MORGAN STANLEY INSTITUTIONAL FUND INC
N-30B-2, 1997-12-12
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<TABLE>
<S>                                         <C>
DIRECTORS                                   OFFICERS
Barton M. Biggs                             James W. Grisham
CHAIRMAN OF THE BOARD                       VICE PRESIDENT
Chairman and Director, Morgan Stanley       Harold J. Schaaff,
Asset Management Inc. and Morgan Stanley    Jr.
Asset Management Limited; Managing          VICE PRESIDENT
Director, Morgan Stanley & Co.              Joseph P. Stadler
Incorporated                                VICE PRESIDENT
Michael F. Klein                            Valerie Y. Lewis
DIRECTOR AND PRESIDENT                      SECRETARY
Principal, Morgan Stanley Asset Management  Karl O. Hartmann
Inc. and Morgan Stanley & Co. Incorporated  ASSISTANT SECRETARY
John D. Barrett II                          Joanna M. Haigney
Chairman and Director,                      TREASURER
Barrett Associates, Inc.                    Rene J. Feuerman
Gerard E. Jones                             ASSISTANT TREASURER
Partner, Richards & O'Neil LLP
Andrew McNally IV
Chairman and Chief Executive Officer, Rand
McNally
Samuel T. Reeves
Chairman of the Board and Chief Executive
Officer,
Pinacle Trading L.L.C.
Fergus Reid
Chairman and Chief Executive Officer,
LumeLite Corporation
Frederick O. Robertshaw
Of Counsel, Copple, Chamberlin &
Boehm, P.C.
</TABLE>
 
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INVESTMENT ADVISER AND ADMINISTRATOR
Morgan Stanley Asset Management Inc.
1221 Avenue of the Americas
New York, New York 10020
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DISTRIBUTOR
Morgan Stanley & Co. Incorporated
1251 Avenue of the Americas
New York, New York 10020
           ---------------------------------------------------------
CUSTODIANS
The Chase Manhattan Bank
3 Chase MetroTech Center
Brooklyn, NY 11245
 
Morgan Stanley Trust Company
One Pierrepont Plaza
Brooklyn, New York 11210
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LEGAL COUNSEL
Morgan, Lewis & Bockius LLP
2000 One Logan Square
Philadelphia, Pennsylvania 19103
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INDEPENDENT ACCOUNTANTS
Price Waterhouse LLP
1177 Avenue of the Americas
New York, New York 10036
 
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For current performance, current net asset value, or for assistance with your
account, please contact the Fund at (800) 548-7786. This report is authorized
for distribution only when preceded or accompanied by prospectuses of the Morgan
Stanley Institutional Fund, Inc.
 
[LOGO] MORGAN STANLEY
       INSTITUTIONAL FUND, INC.
       P.O. Box 2798
       Boston, MA 02208-2798
 
[LOGO] MORGAN STANLEY
       INSTITUTIONAL FUND, INC.
 
                             FIXED INCOME PORTFOLIO
                              THIRD QUARTER REPORT
                               SEPTEMBER 30, 1997
<PAGE>
LETTER TO SHAREHOLDERS
- -------
 
The  Fixed Income Portfolio invests primarily in a diversified portfolio of U.S.
Government  securities,   corporate   bonds  (including   competitively   priced
Eurodollar bonds), mortgage-backed securities and other fixed income securities.
Targeted  rates of return for  the Portfolio are based  on current and projected
market and  economic  conditions and  on  a conservative  investment  management
approach.
 
For  the nine month and one year periods ended September 30, 1997, the Portfolio
had total returns of 6.62% and 9.92%, respectively, for Class A shares and 6.61%
and 9.79%,  respectively,  for Class  B  shares  compared to  6.52%  and  9.71%,
respectively,  for the Lehman  Aggregate Bond Index (the  "Index"). For the five
year period ended September 30, 1997, the average annual total return for  Class
A  shares was 7.00% compared  to 6.92% for the Index.  From inception on May 15,
1991   to   September    30,   1997,   the    average   annual   total    return
 
PERFORMANCE COMPARED TO THE LEHMAN AGGREGATE BOND INDEX(1)
- ----------------------------------------------------
 
<TABLE>
<CAPTION>
                                                  TOTAL RETURNS(2)
                                 --------------------------------------------------
                                                                         AVERAGE
                                                           AVERAGE       ANNUAL
                                                 ONE       ANNUAL         SINCE
                                     YTD        YEAR     FIVE YEARS     INCEPTION
                                    -----     ---------  -----------  -------------
<S>                              <C>          <C>        <C>          <C>
PORTFOLIO--CLASS A.............        6.62%       9.92%       7.00%         8.42%
PORTFOLIO--CLASS B.............        6.61        9.79         N/A          6.30
INDEX--CLASS A.................        6.52        9.71        6.92          8.38
INDEX--CLASS B.................        6.52        9.71         N/A          5.83
</TABLE>
 
1.  The  Lehman  Aggregate Bond  Index is  an unmanaged  index comprised  of the
    Government/Corporate Index,  the Mortgage-Backed  Securities Index  and  the
    Asset-Backed Securities Index.
 
