MORGAN STANLEY INSTITUTIONAL FUND INC
497, 1997-09-26
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<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
- --------------------------------------------------------------------------------
 
                             ASIAN EQUITY PORTFOLIO
                           JAPANESE EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
 
                                ----------------
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a series of diversified and non-diversified investment portfolios
("portfolios"). The Fund is designed to provide clients with attractive
alternatives for meeting their investment needs. The Fund currently consists of
thirty-two portfolios representing a broad range of investment choices. This
prospectus (the "Prospectus") pertains to the Class A and the Class B shares of
the Asian Equity and Japanese Equity Portfolios (each, a "Portfolio" and
collectively, the "Portfolios"). The Class A and Class B shares currently
offered by the Portfolios have different minimum investment requirements and
fund expenses. Shares of the portfolios are offered with no sales charge,
exchange fee or redemption fee (except that the International Small Cap
Portfolio may impose a transaction fee).
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator"), and with Morgan Stanley as Distributor, the Fund makes
available to institutional and high net worth individual investors a series of
portfolios which benefit from the investment expertise and commitment to
excellence associated with Morgan Stanley and its affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under "Prospectus Summary" below. The Fund
currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging Markets,
European Equity, European Real Estate, Global Equity, Gold, International
Equity, International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) EQUITY AND FIXED INCOME -- Balanced
Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global
Fixed Income, High Yield and Municipal Bond Portfolios; and (v) MONEY MARKET --
Money Market and Municipal Money Market Portfolios. Additional information about
the Fund is contained in a "Statement of Additional Information," dated May 1,
1997 as supplemented through September 26, 1997, which is incorporated herein by
reference. The Statement of Additional Information and the prospectuses
pertaining to the other portfolios of the Fund are available upon request and
without charge by writing or calling the Fund at the address and telephone
number set forth above.
 
 THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
   EXCHANGE COMMISSION, NOR HAS THE SECURITIES AND EXCHANGE COMMISSION
    PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY
             REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
                   THE DATE OF THIS PROSPECTUS IS MAY 1, 1997
                   AS SUPPLEMENTED THROUGH SEPTEMBER 26, 1997
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates the expenses and fees that a shareholder of
each Portfolio listed below will incur.
 
<TABLE>
<CAPTION>
                                                                                        ASIAN EQUITY     JAPANESE EQUITY
SHAREHOLDER TRANSACTION EXPENSES                                                          PORTFOLIO         PORTFOLIO
- -------------------------------------------------------------------------------------  ---------------  -----------------
<S>                                                                                    <C>              <C>
Maximum Sales Load Imposed on Purchases
  Class A............................................................................          None              None
  Class B............................................................................          None              None
Maximum Sales Load Imposed on Reinvested Dividends
  Class A............................................................................          None              None
  Class B............................................................................          None              None
Deferred Sales Load
  Class A............................................................................          None              None
  Class B............................................................................          None              None
Redemption Fees
  Class A............................................................................          None              None
  Class B............................................................................          None              None
Exchange Fees
  Class A............................................................................          None              None
  Class B............................................................................          None              None
</TABLE>
 
<TABLE>
<CAPTION>
                                                     ASIAN
                                                    EQUITY     JAPANESE EQUITY
ANNUAL FUND OPERATING EXPENSES                     PORTFOLIO      PORTFOLIO
- ------------------------------------------------  -----------  ---------------
 (AS A PERCENTAGE OF AVERAGE NET ASSETS)
<S>                                               <C>          <C>
Management Fee (Net of Fee Waivers)*
  Class A.......................................       0.55%          0.73%
  Class B.......................................       0.55%          0.73%
12b-1 Fees
  Class A.......................................        None           None
  Class B.......................................       0.25%          0.25%
Other Expenses
  Class A.......................................       0.45%          0.27%
  Class B.......................................       0.45%          0.27%
                                                  -----------       -------
Total Operating Expenses (Net of Fee Waivers)
  Class A.......................................       1.00%          1.00%
  Class B.......................................       1.25%          1.25%
                                                  -----------       -------
                                                  -----------       -------
</TABLE>
 
 * The Adviser has agreed to waive its management fees and/or reimburse each
   Portfolio, if necessary, if such fees would cause the total annual operating
   expenses of the Portfolios to exceed a specified percentage of their
   respective average daily net assets. As a result of these reductions, the
   Management Fees stated above are lower than the contractual fees stated under
   "Management of the Fund." The Adviser reserves the right to terminate any of
   its fee waivers and/or expense reimbursements at any time in its sole
   discretion. For further information on Fund expenses, see "Management of the
   Fund." Set forth below, for each Portfolio, as applicable, are the management
   fees and total operating expenses absent such fee waivers and/or expense
   reimbursements as a percent of average daily net assets of the Class A and
   Class B shares of the Portfolios.
 
<TABLE>
<CAPTION>
                                                                                           TOTAL
                                                                                     OPERATING EXPENSES
                                                                                           ABSENT
                                                                  MANAGEMENT            FEE WAIVERS
                                                                FEES ABSENT FEE  --------------------------
PORTFOLIO                                                           WAIVERS        CLASS A       CLASS B
- --------------------------------------------------------------  ---------------  ------------  ------------
<S>                                                             <C>              <C>           <C>
Asian Equity..................................................         0.80%           1.25%         1.52%
Japanese Equity...............................................         0.80%           1.07%         1.31%
</TABLE>
 
                                       2
<PAGE>
    The purpose of the table is to assist the investor in understanding the
various expenses that an investor in the Portfolios will bear directly or
indirectly. Expenses and fees are based on actual figures for the fiscal year
ended December 31, 1996. Due to the continuous nature of Rule 12b-1 fees,
long-term Class B shareholders may pay more than the equivalent of the maximum
front-end sales charges otherwise permitted by the National Association of
Securities Dealers, Inc. ("NASD") Conduct Rules.
 
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (1) a 5% annual rate of return and (2) redemption at
the end of each time period. As noted in the table above, the Portfolios charge
no redemption fees of any kind. The following example is based on total
operating expenses of the Portfolios after fee waivers.
 
<TABLE>
<CAPTION>
                                               3       5       10
                                     1 YEAR  YEARS   YEARS    YEARS
                                     ------  ------  ------  -------
<S>                                  <C>     <C>     <C>     <C>
Asian Equity Portfolio
  Class A..........................  $  10   $  32   $  55   $  122
  Class B..........................     13      40      69      151
Japanese Equity Portfolio
  Class A..........................     10      32      55      122
  Class B..........................     13      40      69      151
</TABLE>
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. ACTUAL EXPENSES MAY BE GREATER OR LESS THAN THOSE
SHOWN.
 
                                       3
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following tables provide financial highlights for the Class A and Class
B shares of the Portfolios for each of the periods presented. The audited
financial highlights for the Portfolios' shares for each of the periods
presented are part of the Fund's financial statements which appear in the Fund's
December 31, 1996 Annual Report to Shareholders and which are incorporated by
reference into the Fund's Statement of Additional Information. The Portfolios'
financial highlights for each of the periods presented have been audited by
Price Waterhouse LLP, whose unqualified report thereon is also incorporated by
reference into the Statement of Additional Information. Additional performance
information is included in the Annual Report. The Annual Report and the
financial statements therein, along with the Statement of Additional
Information, are available at no cost from the Fund at the address and telephone
number noted on the cover page of this Prospectus. After October 31, 1992, the
Fund changed its fiscal year end to December 31. The following information
should be read in conjunction with financial statements and notes thereto.
 
                                       4
<PAGE>
                             ASIAN EQUITY PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                                                                      CLASS B
                                                                  CLASS A                                           ------------
                           --------------------------------------------------------------------------------------   PERIOD FROM
                                                                                        TWO MONTHS                   JANUARY 2,
                            YEAR ENDED     YEAR ENDED     YEAR ENDED     YEAR ENDED       ENDED       YEAR ENDED     1996*** TO
                           DECEMBER 31,   DECEMBER 31,   DECEMBER 31,   DECEMBER 31,   DECEMBER 31,   OCTOBER 31,   DECEMBER 31,
                               1996           1995           1994           1993           1992          1992           1996
                           ------------   ------------   ------------   ------------   ------------   -----------   ------------
<S>                        <C>            <C>            <C>            <C>            <C>            <C>           <C>
NET ASSET VALUE,
 BEGINNING OF PERIOD.....    $ 19.48        $  21.54       $  26.20       $  13.11       $  13.63       $  9.67       $  19.55
                           ------------   ------------   ------------   ------------   ------------   -----------   ------------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Income
   (1)...................       0.17            0.18           0.11           0.10           0.01          0.14           0.11
  Net Realized and
   Unrealized Gain (Loss)
   on Investments........       0.50            1.11          (4.15)         13.38          (0.53)         3.86           0.46
                           ------------   ------------   ------------   ------------   ------------   -----------   ------------
    Total from Investment
     Operations..........       0.67            1.29          (4.04)         13.48          (0.52)         4.00           0.57
                           ------------   ------------   ------------   ------------   ------------   -----------   ------------
DISTRIBUTIONS
  Net Investment
   Income................      (0.15)          (0.34)         (0.09)         (0.01)            --         (0.04)         (0.11)
  In Excess of Net
   Investment Income.....      (0.00)+         (0.00+            --          (0.13)            --            --             --
  Net Realized Gain......      (1.27)          (3.01)         (0.53)         (0.12)            --            --          (1.27)
  In Excess of Net
   Realized Gain.........         --              --             --          (0.13)            --            --             --
                           ------------   ------------   ------------   ------------   ------------   -----------   ------------
    Total
     Distributions.......      (1.42)          (3.35)         (0.62)         (0.39)            --         (0.04)         (1.38)
                           ------------   ------------   ------------   ------------   ------------   -----------   ------------
NET ASSET VALUE, END OF
 PERIOD..................    $ 18.73        $  19.48       $  21.54       $  26.20       $  13.11       $ 13.63       $  18.74
                           ------------   ------------   ------------   ------------   ------------   -----------   ------------
                           ------------   ------------   ------------   ------------   ------------   -----------   ------------
TOTAL RETURN.............       3.49%           6.87%        (15.81)%       105.71%         (3.82)%       41.50%         2.92%
                           ------------   ------------   ------------   ------------   ------------   -----------   ------------
                           ------------   ------------   ------------   ------------   ------------   -----------   ------------
RATIOS AND SUPPLEMENTAL
 DATA:
  Net Assets, End of
   Period (Thousands)....    $363,498       $314,884       $276,906       $287,136       $ 41,978       $41,017       $ 11,002
  Ratio of Expenses to
   Average Net Assets
   (1)...................       1.00%           1.00%          1.00%          1.00%          1.00%**       1.00%          1.25%**
  Ratio of Net Investment
   Income to Average Net
   Assets (1)............       0.74%           0.97%          0.52%          0.83%          0.61%**       1.53%          0.58%**
  Portfolio Turnover
   Rate..................         69%             42%            47%            18%            10%           33%            69%
  Average Commission
   Rate#.................    $0.0111             N/A            N/A            N/A            N/A           N/A        $0.0111
</TABLE>
 
- ------------------------------
 
<TABLE>
<C> <S>                     <C>             <C>            <C>            <C>            <C>           <C>            <C>
(1) Effect of voluntary
     expense limitation
     during the period:
      Per share benefit
       to net
       investment
       income............      $0.05           $0.03          $0.04          $0.05          $0.02         $0.06          $0.04
    Ratios before expense
     limitation:
      Expenses to Average
       Net Assets........       1.25%           1.18%          1.20%          1.38%          2.02%**       1.63%          1.52%**
      Net Investment
       Income (Loss) to
       Average Net
       Assets............       0.54%           0.79%          0.32%          0.45%        (0.41)%**       0.90%          0.37%**
</TABLE>
 
 ** Annualized
 
*** The Portfolio began offering Class B Shares on January 2, 1996.
 
  + Amount is less than $0.01 per share.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period. For the year ended December 31,
   1996, the average commission rate paid on trades on which commissions were
 
   charged was 0.52% of the trade amount.
 
                                       5
<PAGE>
                           JAPANESE EQUITY PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                  CLASS A                         CLASS B
                                               ---------------------------------------------   -------------
                                                                                PERIOD FROM     PERIOD FROM
                                                                                 APRIL 25,      JANUARY 2,
                                                YEAR ENDED      YEAR ENDED       1994* TO       1996*** TO
                                               DECEMBER 31,    DECEMBER 31,    DECEMBER 31,    DECEMBER 31,
                                                  1996++           1995            1994           1996++
                                               -------------   -------------   -------------   -------------
<S>                                            <C>             <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........  $    9.27       $    9.83       $   10.00       $    9.25
                                               -------------   -------------   -------------   -------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (Loss) (1)...........         --            0.04           (0.01)          (0.02)
  Net Realized and Unrealized Loss on
   Investments+..............................      (0.13)          (0.40)          (0.16)          (0.14)
                                               -------------   -------------   -------------   -------------
    Total from Investment Operations.........      (0.13)          (0.36)          (0.17)          (0.16)
                                               -------------   -------------   -------------   -------------
DISTRIBUTIONS
  Net Investment Income......................      (0.66)             --              --           (0.64)
  In Excess of Net Investment Income.........      (0.52)          (0.20)             --           (0.51)
                                               -------------   -------------   -------------   -------------
    Total Distributions......................      (1.18)          (0.20)             --           (1.15)
                                               -------------   -------------   -------------   -------------
NET ASSET VALUE, END OF PERIOD...............  $    7.96       $    9.27       $    9.83       $    7.94
                                               -------------   -------------   -------------   -------------
                                               -------------   -------------   -------------   -------------
TOTAL RETURN.................................      (1.40)%         (3.64)%         (1.70)%         (1.67)%
                                               -------------   -------------   -------------   -------------
                                               -------------   -------------   -------------   -------------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)......  $ 152,229       $ 119,278       $  50,332          $3,431
  Ratio of Expenses to Average Net Assets
   (1).......................................       1.00%           1.00%           1.00%**         1.25%**
  Ratio of Net Investment Income (Loss) to
   Average Net Assets (1)....................      (0.04)%          0.15%          (0.10)%**       (0.26)%**
  Portfolio Turnover Rate....................         38%             52%              1%             38%
  Average Commission Rate#...................    $0.0561             N/A             N/A         $0.0561
</TABLE>
 
- ------------------------
 
<TABLE>
<C> <S>                                         <C>             <C>             <C>             <C>
(1) Effect of voluntary expense limitation
     during the period:
      Per share benefit to net investment
       income (loss).........................      $0.01           $0.06           $0.02           $0.01
    Ratios before expense limitation:
      Expenses to Average Net Assets.........       1.07%           1.20%           1.27%**         1.31%**
      Net Investment Income (Loss) to Average
       Net Assets............................      (0.11)%         (0.05)%         (0.37)%**       (0.32)%**
</TABLE>
 
  * Commencement of operations.
 
 ** Annualized
 
*** The Portfolio began offering Class B Shares on January 2, 1996.
 
  + The amount shown for the year ended December 31, 1995 for a share
    outstanding throughout the year does not agree with the amount of aggregate
    net gains on investments for the year because of the timing of sales and
    repurchases of the Portfolio shares in relation to fluctuating market value
    of the investments in the Portfolio.
 
 ++ Per share amounts for the year ended December 31, 1996 are based on average
    outstanding shares.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period. For the year ended December 31,
   1996, the average commission rate paid on trades on which commissions were
   charged was 0.43% of the trade amount.
 
                                       6
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and high net worth individual investors a broad range of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates providing customized services as Adviser, Administrator and
Distributor. Each portfolio offers Class A shares and, except for the
International Small Cap, Money Market and Municipal Money Market Portfolios,
also offers Class B shares. Each portfolio has its own investment objective and
policies designed to meet its specific goals. The investment objective of each
Portfolio described in this Prospectus is as follows:
 
    -The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Asian issuers.
 
    -The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Japanese issuers.
 
    The other portfolios of the Fund are described in other prospectuses which
may be obtained from the Fund at the address and phone number noted on the cover
page of this Prospectus. The investment objectives of these other portfolios are
listed below:
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    -The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
     appreciation by investing in accordance with country weightings determined
     by the Adviser in equity securities of non-U.S. issuers which, in the
     aggregate, replicate broad country indices.
 
    -The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
     appreciation by investing primarily in equity securities of companies in
     the Asian real estate industry.
 
    -The CHINA GROWTH PORTFOLIO seeks to provide long-term capital appreciation
     by investing primarily in equity securities of issuers in The People's
     Republic of China, Hong Kong and Taiwan.
 
    -The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of emerging country issuers.
 
    -The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of European issuers.
 
    -The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income and
     long-term capital appreciation by investing primarily in equity securities
     of companies in the European real estate industry.
 
    -The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers throughout the world,
     including U.S. issuers.
 
    -The GOLD PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of foreign and domestic issuers engaged in
     gold-related activities.
 
    -The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers.
 
    -The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers domiciled in
     EAFE countries.
 
                                       7
<PAGE>
    -The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
     by investing primarily in equity securities of non-U.S. issuers with equity
     market capitalizations of less than $1 billion.
 
    -The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Latin American issuers and,
     from time to time, debt securities issued or guaranteed by Latin American
     governments or governmental entities.
 
    U.S. EQUITY:
 
    -The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by investing
     primarily in corporate equity and equity-linked securities.
 
    -The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing primarily in growth-oriented equity securities of small- to
     medium-sized corporations.
 
    -The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing in growth-oriented equity securities of medium and large
     capitalization companies.
 
    -The MICROCAP PORTFOLIO seeks long-term capital appreciation by investing
     primarily in growth-oriented equity securities of small corporations.
 
    -The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total return by
     investing in undervalued equity securities of small- to medium-sized
     companies.
 
    -The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of companies that, in the opinion of the
     Portfolio's investment adviser, are expected to benefit from their
     involvement in technology and technology-related industries.
 
    -The U.S. EQUITY PLUS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers included in the S&P 500
     Index ("S&P 500").
 
    -The U.S. REAL ESTATE PORTFOLIO seeks to provide above average current
     income and long-term capital appreciation by investing primarily in equity
     securities of companies in the U.S. real estate industry, including real
     estate investment trusts.
 
    -The VALUE EQUITY PORTFOLIO seeks high total return by investing in equity
     securities which the Adviser believes to be undervalued relative to the
     stock market in general at the time of purchase.
 
    EQUITY AND FIXED INCOME:
 
    -The BALANCED PORTFOLIO seeks high total return while preserving capital by
     investing in a combination of undervalued equity securities and fixed
     income securities.
 
    FIXED INCOME:
 
    -The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by investing
     primarily in debt securities of government, government-related and
     corporate issuers located in emerging countries.
 
    -The FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
     with the preservation of capital by investing in a diversified portfolio of
     fixed income securities.
 
    -The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
     of return while preserving capital by investing in fixed income securities
     of issuers throughout the world, including U.S. issuers.
 
                                       8
<PAGE>
    -The HIGH YIELD PORTFOLIO seeks to maximize total return by investing in a
     diversified portfolio of high yield fixed income securities that offer a
     yield above that generally available on debt securities in the four highest
     rating categories of the recognized rating services.
 
    -The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a level
     of current income as is consistent with the preservation of capital by
     investing primarily in a variety of investment-grade mortgage-backed
     securities.
 
    -The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of current
     income consistent with preservation of principal by investing primarily in
     municipal obligations, the interest on which is exempt from federal income
     tax.
 
    MONEY MARKET:
 
    -The MONEY MARKET PORTFOLIO seeks to maximize current income and preserve
     capital while maintaining high levels of liquidity through investing in
     high-quality money market instruments with remaining maturities of one year
     or less.
 
    -
    The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current tax-exempt
    income and preserve capital while maintaining high levels of liquidity
    through investing in high-quality money market instruments with remaining
    maturities of one year or less which are exempt from federal income tax.
 
    THE CHINA GROWTH, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS ARE
    CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley, Dean Witter, Discover & Co., acts as investment adviser to the Fund and
each of its portfolios. As of August 31, 1997, Morgan Stanley Asset Management
Inc. and its affiliated asset management companies (exclusive of Miller Anderson
& Sherrerd, LLP, Van Kampen American Capital, Inc. and Dean Witter InterCapital
Inc.) managed assets of approximately $80.9 billion. See "Management of the Fund
- -- Investment Adviser" and "Management of the Fund -- Administrator."
 
HOW TO INVEST
 
    Class A shares of each Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of each
Portfolio are offered at net asset value with no sales commission, but with a
12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25% of the
Class B shares' average daily net assets on an annualized basis. Share purchases
may be made by sending investments directly to the Fund or through the
Distributor. The minimum initial investment, generally, is $500,000 for Class A
shares of each Portfolio and $100,000 for Class B shares of each Portfolio. The
minimum initial investment amount is reduced for certain categories of
investors. For additional information on how to purchase shares and minimum
initial investments, see "Purchase of Shares."
 
