MORGAN STANLEY INSTITUTIONAL FUND INC
497, 1997-01-21
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<PAGE>
                       SUPPLEMENT DATED DECEMBER 30, 1996
                      TO THE PROSPECTUS DATED MAY 1, 1996
                   AND SUPPLEMENTED THROUGH DECEMBER 30, 1996
 
                      ACTIVE COUNTRY ALLOCATION PORTFOLIO
 
                                PORTFOLIO OF THE
 
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                   02208-2798
                                 -------------
 
    The  Prospectus is  hereby amended  and supplemented  as follows:  Under the
heading "Management of the Fund," the third paragraph on Page 16 is deleted  and
replaced with the following:
 
        PORTFOLIO  MANAGERS.  BARTON  M. BIGGS, MADHAV  DHAR, FRANCINE J. BOVICH
AND ANN D. THIVIERGE.  Barton M. Biggs  has been Chairman and a director of  the
Adviser  since 1980 and a Managing Director  of Morgan Stanley since 1975. He is
also a director  of Morgan Stanley  Group Inc.  and a director  and chairman  of
various  registered investment companies to which the Adviser and certain of its
affiliates provide investment  advisory services.  Mr. Biggs holds  a B.A.  from
Yale  University  and an  M.B.A.  from New  York  University. Madhav  Dhar  is a
Managing Director of Morgan Stanley. He joined  the Adviser in 1984 to focus  on
global  asset allocation  and investment  strategy and now  is a  co-head of the
Adviser's emerging  markets group.  He  is a  portfolio  manager of  the  Fund's
Emerging  Markets Portfolio, the  Emerging Markets and  Global Equity Allocation
Funds of the Morgan Stanley Fund, Inc., and the Morgan Stanley Emerging  Markets
Fund,  Inc.  (a  closed-end investment  company  listed  on the  New  York Stock
Exchange). He holds a B.S. (honors) from St. Stephens College, Delhi  University
(India),  and an M.B.A. from  Carnegie-Mellon University. Francine Bovich joined
the Adviser as a Principal in 1993. She is responsible for product  development,
portfolio  management  and  communication  of  the  Adviser's  asset  allocation
strategy to  institutional  investor  clients.  Previously,  Ms.  Bovich  was  a
Principal   and   Executive  Vice   President   of  Westwood   Management  Corp.
("Westwood"), a registered investment adviser. Before joining Westwood, she  was
a  Managing  Director of  Citicorp Investment  Management, Inc.  (now Chancellor
Capital Management), where she was responsible for the Institutional  Investment
Management  Group. Ms.  Bovich began her  investment career  with Banker's Trust
Company. She holds a B.A. in Economics from Connecticut College and an M.B.A. in
Finance from New York University. Ann  Thivierge is a Principal of the  Adviser.
She  is  a  member  of  the  Adviser's  asset  allocation  committee,  primarily
representing the Total Fund Management team  since its inception in 1991.  Prior
to  joining the  Adviser in  1986, she  spent two  years at  Edgewood Management
Company, a privately held investment management firm. Ms. Thivierge holds a B.A.
in  International  Relations   from  James  Madison   College,  Michigan   State
University, and an M.B.A. in Finance from New York University.
 
                                 --------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE.
<PAGE>
                       SUPPLEMENT DATED DECEMBER 30, 1996
                        TO PROSPECTUS DATED MAY 1, 1996
                   AND SUPPLEMENTED THROUGH DECEMBER 30, 1996
 
                           EMERGING MARKETS PORTFOLIO
                        EMERGING MARKETS DEBT PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                   02208-2798
                                 -------------
 
    The Prospectus is hereby amended and supplemented to reflect the addition of
a Portfolio Manager to the Emerging Markets Portfolio.
 
    ADDITION OF PORTFOLIO MANAGER.  Marianne L. Hay has joined Madhav Dhar as a
portfolio manager with primary responsibility for managing the assets of the
Emerging Markets Portfolio. Accordingly, the second paragraph on p. 26 of the
Prospectus is deleted and replaced with the following paragraph:
 
    EMERGING MARKETS PORTFOLIO -- MADHAV DHAR AND MARIANNE L. HAY. Madhav
    Dhar is a Managing Director of Morgan Stanley. He joined the Adviser in
    1984 to focus on global asset allocation and investment strategy and now
    is a co-head of the Adviser's emerging markets group. He holds a B.S.
    (honors) from St. Stephens College, Delhi University (India), and an
    M.B.A. from Carnegie-Mellon University. Mr. Dhar has had primary
    responsibility for managing the Portfolio's assets since its inception.
    Marianne L. Hay, a Managing Director of Morgan Stanley & Co.
    Incorporated, is a co-head of the Adviser's emerging markets group and
    shares, with Mr. Dhar, primary responsibility for managing the
    Portfolio's assets. She joined the Adviser in June 1993 to work with the
    Adviser's senior management covering all emerging markets, asset
    allocation, product development and client services. Ms. Hay has 17
    years of investment experience. Prior to joining the Adviser, she was a
    director of Martin Currie Investment Management, Ltd. where her
    responsibilities included geographic asset allocation and portfolio
    management for global and emerging markets funds, as well as being
    director in charge of the company's North American clients. Prior to her
    tenure at Martin Currie Investment Management, Ltd. she worked for the
    Bank of Scotland and the investment management firm of Ivory and Sime
    plc. She graduated with an honors degree in genetics from Edinburgh
    University and holds a Diploma in Education and the qualification of the
    Association of the Institute of Bankers in Scotland.
                                 --------------
 
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<PAGE>
                       SUPPLEMENT DATED DECEMBER 30, 1996
                      TO THE PROSPECTUS DATED MAY 1, 1996
                   AND SUPPLEMENTED THROUGH DECEMBER 30, 1996
 
