MORGAN STANLEY INSTITUTIONAL FUND INC
497, 1997-09-10
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                       SUPPLEMENT DATED SEPTEMBER 9, 1997
                       TO PROSPECTUS DATED JULY 21, 1997
 
                           U.S. EQUITY PLUS PORTFOLIO
                               A PORTFOLIO OF THE
              MORGAN STANLEY INSTITUTIONAL FUND, INC. (THE "FUND")
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                   02208-2798
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    The Prospectus is being amended and supplemented to: (i) reflect changes to
the parent of the investment adviser, administrator and the distributor; and
(ii) detail the Portfolio's revised investment policies with respect to certain
derivative instruments. The Prospectus is amended and supplemented as follows:
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    On May 31, 1997, Morgan Stanley Group Inc. and Dean Witter, Discover & Co.
merged to form Morgan Stanley, Dean Witter, Discover & Co. Prior thereto, Morgan
Stanley Group Inc. was the direct parent of Morgan Stanley Asset Management Inc.
(the "Adviser") and Morgan Stanley & Co. Incorporated ("Morgan Stanley"). The
Adviser and Morgan Stanley are now subsidiaries of Morgan Stanley, Dean Witter,
Discover & Co.
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    After the section entitled "WHEN-ISSUED AND DELAYED DELIVERY SECURITIES" on
pages 9-10, the following sections are inserted:
 
    DERIVATIVE INSTRUMENTS
 
        The Portfolio is permitted to invest in various derivative
    instruments for both hedging and non-hedging purposes. Derivatives
    instruments include options, futures and options on futures, structured
    investments and structured notes, caps, floors, collars and swaps.
    Additionally, the Portfolio may invest in other derivative instruments
    that are developed over time if their use would be consistent with the
    objectives of the Portfolio. The Portfolio will limit its use of
    derivative instruments to 33 1/3% of its total assets measured by the
    aggregate notional amount of outstanding derivative instruments. The
    Portfolio's investments in forward foreign currency contracts and
    derivatives used for hedging purposes are not subject to the limit
    described above.
 
        The Portfolio may use derivative instruments under a number of
    different circumstances to further its investment objectives. The
    Portfolio may use derivatives when doing so provides more liquidity than
    the direct purchase of the securities underlying such derivatives. For
    example, the Portfolio may purchase derivatives to quickly gain exposure
    to a market in response to changes in the Portfolio's investment policy
    or upon the inflow of investable cash or when the derivative provides
    greater liquidity than the underlying securities market. The Portfolio
    may also use derivatives when it is restricted from directly owning the
    underlying securities due to foreign investment restrictions or other
    reasons or when doing so provides a price advantage over purchasing the
    underlying securities directly, either because of a pricing differential
    between the derivatives and securities markets or because of lower
    transaction costs associated with the derivatives transaction.
    Derivatives may also be used by the Portfolio for hedging purposes and
    in other circumstances when the Portfolio's portfolio
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    managers believe it advantageous to do so consistent with the
    Portfolio's investment objective. The Portfolio will not, however, use
    derivatives in a manner that creates leverage, except to the extent that
    the use of leverage is expressly permitted by the Portfolio's investment
    policies, and then only in a manner consistent with such policies.
 
        Some of the derivative instruments in which the Portfolio may invest
    and the risks related thereto are described in more detail below.
 
    CAPS, FLOORS AND COLLARS
 
        The Portfolio may invest in caps, floors and collars, which are
    instruments analogous to options. In particular, a cap is the right to
    receive the excess of a reference rate over a given rate and is
    analogous to a put option. A floor is the right to receive the excess of
    a given rate over a reference rate and is analogous to a call option.
    Finally, a collar is an instrument that combines a cap and a floor. That
    is, the buyer of a collar buys a cap and writes a floor, and the writer
    of a collar writes a cap and buys a floor. The risks associated with
    caps, floors and collars are similar to those associated with options.
    In addition, caps, floors and collars are subject to risk of default by
    the counterparty because they are privately negotiated instruments.
 
    FUTURES CONTRACTS AND OPTIONS ON FUTURES CONTRACTS
 
        The Portfolio may purchase and sell futures contracts and options on
    futures contracts, including but not limited to securities index
    futures, foreign currency exchange futures, interest rate futures
    contracts and other financial futures. Futures contracts provide for the
    sale by one party and purchase by another party of a specified amount of
    a specific security, instrument or basket thereof, at a specific future
    date and at a specified price. An option on a futures contract is a
    legal contract that gives the holder the right to buy or sell a
    specified amount of futures contracts at a fixed or determinable price
    upon the exercise of the option.
 