HOW TO REDEEM
 
    Shares of each Portfolio may be redeemed at any time, without cost, at the
net asset value per share of shares of the applicable class next determined
after receipt of the redemption request. The redemption price may be more or
less than the purchase price. Certain redemptions that cause the value of an
account to remain for a continuous 60-day period below the minimum investment
amount for Class A shares or for Class B shares
 
                                       9
<PAGE>
may result in involuntary redemption or automatic conversion. For additional
information on how to redeem shares and involuntary redemption or conversion,
see "Purchase of Shares -- Minimum Account Sizes and Involuntary Redemption of
Shares" and "Redemption of Shares."
 
RISK FACTORS
 
    The investment policies of each of the Portfolios entail certain risks and
considerations of which an investor should be aware. Each Portfolio will invest
in securities of foreign issuers, which are subject to certain risks not
typically associated with domestic securities. Each Portfolio may invest in
securities of issuers located in emerging markets. These securities may impose
greater liquidity risks and other risks not typically associated with investing
in more established markets. In addition, each Portfolio may invest in
repurchase agreements, lend its portfolio securities, purchase securities on a
when-issued or delayed delivery basis and invest in foreign currency forward
contracts. The Portfolios may invest in certain derivatives, including options,
futures and options on futures, caps, floors and collars, swaps and structured
investments. These investments entail certain costs and risks, including
imperfect correlation between the value of securities held by the Portfolio and
the value of the particular derivative instrument, and the risk that the
Portfolio could not close out a derivatives position when it would be most
advantageous to do so. The Asian Equity Portfolio may invest in securities that
are neither listed on a stock exchange nor traded over-the-counter, including
private placement securities. The Portfolios may also invest indirectly in
securities through sponsored or unsponsored Depositary Receipts. Each of these
investment strategies involves specific risks which are described under
"Investment Objectives and Policies" and "Additional Investment Information"
herein and under "Investment Objectives and Policies" in the Statement of
Additional Information.
 
                                       10
<PAGE>
                       INVESTMENT OBJECTIVES AND POLICIES
 
    The investment objective of each Portfolio is described below, together with
the policies the Portfolios employ in their efforts to achieve these objectives.
Each Portfolio's investment objective is a fundamental policy which may not be
changed without the approval of a majority of the Portfolio's outstanding voting
securities. There is no assurance that the Portfolios will attain their
objectives. Each of the Portfolios invests in equity securities, which include
common and preferred stocks, convertible securities, rights and warrants to
purchase common stocks. In addition to the investments and strategies described
below, the Portfolios may invest in certain securities and obligations as set
forth in "Additional Investment Information" below. The investment policies
described below are not fundamental policies and may be changed without
shareholder approval.
 
THE ASIAN EQUITY PORTFOLIO
 
    The investment objective of the Asian Equity Portfolio is to provide
long-term capital appreciation. The production of any current income is
incidental to this objective. The Portfolio seeks to achieve its objective by
investing primarily in equity securities which are traded on recognized stock
exchanges of the countries in Asia described below and in equity securities of
companies organized under the laws of an Asian country whose business is
conducted principally in Asia. The Portfolio does not intend to invest in equity
securities which are principally traded in markets in Japan or in companies
organized under the laws of Japan. The Portfolio may also invest in Depositary
Receipts of Asian issuers.
 
    The Portfolio will invest primarily in the more established Asian markets,
including Hong Kong, Singapore, Malaysia, Thailand, the Philippines and
Indonesia. The Portfolio may also invest in common stocks traded on markets in
Taiwan, South Korea, India, Pakistan, Sri Lanka and other emerging markets that
are open to foreign investment. There is no requirement that the Portfolio, at
any given time, invest in any or all of the countries listed above or in any
other Asian countries. The Portfolio has no set policy for allocating
investments among the various Asian countries. Allocation of investments will
depend on the relative attractiveness of the stocks of issuers in the respective
countries. Government regulation and restrictions in many of the countries of
interest may limit the amount, mode and extent of investment in companies of
such countries.
 
    At least 65% of the total assets of the Portfolio will be invested in common
stocks of Asian countries under normal circumstances. The remaining portion of
the Portfolio will be kept in any combination of debt instruments, bills and
bonds of governmental entities in Asia and the United States, in notes,
debentures and bonds of companies in Asia and in money market instruments.
 
    The Adviser's approach in selecting investments for the Portfolio is
oriented to individual stock selection, and is value driven. In selecting stocks
for the Portfolio, the Adviser initially identifies those stocks which it
believes to be undervalued in relation to the issuer's assets, cash flow,
earnings and revenues, and then evaluates the future value of such stocks by
running the results of an in-depth study of the issuer through a dividend
discount model. The Adviser utilizes the research of a number of sources,
including Morgan Stanley Capital International, an affiliate of the Adviser
located in Geneva, Switzerland, in identifying attractive securities, and
applies a number of proprietary screening criteria to identify those securities
it believes to be undervalued. Portfolio holdings are regularly reviewed and
subjected to fundamental analysis to determine whether they continue to conform
to the Adviser's value criteria. Securities which no longer conform to such
value criteria are sold. The Adviser will analyze assets, revenues and earnings
of an issuer. In selecting industries and particular
 
                                       11
<PAGE>
issuers, the Adviser will evaluate costs of labor and raw materials, access to
technology, export of products and government regulation. Although the Portfolio
seeks to invest in larger companies, it may invest in medium-sized and small
companies that, in the Adviser's view, have potential for growth.
 
    The Portfolio's investments will include securities of issuers located in
emerging countries and traded in emerging markets. These securities pose greater
liquidity risks and other risks than securities of companies located in
developed countries and traded in more established markets. For a description of
special considerations and certain risks associated with investment in foreign
issuers, see "Additional Investment Information."
 
    Although the Portfolio intends to invest primarily in equity securities
listed on stock exchanges, it will also invest in equity securities traded in
over-the-counter markets and in Depositary Receipts. Securities traded in
over-the-counter markets pose liquidity risks. Pending investment or settlement,
and for liquidity purposes, the Portfolio may invest in domestic, Eurodollar and
foreign short-term money market instruments. The Portfolio may also invest in
initial public offerings in the form of oversubscriptions or private placements.
Such investments generally entail short-term liquidity risks.
 
THE JAPANESE EQUITY PORTFOLIO
 
    The investment objective of the Japanese Equity Portfolio is to provide
long-term capital appreciation. The Portfolio seeks to achieve this objective by
investing primarily in equity securities of Japanese issuers. Under normal
conditions, the Portfolio will invest at least 80% of its total assets in
securities of issuers that are organized under the laws of Japan, affiliates of
Japanese companies (wherever organized or traded) and issuers not organized
under the laws of Japan but deriving 50% or more of their revenues from Japan.
These securities may include debt securities (issued by the Japanese government
or by Japanese companies) when the Adviser believes that the potential for
capital appreciation from investment in debt securities equals or exceeds that
available from investment in equity securities. All debt securities in which the
Portfolio may invest will be rated no lower than BBB by Standard & Poor's
Ratings Group ("S&P"), Baa by Moody's Investors Service, Inc. ("Moody's") or BBB
by Mikuni Inc. ("Mikuni") (a Japanese rating agency) or, if unrated, of
comparable quality as determined by the Adviser. Securities rated BBB by S&P,
Baa by Moody's or BBB by Mikuni have speculative characteristics and changes in
economic conditions or other circumstances are more likely to lead to a weakened
capacity to make principal and interest payments on such securities than would
be the case with higher rated securities. The convertible securities in which
the Portfolio may invest include bonds, notes, debentures, preferred stocks and
other securities convertible into common stocks and may be fixed-income or zero
coupon debt securities. Prior to their conversion, convertible securities may
have characteristics similar to non-convertible debt securities.
 
    The Portfolio currently intends to focus its investments in Japanese
companies that have an active market for their shares and that the Adviser
believes show a potential for better than average growth. In making investment
decisions, the Adviser will consider, among other factors, the size of the
company, its financial condition, its marketing and technical strengths and its
competitiveness in its industry. The Portfolio anticipates that most equity
securities of Japanese companies in which it invests, either directly or
indirectly by means of Depositary Receipts or convertible debentures, will be
listed on securities exchanges in Japan. The Portfolio may also invest in equity
securities of Japanese companies that are traded in an over-the-counter market.
 
    RISK FACTORS RELATING TO JAPANESE EQUITY PORTFOLIO.  Investors should
consider the following factors inherent in investment in Japan.
 
                                       12
<PAGE>
    TRADE ISSUES.  Because of the concentration of Japanese exports in highly
visible products such as automobiles, machine tools and semiconductors, and the
large trade surpluses ensuing therefrom, Japan is in a difficult phase in its
relation with its trading partners, particularly the United States, where the
trade imbalance is the greatest. Retaliatory action taken by such trading
partners could affect the ability of Japanese companies to export goods to these
countries, which could negatively impact the value of securities in the
Portfolio.
 
    CURRENCY FACTORS.  Over time, the yen has generally appreciated in relation
to the U.S. dollar. The yen's appreciation would add to the returns of dollars
invested through the Portfolio in Japan. A decline in the value of the yen would
have the opposite effect, adversely affecting the value of the Portfolio in U.S.
dollar terms.
 
    THE JAPANESE STOCK MARKET.  Like other stock markets, the Japanese stock
market can be volatile. A decline in the market may have an adverse effect on
the availability of credit and on the value of the substantial stock holdings of
Japanese companies, in particular, Japanese banks, insurance companies and other
financial institutions. A decline in the market may contribute to weakness in
Japan's economy. The common stocks of many Japanese companies continue to trade
at high price-earnings ratios even after the recent market decline. Differences
in accounting methods make it difficult to compare the earnings of Japanese
companies with those of companies in other countries, especially the United
States. In general, however, reported net income in Japan is understated
relative to U.S. accounting standards. In addition, Japanese companies have
tended historically to have higher growth rates than U.S. companies, and
Japanese interest rates have generally been lower than in the United States,
both of which factors tend to result in lower discount rates and higher
price-earnings ratios in Japan than in the United States.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    DEPOSITARY RECEIPTS.  The Portfolios may invest in Depositary Receipts,
including American Depositary Receipts ("ADRs"), Global Depositary Receipts
("GDRs"), European Depositary Receipts ("EDRs") and other Depositary Receipts
(which, together with ADRs, GDRs and EDRs, are hereinafter collectively referred
to as "Depositary Receipts"), to the extent that such Depositary Receipts are or
become available. ADRs are securities, typically issued by a U.S. financial
institution (a "depositary"), that evidence ownership interests in a security or
a pool of securities issued by a foreign issuer (the "underlying issuer") and
deposited with the depositary. ADRs include American Depositary Shares and New
York Shares and may be "sponsored" or "unsponsored." Sponsored ADRs are
established jointly by a depositary and the underlying issuer, whereas
unsponsored ADRs may be established by a depositary without participation by the
underlying issuer. The issuers of the stock of unsponsored ADRs are not
obligated to disclose material information in the United States and therefore,
there may not be a correlation between such information and the market value of
the ADR. GDRs, EDRs and other types of Depositary Receipts are typically issued
by foreign depositaries, although they may also be issued by U.S. depositaries,
and evidence ownership interests in a security or pool of securities issued by
either a foreign or a U.S. corporation. Generally, Depositary Receipts in
registered form are designed for use in the U.S. securities market and
Depositary Receipts in bearer form are designed for use in securities markets
outside the United States. The Portfolios may invest in sponsored and
unsponsored Depositary Receipts. For purposes of the Portfolios' investment
policies, the Portfolios' investments in Depositary Receipts will be deemed to
be investments in the underlying securities.
 
    FOREIGN CURRENCY FORWARD CONTRACTS.  Each Portfolio may enter into foreign
currency forward contracts ("forward contracts") that provide for the purchase
or sale of an amount of a specified currency at a future date.
 
                                       13
<PAGE>
The Portfolios may use such contracts to protect against a decline in a foreign
currency against the U.S. dollar between the trade date and settlement date when
the Portfolio purchases or sells securities, lock in the U.S. dollar value of
dividends and interest on securities held by the Portfolio, and generally to
protect the U.S. dollar value of securities held by the Portfolio against
exchange rate fluctuation. While forward contracts may limit losses as a result
of exchange rate fluctuations, they will also limit any gains that might
otherwise have been realized. The Portfolio's Custodian may be required to place
cash or liquid securities in a segregated account in an amount equal to the
value of the Portfolio's total assets committed to the consummation of forward
contracts. If the value of the securities placed in the segregated account
declines, additional cash or securities will be placed in the account on a daily
basis so that the value of the account will be at least equal to the amount of
the Portfolio's commitments with respect to such contracts.
 
    FOREIGN INVESTMENT.  Investment in securities of foreign issuers involves
somewhat different investment risks than those affecting securities of U.S.
domestic issuers. There may be limited publicly available information with
respect to foreign issuers, and foreign issuers are not generally subject to
uniform accounting, auditing and financial and other reporting standards and
requirements comparable to those applicable to U.S. companies. There may also be
less government supervision and regulation of foreign securities exchanges,
brokers and listed companies than in the United States. Many foreign securities
markets have substantially less volume than U.S. national securities exchanges,
and securities of some foreign issuers are less liquid and more volatile than
securities of comparable domestic issuers. Brokerage commissions and other
transaction costs on foreign securities exchanges are generally higher than in
the United States. Dividends and interest paid by foreign issuers may be subject
to withholding and other foreign taxes, which may decrease the net return on
foreign investments as compared to dividends and interest paid to the Portfolios
by domestic companies, and it is not expected that a Portfolio or its
shareholders would be able to claim a credit for U.S. tax purposes with respect
to any such foreign taxes. Additional risks include future political and
economic developments, the possibility that a foreign jurisdiction might impose
or change withholding taxes on income payable with respect to foreign
securities, possible seizure, nationalization or expropriation of the foreign
issuer or foreign deposits and the possible adoption of foreign governmental
restrictions such as exchange controls. Many of the emerging countries may have
less stable political environments than more developed countries. Also, it may
be more difficult to obtain a judgment in a court outside the United States.
 
    Investments in securities of foreign issuers are frequently denominated in
foreign currencies, and the Portfolios may temporarily hold uninvested reserves
in bank deposits in foreign currencies. Therefore, the value of each Portfolio's
assets as measured in U.S. dollars may be affected favorably or unfavorably by
changes in currency rates and in exchange control regulations, and the
Portfolios may incur costs in connection with conversions between various
currencies.
 
    The Asian Equity Portfolio may invest in securities of issuers located in
Hong Kong. Hong Kong was established as a British colony in the 1840's and,
until recently, was ruled by the British Government through an appointed
Governor. Effective July 1, 1997, Hong Kong reverted to Chinese sovereignty and
is governed as a Special Administrative Region of China. Although China has made
certain commitments to preserve the economic and social freedoms enjoyed in Hong
Kong during British rule, there can be no assurances China's commitments will be
maintained. Action taken by the Chinese government which limits or causes
uncertainty with regard to these economic and social freedoms could have an
adverse affect on the Portfolio's investments in securities of issuers located
in Hong Kong.
 
                                       14
<PAGE>
    LOANS OF PORTFOLIO SECURITIES.  Each Portfolio may lend its securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing its net investment income. These loans must be secured
continuously by cash or equivalent collateral or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be risks of delay in recovery of the securities or even loss
of rights in the collateral should the borrower of the securities fail
financially. A Portfolio will not enter into securities loan transactions
exceeding in the aggregate 33 1/3% of the market value of the Portfolio's total
assets.
 
    MONEY MARKET INSTRUMENTS.  The Portfolios are permitted to invest in money
market instruments, although each Portfolio intends to stay invested in
securities satisfying its primary investment objective to the extent practical.
Consistent with their investment policies, each Portfolio may make money market
investments pending other investment or settlement for liquidity. In addition,
the Portfolios may invest in money market instruments for temporary defensive
purposes during adverse market conditions. See "Temporary Investments." The
money market investments permitted for the Portfolios include obligations of the
U.S. Government and its agencies and instrumentalities; obligations of foreign
sovereignties; other debt securities; commercial paper; bank obligations;
certificates of deposit (including Eurodollar certificates of deposit); and
repurchase agreements.
 
    NON-PUBLICLY TRADED SECURITIES, PRIVATE PLACEMENTS AND RESTRICTED
SECURITIES.  The Asian Equity Portfolio may invest in securities that are
neither listed on a stock exchange nor traded over-the-counter, including
privately placed securities. Such unlisted equity securities may involve a
higher degree of business and financial risk that can result in substantial
losses. As a result of the absence of a public trading market for these
securities, they may be less liquid than publicly traded securities. Although
these securities may be resold in privately negotiated transactions, the prices
realized from these sales could be less than those originally paid by the
Portfolio or less than what may be considered the fair value of such securities.
Further, companies whose securities are not publicly traded may not be subject
to the disclosure and other investor protection requirements which might be
applicable if their securities were publicly traded. If such securities are
required to be registered under the securities laws of one or more jurisdictions
before being resold, the Portfolio may be required to bear the expenses of
registration.
 
    As a general matter, the Portfolio may not invest more than 15% of its net
assets in illiquid securities, including securities for which there is no
readily available secondary market. Nor as a general matter, may the Portfolio
invest more than 10% of its total assets in securities that are restricted from
sale to the public without registration ("Restricted Securities") under the
Securities Act of 1933, as amended (the "1933 Act"). However, the Portfolio may
invest up to 25% of its total assets in liquid Restricted Securities that can be
offered and sold to qualified institutional buyers under Rule 144A under the
1933 Act ("Rule 144A Securities"). The Board of Directors has adopted guidelines
and delegated to the Adviser, subject to the supervision of the Board of
Directors, the daily function of determining and monitoring the liquidity of
Rule 144A Securities. Rule 144A Securities may become illiquid if qualified
institutional buyers are not interested in acquiring the securities.
 
    REPURCHASE AGREEMENTS.  Each Portfolio may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines established by
the Fund's Board of Directors. In a repurchase agreement, the Portfolio buys a
security from a seller that has agreed to repurchase it at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of the
agreement. The term of these agreements is usually from overnight to one week
and never exceeds one year. Repurchase agreements may be viewed as a fully
 
                                       15
<PAGE>
collateralized loan of money by the Portfolio to the seller. The Portfolio
always receives securities with a market value at least equal to the purchase
price (including accrued interest) as collateral, and this value is maintained
during the term of the agreement. If the seller defaults and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with respect to the seller, the Portfolio's realization upon the
collateral may be delayed or limited. The Portfolio may not enter into
repurchase agreements with more than seven days to maturity if, as a result,
more than 15% of the market value of the Portfolio's net assets are invested in
these agreements and other investments for which market quotations are not
readily available or which are otherwise illiquid.
 
    TEMPORARY INVESTMENTS.  For temporary defensive purposes, when the Adviser
determines that market conditions warrant, each Portfolio may invest up to 100%
of its assets in dollar and non-dollar denominated money market instruments and
short- and medium-term debt securities that the Adviser believes to be of high
quality, or hold cash. The short- and medium-term debt securities in which a
Portfolio may invest consist of (a) obligations of the U.S. or foreign country
governments, their respective agencies or instrumentalities; (b) bank deposits
and bank obligations (including certificates of deposit, time deposits and
bankers' acceptances) of U.S. or foreign country banks denominated in any
currency; (c) floating rate securities and other instruments denominated in any
currency issued by international development agencies; (d) finance company and
corporate commercial paper and other short-term corporate debt obligations of
U.S. and foreign country corporations meeting the Portfolio's credit quality
standards; and (e) repurchase agreements with banks and broker-dealers with
respect to such securities.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  Each Portfolio may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Delivery of and payment for these securities may take
as long as a month or more after the date of the purchase commitment but will
take place no more than 120 days after the trade date. Each Portfolio will
maintain with the Custodian a separate account with a segregated portfolio of
cash or liquid securities in an amount at least equal to these commitments. The
payment obligation and the interest rates that will be received are each fixed
at the time a Portfolio enters into the commitment and no interest accrues to
the Portfolio until settlement. Thus, it is possible that the market value at
the time of settlement could be higher or lower than the purchase price if,
among other factors, the general level of interest rates has changed. It is a
current policy of each Portfolio not to enter into when-issued commitments or
delayed delivery securities exceeding in the aggregate 15% of the market value
of the Portfolio's total assets less liabilities, other than the obligations
created by these commitments.
 
