%
    of  the average daily net assets of the Class B shares. In the fiscal period
    ended October 31,  1992, the  two months ended  December 31,  1992, and  the
    years  ended December 31, 1993, 1994 and 1995, the Adviser waived management
    fees  and/or  reimbursed  expenses  totalling  $97,000,  $28,000,  $101,000,
    $126,000 and $109,000, respectively, for the Global Equity Portfolio.
 
 * Commencement of Operations.
 
** Annualized.
 
                                       7
<PAGE>
                         INTERNATIONAL EQUITY PORTFOLIO
<TABLE>
<CAPTION>
                                                                                                             TWO
                                                      AUGUST 4,                                            MONTHS        YEAR
                                                      1989* TO       YEAR         YEAR         YEAR         ENDED        ENDED
                                                        OCTO-     ENDED OCTO-  ENDED OCTO-  ENDED OCTO-    DECEM-       DECEM-
                                                       BER 31,      BER 31,      BER 31,      BER 31,      BER 31,      BER 31,
                                                        1989         1990         1991         1992         1992         1993
                                                     -----------  -----------  -----------  -----------  -----------  -----------
<S>                                                  <C>          <C>          <C>          <C>          <C>          <C>
NET ASSET VALUE, BEGINNING OF PERIOD...............   $   10.00    $    9.72    $   10.05    $   10.52    $    9.83    $    9.98
                                                     -----------  -----------  -----------  -----------  -----------  -----------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income............................        0.05         0.19         0.12         0.12         0.01         0.15
  Net Realized and Unrealized Gain/(Loss) on
   Investments.....................................       (0.33)        0.20         0.58        (0.59)        0.14         4.36
                                                     -----------  -----------  -----------  -----------  -----------  -----------
  Total from Investment Operations.................       (0.28)        0.39         0.70        (0.47)        0.15         4.51
                                                     -----------  -----------  -----------  -----------  -----------  -----------
DISTRIBUTIONS
  Net Investment Income............................          --        (0.06)       (0.15)       (0.17)          --        (0.01)
  In Excess of Net Investment Income...............          --           --           --           --           --        (0.13)
  Net Realized Gain................................          --           --        (0.08)       (0.05)          --        (0.26)
                                                     -----------  -----------  -----------  -----------  -----------  -----------
Total Distributions................................          --        (0.06)       (0.23)       (0.22)          --        (0.40)
                                                     -----------  -----------  -----------  -----------  -----------  -----------
NET ASSET VALUE, END OF PERIOD.....................   $    9.72    $   10.05    $   10.52    $    9.83    $    9.98    $   14.09
                                                     -----------  -----------  -----------  -----------  -----------  -----------
                                                     -----------  -----------  -----------  -----------  -----------  -----------
TOTAL RETURN.......................................       (2.80)%       3.99%        7.17%       (4.56)%       1.53%       46.50%
                                                     -----------  -----------  -----------  -----------  -----------  -----------
                                                     -----------  -----------  -----------  -----------  -----------  -----------
RATIOS AND SUPPLEMENTAL DATA:
Net Assets, End of Period (Thousands)..............   $   7,811    $ 110,716    $ 283,776    $ 486,836    $ 510,727    $ 947,045
Ratio of Expenses to Average Net
 Assets (1)(2).....................................        1.35%**       1.03%       1.00%        1.00%        1.00%**       1.00%
Ratio of Net Investment Income to Average Net
 Assets (1)(2).....................................        2.34%        3.51%        2.27%        1.46%        0.68%**       1.25%
Portfolio Turnover Rate............................           0%          38%          22%          12%           5%          23%
 
<CAPTION>
 
                                                         YEAR          YEAR
                                                     ENDED DECEM-  ENDED DECEM-
                                                       BER 31,       BER 31,
                                                         1994          1995
                                                     ------------  ------------
<S>                                                  <C>           <C>
NET ASSET VALUE, BEGINNING OF PERIOD...............   $    14.09    $    15.34
                                                     ------------  ------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income............................         0.16          0.16
  Net Realized and Unrealized Gain/(Loss) on
   Investments.....................................         1.54          1.55
                                                     ------------  ------------
  Total from Investment Operations.................         1.70          1.71
                                                     ------------  ------------
DISTRIBUTIONS
  Net Investment Income............................        (0.18)        (0.06)
  In Excess of Net Investment Income...............           --            --
  Net Realized Gain................................        (0.27)        (1.84)
                                                     ------------  ------------
Total Distributions................................        (0.45)        (1.90)
                                                     ------------  ------------
NET ASSET VALUE, END OF PERIOD.....................   $    15.34    $    15.15
                                                     ------------  ------------
                                                     ------------  ------------
TOTAL RETURN.......................................        12.39%        11.77%
                                                     ------------  ------------
                                                     ------------  ------------
RATIOS AND SUPPLEMENTAL DATA:
Net Assets, End of Period (Thousands)..............   $1,304,770    $1,598,503
Ratio of Expenses to Average Net
 Assets (1)(2).....................................         1.00%         1.00%
Ratio of Net Investment Income to Average Net
 Assets (1)(2).....................................         1.12%         1.38%
Portfolio Turnover Rate............................           16%           27%
</TABLE>
 
- ------------------------
<TABLE>
<S>                                           <C>          <C>          <C>          <C>          <C>          <C>
(1) Effect of voluntary expense limitation during the period:
      Per share benefit to net investment
       income...............................   $    0.00+   $    0.01    $    0.01    $    0.00+   $    0.00+   $    0.01
   Ratios before expense limitation:
      Expenses to Average Net Assets........        2.58%**       1.24%       1.09%        1.02%        1.14%**       1.06%
      Net Investment Income to Average Net
       Assets...............................        1.11%**       3.30%       2.18%        1.44%        0.54%**       1.19%
 
<CAPTION>
(1) Effect of voluntary expense limitation d
<S>                                           <C>          <C>
      Per share benefit to net investment
       income...............................   $   0.004    $   0.003
   Ratios before expense limitation:
      Expenses to Average Net Assets........        1.03%        1.03%
      Net Investment Income to Average Net
       Assets...............................        1.09%        1.35%
</TABLE>
 
 + Per share benefit to net investment income is less than $0.0001.
 
(2)Under  the terms of an Investment Advisory Agreement, the Adviser is entitled
   to receive a  management fee calculated  at an  annual rate of  0.80% of  the
   average  daily net assets of the  International Equity Portfolio. The Adviser
   has agreed to waive a  portion of this fee  and/or reimburse expenses of  the
   Portfolio  to the extent  that the total operating  expenses of the Portfolio
   exceed 1.00% of the average daily net assets of the Class A shares and  1.25%
   of  the average  daily net assets  of the Class  B shares. In  the year ended
   October 31,  1991, the  year ended  October 31,  1992, the  two months  ended
   December  31, 1992, and the years ended December 31, 1993, 1994 and 1995, the
   Adviser waived management fees and/or reimbursed expenses totaling  $147,000,
   $78,000,  $116,000, $405,000,  $344,000 and  $424,000, respectively,  for the
   International Equity Portfolio.
 
 * Commencement of Operations.
 
** Annualized.
 
                                       8
<PAGE>
                       INTERNATIONAL SMALL CAP PORTFOLIO
 
<TABLE>
<CAPTION>
                                               DECEMBER 15,
                                                 1992* TO       YEAR ENDED      YEAR ENDED      YEAR ENDED
                                               DECEMBER 31,    DECEMBER 31,    DECEMBER 31,    DECEMBER 31,
                                                   1992            1993+           1994            1995
                                               -------------   -------------   -------------   -------------
<S>                                            <C>             <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........  $   10.00       $   10.09       $   14.64       $   15.15
                                                  ------       -------------   -------------   -------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)(3)...............       0.01            0.09            0.14            0.24
  Net Realized and Unrealized Gain on
   Investments (2)...........................       0.08            4.48            0.62            0.15
                                                  ------       -------------   -------------   -------------
  Total from Investment Operations...........       0.09            4.57            0.76            0.39
                                                  ------       -------------   -------------   -------------
DISTRIBUTIONS
  Net Investment Income......................         --            0.00           (0.03)          (0.23)
  In Excess of Net Investment Income.........         --           (0.02)             --              --
  Net Realized Gain..........................         --              --           (0.22)          (0.37)
Total Distributions..........................         --           (0.02)          (0.25)          (0.60)
                                                  ------       -------------   -------------   -------------
NET ASSET VALUE, END OF PERIOD                 $   10.09       $   14.64       $   15.15       $   14.94
                                                  ------       -------------   -------------   -------------
                                                  ------       -------------   -------------   -------------
TOTAL RETURN.................................       0.90%          45.34%           5.25%           2.60%
                                                  ------       -------------   -------------   -------------
                                                  ------       -------------   -------------   -------------
RATIOS AND SUPPLEMENTAL DATA:
Net Assets, End of Period (Thousands)........  $   3,824       $  52,834       $ 160,101       $ 198,669
Ratio of Expenses to Average Net Assets
 (1)(3)......................................       1.15%**         1.15%           1.15%           1.15%
Ratio of Net Investment Income to
 Average Net Assets (1)(3)...................       1.37%**         0.66%           1.18%           1.72%
Portfolio Turnover Rate......................          0%             14%              8%             24%
</TABLE>
 
- ------------------------------
 
<TABLE>
<S> <C>                                        <C>             <C>             <C>             <C>
(1) Effect of voluntary expense limitation during the
     period:
    Per share benefit to net investment
     income..................................  $    0.16       $    0.10       $    0.02       $    0.01
    Ratios before expense limitation:
    Expenses to Average Net Assets...........      21.67%**         1.86%           1.29%           1.24%
    Net Investment Income/(Loss) to Average
     Net Assets..............................     (19.15)%**       (0.05)%          1.04%           1.63%
</TABLE>
 
(2) Includes a  1%  transaction fee  on  purchases and  redemptions  of  capital
    shares.
 
(3) Under the terms of an Investment Advisory Agreement, the Adviser is entitled
    to  receive a management  fee calculated at  an annual rate  of 0.95% of the
    average daily net assets of the Class A shares of the Portfolio. The Adviser
    has agreed to waive a portion of  this fee and/or reimburse expenses of  the
    Portfolio  to the extent that the  total operating expenses of the Portfolio
    exceed 1.15% of the average  daily net assets of the  Class A shares of  the
    Portfolio.  In  the period  ended  December 31,  1992,  and the  years ended
    December 31, 1993, 1994 and 1995, the Adviser waived management fees  and/or
    reimbursed  expenses  totaling  $32,000,  $151,000,  $174,000  and $181,000,
    respectively, for the International Small Cap Portfolio.
 
 * Commencement of Operations.
 
** Annualized.
 
 + Per share amounts for the year ended  December 31, 1993 are based on  average
   outstanding shares.
 
                                       9
<PAGE>
                             ASIAN EQUITY PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                          TWO
                                                JULY 1,      YEAR       MONTHS       YEAR        YEAR        YEAR
                                               1991, TO      ENDED       ENDED       ENDED       ENDED       ENDED
                                                OCTOBER     OCTOBER    DECEMBER    DECEMBER    DECEMBER    DECEMBER
                                               31, 1991    31, 1992    31, 1992    31, 1993    31, 1994    31, 1995
                                               ---------   ---------   ---------   ---------   ---------   ---------
<S>                                            <C>         <C>         <C>         <C>         <C>         <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........  $ 10.00     $  9.67     $ 13.63     $ 13.11     $ 26.20     $ 21.54
                                               ---------   ---------   ---------   ---------   ---------   ---------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)(2)...............     0.03        0.14        0.01        0.10        0.11        0.18
  Net Realized and Unrealized Gain/(Loss) on
   Investments...............................    (0.36)       3.86       (0.53)      13.38       (4.15)       1.11
                                               ---------   ---------   ---------   ---------   ---------   ---------
  Total from Investment Operations...........   (0.33)        4.00      (0.52)       13.48      (4.04)        1.29
                                               ---------   ---------   ---------   ---------   ---------   ---------
DISTRIBUTIONS
  Net Investment Income......................       --       (0.04)         --       (0.01)      (0.09)      (0.34)
  In Excess of Net Investment Income.........       --          --          --       (0.13)         --       (0.00)+
  Net Realized Gain..........................       --          --          --       (0.12)      (0.53)      (3.01)
  In Excess of Net Realized Gain.............       --          --          --       (0.13)         --          --
                                               ---------   ---------   ---------   ---------   ---------   ---------
Total Distributions..........................       --       (0.04)         --       (0.39)      (0.62)      (3.35)
                                               ---------   ---------   ---------   ---------   ---------   ---------
NET ASSET VALUE, END OF PERIOD...............  $  9.67     $ 13.63     $ 13.11     $ 26.20     $ 21.54     $ 19.48
                                               ---------   ---------   ---------   ---------   ---------   ---------
                                               ---------   ---------   ---------   ---------   ---------   ---------
TOTAL RETURN.................................    (3.30)%     41.50%      (3.82)%    105.71%     (15.81)%      6.87%
                                               ---------   ---------   ---------   ---------   ---------   ---------
                                               ---------   ---------   ---------   ---------   ---------   ---------
RATIOS AND SUPPLEMENTAL DATA:
Net Assets, End of Period (Thousands)........  $10,719     $41,017     $41,978     $287,136    $276,906    $314,884
Ratio of Expenses to Average Net Assets
 (1)(2)......................................     1.00%**     1.00%       1.00%**     1.00%       1.00%       1.00%
Ratio of Net Investment Income to Average Net
 Assets (1)(2)...............................     1.13%**     1.53%       0.61%**     0.83%       0.52%       0.97%
Portfolio Turnover Rate......................        2%         33%         10%         18%         47%         42%
</TABLE>
 
- ------------------------------
 
<TABLE>
<S> <C>                                        <C>         <C>         <C>         <C>         <C>         <C>
(1) Effect of voluntary expense limitation during the period:
    Per share benefit to net
       investment income.....................  $  0.02     $  0.06     $  0.02     $  0.05     $  0.04     $  0.03
    Ratios before expense limitation:
    Expenses to Average Net Assets...........     2.52%**     1.63%       2.02%**     1.38%       1.20%       1.18%
    Net Investment Income/(Loss)
       to Average Net Assets.................    (0.39)%**    0.90%      (0.41)%**    0.45%       0.32%       0.79%
</TABLE>
 
(2) Under the terms of an Investment Advisory Agreement, the Adviser is entitled
    to  receive a management  fee calculated at  an annual rate  of 0.80% of the
    average daily net  assets of  the Asian  Equity Portfolio.  The Adviser  has
    agreed  to waive  a portion  of this  fee and/or  reimburse expenses  of the
    Portfolio to the extent that the  total operating expenses of the  Portfolio
    exceed 1.00% of the average daily net assets of the Class A shares and 1.25%
    of  the average daily net assets of the Class B shares. In the fiscal period
    ended October 31,  1991, the  year ended October  31, 1992,  the two  months
    ended  December 31, 1992,  and the years  ended December 31,  1993, 1994 and
    1995, the Adviser waived management fees and/or reimbursed expenses totaling
    $44,000, $167,000, $70,000, $477,000,  $535,000 and $522,000,  respectively,
    for the Asian Equity Portfolio.
 
 * Commencement of Operations.
 
** Annualized.
 
 + Amount is less than $0.01 per share.
 
                                       10
<PAGE>
                           EUROPEAN EQUITY PORTFOLIO
 
<TABLE>
<CAPTION>
                                                 APRIL 2,
                                                 1993* TO       YEAR ENDED      YEAR ENDED
                                               DECEMBER 31,    DECEMBER 31,    DECEMBER 31,
                                                   1993            1994            1995
                                               -------------   -------------   -------------
<S>                                            <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........  $   10.00       $   12.91       $   13.94
                                               -------------   -------------   -------------
                                               -------------   -------------   -------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)(2)...............       0.08            0.08            0.14
  Net Realized and Unrealized Gain on
   Investments...............................       2.83            1.29            1.37
                                               -------------   -------------   -------------
  Total from Investment Operations...........       2.91            1.37            1.51
                                               -------------   -------------   -------------
DISTRIBUTIONS
  Net Investment Income......................         --           (0.09)          (0.15)
  Net Realized Gain..........................         --           (0.25)          (1.38)
                                               -------------   -------------   -------------
Total Distributions..........................         --           (0.34)          (1.53)
                                               -------------   -------------   -------------
NET ASSET VALUE, END OF PERIOD...............  $   12.91       $   13.94       $   13.92
                                               -------------   -------------   -------------
                                               -------------   -------------   -------------
TOTAL RETURN.................................      29.10%          10.88%          11.85%
                                               -------------   -------------   -------------
                                               -------------   -------------   -------------
RATIOS AND SUPPLEMENTAL DATA:
Net Assets, End of Period (Thousands)........  $  12,681       $  27,634       $  69,583
Ratio of Expenses to Average Net Assets
 (1)(2)......................................       1.00%**         1.00%           1.00%
Ratio of Net Investment Income to Average Net
 Assets (1)(2)...............................       1.23%**         0.87%           1.37%
Portfolio Turnover Rate......................         15%             79%             13%
</TABLE>
 
- ------------------------------
 
<TABLE>
<S> <C>                                        <C>             <C>             <C>
(1) Effect of voluntary expense limitation during the
     period:
    Per share benefit to net investment
     income..................................  $    0.09       $    0.06       $    0.03
    Ratios before expense limitation:
    Expenses to Average Net Assets...........       2.43%**         1.62%           1.25%
    Net Investment Income/(Loss) to Average
     Net Assets..............................      (0.21)%**        0.25%           1.12%
</TABLE>
 
(2) Under the terms of an Investment Advisory Agreement, the Adviser is entitled
    to  receive a management  fee calculated at  an annual rate  of 0.80% of the
    average daily net assets of the  European Equity Portfolio. The Adviser  has
    agreed  to waive  a portion  of this  fee and/or  reimburse expenses  of the
    Portfolio to the extent that the  total operating expenses of the  Portfolio
    exceed 1.00% of the average daily net assets of the Class A shares and 1.25%
    of  the average daily net assets of the Class B shares. In the fiscal period
    ended December 31, 1993, 1994 and  1995, the Adviser waived management  fees
    and/or   reimbursed  expenses  totaling   $88,000,  $112,000  and  $130,000,
    respectively, for the European Equity Portfolio.
 
 * Commencement of Operations.
 
** Annualized.
 
                                       11
<PAGE>
                           JAPANESE EQUITY PORTFOLIO
 
<TABLE>
<CAPTION>
                                                PERIOD FROM
                                                 APRIL 25,
                                                 1994* TO       YEAR ENDED
                                               DECEMBER 31,    DECEMBER 31,
                                                   1994            1995
                                               -------------   -------------
<S>                                            <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........  $   10.00       $    9.83
                                               -------------   -------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (Loss) (1)...........      (0.01)           0.04
  Net Realized and Unrealized Loss on
   Investments+..............................      (0.16)          (0.40)
                                               -------------   -------------
  Total from Investment Operations...........      (0.17)          (0.36)
                                               -------------   -------------
DISTRIBUTIONS
  In Excess of Net Investment Income.........         --           (0.20)
                                               -------------   -------------
NET ASSET VALUE, END OF PERIOD...............  $    9.83       $    9.27
                                               -------------   -------------
                                               -------------   -------------
TOTAL RETURN.................................      (1.70)%         (3.64)%
                                               -------------   -------------
                                               -------------   -------------
RATIOS AND SUPPLEMENTAL DATA:
Net Assets, End of Period (Thousands)........  $  50,332       $ 119,278
Ratio of Expenses to Average Net Assets
 (1)(2)......................................       1.00%**         1.00%
Ratio of Net Investment Income (Loss) to
 Average Net Assets (1)(2)...................      (0.10)%**        0.15%
Portfolio Turnover Rate......................          1%             52%
</TABLE>
 
- ------------------------
 
<TABLE>
<S> <C>                                        <C>             <C>
(1) Effect of voluntary expense limitation during the period:
    Per share benefit to net investment
     income..................................  $    0.02       $    0.06
    Ratios before expense limitation:
    Expenses to Average Net Assets...........       1.27%**         1.20%
    Net Investment Loss to Average Net
     Assets..................................      (0.37)%**       (0.05)%
</TABLE>
 
(2) Under the terms of an Investment Advisory Agreement, the Adviser is entitled
    to receive a management  fee calculated at  an annual rate  of 0.80% of  the
    average  daily net assets of the  Japanese Equity Portfolio. The Adviser has
    agreed to  waive a  portion of  this fee  and/or reimburse  expenses of  the
    Portfolio  to the extent that the  total operating expenses of the Portfolio
    exceed 1.00% of the average daily net assets of the Class A shares and 1.25%
    of the average daily net assets of the Class B shares. In the fiscal  period
    ended  December 31, 1994 and 1995, the Adviser waived management fees and/or
    reimbursed expenses  totaling $80,000  and $118,000,  respectively, for  the
    Japanese Equity Portfolio.
 