2.  Total  returns for the Portfolio reflect  expenses waived and reimbursed, if
    applicable, by the  Adviser. Without  such waiver  and reimbursement,  total
    returns would be lower.
 
PAST PERFORMANCE IS NOT PREDICTIVE OF FUTURE PERFORMANCE.
 
- ------------------------------
 
THE  PERFORMANCE RESULTS PROVIDED ARE FOR INFORMATIONAL PURPOSES ONLY AND SHOULD
NOT BE CONSTRUED  AS A  GUARANTEE OF  THE PORTFOLIO'S  FUTURE PERFORMANCE.  PAST
PERFORMANCE SHOWN IS NOT PREDICTIVE OF FUTURE PERFORMANCE. INVESTMENT RETURN AND
PRINCIPAL  VALUE WILL FLUCTUATE SO THAT AN INVESTOR'S SHARES, WHEN REDEEMED, MAY
BE WORTH MORE OR LESS THAN THEIR ORIGINAL COST. YIELDS WILL FLUCTUATE AS  MARKET
CONDITIONS CHANGE.
 
for  Class A shares was 8.42% compared to 8.38% for the Index. From inception on
January 2, 1996 to September 30, 1997, the average annual total return for Class
B shares was 6.30% compared to 5.83% for the Index.
 
As of September 30, 1997, the Portfolio had an SEC 30-day yield of 6.24% for the
Class A shares and 6.10% for the Class B shares.
 
The fixed  income markets  produced another  quarter of  solid returns  as  bond
yields  ended the quarter roughly 40 basis points lower than where they started.
The   Lehman   Aggregate   Bond   Index   returned   3.32%   and   the    Lehman
Government/Corporate  Index returned 3.50% for  the third quarter. Combined with
strong performance during the  prior three months,  these returns represent  the
best  consecutive quarterly  returns for these  indices since the  first half of
1995. For the first nine months of  1997 the Aggregate Index returned 6.52%  and
the Government/Corporate Index was up 6.34%.
 
The  driving  force behind  these  favorable bond  market  returns has  been the
exceptional behavior of the major inflation measures. While economic growth  has
been   relatively   strong,  no   evidence  of   inflation  has   been  present.
Year-over-year changes in  the core  Consumer Price Index  continued at  30-year
lows,  while the  Producer Price Index  extended its string  of negative monthly
readings to seven,  before finally  registering a positive  change. The  Federal
Reserve  responded favorably to  this inflation environment  by holding monetary
policy steady  at  its  July,  August and  September  meetings.  While  the  Fed
continues  to  express  concerns  about  the pace  of  growth,  its  actions and
statements have reinforced  the view in  the marketplace that  the Fed will  not
tighten without a deterioration in inflation measures.
 
In  response to this stable Fed policy low inflation environment, interest rates
fell substantially over the quarter. There was, however, considerable volatility
on a month-to-month basis. Long bond yields fell almost 50 basis points in July,
before rising  30 basis  points  in August,  only to  fall  20 basis  points  in
September. In contrast to
 
                                       2
<PAGE>
several  recent periods  in which  strong economic  growth caused  rates to rise
sharply, signs of strong  growth in the  third quarter had  only a moderate  and
temporary  impact on rates. Long rates fell more than short rates over the third
quarter, with the yield curve flattening by roughly 10 basis points. Long  rates
have been more responsive to declining inflation expectations, while short rates
are limited by the 5.5% Federal Funds rate.
 
From a sector standpoint, the non-Treasury sectors turned in a mixed performance
versus  Treasuries. The  corporate market  provided a  marginal return advantage
over Treasuries during the  third quarter, but selected  portions of the  sector
performed  quite  poorly.  Spreads  in the  Yankee  sector  widened particularly
sharply over the quarter due to pressures in Southeast Asia. The mortgage-backed
sector also started to  exhibit signs of weakness  during the third quarter.  As
declining  interest  rates  raised  prepayment  concerns,  the  sector underper-
formed substantially  in  July.  Although  it  recovered  fully  in  August  and
September,  tight spreads  appear to  leave the  sector vulnerable  to a further
market rally.
 