DERIVATIVE INSTRUMENTS
 
    The Portfolios are permitted to invest in various derivative instruments for
both hedging and non-hedging purposes. Derivative instruments include options,
futures and options on futures, structured investments and structured notes,
caps, floors, collars and swaps. Additionally, the Portfolios may invest in
other derivative instruments that are developed over time if their use would be
consistent with the objectives of the Portfolios. Each Portfolio will limit its
use of derivative instruments to 33 1/3% of its total assets measured by the
aggregate notional amount of outstanding derivative instruments. The Portfolios'
investments in forward foreign currency contracts and derivatives used for
hedging purposes are not subject to the limit described above.
 
                                       16
<PAGE>
    The Portfolios may use derivative instruments under a number of different
circumstances to further their investment objectives. The Portfolios may use
derivatives when doing so provides more liquidity than the direct purchase of
the securities underlying such derivatives. For example, a Portfolio may
purchase derivatives to quickly gain exposure to a market in response to changes
in the Portfolio's investment strategy or upon the inflow of investable cash
when the derivative provides greater liquidity than the underlying securities
market. A Portfolio may also use derivatives when it is restricted from directly
owning the underlying securities due to foreign investment restrictions or other
reasons or when doing so provides a price advantage over purchasing the
underlying securities directly, either because of a pricing differential between
the derivatives and securities markets or because of lower transaction costs
associated with the derivatives transaction. Derivatives may also be used by a
Portfolio for hedging purposes and in other circumstances in which a Portfolio's
portfolio managers believe it advantageous to do so consistent with the
Portfolio's investment objective. The Portfolios will not, however, use
derivatives in a manner that creates leverage, except to the extent that the use
of leverage is expressly permitted by a particular Portfolio's investment
policies, and then only in a manner consistent with such policies.
 
    Some of the derivative instruments in which the Portfolios may invest and
the risks related thereto are described in more detail below.
 
CAPS, FLOORS AND COLLARS
 
    The Portfolios may invest in caps, floors and collars, which are instruments
analogous to options. In particular, a cap is the right to receive the excess of
a reference rate over a given rate and is analogous to a put option. A floor is
the right to receive the excess of a given rate over a reference rate and is
analogous to a call option. Finally, a collar is an instrument that combines a
cap and a floor. That is, the buyer of a collar buys a cap and writes a floor,
and the writer of a collar writes a cap and buys a floor. The risks associated
with caps, floors and collars are similar to those associated with options. In
addition, caps, floors and collars are subject to risk of default by the
counterparty because they are privately negotiated instruments.
 
FUTURES CONTRACTS AND OPTIONS ON FUTURES CONTRACTS
 
    The Portfolios may purchase and sell futures contracts and options on
futures contracts, including but not limited to securities index futures,
foreign currency exchange futures, interest rate futures and other financial
futures. Futures contracts provide for the sale by one party and purchase by
another party of a specified amount of a specific security, instrument or basket
thereof, at a specific future date and at a specified price. An option on a
futures contract is a legal contract that gives the holder the right to buy or
sell a specified amount of futures contracts at a fixed or determinable price
upon the exercise of the option.
 
    The Portfolios may sell securities index futures contracts and/or options
thereon in anticipation of or during a market decline to attempt to offset the
decrease in market value of investments in its portfolio, or purchase securities
index futures in order to gain market exposure. Subject to applicable laws, the
Portfolios may engage in transactions in securities index futures contracts (and
options thereon) which are traded on a recognized securities or futures
exchange, or may purchase or sell such instruments in the over-the-counter
market. There currently are limited securities index futures and options on such
futures in many countries, particularly emerging countries. The nature of the
strategies adopted by the Adviser, and the extent to which those strategies are
used, may depend on the development of such markets.
 
                                       17
<PAGE>
    The Portfolios may engage in transactions involving foreign currency
exchange futures contracts. Such contracts involve an obligation to purchase or
sell a specific currency at a specified future date and at a specified price.
The Portfolios may engage in such transactions to hedge their respective
holdings and commitments against changes in the level of future currency rates
or to adjust their exposure to a particular currency.
 
    The Portfolios may engage in transactions in interest rate futures
transactions. Interest rate futures contracts involve an obligation to purchase
or sell a specific debt security, instrument or basket thereof at a specified
future date at a specified price. The value of the contract rises and falls
inversely with changes in interest rates. The Portfolios may engage in such
transactions to hedge their holdings of debt instruments against future changes
in interest rates.
 
    Financial futures are futures contracts relating to financial instruments,
such as U.S. Government securities, foreign currencies, and certificates of
deposit. Such contracts involve an obligation to purchase or sell a specific
security, instrument or basket thereof at a specified future date at a specified
price. Like interest rate futures contracts, the value of financial futures
contracts rises and falls inversely with changes in interest rates. The
Portfolios may engage in financial futures contracts for hedging and non-hedging
purposes.
 
    Under rules adopted by the Commodity Futures Trading Commission, each
Portfolio may enter into futures contracts and options thereon for both hedging
and non-hedging purposes, provided that not more than 5% of such Portfolio's
total assets at the time of entering the transaction are required as margin and
option premiums to secure obligations under such contracts relating to
non-hedging activities.
 
    Gains and losses on futures contracts and options thereon depend on the
Adviser's ability to predict correctly the direction of securities prices,
interest rates and other economic factors. Other risks associated with the use
of futures and options are (i) imperfect correlation between the change in
market value of investments held by a Portfolio and the prices of futures and
options relating to investments purchased or sold by the Portfolio, and (ii)
possible lack of a liquid secondary market for a futures contract and the
resulting inability to close a futures position. The risk that a Portfolio will
be unable to close out a futures position or options contract will be minimized
by only entering into futures contracts or options transactions for which there
appears to be a liquid exchange or secondary market. The risk of loss in trading
on futures contracts in some strategies can be substantial, due both to the low
margin deposits required and the extremely high degree of leverage involved in
futures pricing.
 
OPTIONS TRANSACTIONS
 
    The Portfolios may seek to increase their returns or may hedge their
portfolio investments through options transactions with respect to securities,
instruments, indices or baskets thereof in which such Portfolios may invest, as
well as with respect to foreign currency. Purchasing a put option gives a
Portfolio the right to sell a specified security, currency or basket of
securities or currencies at the exercise price until the expiration of the
option. Purchasing a call option gives a Portfolio the right to purchase a
specified security, currency or basket of securities or currencies at the
exercise price until the expiration of the option.
 
    Each Portfolio also may write (i.e., sell) put and call options on
investments held in its portfolio, as well as with respect to foreign currency.
A Portfolio that has written an option receives a premium, which increases the
Portfolio's return on the underlying security or instrument in the event the
option expires unexercised or is closed out at a profit. However, by writing a
call option, a Portfolio will limit its opportunity to profit from an
 
                                       18
<PAGE>
increase in the market value of the underlying security or instrument above the
exercise price of the option for as long as the Portfolio's obligation as writer
of the option continues. The Portfolios may only write options that are
"covered." A covered call option means that so long as the Portfolio is
obligated as the writer of the option, it will earmark or segregate sufficient
liquid assets to cover its obligations under the option or own (i) the
underlying security or instrument subject to the option, (ii) securities or
instruments convertible or exchangeable without the payment of any consideration
into the security or instrument subject to the option, or (iii) a call option on
the same underlying security with a strike price no higher than the price at
which the underlying instrument was sold pursuant to a short option position.
 
    By writing (or selling) a put option, a Portfolio incurs an obligation to
buy the security or instrument underlying the option from the purchaser of the
put at the option's exercise price at any time during the option period, at the
purchaser's election. The Portfolios may also write options that may be
exercised by the purchaser only on a specific date. A Portfolio that has written
a put option will earmark or segregate sufficient liquid assets to cover its
obligations under the option or will own a put option on the same underlying
security with an equal or higher strike price.
 
    The Portfolios may engage in transactions in options which are traded on
recognized exchanges or over-the-counter. There currently are limited options
markets in many countries, particularly emerging countries such as Latin
American countries, and the nature of the strategies adopted by the Adviser and
the extent to which those strategies are used will depend on the development of
such options markets. The primary risks associated with the use of options are
(i) imperfect correlation between the change in market value of investments
held, purchased or sold by a Portfolio and the prices of options relating to
such investments, and (ii) possible lack of a liquid secondary market for an
option.
 
STRUCTURED NOTES
 
    Structured Notes are derivatives on which the amount of principal repayment
and/or interest payments is based upon the movement of one or more factors.
These factors include, but are not limited to, currency exchange rates, interest
rates (such as the prime lending rate and LIBOR) and stock indices such as the
S&P 500 Index. In some cases, the impact of the movements of these factors may
increase or decrease through the use of multipliers or deflators. The Portfolios
may use structured notes to tailor their investments to the specific risks and
returns the Adviser wishes to accept while avoiding or reducing certain other
risks.
 
SWAPS -- SWAP CONTRACTS
 
    Swaps and Swap Contracts are derivatives in the form of a contract or other
similar instrument in which two parties agree to exchange the returns generated
by a security, instrument, basket or index thereof for the returns generated by
another security, instrument, basket thereof or index. The payment streams are
calculated by reference to a specific security, index or instrument and an
agreed upon notional amount. The relevant indices include but are not limited
to, currencies, fixed interest rates, prices and total return on interest rate
indices, fixed income indices, stock indices and commodity indices (as well as
amounts derived from arithmetic operations on these indices). For example, a
Portfolio may agree to swap the return generated by a fixed income index for the
return generated by a second fixed income index. The currency swaps in which the
Portfolios may enter will generally involve an agreement to pay interest streams
in one currency based on a specified index in exchange for receiving interest
streams denominated in another currency. Such swaps may involve initial and
final exchanges that correspond to the agreed upon notional amount.
 
                                       19
<PAGE>
    A Portfolio will usually enter into swaps on a net basis, i.e., the two
return streams are netted out in a cash settlement on the payment date or dates
specified in the instrument, with a Portfolio receiving or paying, as the case
may be, only the net amount of the two returns. A Portfolio's obligations under
a swap agreement will be accrued daily (offset against any amounts owing to the
Portfolio) and any accrued, but unpaid, net amounts owed to a swap counterparty
will be covered by the maintenance of a segregated account consisting of cash or
liquid securities. A Portfolio will not enter into any swap agreement unless the
counterparty meets the rating requirements set forth in guidelines established
by the Fund's Board of Directors.
 
    Interest rate and total rate of return swaps do not involve the delivery of
securities, other underlying assets, or principal. Accordingly, the risk of loss
with respect to interest rate and total rate of return swaps is limited to the
net amount of payments that a Portfolio is contractually obligated to make. If
the other party to an interest rate or total rate of return swap defaults, a
Portfolio's risk of loss consists of the net amount of payments that a Portfolio
is contractually entitled to receive. In contrast, currency swaps may involve
the delivery of the entire principal value of one designated currency in
exchange for the other designated currency. Therefore, the entire principal
value of a currency swap may be subject to the risk that the other party to the
swap will default on its contractual delivery obligations. If there is a default
by the counterparty, a Portfolio may have contractual remedies pursuant to the
agreements related to the transaction. The swaps market has grown substantially
in recent years with a large number of banks and investment banking firms acting
both as principals and as agents utilizing standardized swap documentation. As a
result, the swaps market has become relatively liquid. Swaps that include caps,
floors and collars are more recent innovations for which standardized
documentation has not yet been fully developed and, accordingly, they are less
liquid than "traditional" swaps.
 
    The use of swaps is a highly specialized activity which involves investment
techniques and risks different from those associated with ordinary portfolio
securities transactions. If the Adviser is incorrect in its forecasts of market
values, interest rates, and currency exchange rates, the investment performance
of the Portfolios would be less favorable than it would have been if this
investment technique were not used.
 
                             INVESTMENT LIMITATIONS
 
    Each Portfolio is a diversified investment company under the Investment
Company Act of 1940, as amended (the "1940 Act") and is therefore subject to the
following limitations: (a) as to 75% of its total assets, a Portfolio may not
invest more than 5% of its total assets in the securities of any one issuer,
except obligations of the U.S. Government and its agencies and
instrumentalities, and (b) a Portfolio may not own more than 10% of the
outstanding voting securities of any one issuer.
 
    Each Portfolio also operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of the
holders of a majority of such Portfolio's outstanding shares and under certain
non-fundamental investment limitations that may be changed without shareholder
approval. For additional information on fundamental and non-fundamental
investment limitations, see "Investment Limitations" in the Statement of
Additional Information.
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and each Portfolio. The Adviser provides investment
advice and portfolio management services, pursuant
 
                                       20
<PAGE>
to an Investment Advisory Agreement and, subject to the supervision of the
Fund's Board of Directors, makes each of the Portfolio's day-to-day investment
decisions, arranges for the execution of portfolio transactions and generally
manages each of the Portfolio's investments. Set forth below as an annual
percentage of average daily net assets are the management fees payable to the
Adviser quarterly by each Portfolio pursuant to the terms of the Investment
Advisory Agreement. The Adviser has agreed to a reduction in the fees payable to
it and to reimburse the Portfolios, if necessary, if such fees would cause total
annual operating expenses of the Portfolios to exceed the maximums set forth in
the table below.
 
<TABLE>
<CAPTION>
                                                                    MAXIMUM TOTAL ANNUAL
                                                                         OPERATING
                                              MANAGEMENT FEES    EXPENSES AFTER FEE WAIVERS
                                                ABSENT FEE       --------------------------
PORTFOLIO                                         WAIVERS          CLASS A       CLASS B
- ------------------------------------------  -------------------  ------------  ------------
<S>                                         <C>                  <C>           <C>
Asian Equity                                         0.80%             1.00%         1.25%
Japanese Equity                                      0.80%             1.00%         1.25%
</TABLE>
 
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to customers in the
United States and abroad. The Adviser and Morgan Stanley are subsidiaries of
Morgan Stanley, Dean Witter, Discover & Co. At August 31, 1997, the Adviser
(exclusive of Miller Anderson & Sherrerd, LLP, Van Kampen American Capital, Inc.
and Dean Witter InterCapital Inc.) managed assets of approximately $80.9
billion. See "Management of the Fund" in the Statement of Additional
Information.
 
    PORTFOLIO MANAGERS.  The following individuals have primary portfolio
management responsibility for the Portfolios noted below:
 
    ASIAN EQUITY PORTFOLIO -- EAN WAH CHIN.  Ean Wah Chin is a Managing Director
of Morgan Stanley, and is responsible for the Adviser's regional Asia ex-Japan
operations based in Singapore. She has been primarily responsible for managing
the Portfolio's assets since its inception. Prior to joining Morgan Stanley in
1986, Ms. Chin spent eight years with the Monetary Authority of Singapore and
the Government of Singapore Investment Corporation, where she was a portfolio
manager of one of the largest portfolios in Asia. Ms. Chin was an ASEAN scholar
educated at the University of Singapore.
 
    JAPANESE EQUITY PORTFOLIO -- JOHN R. ALKIRE AND KUNIHIKO SUGIO. John R.
Alkire is a Managing Director of Morgan Stanley. He has been primarily
responsible for managing the Portfolio's assets since June 1997. Mr. Alkire
joined the Adviser in 1981 to initiate foreign equity sales and trading to
Pacific basin institutions. He was appointed President of Morgan Stanley
Investment Advisory, Japan in October 1993. Prior to 1993, he specialized in
Japanese warrants and cash equity sales and trading to Japanese financial
institutions in the Tokyo office. Mr. Alkire is a graduate of University of
Victoria Canada. Kunihiko Sugio, a Principal of Morgan Stanley, joined the
Adviser in December 1993 and manages dedicated Japanese equity portfolios. He
has been primarily responsible for managing the Portfolio's assets since its
inception. Prior to joining Morgan Stanley, he worked with Baring International
Investment Management, Tokyo, where he was a Director and fund manager. He
graduated from Wakayama Kokuritsu University.
 
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the Officers and
Board of Directors of the Fund and include day-to-day administration of matters
related to the
 
                                       21
<PAGE>
corporate existence of the Fund, maintenance of its records, preparation of
reports, supervision of the Fund's arrangements with its custodian and
assistance in the preparation of the Fund's registration statements under
federal laws. The Administration Agreement also provides that the Administrator,
through its agents, will provide dividend disbursing and transfer agent services
to the Fund. For its services under the Administration Agreement, the Fund pays
the Adviser a monthly fee which on an annual basis equals 0.15% of the average
daily net assets of each Portfolio.
 
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors such administrative services provided by CGFSC.
Their services are also subject to the supervision of the Board of Directors of
the Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of each Portfolio upon the terms and at the current
offering price described in this Prospectus. Morgan Stanley is not obligated to
sell any certain number of shares of any Portfolio.
 
    The Portfolios currently offer only the classes of shares offered by this
Prospectus. The Portfolios may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares of each Multiclass Portfolio pursuant to Rule 12b-1 under the 1940 Act
(each, a "Plan"). Under each Plan, the Distributor is entitled to receive from
each Multiclass Portfolio a distribution fee, which is accrued daily and paid
quarterly, of 0.25% of the Class B shares' average daily net assets on an
annualized basis. The Distributor expects to reallocate most of its fee to its
investment representatives. The Distributor may, in its discretion, voluntarily
waive from time to time all or any portion of its distribution fee and each of
the Distributor and the Adviser is free to make additional payments out of its
own assets to promote the sale of Fund shares, including payments that
compensate financial institutions for distribution services or shareholder
services.
 
    Each Plan is designed to compensate the Distributor for its services, not to
reimburse the Distributor for its expenses, and the Distributor may retain any
portion of the fee that it does not expend in fulfillment of its obligations to
the Fund.
 
    EXPENSES.  Each Portfolio is responsible for payment of certain other fees
and expenses (including legal fees, accountant's fees, custodial fees and
printing and mailing costs) specified in the Administration and Distribution
Agreements.
 
                               PURCHASE OF SHARES
 
    Class A shares of each Portfolio and Class B shares of each Multiclass
Portfolio may be purchased at the net asset value per share next determined
after receipt of the purchase order by the Portfolio. See "Valuation of
 
                                       22
<PAGE>
Shares." Shareholders of the International Small Cap Portfolio may be charged a
1.00% transaction fee, which is payable directly to the International Small Cap
Portfolio, in connection with each purchase and redemption of shares of the
Portfolio. The transaction fee is intended to allocate transaction costs
associated with purchases and redemptions of shares of the Portfolio to
investors actually making such purchases and redemptions rather than to the
Portfolio's other shareholders. The 1.00% fee represents the Adviser's estimate
of such transaction costs, which include the costs of acquiring and disposing of
Portfolio securities. The transaction fee is not a sales charge or load, and is
retained by the Portfolio. The fee does not apply to Portfolios of the Fund
other than the International Small Cap Portfolio and is not charged in
connection with the reinvestment of dividends or capital gain distributions. The
fee will not be charged with respect to purchases and redemptions that do not
result in actual transaction costs to the Portfolio.
 
MINIMUM INVESTMENT AND ACCOUNT SIZES; CONVERSION FROM CLASS A TO CLASS B SHARES
 
    For a Portfolio account opened on or after January 2, 1996 (a "New
Account"), the minimum initial investment and minimum account size are $500,000
for Class A shares and $100,000 for Class B shares of each Portfolio. Certain
advisory or asset allocation accounts, such as Total Funds Management accounts,
managed by Morgan Stanley or its affiliates, including the Adviser ("Managed
Accounts") may purchase Class A shares without being subject to such minimum
initial investment or minimum account size requirements for a Portfolio account.
Employees of the Adviser and certain of its affiliates may purchase Class A
shares subject to conditions, including a lower minimum initial investment,
established by Officers of the Fund.
 
    If the value of a New Account containing Class A shares falls below $500,000
(but remains at or above $100,000) because of shareholder redemption(s), the
Fund will notify the shareholder, and if the account value remains below
$500,000 (but remains at or above $100,000) for a continuous 60-day period, the
Class A shares in such account will convert to Class B shares and will be
subject to the distribution fee and other features applicable to the Class B
shares. The Fund, however, will not convert Class A shares to Class B shares
based solely upon changes in the market that reduce the net asset value of
shares. Under current tax law, conversions between share classes are not a
taxable event to the shareholder.
 
    Shares in a Portfolio account opened prior to January 2, 1996 (a "Pre-1996
Account") were designated Class A shares on January 2, 1996. Shares in a
Pre-1996 Account with a value of $100,000 or more on March 1, 1996 (a
"Grandfathered Class A Account") remained Class A shares regardless of account
size thereafter. Except for shares in a Managed Account, shares in a Pre-1996
Account with a value of less than $100,000 on March 1, 1996 (a "Grandfathered
Class B Account") converted to Class B shares on March 1, 1996. Grandfathered
Class A Accounts and Managed Accounts are not subject to conversion from Class A
shares to Class B shares.
 