        The Portfolio may sell securities index futures contracts and/or
    options thereon in anticipation of or during a market decline to attempt
    to offset the decrease in market value of investments in its portfolio,
    or purchase securities index futures in order to gain market exposure.
    Subject to applicable laws, the Portfolio may engage in transactions in
    securities index futures contracts (and options thereon) which are
    traded on a recognized securities or futures exchange, or may purchase
    or sell such instruments in the over-the-counter market. There currently
    are limited securities index futures and options on such futures in many
    countries, particularly emerging countries. The nature of the strategies
    adopted by the Adviser, and the extent to which those strategies are
    used, may depend on the development of such markets.
 
        The Portfolio may engage in transactions involving foreign currency
    exchange futures contracts. Such contracts involve an obligation to
    purchase or sell a specific currency at a specified future date and at a
    specified price. The Portfolio may engage in such transactions to hedge
    their respective holdings and commitments against changes in the level
    of future currency rates or to adjust their exposure to a particular
    currency.
 
        The Portfolio may engage in transactions in interest rate futures
    transactions. Interest rate futures contracts involve an obligation to
    purchase or sell a specific debt security, instrument or basket thereof
    at a specified future date at a specified price. The value of the
    contract rises and falls inversely with
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    changes in interest rates. The Portfolio may engage in such transactions
    to hedge its holdings of debt instruments against future changes in
    interest rates.
 
        Financial futures are futures contracts relating to financial
    instruments, such as U.S. Government securities, foreign currencies, and
    certificates of deposit. Such contracts involve an obligation to
    purchase or sell a specific security, instrument or basket thereof at a
    specified future date at a specified price. Like interest rate futures
    contracts, the value of financial futures contracts rises and falls
    inversely with changes in interest rates. The Portfolio may engage in
    financial futures contracts for hedging and non-hedging purposes.
 
        Under rules adopted by the Commodity Futures Trading Commission, the
    Portfolio may enter into futures contracts and options thereon for both
    hedging and non-hedging purposes, provided that not more than 5% of the
    Portfolio's total assets at the time of entering the transaction are
    required as margin and option premiums to secure obligations under such
    contracts relating to non-hedging activities.
 
        Gains and losses on futures contracts and options thereon depend on
    the Adviser's ability to predict correctly the direction of securities
    prices, interest rates and other economic factors. Other risks
    associated with the use of futures and options are (i) imperfect
    correlation between the change in market value of investments held by
    the Portfolio and the prices of futures and options relating to
    investments purchased or sold by the Portfolio, and (ii) possible lack
    of a liquid secondary market for a futures contract and the resulting
    inability to close a futures position. The risk that the Portfolio will
    be unable to close out a futures position or options contract will be
    minimized by only entering into futures contracts or options
    transactions for which there appears to be a liquid exchange or
    secondary market. The risk of loss in trading on futures contracts in
    some strategies can be substantial, due both to the low margin deposits
    required and the extremely high degree of leverage involved in futures
    pricing.
 
    OPTIONS TRANSACTIONS
 
        The Portfolio may seek to increase its return or may hedge its
    portfolio investments through options transactions with respect to
    securities, instruments, indices or baskets thereof in which the
    Portfolio may invest, as well as with respect to foreign currency.
    Purchasing a put option gives the Portfolio the right to sell a
    specified security, currency or basket of securities or currencies at
    the exercise price until the expiration of the option. Purchasing a call
    option gives the Portfolio the right to purchase a specified security,
    currency or basket of securities or currencies at the exercise price
    until the expiration of the option.
 
        The Portfolio also may write (i.e., sell) put and call options on
    investments held in its portfolio, as well as with respect to foreign
    currency. When the Portfolio has written an option, it receives a
    premium, which increases the Portfolio's return on the underlying
    security or instrument in the event the option expires unexercised or is
    closed out at a profit. However, by writing a call option, the Portfolio
    will limit its opportunity to profit from an increase in the market
    value of the underlying security or instrument above the exercise price
    of the option for as long as the Portfolio's obligation as writer of the
    option continues. The Portfolio may only write options that are
    "covered." A covered call option means that so long as the Portfolio is
    obligated as the writer of the option, it will earmark or segregate
    sufficient liquid assets to cover its obligations under the option or
    own (i) the underlying security or instrument subject to the option,
    (ii) securities or instruments convertible or exchangeable
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    without the payment of any consideration into the security or instrument
    subject to the option, or (iii) a call option on the same underlying
    security with a strike price no higher than the price at which the
    underlying instrument was sold pursuant to a short option position.
 