 * Commencement of Operations.
 
** Annualized.
 
 + The amount shown for the year ended December 31, 1995 for a share outstanding
   throughout  the year does not accord  with aggregate net gains on investments
   for the year because of the timing of sales and repurchases of the  Portfolio
   shares  in relation  to fluctuating  market value  of the  investments in the
   Portfolio.
 
                                       12
<PAGE>
                            LATIN AMERICAN PORTFOLIO
 
<TABLE>
<CAPTION>
                                               PERIOD FROM JANUARY
                                                  18, 1995* TO
                                                DECEMBER 31, 1995
                                               -------------------
<S>                                            <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........  $         10.00
                                                       -------
                                                       -------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)..................             0.05
  Net Realized and Unrealized Loss on
   Investments...............................            (0.92)
                                                       -------
  Total from Investment Operations...........            (0.87)
                                                       -------
DISTRIBUTIONS
  Net Investment Income......................            (0.04)
  Return of Capital..........................            (0.03)
                                                       -------
Total Distributions..........................            (0.07)
                                                       -------
NET ASSET VALUE, END OF PERIOD...............  $          9.06
                                                       -------
                                                       -------
TOTAL RETURN.................................            (8.68)%
                                                       -------
                                                       -------
RATIOS AND SUPPLEMENTAL DATA:
Net Assets, End of Period (Thousands)........  $        15,376
Ratio of Expenses to Average Net Assets
 (1)(2)......................................             1.70%**
Ratio of Net Investment Income to Average Net
 Assets (1)(2)...............................             0.62%**
Portfolio Turnover Rate......................              137%
</TABLE>
 
- ------------------------
 
<TABLE>
<S> <C>                                        <C>
(1) Effect of voluntary expense limitation during the period:
    Per share benefit to net investment
     income..................................  $          0.09
    Ratios before expense limitation:
    Expenses to Average Net Assets...........             3.13%**
    Net Investment Loss to Average Net
     Assets..................................            (0.48)%**
</TABLE>
 
(2) Under the terms of an Investment Advisory Agreement, the Adviser is entitled
    to receive a management  fee calculated at  an annual rate  of 1.10% of  the
    average  daily net assets  of the Latin American  Portfolio. The Adviser has
    agreed to  waive a  portion of  this fee  and/or reimburse  expenses of  the
    Portfolio  to the extent that the  total operating expenses of the Portfolio
    exceed 1.70% of the average daily net assets of the Class A shares and 1.95%
    of the average daily net assets of the Class B shares. In the fiscal  period
    ended   December  31,  1995,  the  Adviser  waived  management  fees  and/or
    reimbursed expenses totalling $146,000 for the Portfolio.
 
 * Commencement of Operations.
 
** Annualized.
 
                                       13
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The   Fund  consists  of  twenty-eight  portfolios,  offering  institutional
investors and high net  worth individual investors a  broad range of  investment
choices coupled with the advantages of a no-load mutual fund with Morgan Stanley
and  its affiliates providing customized  services as Adviser, Administrator and
Distributor.  Each  portfolio  offers  Class  A  shares  and,  except  for   the
International  Small Cap,  Money Market  and Municipal  Money Market Portfolios,
also offers Class B shares. Each portfolio has its own investment objective  and
policies  designed to meet its specific  goals. The investment objective of each
Portfolio described in this Prospectus is as follows:
 
    -The  GLOBAL  EQUITY  PORTFOLIO  seeks  long-term  capital  appreciation  by
     investing  primarily in equity securities  of issuers throughout the world,
     including U.S. issuers.
 
    -The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation  by
     investing primarily in equity securities of non-U.S. issuers.
 
    -The  INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
     by investing primarily in equity securities of non-U.S. issuers with equity
     market capitalizations of less than $1 billion.
 
    -The  ASIAN  EQUITY  PORTFOLIO  seeks  long-term  capital  appreciation   by
     investing primarily in equity securities of Asian issuers.
 
    -The  EUROPEAN  EQUITY  PORTFOLIO seeks  long-term  capital  appreciation by
     investing primarily in equity securities of European issuers.
 
    -The JAPANESE  EQUITY  PORTFOLIO seeks  long  term capital  appreciation  by
     investing primarily in equity securities of Japanese issuers.
 
    -The  LATIN  AMERICAN  PORTFOLIO  seeks  long-term  capital  appreciation by
     investing primarily in equity securities of Latin American issuers and debt
     securities  issued  or   guaranteed  by  Latin   American  governments   or
     governmental entities.
 
    The  other portfolios of the Fund  are described in other Prospectuses which
may be obtained from the Fund at the address and phone number noted on the cover
page of this  Prospectus. The objectives  of these other  portfolios are  listed
below:
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    -The   ACTIVE   COUNTRY   ALLOCATION  PORTFOLIO   seeks   long-term  capital
     appreciation by investing in accordance with country weightings  determined
     by  the  Adviser in  equity securities  of non-U.S.  issuers which,  in the
     aggregate, replicate broad country indices.
 
    -The CHINA GROWTH PORTFOLIO seeks to provide long-term capital  appreciation
     by  investing primarily  in equity  securities of  issuers in  The People's
     Republic of China, Hong Kong and Taiwan.
 
    -The EMERGING  MARKETS PORTFOLIO  seeks  long-term capital  appreciation  by
     investing primarily in equity securities of emerging country issuers.
 
    -The  INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers in  accordance
     with EAFE country (as defined in "Investment Objective and Policies" below)
     weightings determined by the Adviser.
 
                                       14
<PAGE>
    -The  GOLD  PORTFOLIO  seeks  long-term  capital  appreciation  by investing
     primarily in equity securities of  foreign and domestic issuers engaged  in
     gold-related activities.
 
    U.S. EQUITY:
 
    -The  AGGRESSIVE EQUITY  PORTFOLIO seeks  capital appreciation  by investing
     primarily in corporate equity and equity-linked securities.
 
    -The EMERGING  GROWTH  PORTFOLIO  seeks long-term  capital  appreciation  by
     investing  primarily  in  growth-oriented equity  securities  of  small- to
     medium-sized corporations.
 
    -The  EQUITY  GROWTH  PORTFOLIO  seeks  long-term  capital  appreciation  by
     investing  in  growth-oriented  equity securities  of  large capitalization
     companies.
 
    -The MICROCAP PORTFOLIO  seeks long-term capital  appreciation by  investing
     primarily in growth-oriented equity securities of small corporations.
 
    -The  SMALL CAP VALUE EQUITY PORTFOLIO  seeks high long-term total return by
     investing in  undervalued  equity  securities  of  small-  to  medium-sized
     companies.
 
    -The  U.S.  REAL ESTATE  PORTFOLIO seeks  to  provide above  average current
     income and long-term capital appreciation by investing primarily in  equity
     securities  of companies in  the U.S. real  estate industry, including real
     estate investment trusts.
 
    -The VALUE EQUITY PORTFOLIO seeks high  total return by investing in  equity
     securities  which the  Adviser believes to  be undervalued  relative to the
     stock market in general at the time of purchase.
 
    EQUITY AND FIXED INCOME:
 
    -The BALANCED PORTFOLIO seeks high total return while preserving capital  by
     investing  in  a combination  of  undervalued equity  securities  and fixed
     income securities.
 
    FIXED INCOME:
 
    -The EMERGING MARKETS DEBT  PORTFOLIO seeks high  total return by  investing
     primarily   in  debt  securities   of  government,  government-related  and
     corporate issuers located in emerging countries.
 
    -The FIXED INCOME PORTFOLIO seeks to produce a high total return  consistent
     with the preservation of capital by investing in a diversified portfolio of
     fixed income securities.
 
    -The  GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
     of return while preserving capital by investing in fixed income  securities
     of issuers throughout the world, including U.S. issuers.
 
    -The  HIGH YIELD PORTFOLIO seeks to maximize  total return by investing in a
     diversified portfolio of high  yield fixed income  securities that offer  a
     yield  above  that  generally available  on  debt securities  in  the three
     highest rating categories of the recognized rating services.
 
    -The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks  to produce as high a  level
     of  current income  as is  consistent with  the preservation  of capital by
     investing primarily  in  a  variety  of  investment  grade  mortgage-backed
     securities.
 
    -The  MUNICIPAL  BOND PORTFOLIO  seeks to  produce a  high level  of current
     income  consistent  with  preservation  of  principal  through   investment
     primarily  in municipal obligations,  the interest on  which is exempt from
     federal income tax.
 
                                       15
<PAGE>
    MONEY MARKET:
 
    -The MONEY MARKET PORTFOLIO  seeks to maximize  current income and  preserve
     capital  while maintaining  high levels  of liquidity  through investing in
     high quality money market instruments with remaining maturities of one year
     or less.
 
    -The MUNICIPAL MONEY MARKET PORTFOLIO  seeks to maximize current  tax-exempt
     income  and  preserve capital  while maintaining  high levels  of liquidity
     through investing in high quality  money market instruments with  remaining
     maturities of one year or less which are exempt from federal income tax.
 
INVESTMENT MANAGEMENT
 
    Morgan  Stanley Asset Management  Inc., a wholly  owned subsidiary of Morgan
Stanley Group  Inc.,  which,  together  with  its  affiliated  asset  management
companies,  at December 31, 1995 had approximately $57.4 billion in assets under
management as  an  investment  manager  or  as  a  fiduciary  adviser,  acts  as
investment  adviser to the Fund  and each of its  portfolios. See "Management of
the Fund -- Investment Adviser" and "Management of the Fund -- Administrator."
 
HOW TO INVEST
 
    Class A shares of  each Portfolio are offered  directly to investors at  net
asset  value with no sales commission or  12b-1 charges. Class B shares, offered
only by the Multiclass Portfolios, are offered at net asset value with no  sales
commission,  but with a  12b-1 fee, which  is accrued daily  and paid quarterly,
equal to 0.25% of the Class B shares' average daily net assets on an  annualized
basis.  Share purchases may be made by  sending investments directly to the Fund
or through  the Distributor.  Shares  in a  Portfolio  account opened  prior  to
January  2,  1996 were  designated  Class A  shares on  January  2, 1996.  For a
Multiclass Portfolio  account  opened  on  or after  January  2,  1996  (a  "New
Multiclass  Account"), the  minimum initial investment  is $500,000  for Class A
shares of each  Multiclass Portfolio  and $100,000 for  Class B  shares of  each
Multiclass  Portfolio. The International Equity Portfolio is currently closed to
new investors  with  the exception  of  certain Morgan  Stanley  customers.  The
minimum  initial investment  for Class A  shares of the  International Small Cap
Portfolio is $500,000. Certain exceptions to the foregoing minimums apply to (1)
shares in a Multiclass Portfolio account opened prior to January 2, 1996  (each,
a  "Pre-1996 Multiclass Account") with  a value of $100,000  or more on March 1,
1996 (a  "Grandfathered  Class  A  Account"); (2)  Portfolio  accounts  held  by
officers  of the Adviser and  its affiliates; and (3)  certain advisory or asset
allocation accounts, such as Total Funds Management accounts, managed by  Morgan
Stanley  or  its affiliates,  including  the Adviser  ("Managed  Accounts"). The
Adviser reserves the  right in its  sole discretion to  determine which of  such
advisory or asset allocation accounts shall be Managed Accounts. For information
regarding   Managed  Accounts,  please  contact   your  Morgan  Stanley  account
representative or the Fund at the telephone number provided on the cover of this
Prospectus. Shares in a  Pre-1996 Multiclass Account with  a value of less  than
$100,000 on March 1, 1996 (a "Grandfathered Class B Account") converted to Class
B  shares on March 1,  1996. The minimum investment levels  may be waived at the
discretion of the  Adviser for  (i) certain  employees and  customers of  Morgan
Stanley  or  its affiliates  and  certain trust  departments,  brokers, dealers,
agents, financial  planners, financial  services firms,  or investment  advisers
that  have entered into an agreement with  Morgan Stanley or its affiliates; and
(ii) retirement and  deferred compensation plans  and trusts used  to fund  such
plans, including, but not limited to, those defined in Section 401(a), 403(b) or
457  of the Internal Revenue  Code of 1986, as  amended, and "rabbi trusts." See
"Purchase of Shares  -- Minimum  Investment and Account  Sizes; Conversion  from
Class A to Class B Shares."
 
                                       16
<PAGE>
    The  minimum  subsequent investment  for  each Portfolio  account  is $1,000
(except for automatic reinvestment of dividends and capital gains  distributions
for  which there is no minimum). Such  subsequent investments will be applied to
purchase additional  shares  in  the same  class  held  by a  shareholder  in  a
Portfolio account. See "Purchase of Shares -- Additional Investments."
 
HOW TO REDEEM
 
    Class  A  shares of  each Portfolio  or  Class B  shares of  each Multiclass
Portfolio may be redeemed at any time, without cost, at the net asset value  per
share  of shares of  the applicable class  next determined after  receipt of the
redemption request. The redemption price may  be more or less than the  purchase
price.  Certain  redemptions  may  cause  involuntary  redemption  or  automatic
conversion. Class  A or  Class B  shares  held in  New Multiclass  Accounts  are
subject  to involuntary redemption  if shareholder redemption(s)  of such shares
reduces the value of such account to less than $100,000 for a continuous  60-day
period. Involuntary redemption does not apply to Managed Accounts, Grandfathered
Class  A Accounts and Grandfathered Class B Accounts, regardless of the value of
such accounts. Class A shares in a New Multiclass Account will convert to  Class
B  shares if shareholder redemption(s) of such  shares reduces the value of such
account to less than $500,000 for a continuous 60-day period. Class B shares  in
a New Multiclass Account will convert to Class A shares if shareholder purchases
of  additional Class B shares or market activity  cause the value of the Class B
shares in the  New Multiclass  Account to  increase to  $500,000 or  more. If  a
shareholder  reduces its total investment in Class A shares of the International
Small Cap Portfolio  to less  than $500,000, the  investment may  be subject  to
redemption.  See "Purchase  of Shares --  Minimum Account  Sizes and Involuntary
Redemption of Shares" and "Redemption of Shares."
 
RISK FACTORS
 
    The investment policies of each of  the Portfolios entail certain risks  and
considerations  of which an investor should be aware. Each Portfolio will invest
in securities  of  foreign issuers,  which  are  subject to  certain  risks  not
typically  associated  with domestic  securities.  The Latin  American Portfolio
invests in securities of  issuers located in  developing countries and  emerging
markets. These securities may impose greater liquidity risks and other risks not
typically  associated  with investing  in  more established  markets.  The Latin
American Portfolio may invest up to 20% of its total assets in lower rated  debt
securities  ("junk  bonds"),  including  sovereign  debt,  which  securities are
considered speculative with  regard to  the payment  of interest  and return  of
principal.  See "Investment Objectives and  Policies" and "Additional Investment
Information." In addition, each Portfolio  may invest in repurchase  agreements,
lend  its portfolio  securities, purchase securities  on a  when-issued basis or
delayed  delivery  basis  and  invest  in  forward  foreign  currency   exchange
contracts,  and  the Latin  American Portfolio  may  invest in  foreign currency
exchange options to hedge currency  risk associated with investment in  non-U.S.
dollar  denominated  securities.  Each  Portfolio may  invest  in  short-term or
medium-term debt  securities or  hold  cash or  cash equivalents  for  temporary
defensive  purposes.  The  International  Small  Cap  Portfolio  may  invest  in
securities  that   are  neither   listed  on   a  stock   exchange  nor   traded
over-the-counter,  including  private placement  securities. The  Global Equity,
Japanese Equity,  Latin American  and Asian  Equity Portfolios  may also  invest
indirectly  in securities  through sponsored or  unsponsored American Depositary
Receipts. Each of these investment strategies involves specific risks which  are
described  under "Investment Objectives and Policies" and "Additional Investment
Information" herein  and  under  "Investment Objectives  and  Policies"  in  the
Statement of Additional Information.
 
                                       17
<PAGE>
                       INVESTMENT OBJECTIVES AND POLICIES
 
    The investment objective of each Portfolio is described below, together with
the  policies the Fund employs in its  efforts to achieve these objectives. Each
Portfolio's investment  objective  is a  fundamental  policy which  may  not  be
changed without the approval of a majority of the Portfolio's outstanding voting
securities.  There is no assurance that the Fund will attain its objectives. The
investment policies  described below  are not  fundamental policies  and may  be
changed without shareholder approval.
 
THE GLOBAL EQUITY PORTFOLIO
 
    The   Global  Equity  Portfolio  seeks  long-term  capital  appreciation  by
investing primarily  in  equity  securities of  issuers  throughout  the  world,
including U.S. issuers. With respect to the Portfolio, equity securities include
common  and preferred stocks, convertible securities, and rights and warrants to
purchase common stocks. The Adviser expects that, under normal circumstances, at
least 20% of the Portfolio's total assets will be invested in the common  stocks
of  U.S. issuers.  The remainder  of the Portfolio  will be  invested in issuers
located throughout the world,  including those located  in emerging markets.  At
least  65%  of the  total assets  of the  Portfolio will  be invested  in equity
securities under normal circumstances. Securities in emerging markets may not be
as liquid as  those in developed  markets and pose  greater risks. Although  the
Portfolio  intends to invest primarily in  securities listed on stock exchanges,
it will  also  invest in  securities  traded in  over-the-counter  markets.  The
Adviser's orientation to individual stock selection and value driven approach in
selecting  investments for the Portfolio are the same as those described for the
International Equity  Portfolio discussed  below. The  Portfolio may  invest  in
American, Global or other types of Depositary Receipts.
 
    Although  the  Portfolio will  not invest  for short-term  trading purposes,
investment securities may be sold from time to time without regard to the length
of time they have been held. It is anticipated that the annual turnover rate  of
the Portfolio will not exceed 100% under normal circumstances.
 
    Any remaining assets of the Portfolio not invested as described above may be
invested  in  certain  securities or  obligations  as set  forth  in "Additional
Investment Information" below.
 
THE INTERNATIONAL EQUITY PORTFOLIO
 
    The investment objective of the International Equity Portfolio is to provide
long-term  capital  appreciation.  The  production  of  any  current  income  is
incidental  to this objective.  The Portfolio seeks to  achieve its objective by
investing primarily in equity  securities of non-U.S.  issuers. With respect  to
the   Portfolio,  equity   securities  include  common   and  preferred  stocks,
convertible securities, and rights  and warrants to  purchase common stocks.  At
least  65% of the total assets of the  Portfolio will be invested in such equity
securities under normal circumstances.
 
    The Adviser's  approach  in  selecting  investments  for  the  Portfolio  is
oriented to individual stock selection, and is value driven. In selecting stocks
for  the  Portfolio,  the Adviser  initially  identifies those  stocks  which it
believes to  be undervalued  in  relation to  the  issuer's assets,  cash  flow,
earnings  and revenues, and  then evaluates the  future value of  such stocks by
running the  results of  an in-depth  study  of the  issuer through  a  dividend
discount  model.  The Adviser  utilizes  the research  of  a number  of sources,
including  its  affiliate  in   Geneva,  Switzerland,  Morgan  Stanley   Capital
International,  in identifying  attractive securities,  and applies  a number of
 
                                       18
<PAGE>
proprietary screening criteria to  identify those securities  it believes to  be
undervalued.   Portfolio  holdings  are  regularly  reviewed  and  subjected  to
fundamental analysis  to  determine whether  they  continue to  conform  to  the
Adviser's  value  criteria. Securities  which no  longer  conform to  such value
criteria are sold.
 
    While  the   Portfolio   is  not   subject   to  any   specific   geographic
diversification  requirements,  it  currently intends  to  diversify investments
among countries to reduce currency risk.  Investments will be made primarily  in
equity securities of companies domiciled in developed countries, but may also be
made  in equity  securities of  companies domiciled  in developing  countries as
well. Although the Portfolio  intends to invest  primarily in equity  securities
listed  on stock exchanges, it  will also invest in  equity securities traded in
over-the-counter markets. Securities  of companies in  developing countries  may
pose liquidity risks. The Portfolio will not, under normal circumstances, invest
in   equity  securities   of  U.S.  issuers.   For  a   description  of  special
considerations and certain risks associated with investments in foreign issuers,
see "Additional Investment  Information." The Portfolio  may temporarily  reduce
its  equity  holdings  for  defensive purposes  in  response  to  adverse market
conditions and  invest  in domestic,  Eurodollar  and foreign  short-term  money
market instruments. See "Investment Objectives and Policies" in the Statement of
Additional Information.
 