    Investors may also invest in the Fund by purchasing shares through a trust
department, broker, dealer, agent, financial planner, financial services firm or
investment adviser. An investor may be charged an additional service or
transaction fee by that institution.
 
    The minimum investment levels may be waived at the discretion of the Adviser
for (i) certain employees and customers of Morgan Stanley or its affiliates and
certain trust departments, brokers, dealers, agents, financial planners,
financial services firms, or investment advisers that have entered into an
agreement with Morgan Stanley or its affiliates; and (ii) retirement and
deferred compensation plans and trusts used to fund such
 
                                       23
<PAGE>
plans, including, but not limited to, those defined in Section 401(a), 403(b) or
457 of the Code and "rabbi trusts." The Fund reserves the right to modify or
terminate the conversion features of the shares as stated above at any time upon
60-days notice to shareholders.
 
    The Adviser reserves the right in its sole discretion to determine which of
such advisory or asset allocation accounts shall be Managed Accounts. For
information regarding Managed Accounts, please contact your Morgan Stanley
account representative or the Fund at the telephone number provided on the cover
of this Prospectus.
 
MINIMUM ACCOUNT SIZES AND INVOLUNTARY REDEMPTION OF SHARES
 
    If the value of a New Multiclass Account falls below $100,000 because of
shareholder redemption(s), the Fund will notify the shareholder, and if the
account value remains below $100,000 for a continuous 60-day period, the shares
in such account are subject to redemption by the Fund and, if redeemed, the net
asset value of such shares will be promptly paid to the shareholder. The Fund,
however, will not redeem shares based solely upon changes in the market that
reduce the net asset value of shares.
 
    Grandfathered Class A Accounts, Grandfathered Class B Accounts and Managed
Accounts are not subject to involuntary redemption. If a shareholder reduces its
total investment in Class A shares of the International Small Cap Portfolio to
less than $500,000, the investment may be subject to redemption. The Fund
reserves the right to modify or terminate the involuntary redemption features of
the shares as stated above at any time upon 60-days notice to shareholders.
 
CONVERSION FROM CLASS B TO CLASS A SHARES
 
    If the value of Class B shares in a Multiclass Portfolio account increases,
whether due to shareholder share purchases or market activity, to $500,000 or
more, the Class B shares will convert to Class A shares. Under current tax law,
such conversion is not a taxable event to the shareholder. Class A shares
converted from Class B shares are subject to the same minimum account size
requirements that are applicable to New Multiclass Accounts containing Class A
shares, as stated above. The Fund reserves the right to modify or terminate this
conversion feature at any time upon 60-days notice to shareholders.
 
INITIAL PURCHASES DIRECTLY FROM THE FUND
 
    The Fund's determination of an investor's eligibility to purchase shares of
a given class will take precedence over the investor's selection of a class.
 
1) BY CHECK.  An account may be opened by completing and signing an Account
   Registration Form and mailing it, together with a check ($500,000 minimum for
   Class A shares of each Portfolio and $100,000 minimum for Class B shares of
   each Multiclass Portfolio, with certain exceptions for Morgan Stanley
   employees and select customers) payable to "Morgan Stanley Institutional
   Fund, Inc. -- [portfolio name]", to:
 
      Morgan Stanley Institutional Fund, Inc.
      P.O. Box 2798
      Boston, Massachusetts 02208-2798
 
Payment will be accepted only in U.S. dollars, unless prior approval for payment
in other currencies is given by the Fund. The classes of shares of the
Portfolio(s) to be purchased should be designated on the Account Registration
 
                                       24
<PAGE>
Form. For purchases by check, the Fund is ordinarily credited with Federal Funds
within one business day. Thus, your purchase of shares by check is ordinarily
credited to your account at the net asset value per share of the relevant
Portfolio determined on the next business day after receipt.
 
2) BY FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire
   Federal Funds to the Fund's bank account. In order to ensure prompt receipt
   of your Federal Funds Wire, it is important that you follow these steps:
 
A.  Telephone the Fund (toll free: 1-800-548-7786) and provide us with your
    name, address, telephone number, Social Security or Tax Identification
    Number, the portfolio(s) selected, the class selected, the amount being
    wired, and by which bank. We will then provide you with a Fund account
    number. (Investors with existing accounts should also notify the Fund prior
    to wiring funds.)
 
B.  Instruct your bank to wire the specified amount to the Fund's Wire
    Concentration Bank Account (be sure to have your bank include the name of
    the portfolio(s) selected, the class selected, and the account number
    assigned to you) as follows:
 
    The Chase Manhattan Bank
    One Manhattan Plaza
    New York, NY 10081-1000
    ABA #021000021
    DDA #910-2-733293
    Attn: Morgan Stanley Institutional Fund, Inc.
    Ref: (Portfolio name, your account number, your account name)
 
    Please call the Fund at 1-800-548-7786 prior to wiring funds.
 
C.  Complete and sign the Account Registration Form and mail it to the address
    shown thereon.
 
  The purchase price of the Class A and Class B shares of each Portfolio is the
  net asset value next determined after the order is received. See "Valuation of
  Shares." An order received prior to the regular close of the New York Stock
  Exchange ("NYSE"), which is currently 4:00 p.m. Eastern Time, will be executed
  at the price computed on the date of receipt; an order received after the
  regular close of the NYSE will be executed at the price computed on the next
  day the NYSE is open as long as the Transfer Agent receives payment by check
  or in Federal Funds prior to the regular close of the NYSE on such day.
 
  Federal Funds purchase orders will be accepted only on a day on which the Fund
  and Chase (the "Custodian Bank") are open for business. Your bank may charge a
  service fee for wiring Federal Funds.
 
3) BY BANK WIRE.  The same procedure outlined under "By Federal Funds Wire"
   above must be followed in purchasing shares by bank wire. However, money
   transferred by bank wire may or may not be converted into Federal Funds the
   same day, depending on the time the money is received and the bank handling
   the wire. Prior to such conversion, an investor's money will not be invested
   and, therefore, will not be earning dividends. Your bank may charge a service
   fee for wiring funds.
 
                                       25
<PAGE>
ADDITIONAL INVESTMENTS
 
    You may add to your account at any time (minimum additional investment
$1,000 for each portfolio, except for automatic reinvestment of dividends and
capital gains distributions for which there are no minimums) by purchasing
shares at net asset value by mailing a check to the Fund (payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio name]") at the above address or
by wiring monies to the Custodian Bank as outlined above. It is very important
that your account name, the portfolio name and the class selected be specified
in the letter or wire to assure proper crediting to your account. In order to
ensure that your wire orders are invested promptly, you are requested to notify
one of the Fund's representatives (toll-free 1-800-548-7786) prior to the wire
date. Additional investments will be applied to purchase additional shares in
the same class held by a shareholder in a Portfolio account.
 
OTHER PURCHASE INFORMATION
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends. The net asset value of Class B shares will generally be
lower than the net asset value of Class A shares as a result of the distribution
expense charged to Class B shares. It is expected, however, that the net asset
value per share of the two classes will tend to converge immediately after the
recording of dividends which will differ by approximately the amount of the
distribution expense accrual differential between the classes.
 
    In the interest of economy and convenience, and because of the operating
procedures of the Fund, certificates representing shares of the Portfolio(s)
will not be issued. All shares purchased are confirmed to you and credited to
your account on the Fund's books maintained by the Adviser or its agents. You
will have the same rights and ownership with respect to such shares as if
certificates had been issued.
 
    To ensure that checks are collected by the Fund, withdrawals of investments
made by check are not presently permitted until payment for the purchase has
been received, which may take up to eight business days after the date of
purchase. As a condition of this offering, if a purchase is cancelled due to
nonpayment or because your check does not clear, you will be responsible for any
loss the Fund or its agents incur. If you are already a shareholder, the Fund
may redeem shares from your account(s) to reimburse the Fund or its agents for
any loss. In addition, you may be prohibited or restricted from making future
investments in the Fund.
 
    Investors may also invest in the Fund by purchasing shares through the
Distributor.
 
EXCESSIVE TRADING
 
    Frequent trades involving either substantial portfolio assets or a
substantial portion of your account or accounts controlled by you can disrupt
management of a Portfolio and raise its expenses. Consequently, in the interest
of all the stockholders of the Portfolios and the Portfolios' performance, the
Fund may in its discretion bar a stockholder that engages in excessive trading
of shares of any class of a portfolio from further purchases of shares of the
Fund for an indefinite period. The Fund considers excessive trading to be more
than one purchase and sale involving shares of the same class of a Portfolio of
the Fund within any 120-day period. As an example, exchanging shares of
portfolios of the Fund as follows amounts to excessive trading: exchanging
shares of Portfolio A for shares of Portfolio B, then exchanging shares of
Portfolio B for shares of Portfolio C and again exchanging shares of Portfolio C
for shares of Portfolio B within a 120-day period. Two types of transactions are
 
                                       26
<PAGE>
exempt from these excessive trading restrictions: (1) trades exclusively between
money market portfolios; and (2) trades done in connection with an asset
allocation service, such as TFM Accounts or accounts managed or advised by the
Adviser and/or any of its affiliates.
 
INVESTMENT IN FUNDS THROUGH A TOTAL FUNDS MANAGEMENT ("TFM") ACCOUNT
 
    In addition to the considerable diversification among individual securities
you receive by investing in a particular Portfolio, you can further reduce risk
by spreading your assets among several different Portfolios that each have
different risk and return characteristics. TFM is an active investment
management service managed by Morgan Stanley or its affiliates, including Morgan
Stanley Asset Management Inc. (each, a "TFM Adviser"), that allocates your
investments across a combination of either Class A or Class B shares of certain
of the Portfolios selected to meet your long-term investment objectives as well
as, in certain circumstances, your current income objectives.
 
    The TFM Adviser has developed investment strategies for TFM Accounts to meet
the diverse financial needs of different investors. You can open a TFM Account
by meeting with one of the investment professionals of a Participating Dealer
who will review your situation and help you identify your long-term investment
and/or current income objectives. After using TFM criteria to determine your
long-term investment and/or current income objectives, you can choose one of
several TFM investment strategies. Based on your chosen strategy, your initial
investment will be allocated among a number of the Class A or Class B shares of
the Portfolios. Depending on market conditions, the TFM Adviser periodically
reallocates the combination of Portfolios or the percentage amounts invested in
the shares of each Portfolio to implement your TFM investment strategy. In
addition, your TFM Account will be periodically rebalanced to maintain your TFM
strategy's current asset allocation mix, if and when the performance of one or
more of the Portfolios unbalances the strategy's mix. You will pay the TFM
Adviser a fee for the TFM Account service that is in addition to and separate
from the fees and expenses you will pay directly or indirectly as an investor in
the Portfolios. See "Fund Expenses."
 
    From time to time, one or more of the Portfolios used for investment by the
TFM Accounts may experience relatively large investments or redemptions due to
the TFM Account allocations or rebalancings recommended by the TFM Adviser.
These transactions will affect the Portfolios, since Portfolios that experience
redemptions as a result of reallocations or rebalancings may have to sell
portfolio securities and Portfolios that receive additional cash will have to
invest it in additional portfolio securities. While it is impossible to predict
the overall impact of these transactions over time, there could be adverse
effects on portfolio management to the extent that Portfolios may be required to
sell securities or invest cash at times when they would not otherwise do so.
These transactions could also have tax consequences if sales of securities
resulted in gains and could also increase transaction costs. The Adviser,
representing the interests of the Portfolios, is committed to minimizing the
impact of TFM Account transactions on the Portfolios. The Adviser, however, will
have a conflict in fulfilling this responsibility in that it also serves as a
TFM Adviser. In that capacity, the Adviser, representing the interests of the
TFM Accounts, also is committed to minimizing the impact of TFM Account
transactions on the Portfolios to the extent consistent with pursuing the
investment objectives of the TFM Accounts. In addition, an affiliate of the TFM
Adviser, the Distributor is compensated on the sale, and may be compensated for
distribution or shareholder services on the sale of shares of the Portfolios.
See "Purchase of Shares" and "Shareholder Services -- Exchange Features." The
Adviser will monitor the impact of TFM Account transactions on the Portfolios.
 
                                       27
<PAGE>
                              REDEMPTION OF SHARES
 
    You may withdraw all or any portion of the amount in your account by
redeeming shares at any time. Please note that redemption proceeds for purchases
made by check may not be received until the payment of the purchase price has
been collected, which may take up to eight business days after purchase. The
Fund will redeem Class A shares of each Portfolio or Class B shares of each
Multiclass Portfolio at the next determined net asset value of shares of the
applicable class. On days that both the NYSE and the Custodian Bank are open for
business, the net asset value per share of each of the Portfolios is determined
at the regular close of trading of the NYSE (currently 4:00 p.m. Eastern Time).
Shares of each Portfolio may be redeemed by mail or telephone. No charge is made
for redemptions, except for the imposition of the 1% transaction fee described
under "Purchase of Shares" above, which may be assessed in connection with
redemptions of shares of the International Small Cap Portfolio. Any redemption
proceeds may be more or less than the purchase price of your shares depending
on, among other factors, the market value of the investment securities held by a
Portfolio.
 
BY MAIL
 
    Each Portfolio will redeem its Class A or Class B shares at the net asset
value determined on the date the request is received, if the request is received
in "good order" before the regular close of the NYSE. Your request should be
addressed to Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston,
Massachusetts 02208-2798, except that deliveries by overnight courier should be
addressed to Morgan Stanley Institutional Fund, Inc., c/o Chase Global Funds
Services Company, 73 Tremont Street, Boston, Massachusetts 02108-3913.
 
    "Good order" means that the request to redeem shares must include the
following documentation:
 
        (a)  A letter of instruction or a stock assignment specifying the class
    and number of shares or dollar amount to be redeemed, signed by all
    registered owners of the shares in the exact names in which they are
    registered;
 
        (b) Any required signature guarantees (see "Further Redemption
    Information" below); and
 
        (c)  Other supporting legal documents, if required, in the case of
    estates, trusts, guardianships, custodianships, corporations, pension and
    profit sharing plans and other organizations.
 
    Shareholders who are uncertain of requirements for redemption should consult
with a Fund representative.
 
BY TELEPHONE
 
    Provided you have previously elected the Telephone Redemption Option on the
Account Registration Form, you can request a redemption of your shares by
calling the Fund and requesting the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. In times of drastic market conditions, the telephone redemption option
may be difficult to implement. If you experience difficulty in making a
telephone redemption, your request may be made by regular mail or express mail
and it will be implemented at the net asset value next determined after it is
received. Redemption requests sent to the Fund through express mail must be
mailed to the address of the Dividend Disbursing and Transfer Agent listed under
"General Information." The Fund and the Fund's transfer agent (the "Transfer
Agent") will employ reasonable procedures to confirm that the instructions
communicated by telephone are genuine. These procedures include requiring the
investor to provide certain personal identification information at the time an
account is opened and prior to effecting each transaction requested by
telephone. In addition, all telephone
 
                                       28
<PAGE>
transaction requests will be recorded and investors may be required to provide
additional telecopied written instructions regarding transaction requests.
Neither the Fund nor the Transfer Agent will be responsible for any loss,
liability, cost or expense for following instructions received by telephone that
either of them reasonably believes to be genuine.
 
    To change the commercial bank or account designated to receive redemption
proceeds, a written request must be sent to the Fund at the address above.
Requests to change the bank or account must be signed by each shareholder and
each signature must be guaranteed.
 
FURTHER REDEMPTION INFORMATION
 
    Normally the Fund will make payment for all shares redeemed within one
business day of receipt of the request, but in no event will payment be made
more than seven days after receipt of a redemption request in good order.
However, payments to investors redeeming shares which were purchased by check
will not be made until payment for the purchase has been collected, which may
take up to eight days after the date of purchase. The Fund may suspend the right
of redemption or postpone the date upon which redemptions are effected at times
when the NYSE is closed, or under any emergency circumstances as determined by
the Securities and Exchange Commission (the "Commission").
 
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of a Portfolio to make payment
wholly or partly in cash, the Fund may pay the redemption proceeds in whole or
in part by a distribution in-kind of securities held by a Portfolio in lieu of
cash in conformity with applicable rules of the Commission.
Distributions-in-kind will be made in readily marketable securities. Investors
may incur brokerage charges on the sale of portfolio securities so received in
payment of redemptions.
 
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required for certain redemptions to verify the identity of the
person who has authorized a redemption from your account. Please contact the
Fund for further information.
 
                              SHAREHOLDER SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares that you own in any Portfolio for shares of any
other available portfolio(s) of the Fund (other than the International Equity
Portfolio, which is closed to new investors). In exchanging for shares of a
portfolio with more than one class, the class of shares you receive in the
exchange will be determined in the same manner as any other purchase of shares
and will not be based on the class of shares surrendered for the exchange.
Consequently, the same minimum initial investment and minimum account size for
determining the class of shares received in the exchange will apply. See
"Purchase of Shares." Shares of the portfolios may be exchanged by mail or
telephone. The privilege to exchange shares by telephone is automatic and made
available without shareholder election. Before you make an exchange, you should
read the prospectus of the portfolio(s) in which you seek to invest. Because an
exchange transaction is treated as a redemption followed by a purchase, an
exchange would be considered a taxable event for shareholders subject to tax.
The exchange privilege may be modified or terminated by the Fund at any time
upon 60-days notice to shareholders.
 
                                       29
<PAGE>
BY MAIL
 
    In order to exchange shares by mail, you should include in the exchange
request the name, class of shares and account number of your current Portfolio,
the name(s) of the portfolio(s) and class(es) of shares into which you intend to
exchange shares, and the signatures of all registered account holders. Send the
exchange request to Morgan Stanley Institutional Fund, Inc., P.O. Box 2798,
Boston, Massachusetts 02208-2798.
 
BY TELEPHONE
 
    When exchanging shares by telephone, have ready the name, class of shares
and account number of your current Portfolio, the name(s) of the portfolio(s)
and class(es) of shares into which you intend to exchange shares, your Social
Security number or Tax I.D. number, and your account address. Requests for
telephone exchanges received prior to 4:00 p.m. (Eastern Time) are processed at
the close of business that same day based on the net asset value of the
class(es) of the portfolios involved in the exchange of shares at the close of
business. Requests received after 4:00 p.m. (Eastern Time) are processed the
next business day based on the net asset value determined at the close of
business on such day. For additional information regarding responsibility for
the authenticity of telephoned instructions, see "Redemption of Shares -- By
Telephone" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by writing to Morgan Stanley Institutional Fund, Inc., P.O. Box 2798,
Boston, Massachusetts 02208-2798. As in the case of redemptions, the written
request must be received in good order before any transfer can be made.
Transferring the registration of shares may affect the eligibility of your
account for a given class of the Portfolio's shares may result in involuntary
conversion or redemption of your shares. See "Purchase of Shares" above.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of each of the Portfolios
is determined by dividing the total market value of the Portfolio's investments
and other assets attributable to such class, less any liabilities attributable
to such class, by the total number of outstanding shares of each class of the
Portfolio. Net asset value is calculated separately for each class of the
Portfolios. Net asset value per share is determined as of the regular close of
the NYSE on each day that the NYSE is open for business. Price information on
listed securities is taken from the exchange where the security is primarily
traded. Securities listed on a U.S. securities exchange for which market
quotations are available are valued at the last quoted sale price on the day the
valuation is made. Securities listed on a foreign exchange are valued at their
closing price. Unlisted securities and listed securities not traded on the
valuation date for which market quotations are readily available are valued at a
price within a range not exceeding the current asked price nor less than the
current bid price. The current bid and asked prices are determined based on the
average of the bid and asked prices quoted on such valuation date by reputable
brokers.
 
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily. In addition, bonds and other fixed income securities may be
valued on the basis of prices provided by a pricing service when such prices are
believed to reflect the fair market value of such securities. The prices
provided by a pricing service are determined without regard to bid or last sale
prices but take into account institutional size, trading in similar groups of
securities and any developments related to the
 
                                       30
<PAGE>
specific securities. Securities not priced in this manner are valued at the most
recently quoted bid price or, when securities exchange valuations are used, at
the latest quoted sale price on the day of valuation. If there is no such
reported sale, the latest quoted bid price will be used. Securities purchased
with remaining maturities of 60 days or less are valued at amortized cost, if it
approximates market value. In the event that amortized cost does not approximate
market value, market prices as determined above will be used.
 