                           U.S. REAL ESTATE PORTFOLIO
 
                                PORTFOLIO OF THE
 
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                   02208-2798
                                 -------------
 
    The Prospectus is hereby amended and supplemented as follows: The first
sentence of the third paragraph under the heading "INVESTMENT OBJECTIVE AND
POLICIES" on page 10 is deleted and replaced by the following to clarify that
the Portfolio can invest in non-U.S. issuers principally engaged in the U.S.
real estate industry:
 
        Under normal circumstances, at least 65% of the Portfolio's total
    assets will be invested in income producing equity securities of U.S.
    and non-U.S. companies principally engaged in the U.S. real estate
    industry.
                                 --------------
 
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<PAGE>
                       SUPPLEMENT DATED DECEMBER 30, 1996
                      TO THE PROSPECTUS DATED MAY 1, 1996
                   AND SUPPLEMENTED THROUGH DECEMBER 30, 1996
 
                            EQUITY GROWTH PORTFOLIO
                           EMERGING GROWTH PORTFOLIO
                               MICROCAP PORTFOLIO
                          AGGRESSIVE EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                   02208-2798
                                 -------------
 
    The  Prospectus is  hereby amended  and supplemented  as follows:  The third
sentence in the second  paragraph under the  heading "INVESTMENT OBJECTIVES  AND
POLICIES  -- THE EQUITY GROWTH PORTFOLIO" on  page 13 is deleted and replaced by
the following:
 
        The Adviser's universe of potential investments generally  comprises
    companies with market capitalizations of $500 million or more.
                                 --------------
 
    On  page 19,  the first sentence  under the heading  "FOREIGN INVESTMENT" is
deleted and replaced by the following:
 
    The Portfolios may invest in  U.S. dollar-denominated securities of  foreign
issuers  trading  in U.S.  markets and  the Equity  Growth, Emerging  Growth and
Aggressive  Equity  Portfolios   may  invest   in  non-U.S.   dollar-denominated
securities of foreign issuers.
                                 --------------
 
    On  page 19,  the last paragraph  under the heading  "FOREIGN INVESTMENT" is
deleted and replaced by the following:
 
    Investments in securities of foreign  issuers are frequently denominated  in
foreign  currencies and, since the Equity Growth, Emerging Growth and Aggressive
Equity Portfolios may also temporarily hold uninvested reserves in bank deposits
in foreign currencies,  the value  of the  Portfolios' assets  measured in  U.S.
dollars may be affected favorably or unfavorably by changes in currency exchange
rates and in exchange control regulations, and the Portfolios may incur costs in
connection with conversions between various currencies.
                                 --------------
 
    On  page 19 the  first sentence under the  heading "FORWARD FOREIGN CURRENCY
EXCHANGE CONTRACTS" is deleted and replaced by the following:
 
    The Equity  Growth, Emerging  Growth and  Aggressive Equity  Portfolios  may
enter  into forward  foreign currency exchange  contracts ("forward contracts"),
that provide  for the  purchase or  sale of  an amount  of a  specified  foreign
currency at a future date.
                                 --------------
 
               PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE
<PAGE>
                       SUPPLEMENT DATED JANUARY 21, 1997
                        TO PROSPECTUS DATED MAY 1, 1996
 
                        SMALL CAP VALUE EQUITY PORTFOLIO
                             VALUE EQUITY PORTFOLIO
                               BALANCED PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                   02208-2798
                                 -------------
 
    The Prospectus is hereby amended and supplemented to reflect a change in
Portfolio Managers for the Small Cap Value Equity Portfolio. This Supplement
supersedes and replaces a previous Supplement dated November 18, 1996.
 
    Gary D. Haubold has resigned from Morgan Stanley Asset Management Inc. Gary
G. Schlarbaum and William B. Gerlach now have primary responsibility for
managing the assets of the Small Cap Value Equity Portfolio. Accordingly, the
third full paragraph on Page 18 is deleted and replaced with the following
paragraph:
 
    PORTFOLIO MANAGERS
 
    Stephen C. Sexauer and Alford E. Zick, Jr. have primary responsibility for
managing the Balanced Portfolio and the Value Equity Portfolio and have had such
responsibility since the Portfolios' inception in February and January, 1990,
respectively. Gary G. Schlarbaum and William B. Gerlach have had primary
responsibility for managing the Small Cap Value Equity Portfolio since January,
1997, and November, 1996, respectively.
 
Additionally, the first full paragraph on Page 19 of the Prospectus is deleted
and replaced with the following paragraphs:
 
    GARY G. SCHLARBAUM. Mr. Schlarbaum, a Managing Director of Morgan Stanley,
joined MAS in 1987. He assumed responsibility for the MAS Funds Equity and Small
Cap Value Portfolios in 1987, the MAS Funds Balanced Portfolio in 1992 and the
MAS Funds Multi-Asset-Class and Mid Cap Value Portfolios in 1994. Mr. Schlarbaum
also is a Director of MAS Fund Distribution, Inc. He previously was with First
Chicago Investment Advisers and was a Professor at the Krannert Graduate School
at Purdue University. Mr. Schlarbaum holds a B.A. in Economics from Coe College
and a Ph.D. in Applied Economics from University of Pennsylvania.
 
    WILLIAM B. GERLACH. Mr. Gerlach joined the Adviser in July 1996 and has
worked with the Adviser's affiliate, Miller Anderson & Sherrerd, LLP for the
past five years. He assumed responsibility for the MAS Funds Small Cap Value and
Mid Cap Value Portfolios in 1996. Previously, he was with Alphametrics
Corporation and Wharton Econometric Forecasting Associates. Mr. Gerlach received
a B.A. in Economics from Haverford College.
                                 --------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE.


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