    Although  the  Portfolio will  not invest  for short-term  trading purposes,
investment securities may be sold from time to time without regard to the length
of time they have been held. It is anticipated that the annual turnover rate  of
the Portfolio will not exceed 100% under normal circumstances.
 
    Any remaining assets of the Portfolio not invested as described above may be
invested  in  certain  securities or  obligations  as set  forth  in "Additional
Investment Information" below.
 
THE INTERNATIONAL SMALL CAP PORTFOLIO
 
    The investment  objective of  the International  Small Cap  Portfolio is  to
provide  long-term capital appreciation. The production of any current income is
incidental to this objective.  The Portfolio seeks to  achieve its objective  by
investing  primarily in equity securities of non-U.S. issuers with equity market
capitalizations of less than $1 billion.  With respect to the Portfolio,  equity
securities  include  common and  preferred  stocks, convertible  securities, and
rights and warrants to purchase common stocks. At least 65% of the total  assets
of  the  Portfolio  will be  invested  in  such equity  securities  under normal
circumstances. The Portfolio will invest a minimum of 80% of its total assets in
companies with market  capitalizations of  less than $1  billion. The  Adviser's
orientation to individual stock selection and value driven approach in selecting
investments  for  the  Portfolio  are  the  same  as  those  described  for  the
International Equity Portfolio discussed above.
 
    While  the   Portfolio   is  not   subject   to  any   specific   geographic
diversification  requirements,  it  currently intends  to  diversify investments
among countries to reduce currency risk.  Investments will be made primarily  in
equity  securities of  companies domiciled  in developed  countries, but limited
investments may  also  be made  in  the  securities of  companies  domiciled  in
developing  countries as  well, and  will not  normally exceed  5% of  the total
assets of the Portfolio. Although the  Portfolio intends to invest primarily  in
equity  securities  listed on  stock  exchanges, it  may  also invest  in equity
securities traded in over-the-counter  markets. Small capitalization  securities
involve  greater issuer  risk and  the markets for  such securities  may be more
volatile and less liquid.  Securities of companies  in developing countries  may
pose liquidity risks. The Portfolio will not, under normal circumstances, invest
in   equity  securities   of  U.S.  issuers.   For  a   description  of  special
considerations and certain risks associated with investments in foreign issuers,
see "Additional Investment Information." The Portfolio may
 
                                       19
<PAGE>
temporarily reduce its  equity holdings  for defensive purposes  in response  to
adverse  market  conditions  and  invest  in  domestic,  Eurodollar  and foreign
short-term money market instruments. See "Investment Objectives and Policies" in
the Statement of Additional Information.
 
    Although the  Portfolio will  not invest  for short-term  trading  purposes,
investment securities may be sold from time to time without regard to the length
of  time they have been held. It is anticipated that the annual turnover rate of
the Portfolio will not exceed 100% under normal circumstances.
 
    Any remaining assets of the Portfolio not invested as described above may be
invested in  certain  securities or  obligations  as set  forth  in  "Additional
Investment Information" below.
 
THE ASIAN EQUITY PORTFOLIO
 
    The  investment  objective  of  the Asian  Equity  Portfolio  is  to provide
long-term  capital  appreciation.  The  production  of  any  current  income  is
incidental  to this objective.  The Portfolio seeks to  achieve its objective by
investing primarily in equity  securities which are  traded on recognized  stock
exchanges  of the countries in Asia described  below and in equity securities of
companies organized  under  the laws  of  an  Asian country  whose  business  is
conducted principally in Asia. The Portfolio does not intend to invest in equity
securities  which are  principally traded  in markets  in Japan  or in companies
organized under the  laws of Japan.  The Portfolio may  also invest in  American
Depositary  Receipts of Asian issuers that are  traded on stock exchanges in the
U.S.
 
    The Asian countries to  be represented in the  Portfolio, which include  the
following countries, have the more established markets in the region: Hong Kong,
Singapore,  Malaysia, Thailand, the Philippines and Indonesia. The Portfolio may
also invest in common  stocks traded on markets  in Taiwan, South Korea,  India,
Pakistan,  Sri  Lanka and  other  developing markets  that  are open  to foreign
investment. There is no requirement that the Fund, at any given time, invest  in
any  or all of the  countries listed above or in  any other Asian countries. The
Fund has  no set  policy  for allocating  investments  among the  various  Asian
countries.  Allocation of investments will depend on the relative attractiveness
of the stocks of issuers in the respective countries. Government regulation  and
restrictions in many of the countries of interest may limit the amount, mode and
extent of investment in companies of such countries.
 
    At least 65% of the total assets of the Portfolio will be invested in common
stocks  of Asian countries under normal  circumstances. The remaining portion of
the Fund will be kept in any combination of debt instruments, bills and bonds of
governmental entities in Asia and the  U.S., in notes, debentures, and bonds  of
companies  in Asia and in  money market instruments of  the U.S. With respect to
the  Portfolio,  equity   securities  include  common   and  preferred   stocks,
convertible securities, and rights and warrants to purchase common stocks.
 
    The  Adviser's orientation  to individual  stock selection  and value driven
approach in  selecting  investments  for  the Portfolio  are  similar  to  those
described  for the International  Equity Portfolio discussed  above. The Adviser
will analyze assets, revenues and earnings of an issuer. In selecting industries
and particular  issuers,  the Adviser  will  evaluate  costs of  labor  and  raw
materials,  access to technology, export  of products and government regulation.
Although the Portfolio  seeks to invest  in larger companies,  it may invest  in
medium  and  small companies  that, in  the Adviser's  view, have  potential for
growth.
 
    The Portfolio's investments  will include securities  of issuers located  in
developing  countries  and traded  in  emerging markets.  These  securities pose
greater  liquidity  risks   and  other  risks   than  securities  of   companies
 
                                       20
<PAGE>
located  in developed  countries and traded  in more established  markets. For a
description  of  special  considerations  and  certain  risks  associated   with
investment in foreign issuers, see "Additional Investment Information -- Foreign
Investment."  See also "Investment Objectives and  Policies" in the Statement of
Additional Information.
 
    Although the  Portfolio intends  to invest  primarily in  equity  securities
listed  on stock exchanges, it  will also invest in  equity securities traded in
over-the-counter markets.  Securities traded  in over-the-counter  markets  pose
liquidity  risks. The Portfolio  may also invest in  initial public offerings in
the form of oversubscriptions or private placements. Such investments  generally
entail short-term liquidity risks.
 
    Although  the  Portfolio will  not invest  for short-term  trading purposes,
investment securities may be sold from time to time without regard to the length
of time they have been held. It is anticipated that the annual turnover rate  of
the Portfolio will not exceed 100% under normal circumstances.
 
    Pending  investment or settlement, and for liquidity purposes, the Portfolio
may  invest  in  domestic,  Eurodollar  and  foreign  short-term  money   market
instruments.  The Portfolio  may also  purchase such  instruments to temporarily
reduce its equity holdings for defensive purposes in response to adverse  market
conditions.
 
    Because  of the lack of hedging facilities  in the currency markets of Asia,
no active  currency hedging  strategy is  anticipated currently.  Instead,  each
investment  will be considered on a total  currency adjusted basis with the U.S.
dollar as  a  base currency.  The  Portfolio  may engage  in  currency  exchange
contracts.  See "Statement of Additional Information -- Forward Foreign Currency
Exchange Contracts" in this Prospectus.
 
    Any remaining assets of the Portfolio not invested as described above may be
invested in  certain  securities or  obligations  as set  forth  in  "Additional
Investment Information" below.
 
THE EUROPEAN EQUITY PORTFOLIO
 
    The  investment objective  of the  European Equity  Portfolio is  to provide
long-term capital appreciation. The Portfolio seeks to achieve this objective by
investing primarily in  equity securities of  European issuers, including  those
located  in  Germany,  France,  Switzerland,  Belgium,  Italy,  Finland, Sweden,
Denmark, Norway and the United Kingdom.  Investments may also be made in  equity
securities  of issuers  located in the  smaller and emerging  markets of Europe.
With respect to the  Portfolio, equity securities  include common and  preferred
stocks,  convertible  securities, and  rights  and warrants  to  purchase common
stocks. At least 65% of  the total assets of the  Portfolio will be invested  in
equity  securities of European issuers under normal circumstances. The Adviser's
orientation to individual stock selection and value-driven approach in selecting
investments  for  the  Portfolio  are  the  same  as  those  described  for  the
International  Equity Portfolio discussed above.  Securities in emerging markets
may not be  as liquid  as those  in developed  markets and  pose greater  risks.
Although  the Portfolio intends to invest  primarily in equity securities listed
on stock  exchanges,  it  will  also  invest  in  equity  securities  traded  in
over-the-counter markets.
 
    While   the   Portfolio  is   not   subject  to   any   specific  geographic
diversification requirements,  it  currently intends  to  diversify  investments
among  countries to reduce  currency risk. Investments may  be made primarily in
equity securities of companies domiciled in developed countries, but may also be
made in  equity securities  of companies  domiciled in  developing countries  as
well.  Although the Portfolio  intends to invest  primarily in equity securities
listed on  stock  exchanges,  it  will  also  invest  in  securities  traded  in
over-the-counter  markets. Securities  of companies in  developing countries may
pose   liquidity    risks.    The    Portfolio   will    not,    under    normal
 
                                       21
<PAGE>
circumstances, invest in equity securities of U.S. issuers. For a description of
special  considerations and certain risks associated with investments in foreign
issuers, see "Additional Investment Information." The Portfolio may  temporarily
reduce  its equity holdings for defensive purposes in response to adverse market
conditions and  invest  in domestic,  Eurodollar  and foreign  short-term  money
market instruments. See "Investment Objectives and Policies" in the Statement of
Additional Information.
 
    Although  the  Portfolio will  not invest  for short-term  trading purposes,
investment securities may be sold from time to time without regard to the length
of time they have been held. It is anticipated that the annual turnover rate  of
the Portfolio will not exceed 100% under normal circumstances.
 
    Any remaining assets of the Portfolio not invested as described above may be
invested  in  certain  securities or  obligations  as set  forth  in "Additional
Investment Information" below.
 
THE JAPANESE EQUITY PORTFOLIO
 
    The investment  objective of  the Japanese  Equity Portfolio  is to  provide
long-term capital appreciation. The Portfolio seeks to achieve this objective by
investing  primarily in equity  securities of Japanese  issuers. With respect to
the  Portfolio,  equity   securities  include  common   and  preferred   stocks,
convertible securities, and rights and warrants to purchase common stocks.
 
    Under normal conditions, the Portfolio will invest at least 80% of its total
assets  in securities issued  by entities that  are organized under  the laws of
Japan, affiliates  of Japanese  companies (wherever  organized or  traded),  and
issuers  not organized under the laws of Japan but deriving 50% or more of their
revenues from Japan. These securities may include debt securities (issued by the
Japanese government or by Japanese companies) when the Adviser believes that the
potential for capital appreciation from investment in debt securities equals  or
exceeds   that  available  from  investment  in  equity  securities.  In  making
investment decisions, the Adviser will  consider, among other factors, the  size
of  the company, its financial condition,  its marketing and technical strengths
and its  competitiveness in  its  industry. All  debt  securities in  which  the
Portfolio  may  invest will  be rated  no lower  than BBB  by Standard  & Poor's
Ratings Group ("S&P"), Baa by Moody's Investors Service, Inc. ("Moody's") or BBB
by Mikuni  Inc.  ("Mikuni")  (a  Japanese rating  agency)  or,  if  unrated,  of
comparable  quality as determined  by the Adviser. Securities  rated BBB by S&P,
Baa by Moody's or BBB by Mikuni have speculative characteristics and changes  in
economic conditions or other circumstances are more likely to lead to a weakened
capacity  to make principal and interest  payments on such securities than would
be the case with  higher rated securities. The  convertible securities in  which
the  Portfolio may invest include bonds, notes, debentures, preferred stocks and
other securities convertible into common stocks and may be fixed-income or  zero
coupon  debt securities. Prior  to their conversion,  convertible securities may
have characteristics similar to nonconvertible debt securities.
 
    The Portfolio  currently  intends  to  focus  its  investments  in  Japanese
companies  that have  an active  market for  their shares  and that  the Adviser
believes show  a  potential  for  better  than  average  growth.  The  Portfolio
anticipates  that  most  equity securities  of  Japanese companies  in  which it
invests, either directly or indirectly by means of American Depositary  Receipts
or  convertible debentures, will be listed on securities exchanges in Japan. The
Portfolio may also invest  in equity securities of  Japanese companies that  are
traded in an over-the-counter market.
 
                                       22
<PAGE>
    The  Portfolio may  also invest  up to 20%  of its  total assets  in cash or
short-term government  or  other  short-term  prime  obligations  or  repurchase
agreements  so  that  funds  may  be  readily  available  for  general corporate
purposes,  including  the  payment  of  dividends,  redemptions  and   operating
expenses,  for investment in securities through exercise of rights or otherwise.
For temporary defensive purposes,  the Portfolio may invest  some or all of  its
assets in cash or such short-term obligations.
 
    Although  the  Portfolio will  not invest  for short-term  trading purposes,
investment securities may be sold from time to time without regard to the length
of time  they  have been  held.  It is  anticipated  that the  annual  portfolio
turnover rate of the Portfolio will not exceed 100% under normal circumstances.
 
    Any remaining assets of the Portfolio not invested as described above may be
invested  in  certain  securities or  obligations  as set  forth  in "Additional
Investment Information" below.
 
    RISK FACTORS  RELATING  TO  JAPANESE EQUITY  PORTFOLIO.    Investors  should
consider the following factors inherent in investment in Japan.
 
    TRADE  ISSUES.  Because  of the concentration of  Japanese exports in highly
visible products such as automobiles, machine tools and semiconductors, and  the
large  trade surpluses ensuing therefrom,  Japan is in a  difficult phase in its
relation with  its trading  partners,  particularly the  U.S., where  the  trade
imbalance  is the  greatest. Retaliatory action  taken by  such trading partners
could affect  the  ability  of  Japanese companies  to  export  goods  to  these
countries,  which  could  negatively  impact  the  value  of  securities  in the
Portfolio.
 
    CURRENCY FACTORS.   Over  a long  period  of years,  the yen  has  generally
appreciated  in relation to the dollar. The  yen's appreciation would add to the
returns of dollars  invested through the  Portfolio in Japan.  A decline in  the
value  of the yen would have the  opposite effect, adversely affecting the value
of the Portfolio in dollar terms.
 
    THE JAPANESE STOCK  MARKET.  Like  other stock markets,  the Japanese  stock
market  can be volatile. A  decline in the market may  have an adverse effect on
the availability of credit and on the value of the substantial stock holdings of
Japanese companies in particular, Japanese banks, insurance companies and  other
financial  institutions. A decline  in the market may  contribute to weakness in
Japan's economy. The common stocks of many Japanese companies continue to  trade
at  high price-earnings ratios even after the recent market decline. Differences
in accounting methods  make it  difficult to  compare the  earnings of  Japanese
companies  with those  of companies in  other countries, especially  the U.S. In
general, however, reported net income in  Japan is understated relative to  U.S.
accounting  standards. In addition, Japanese  companies have tended historically
to have higher  growth rates than  U.S. companies, and  Japanese interest  rates
have generally been lower than in the U.S., both of which factors tend to result
in  lower discount rates and  higher price-earnings ratios in  Japan than in the
U.S.
 
THE LATIN AMERICAN PORTFOLIO
 
    The investment  objective  of  the Latin  American  Portfolio  is  long-term
capital appreciation. The Portfolio seeks to achieve this objective by investing
primarily  in equity securities (i)  of companies organized in  or for which the
principal securities trading market is in  Latin America, (ii) denominated in  a
Latin  American  currency issued  by companies  to  finance operations  in Latin
America, or (iii) of companies that alone or on a consolidated basis derive  50%
or  more of  their annual  revenues from  either goods  produced, sales  made or
services
 
                                       23
<PAGE>
performed in  Latin  America (collectively,  "Latin  American issuers")  and  by
investing, from time to time, in debt securities issued or guaranteed by a Latin
American  government or governmental entity ("Sovereign  Debt"). Income is not a
consideration in selecting investments or an investment objective.
 
    Under normal conditions, substantially  all, but not less  than 80%, of  the
Portfolio's  total assets  are invested in  equity securities  of Latin American
issuers and in Sovereign Debt. For purposes of this Prospectus, unless otherwise
indicated,  Latin  America  consists  of  Argentina,  Bolivia,  Brazil,   Chile,
Colombia,  Costa  Rica,  Cuba,  the Dominican  Republic,  Ecuador,  El Salvador,
Guatemala, Honduras,  Mexico, Nicaragua,  Panama,  Paraguay, Peru,  Uruguay  and
Venezuela.  See "Additional  Investment Information  -- Foreign  Investment Risk
Factors" for a discussion  of the nature of  information publicly available  for
non-U.S.  companies. With  respect to  the Portfolio,  equity securities include
common and  preferred stocks,  convertible securities,  rights and  warrants  to
purchase  common  stocks,  equity  interests  in  trusts  or  partnerships,  and
American,  Global  or  other  types  of  Depositary  Receipts.  See  "Additional
Investment Information -- Depositary Receipts."
 
    The  Portfolio  focuses  its  investments  in  listed  equity  securities in
Argentina, Brazil, Chile and Mexico, the most developed capital markets in Latin
America. The Portfolio expects, under normal market conditions, to have at least
55% of its total assets invested in listed equity securities of issuers in these
four countries. In addition, the Portfolio actively invests in markets in  other
Latin  American countries such as Colombia, Peru and Venezuela. The Portfolio is
not limited in the extent to which  it may invest in any Latin American  country
and  intends to invest opportunistically as  markets develop. The portion of the
Portfolio's holdings in any Latin American country will vary from time to  time,
although  the portion of  the Portfolio's assets  invested in Chile  may tend to
vary less than the portions invested in other Latin American countries  because,
with   limited  exceptions,  capital  invested  in  Chile  currently  cannot  be
repatriated for one year. See  "Additional Investment Information --  Investment
Procedures:  Argentina, Brazil, Chile and Mexico" in the Statement of Additional
Information.
 
    The governments  of  some Latin  American  countries have  been  engaged  in
programs  of  selling  part  or  all of  their  stakes  in  government  owned or
controlled   enterprises   ("privatizations").   The   Adviser   believes   that
privatizations   may  offer  investors  opportunities  for  significant  capital
appreciation and intends to invest assets of the Portfolio in privatizations  in
appropriate  circumstances. In certain Latin  American countries, the ability of
foreign entities, such as the Portfolio, to participate in privatizations may be
limited by local law, or  the terms on which the  Portfolio may be permitted  to
participate  may be less advantageous than  those for local investors. There can
be no assurance that Latin American governments will continue to sell  companies
currently  owned or  controlled by  them or  that any  privatization programs in
which the Portfolio participates will be successful.
 
    Several Latin  American countries  have  adopted debt  conversion  programs,
pursuant  to which investors  may use Sovereign  Debt of a  country, directly or
indirectly, to make  investments in local  companies. The terms  of the  various
programs vary from country to country although each program includes significant
restrictions  on the application of the  proceeds received in the conversion and
on the remittance of profits on the investment and of the invested capital.  The
Portfolio  may  participate  in  Latin American  debt  conversion  programs. The
Adviser will evaluate opportunities to  enter into debt conversion  transactions
as they arise.
 
                                       24
<PAGE>
    Equity  securities in which the Portfolio  may invest include those that are
neither listed on a stock exchange  nor traded over-the-counter. As a result  of
the  absence of a public  trading market for these  securities, they may be less
liquid than publicly traded  securities. See "Additional Investment  Information
- -- Non-Publicly Traded Securities, Private Placements and Restricted Securities"
below.
 
    To  the  extent  that the  Portfolio's  assets  are not  invested  in equity
securities of Latin American issuers or in Sovereign Debt, the remainder of  the
assets  may be invested in  (i) debt securities of  Latin American issuers, (ii)
equity or  debt  securities of  corporate  or governmental  issuers  located  in
countries  outside  Latin America,  and  (iii) short-term  and  medium-term debt
securities of the  type described  under "Additional  Investment Information  --
Temporary  Investments" below.  The Portfolio's assets  may be  invested in debt
securities when the Portfolio believes that, based upon factors such as relative
interest rate  levels and  foreign exchange  rates, such  debt securities  offer
opportunities  for long-term capital appreciation. It is likely that many of the
debt securities  in  which  the  Portfolio will  invest  will  be  unrated.  The
Portfolio  may  invest up  to 20%  of its  total assets  in securities  that are
determined by the Adviser to be comparable to securities rated below  investment
grade  by  S&P  or Moody's  ("junk  bonds"). Such  lower-quality  securities are
regarded as being predominantly speculative  and involve significant risks.  See
"Additional Investment Information -- Lower Rated Debt Securities."
 