    The value of other assets and securities for which quotations are not
readily available (including restricted and unlisted foreign securities) and
those securities for which it is inappropriate to determine the prices in
accordance with the above-stated procedures are determined in good faith at fair
value using methods determined by the Board of Directors. For purposes of
calculating net asset value per share, all assets and liabilities initially
expressed in foreign currencies will be translated into U.S. dollars at the mean
of the bid and asked price for such currencies against the U.S. dollar last
quoted by any major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distribution expense accrual differential among the classes. The
net asset value of Class B shares will generally be lower than the net asset
value of the Class A shares as a result of the distribution expenses charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise the "total return" for each class
of a Portfolio. THESE FIGURES ARE BASED ON HISTORICAL EARNINGS AND ARE NOT
INTENDED TO INDICATE FUTURE PERFORMANCE.
 
    Each of the Portfolios may advertise "total return" which shows what an
investment in a class of a Portfolio would have earned over a specified period
of time (such as one, five or ten years) assuming that all distributions and
dividends by the Portfolio were reinvested in the same class on the reinvestment
dates during the period. Total return does not take into account any federal or
state income taxes that may be payable on dividends and distributions or on
redemption. The Fund may also include comparative performance information in
advertising or marketing the Portfolios' shares, including data from Lipper
Analytical Services, Inc., other industry publications, business periodicals,
rating services and market indices.
 
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains distributions for a class of shares
will be automatically reinvested in additional shares at net asset value, except
that, upon written notice to the Fund or by checking off the appropriate box in
the Distribution Option Section on the Account Registration Form, a shareholder
may elect to receive income dividends and capital gains distributions in cash.
 
    Each Portfolio expects to distribute substantially all of its taxable net
investment income in the form of annual dividends. Net realized capital gains,
if any, after reduction for any available tax loss carryforwards will also be
distributed annually.
 
                                       31
<PAGE>
    Undistributed net investment income is included in a Portfolio's net assets
for the purpose of calculating net asset value per share. Therefore, on the
"ex-dividend" date, the net asset value per share excludes the dividend (i.e.,
is reduced by the per share amount of the dividend). Dividends paid shortly
after the purchase of shares by an investor, although in effect a return of
capital, are taxable to shareholders subject to income tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of the Portfolios will differ at times.
Expenses of the Portfolios allocated to a particular class of shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of the Portfolios or their shareholders.
Accordingly, shareholders are urged to consult their tax advisers regarding
specific questions as to federal, state and local income taxes.
 
    Each Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other portfolios. Each Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Code, so that the Portfolio will be relieved
of federal income tax on that part of its net investment income and net capital
gain that is distributed to shareholders.
 
    Each Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, net short-term capital gain) to
shareholders. Dividends from a Portfolio's net investment income are taxable to
shareholders as ordinary income, whether received in cash or in additional
shares. Such dividends paid by a Portfolio will generally qualify for the 70%
dividends-received deduction for corporate shareholders only to the extent of
the aggregate qualifying dividend income received by the Portfolio from U.S.
corporations. Each Portfolio will report annually to its shareholders the amount
of dividend income qualifying for such treatment.
 
    Distributions of net capital gain (the excess of net long-term capital gain
over net short-term capital loss) are taxable to shareholders as long-term
capital gain, regardless of how long shareholders have held their shares. Each
Portfolio will send reports annually to its shareholders of the federal income
tax status of all distributions made during the preceding year.
 
    Each Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gain over short-term and long-term capital
loss, including any available capital loss carryforwards) prior to the end of
each calendar year to avoid liability for federal excise tax.
 
    Dividends and other distributions declared by a Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders in that year if the distributions are paid by the Portfolio at
any time during the following January.
 
                                       32
<PAGE>
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any dividends, capital gains distributions and redemption proceeds paid to any
individual or certain other non-corporate shareholder (1) who has failed to
provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Application Form, (2) who is subject to backup withholding by the Internal
Revenue Service, or (3) who has not certified to the Fund that such shareholder
is not subject to backup withholding. This backup withholding is not an
additional tax, and any amounts withheld may be credited against the
shareholder's ultimate U.S. tax liability.
 
    The sale, exchange or redemption of shares will result in taxable gain or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the sale, exchange or redemption proceeds exceed or are
less than the shareholder's adjusted basis in the sold, exchanged or redeemed
shares. If capital gain distributions have been made with respect to shares that
are sold at a loss after being held for six months or less, then the loss is
treated as a long-term capital loss to the extent of the capital gain
distributions.
 
    Conversion of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisors concerning the
application of state and local income taxes to investments in a Portfolio, which
may differ from the federal income tax consequences described above.
 
    Investment income received by a Portfolio from sources within foreign
countries may be subject to foreign income taxes withheld at the source. To the
extent that a Portfolio is liable for foreign income taxes so withheld, each
Portfolio intends to operate so as to meet the requirements of the Code to pass
through to the shareholders credit for foreign income taxes paid. Although each
Portfolio intends to meet Code requirements to pass through credit for such
taxes, there can be no assurance that each Portfolio will be able to do so.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN A PORTFOLIO.
 
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolio
for their clients.
 
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other
 
                                       33
<PAGE>
remuneration paid to Morgan Stanley or other affiliates must be fair and
reasonable in comparison to those of other broker-dealers for comparable
transactions involving similar securities being purchased or sold during a
comparable time period.
 
PORTFOLIO TURNOVER
 
    The Portfolios generally do not invest for short-term trading purposes,
however, when circumstances warrant, each Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolios will not consider portfolio turnover rate
a limiting factor in making investment decisions consistent with their
respective objectives and policies. As portfolio turnover increases, the
Portfolios may expect to pay correspondingly increased brokerage and trading
costs. In addition to transaction costs, higher portfolio turnover may result in
the realization of capital gains. As discussed under "Taxes," to the extent net
short-term capital gains are realized, any distributions resulting from such
gains are considered ordinary income for federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 38 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of each
Portfolio are currently classified into two classes, the Class A shares and the
Class B shares, except for the International Small Cap, Money Market and
Municipal Money Market Portfolios, which offer only Class A shares.
 
    The shares of each Portfolio, when issued, will be fully paid,
nonassessable, fully transferable and redeemable at the option of the holder.
The shares have no preference as to conversion, exchange, dividends, retirement
or other features and have no pre-emptive rights. The shares of each Portfolio
have non-cumulative voting rights, which means that the holders of more than 50%
of the shares voting for the election of Directors can elect 100% of the
Directors if they choose to do so. Persons or organizations owning 25% or more
of the outstanding shares of a Portfolio may be presumed to "control" (as
defined in the 1940 Act) such Portfolio. Under Maryland law, the Fund is not
required to hold an annual meeting of its shareholders unless required to do so
under the 1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual, semi-annual and quarterly
reports; the financial statements appearing in annual reports are audited by
independent accountants. Monthly unaudited portfolio data is also available from
the Fund upon request.
 
    In addition, the Adviser or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
                                       34
<PAGE>
CUSTODIAN
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs sub-custodians approved by the Board of Directors of the Fund
in accordance with regulations of the Securities and Exchange Commission for the
purpose of providing custodial services for such assets. MSTC may also hold
certain domestic assets for the Fund. For more information on the custodians,
see "General Information -- Custody Arrangements" in the Statement of Additional
Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits its annual financial statements.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       35
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
  ASIAN EQUITY AND JAPANESE EQUITY PORTFOLIOS
   P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                            <C>
      ACCOUNT INFORMATION                            If you need assistance in filling out this form for the Morgan Stanley
      Fill in where applicable                       Institutional Fund, please contact your Morgan Stanley representative
                                                     or call us toll free 1-800-548-7786. Please print all items except
                                                     signature, and mail to the Fund at the address above.
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
         TENANCY IN COMMON
         IS INDICATED)
</TABLE>
 
1.
         First Name    Initial         Last Name
2.
         First Name    Initial         Last Name
         First Name    Initial         Last Name
 
<TABLE>
<C>   <S>                                            <C>
      3. CORPORATIONS,
         TRUSTS AND OTHERS
         Please call the Fund for additional
      documents that may be required to set up
      account and to authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                     <C>                 <C>                   <C>               <C>
Type of Registration:   / / INCORPORATED    / / UNINCORPORATED    / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                            ASSOCIATION                               (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
 
<TABLE>
<C>   <S>                                            <C>
  B)  MAILING ADDRESS
      Please fill in completely, including
      telephone number(s).
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
/ / Non-Resident Alien:
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
 
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
 
<TABLE>
<C>   <S>                                            <C>                                  <C>
  C)  TAXPAYER                                       Enter your Taxpayer Identification Number. For most individual
      IDENTIFICATION                                 taxpayers, this is your Social Security Number.
      NUMBER
      1. INDIVIDUAL
      2.   JOINT TENANTS
           (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
           TENANCY IN COMMON
           IS INDICATED)
      For Custodian account
      of a minor (Uniform
      Gifts/Transfers to Minor
      Acts), give the Social
      Security Number of
      the minor
                                                                                          OR
                                                     1.         TAXPAYER IDENTIFICATION                      SOCIAL SECURITY
                                                     NUMBER ("TIN")                                NUMBER ("SSN")
                                                                                              OR
                                                     2.                             TIN
                                                                                                                             SSN
                                                                                              OR
                                                     TIN
                                                                                                                             SSN
                                                     IMPORTANT TAX INFORMATION
                                                     You (as a payee) are required by law to provide us (as payer) with your
                                                     correct TIN(s) or SSN(s). Accounts that have a missing or incorrect
                                                     TIN(s) or SSN(s) will be subject to backup withholding at a 31% rate on
                                                     dividends, distributions and other payments. If you have not provided us
                                                     with your correct TIN(s) or SSN(s), you may be subject to a $50 penalty
                                                     imposed by the Internal Revenue Service.
                                                     Backup withholding is not an additional tax; the tax liability of
                                                     persons subject to backup withholding will be reduced by the amount of
                                                     tax withheld. If withholding results in an overpayment of taxes, a
                                                     refund may be obtained.
                                                     You may be notified that you are subject to backup withholding under
                                                     Section 3406(a)(1)(C) of the Internal Revenue Code because you have
                                                     underreported interest or dividends or you were required to, but failed
                                                     to, file a return which would have included a reportable interest or
                                                     dividend payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>                             <C>                   <C>
  D)  PORTFOLIO AND                        For Purchase of the following   / / Class A Shares $  / / Class B Shares $
      CLASS SECTION                        Portfolio(s):                   / / Class A Shares $  / / Class B Shares $
      (Class A shares minimum $500,000     Asian Equity Portfolio
      for each Portfolio and Class B       Japanese Equity Portfolio
      shares minimum $100,000 for each
      Portfolio). Please indicate
      Portfolio, class and amount.
                                                                           Total Initial Investment $
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate
      portfolio, manner of
      payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                          <C>
/ / Exchange $ From                                                                     -- - - - - - - - - - -- - -
                            Name of Portfolio                                                   Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on                 -- - - - - - - - - - -- - -
                                                                                      Account No.               (Check
                                                                                (Previously assigned by the Fund)     Digit)
                                                                                                                          Date
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  F)  DISTRIBUTION               Income dividends and capital gains distributions (if any) to
      OPTION                     be reinvested in additional shares unless either box below
                                 is checked.
                                 / / Income dividends to be paid in cash, capital gains
                                 distributions (if any) in shares.
                                 / / Income dividends and capital gains distributions (if
                                 any) to be paid in cash.
</TABLE>
 
<TABLE>
<C>   <S>                             <C>                                       <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone         Name of COMMERCIAL Bank (Not Savings
      AND EXCHANGE                    requests to wire redemption proceeds to   Bank)
      OPTION                          the commercial bank indicated at right    Bank Account No.
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund
      wish to redeem or exchange      account is registered if such requests                                        Bank
      shares by telephone. A          are believed to be authentic.                                                  ABA
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent                                         No.
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated    Name(s) in which your Bank Account is
      YOUR FUND ACCOUNT.              by telephone are genuine. These           Established
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal      Bank's Street
      NOT BE HONORED UNLESS THE BOX   identification information at the time    Address
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by   City  State  Zip
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  H)  INTERESTED PARTY
      OPTION                                                                                                Name
      In addition to the account
      statement sent to my/our registered
      address, I/we hereby authorize the                                                                   Address
      Fund to mail duplicate statements
      to the name and address provided at  City         State         Zip Code
      right.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  I)  DEALER
      INFORMATION
                                           Representative Name              Representative No.             Branch
                                           No.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here ,
</TABLE>
 
<TABLE>
<S>                                  <C>
The undersigned certify that I/we have full authority and legal capacity
to purchase and redeem shares of the Fund and affirm that I/we have
received a current Prospectus of the Morgan Stanley Institutional Fund,
Inc. and agree to be bound by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF
PERJURY THAT THE INFORMATION ON THIS APPLICATION IS COMPLETE AND CORRECT
AND THAT AS REQUIRED BY FEDERAL LAW (PLEASE CHECK APPLICABLE BOXES
BELOW):
 
/ / U.S. CITIZEN(S)/TAXPAYER(S):
 
      / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM
          IS/ARE THE CORRECT SSN(S) OR TIN(S) AND (2) I/WE ARE NOT
          SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE ARE
          EXEMPT FROM BACKUP WITHHOLDING; (B) I/WE HAVE NOT BEEN
          NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT I/WE ARE
          SUBJECT TO BACKUP WITHHOLDING AS A RESULT OF A FAILURE TO
          REPORT ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED
          ME/US THAT I AM/WE ARE NO LONGER SUBJECT TO BACKUP
          WITHHOLDING.
 
      / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE HAVE
          APPLIED, OR INTEND TO APPLY, TO THE IRS OR THE SOCIAL SECURITY
          ADMINISTRATION FOR A TIN OR A SSN AND I/WE UNDERSTAND THAT IF
          I/ WE DO NOT PROVIDE EITHER NUMBER TO CHASE GLOBAL FUNDS
          SERVICES COMPANY ("CGFSC") WITHIN 60 DAYS OF THE DATE OF THIS
          APPLICATION OR IF I/WE FAIL TO FURNISH MY/OUR CORRECT SSN(S)
          OR TIN(S), I/WE MAY BE SUBJECT TO A PENALTY AND A 31% BACKUP
          WITHHOLDING ON DISTRIBUTIONS AND REDEMPTION PROCEEDS. (PLEASE
          PROVIDE EITHER NUMBER ON IRS FORM W-9). YOU MAY REQUEST SUCH
          FORM BY CALLING CGFSC AT 800-282-4404.
 
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
  UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S.
CITIZENS OR RESIDENTS AND I/WE ARE EXEMPT FOREIGN PERSONS AS DEFINED BY
THE INTERNAL REVENUE SERVICE.
 
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY
PROVISION OF THIS DOCUMENT OTHER THAN THE CERTIFICATIONS REQUIRED TO
AVOID BACKUP WITHHOLDING.
 
                                     (X)
(X)                                  Signature (if joint account, both
Signature            Date            must sign)      Date
</TABLE>
<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<CAPTION>
                                                    PAGE
                                                    ----
<S>                                                 <C>
Fund Expenses.....................................    2
Financial Highlights..............................    4
Prospectus Summary................................    7
Investment Objectives and Policies................   11
Additional Investment Information.................   13
Investment Limitations............................   20
Management of the Fund............................   20
Purchase of Shares................................   22
Redemption of Shares..............................   28
Shareholder Services..............................   29
Valuation of Shares...............................   30
Performance Information...........................   31
Dividends and Capital Gains Distributions.........   31
Taxes.............................................   32
Portfolio Transactions............................   33
General Information...............................   34
Account Registration Form
</TABLE>
 
                             ASIAN EQUITY PORTFOLIO
                           JAPANESE EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
 
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  Incorporated
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                      P.O. BOX 2798, BOSTON, MA 02208-2798
 
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
- --------------------------------------------------------------------------------
 
                           EMERGING MARKETS PORTFOLIO
                        EMERGING MARKETS DEBT PORTFOLIO
                            LATIN AMERICAN PORTFOLIO
 
                               PORTFOLIOS OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
                                ----------------
 
    Morgan  Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a   series   of   diversified   and   non-diversified   investment    portfolios
("portfolios").  The  Fund  is  designed  to  provide  clients  with  attractive
alternatives for meeting their investment needs. The Fund currently consists  of
thirty-two  portfolios representing  a broad  range of  investment choices. This
prospectus (the "Prospectus") pertains to the Class A and the Class B shares  of
the Emerging Markets, Emerging Markets Debt and Latin American Portfolios (each,
a   "Portfolio"  and  collectively,  the  "Portfolios").  The  Emerging  Markets
Portfolio is currently  closed to new  investors with the  exception of  certain
Morgan  Stanley &  Co. Incorporated  ("Morgan Stanley")  customers, employees of
Morgan Stanley,  certain tax-qualified  retirement  plans and  other  investment
companies  advised by Morgan  Stanley Asset Management  Inc. and its affiliates.
The Class  A  and  Class B  shares  currently  offered by  the  Portfolios  have
different  minimum  investment requirements  and  fund expenses.  Shares  of the
portfolios are offered  with no sales  charge, exchange fee  or redemption  fee,
(except  that the  International Small  Cap Portfolio  may impose  a transaction
fee).
 
    THE EMERGING MARKETS PORTFOLIO  MAY INVEST IN  EQUITY SECURITIES OF  RUSSIAN
COMPANIES.  RUSSIA'S SYSTEM OF  SHARE REGISTRATION AND  CUSTODY INVOLVES CERTAIN
RISKS OF  LOSS  THAT ARE  NOT  NORMALLY  ASSOCIATED WITH  INVESTMENTS  IN  OTHER
SECURITIES MARKETS. SEE "ADDITIONAL INVESTMENT INFORMATION -- RUSSIAN SECURITIES
TRANSACTIONS."
 
    The  Fund is designed  to meet the investment  needs of discerning investors
who place a premium on quality  and personal service. With Morgan Stanley  Asset
Management   Inc.  as   Adviser  and   Administrator  (the   "Adviser"  and  the
"Administrator")  and  with  Morgan  Stanley  as  Distributor,  the  Fund  makes
available  to institutional and high net  worth individual investors a series of
portfolios which  benefit  from  the  investment  expertise  and  commitment  to
excellence associated with Morgan Stanley and its affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund  that a prospective investor should know  before investing and it should be
retained for future reference. The  Fund offers additional portfolios which  are
described  in other prospectuses  and under the  "Prospectus Summary" below. The
Fund currently offers  the following  portfolios: (i)  GLOBAL AND  INTERNATIONAL
EQUITY  -- Active Country Allocation, Asian  Equity, Asian Real Estate, Emerging
Markets,  European   Equity,  European   Real  Estate,   Global  Equity,   Gold,
International  Equity, International  Magnum, International  Small Cap, Japanese
Equity and Latin  American Portfolios;  (ii) U.S. EQUITY  -- Aggressive  Equity,
Emerging  Growth, Equity Growth, Small Cap Value Equity, Technology, U.S. Equity
Plus, U.S. Real Estate and Value  Equity Portfolios; (iii) BALANCED --  Balanced
Portfolio;  (iv) FIXED  INCOME --  Emerging Markets  Debt, Fixed  Income, Global
Fixed Income, High Yield and Municipal Bond Portfolios; and (v) MONEY MARKET  --
Money Market and Municipal Money Market Portfolios. Additional information about
the  Fund is contained in a "Statement  of Additional Information," dated May 1,
1997, as supplemented through September  26, 1997, which is incorporated  herein
by  reference.  The Statement  of  Additional Information  and  the prospectuses
pertaining to the other  portfolios of the Fund  are available upon request  and
without  charge by  writing or  calling the  Fund at  the address  and telephone
number set forth above.
 
   THESE SECURITIES HAVE NOT BEEN  APPROVED OR DISAPPROVED BY THE  SECURITIES
       AND  EXCHANGE  COMMISSION,  NOR HAS  THE  SECURITIES  AND EXCHANGE
            COMMISSION PASSED UPON THE ACCURACY OR ADEQUACY OF  THIS
                PROSPECTUS.  ANY REPRESENTATION  TO THE CONTRARY
                IS A
                                       CRIMINAL OFFENSE.
 