        By writing (or selling) a put option, the Portfolio incurs an
    obligation to buy the security or instrument underlying the option from
    the purchaser of the put at the option's exercise price at any time
    during the option period, at the purchaser's election. The Portfolio may
    also write options that may be exercised by the purchaser only on a
    specific date. The Portfolio that has written a put option will earmark
    or segregate sufficient liquid assets to cover its obligations under the
    option or will own a put option on the same underlying security with an
    equal or higher strike price.
 
        The Portfolio may engage in transactions in options which are traded
    on recognized exchanges or over-the-counter. There currently are limited
    options markets in many countries, particularly emerging countries such
    as Latin American countries, and the nature of the strategies adopted by
    the Adviser and the extent to which those strategies are used will
    depend on the development of such options markets. The primary risks
    associated with the use of options are (i) imperfect correlation between
    the change in market value of investments held, purchased or sold by the
    Portfolio and the prices of options relating to such investments, and
    (ii) possible lack of a liquid secondary market for an option.
 
    STRUCTURED NOTES
 
        Structured Notes are derivatives on which the amount of principal
    repayment and/or interest payments is based upon the movement of one or
    more factors. These factors include, but are not limited to, currency
    exchange rates, interest rates (such as the prime lending rate and
    LIBOR) and stock indices such as the S&P 500 Index. In some cases, the
    impact of the movements of these factors may increase or decrease
    through the use of multipliers or deflators. The Portfolio may use
    structured notes to tailor its investments to the specific risks and
    returns the Adviser wishes to accept while avoiding or reducing certain
    other risks.
 
    SWAPS -- SWAP CONTRACTS
 
        Swaps and Swap Contracts are derivatives in the form of a contract
    or other similar instrument in which two parties agree to exchange the
    returns generated by a security, instrument, basket or index thereof for
    the returns generated by another security, instrument, basket thereof or
    index. The payment streams are calculated by reference to a specific
    security, index or instrument and an agreed upon notional amount. The
    relevant indices include but are not limited to, currencies, fixed
    interest rates, prices and total return on interest rate indices, fixed
    income indices, stock indices and commodity indices (as well as amounts
    derived from arithmetic operations on these indices). For example, the
    Portfolio may agree to swap the return generated by a fixed income index
    for the return generated by a second fixed income index. The currency
    swaps in which the Portfolio may enter will generally involve an
    agreement to pay interest streams in one currency based on a specified
    index in exchange for receiving interest streams denominated in another
    currency. Such swaps may involve initial and final exchanges that
    correspond to the agreed upon notional amount.
 
        The Portfolio will usually enter into swaps on a net basis, i.e.,
    the two return streams are netted out in a cash settlement on the
    payment date or dates specified in the instrument, with the Portfolio
    receiving or paying, as the case may be, only the net amount of the two
    returns. The Portfolio's obligations under a swap agreement will be
    accrued daily (offset against any amounts owing to the
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    Portfolio) and any accrued, but unpaid, net amounts owed to a swap
    counterparty will be covered by the maintenance of a segregated account
    consisting of cash or liquid securities. The Portfolio will not enter
    into any swap agreement unless the counterparty meets the rating
    requirements set forth in guidelines established by the Fund's Board of
    Directors.
 
        Interest rate and total rate of return swaps do not involve the
    delivery of securities, other underlying assets, or principal.
    Accordingly, the risk of loss with respect to interest rate and total
    rate of return swaps is limited to the net amount of payments that the
    Portfolio is contractually obligated to make. If the other party to an
    interest rate or total rate of return swap defaults, the Portfolio's
    risk of loss consists of the net amount of payments that the Portfolio
    is contractually entitled to receive. In contrast, currency swaps may
    involve the delivery of the entire principal value of one designated
    currency in exchange for the other designated currency. Therefore, the
    entire principal value of a currency swap may be subject to the risk
    that the other party to the swap will default on its contractual
    delivery obligations. If there is a default by the counterparty, the
    Portfolio may have contractual remedies pursuant to the agreements
    related to the transaction. The swaps market has grown substantially in
    recent years with a large number of banks and investment banking firms
    acting both as principals and as agents utilizing standardized swap
    documentation. As a result, the swaps market has become relatively
    liquid. Swaps that include caps, floors and collars are more recent
    innovations for which standardized documentation has not yet been fully
    developed and, accordingly, they are less liquid than "traditional"
    swaps.
 
        The use of swaps is a highly specialized activity which involves
    investment techniques and risks different from those associated with
    ordinary portfolio securities transactions. If the Adviser is incorrect
    in its forecasts of market values, interest rates, and currency exchange
    rates, the investment performance of the Portfolio would be less
    favorable than it would have been if this investment technique were not
    used.
 
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