    The  Portfolio's  holdings  of lower-quality  debt  securities  will consist
predominantly of Sovereign Debt, much  of which trades at substantial  discounts
from  face value and  which may include Sovereign  Debt comparable to securities
rated as low as D by S&P or C by Moody's. The Portfolio may invest in  Sovereign
Debt  to  hold and  trade in  appropriate circumstances,  as well  as to  use to
participate in debt for equity conversion programs. The Portfolio will invest in
Sovereign  Debt  only  when  the  Portfolio  believes  such  investments   offer
opportunities  for long- term capital appreciation. Investment in Sovereign Debt
involves a high degree of risk  and such securities are generally considered  to
be  speculative in nature.  See "Additional Investment  Information -- Sovereign
Debt."
 
    For temporary defensive purposes, the Portfolio may invest less than 80%  of
its  total assets  in Latin  American equity  securities and  Sovereign Debt, in
which case the Portfolio may  invest in other equity  or debt securities or  may
invest  in  certain  short-term  (less  than  twelve  months  to  maturity)  and
medium-term (not greater than  five years to maturity)  debt securities or  hold
cash. See "Additional Investment Information -- Temporary Investments."
 
    The Portfolio may enter into forward foreign currency exchange contracts and
foreign  currency  futures contracts,  purchase and  write  (sell) put  and call
options  on  securities,  foreign  currency  and  on  foreign  currency  futures
contracts,  and enter into  stock index and interest  rate futures contracts and
options thereon. See  "Additional Investment Information."  There currently  are
limited  options and futures  markets for Latin  American currencies, securities
and indexes, and the  nature of the  strategies adopted by  the Adviser and  the
extent  to which those strategies  are used depends on  the development of those
markets. The Portfolio may also  from time to time  lend securities (but not  in
excess  of 20% of its  total assets) from its  portfolio to brokers, dealers and
financial institutions.  See  "Additional  Investment Information  --  Loans  of
Portfolio Securities."
 
    The  Portfolio will  not invest  more than  25% of  its total  assets in one
industry except and  to the extent,  and only for  such period of  time as,  the
Board of Directors determines in view of the considerations discussed below that
it is appropriate and in the best interest of the Portfolio and its shareholders
to invest more than 25% of the Portfolio's total assets in companies involved in
the    telecommunications    industry    or    financial    services   industry,
 
                                       25
<PAGE>
respectively. Since  the  securities markets  of  Latin American  countries  are
emerging  markets characterized  by a relatively  small number of  issues, it is
possible that one  or more markets  may on  occasion be dominated  by issues  of
companies  engaged in  these two  industries. In  addition, it  is possible that
government privatizations in certain  Latin American countries, which  currently
represent  a primary  source of  new issues in  many Latin  American markets and
often represent attractive  investment opportunities,  will occur  in these  two
industries.  As a result, the Portfolio has  adopted a policy under which it may
invest more  than 25%  of its  total assets  in securities  of issuers  in  such
industries.  The Portfolio would only take this action if the Board of Directors
determines that  the  Latin American  markets  are dominated  by  securities  of
issuers  in  such  industries and  that,  in  light of  the  anticipated return,
investment quality, availability and liquidity of the issues in such industries,
the Portfolio's ability to achieve its  investment objective would, in light  of
its investment policies and limitations, be materially adversely affected if the
Portfolios  were not able to invest greater than 25% of its total assets in such
industries. In the event that the Board of Directors permits greater than 25% of
the Portfolio's  total  assets  to  be invested  in  the  telecommunications  or
financial   services  industry,  the  Portfolio  may  be  exposed  to  increased
investment risks  peculiar  to that  industry.  The Portfolio  will  notify  its
shareholders  of any  decision by  the Board of  Directors to  permit (or cease)
investments  of  more  than  25%  of   the  Portfolio's  total  assets  in   the
telecommunications  or  financial services  industry. Such  notice will,  to the
extent applicable,  include  a  discussion of  any  increased  investment  risks
peculiar to such industry to which the Portfolio may be exposed.
 
    The  Portfolio intends to purchase and hold securities for long-term capital
appreciation and does not expect to  trade for short-term gain. Accordingly,  it
is  anticipated that the annual portfolio turnover rate normally will not exceed
50%, although  in  any  particular  year,  market  conditions  could  result  in
portfolio  activity at a  greater or lesser  rate than anticipated.  The rate of
portfolio turnover will  not be a  limiting factor when  the Portfolio deems  it
appropriate  to  purchase  or sell  securities.  However, the  U.S.  federal tax
requirement that the Portfolio derive less than 30% of its gross income from the
sale or disposition  of securities  held less than  three months  may limit  the
Portfolio's ability to dispose of its securities.
 
    Any remaining assets of the Portfolio not invested as described above may be
invested  in  certain  securities or  obligations  as set  forth  in "Additional
Investment Information" below.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    BORROWING AND OTHER  FORMS OF  LEVERAGE.   The Latin  American Portfolio  is
authorized  to borrow money from banks and  other entities in an amount equal to
up to 33  1/3% of  its total  assets (including  the amount  borrowed) less  all
liabilities  and indebtedness other than the borrowing, and may use the proceeds
of the borrowing for investment purposes or to pay dividends. Borrowing  creates
leverage  which  is  a  speculative characteristic.  Although  the  Portfolio is
authorized to  borrow,  it  will do  so  only  when the  Adviser  believes  that
borrowing  will benefit the  Portfolio after taking  into account considerations
such as the costs of borrowing  and the likely investment returns on  securities
purchased  with  borrowed monies.  Borrowing by  the  Portfolio will  create the
opportunity for increased net income but, at the same time, will involve special
risk considerations. Leveraging resulting  from borrowing will magnify  declines
as well as increases in the Portfolio's net asset value per share and net yield.
 
    The  Portfolio expects that all  of its borrowing will  be made on a secured
basis. The Portfolio's Custodian will  either segregate the assets securing  the
borrowing  for  the  benefit  of  the  lenders  or  arrangements  will  be  made
 
                                       26
<PAGE>
with a suitable sub-custodian. If assets  used to secure the borrowing  decrease
in  value, the Portfolio may be required  to pledge additional collateral to the
lender in the form of cash or securities to avoid liquidation of those assets.
 
    DEPOSITARY RECEIPTS.  The  Asian Equity, Global  Equity, Latin American  and
Japanese  Equity Portfolios may invest  in American Depositary Receipts ("ADRs")
and the Global  Equity and Latin  American Portfolios may  also invest in  other
Depositary  Receipts,  including Global  Depositary Receipts  ("GDRs"), European
Depositary Receipts ("EDRs") and other Depositary Receipts (which, together with
ADRs, GDRs and  EDRs, are  hereinafter collectively referred  to as  "Depositary
Receipts"),  to the extent that such  Depositary Receipts become available. ADRs
are  securities,  typically   issued  by   a  U.S.   financial  institution   (a
"depositary"),  that evidence  ownership interests  in a  security or  a pool of
securities issued by a  foreign issuer (the  "underlying issuer") and  deposited
with the depositary. ADRs include American Depositary Shares and New York Shares
and  may be "sponsored" or "unsponsored." Sponsored ADRs are established jointly
by a  depositary and  the underlying  issuer, whereas  unsponsored ADRs  may  be
established  by  a depositary  without participation  by the  underlying issuer.
GDRs, EDRs  and other  types  of Depositary  Receipts  are typically  issued  by
foreign depositaries, although they may also be issued by U.S. depositaries, and
evidence  ownership  interests in  a security  or pool  of securities  issued by
either a  foreign  or a  U.S.  corporation. Generally,  Depositary  Receipts  in
registered  form  are  designed  for  use  in  the  U.S.  securities  market and
Depositary Receipts in bearer  form are designed for  use in securities  markets
outside the United States. The Portfolio may invest in sponsored and unsponsored
Depositary  Receipts. For purposes  of the Portfolio's  investment policies, the
Portfolio's investments in Depositary Receipts will be deemed to be  investments
in the underlying securities.
 
    FOREIGN  INVESTMENT.   Investment in  securities of  foreign issuers  and in
foreign branches of domestic banks involves somewhat different investment  risks
than  those affecting securities of U.S.  domestic issuers. There may be limited
publicly available  information with  respect to  foreign issuers,  and  foreign
issuers  are not generally subject to uniform accounting, auditing and financial
and other reporting standards and requirements comparable to those applicable to
U.S. companies. There may also be less government supervision and regulation  of
foreign securities exchanges, brokers and listed companies than in the U.S. Many
foreign  securities markets  have substantially  less volume  than U.S. national
securities exchanges, and securities of some foreign issuers are less liquid and
more  volatile  than  securities  of  comparable  domestic  issuers.   Brokerage
commissions  and  other transaction  costs on  foreign securities  exchanges are
generally higher than in the U.S. Dividends and interest paid by foreign issuers
may be subject to  withholding and other foreign  taxes, which may decrease  the
net  return on foreign investments as compared to dividends and interest paid to
the Portfolios by U.S. companies, and it is not expected that a Portfolio or its
shareholders would be able to claim a credit for U.S. tax purposes with  respect
to  any  such  foreign  taxes.  See  "Taxes."  Additional  risks  include future
political and economic developments, the possibility that a foreign jurisdiction
might impose  or change  withholding taxes  on income  payable with  respect  to
foreign  securities, possible  seizure, nationalization or  expropriation of the
foreign issuer  or  foreign  deposits  and  the  possible  adoption  of  foreign
governmental  restrictions such  as exchange controls.  Many of  the emerging or
developing countries  may  have less  stable  political environments  than  more
developed  countries. Also, it may  be more difficult to  obtain a judgment in a
court outside the United States.
 
    Investments in securities of foreign  issuers are frequently denominated  in
foreign  currencies, and the Portfolios may temporarily hold uninvested reserves
in   bank    deposits   in    foreign   currencies.    Therefore,   the    value
 
                                       27
<PAGE>
of each Portfolio's assets as measured in U.S. dollars may be affected favorably
or unfavorably by changes in currency rates and in exchange control regulations,
and  the  Portfolios  may incur  costs  in connection  with  conversions between
various currencies.
 
    FORWARD FOREIGN CURRENCY EXCHANGE CONTRACTS.  Each Portfolio may enter  into
forward  foreign currency exchange contracts  ("forward contracts") that provide
for the purchase of  or sale of an  amount of a specified  currency at a  future
date. Purposes for which such contracts may be used include protecting against a
decline in a foreign currency against the U.S. dollar between the trade date and
settlement  date when a Portfolio purchases  or sells securities, locking in the
U.S. dollar value of  dividends declared on securities  held by a Portfolio  and
generally  protecting the  U.S. dollar value  of securities held  by a Portfolio
against exchange  rate  fluctuations. Such  contracts  may  also be  used  as  a
protective measure against the effects of fluctuating rates of currency exchange
and  exchange control regulations. While such forward contracts may limit losses
to a Portfolio as a  result of exchange rate  fluctuation, they will also  limit
any  gains that may  otherwise have been realized.  The Latin American Portfolio
may  also  enter  into  foreign  currency  futures  contracts.  See  "Investment
Objectives and Policies -- Forward Currency Exchange Contracts" in the Statement
of Additional Information. Except in circumstances where segregated accounts are
not  required by the 1940 Act and  the rules adopted thereunder, the Portfolio's
Custodian will  place  cash,  U.S. government  securities,  or  high-grade  debt
securities  into a segregated account  of a Portfolio in  an amount equal to the
value of such Portfolio's total assets committed to the consummation of  forward
foreign  currency exchange contracts.  If the value of  the securities placed in
the segregated account declines, additional cash or securities will be placed in
the account on a daily basis so that  the value of the account will be at  least
equal  to  the  amount of  such  Portfolio's  commitments with  respect  to such
contracts. See "Investment Objectives and  Policies -- Forward Foreign  Currency
Exchange Contracts" in the Statement of Additional Information.
 
    FUTURES  CONTRACTS AND  OPTIONS ON  FUTURES CONTRACTS.   In  order to remain
fully invested, and to  reduce transaction costs,  the Latin American  Portfolio
may   utilize  appropriate  securities  index   futures  contracts,  options  on
securities index futures contracts, appropriate interest rate futures  contracts
and  options on  interest rate  futures contracts  to a  limited extent. Because
transactions costs associated  with futures and  options may be  lower than  the
costs  of investing in securities directly, it is expected that the use of index
futures and options to  facilitate cash flows may  reduce a Portfolio's  overall
transactions  costs. The Portfolio may  sell indexed financial futures contracts
in anticipation of or during a market decline to attempt to offset the  decrease
in market value of securities in its portfolio that might otherwise result. When
the  Portfolio is not  fully invested and the  Adviser anticipates a significant
market advance,  it may  purchase stock  index futures  in order  to gain  rapid
market  exposure that may  in part or  entirely offset increases  in the cost of
securities that  it intends  to purchase.  In a  substantial majority  of  these
transactions,  the Portfolio will  purchase such securities  upon termination of
the futures position but under unusual market conditions, a futures position may
be terminated without  the corresponding purchase  of securities. The  Portfolio
will engage in futures and options transactions only for hedging purposes.
 
    The  Portfolio will engage only in  transactions in securities index futures
contracts, interest rate futures contracts and options thereon which are  traded
on  a recognized  securities or  futures exchange.  There currently  are limited
securities index  futures, interest  rate futures  and options  on such  futures
markets  in  many  countries,  particularly  emerging  countries  such  as Latin
American countries, and the nature of the strategies adopted by the Adviser  and
the  extent to which those strategies are used will depend on the development of
such markets.
 
                                       28
<PAGE>
    The Portfolio may enter into futures contracts and options thereon  provided
that not more than 5% of the Portfolio's total assets are required as deposit to
secure obligations under such contracts, and provided further that not more than
20%  of the Portfolio's total  assets, in the aggregate  are invested in futures
contracts and options transactions.
 
    The primary risks  associated with the  use of futures  and options are  (i)
imperfect  correlation between the change in market  value of the stocks held by
the Portfolio  and the  prices of  futures and  options relating  to the  stocks
purchased or sold by the Portfolio, and (ii) possible lack of a liquid secondary
market  for a futures  contract and the  resulting inability to  close a futures
position which could have an adverse impact on the Portfolio's ability to hedge.
The risk of  loss in  trading on  futures contracts  in some  strategies can  be
substantial, due both to the low margin deposits required and the extremely high
degree  of leverage involved in futures pricing. Gains and losses on futures and
options depend on the  Adviser's ability to predict  correctly the direction  of
stock  prices, interest rates, and other economic factors. In the opinion of the
Directors, the risk that  the Portfolio will  be unable to  close out a  futures
position  or options  contract will be  minimized by only  entering into futures
contracts or  options  transactions for  which  there  appears to  be  a  liquid
secondary  market. For more detailed  information about futures transactions see
"Investment Objectives and Policies" in the Statement of Additional Information.
 
    INVESTMENT FUNDS.  Some  emerging countries have  laws and regulations  that
currently  preclude  direct  foreign  investment  in  the  securities  of  their
companies. However, indirect foreign investment  in the securities of  companies
listed  and traded  on the  stock exchanges in  these countries  is permitted by
certain emerging countries through investment funds which have been specifically
authorized. The Latin American  Portfolio may invest  in these investment  funds
subject to the provisions of the Investment Company Act of 1940, as amended (the
"1940  Act"), and  other applicable  laws as  discussed below  under "Investment
Restrictions."  If  the  Portfolio  invests   in  such  investment  funds,   the
Portfolio's  shareholders will  bear not only  their proportionate  share of the
expenses of the  Portfolio (including  operating expenses  and the  fees of  the
Adviser),  but  also will  indirectly bear  similar  expenses of  the underlying
investment funds.
 
    Certain of the investment funds referred  to in the preceding paragraph  are
advised  by the Adviser.  The Portfolio may,  to the extent  permitted under the
1940 Act and  other applicable  law, invest in  these investment  funds. If  the
Portfolio  does elect to make an investment  in such an investment fund, it will
only purchase the securities of such investment fund in the secondary market.
 
    LOANS OF PORTFOLIO SECURITIES.   Each Portfolio may  lend its securities  to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing its net investment income. These loans must be secured
continuously  by cash or equivalent collateral or by a letter of credit at least
equal to the  market value  of the securities  loaned plus  accrued interest  or
income.  There may be risks of delay in  recovery of the securities or even loss
of rights  in  the  collateral  should  the  borrower  of  the  securities  fail
financially.  A  Portfolio  will  not enter  into  securities  loan transactions
exceeding in the aggregate 33 1/3% of the market value of the Portfolio's  total
assets  (exceeding in the aggregate 20% of  such value with respect to the Latin
American Portfolio). For more detailed information about securities lending, see
"Investment Objectives and Policies" in the Statement of Additional Information.
 
    LOWER RATED DEBT  SECURITIES.  The  Latin American Portfolio  may invest  in
lower rated or unrated debt securities, commonly referred to as "junk bonds." In
addition,    the    emerging   country    debt    securities   in    which   the
 
                                       29
<PAGE>
Portfolio may invest  are subject to  risk and will  not be required  to meet  a
minimum  rating  standard and  may  not be  rated.  Fixed income  securities are
subject to the  risk of  an issuer's inability  to meet  principal and  interest
payments  on the  obligations (credit  risk) and  may also  be subject  to price
volatility due to such factors  as interest rate sensitivity, market  perception
of  the  creditworthiness of  the issuer  and  general market  liquidity (market
risk).  Lower  rated  or  unrated  securities  are  more  likely  to  react   to
developments  affecting  market  and  credit risk  than  are  more  highly rated
securities, which react primarily to movements in the general level of  interest
rates.  The market values of fixed-income securities tend to vary inversely with
the level of interest rates. Yields and market values of lower rated and unrated
debt securities will fluctuate over time, reflecting not only changing  interest
rates but the market's perception of credit quality and the outlook for economic
growth.  When economic  conditions appear to  be deteriorating,  medium to lower
rated securities may  decline in  value due  to heightened  concern over  credit
quality,  regardless of prevailing interest rates.  Fluctuations in the value of
the Portfolio's investments will be reflected in the Portfolio's net asset value
per share. The  Adviser considers  both credit risk  and market  risk in  making
investment  decisions for the Portfolio. Investors should carefully consider the
relative risks  of investing  in lower  rated and  unrated debt  securities  and
understand   that  such  securities  are  not  generally  meant  for  short-term
investing.
 
    The U.S.  corporate  lower  rated  and unrated  debt  securities  market  is
relatively  new  and its  recent  growth paralleled  a  long period  of economic
expansion and an increase in merger, acquisition and leveraged buyout  activity.
Adverse  economic developments may  disrupt the market  for U.S. corporate lower
rated and unrated debt securities and for emerging country debt securities. Such
disruptions may  severely  affect  the ability  of  issuers,  especially  highly
leveraged  issuers,  to  service  their  debt  obligations  or  to  repay  their
obligations upon maturity. In addition, the secondary market for lower rated and
unrated debt securities, which is concentrated in relatively few market  makers,
may  not be as liquid as the  secondary market for more highly rated securities.
As a result, the Adviser could find  it more difficult to sell these  securities
or  may  be able  to  sell the  securities  only at  prices  lower than  if such
securities were widely traded. In addition there may be limited trading  markets
for  debt securities of  issuers located in  emerging countries. Prices realized
upon  the  sale  of  such  lower  rated  or  unrated  securities,  under   these
circumstances,  may be less than the  prices used in calculating the Portfolio's
net asset value.
 
    Prices for  lower rated  and  unrated debt  securities  may be  affected  by
legislative  and regulatory developments. These  laws could adversely affect the
Portfolio's net asset value and  investment practices, the secondary market  for
lower  rated and unrated debt securities,  the financial condition of issuers of
such securities  and the  value  of outstanding  lower  rated and  unrated  debt
securities.  For example, U.S. federal  legislation requiring the divestiture by
federally insured savings and  loan associations of  their investments in  lower
rated  and unrated debt securities and limiting the deductibility of interest by
certain corporate issuers of lower  rated and unrated debt securities  adversely
affected the market in recent years.
 
    Lower  rated or unrated debt obligations also present risks based on payment
expectations. If an issuer calls  the obligations for redemption, the  Portfolio
may  have to replace the security with a lower yielding security, resulting in a
decreased return  for investors.  If the  Portfolio experiences  unexpected  net
redemptions,  it may be forced to sell its higher rated securities, resulting in
a decline in the overall credit quality of the Portfolio's investment  portfolio
and  increasing the exposure  of the Portfolio  to the risks  of lower rated and
unrated debt securities.
 