                   THE DATE OF THIS PROSPECTUS IS MAY 1, 1997
                   AS SUPPLEMENTED THROUGH SEPTEMBER 26, 1997
<PAGE>
                                 FUND EXPENSES
 
    The  following table illustrates the expenses and fees that a shareholder of
the Portfolios indicated below will incur:
<TABLE>
<CAPTION>
                                                                                   EMERGING
                                                                      EMERGING      MARKETS       LATIN
                                                                       MARKETS       DEBT       AMERICAN
SHAREHOLDER TRANSACTION EXPENSES                                      PORTFOLIO    PORTFOLIO    PORTFOLIO
- -------------------------------------------------------------------  -----------  -----------  -----------
<S>                                                                  <C>          <C>          <C>
Maximum Sales Load Imposed on Purchases
  Class A..........................................................        None         None         None
  Class B..........................................................        None         None         None
Maximum Sales Load Imposed on Reinvested Dividends
  Class A..........................................................        None         None         None
  Class B..........................................................        None         None         None
Deferred Sales Load
  Class A..........................................................        None         None         None
  Class B..........................................................        None         None         None
Redemption Fees
  Class A..........................................................        None         None         None
  Class B..........................................................        None         None         None
Exchange Fees
  Class A..........................................................        None         None         None
  Class B..........................................................        None         None         None
 
<CAPTION>
 
ANNUAL FUND OPERATING EXPENSES
- -------------------------------------------------------------------
 (AS A PERCENTAGE OF AVERAGE NET ASSETS)
<S>                                                                  <C>          <C>          <C>
Management Fee (Net of Fee Waivers)*
  Class A..........................................................       1.25%        1.00%        0.62%
  Class B..........................................................       1.25%        1.00%        0.62%
12b-1 Fees
  Class A..........................................................        None         None         None
  Class B..........................................................       0.25%        0.25%        0.25%
Other Expenses
  Class A..........................................................       0.49%        0.40%        1.08%
  Class B..........................................................       0.49%        0.40%        1.08%
                                                                     -----------  -----------  -----------
Total Operating Expenses (Net of Fee Waivers)*
  Class A..........................................................       1.74%        1.40%        1.70%
  Class B..........................................................       1.99%        1.65%        1.95%
                                                                     -----------  -----------  -----------
                                                                     -----------  -----------  -----------
</TABLE>
 
- ------------------------------
*The Adviser  has agreed  to  waive its  management  fees and/or  reimburse  the
 Portfolios,  if  necessary, if  such fees  would  cause total  annual operating
 expenses, as a percentage of average daily net assets, to exceed 1.75% for  the
 Class  A shares and  2.00% for the Class  B shares of  the Emerging Markets and
 Emerging Markets Debt Portfolios or to exceed 1.70% for the Class A shares  and
 1.95%  for the Class B  shares of the Latin  American Portfolio. The management
 fees are 1.25% for  the Emerging Markets Portfolio  and 1.00% for the  Emerging
 Markets Debt Portfolio. Absent the fee waiver and/or expense reimbursement, the
 Latin  American Portfolio's management  fee would be  1.10% and total operating
 expenses would be 2.18% of the average  daily net assets of the Class A  shares
 and 2.43% of the average daily net assets of the Class B shares. As a result of
 these  reductions, the Management  Fee for the  Latin American Portfolio stated
 above is lower than the contractual fee stated under "Management of the  Fund."
 The  Adviser reserves  the right  to terminate  any of  its fee  waivers and/or
 expense reimbursements at any time in its sole discretion. The Adviser reserves
 the right to terminate any of its fee waivers and/or expense reimbursements  at
 any  time in its sole discretion. For further information on Fund expenses, see
 "Management of the Fund."
 
                                       2
<PAGE>
    The purpose of the  table above is to  assist the investor in  understanding
the  various expenses that an  investor in the Portfolios  will bear directly or
indirectly. Expenses and fees for the Portfolios are based on actual figures for
the fiscal year ended December  31, 1996. Due to  the continuous nature of  Rule
12b-1  fees, long-term Class B shareholders may  pay more than the equivalent of
the  maximum  front-end  sales  charges  otherwise  permitted  by  the  National
Association of Securities Dealers, Inc. ("NASD") Conduct Rules.
 
    The  following  example illustrates  the expenses  that you  would pay  on a
$1,000 investment assuming (1) a 5% annual rate of return and (2) redemption  at
the  end of each time period. As noted in the table above, the Portfolios charge
no redemption  fees  of  any kind.  The  following  example is  based  on  total
operating expenses of the Portfolios after fee waivers.
 
<TABLE>
<CAPTION>
                                                                       1 YEAR       3 YEARS      5 YEARS     10 YEARS
                                                                     -----------  -----------  -----------  -----------
<S>                                                                  <C>          <C>          <C>          <C>
Emerging Markets Portfolio
  Class A..........................................................   $      18    $      55    $      94    $     205
  Class B..........................................................          20           62          107          232
Emerging Markets Debt Portfolio
  Class A..........................................................          27           84          143          303
  Class B..........................................................          28           87          148          314
Latin American Portfolio
  Class A..........................................................          17           54           92          201
  Class B..........................................................          20           61          105          227
</TABLE>
 
    THIS  EXAMPLE SHOULD  NOT BE CONSIDERED  A REPRESENTATION OF  PAST OR FUTURE
EXPENSES OR  PERFORMANCE. ACTUAL  EXPENSES MAY  BE GREATER  OR LESS  THAN  THOSE
SHOWN.
 
                                       3
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The  following tables provide financial highlights for the Class A and Class
B shares for  the Emerging  Markets, Emerging  Markets Debt  and Latin  American
Portfolios  for each of the periods  presented. The audited financial highlights
for the Portfolios' shares  for each of  the periods presented  are part of  the
Fund's  financial statements which appear in the Fund's December 31, 1996 Annual
Report to Shareholders and which are  incorporated by reference into the  Fund's
Statement  of Additional  Information. The Portfolios'  financial highlights for
each of the periods presented have  been audited by Price Waterhouse LLP,  whose
unqualified  report thereon is also incorporated by reference into the Statement
of Additional Information. Additional performance information is included in the
Annual Report. The  Annual Report  and the financial  statements therein,  along
with  the Statement of Additional Information, are available at no cost from the
Fund at  the address  and  telephone number  noted on  the  cover page  of  this
Prospectus.  After October  31, 1992,  the Fund changed  its fiscal  year end to
December 31. The following  information should be read  in conjunction with  the
financial statements and notes thereto.
 
                                       4
<PAGE>
                           EMERGING MARKETS PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                     CLASS A                                              CLASS B
                             ----------------------------------------------------------------------------------------   ------------
                                                                                                         PERIOD FROM    PERIOD FROM
                                                                                          TWO MONTHS    SEPTEMBER 25,    JANUARY 2,
                              YEAR ENDED     YEAR ENDED     YEAR ENDED     YEAR ENDED       ENDED         1992* TO       1996*** TO
                             DECEMBER 31,   DECEMBER 31,   DECEMBER 31,   DECEMBER 31,   DECEMBER 31,    OCTOBER 31,    DECEMBER 31,
                                 1996           1995           1994           1993           1992           1992            1996
                             ------------   ------------   ------------   ------------   ------------   -------------   ------------
<S>                          <C>            <C>            <C>            <C>            <C>            <C>             <C>
NET ASSET VALUE, BEGINNING
 OF PERIOD.................   $    13.14      $  16.30       $  19.00       $  10.22       $ 10.11         $ 10.00        $ 13.25
                             ------------   ------------   ------------   ------------   ------------   -------------   ------------
                             ------------   ------------   ------------   ------------   ------------   -------------   ------------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Income
   (Loss) (1)..............         0.09          0.08          (0.04)         (0.01)           --              --           0.04
  Net Realized and
   Unrealized Gain (Loss)
   on Investments..........         1.51         (2.05)         (1.69)          8.79          0.11            0.11           1.42
                             ------------   ------------   ------------   ------------   ------------   -------------   ------------
    Total from Investment
     Operations............         1.60         (1.97)         (1.73)          8.78          0.11            0.11           1.46
                             ------------   ------------   ------------   ------------   ------------   -------------   ------------
DISTRIBUTIONS
  Net Investment Income....        (0.08)        (0.06)            --             --            --              --          (0.05)
  Net Realized Gain........           --         (1.13)         (0.97)            --            --              --             --
                             ------------   ------------   ------------   ------------   ------------   -------------   ------------
    Total Distributions....        (0.08)        (1.19)         (0.97)            --            --              --          (0.05)
                             ------------   ------------   ------------   ------------   ------------   -------------   ------------
NET ASSET VALUE, END OF
 PERIOD....................   $    14.66      $  13.14       $  16.30       $  19.00       $ 10.22         $ 10.11        $ 14.66
                             ------------   ------------   ------------   ------------   ------------   -------------   ------------
TOTAL RETURN...............        12.19%       (12.77)%        (9.63)%        85.91%         1.09%           1.10%         11.04%
                             ------------   ------------   ------------   ------------   ------------   -------------   ------------
                             ------------   ------------   ------------   ------------   ------------   -------------   ------------
RATIOS AND SUPPLEMENTAL
 DATA:
  Net Assets, End of Period
   (Thousands).............   $1,304,006      $876,591       $929,638       $735,352       $74,219         $28,806        $14,213
  Ratio of Expenses to
   Average Net Assets
   (1).....................         1.74%         1.72%          1.75%          1.75%         1.75%**         1.75%**        1.99%**
  Ratio of Net Investment
   Income (Loss) to Average
   Net Assets (1)..........         0.69%         0.60%         (0.26)%        (0.06)%       (0.33)%**       (0.53)%**       0.33%**
  Portfolio Turnover
   Rate....................           55%           54%            32%            52%            2%              0%            55%
  Average Commission
   Rate#...................      $0.0006           N/A            N/A            N/A           N/A             N/A        $0.0006
</TABLE>
 
- --------------------
 
<TABLE>
<C> <S>                        <C>           <C>            <C>            <C>           <C>             <C>             <C>
(1) Effect of voluntary
     expense limitation
     during the period:
      Per share benefit to
       net investment
       income..............          N/A           N/A            N/A          $0.01         $0.00           $0.02             N/A
    Ratios before expense
     limitation:
      Expenses to Average
       Net Assets..........          N/A           N/A            N/A           1.79%         2.48%**         4.82%**          N/A
      Net Investment Loss
       to Average Net
       Assets..............          N/A           N/A            N/A          (0.10)%       (1.06)%**       (3.60)%**         N/A
</TABLE>
 
  * Commencement of Operations.
 
 ** Annualized
 
*** The Portfolio began offering Class B Shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period. For the year ended December 31,
   1996, the average commission rate paid on trades on which commissions were
   charged was 0.42% of the trade amount.
 
                                       5
<PAGE>
                        EMERGING MARKETS DEBT PORTFOLIO
 
<TABLE>
<CAPTION>
                                                           CLASS A                       CLASS B
                                          ------------------------------------------   ------------
                                                                        PERIOD FROM    PERIOD FROM
                                                                        FEBRUARY 1,     JANUARY 2,
                                           YEAR ENDED     YEAR ENDED      1994* TO      1996*** TO
                                          DECEMBER 31,   DECEMBER 31,   DECEMBER 31,   DECEMBER 31,
                                              1996           1995           1994           1996
                                          ------------   ------------   ------------   ------------
<S>                                       <C>            <C>            <C>            <C>
NET ASSET VALUE, BEGINNING OF PERIOD....    $   8.59       $   8.59       $  10.00        $ 8.68
                                          ------------   ------------   ------------      ------
                                          ------------   ------------   ------------      ------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income.................        1.54           1.36           0.50          1.01
  Net Realized and Unrealized Gain
   (Loss) on Investments................        2.79           0.91         (1.91)          3.20
                                          ------------   ------------   ------------      ------
    Total from Investment Operations....        4.33           2.27         (1.41)          4.21
                                          ------------   ------------   ------------      ------
DISTRIBUTIONS
  Net Investment Income.................       (1.17)         (1.86)            --        (1.15)
  In Excess of Net Investment Income....       (0.01)            --             --        (0.01)
  Net Realized Gain.....................       (4.20)         (0.41)            --        (4.20)
                                          ------------   ------------   ------------      ------
    Total Distributions.................       (5.38)         (2.27)            --        (5.36)
                                          ------------   ------------   ------------      ------
NET ASSET VALUE, END OF PERIOD..........    $   7.54       $   8.59       $   8.59        $ 7.53
                                          ------------   ------------   ------------      ------
                                          ------------   ------------   ------------      ------
TOTAL RETURN............................       50.52%         28.23%        (14.10)%       48.52%
                                          ------------   ------------   ------------      ------
                                          ------------   ------------   ------------      ------
RATIO AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)..........................    $152,142       $181,878       $144,949        $4,253
  Ratio of Expenses to Average Net
   Assets...............................        2.70%          1.75%          1.49%**       2.81%**
  Ratio of Expenses to Average Net
   Assets (Excluding Dividend and
   Interest Expense)....................        1.42%           N/A            N/A          1.65%**
  Ratio of Net Investment Income to
   Average Net Assets...................       11.66%         14.70%          9.97%**      11.09%**
  Portfolio Turnover Rate...............         560%           406%           273%          560%
</TABLE>
 
- --------------
  * Commencement of operations.
 
 ** Annualized
 
*** The Portfolio began offering Class B Shares on January 2, 1996.
 
                                       6
<PAGE>
                            LATIN AMERICAN PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                CLASS A
                                               -----------------------------------------
                                                                         PERIOD FROM             CLASS B
                                                                         JANUARY 18,       -------------------
                                                   YEAR ENDED         1995* TO DECEMBER    PERIOD FROM JANUARY
                                                  DECEMBER 31,               31,              2, 1996*** TO
                                                      1996                  1995            DECEMBER 31, 1996
                                               -------------------   -------------------   -------------------
<S>                                            <C>                   <C>                   <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........  $          9.06       $         10.00       $          9.44
                                                       -------               -------               -------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)..................             0.14                  0.05                  0.09
  Net Realized and Unrealized Gain (Loss) on
   Investments...............................             4.27                 (0.92)                 3.90
                                                       -------               -------               -------
    Total from Investment Operations.........             4.41                 (0.87)                 3.99
                                                       -------               -------               -------
DISTRIBUTIONS
  Net Investment Income......................            (0.13)                (0.04)                (0.10)
  Net Realized Gain..........................            (2.02)                   --                 (2.02)
  Return of Capital..........................               --                 (0.03)                   --
                                                       -------               -------               -------
    Total Distributions......................            (2.15)                (0.07)                (2.12)
                                                       -------               -------               -------
Net Asset Value, End of Period...............  $         11.32       $          9.06       $         11.31
                                                       -------               -------               -------
                                                       -------               -------               -------
Total Return.................................            48.77%                (8.68)%               42.44%
                                                       -------               -------               -------
                                                       -------               -------               -------
Ratios and Supplemental Data:
  Net Assets, End of Period (Thousands)......  $        30,409       $        15,376                $1,333
  Ratio of Expenses to Average Net Assets
   (1).......................................             1.70%                 1.70%**               1.95%**
  Ratio of Net Investment Income to Average
   Net Assets (1)............................             1.21%                 0.62%**               0.89%**
  Portfolio Turnover Rate....................              192%                  137%                  192%
  Average Commission Rate#...................          $0.0004                   N/A               $0.0004
</TABLE>
 
- --------------
 
<TABLE>
<C> <S>                                       <C>                   <C>                   <C>
(1) Effect of voluntary expense limitation
     during the period:
      Per share benefit to net investment
       income................................            $0.05                 $0.09                 $0.05
    Ratios before expense limitation:
      Expenses to Average Net Assets.........             2.18%                 3.13%**               2.43%**
      Net Investment Loss to Average Net
       Assets................................             0.75%                (0.48)%**              0.42%**
</TABLE>
 
  * Commencement of Operations.
 
 ** Annualized
 
*** The Portfolio began offering Class B Shares on January 2, 1996.
 
 # Beginning  with fiscal year  1996, the Portfolio is  required to disclose the
   average commission rate  per share  it paid  for portfolio  trades, on  which
   commissions  were charged, during the period. For the year ended December 31,
   1996, the average commission  rate paid on trades  on which commissions  were
   charged was 0.30% of the trade amount.
 
                                       7
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and  high net  worth individual  investors a  broad range  of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates  providing  customized   services  as   Adviser,  Administrator   and
Distributor.   Each  portfolio  offers  Class  A  shares  and,  except  for  the
International Small Cap,  Money Market  and Municipal  Money Market  Portfolios,
also  offers Class B shares. Each portfolio has its own investment objective and
policies designed to meet its specific  goals. The investment objective of  each
Portfolio described in this Prospectus is as follows:
 
    -The  EMERGING  MARKETS PORTFOLIO  seeks  long-term capital  appreciation by
     investing primarily in equity securities of emerging country issuers.
 
    -The EMERGING MARKETS DEBT  PORTFOLIO seeks high  total return by  investing
     primarily   in  debt  securities   of  government,  government-related  and
     corporate issuers located in emerging countries.
 
    -The LATIN  AMERICAN  PORTFOLIO  seeks  long-term  capital  appreciation  by
     investing  primarily in  equity securities  of Latin  American issuers and,
     from time to time, debt securities  issued or guaranteed by Latin  American
     governments or governmental entities.
 
    The  other portfolios of the Fund  are described in other prospectuses which
may be obtained from the Fund at  the address and telephone number noted on  the
cover  page  of  this  Prospectus.  The  investment  objectives  of  these other
portfolios are listed below:
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    -The  ACTIVE   COUNTRY   ALLOCATION  PORTFOLIO   seeks   long-term   capital
     appreciation  by investing in accordance with country weightings determined
     by the  Adviser in  equity securities  of non-U.S.  issuers which,  in  the
     aggregate, replicate broad country indices.
 
    -The   ASIAN  EQUITY  PORTFOLIO  seeks  long-term  capital  appreciation  by
     investing primarily in equity securities of Asian issuers.
 
    -The  ASIAN  REAL  ESTATE  PORTFOLIO  seeks  to  provide  long-term  capital
     appreciation  by investing primarily  in equity securities  of companies in
     the Asian real estate industry.
 
    -The CHINA GROWTH PORTFOLIO seeks to provide long-term capital  appreciation
     by  investing primarily  in equity  securities of  issuers in  The People's
     Republic of China, Hong Kong and Taiwan.
 
    -The EUROPEAN  EQUITY  PORTFOLIO  seeks long-term  capital  appreciation  by
     investing primarily in equity securities of European issuers.
 
    -The  EUROPEAN REAL  ESTATE PORTFOLIO  seeks to  provide current  income and
     long-term capital appreciation by investing primarily in equity  securities
     of companies in the European real estate industry.
 
    -The  GLOBAL  EQUITY  PORTFOLIO  seeks  long-term  capital  appreciation  by
     investing primarily in equity securities  of issuers throughout the  world,
     including U.S. issuers.
 
    -The  GOLD  PORTFOLIO  seeks  long-term  capital  appreciation  by investing
     primarily in equity securities of  foreign and domestic issuers engaged  in
     gold-related activities.
 
                                       8
<PAGE>
    -The  INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers.
 
    -The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation  by
     investing  primarily in equity securities  of non-U.S. issuers domiciled in
     EAFE countries.
 
    -The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital  appreciation
     by investing primarily in equity securities of non-U.S. issuers with equity
     market capitalizations of less than $1 billion.
 
    -The  JAPANESE  EQUITY  PORTFOLIO seeks  long-term  capital  appreciation by
     investing primarily in equity securities of Japanese issuers.
 
    U.S. EQUITY:
 
    -The AGGRESSIVE  EQUITY PORTFOLIO  seeks capital  appreciation by  investing
     primarily in corporate equity and equity-linked securities.
 
    -The  EMERGING  GROWTH  PORTFOLIO seeks  long-term  capital  appreciation by
     investing primarily  in  growth-oriented  equity securities  of  small-  to
     medium-sized corporations.
 
    -The  EQUITY  GROWTH  PORTFOLIO  seeks  long-term  capital  appreciation  by
     investing  in  growth-oriented  equity  securities  of  medium  and   large
     capitalization companies.
 
    -The  MICROCAP PORTFOLIO  seeks long-term capital  appreciation by investing
     primarily in growth-oriented equity securities of small corporations.
 
    -The SMALL CAP VALUE EQUITY PORTFOLIO  seeks high long-term total return  by
     investing  in  undervalued  equity  securities  of  small-  to medium-sized
     companies.
 
    -The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by  investing
     primarily  in equity  securities of companies  that, in the  opinion of the
     Portfolio's  investment  adviser,  are  expected  to  benefit  from   their
     involvement in technology and technology-related industries.
 
    -The  U.S.  EQUITY PLUS  PORTFOLIO seeks  long-term capital  appreciation by
     investing primarily in equity securities of issuers included in the S&P 500
     Index ("S&P 500").
 
    -The U.S.  REAL ESTATE  PORTFOLIO  seeks to  provide above  average  current
     income  and long-term capital appreciation by investing primarily in equity
     securities of companies in  the U.S. real  estate industry, including  real
     estate investment trusts.
 
    -The  VALUE EQUITY PORTFOLIO seeks high  total return by investing in equity
     securities which the  Adviser believes  to be undervalued  relative to  the
     stock market in general at the time of purchase.
 