As was the case in  the second quarter, foreign bond  markets turned in a  mixed
performance  relative to the U.S. bond market during the third quarter. With the
exception of  Italy and  the United  Kingdom, the  major European  bond  markets
lagged  the strong performance of  the U.S. On the  other hand, the Japanese and
Canadian bond markets outperformed  the U.S. bond market  by large amounts  over
the quarter.
 
We  maintained  a long  duration  position of  .3 to  .4  years relative  to our
benchmarks throughout the  third quarter.  As measured by  real interest  rates,
bond  market valuation has been attractive and  the interest rate trend has been
generally favorable.  We have  been underweighted  in the  prepayment  sensitive
segment  of the mortgage-backed market based on their rich historical valuations
and have limited  our mortgage pass-through  holdings to those  segments of  the
market  with  more  favorable  convexity characteristics  such  as  discount and
seasoned mortgages and seven year balloons. In addition, we continued to add  to
our  asset-backed holdings, where  we have been  able to add  securities with an
attractive combination of quality, yield spread  and convexity. We also added  a
small  position in GNMA adjustable rate  mortgages based on attractive valuation
characteristics. Our Portfolio  remains overweighted in  corporate bonds.  While
there were no major changes to our holdings from the prior quarter, we did add a
number  of  putable  corporate bonds  that  help  enhance the  convexity  of our
Portfolio. Finally, we eliminated our holdings in hedged German bonds during the
quarter, as  political  developments  related to  the  European  Monetary  Union
increased the risks of this position relative to the potential rewards.
 
We  begin  the  fourth  quarter  about .4  years  longer  in  duration  than our
benchmark. We  will likely  maintain  this duration  exposure until  either  the
falling  interest rate trend changes or market valuations become unfavorable. We
remain overweighted in  yield advantaged  sectors, primarily  the corporate  and
asset-backed  sectors. While we would not anticipate major changes to our sector
allocation at current valuation levels, spread volatility has increased of  late
and we are prepared to respond should spread pressures emerge. In particular, we
would  view  a further  rally  that resulted  in  wider mortgage  spreads  as an
opportunity to increase exposure to this sector.
 
Warren Ackerman, III
PORTFOLIO MANAGER
 
October 1997
 
                                       3
<PAGE>
INVESTMENTS (UNAUDITED)
- ----------
SEPTEMBER 30, 1997
<TABLE>
<CAPTION>
     FACE
    AMOUNT                                                VALUE
     (000)                                                (000)
- ---------------                                         ---------
<C>               <S>                                   <C>
FIXED INCOME SECURITIES (94.7%)
 U.S. GOVERNMENT AND AGENCY OBLIGATIONS (59.5%)
   U.S. TREASURY BONDS (3.2%)
$         5,000    6.25%, 8/15/23                       $  4,854
                                                        ---------
   U.S. TREASURY NOTES (40.3%)
          6,000    6.25%, 5/31/00                          6,054
         30,000    7.25%, 8/15/04                         31,894
         20,000    6.50%, 8/15/05                         20,425
          3,500    6.25%, 2/15/07                          3,518
                                                        ---------
                                                          61,891
                                                        ---------
   FEDERAL HOME LOAN MORTGAGE CORPORATION (1.3%)
              9    13.00%, 9/01/10                            10
          2,131    6.00%, 3/01/11                          2,089
                                                        ---------
                                                           2,099
                                                        ---------
   FEDERAL NATIONAL MORTGAGE ASSOCIATION (12.4%)
          4,089    6.00%, 9/01/10                          4,014
          5,202    6.00%, 2/01/11                          5,088
          1,533    6.00%, 5/01/11                          1,500
          8,666    6.50%, 4/01/24                          8,483
                                                        ---------
                                                          19,085
                                                        ---------
   GOVERNMENT NATIONAL MORTGAGE ASSOCIATION II ARM (2.3%)
          3,500    6.00%, 7/20/27                          3,531
                                                        ---------
  TOTAL U.S. GOVERNMENT AND AGENCY OBLIGATIONS            91,460
                                                        ---------
 FOREIGN GOVERNMENT AND AGENCY OBLIGATION (3.8%)
          6,000    Republic of Poland, `Euro',
                    (Floating Rate), 6.9375%,
                    10/27/24                               5,885
                                                        ---------
 CORPORATE BONDS AND NOTES (22.0%)
   BROADCAST-RADIO & TELEVISION (1.0%)
          1,500    News America Holdings, 7.75%,
                    12/01/45                               1,460
                                                        ---------
   FINANCE (21.0%)
          2,500    American General Institutional
                    Capital, Series A, 7.57%,
                    12/01/45                               2,450
          1,500    Banco Santiago, 7.00%, 7/18/07          1,503
 