                                       30
<PAGE>
    MONEY MARKET INSTRUMENTS.  The Portfolios  are permitted to invest in  money
market  instruments,  although  each  Portfolio  intends  to  stay  invested  in
securities  satisfying  their  primary   investment  objective  to  the   extent
practical.  Each  Portfolio  may  make money  market  investments  pending other
investment or settlement  for liquidity,  or in adverse  market conditions.  The
money market investments permitted for the Portfolios include obligations of the
U.S.  Government and its agencies  and instrumentalities, obligations of foreign
sovereignties,  other   debt  securities,   commercial  paper   including   bank
obligations,  certificates  of  deposit  (including  Eurodollar  certificates of
deposit) and repurchase  agreements. For more  detailed information about  these
money  market investments,  see "Description of  Securities and  Ratings" in the
Statement of Additional Information.
 
    NON-PUBLICLY  TRADED   SECURITIES,   PRIVATE   PLACEMENTS   AND   RESTRICTED
SECURITIES.    The  International Small  Cap  Portfolio and  the  Latin American
Portfolio may invest in securities that  are neither listed on a stock  exchange
nor   traded  over-the-counter,  including  privately  placed  securities.  Such
unlisted equity securities may involve a higher degree of business and financial
risk that can  result in substantial  losses. As a  result of the  absence of  a
public  trading  market  for these  securities,  they  may be  less  liquid than
publicly traded securities. Although these securities may be resold in privately
negotiated transactions, the prices realized from these sales could be less than
those originally paid by the Portfolio or  less than what may be considered  the
fair  value of such securities. Further, more companies whose securities are not
publicly traded  may  not  be  subject to  the  disclosure  and  other  investor
protection  requirements  which might  be  applicable if  their  securities were
publicly traded. If  such securities  are required  to be  registered under  the
securities  laws of one or more jurisdictions before being resold, the Portfolio
may be required to bear the expenses of registration. As a general matter,  each
Portfolio may not invest more than 15% of its net assets in illiquid securities,
including  securities for which there is  no readily available secondary market,
nor more than 10%  of its total  assets in securities  that are restricted  from
sale  to  the public  without registration  ("Restricted Securities")  under the
Securities Act of 1933, as amended (the "1933 Act"). Nevertheless, to the extent
it can do so consistent with the foregoing limits, each Portfolio may invest  up
to 25% of its total assets in Restricted Securities that can be offered and sold
to  qualified  institutional  buyers  under  Rule  144A  under  that  Act ("144A
Securities"). The Board of Directors has adopted guidelines and delegated to the
Adviser, subject  to  the supervision  of  the  Board of  Directors,  the  daily
function  of determining and  monitoring the liquidity  of 144A securities. Rule
144A securities may become  illiquid if qualified  institutional buyers are  not
interested  in acquiring the securities.  Investors should note that investments
of 5% of a Portfolio's total assets may be considered a speculative activity and
may involve greater risk and expense to the Portfolio.
 
    OPTIONS TRANSACTIONS.  The Latin American Portfolio may seek to increase its
return or  may hedge  all or  a  portion of  its portfolio  investments  through
options  with  respect to  securities  in which  the  Portfolio may  invest. The
Portfolio will engage  in transactions  in such options  which are  traded on  a
recognized  securities or futures exchange and in over-the-counter options where
the option counterparty has a minimum net worth of $20 million. There  currently
are  limited  options markets  in emerging  countries, including  Latin American
countries and the nature of the strategies adopted by the Adviser and the extent
to which those strategies are used will depend on the development of such option
markets.
 
    The Latin American  Portfolio may  write (i.e., sell)  covered call  options
which give the purchaser the right to buy the underlying security covered by the
option  from the Portfolio at the stated exercise price. A "covered" call option
means that so long as the Portfolio is obligated as the writer of the option, it
will own (i) the
 
                                       31
<PAGE>
underlying securities subject to the  option, or (ii) securities convertible  or
exchangeable  without  the  payment  of any  consideration  into  the securities
subject to  the option.  As  a matter  of operating  policy,  the value  of  the
underlying  securities on which options will be written at any one time will not
exceed 5% of  the total assets  of the Portfolio.  In addition, as  a matter  of
operating  policy, the Portfolio  will neither purchase or  write put options on
securities nor purchase call  options on securities  (except in connection  with
closing purchase transactions).
 
    The  Latin  American  Portfolio will  receive  a premium  from  writing call
options, which increases the  Portfolio's return on  the underlying security  in
the  event  the option  expires unexercised  or is  closed out  at a  profit. By
writing a  call, the  Portfolio will  limit its  opportunity to  profit from  an
increase in the market value of the underlying security above the exercise price
of  the option for as long as the Portfolio's obligation as writer of the option
continues. Thus, in some  periods the Portfolio will  receive less total  return
and in other periods greater total return from writing covered call options than
it  would have received from  its underlying securities had  it not written call
options.
 
    The Latin  American  Portfolio  may  also write  (i.e.,  sell)  covered  put
options.  By selling a covered put option, the Portfolio incurs an obligation to
buy the security  underlying the option  from the  purchaser of the  put at  the
option's exercise price at any time during the option period, at the purchaser's
election  (certain options written  by the Portfolio will  be exercisable by the
purchaser only on a specific date). Generally, a put option is "covered" if  the
Portfolio  maintains cash, U.S.  Government securities or  other high grade debt
obligations equal to the exercise price of the option or if the Portfolio  holds
a  put option on the same underlying  security with a similar or higher exercise
price. The  Portfolio may  sell put  options  to receive  the premiums  paid  by
purchasers  and to close out  a long put option  position. In addition, when the
Adviser wishes to purchase a security at  a price lower than its current  market
price, the Portfolio may write a covered put at an exercise price reflecting the
lower purchase price sought.
 
    The Portfolio may also purchase put or call options on individual securities
or baskets of securities. When the Portfolio purchases a call option it acquires
the  right to  buy a  designated security at  a designated  price (the "exercise
price"), and when the Portfolio purchases a put option it acquires the right  to
sell  a designated security at  the exercise price, in each  case on or before a
specified date (the "termination date"), usually not more than nine months  from
the  date the option is issued. The Portfolio may purchase call options to close
out a covered call position or to protect against an increase in the price of  a
security  it anticipates purchasing.  The Portfolio may  purchase put options on
securities which it holds in its  portfolio only to protect against an  increase
in the price of a security it anticipates purchasing. The Portfolio may purchase
put options on securities which it holds in its portfolio only to protect itself
against  a decline in the value of the  security. If the value of the underlying
security were to fall below the exercise price of the put purchased in an amount
greater than  the premium  paid for  the option,  the Portfolio  would incur  no
additional  loss.  The Portfolio  may  also purchase  put  options to  close out
written put  positions in  a  manner similar  to  call option  closing  purchase
transactions.  There are no other limits  on the Portfolio's ability to purchase
call and put options.
 
    The primary  risks associated  with the  use of  options are  (i)  imperfect
correlation  between the change  in market value  of the securities  held by the
Portfolio and the prices of options relating to the securities purchased or sold
by the Portfolio; and  (ii) possible lack  of a liquid  secondary market for  an
option.  Options that  are not  traded on  an exchange  (OTC options)  are often
considered illiquid  and  may be  difficult  to value.  In  the opinion  of  the
Adviser,  the risk that  that Portfolio will  be unable to  close out an options
contract will be minimized by only entering into options transactions for  which
there appears to be a liquid secondary market.
 
                                       32
<PAGE>
    REPURCHASE  AGREEMENTS.  Each Portfolio may enter into repurchase agreements
with brokers, dealers or  banks that meet the  credit guidelines established  by
the  Fund's Board of Directors. In a  repurchase agreement, the Portfolio buys a
security from a seller  that has agreed  to repurchase it  at a mutually  agreed
upon  date and price, reflecting the interest rate effective for the term of the
agreement. The term of  these agreements is usually  from overnight to one  week
and  never exceeds  one year.  Repurchase agreements  may be  viewed as  a fully
collateralized loan  of money  by the  Portfolio to  the seller.  The  Portfolio
always  receives securities with a  market value at least  equal to the purchase
price (including accrued interest) as  collateral, and this value is  maintained
during  the term  of the  agreement. If the  seller defaults  and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings  are
commenced  with  respect to  the seller,  the  Portfolio's realization  upon the
collateral may  be  delayed or  limited.  The aggregate  of  certain  repurchase
agreements  and  certain  other  investments  is  limited  as  set  forth  under
"Investment Limitations."
 
SHORT SALES
 
    The Latin American  Portfolio may from  time to time  sell securities  short
without  limitation, although  initially the Portfolio  does not  intend to sell
securities short. A  short sale is  a transaction in  which the Portfolio  would
sell  securities it does not own (but has borrowed) in anticipation of a decline
in the market price of  securities. When the Portfolio  makes a short sale,  the
proceeds  it receives from the sale will be held on behalf of a broker until the
Portfolio replaces the  borrowed securities.  To deliver the  securities to  the
buyer,  the  Portfolio will  need  to arrange  through  a broker  to  borrow the
securities and, in so doing, the Portfolio will become obligated to replace  the
securities  borrowed at their market price  at the time of replacement, whatever
that price  may be.  The Portfolio  may  have to  pay a  premium to  borrow  the
securities  and must  pay any  dividends or  interest payable  on the securities
until they are replaced.
 
    The Portfolio's obligation to replace the securities borrowed in  connection
with  a short sale will be secured  by collateral deposited with the broker that
consists of cash, U.S.  Government Securities or other  liquid, high grade  debt
obligations.  In addition, the Portfolio will place in a segregated account with
its Custodian an amount of cash, U.S. Government Securities or other liquid high
grade debt obligations equal to the  difference, if any, between (1) the  market
value  of the securities sold at the time they were sold short and (2) any cash,
U.S. Government Securities or other liquid high grade debt obligations deposited
as collateral with the broker in  connection with the short sale (not  including
the  proceeds of the short  sale). Short sales by  the Portfolio involve certain
risks and special considerations. Possible  losses from short sales differ  from
losses that could be incurred from a purchase of a security, because losses from
short  sales may be unlimited, whereas losses  from purchases can equal only the
total amount invested.
 
    SOVEREIGN DEBT.   The Latin American  Portfolio's holdings of  lower-quality
debt  securities will  consist predominantly  of Sovereign  Debt, much  of which
trades at substantial  discounts from face  value. The Portfolio  may invest  in
Sovereign  Debt of  emerging market countries  to hold and  trade in appropriate
circumstances  and  to  participate  in  debt  to  equity  conversion  programs.
Investment  in Sovereign Debt involves a high degree of risk and such securities
are generally  considered  speculative in  nature.  The issuer  or  governmental
authorities  that control  the repayment  of Sovereign Debt  may not  be able or
willing to repay the principal and/or  interest when due in accordance with  the
terms  of  such  debt. A  sovereign  debtor's  willingness or  ability  to repay
principal and interest due in  a timely manner may  be affected by, among  other
factors,  its  cash flow  situation,  the extent  of  its foreign  reserves, the
availability of sufficient foreign  exchange on the date  a payment is due,  the
relative  size  of  the debt  service  burden to  the  economy as  a  whole, the
sovereign debtor's policy towards the
 
                                       33
<PAGE>
International Monetary Fund (the "IMF") and the political constraints to which a
sovereign debtor may  be subject.  Sovereign debtors  may also  be dependent  on
expected  disbursements  from  foreign  governments,  multilateral  agencies and
others abroad to  reduce principal and  interest arrearages on  their debt.  The
commitment  on the part of  these governments, agencies and  others to make such
disbursements may  be  conditioned on  a  sovereign debtor's  implementation  of
economic  reforms and/or  economic performance  and the  timely service  of such
debtor's obligations. Failure to implement such reforms, achieve such levels  of
economic  performance or repay principal or interest  when due may result in the
cancellation of such third parties' commitments  to lend funds to the  sovereign
debtor,  which may further impair such debtor's ability or willingness to timely
service its debts. In certain instances,  the Portfolio may invest in  Sovereign
Debt  that is  in default as  to payments  of principal and/or  interest. To the
extent the Portfolio is holding any non-performing Sovereign Debt, it may  incur
additional  expenses  in  connection  with  any  restructuring  of  the issuer's
obligations or in otherwise enforcing its rights thereunder.
 
    TEMPORARY INVESTMENTS.  During periods in which the Adviser believes changes
in economic, financial or political conditions make it advisable, for  temporary
defensive  purposes  the Latin  American Portfolio  may  reduce its  holdings in
equity and other  securities and  may invest  in certain  short-term (less  than
twelve  months  to maturity)  and medium-term  (not greater  than five  years to
maturity) debt securities or may hold cash. The short-term and medium-term  debt
securities  in which the Portfolio may invest  consist of (a) obligations of the
United States  or emerging  country  governments (Latin  American  governments),
their  respective  agencies or  instrumentalities;  (b) bank  deposits  and bank
obligations (including  certificates  of  deposit, time  deposits  and  bankers'
acceptances)  of United States or emerging  country banks (Latin American banks)
denominated in any currency; (c) floating rate securities and other  instruments
denominated  in any currency  issued by international  development agencies; (d)
finance company and  corporate commercial paper  and other short-term  corporate
debt  obligations  of United  States  and emerging  country  corporations (Latin
American corporations) meeting the Portfolio's credit quality standards; and (e)
repurchase agreements  with  banks  and  broker-dealers  with  respect  to  such
securities.  See "Additional  Investment Information  -- Repurchase Agreements."
For temporary  defensive  purposes, the  Portfolio  intends to  invest  only  in
short-term  and medium-term debt  securities that the Adviser  believes to be of
high quality,  i.e., subject  to relatively  low  risk of  loss of  interest  or
principal  (there  is currently  no rating  system for  debt securities  in most
emerging countries, including most Latin American countries.)
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  Each Portfolio of the Fund may
purchase securities  on  a  when-issued  or  delayed  delivery  basis.  In  such
transactions,  instruments are bought with payment  and delivery taking place in
the future in order to secure what is considered to be an advantageous yield  or
price  at  the  time of  the  transaction.  Delivery of  and  payment  for these
securities may take as long  as a month or more  after the date of the  purchase
commitment  but will take place no more than 120 days after the trade date. Each
Portfolio will maintain with the Custodian a separate account with a  segregated
portfolio  of  high-grade debt  securities or  equity securities  or cash  in an
amount at  least equal  to these  commitments. The  payment obligation  and  the
interest  rates that  will be received  are each  fixed at the  time a Portfolio
enters into  the commitment  and  no interest  accrues  to the  Portfolio  until
settlement. Thus, it is possible that the market value at the time of settlement
could  be higher or lower  than the purchase price  if, among other factors, the
general level of  interest rates has  changed. It  is a current  policy of  each
Portfolio  not  to  enter  into  when-issued  commitments  or  delayed  delivery
securities exceeding in the aggregate 15% of the market value of the Portfolio's
total assets  less liabilities,  other  than the  obligations created  by  these
commitments.
 
                                       34
<PAGE>
                             INVESTMENT LIMITATIONS
 
    Each  Portfolio,  except  the  Latin American  Portfolio,  is  a diversified
investment company under the 1940 Act and is therefore subject to the  following
limitations:  (a) as to 75% of its total assets, a Portfolio may not invest more
than 5%  of  its total  assets  in the  securities  of any  one  issuer,  except
obligations  of the U.S. Government and  its agencies and instrumentalities, and
(b) a Portfolio may not own more  than 10% of the outstanding voting  securities
of  any one issuer. The Latin American Portfolio is a non-diversified investment
company under the 1940 Act, which means that the Latin American Portfolio is not
limited by  the 1940  Act in  the proportion  of its  total assets  that may  be
invested  in  the  obligations of  a  single  issuer. Thus,  the  Latin American
Portfolio may invest a greater proportion of its total assets in the  securities
of a smaller number of issuers and, as a result, will be subject to greater risk
with  respect  to  their  respective portfolio  securities.  The  Latin American
Portfolio, however,  intends to  comply  with the  diversification  requirements
imposed by the Internal Revenue Code of 1986, as amended, for qualification as a
regulated investment company. See "Taxes."
 
    Each  Portfolio also operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of  the
holders  of a majority  of such Portfolio's  outstanding shares. See "Investment
Limitations" in  the  Statement of  Additional  Information. In  addition,  each
Portfolio  operates  under  certain  non-fundamental  investment  limitations as
described below and in the  Statement of Additional Information. Each  Portfolio
may  not  (i) enter  into repurchase  agreements  with more  than seven  days to
maturity if, as a result, more than  15% of the market value of the  Portfolio's
net assets would be invested in these agreements and other investments for which
market  quotations are  not readily available  or which  are otherwise illiquid;
(ii) borrow money, except  from banks for  extraordinary or emergency  purposes,
and then only in amounts up to 10% of the value of the Portfolio's total assets,
taken  at cost at the time of borrowing, or purchase securities while borrowings
exceed 5%  of its  total assets,  except  the Latin  American Portfolio  is  not
subject to such limits on borrowing and may borrow from banks and other entities
in  amounts not in excess  of 33 1/3% of its  total assets (including the amount
borrowed) less liabilities;  (iii) mortgage,  pledge or  hypothecate any  assets
except  in connection with any such borrowing in  amounts up to 10% of the value
of the Portfolio's net  assets at the  time of borrowing;  (iv) invest in  fixed
time  deposits with  a duration of  over seven  calendar days; or  (v) invest in
fixed time deposits with a duration of from two business days to seven  calendar
days if more than 10% of the Portfolio's total assets would be invested in these
deposits.
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT  ADVISER.  Morgan Stanley Asset Management Inc. is the Investment
Adviser and Administrator of  the Fund and each  of its portfolios. The  Adviser
provides  investment advice  and portfolio  management services,  pursuant to an
Investment Advisory  Agreement and,  subject to  the supervision  of the  Fund's
Board  of  Directors,  makes  each  of  the  Portfolio's  day-to-day  investment
decisions, arranges for  the execution of  portfolio transactions and  generally
manages  each  of the  Portfolio's  investments. Set  forth  below as  an annual
percentage of average daily  net assets are the  management fees payable to  the
Adviser  quarterly by  each Portfolio  pursuant to  the terms  of the Investment
Advisory  Agreement.  The  fees  of  each  of  the  Portfolios,  which   involve
international  investments, are higher  than those of  most investment companies
because they involve international investments but the Adviser believes the fees
are   comparable    to   those    of   investment    companies   with    similar
 
                                       35
<PAGE>
objectives.  The Adviser has agreed to a reduction in the fees payable to it and
to reimburse the Portfolios, if necessary, if such fees would cause total annual
operating expenses of  the Portfolios to  exceed the maximums  set forth in  the
table below.
 
<TABLE>
<CAPTION>
                                                            MAXIMUM TOTAL ANNUAL
                                                                  OPERATING
                                                             EXPENSES AFTER FEE
                                            MANAGEMENT             WAIVERS
                                            ABSENT FEE      ---------------------
               PORTFOLIO                      WAIVERS       CLASS A      CLASS B
- ----------------------------------------    -----------     --------     --------
<S>                                         <C>             <C>          <C>
Global Equity                                    0.80%        1.00%        1.25%
International Equity                             0.80%        1.00%        1.25%
International Small Cap                          0.95%        1.15%         N/A
Asian Equity                                     0.80%        1.00%        1.25%
European Equity                                  0.80%        1.00%        1.25%
Japanese Equity                                  0.80%        1.00%        1.25%
Latin American                                   1.10%        1.70%        1.95%
</TABLE>
 
    The  Adviser, with  principal offices  at 1221  Avenue of  the Americas, New
York, New  York  10020,  conducts a  worldwide  portfolio  management  business,
provides  a broad  range of  portfolio management  services to  customers in the
United States and abroad. At December  31, 1995, the Adviser, together with  its
affiliated    asset   management   companies,   managed   investments   totaling
approximately $57.4 billion, including approximately $41.9 billion under  active
management  and  $15.5  billion as  Named  Fiduciary or  Fiduciary  Adviser. See
"Management of the Fund" in the Statement of Additional Information.
 
    PORTFOLIO  MANAGERS    The  following  individuals  have  primary  portfolio
management responsibility for the Portfolios noted below:
 
    GLOBAL  EQUITY PORTFOLIO  -- FRANCES  CAMPION.   Frances Campion  joined the
Adviser in January 1990 as a Global  Equity Fund Manager and is now a  Principal
of  Morgan Stanley.  Her responsibilities include  day to day  management of the
Global Equity product.  Prior to  joining the Adviser,  Ms. Campion  was a  U.S.
equity  analyst with Lombard Odler Limited  where she had responsibility for the
management of global  portfolios. Ms.  Campion has ten  years global  investment
experience. She is a graduate of University of College, Dublin.
 