    BALANCED:
 
    -The  BALANCED PORTFOLIO seeks high total return while preserving capital by
     investing in  a  combination of  undervalued  equity securities  and  fixed
     income securities.
 
    FIXED INCOME:
 
    -The  FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
     with the preservation of capital by investing in a diversified portfolio of
     fixed income securities.
 
    -The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real  rate
     of  return while preserving capital by investing in fixed income securities
     of issuers throughout the world, including U.S. issuers.
 
                                       9
<PAGE>
    -The HIGH YIELD PORTFOLIO seeks to  maximize total return by investing in  a
     diversified  portfolio of high  yield fixed income  securities that offer a
     yield above that generally available on debt securities in the four highest
     rating categories of the recognized rating services.
 
    -The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks  to produce as high a  level
     of  current income  as is  consistent with  the preservation  of capital by
     investing  primarily  in  a  variety  of  investment-grade  mortgage-backed
     securities.
 
    -The  MUNICIPAL  BOND PORTFOLIO  seeks to  produce a  high level  of current
     income consistent with preservation of principal by investing primarily  in
     municipal  obligations, the interest on which is exempt from federal income
     tax.
 
    MONEY MARKET:
 
    -The MONEY MARKET PORTFOLIO  seeks to maximize  current income and  preserve
     capital  while maintaining  high levels  of liquidity  through investing in
     high quality money market instruments with remaining maturities of one year
     or less.
 
    -The MUNICIPAL MONEY MARKET PORTFOLIO  seeks to maximize current  tax-exempt
     income  and  preserve capital  while maintaining  high levels  of liquidity
     through investing in high quality  money market instruments with  remaining
     maturities of one year or less which are exempt from federal income tax.
 
    THE  CHINA GROWTH,  MICROCAP AND  MORTGAGE-BACKED SECURITIES  PORTFOLIOS ARE
    CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management  Inc., a wholly  owned subsidiary of  Morgan
Stanley, Dean Witter, Discover & Co., acts as investment adviser to the Fund and
each  of its portfolios. As of August  31, 1997, Morgan Stanley Asset Management
Inc. and its affiliated asset management companies (exclusive of Miller Anderson
& Sherrerd, LLP, Van Kampen American Capital, Inc. and Dean Witter  InterCapital
Inc.) managed assets of approximately $80.9 billion. See "Management of the Fund
- -- Investment Adviser" and "Management of the Fund -- Administrator."
 
HOW TO INVEST
 
    Class  A shares of each  Portfolio are offered directly  to investors at net
asset value with no sales  commission or 12b-1 charges.  Class B shares of  each
Portfolio  are offered at net  asset value with no  sales commission, but with a
12b-1 fee, which  is accrued daily  and paid  quarterly, equal to  0.25% of  the
Class  B shares' average  daily net assets  on an annualized  basis. The minimum
initial investment, generally, is $500,000 for Class A shares of each  Portfolio
and  $100,000  for  Class  B  shares  of  each  Portfolio.  The  minimum initial
investment amount is reduced for certain categories of investors. For additional
information on  how to  purchase  shares and  minimum initial  investments,  see
"Purchase of Shares."
 
HOW TO REDEEM
 
    Shares  of each Portfolio may be redeemed  at any time, without cost, at the
net asset value  per share  of shares of  the applicable  class next  determined
after  receipt of the  redemption request. The  redemption price may  be more or
less than the  purchase price. Certain  redemptions that cause  the value of  an
account  to remain for  a continuous 60-day period  below the minimum investment
amount for Class A shares or for Class B shares
 
                                       10
<PAGE>
may result in involuntary redemption  or conversion. For additional  information
on  how to redeem shares and involuntary redemption or conversion, see "Purchase
of Shares --  Minimum Account Sizes  and Involuntary Redemption  of Shares"  and
"Redemption of Shares."
 
RISK FACTORS
 
    Each Portfolio invests in securities of issuers located in emerging markets.
Investing  in emerging  country securities  involves certain  considerations not
typically associated with investing in  securities of U.S. companies,  including
(i)  restrictions on foreign investment and  on repatriation of capital invested
in emerging countries, (ii) currency fluctuations, (iii) the cost of  converting
foreign  currency into U.S. dollars, (iv)  potential price volatility and lesser
liquidity of shares traded on emerging  country securities markets or lack of  a
secondary  trading market  for such  securities and  (v) political  and economic
risks, including the risk of nationalization or expropriation of assets and  the
risk  of war. In  addition, accounting, auditing,  financial and other reporting
standards in  emerging  countries  are  not equivalent  to  U.S.  standards  and
therefore,  disclosure of certain material information  may not be made and less
information may be available to  investors investing in emerging countries  than
in  the United States.  There is also generally  less governmental regulation of
the securities  industry  in  emerging  countries than  in  the  United  States.
Moreover,  it may be more difficult to obtain  a judgment in a court outside the
United States. For  temporary, defensive purposes,  when the Adviser  determines
that  market conditions  warrant, each  Portfolio may invest  up to  100% of its
assets in money  market instruments  and short-and  medium-term debt  securities
that  the Adviser believes to be of  high quality, or hold cash. See "Additional
Investment Information -- Temporary Investments."  Each Portfolio may invest  in
lower  rated debt  securities ("junk  bonds"), which  are considered speculative
with regard to the payment of  interest and return of principal. The  Portfolios
may  invest  in  certain  derivatives, including  options,  futures,  options on
futures, caps,  floors  and collars,  swaps  and structured  investments.  These
investments  entail  certain costs  and  risks, including  imperfect correlation
between the  value of  securities  held by  a Portfolio  and  the value  of  the
particular  derivative instrument, and the risk that a Portfolio could not close
out a derivatives position  when it would  be most advantageous  to do so.  Each
Portfolio   may   invest  in   depositary   receipts,  investment   funds,  loan
participations  and   assignments,  non-publicly   traded  securities,   private
placements,  restricted securities and repurchase agreements, lend its portfolio
securities and purchase securities  on a when-issued  or delayed delivery  basis
and  invest  in foreign  currency forward  contracts.  Each of  these investment
strategies  involves  specific  risks  which  are  described  under  "Investment
Objectives and Policies" and "Additional Investment Information" herein.
 
    The  Emerging Markets Portfolio  may invest in  equity securities of Russian
companies. The registration, clearing and settlement of securities  transactions
in  Russia  are  subject  to  significant  risks  not  normally  associated with
securities transactions in the United  States and other more developed  markets.
See "Additional Investment Information -- Russian Securities Transactions."
 
                                       11
<PAGE>
                       INVESTMENT OBJECTIVES AND POLICIES
 
    The investment objective of each Portfolio is described below, together with
the policies the Portfolios employ in their efforts to achieve these objectives.
Each  Portfolio's investment objective is a  fundamental policy which may not be
changed without the approval of a majority of the Portfolio's outstanding voting
securities. There  is  no  assurance  that  the  Portfolios  will  attain  their
objective.  In addition to  the investments and  strategies described below, the
Portfolios may invest  in certain  securities and  obligations as  set forth  in
"Additional  Investment Information"  below and  as described  under "Investment
Objectives and  Policies"  in  the  Statement  of  Additional  Information.  The
investment  policies described  below are  not fundamental  policies and  may be
changed without shareholder approval.
 
THE EMERGING MARKETS PORTFOLIO
 
    The investment objective of  the Portfolio is  to provide long-term  capital
appreciation  by investing  primarily in  equity securities  of emerging country
issuers. With respect  to the  Portfolio, equity securities  include common  and
preferred  stocks, convertible  securities and  rights and  warrants to purchase
common stocks. The Portfolio may also invest indirectly in equity securities  of
emerging  country issuers through depositary  receipts. Under normal conditions,
at least  65% of  the Portfolio's  total  assets will  be invested  in  emerging
country  equity  securities.  As used  in  this Prospectus,  the  term "emerging
country" applies  to  any country  which,  in the  opinion  of the  Adviser,  is
generally  considered to be  an emerging country  by the international financial
community, including the International  Bank for Reconstruction and  Development
(more   commonly  known  as  the  World  Bank)  and  the  International  Finance
Corporation. There are currently over 130 countries which, in the opinion of the
Adviser, are generally considered to be emerging or developing countries by  the
international  financial  community, approximately  40  of which  currently have
stock markets.  These countries  generally  include every  nation in  the  world
except the United States, Canada, Japan, Australia, New Zealand and most nations
located  in Western Europe.  Currently, investing in  many emerging countries is
not feasible or  may involve  unacceptable political risks.  The Portfolio  will
focus  its investments on  those emerging market countries  in which it believes
the economies are developing strongly and in which the markets are becoming more
sophisticated. The Portfolio intends to invest  primarily in some or all of  the
following countries:
 
<TABLE>
<S>                     <C>                     <C>                     <C>
Argentina               Ghana                   Malaysia                Singapore
Botswana                Greece                  Mexico                  South Africa
Brazil                  Hong Kong               Morocco                 South Korea
Bulgaria                Hungary                 Nigeria                 Sri Lanka
Chile                   India                   Pakistan                Taiwan
China                   Indonesia               Peru                    Thailand
(mainland and Hong      Israel                  Philippines             Turkey
Kong)                   Jamaica                 Poland                  Venezuela
Colombia                Jordan                  Portugal                Zimbabwe
Egypt                   Kenya                   Russia
</TABLE>
 
As  markets  in other  countries develop,  the Portfolio  expects to  expand and
further diversify the emerging countries in which it invests. The Portfolio does
not intend to  invest in any  security in a  country where the  currency is  not
freely  convertible  to  U.S. dollars,  unless  the Portfolio  has  obtained the
necessary governmental
 
                                       12
<PAGE>
licensing to convert such currency or other appropriately licensed or sanctioned
contractual  guarantees  to  protect  such  investment  against  loss  of   that
currency's  external value, or the Portfolio has a reasonable expectation at the
time  the  investment  is  made  that  such  governmental  licensing  or   other
appropriately  licensed or sanctioned  guarantees would be  obtained or that the
currency in which the security is quoted would be freely convertible at the time
of any proposed sale of the security by the Portfolio.
 
    An emerging country security is one issued by a company that, in the opinion
of the  Adviser, has  one or  more  of the  following characteristics:  (i)  its
principal securities trading market is in an emerging country, (ii) alone, or on
a consolidated basis, the company derives 50% or more of its annual revenue from
either  goods produced, sales made or  services performed in emerging countries;
or (iii) the company is organized under the laws of, and has a principal  office
in,  an emerging country. The Adviser will base determinations as to eligibility
on publicly available information and inquiries made to the companies.
 
    To the  extent that  the Portfolio's  assets are  not invested  in  emerging
country  equity securities, the remainder  of the assets may  be invested in (i)
debt securities denominated in the currency of an emerging country or issued  or
guaranteed  by  an emerging  country company  or the  government of  an emerging
country, (ii) equity  or debt  securities of corporate  or governmental  issuers
located  in  industrialized countries,  and  (iii) short-  and  medium-term debt
securities of the type described below under "Additional Investment  Information
- --  Temporary  Investments."  The Portfolio's  assets  may be  invested  in debt
securities when the Portfolio believes that, based upon factors such as relative
interest rate  levels and  foreign exchange  rates, such  debt securities  offer
opportunities  for long-term capital appreciation. It is likely that many of the
debt securities in which the Portfolio will invest will be unrated and,  whether
or  not rated, such securities may have speculative characteristics. When deemed
appropriate by the  Adviser, the Portfolio  may invest  up to 20%  of its  total
assets  (measured  at  the  time  of  the  investment)  in  lower  quality  debt
securities. Lower quality debt securities, also known as "junk bonds," are often
considered to  be speculative  and  involve greater  risk  of default  or  price
changes  due to changes in the issuer's creditworthiness. As of the date of this
prospectus, less than 5% of the  Portfolio's total assets were invested in  junk
bonds.  The market prices of  these securities may fluctuate  more than those of
higher quality securities and  may decline significantly  in periods of  general
economic  difficulty,  which  may  follow  periods  of  rising  interest  rates.
Securities in the lowest  quality category may present  the risk of default,  or
may be in default.
 
THE EMERGING MARKETS DEBT PORTFOLIO
 
    The  investment objective of the Portfolio is  to seek high total return. In
seeking to achieve this  objective, the Portfolio will  seek to invest at  least
65%  of its total assets in debt securities of government and government-related
issuers located in emerging countries (including participations in loans between
governments  and  financial   institutions),  and  of   entities  organized   to
restructure  outstanding debt  of such issuers.  In addition,  the Portfolio may
invest up to 35%  of its total  assets in debt  securities of corporate  issuers
located  in or organized under the laws of emerging countries. See "The Emerging
Markets Portfolio" above for a definition of emerging countries.
 
                                       13
<PAGE>
    The Adviser intends  to invest  the Portfolio's assets  in emerging  country
debt  securities that provide a high level  of current income, while at the same
time  holding  the   potential  for  capital   appreciation  if  the   perceived
creditworthiness  of the issuer  improves due to  improving economic, financial,
political, social or  other conditions  in the country  in which  the issuer  is
located.  Currently,  investing  in  many  emerging  country  securities  is not
feasible or may involve unacceptable  political risks. Initially, the  Portfolio
expects  that its investments  in emerging country debt  securities will be made
primarily in some or all of the following emerging countries:
 
<TABLE>
<S>                     <C>                     <C>
Algeria                 Hungary                 Peru
Argentina               India                   Philippine
Brazil                  Indonesia               Poland
Bulgaria                Ivory Coast             Portugal
Chile                   Jamaica                 Russia
China                   Jordan                  Slovakia
Colombia                Malaysia                South Africa
Costa Rica              Mexico                  Thailand
Czech Republic          Morocco                 Trinidad & Tobago
Democratic Republic of
Congo                   Nicaragua               Tunisia
Dominican Republic      Nigeria                 Turkey
Ecuador                 Pakistan                Uruguay
Egypt                   Panama                  Venezuela
Greece                  Paraguay
</TABLE>
 
As opportunities to invest  in debt securities in  other countries develop,  the
Portfolio  expects to  expand and  further diversify  the emerging  countries in
which it invests. While the Portfolio generally is not restricted in the portion
of its  assets which  may be  invested  in a  single country  or region,  it  is
anticipated  that,  under  normal  conditions, the  Portfolio's  assets  will be
invested in issuers in at least three countries.
 
    Emerging country debt securities  that the Portfolio  may invest in  include
bonds,  notes, bills,  debentures, convertible  securities, warrants,  bank debt
obligations, short-term paper, mortgage and other asset-backed securities,  loan
participations,  loan assignments and interests issued by entities organized and
operated for  the purpose  of restructuring  the investment  characteristics  of
instruments issued by emerging country issuers. U.S. dollar-denominated emerging
country  debt securities held by the Portfolio  will generally be listed but not
traded on a securities exchange, and non-U.S. dollar-denominated securities held
by the Portfolio may or  may not be listed or  traded on a securities  exchange.
The  Portfolio  will be  subject to  no  restrictions on  the maturities  of the
emerging country  debt securities  it  holds; those  maturities may  range  from
overnight to 30 years.
 
    The  Portfolio is not restricted  in the portion of  its assets which may be
invested in securities denominated  in a particular  currency and a  substantial
portion of the Portfolio's assets may be invested in non-U.S. dollar-denominated
securities.  The  portion  of  the  Portfolio's  assets  invested  in securities
denominated in currencies  other than  the U.S.  dollar will  vary depending  on
market  conditions.  Although the  Portfolio is  permitted to  engage in  a wide
variety of investment practices designed to hedge against currency exchange rate
risks  with  respect  to  its  holdings  of  non-U.S.  dollar-denominated   debt
securities,  the Portfolio may be limited in  its ability to hedge against these
risks.
 
                                       14
<PAGE>
    In selecting particular emerging country  debt securities for investment  by
the  Portfolio,  the Adviser  will apply  a  market risk  analysis contemplating
assessment of factors such as liquidity, volatility, tax implications,  interest
rate  sensitivity,  counterparty  risks  and  technical  market  considerations.
Emerging country  debt securities  in which  the Portfolio  may invest  will  be
subject  to high risk and will not be required to meet a minimum rating standard
and may  not be  rated for  creditworthiness by  any internationally  recognized
credit rating organization. The Portfolio's investments are expected to be rated
in  the lower and lowest rating  categories of internationally recognized credit
rating organizations  or are  expected to  be unrated  securities of  comparable
quality.  These  types of  debt obligations  are predominantly  speculative with
respect to the capacity to pay  interest and repay principal in accordance  with
their terms and generally involve a greater risk of default and of volatility in
price  than securities  in higher  rating categories.  Ratings of  non-U.S. debt
instruments, to the extent undertaken, are related to evaluations of the country
in which the issuer of the instrument is located and generally take into account
the currency in  which a  non-U.S. debt instrument  is denominated.  Instruments
issued  by a foreign government in other than the local currency, typically have
a lower  rating  than  local currency  instruments  due  to the  risk  that  the
government will be unable to obtain the required foreign currency to service its
foreign currency-denominated debt. In general, the ratings of debt securities or
obligations  issued by a  non-U.S. public or  private entity will  not be higher
than the rating  of the currency  or the  foreign currency debt  of the  central
government  of the  country in  which the issuer  is located,  regardless of the
intrinsic creditworthiness of the issuer.
 
    The  Portfolio's   investments   in   government,   government-related   and
restructured  debt securities will consist of (i) debt securities or obligations
issued or guaranteed by governments, governmental agencies or  instrumentalities
and   political   subdivisions   located   in   emerging   countries   including
participations in  loans between  governments and  financial institutions,  (ii)
debt  securities  or  obligations  issued  by  government  owned,  controlled or
sponsored  entities  located  in  emerging  countries,  and  (iii)  issuers   of
structured  securities.  Certain issuers  of such  structured securities  may be
deemed to be "investment companies" as defined in the Investment Company Act  of
1940,  as amended (the "1940  Act"). As a result,  the Portfolio's investment in
such securities may be limited  by certain investment restrictions contained  in
the  1940 Act. The Portfolio's investments in government, government-related and
restructured debt  instruments  are  subject to  special  risks,  including  the
inability  or  unwillingness  to  repay  principal  and  interest,  requests  to
reschedule or restructure  outstanding debt  and requests  to extend  additional
loan amounts. The Portfolio may have limited recourse in the event of default on
such debt instruments.
 
    The  Portfolio's  investments in  debt  securities of  corporate  issuers in
emerging countries  may include  debt securities  or obligations  issued (i)  by
banks  located in  emerging countries or  by branches of  emerging country banks
located outside the country or (ii) by companies organized under the laws of  an
emerging  country. Determinations as to eligibility  will be made by the Adviser
based on publicly available  information and inquiries made  to the issuer.  The
Portfolio may also invest in certain debt obligations customarily referred to as
"Brady  Bonds," which  are created through  the exchange  of existing commercial
bank loans  to foreign  entities for  new obligations  in connection  with  debt
restructurings  under a plan introduced by former U.S. Secretary of the Treasury
Nicholas F. Brady.
 
    The Portfolio  may  also invest  in  zero coupon,  pay-in-kind  or  deferred
payment  securities and in securities that  may be collateralized by zero coupon
securities  (such  as  Brady  Bonds).  Zero  coupon  securities  are  securities
 
                                       15
<PAGE>
that  are sold at a discount to par value and on which interest payments are not
made during the life of the security.  Upon maturity, the holder is entitled  to
receive  the par value of the security.  While interest payments are not made on
such securities, the Portfolio accrues income, or "Phantom Income," with respect
to these securities prior  to the receipt of  cash payments. The Portfolio  will
distribute  its  "phantom  income"  to  shareholders  and,  to  the  extent that
shareholders elect to  receive dividends  in cash rather  than reinvesting  such
dividends  in additional shares, the Portfolio  will have fewer assets available
to purchase income producing securities. Pay-in-kind securities pay interest  by
delivery  of additional  securities. Upon  maturity, the  holder is  entitled to
receive the aggregate par value  of the securities. Deferred payment  securities
remain  zero coupon  securities until  a predetermined  date, at  which time the
stated coupon rate  becomes effective  and interest becomes  payable at  regular
intervals.  Zero  coupon, pay-in-kind  and  deferred payment  securities  may be
subject to greater  fluctuation in value  and lesser liquidity  in the event  of
adverse  market  conditions  than  comparably  rated  securities  that  pay cash
interest at regular interest payment periods.
 
    The  Portfolio  may  also   invest  up  to  5%   of  its  total  assets   in
mortgage-backed  securities  and  in  other  asset-backed  securities  issued by
non-governmental entities,  such  as  banks and  other  financial  institutions.
Mortgage-backed   securities  include   mortgage  pass-through   securities  and
collateralized mortgage obligations. Asset-backed securities are  collateralized
by  such assets  as automobile  or credit  card receivables  and are securitized
either in a pass-through  structure or in a  pay-through structure similar to  a
CMO.
 