<CAPTION>
     FACE
    AMOUNT                                                VALUE
     (000)                                                (000)
- ---------------                                         ---------
<C>               <S>                                   <C>
$         2,000    BankAmerica (144A), 7.70%,
                    12/31/26                            $  1,982
          2,500    BT Capital Trust, Series B1,
                    (144A), 7.90%, 1/15/27                 2,523
          2,250    EIBKOR Global Bond, 6.50%, 2/10/02      2,221
          2,000    First Chicago, 7.75%, 12/01/26          1,978
          2,500    General Motors Acceptance Corp.,
                    7.375%, 6/22/00                        2,571
          3,000    Goldman Sachs Group, 6.25%,
                    2/01/03                                2,964
          2,500    Hutchison Whampoa, Class B,
                    (144A), 7.45%, 8/01/17                 2,482
          1,300    Lehman Brothers Holdings, Inc.,
                    7.375%, 5/15/04                        1,341
          2,200    Lehman Brothers, Inc., 7.50%,
                    8/01/26                                2,322
          1,500    Liberty Mutual, 7.875%, 10/15/26        1,574
          1,500    Lumbermens Mutual Casualty Co.,
                    (144A), 9.15%, 7/01/26                 1,703
          2,000    U.S. West Cap Funding, Inc.,
                    6.95%, 1/15/37                         2,040
          2,500    USF&G Capital Corp., I, (144A),
                    8.50%, 12/15/45                        2,676
                                                        ---------
                                                          32,330
                                                        ---------
  TOTAL CORPORATE BONDS AND NOTES                         33,790
                                                        ---------
 ASSET BACKED SECURITIES (9.4%)
              8    Federal National Mortgage
                    Association, REMIC, 92-59F,
                    (Floating Rate), 6.088%, 8/25/06           8
          1,500    FPLUS 1997-2 M 1, 7.60%, 4/10/23        1,544
          3,003    Mid-State Trust, Class A, 8.33%,
                    4/01/30                                3,239
          2,450    Resolution Trust Corp., Series
                    1991-M5, Class A, 9.00%, 3/25/17       2,474
          4,000    Standard Credit Card Trust, 6.75%,
                    6/07/00                                4,016
          3,000    Team Fleet Financing Corp., 7.35%,
                    5/15/03                                3,091
                                                        ---------
  TOTAL ASSET BACKED SECURITIES                           14,372
                                                        ---------
TOTAL FIXED INCOME SECURITIES (Cost $143,392)            145,507
                                                        ---------
</TABLE>
 
                                       4
<PAGE>
<TABLE>
<CAPTION>
     FACE
    AMOUNT                                               AMOUNT
     (000)                                                (000)
- ---------------                                         ---------
<C>               <S>                                   <C>
SHORT-TERM INVESTMENT (4.2%)
 REPURCHASE AGREEMENT (4.2%)
$         6,437    Chase Securities, Inc. 5.75%,
                    dated 9/30/97, due 10/01/97, to
                    be repurchased at $6,438,
                    collateralized by U.S. Treasury
                    Notes, 6.25%, due 10/31/01,
                    valued at $6,571 (Cost $6,437)      $  6,437
                                                        ---------
TOTAL INVESTMENTS (98.9%) (Cost $149,829)                151,944
                                                        ---------
OTHER ASSETS AND LIABILITIES (1.1%)
  Other Assets                                             1,867
  Liabilities                                               (196)
                                                        ---------
                                                           1,671
                                                        ---------
NET ASSETS (100%)                                       $153,615
                                                        ---------
                                                        ---------
CLASS A:
NET ASSETS                                               $150,231
NET ASSET VALUE, OFFERING AND REDEMPTION
  PRICE PER SHARE
  Applicable to 13,868,404 outstanding $0.001 par
  value shares (authorized 500,000,000 shares)
                                                           $10.83
                                                        ---------
                                                        ---------
CLASS B:
NET ASSETS                                                 $3,384
NET ASSET VALUE, OFFERING AND REDEMPTION
  PRICE PER SHARE
  Applicable to 312,093 outstanding $0.001 par value
  shares (authorized 500,000,000 shares)
                                                           $10.84
                                                        ---------
                                                        ---------
</TABLE>
 
- ----------------------------------
Floating Rate Security -- Interest rate changes on these instruments are based
on changes in a designated base rate. The rates shown are those in effect on
September 30, 1997.
 
REMIC -- Real Estate Mortgage Investment Conduit
 
                                       5


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