    INTERNATIONAL EQUITY PORTFOLIO -- DOMINIC CALDECOTT.  Dominic Caldecott is a
Managing  Director and  is responsible for  research and stock  selection in the
Pacific Basin and has  been primarily responsible  for managing the  Portfolio's
assets  since its inception. He has ten years professional experience, primarily
in Tokyo, Hong Kong, and Seoul. Prior to joining Morgan Stanley, he worked  with
GT  Management  Group in  Tokyo  and Hong  Kong,  specializing in  Pacific Basin
investment management. He became a Vice  President of Morgan Stanley in 1987,  a
principal  in 1989,  and a Managing  Director in  1991. He is  responsible for a
number of Pacific Basin investment programs  for clients of Morgan Stanley.  Mr.
Caldecott is a graduate of New College, Oxford, England.
 
    INTERNATIONAL  SMALL CAP PORTFOLIO -- MARGARET NAYLOR.  Margaret Naylor is a
Principal of Morgan Stanley  and works with Dominic  Caldecott on Pacific  Basin
research  and stock selection. She joined the Adviser in March 1987 and has been
primarily responsible for managing the  Portfolio's assets since December  1992.
Prior
 
                                       36
<PAGE>
to  joining  the Adviser  she spent  three  years at  the Trade  Policy Research
Centre, an independent research unit. Ms. Naylor is a graduate of the University
of York. Ms. Naylor became a Vice President of Morgan Stanley in 1993.
 
    ASIAN EQUITY PORTFOLIO -- EAN WAH CHIN.  Ean Wah Chin is a Managing Director
of Morgan Stanley, and is responsible  for the Adviser's regional Asia  ex-Japan
operations  based in Singapore. She has  been primarily responsible for managing
the Portfolio's assets since its inception.  Prior to joining Morgan Stanley  in
1986,  Ms. Chin spent eight  years with the Monetary  Authority of Singapore and
the Government of Singapore  Investment Corporation, where  she was a  portfolio
manager  of one of the largest portfolios in Asia. Ms. Chin was an ASEAN scholar
educated at the University of Singapore.
 
    EUROPEAN EQUITY PORTFOLIO -- ROBERT  SARGENT.  Robert Sargent joined  Morgan
Stanley  International in  May, 1986,  and transferred  to the  Adviser in June,
1987. Mr. Sargent is now  a Principal of Morgan  Stanley and has been  primarily
responsible for managing the Portfolio's assets since its inception. As the fund
manager with primary responsibility for continental European stock selection and
portfolio  management,  Mr.  Sargent  is  closely  involved  with  the Adviser's
fundamental research effort and  company visiting program. He  is a graduate  of
York University, Toronto, Canada.
 
    JAPANESE    EQUITY   PORTFOLIO    --   DOMINIC    CALDECOTT   AND   KUNIHIKO
SUGIO.  Information about Mr.  Caldecott is included under International  Equity
Portfolio  above. Mr. Caldecott is responsible  for research and stock selection
in the  Pacific  Basin and  has  been  primarily responsible  for  managing  the
Portfolio's  assets since  its inception. Kunihiko  Sugio joined  the Adviser in
December 1993  as  a  Vice  President  and  manages  dedicated  Japanese  equity
portfolios.  He  has been  primarily  responsible for  managing  the Portfolio's
assets since its  inception. Prior  to joining  Morgan Stanley,  he worked  with
Baring  International Investment Management, Tokyo, where  he was a Director and
fund manager. He graduated from Wakayama Kokuritsu University.
 
    LATIN AMERICAN  PORTFOLIO --  ROBERT  L. MEYER.    Robert Meyer  joined  the
Adviser  in  1989  and  is  now a  Principal  of  Morgan  Stanley,  with primary
responsibility for the Adviser's investments in all of Latin America and Israel.
He has had primary responsibility for managing the Portfolio's assets since  its
inception.  Robert is co-manager of the  Latin American Discovery Fund, Inc. and
worked previously  in the  U.S. equity  group at  the Adviser.  He was  born  in
Argentina  and has a B.A.  in Economics and Political  Science from Yale College
and a J.D. from Harvard Law School.
 
    ADMINISTRATOR.   The  Adviser also  provides  the Fund  with  administrative
services  pursuant to an  Administration Agreement. The  services provided under
the Administration Agreement are subject to the supervision of the Officers  and
Board  of Directors of the Fund and include day-to-day administration of matters
related to the  corporate existence  of the  Fund, maintenance  of its  records,
preparation  of  reports,  supervision  of  the  Fund's  arrangements  with  its
custodian, assistance in the preparation  of the Fund's registration  statements
under  federal and state  laws. The Administration  Agreement also provides that
the Administrator through its agents  will provide the Fund dividend  disbursing
and   transfer  agent  services.  For  its  services  under  the  Administration
Agreement, the Fund  pays the Adviser  a monthly  fee which on  an annual  basis
equals 0.15% of the average daily net assets of each Portfolio.
 
    Under  an agreement between  the Adviser and The  Chase Manhattan Bank, N.A.
("Chase"), Chase  provides certain  administrative services  to the  Fund. In  a
merger  completed on September 1, 1995, Chase succeeded to all of the rights and
obligations under the  U.S. Trust Administration  Agreement between the  Adviser
and the
 
                                       37
<PAGE>
United  States Trust Company of New York  ("U.S. Trust"), pursuant to which U.S.
Trust had  agreed  to  provide  certain administrative  services  to  the  Fund.
Pursuant to a delegation clause in the U.S. Trust Administration Agreement, U.S.
Trust  delegated  its  administration  responsibilities  to  Chase  Global Funds
Services Company  ("CGFSC"), formerly  known as  Mutual Funds  Service  Company,
which  after the merger with Chase is a subsidiary of Chase and will continue to
provide certain administrative services to the Fund. The Adviser supervises  and
monitors  such administrative services provided  by CGFSC. The services provided
under the Administration Agreement and  the U.S. Trust Administration  Agreement
are  also subject to the supervision of the  Board of Directors of the Fund. The
Board of Directors of the Fund has approved the provision of services  described
above pursuant to the Administration Agreement and the U.S. Trust Administration
Agreement  as being in the best interests  of the Fund. CGFSC's business address
is  73  Tremont  Street,   Boston,  Massachusetts  02108-3913.  For   additional
information   regarding  the   Administration  Agreement,  or   the  U.S.  Trust
Administration Agreement,  see "Management  of  the Fund"  in the  Statement  of
Additional Information.
 
LOCAL ADMINISTRATORS FOR THE LATIN AMERICAN PORTFOLIO
 
    The  Portfolio has  entered into  an administration  agreement (the "Chilean
Administration Agreement") with  Bice Chileconsult Agente  de Valores S.A.  (the
"Chilean  Administrator"), a Chilean corporation,  pursuant to which the Chilean
Administrator acts as the Portfolio's  legal representative in Chile. Under  the
Chilean  Administration  Agreement, the  Chilean Administrator  performs various
services for the Portfolio, including making and obtaining all exchange  control
filings  and approvals required for the Portfolio to effect investment and other
transactions in Chile  and to remit  moneys and other  assets outside of  Chile,
obtaining  from the relevant authorities in  Chile all confirmations or consents
relating to  the tax  status of  the Portfolio  and all  tax rebates  and  other
payments   which  may  be  due  to  the  Portfolio,  and  performing  all  other
administrative duties in Chile  required by Chilean  law or Chilean  authorities
through  instructions  or regulations  to be  performed.  For its  services, the
Chilean Administrator is paid an annual fee by the Fund equal to the greater  of
0.125%  of  the  Portfolio's average  weekly  net  assets invested  in  Chile or
$20,000, paid monthly. Unless terminated by  the Fund's Board of Directors  upon
60  days' prior written notice,  or by the Chilean  Administration upon 90 days'
prior  written  notice,  the  Chilean  Administration  Agreement  will  continue
automatically from year to year.
 
    The Latin American Portfolio is required under Brazilian law to have a local
administrator  in  Brazil.  Unibanco-Uniao  (the  "Brazilian  Administrator"), a
Brazilian corporation, acts as the Portfolio's Brazilian administrator  pursuant
to  an agreement with the  Portfolio (the "Brazilian Administration Agreement").
Under  the  Brazilian  Administration  Agreement,  the  Brazilian  Administrator
performs   various  services   for  the   Portfolio,  including   effecting  the
registration of the Portfolio's foreign capital with the Central Bank of Brazil,
effecting  all  foreign  exchange   transactions  related  to  the   Portfolio's
investments  in Brazil and obtaining all approvals required for the Portfolio to
make remittances of  income and capital  gains and for  the repatriation of  the
Portfolio's  investments  pursuant  to  Brazilian  law.  For  its  services, the
Brazilian Administrator is paid an annual fee equal to 0.125% of the Portfolio's
average weekly net assets invested in Brazil, paid monthly. The principal office
of the Brazilian Administrator  is located at Avenida  Eusebio Matoso, 891,  Sao
Paulo,  S.P., Brazil. The Brazilian  Administration Agreement is terminable upon
six months' notice by either party; the Brazilian Administrator may be  replaced
only by an entity authorized to act as a joint manager of a managed portfolio of
bonds and securities under Brazilian law.
 
    The  Portfolio is required under Colombian law to have a local administrator
in Colombia. CitiTrust S.A. (the  "Colombian Administrator"), a Colombian  Trust
Company, acts as the Portfolio's Colombian administrator
 
                                       38
<PAGE>
pursuant  to an agreement with the  Portfolio (the "Colombian Agreement"). Under
the Colombian Agreement, the  Columbian Administrator performs various  services
for the Portfolio, including effecting all foreign exchange transactions related
to  the Portfolio's foreign capital with the Central Bank of Colombia, effecting
all foreign  exchange transactions  related to  the Portfolio's  investments  in
Colombia  and  obtaining  all  approvals  required  for  the  Portfolio  to make
remittances of income and capital gains and the repatriation of the  Portfolio's
investment   pursuant  to  Colombian  law.   For  its  services,  the  Colombian
Administrator is paid  an annual fee  of $1,000 plus  .20% per transaction.  The
principal   office  of  the  Colombian  Administrator  is  located  at  Sociedad
Fiduciaria International S.A., 8-89, Piso 2,  Santa Fe de Bogota, Colombia.  The
Colombian  Agreement is  terminable upon  30 days'  notice by  either party. The
Colombian Administrator may be replaced only by an entity authorized to act as a
joint manager of  a managed portfolio  of bonds and  securities under  Colombian
law.
 
    DIRECTORS  AND OFFICERS.  Pursuant to  the Fund's Articles of Incorporation,
the Board of Directors  decides upon matters of  general policy and reviews  the
actions  of the Fund's  Adviser, Administrator and  Distributor. The officers of
the Fund conduct and supervise its daily business operations.
 
    DISTRIBUTOR.   Morgan Stanley  serves as  the exclusive  Distributor of  the
shares  of  the Fund.  Under its  Distribution Agreement  with the  Fund, Morgan
Stanley sells  shares  of each  Portfolio  upon the  terms  and at  the  current
offering  price described in this Prospectus. Morgan Stanley is not obligated to
sell any certain number of shares of any Portfolio and receives no  compensation
for its distribution services.
 
    The  Portfolios currently offer  only the classes of  shares offered by this
Prospectus. The Portfolios may in the future offer one or more classes of shares
with features, distribution expenses or  other expenses that are different  from
those of the classes currently offered.
 
    The  Fund has  adopted a Plan  of Distribution  with respect to  the Class B
shares of each Multiclass  Portfolio pursuant to Rule  12b-1 under the 1940  Act
(each,  a "Plan"). Under each Plan, the  Distributor is entitled to receive from
each Multiclass Portfolio a  distribution fee, which is  accrued daily and  paid
quarterly,  of  0.25% of  the Class  B shares'  average daily  net assets  on an
annualized basis. The distributor expects to  reallocate most of its fee to  its
investment  representatives. The Distributor may, in its discretion, voluntarily
waive from time to time all or any  portion of its distribution fee and each  of
the  Distributor and the Adviser is free  to make additional payments out of its
own assets  to  promote  the  sale  of  Fund  shares,  including  payments  that
compensate  financial  institutions  for  distribution  services  or shareholder
services.
 
    Each Plan is designed to compensate the Distributor for its services, not to
reimburse the Distributor for its expenses,  and the Distributor may retain  any
portion  of the fee that it does not expend in fulfillment of its obligations to
the Fund.
 
    EXPENSES.  Each Portfolio is responsible  for payment of certain other  fees
and  expenses  (including  legal  fees, accountant's  fees,  custodial  fees and
printing and mailing  costs) specified  in the  Administration and  Distribution
Agreements.
 
                               PURCHASE OF SHARES
 
    Class  A shares  of each  Portfolio and  Class B  shares of  each Multiclass
Portfolio may be purchased, without sales commission, at the net asset value per
share next determined after receipt of the purchase order by the Portfolio.  See
"Valuation of Shares."
 
                                       39
<PAGE>
MINIMUM INVESTMENT AND ACCOUNT SIZES; CONVERSION FROM CLASS A TO CLASS B SHARES
 
    For  a Multiclass Portfolio  account opened on  or after January  2, 1996 (a
"New Multiclass Account"),  the minimum initial  investment and minimum  account
size  are $500,000 for Class A shares of each Portfolio and $100,000 for Class B
shares of  each  Multiclass Portfolio.  The  International Equity  Portfolio  is
currently  closed to new investors, with the exception of certain Morgan Stanley
customers.  The  minimum  initial   investment  for  Class   A  shares  of   the
International  Small Cap  Portfolio is  $500,000. Managed  Accounts may purchase
Class A  shares without  being subject  to such  minimum initial  investment  or
minimum  account  size requirements  for a  Portfolio  account. Officers  of the
Adviser and its affiliates are subject to the minimums for a Portfolio  account,
except  they may purchase Class B shares subject to a minimum initial investment
and minimum account size of $5,000 for a Multiclass Portfolio account.
 
    If the value  of a New  Multiclass Account containing  Class A shares  falls
below  $500,000  (but  remains  at or  above  $100,000)  because  of shareholder
redemption(s), the Fund will notify the  shareholders, and if the account  value
remains  below  $500,000 (but  remains at  or above  $100,000) for  a continuous
60-day period, the Class A shares in such account will convert to Class B shares
and will be subject to the distribution fee and other features applicable to the
Class B shares. The Fund,  however, will not convert Class  A shares to Class  B
shares  based solely upon changes in the  market that reduce the net asset value
of shares. Under current  tax law, conversions between  share classes are not  a
taxable event to the shareholder.
 
    Shares  in  a  Portfolio  account  opened  prior  to  January  2,  1996 were
designated Class A shares on January  2, 1996. Shares in a Multiclass  Portfolio
account  opened prior to January 2, 1996 (each, a "Pre-1996 Multiclass Account")
with a value  of $100,000 or  more on March  1, 1996 (a  "Grandfathered Class  A
Account")  remained Class A shares regardless of account size thereafter. Except
for shares in a Managed Account, shares in a Pre-1996 Multiclass Account with  a
value of less than $100,000 on March 1, 1996 (a "Grandfathered Class B Account")
converted to Class B shares on March 1, 1996. Grandfathered Class A Accounts and
Managed  Accounts are not subject  to conversion from Class  A shares to Class B
shares.
 
    Investors may also invest in the  Fund by purchasing shares through a  trust
department, broker, dealer, agent, financial planner, financial services firm or
investment  adviser.  An  investor  may  be  charged  an  additional  service or
transaction fee by that institution. The minimum investment levels may be waived
at the discretion  of the  Adviser for (i)  certain employees  and customers  of
Morgan  Stanley  or  its  affiliates  and  certain  trust  departments, brokers,
dealers, agents,  financial planners,  financial services  firms, or  investment
advisers  that  have  entered  into  an agreement  with  Morgan  Stanley  or its
affiliates; and (ii) retirement and deferred compensation plans and trusts  used
to  fund such  plans, including,  but not limited  to, those  defined in Section
401(a), 403(b) or  457 of the  Internal Revenue  Code of 1986,  as amended,  and
"rabbi  trusts."  The  Fund  reserves  the  right  to  modify  or  terminate the
conversion features of  the shares  as stated above  at any  time upon  60-days'
notice to shareholders.
 
MINIMUM ACCOUNT SIZES AND INVOLUNTARY REDEMPTION OF SHARES
 
    If  the value of  a New Multiclass  Account falls below  $100,000 because of
shareholder redemptions(s), the  Fund will  notify the shareholder,  and if  the
account  value remains below $100,000 for a continuous 60-day period, the shares
in such account are subject to redemption by the Fund and, if redeemed, the  net
asset  value of such shares will be  promptly paid to the shareholder. The Fund,
however, will not  redeem shares based  solely upon changes  in the market  that
reduce the net asset value of shares.
 
                                       40
<PAGE>
    For  purposes of redemptions by the Fund, the foregoing minimum account size
requirements do not apply to New  Multiclass Accounts containing Class B  shares
held by officers of the Adviser or its affiliates. However, if the value of such
account  held by an officer of the  Adviser or its affiliates falls below $5,000
because of shareholder redemption(s), the Fund will notify the shareholder,  and
if  the account value remains  below $5,000 for a  continuous 60-day period, the
shares in such account are subject to  redemption by the Fund and, if  redeemed,
the net asset value of such shares will be promptly paid to the shareholder.
 
    Grandfathered  Class A Accounts, Grandfathered  Class B Accounts and Managed
Accounts are not subject to involuntary redemption.
 
    If a  shareholder reduces  its total  investment in  Class A  shares of  the
International  Small Cap Portfolio to less  than $500,000, the investment may be
subject to redemption.
 
    The  Fund  reserves  the  right  to  modify  or  terminate  the  involuntary
redemption  features of  the shares  as stated above  at any  time upon 60-days'
notice to shareholders.
 
CONVERSION FROM CLASS B TO CLASS A SHARES
 
    If the value of Class B shares in a Multiclass Portfolio account  increases,
whether  due to shareholder  share purchases or market  activity, to $500,000 or
more, the Class B shares will convert to Class A shares. Under current tax  law,
such  conversion  is not  a taxable  event  to the  shareholder. Class  A shares
converted from  Class B  shares are  subject to  the same  minimum account  size
requirements  that are applicable to New  Multiclass Accounts containing Class A
shares, as stated above. The Fund reserves the right to modify or terminate this
conversion feature at any time upon 60-days' notice to shareholders.
 
INITIAL PURCHASES DIRECTLY FROM THE FUND
 
    The Fund's determination of an investor's eligibility to purchase shares  of
a  given class will  take precedence over  the investor's selection  of a class.
Assuming the investor is eligible for the  class, the Fund will select the  most
favorable class for the investor, if the investor has not done so.
 
1) BY  CHECK.   An account may  be opened  by completing and  signing an Account
   Registration Form and mailing it, together with a check ($500,000 minimum for
   Class A shares of each Portfolio and  $100,000 minimum for Class B shares  of
   each  Multiclass  Portfolio,  with  certain  exceptions  for  Morgan  Stanley
   employees and  select customers)  payable  to "Morgan  Stanley  Institutional
   Fund, Inc. -- [portfolio name]", to:
 
      Morgan Stanley Institutional Fund, Inc.
      P.O. Box 2798
      Boston, Massachusetts 02208-2798
 
 Payment  will be accepted only in  United States dollars, unless prior approval
 for payment in other currencies  is given by the  Fund. The Portfolio(s) to  be
 purchased  should be designated on the Account Registration Form. For purchases
 by check,  the  Fund is  ordinarily  credited  with Federal  Funds  within  one
 business  day. Thus your purchase of shares  by check is ordinarily credited to
 your account  at  the net  asset  value per  share  of the  relevant  Portfolio
 determined on the next business day after receipt.
 
                                       41
<PAGE>
2) BY  FEDERAL  FUNDS WIRE.   Purchases  may be  made by  having your  bank wire
   Federal Funds to the Fund's bank  account. In order to ensure prompt  receipt
   of your Federal Funds Wire, it is important that you follow these steps:
 
A.   Telephone  the Fund  (toll free: 1-800-548-7786)  and provide  us with your
    name, address,  telephone  number,  Social Security  or  Tax  Identification
    Number,  the  portfolio(s) selected,  the class  selected, the  amount being
    wired, and by  which bank.  We will  then provide  you with  a Fund  account
    number.  (Investors with existing accounts should also notify the Fund prior
    to wiring funds.)
 
B.   Instruct  your  bank to  wire  the  specified amount  to  the  Fund's  Wire
    Concentration  Bank Account (be sure  to have your bank  include the name of
    the portfolio(s)  selected,  the  class selected,  and  the  account  number
    assigned to you) as follows:
 
    Chase Manhattan Bank, N.A.
    One Manhattan Plaza
    New York, NY 10081-1000
    ABA #021000021
    DDA #910-2-733293
    Attn: Morgan Stanley Institutional Fund, Inc.
    Ref: (Portfolio name, your account number, your account name)
 
    Please call the Funds at 1-800-548-7786 prior to wiring funds.
 
C.   Complete and sign the Account Registration  Form and mail it to the address
    shown thereon.
 
  Purchase orders for shares of the  Portfolios which are received prior to  the
  regular  close of the NYSE (currently 4:00 p.m. Eastern Time) will be executed
  at the price computed  on the date  of receipt as long  as the Transfer  Agent
  receives  payment by check or  in Federal Funds prior  to the regular close of
  the NYSE on such day.
 
  Federal Funds purchase orders will be accepted only on a day on which the Fund
  and Chase (the "Custodian Bank") are open for business. Your bank may charge a
  service fee for wiring Federal Funds.
 
3) BY BANK WIRE.   The  same procedure outlined  under "By  Federal Funds  Wire"
   above  must be  followed in  purchasing shares  by bank  wire. However, money
   transferred by bank wire may or may  not be converted into Federal Funds  the
   same  day, depending on the time the  money is received and the bank handling
   the wire. Prior to such conversion, an investor's money will not be  invested
   and, therefore, will not be earning dividends. Your bank may charge a service
   fee for wiring funds.
 
ADDITIONAL INVESTMENTS
 
    You  may  add to  your account  at any  time (minimum  additional investment
$1,000 for each portfolio,  except for automatic  reinvestment of dividends  and
capital  gains  distributions for  which there  are  no minimums)  by purchasing
shares at net asset  value by mailing  a check to the  Fund (payable to  "Morgan
Stanley  Institutional Fund  -- [portfolio  name]") at  the above  address or by
wiring monies to the Custodian Bank as outlined above. It is very important that
your account name, the portfolio name and the class selected be specified in the
letter or wire to assure  proper crediting to your  account. In order to  ensure
that your wire orders are invested promptly,
 
                                       42
<PAGE>
you  are  requested  to  notify one  of  the  Fund's  representatives (toll-free
1-800-548-7786) prior to the wire  date. Additional investments will be  applied
to  purchase additional  shares in  the same  class held  by a  shareholder in a
Portfolio account.
 
OTHER PURCHASE INFORMATION
 
    The purchase price of the  Class A and Class B  shares of each Portfolio  is
the  net asset value next determined after the order is received. See "Valuation
of Shares." An order received prior to  the regular close of the New York  Stock
Exchange  ("NYSE"), which is currently 4:00  p.m. Eastern Time, will be executed
at the  price computed  on the  date of  receipt; an  order received  after  the
regular close of the NYSE will be executed at the price computed on the next day
the  NYSE is open as long as the  Transfer Agent receives payment by check or in
Federal Funds prior to the regular close of the NYSE on such day.
 
    Although the legal rights of Class A  and Class B shares will be  identical,
the  different expenses borne by  each class will result  in different net asset
values and dividends. The net  asset value of Class  B shares will generally  be
lower than the net asset value of Class A shares as a result of the distribution
expense  charged to Class B shares. It  is expected, however, that the net asset
value per share of the two classes  will tend to converge immediately after  the
recording  of dividends  which will  differ by  approximately the  amount of the
distribution expense accrual differential between the classes.
 
    In the interest  of economy and  convenience, and because  of the  operating
procedures  of the  Fund, certificates  representing shares  of the Portfolio(s)
will not be issued. All  shares purchased are confirmed  to you and credited  to
your  account on the Fund's  books maintained by the  Adviser or its agents. You
will have  the same  rights and  ownership with  respect to  such shares  as  if
certificates had been issued.
 
    To  ensure that checks are collected by the Fund, withdrawals of investments
made by check  are not presently  permitted until payment  for the purchase  has
been  received  which may  take  up to  eight business  days  after the  date of
purchase. As a condition  of this offering,  if a purchase  is cancelled due  to
nonpayment or because your check does not clear, you will be responsible for any
loss  the Fund or its  agents incur. If you are  already a shareholder, the Fund
may redeem shares from your account(s) to  reimburse the Fund or its agents  for
any  loss. In addition, you  may be prohibited or  restricted from making future
investments in the Fund.
 
    Investors may  also invest  in the  Fund by  purchasing shares  through  the
Distributor.
 
EXCESSIVE TRADING
 
    Frequent   trades  involving  either  substantial   portfolio  assets  or  a
substantial portion of your  account or accounts controlled  by you can  disrupt
management  of a portfolio and raise its expenses. Consequently, in the interest
of all the stockholders of the  Portfolios and the Portfolios' performance,  the
Fund  may in its discretion bar a  stockholder that engages in excessive trading
of shares of any class  of a portfolio from further  purchases of shares of  the
Fund  for an indefinite period. The Fund  considers excessive trading to be more
than one purchase and sale involving shares of the same class of a portfolio  of
the  Fund  within  any  120-day  period. As  an  example,  exchanging  shares of
portfolios of the Fund as follows amounts to excessive trading: exchanging Class
A shares of Portfolio A for Class A shares of Portfolio B, then exchanging Class
A shares of Portfolio B for Class  A shares of Portfolio C and again  exchanging
Class A shares of Portfolio C for Class A shares of Portfolio B within a 120-day
 
                                       43
<PAGE>
period.  Two  types  of transactions  are  exempt from  these  excessive trading
restrictions: (1) trades  exclusively between money  market portfolios; and  (2)
trades  done  in  connection  with  an asset  allocation  service,  such  as TFM
Accounts, managed or advised by MSAM and/or any of its affiliates.
 
                              REDEMPTION OF SHARES
 
    You may  withdraw all  or  any portion  of the  amount  in your  account  by
redeeming  shares at any time. Please note  that purchases made by check are not
permitted to be redeemed until payment of the purchase has been collected, which
may take up to eight business days after purchase. The Fund will redeem Class  A
shares  of each Portfolio or Class B  shares of each Multiclass Portfolio at the
next determined net asset value of shares of the applicable class. On days  that
both the NYSE and the Custodian Bank are open for business, the net asset values
per  share of  each of  the Portfolios  are determined  at the  regular close of
trading of the NYSE (currently 4:00 p.m. Eastern Time). Shares of each Portfolio
may be redeemed by mail or telephone. No charge is made for redemptions,  except
for  the imposition  of the 1%  transaction fee described  under "Fund Expenses"
above, which may  be assessed in  connection with redemptions  of shares of  the
International  Small Cap Portfolio. Any redemption  proceeds may be more or less
than the purchase price  of your shares depending  on, among other factors,  the
market value of the investment securities held by a Portfolio.
 
BY MAIL
 
    Each  Portfolio will redeem its  Class A or Class B  shares at the net asset
value determined on the date the request is received, if the request is received
in "good order" before  the regular close  of the NYSE.  Your request should  be
addressed  to Morgan  Stanley Institutional Fund,  Inc., P.O.  Box 2798, Boston,
Massachusetts 02208-2798, except that deliveries by overnight courier should  be
addressed  to Morgan  Stanley Institutional Fund,  Inc., c/o  Chase Global Funds
Services Company, 73 Tremont Street, Boston, Massachusetts 02108-3913.
 
    "Good order"  means that  the  request to  redeem  shares must  include  the
following documentation:
 
        (a)   A letter of instruction or a stock assignment specifying the class
    and number  of  shares  or dollar  amount  to  be redeemed,  signed  by  all
    registered  owners  of the  shares  in the  exact  names in  which  they are
    registered;
 
        (b)  Any  required   signature  guarantees   (see  "Further   Redemption
    Information" below); and
 
        (c)    Other supporting  legal documents,  if required,  in the  case of
    estates, trusts,  guardianships, custodianships,  corporations, pension  and
    profit sharing plans and other organizations.
 
    Shareholders who are uncertain of requirements for redemption should consult
with a Morgan Stanley Institutional Fund representative.
 
BY TELEPHONE
 
    Provided  you have previously elected the Telephone Redemption Option on the
Account Registration  Form, you  can  request a  redemption  of your  shares  by
calling  the Fund  and requesting  the redemption proceeds  be mailed  to you or
wired to your bank.  Please contact one of  Morgan Stanley Institutional  Fund's
representatives  for further details. In times of drastic market conditions, the
telephone redemption option  may be  difficult to implement.  If you  experience
difficulty in making a telephone redemption, your request may be made by regular
mail  or express  mail and it  will be implemented  at the net  asset value next
determined after it is received.
 
                                       44
<PAGE>
Redemption requests sent to the Fund through express mail must be mailed to  the
address  of the  Dividend Disbursing  and Transfer  Agent listed  under "General
Information". The Fund and the Fund's transfer agent (the "Transfer Agent") will
employ reasonable procedures  to confirm that  the instructions communicated  by
telephone are genuine. Redemption requests sent to the Fund through express mail
must  be mailed  to the  address of the  Dividend Disbursing  and Transfer Agent
listed under  "General  Information".  These procedures  include  requiring  the
investor  to provide certain personal identification  information at the time an
account  is  opened  and  prior  to  effecting  each  transaction  requested  by
telephone.  In addition, all telephone transaction requests will be recorded and
investors may be required to provide additional telecopied written  instructions
regarding  transaction requests. Neither the Fund nor the Transfer Agent will be
responsible for any loss, liability, cost or expense for following  instructions
received by telephone that either of them reasonably believes to be genuine.
 
    To  change the commercial  bank or account  designated to receive redemption
proceeds, a written  request must  be sent  to the  Fund at  the address  above.
Requests  to change the bank  or account must be  signed by each shareholder and
each signature must be guaranteed.
 
FURTHER REDEMPTION INFORMATION
 
    Normally the  Fund will  make payment  for all  shares redeemed  within  one
business  day of receipt  of the request, but  in no event  will payment be made
more than  seven days  after receipt  of  a redemption  request in  good  order.
However,  payments to investors  redeeming shares which  were purchased by check
will not be made until  payment for the purchase  has been collected, which  may
take up to eight days after the date of purchase. The Fund may suspend the right
of  redemption or postpone the date upon which redemptions are effected at times
when the NYSE is closed, or  under any emergency circumstances as determined  by
the Securities and Exchange Commission (the "Commission").
 
    If  the Board of  Directors determines that  it would be  detrimental to the
best interests of  the remaining  shareholders of  a Portfolio  to make  payment
wholly  or partly in cash, the Fund may  pay the redemption proceeds in whole or
in part by a distribution in-kind of  securities held by a Portfolio in lieu  of
cash    in    conformity   with    applicable    rules   of    the   Commission.
Distributions-in-kind will be made  in readily marketable securities.  Investors
may  incur brokerage charges on the sale  of portfolio securities so received in
payment of redemptions.
 
    To protect  your account,  the Fund  and its  agents from  fraud,  signature
guarantees  are required for  certain redemptions to verify  the identity of the
person who has  authorized a redemption  from your account.  Please contact  the
Fund  for further  information. See "Redemption  of Shares" in  the Statement of
Additional Information.
 
                              SHAREHOLDER SERVICES
 
EXCHANGE FEATURES
 
    You may exchange  shares that you  own in  any Portfolio for  shares of  any
other  available portfolio(s) of  the Fund (other  than the International Equity
Portfolio, which is  closed to  new investors). In  exchanging for  shares of  a
portfolio  with more  than one  class, the  class of  shares you  receive in the
exchange will be determined in the same  manner as any other purchase of  shares
and  will not  be based  on the  class of  shares surrendered  for the exchange.
Consequently, the same minimum initial  investment and minimum account size  for
determining  the  class  of shares  received  in  the exchange  will  apply. See
"Purchase of  Shares." Shares  of the  portfolios may  be exchanged  by mail  or
telephone.  The privilege to exchange shares  by telephone is automatic and made
available
 
                                       45
<PAGE>
without shareholder election. Before you make  an exchange, you should read  the
prospectus  of the portfolio(s) in which you seek to invest. Because an exchange
transaction is treated as a redemption followed by a purchase, an exchange would
be considered a  taxable event  for shareholders  subject to  tax. The  exchange
privilege  is only available with respect  to portfolios that are registered for
sale in  a shareholder's  state  of residence.  The  exchange privilege  may  be
modified  or  terminated  by  the  Fund at  any  time  upon  60-days'  notice to
shareholders.
 
BY MAIL
 
    In order to  exchange shares  by mail, you  should include  in the  exchange
request  the name, class of shares and account number of your current Portfolio,
the name(s) of the portfolio(s) and class(es) of shares into which you intend to
exchange shares, and the signatures of all registered account holders. Send  the
exchange  request to  Morgan Stanley  Institutional Fund,  Inc., P.O.  Box 2798,
Boston, Massachusetts 02208-2798.
 
BY TELEPHONE
 
    When exchanging shares by  telephone, have ready the  name, class of  shares
and  account number of your current Portfolio, the name(s) of the portfolio into
which you intend  to exchange shares,  your Social Security  number or Tax  I.D.
number,  and  your account  address. Requests  for telephone  exchanges received
prior to 4:00 p.m. (Eastern  Time) are processed at  the close of business  that
same  day  based on  the  net asset  value of  the  class(es) of  the portfolios
involved in the exchange of shares  at the close of business. Requests  received
after  4:00 p.m. (Eastern Time) are processed the next business day based on the
net asset value determined at the close of business on such day. For  additional
information   regarding  responsibility  for   the  authenticity  of  telephoned
instructions, see "Redemption of Shares -- By Telephone" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer  the registration  of any of  your Fund  shares to  another
person  by writing  to Morgan Stanley  Institutional Fund, Inc.,  P.O. Box 2798,
Boston, Massachusetts 02208-2798.  As in  the case of  redemptions, the  written
request  must  be  received in  good  order  before any  transfer  can  be made.
Transferring the  registration of  shares  may affect  the eligibility  of  your
account  for a given class  of the Portfolio's shares  may result in involuntary
conversion or redemption of your shares. See "Purchase of Shares" above.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of each of the Portfolios
is determined by dividing the total market value of the Portfolio's  investments
and  other assets attributable to such  class, less any liabilities attributable
to such class, by the  total number of outstanding shares  of each class of  the
Portfolio.  Net  asset value  is  calculated separately  for  each class  of the
Portfolios. Net asset value per share is  determined as of the regular close  of
the  NYSE on each day  that the NYSE is open  for business. Price information on
listed securities is  taken from the  exchange where the  security is  primarily
traded.  Securities  listed  on  a U.S.  securities  exchange  for  which market
quotations are available are valued at the last quoted sale price on the day the
valuation is made. Securities listed on  a foreign exchange are valued at  their
closing  price.  Unlisted securities  and listed  securities  not traded  on the
valuation date for which market quotations are not readily available are  valued
at  a price within a  range not exceeding the current  asked price nor less than
the current bid price. The current bid and asked prices are determined based  on
the  average bid  and asked  prices quoted on  such valuation  date by reputable
brokers.
 
                                       46
<PAGE>
    Bonds and other fixed income securities are valued according to the broadest
and most representative  market, which will  ordinarily be the  over-the-counter
market.  Net asset value includes interest  on fixed income securities, which is
accrued daily.  In addition,  bonds and  other fixed  income securities  may  be
valued on the basis of prices provided by a pricing service when such prices are
believed  to  reflect  the fair  market  value  of such  securities.  The prices
provided by a pricing service are determined without regard to bid or last  sale
prices  but take  into account institutional  size trading in  similar groups of
securities and any developments related  to the specific securities.  Securities
not  priced in this manner are valued at the most recently quoted bid price, or,
when securities exchange valuations are used, at the latest quoted sale price on
the day of valuation. If there is  no such reported sale, the latest quoted  bid
price will be used. Securities purchased with remaining maturities of 60 days or
less are valued at amortized cost, if it approximates market value. In the event
that  amortized  cost  does  not  approximate  market  value,  market  prices as
determined above will be used.
 
    The value of other assets and securities for which no quotations are readily
available (including  restricted  and  unlisted foreign  securities)  and  those
securities  for which it is inappropriate  to determine the prices in accordance
with the above-stated  procedures are  determined in  good faith  at fair  value
using  methods determined by the Board of Directors. For purposes of calculating
net asset value  per share, all  assets and liabilities  initially expressed  in
foreign  currencies will be translated into U.S.  dollars at the mean of the bid
price and asked price for such currencies against the U.S. dollar last quoted by
any major bank.
 
    Although the legal rights of Class A  and Class B shares will be  identical,
the  different expenses borne by  each class will result  in different net asset
values and dividends for the class.  Dividends will differ by approximately  the
amount  of the distribution expense accrual  differential among the classes. The
net asset value of  Class B shares  will generally be lower  than the net  asset
value  of the Class A shares as a result of the distribution expenses charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time  advertise the "total return" for each  class
of  a Portfolio.  THESE FIGURES  ARE BASED  ON HISTORICAL  EARNINGS AND  ARE NOT
INTENDED TO INDICATE FUTURE PERFORMANCE.
 
    Each of the  Portfolios may  advertise "total  return" which  shows what  an
investment  in a class of a Portfolio  would have earned over a specified period
of time (such as  one, five or  ten years) assuming  that all distributions  and
dividends by the Portfolio were reinvested in the same class on the reinvestment
dates  during the period. Total return does not take into account any federal or
state income taxes  that may  be payable on  dividends and  distributions or  on
redemption.  The Fund  may also  include comparative  performance information in
advertising or  marketing the  Portfolios' shares,  including data  from  Lipper
Analytical  Services, Inc.,  other industry  publications, business periodicals,
rating services and market indices.
 
    The performance figures  for Class  B shares  will generally  be lower  than
those  for Class  A shares because  of the  distribution fee charged  to Class B
shares.
 
                                       47
<PAGE>
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains  distributions for a class of  shares
will automatically be reinvested in additional shares at net asset value, except
that,  upon written notice to the Fund or by checking off the appropriate box in
the Distribution Option Section on the Account Registration Form, a  shareholder
may elect to receive income dividends and capital gains distributions in cash.
 
    Each Portfolio expects to distribute substantially all of its net investment
income  in  the form  of annual  dividends.  Net realized  gains, if  any, after
reduction for  any available  tax loss  carryforwards will  also be  distributed
annually.  Confirmations of the purchase of  shares of the Portfolio through the
automatic reinvestment of income dividends and capital gains distributions  will
be  provided, pursuant  to Rule 10b-10(b)  under the Securities  Exchange Act of
1934, as amended, on the next  monthly client statement following such  purchase
of  shares. Consequently, confirmation of such purchases will not be provided at
the time of completion of such purchases as might otherwise be required by  Rule
10b-10. Net capital gains, if any, will be distributed annually.
 
    Undistributed  net investment income is included in a Portfolio's net assets
for the purpose  of calculating  net asset value  per share.  Therefore, on  the
"ex-dividend"  date, the net asset value  per share excludes the dividend (i.e.,
is reduced by  the per  share amount of  the dividend).  Dividends paid  shortly
after  the purchase  of shares by  an investor,  although in effect  a return of
capital, are taxable to shareholders subject to income tax.
 
    Because of  the  distribution  fee  and  any  other  expenses  that  may  be
attributable  to the  Class B  shares, the  net income  attributable to  and the
dividends payable  on  Class  B  shares  will  be  lower  than  the  net  income
attributable  to and the dividends  payable on Class A  shares. As a result, the
net asset value per share of the classes of the Portfolios will differ at times.
Expenses of the  Portfolios allocated to  a particular class  of shares  thereof
will be borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No  attempt has been made to present  a detailed explanation of the federal,
state, or local income  tax treatment of the  Portfolios or their  shareholders.
Accordingly,  shareholders  are urged  to consult  their tax  advisers regarding
specific questions as to federal, state and local income taxes.
 
    Each Portfolio  is treated  as  a separate  entity  for federal  income  tax
purposes  and is not  combined with the Fund's  other Portfolios. Each Portfolio
intends to qualify for the  special tax treatment afforded regulated  investment
companies  under Subchapter M of  the Internal Revenue Code  of 1986, as amended
(the "Code"), so that the  Portfolio will be relieved  of federal income tax  on
that  part of its net investment income and net capital gain that is distributed
to shareholders.
 
    Each Portfolio distributes  substantially all of  its net investment  income
(including,  for  this purpose,  net short-term  capital gain)  to shareholders.
Dividends from a Portfolio's net  investment income are taxable to  shareholders
as  ordinary  income, whether  received in  cash or  in additional  shares. Such
dividends  paid   by  a   Portfolio   will  generally   qualify  for   the   70%
dividends-received  deduction for corporate  shareholders only to  the extent of
the aggregate qualifying  dividend income  received by the  Portfolio from  U.S.
corporations. Each Portfolio will report annually to its shareholders the amount
of dividend income qualifying for such treatment.
 
                                       48
<PAGE>
    Distributions  of net capital gain (the excess of net long-term capital gain
over net  short-term capital  loss)  are taxable  to shareholders  as  long-term
capital  gain, regardless of how long  shareholders have held their shares. Each
Portfolio sends reports annually to its  shareholders of the federal income  tax
status of all distributions made during the preceding year.
 
    Each   Portfolio  intends   to  make  sufficient   distributions  or  deemed
distributions of its ordinary income and capital gain net income (the excess  of
short-term  and long-term  capital gains  over short-term  and long-term capital
losses), including any available capital loss carryforwards, prior to the end of
each calendar year to avoid liability for federal excise tax.
 
    Dividends and  other  distributions  declared by  a  Portfolio  in  October,
November or December of any year and payable to shareholders of record on a date
in  such month will be deemed to have been paid by the Portfolio and received by
the shareholders in that year if the distributions are paid by the Portfolio  at
any time during the following January.
 
    The  sale, exchange or  redemption of shares  may result in  taxable gain or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the sale, exchange or redemption proceeds exceeds or is
less than the Shareholder's  adjusted basis in the  sold, exchanged or  redeemed
shares. If capital gain distributions have been made with respect to shares that
are  sold at a loss  after being held for  six months or less,  then the loss is
treated as  a  long-term  capital  loss  to  the  extent  of  the  capital  gain
distributions.
    The  conversion of Class A shares to Class  B shares should not be a taxable
event to the shareholder.
 
    Shareholders are urged  to consult  with their tax  advisors concerning  the
application of state and local income taxes to investments in a Portfolio, which
may differ from the federal income tax consequences described above.
 
    Investment  income  received  by  a Portfolio  from  sources  within foreign
countries may be subject to foreign income taxes withheld at the source. To  the
extent  that a Portfolio  is liable for  foreign income taxes  so withheld, each
Portfolio intends to operate so as to meet the requirements of the Code to  pass
through  to the shareholders credit for foreign income taxes paid. Although each
Portfolio intends to  meet Code  requirements to  pass through  credit for  such
taxes, there can be no assurance that each Portfolio will be able to do so.
 
    THE   TAX  DISCUSSION  SET  FORTH  ABOVE  IS  INCLUDED  HEREIN  FOR  GENERAL
INFORMATION ONLY. PROSPECTIVE  INVESTORS SHOULD CONSULT  THEIR OWN TAX  ADVISERS
WITH RESPECT TO THE TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN A PORTFOLIO.
 
                             PORTFOLIO TRANSACTIONS
 
    The  Investment  Advisory Agreement  authorizes  the Adviser  to  select the
brokers or  dealers that  will execute  the purchases  and sales  of  investment
securities  for each of the Fund's Portfolios and directs the Adviser to use its
best efforts to  obtain the best  available price and  most favorable  execution
with respect to all transactions for the Portfolios. The Fund has authorized the
Adviser to pay higher commissions in recognition of brokerage services which, in
the  opinion  of  the  Adviser,  are necessary  for  the  achievement  of better
execution, provided the Adviser believes this to be in the best interest of  the
Fund.
 
                                       49
<PAGE>
    Since shares of the Portfolios are not marketed through intermediary brokers
or  dealers, it is  not the Fund's  practice to allocate  brokerage or principal
business on the basis of sales of  shares which may be made through such  firms.
However,  the Adviser may  place portfolio orders  with qualified broker-dealers
who recommend the Portfolios or who act  as agents in the purchase of shares  of
the Portfolios for their clients.
 
    In  purchasing  and selling  securities for  a Portfolio,  it is  the Fund's
policy to seek to obtain quality execution at the most favorable prices, through
responsible  broker-dealers.  In   selecting  broker-dealers   to  execute   the
securities  transactions for the Portfolios, consideration will be given to such
factors as the price of the security,  the rate of the commission, the size  and
difficulty  of  the  order,  the  reliability,  integrity,  financial condition,
general execution and operational capabilities of competing broker-dealers,  and
the  brokerage  and  research services  which  they  provide to  the  Fund. Some
securities considered for investment by a Portfolio may also be appropriate  for
other  clients  served  by  the  Adviser.  If  purchase  or  sale  of securities
consistent with the investment policies of a Portfolio and one or more of  these
other  clients served by  the Adviser is  considered at or  about the same time,
transactions in such securities will be  allocated among the Portfolio and  such
other  clients in a manner  deemed fair and reasonable  by the Adviser. Although
there is  no specified  formula for  allocating such  transactions, the  various
allocation methods used by the Adviser, and the results of such allocations, are
subject to periodic review by the Fund's Board of Directors.
 
    Subject to the overriding objective of obtaining the best possible execution
of  orders, the Adviser may allocate a portion of the Fund's portfolio brokerage
transactions to Morgan Stanley or broker affiliates of Morgan Stanley. In  order
for  Morgan Stanley or  its affiliates to effect  any portfolio transactions for
the Portfolios, the commissions, fees  or other remuneration received by  Morgan
Stanley  or  such  affiliates  must  be  reasonable  and  fair  compared  to the
commissions, fees or other remuneration paid to other brokers in connection with
comparable transactions involving similar securities being purchased or sold  on
a securities exchange during a comparable period of time. Furthermore, the Board
of  Directors of the Fund,  including a majority of  those Directors who are not
"interested persons," as defined in the 1940 Act, have adopted procedures  which
are  reasonably  designed  to  provide  that  any  commissions,  fees  or  other
remuneration paid to Morgan Stanley or  such affiliates are consistent with  the
foregoing standard.
 
    Portfolio  securities will not be  purchased from or through,  or sold to or
through, the Adviser or Morgan Stanley  or any "affiliated persons," as  defined
in  the 1940 Act, of Morgan Stanley when such entities are acting as principals,
except to the extent permitted by law.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund  was organized  as a  Maryland corporation  on June  16, 1988.  The
Articles  of Incorporation, as amended and restated, permit the Fund to issue up
to 34 billion shares of common stock,  with $.001 par value per share.  Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number  of shares the  Fund is authorized  to issue without  the approval of the
shareholders of the  Fund. Subject  to the  notice period  to shareholders  with
respect  to shares held by shareholders, the Board of Directors has the power to
designate one or  more classes of  shares of  common stock and  to classify  and
reclassify any unissued shares with
 
                                       50
<PAGE>
respect  to  such classes.  The shares  of  common stock  of each  Portfolio are
currently classified  into two  classes, the  Class  A shares  and the  Class  B
shares, except for the International Small Cap, Money Market and Municipal Money
Market Portfolios, which only offer Class A shares.
 
    The   shares  of   each  Portfolio,  when   issued,  will   be  fully  paid,
nonassessable, fully transferable and  redeemable at the  option of the  holder.
The  shares have no preference as to conversion, exchange, dividends, retirement
or other features and have no  pre-emptive rights. The shares of each  Portfolio
have non-cumulative rights, which means that the holders of more than 50% of the
shares  voting for the election of Directors  can elect 100% of the Directors if
they choose  to do  so.  Persons or  organizations owning  25%  or more  of  the
outstanding  shares of a Portfolio  may be presumed to  "control" (as defined in
the 1940 Act) such Portfolio.  Under Maryland law, the  Fund is not required  to
hold  an annual meeting of  its shareholders unless required  to do so under the
1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its  shareholders annual and semi-annual reports;  the
financial  statements  appearing in  annual reports  are audited  by independent
accountants. Monthly unaudited portfolio  data is also  available from the  Fund
upon request.
 
    In  addition, the Adviser or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
CUSTODIAN
 
    As of September  1, 1995,  domestic securities and  cash are  held by  Chase
which  replaced U.S.  Trust as  the Fund's domestic  custodian. Chase  is not an
affiliate of  the Adviser  or  the Distributor.  Morgan Stanley  Trust  Company,
Brooklyn,  New York ("MSTC"),  an affiliate of the  Adviser and the Distributor,
acts as the Fund's custodian for  foreign assets held outside the United  States
and  employs subcustodians  approved by  the Board of  Directors of  the Fund in
accordance with regulations of  the Securities and  Exchange Commission for  the
purpose  of providing  custodial services  for such  assets. MSTC  may also hold
certain domestic assets for  the Fund. For more  information on the  custodians,
see "General Information -- Custody Arrangements" in the Statement of Additional
Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase   Global   Funds  Services   Company,   73  Tremont   Street,  Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse  LLP serves  as independent  accountants for  the Fund  and
audits its annual financial statements.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       51
<PAGE>
<TABLE>
<CAPTION>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
           GLOBAL EQUITY, INTERNATIONAL EQUITY, INTERNATIONAL SMALL CAP, 
           ASIAN EQUITY, EUROPEAN EQUITY, JAPANESE EQUITY 
           AND LATIN AMERICAN PORTFOLIOS
           P.O. BOX 2798, BOSTON, MA 02208-2798


- ---------------------------------------------------------------------------------------------------------------

                           ACCOUNT REGISTRATION FORM
- ---------------------------------------------------------------------------------------------------------------
<S>                        <C>
ACCOUNT INFORMATION        If you need assistance in filling out this form     
Fill in where applicable   for the Morgan Stanley Institutional Fund, please   
                           contact your Morgan Stanley representative or call  
                           us toll free 1-(800)-548-7786. Please print all     
                           items except signature, and mail to the Fund at the
                           address above.

- ---------------------------------------------------------------------------------------------------------------
A)  REGISTRATION
    1. INDIVIDUAL            1. / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / /
                                 First Name           Initial              Last Name
    2. JOINT TENANTS         2. / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / /
       (RIGHTS OF                First Name           Initial              Last Name
       SURVIVORSHIP            / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / /
       PRESUMED UNLESS           First Name           Initial              Last Name
       TENANCY IN COMMON 
       IS INDICATED)      
- ---------------------------------------------------------------------------------------------------------------
    3. CORPORATIONS,        3.  / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / /
       TRUSTS AND OTHERS       
       Please call the          / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / /
       Fund for additional
       documents that may       / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / /
       be required to set 
       up account and to 
       authorize transactions.
                                Type of / / INCORPORATED / / UNINCORPORATED / / PARTNERSHIP / / UNIFORM GIFT/TRANSFER TO MINOR 
                                Registration:                 ASSOCIATION                   (ONLY ONE CUSTODIAN AND MINOR PERMITTED)


                                / / TRUST __________________________________     / / OTHER (Specify) ______________________________
- ---------------------------------------------------------------------------------------------------------------
B)  MAILING ADDRESS         Street or P.O. Box / / / / / / / / / / / / / / / / / / / / / / / / / / / /

    Please fill in 
    completely, including   City / / / / / / / / / / / / / State / / / Zip / / / / / /-/ / / / / / / / 
    telephone number(s).
                            Home                                   Business
                            Telephone No./ / / /-/ / / /-/ / / / / Telephone No./ / / /-/ / / /-/ / / /
                            / / United States  / / Resident  / /Non-Resident Alien:
                                Citizen            Alien        Indicate Country of Residence _________
- ---------------------------------------------------------------------------------------------------------------
C)  TAXPAYER                PART 1. Enter your Taxpayer            IMPORTANT TAX INFORMATION 
    IDENTIFICATION          Identification Number. For most          You (as a payee) are required by
    NUMBER                  individual taxpayers, this is your     law to provide us (as payer) with
    If the account is in    Social Security Number.                your correct Taxpayer Identification
    more than one name,     TAXPAYER IDENTIFICATION NUMBER         Number. Accounts that have a missing
    CIRCLE THE NAME OF THE    / / / /-/ / / / / / / / /            or incorrect Taxpayer Identification
    PERSON WHOSE TAXPAYER               OR                         Number will be subject to backup
    IDENTIFICATION NUMBER       SOCIAL SECURITY NUMBER             withholding at a 31% rate on dividends,
    IS PROVIDED IN SECTION    / / / /-/ / /-/ / / / /              distributions and other payments.
    A) ABOVE. If no name      PART 2. BACKUP WITHHOLDING           If you have not provided us with
    is circled, the number    / / Check this box if you are        your correct taxpayer identification
    will be considered to be  NOT subject to Backup                number, you may be subject to 
    that of the last name     Withholding under the                a $50 penalty imposed by the Internal
    listed. For Custodian     provisions of Section                Revenue Service.
    account of a minor        3406(a)(1)(C) of the Internal          Backup withholding is not an
    (Uniform Gifts/Transfers  Revenue Code.                        additional tax; the tax liability of
    to Minors Acts), give the                                      persons subject to backup withholding
    Social Security Number                                         will be reduced by the amount of tax
    of the minor.                                                  withheld. If withholding results in
                                                                   an overpayment of taxes, a refund 
                                                                   may be obtained.
                                                                     You may be notified
                                                                   that you are subject to backup 
                                                                   withholding under Section 3406(a)(1)(C)
                                                                   of the Internal Revenue Code because you
                                                                   have underreported interest or dividends
                                                                   or you were required to but failed to
                                                                   file a return which would have included a
                                                                   reportable interest or dividend payment. IF
                                                                   YOU HAVE NOT BEEN SO NOTIFIED, CHECK THE
                                                                   BOX IN PART 2 AT LEFT.

- ---------------------------------------------------------------------------------------------------------------

D)  PORTFOLIO AND          For Purchase of the following Portfolio(s):     
    CLASS SECTION          GLOBAL EQUITY PORTFOLIO                     / / Class A Shares $____ / / Class B Shares $____
    (Class A shares        INTERNATIONAL SMALL CAP PORTFOLIO           / / Class A Shares $____
    minimum $500,000       EUROPEAN EQUITY PORTFOLIO                   / / Class A Shares $____ / / Class B Shares $____
    for each Portfolio     LATIN AMERICAN PORTFOLIO                    / / Class A Shares $____ / / Class B Shares $____
    and Class B shares     INTERNATIONAL EQUITY PORTFOLIO              / / Class A Shares $____ / / Class B Shares $____
    minimum $100,000 for   ASIAN EQUITY PORTFOLIO                      / / Class A Shares $____ / / Class B Shares $____
    the Global Equity,     JAPANESE EQUITY PORTFOLIO                   / / Class A Shares $____ / / Class B Shares $____
    International Equity,                                              Total Initial Investment $_____________
    Asian Equity,
    European Equity,
    Japenese Equity and
    Latin American Equity
    Portfolios). Please
    indicate Portfolio,
    class and amount.

<PAGE>
- ---------------------------------------------------------------------------------------------------------------


E)  METHOD OF   Payment by:
    INVESTMENT  / / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND, INC.--PORTFOLIO NAME)
     Please
    indicate
    portfolio,
    manner of   / / Exchange $____________ From________________ / / / / / / / / / / /-/ /
    payment.                                Name of Portfolio          Account No.

               / / Account previously established by: / / Phone exchange / / Wire on_____/ / / / / / / / / / / /-/ /
                                                                                    Date         Account No.   (Check
                                                                              (Previously assigned by the Fund) Digit)




- ---------------------------------------------------------------------------------------------------------------

F)  DISTRIBUTION                                       Income dividends and capital gains distributions (if any)  to
    OPTION                                             be reinvested in additional shares unless either box below is
                                                       checked.

                                                       / / Income dividends to be paid in cash, capital
                                                           gains distributions (if any) in shares.

                                                      / /  Income dividends and capital gains distributions
                                                           (if any) to be paid in cash.

- ---------------------------------------------------------------------------------------------------------------


G)  TELEPHONE REDEMPTION         / / I/we hereby authorize the Fund and its      ______________________    ________________
    AND EXCHANGE OPTION              agents to honor any telephone requests      Name of COMMERCIAL Bank   Bank Account No.
    Please select at time of         to wire redemption proceeds to the            (Not Savings Bank)
    initial application if you       commercial bank indicated at right and/or                             ________________
    wish to redeem or                mail redemption proceeds to the name and                                Bank ABA No.
    exchange shares by telephone.    address in which my/our fund account is
    A SIGNATURE GUARANTEE IS         registered if such requests are believed
    REQUIRED IF BANK ACCOUNT IS      to be authentic.                           _________________________________________________
    NOT REGISTERED IDENTICALLY
    TO YOUR FUND ACCOUNT.        THE FUND AND THE FUND'S TRANSFER AGENT WILL    Name(s) in which your BANK Account is Established
                                 EMPLOY REASONABLE PROCEDURES TO CONFIRM THAT
                                 INSTRUCTIONS COMMUNICATED BY TELEPHONE ARE     _________________________________________________
    TELEPHONE REQUESTS FOR       GENUINE. THESE PROCEDURES INCLUDE REQUIRING                 Bank's Street Address
    REDEMPTIONS OR EXCHANGE      THE INVESTOR TO PROVIDE CERTAIN PERSONAL
    WILL NOT BE HONORED UNLESS   IDENTIFICATION INFORMATION AT THE TIME AN      _________________________________________________
    THE BOX IS CHECKED.          ACCOUNT IS OPENED AND PRIOR TO EFFECTING EACH  City                    State                Zip
                                 TRANSACTION REQUESTED BY TELEPHONE. IN ADDITION,
                                 ALL TELEPHONE TRANSACTION REQUESTS WILL BE RECORDED
                                 AND INVESTORS MAY BE REQUIRED TO PROVIDE ADDITIONAL
                                 TELECOPIED WRITTEN INSTRUCTIONS OF TRANSACTION
                                 REQUESTS. NEITHER THE FUND NOR THE TRANSFER AGENT WILL
                                 BE RESPONSIBLE FOR ANY LOSS, LIABILITY, COST OR EXPENSE
                                 FOR FOLLOWING INSTRUCTIONS RECEIVED BY TELEPHONE THAT
                                 IT REASONABLY BELIEVES TO BE GENUINE.


- ---------------------------------------------------------------------------------------------------------------

H)  INTERESTED PARTY
    OPTION
    In addition to the account   _________________________________________________________________
    statement sent to my/our                                 Name
    registered address, I/we     _________________________________________________________________
    hereby authorize the fund    
    to mail duplicate            _________________________________________________________________
    statements to the name and                              Address
    address provided at right.
                                 _________________________________________________________________
                                  City                      State                     Zip Code

- ---------------------------------------------------------------------------------------------------------------

I)  DEALER 
    INFORMATION                  _______________________  _______________________________  ___________
                                 Representative Name          Representative No.             Branch No.

- ---------------------------------------------------------------------------------------------------------------

J)  SIGNATURE OF        The undersigned certify  that I/we  have full  authority and  legal
    ALL HOLDERS         capacity  to purchase and redeem shares of the Fund and affirm that I/we
    AND TAXPAYER        have received a current Prospectus  of the Morgan Stanley  Institutional
    CERTIFICATION       Fund,  Inc. and agree to  be bound by its  terms. UNDER THE PENALTIES OF
    Sign Here >         PERJURY, I/WE CERTIFY THAT THE INFORMATION PROVIDED IN SECTION C)
                        ABOVE IS TRUE, CORRECT AND COMPLETE.

                        (X)                                 (X)
                        __________________________________  ______________________________________
                        Signature                Date       Signature                  Date


- ---------------------------------------------------------------------------------------------------------------

</TABLE>

<PAGE>






                 (This page has been left blank intentionally.)

<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO  DEALER, SALES  REPRESENTATIVE OR ANY  OTHER PERSON HAS  BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE  CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS  HAVING BEEN AUTHORIZED BY THE FUND  OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF  THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION  TO
ANY  PERSON TO WHOM  IT IS UNLAWFUL TO  MAKE SUCH OFFER  OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<CAPTION>
                                                    PAGE
                                                    ----
<S>                                                 <C>
Fund Expenses.....................................    2
Financial Highlights..............................    6
Prospectus Summary................................   14
Investment Objectives and Policies................   18
Additional Investment Information.................   26
Investment Limitations............................   35
Management of the Fund............................   35
Purchase of Shares................................   39
Redemption of Shares..............................   44
Shareholder Services..............................   45
Valuation of Shares...............................   46
Performance Information...........................   47
Dividends and Capital Gains Distributions.........   48
Taxes.............................................   48
Portfolio Transactions............................   49
General Information...............................   50
Account Registration Form
</TABLE>
 
                            GLOBAL EQUITY PORTFOLIO
                         INTERNATIONAL EQUITY PORTFOLIO
                       INTERNATIONAL SMALL CAP PORTFOLIO
                             ASIAN EQUITY PORTFOLIO
                           EUROPEAN EQUITY PORTFOLIO
                           JAPANESE EQUITY PORTFOLIO
                            LATIN AMERICAN PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
 
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  Incorporated
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                      P.O. BOX 2798, BOSTON, MA 02208-2798
 
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