THE LATIN AMERICAN PORTFOLIO
 
    The  investment  objective  of  the Latin  American  Portfolio  is long-term
capital appreciation. The Portfolio seeks to achieve this objective by investing
primarily in equity securities  (i) of companies organized  in or for which  the
principal  securities trading market is in  Latin America, (ii) denominated in a
Latin American currency and issued by  companies to finance operations in  Latin
America,  or (iii) of companies that alone or on a consolidated basis derive 50%
or more  of their  annual revenues  from either  goods produced,  sales made  or
services performed in Latin America (collectively, "Latin American issuers") and
by  investing, from time to  time, in debt securities  issued or guaranteed by a
Latin American  government  or  governmental entity.  Under  normal  conditions,
substantially  all, but not less  than 80%, of the  Portfolio's total assets are
invested in equity securities of Latin  American issuers and in debt  securities
issued  or guaranteed by a Latin American government or governmental entity. For
purposes of this Prospectus, unless otherwise indicated, Latin America  consists
of  Argentina, Bolivia, Brazil, Chile, Colombia, Costa Rica, Cuba, the Dominican
Republic, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua,  Panama,
Paraguay, Peru, Uruguay and Venezuela.
 
    The  Portfolio  focuses  its  investments  in  listed  equity  securities in
Argentina, Brazil, Chile and Mexico, the most developed capital markets in Latin
America. The Portfolio expects, under normal market conditions, to have at least
55% of its total assets invested in listed equity securities of issuers in these
four countries. The  Portfolio is  not limited  in the  extent to  which it  may
invest  in any Latin American country and intends to invest opportunistically as
markets develop. The portion of the  Portfolio's holdings in any Latin  American
country  will vary from  time to time,  although the portion  of the Portfolio's
assets invested in Chile  may tend to  vary less than  the portions invested  in
other  Latin  American  countries  because,  with  limited  exceptions,  capital
invested  in  Chile  currently  cannot  be  repatriated  for  one  year.  Equity
securities  in which  the Portfolio  may invest  include those  that are neither
listed on  a stock  exchange nor  traded over-the-counter.  As a  result of  the
absence of a public trading market for these securities, they may be less liquid
than publicly traded securities.
 
                                       16
<PAGE>
    The  governments  of  some Latin  American  countries have  been  engaged in
programs of  selling  part  or  all  of their  stakes  in  government  owned  or
controlled   enterprises   ("privatizations").   The   Adviser   believes   that
privatizations  may  offer  investors  opportunities  for  significant   capital
appreciation  and intends to invest assets of the Portfolio in privatizations in
appropriate circumstances. In certain Latin  American countries, the ability  of
foreign entities, such as the Portfolio, to participate in privatizations may be
limited  by local law, or  the terms on which the  Portfolio may be permitted to
participate may be less advantageous than  those for local investors. There  can
be  no assurance that Latin American governments will continue to sell companies
currently owned or  controlled by  them or  that any  privatization programs  in
which the Portfolio participates will be successful.
 
    The  Portfolio may participate in debt to equity conversion programs adopted
by several  Latin  American  countries,  pursuant to  which  investors  may  use
government issued or guaranteed debt securities, directly or indirectly, to make
investments  in local  companies. The  terms of  the various  programs vary from
country to country  although each program  includes significant restrictions  on
the application of the proceeds received in the conversion and on the remittance
of  profits on  the investment  and of  the invested  capital. The  Adviser will
evaluate opportunities to enter into  debt to equity conversion transactions  as
they arise.
 
    To  the  extent  that the  Portfolio's  assets  are not  invested  in equity
securities of Latin American issuers or in government issued or guaranteed  debt
securities,  the remainder of its assets may  be invested in (i) debt securities
of other Latin American issuers, (ii) equity or debt securities of corporate  or
governmental  issuers  located in  countries  outside Latin  America,  and (iii)
short-term  and  medium-term  debt  securities  of  the  type  described   under
"Additional   Investment  Information  --   Temporary  Investments"  below.  The
Portfolio's assets  may  be  invested  in debt  securities  when  the  Portfolio
believes  that, based  upon factors  such as  relative interest  rate levels and
foreign exchange  rates,  debt  securities  offer  opportunities  for  long-term
capital appreciation. It is likely that many of the debt securities in which the
Portfolio will invest will be unrated. The Portfolio may invest up to 20% of its
total assets in lower-quality debt securities that are determined by the Adviser
to  be comparable to securities  rated below investment grade  by S&P or Moody's
("junk bonds"). Investment  in such debt  securities involves a  high degree  of
risk  and is generally  considered to be speculative  in nature. See "Additional
Investment Information -- Lower Rated Debt Securities."
 
    The Portfolio will  not invest  more than  25% of  its total  assets in  one
industry  except, and to  the extent, and only  for such period  of time, as the
Board of Directors determines that it  is appropriate and in the best  interests
of the Portfolio and its shareholders to invest more than 25% of the Portfolio's
total  assets  in  companies  involved  in  each  of  the  telecommunications or
financial services  industries. Concentration  in these  two industries  may  be
beneficial  to the  Portfolio because the  securities markets  of Latin American
countries are emerging  markets characterized  by a relatively  small number  of
issuers  and it is possible that one or  more markets may be dominated by issues
of companies in these  industries. Also, it is  possible that Privatizations  in
certain  Latin American countries which currently  represent a primary source of
new issues in many  Latin American markets and  are often attractive  investment
opportunities will occur in these two industries.
 
    The  Board  of Directors  has  determined that,  in  light of  the increased
presence of  telecommunications companies  in the  Latin American  markets,  the
Portfolio's  ability  to achieve  its investment  objective would  be materially
adversely affected if  it were  not permitted  to invest  more than  25% of  its
assets  in securities of  companies in the  telecommunications industries of the
Latin American countries in which the Portfolio invests.
 
                                       17
<PAGE>
In accordance with the  Portfolio's investment restrictions and  as a result  of
the  Board's action,  the Portfolio is  required to  invest at least  25% of its
total  assets  in  securities   of  Latin  American   issuers  engaged  in   the
telecommunications  industry. The  Portfolio will  remain so  invested until the
Board determines that the Portfolio should invest less than 25% of its assets in
that industry. Because the Portfolio will  have a more concentrated position  in
the  securities of a single sector within the Latin American securities markets,
the Portfolio will be subject to  certain risks with respect to these  portfolio
securities.  Market price  movements affecting  telecommunications companies and
their securities  will have  a  greater impact  on the  Portfolio's  performance
because of the more concentrated position in such securities. Telecommunications
may  be subject  to greater  government regulation  than many  other industries.
Changes in government policies and the  need to obtain regulatory approvals  may
have  a material effect  on products and  services offered by telecommunications
companies. Technological and  structural developments may  adversely affect  the
profitability of telecommunications companies. To better control the Portfolio's
exposure  to such risks, the Board has limited investments in telecommunications
securities to not more than 40% of the Portfolio's assets.
 
    The Board of Directors has not currently authorized the Portfolio to  invest
more  than  25% of  its total  assets  in the  financial services  industry. The
Portfolio will notify shareholders of any decision by the Board of Directors  to
permit  investments  of  more  than  25%  in  the  financial  services  industry
including, if  applicable,  a  discussion  of  any  increased  investment  risks
particular to this industry to which the Portfolio may be exposed.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    BORROWING  AND OTHER FORMS OF LEVERAGE.  The Emerging Markets Debt and Latin
American Portfolios are authorized to borrow money from banks and other entities
in an amount up to 33 1/3% of the Portfolios' total assets (including the amount
borrowed) less all liabilities  and indebtedness other  than the borrowing,  and
may  use  the  proceeds of  the  borrowing  for investment  purposes  or  to pay
dividends. Borrowing  for  investment  purposes  creates  leverage  which  is  a
speculative  characteristic. Although  the Portfolios are  authorized to borrow,
they will do so only when the  Adviser believes that borrowing will benefit  the
Portfolios  after taking  into account considerations  such as the  costs of the
borrowing and  the  likely  investment  returns  on  securities  purchased  with
borrowed  monies. Borrowing  by the Portfolios  will create  the opportunity for
increased  net  income  but,  at  the  same  time,  will  involve  special  risk
considerations.  Leverage that results  from borrowing will  magnify declines as
well as increases in the Portfolios' net asset value per share and net yield.
 
    The Portfolios expect that all of their borrowing will be made on a  secured
basis.  The Portfolios' Custodian will either  segregate the assets securing the
borrowing for the benefit  of the lenders  or arrangements will  be made with  a
suitable  sub-custodian.  If assets  used to  secure  the borrowing  decrease in
value, the Portfolios  may be required  to pledge additional  collateral to  the
lender in the form of cash or securities to avoid liquidation of those assets.
 
    DEPOSITARY  RECEIPTS.   The  Portfolios may  invest in  Depositary Receipts,
including American  Depositary  Receipts ("ADRs"),  Global  Depositary  Receipts
("GDRs"),  European Depositary  Receipts ("EDRs") and  other Depositary Receipts
(which, together with ADRs, GDRs and EDRs, are hereinafter collectively referred
to as "Depositary Receipts"), to the extent that such Depositary Receipts are or
become available.  ADRs are  securities, typically  issued by  a U.S.  financial
institution   (a  "depositary"),   that  evidence   ownership  interests   in  a
 
                                       18
<PAGE>
security or a  pool of securities  issued by a  foreign issuer (the  "underlying
issuer")  and deposited  with the  depositary. ADRs  include American Depositary
Shares and New York  Shares and may be  "sponsored" or "unsponsored."  Sponsored
ADRs  are established jointly by a depositary and the underlying issuer, whereas
unsponsored ADRs may be established by a depositary without participation by the
underlying issuer.  The  issuers  of  the stock  of  unsponsored  ADRs  are  not
obligated  to disclose material information in  the United States and therefore,
there may not be a correlation between such information and the market value  of
the  ADR. GDRs, EDRs and other types of Depositary Receipts are typically issued
by foreign depositaries, although they may also be issued by U.S.  depositaries,
and  evidence ownership interests in a security  or pool of securities issued by
either a  foreign  or a  U.S.  corporation. Generally,  Depositary  Receipts  in
registered  form  are  designed  for  use  in  the  U.S.  securities  market and
Depositary Receipts in bearer  form are designed for  use in securities  markets
outside   the  United  States.  The  Portfolios  may  invest  in  sponsored  and
unsponsored Depositary  Receipts. For  purposes  of the  Portfolios'  investment
policies,  the Portfolios' investments in Depositary  Receipts will be deemed to
be investments in the underlying securities.
 
    FOREIGN CURRENCY FORWARD CONTRACTS.   The Portfolios may enter into  foreign
currency  forward contracts ("forward contracts")  that provide for the purchase
or sale of an amount  of a specified currency at  a future date. The  Portfolios
may  use  such contracts  to protect  against  a decline  in a  foreign currency
against the U.S.  dollar between  the trade date  and settlement  date when  the
Portfolio  purchases  or sells  securities,  lock in  the  U.S. dollar  value of
dividends and interest  on securities held  by the Portfolio,  and generally  to
protect  the  U.S. dollar  value  of securities  held  by the  Portfolio against
exchange rate fluctuation. While forward contracts may limit losses as a  result
of  exchange  rate  fluctuations, they  will  also  limit any  gains  that might
otherwise have been realized. The Portfolio's Custodian may be required to place
cash or liquid  securities in a  segregated account  in an amount  equal to  the
value  of the Portfolio's total assets  committed to the consummation of forward
contracts. If  the value  of the  securities placed  in the  segregated  account
declines, additional cash or securities will be placed in the account on a daily
basis  so that the value of the account will  be at least equal to the amount of
the Portfolio's commitments with respect to such contracts.
 
    FOREIGN INVESTMENT.   Investment in securities  of foreign issuers  involves
somewhat  different  investment risks  than those  affecting securities  of U.S.
domestic issuers.  There  may be  limited  publicly available  information  with
respect  to foreign  issuers, and foreign  issuers are not  generally subject to
uniform accounting, auditing  and financial  and other  reporting standards  and
requirements comparable to those applicable to U.S. companies. There may also be
less  government  supervision and  regulation  of foreign  securities exchanges,
brokers and listed companies than in the United States. Many foreign  securities
markets  have substantially less volume than U.S. national securities exchanges,
and securities of some  foreign issuers are less  liquid and more volatile  than
securities  of  comparable  domestic issuers.  Brokerage  commissions  and other
transaction costs on foreign securities  exchanges are generally higher than  in
the United States. Dividends and interest paid by foreign issuers may be subject
to  withholding and other  foreign taxes, which  may decrease the  net return on
foreign investments  as compared  to  dividends and  interest paid  by  domestic
companies.  Additional risks include future political and economic developments,
the possibility that a foreign  jurisdiction might impose or change  withholding
taxes  on income payable  with respect to  foreign securities, possible seizure,
nationalization or expropriation of the  foreign issuer or foreign deposits  and
the  possible  adoption of  foreign governmental  restrictions such  as exchange
controls.
 
                                       19
<PAGE>
    Prior governmental approval  for foreign investments  may be required  under
certain  circumstances in  some emerging  countries, and  the extent  of foreign
investment in certain debt securities and  domestic companies may be subject  to
limitation  in other emerging countries.  Foreign ownership limitations also may
be imposed by  the charters  of individual  companies in  emerging countries  to
prevent, among other concerns, violation of foreign investment limitations.
 
    Repatriation  of investment  income, capital  and the  proceeds of  sales by
foreign investors may require governmental registration and/or approval in  some
emerging  countries. The Portfolios could be adversely affected by delays in, or
a refusal to grant, any required governmental registration or approval for  such
repatriation.  Any  investment subject  to  such repatriation  controls  will be
considered illiquid if it appears reasonably likely that this process will  take
more than seven days.
 
    The  economies  of individual  emerging  countries may  differ  favorably or
unfavorably from the U.S. economy in  such respects as growth of gross  domestic
product,   rate  of  inflation,  currency  depreciation,  capital  reinvestment,
resource  self-sufficiency  and  balance  of  payments  position.  Further,  the
economies   of  emerging   countries  generally   are  heavily   dependent  upon
international trade  and,  accordingly,  have  been, and  may  continue  to  be,
adversely  affected by trade barriers, exchange controls, managed adjustments in
relative currency values and other protectionist measures imposed or  negotiated
by  the countries with which they trade. These economies also have been, and may
continue to be, adversely affected by economic conditions in the countries  with
which they trade.
 
    With   respect  to  any  emerging  country,  there  is  the  possibility  of
nationalization, expropriation  or  confiscatory  taxation,  political  changes,
government  regulation, social instability or diplomatic developments (including
war) which could affect adversely the  economies of such countries or the  value
of  each  Portfolio's investments  in those  countries. In  addition, it  may be
difficult to obtain  and enforce a  judgment in  a court outside  of the  United
States.
 
    Investments  in securities of foreign  issuers are frequently denominated in
foreign currencies, and because each  Portfolio may temporarily hold  uninvested
reserves  in bank deposits in foreign  currencies, the value of each Portfolio's
assets, as measured in U.S. dollars, may be affected favorably or unfavorably by
changes in currency rates and in exchange control regulations and the Portfolios
may incur costs in connection with conversions between various currencies.
 
    INVESTMENT FUNDS.  Some  emerging countries have  laws and regulations  that
currently  preclude  direct  foreign  investment  in  the  securities  of  their
companies. However, indirect foreign investment  in the securities of  companies
listed  and traded  on the  stock exchanges in  these countries  is permitted by
certain emerging countries through investment funds which have been specifically
authorized. The Portfolios may invest in  these investment funds subject to  the
provisions  of the 1940 Act  and other applicable laws  as discussed below under
"Investment Restrictions." If a Portfolio invests in such investment funds,  the
Portfolio's  shareholders will  bear not only  their proportionate  share of the
expenses of the  Portfolio (including  operating expenses  and the  fees of  the
Adviser),  but  also will  indirectly bear  similar  expenses of  the underlying
investment funds.
 
                                       20
<PAGE>
    Certain  of the investment funds referred  to in the preceding paragraph are
advised by the Adviser. These Portfolios may, to the extent permitted under  the
1940  Act  and other  applicable law,  invest  in these  investment funds.  If a
Portfolio does elect to make an investment  in such an investment fund, it  will
only purchase the securities of such investment fund in the secondary market.
 
    LOAN  PARTICIPATIONS AND  ASSIGNMENTS.  The  Portfolios may  invest in fixed
rate and floating  rate loans  ("Loans") arranged  through private  negotiations
between  an  issuer of  sovereign  debt obligations  and  one or  more financial
institutions ("Lenders"). The Portfolios' investments  in Loans are expected  in
most  instances to be  in the form of  participation in Loans ("Participations")
and assignments of all or a portion of Loans ("Assignments") from third parties.
The Portfolios will have  the right to receive  payments of principal,  interest
and  any  fees  to  which  it  is entitled  only  from  the  Lender  selling the
Participation and  only upon  receipt by  the Lender  of the  payments from  the
borrower.  In the event of the insolvency of the Lender selling a Participation,
the Portfolios may be treated  as a general creditor of  the Lender and may  not
benefit   from  any  set-off  between  the  Lender  and  the  borrower.  Certain
Participations may be  structured in a  manner designed to  avoid purchasers  of
Participations  being subject to the  credit risk of the  Lender with respect to
the Participation. Even  under such a  structure, in the  event of the  Lender's
insolvency,  the Lender's servicing of the  Participation may be delayed and the
assignability of the Participation may be impaired. The Portfolios will  acquire
Participations only if the Lender interpositioned between the Portfolios and the
borrower is determined by the Adviser to be creditworthy.
 
    When  the  Portfolios purchase  Assignments from  Lenders they  will acquire
direct rights against the borrower on the Loan. However, because Assignments are
arranged through private negotiations between potential assignees and  potential
assignors,  the  rights  and  obligations  acquired  by  the  Portfolios  as the
purchaser of an Assignment may differ from, and be more limited than, those held
by the assigning Lender. Because there is no liquid market for such  securities,
the  Portfolios anticipate that such securities could  be sold only to a limited
number of institutional  investors. The lack  of a liquid  secondary market  may
have  an adverse  impact on  the value  of such  securities and  the Portfolios'
ability to dispose of particular Assignments or Participations when
necessary to meet the Portfolios' liquidity  needs or in response to a  specific
economic  event such as a deterioration in the creditworthiness of the borrower.
The lack of a  liquid secondary market for  Assignments and Participations  also
may  make  it more  difficult  for the  Portfolios to  assign  a value  to these
securities for purposes  of valuing  the Portfolios'  portfolio and  calculating
their net asset value.
 
    LOANS  OF  PORTFOLIO  SECURITIES.   The  Portfolios may  lend  securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose  of increasing  their net  investment income.  These loans  must  be
secured  continuously by cash or equivalent collateral, or by a letter of credit
at least  equal  to the  market  value of  the  securities loaned  plus  accrued
interest  or income. There may be a risk  of delay in recovery of the securities
or even loss of rights in the  collateral should the borrower of the  securities
fail   financially.  Each  Portfolio   will  not  enter   into  securities  loan
transactions exceeding in the aggregate 33 1/3% of the market value of its total
assets.
 
    LOWER RATED DEBT SECURITIES.   Each Portfolio may  invest in lower rated  or
unrated  debt securities, commonly referred to as "junk bonds." In addition, the
emerging country debt securities in which the Portfolios may invest will not  be
required  to meet a minimum  rating standard and may  not be rated. Fixed income
securities are subject to  the risk of an  issuer's inability to meet  principal
and  interest payments on the obligations (credit  risk) and may also be subject
to price volatility  due to such  factors as interest  rate sensitivity,  market
 
                                       21
<PAGE>
perception  of the creditworthiness  of the issuer  and general market liquidity
(market risk). Lower  rated or unrated  securities are more  likely to react  to
developments  affecting  market  and  credit risk  than  are  more  highly rated
securities, which react primarily to movements in the general level of  interest
rates.  The market values of fixed-income securities tend to vary inversely with
the level of interest rates. Yields and market values of lower rated and unrated
debt securities will fluctuate over time, reflecting not only changing  interest
rates but the market's perception of credit quality and the outlook for economic
growth.  When economic  conditions appear to  be deteriorating,  medium to lower
rated securities may  decline in  value due  to heightened  concern over  credit
quality,  regardless of prevailing interest rates.  Fluctuations in the value of
the Portfolio's investments will be reflected in the Portfolio's net asset value
per share. The  Adviser considers  both credit risk  and market  risk in  making
investment decisions for the Portfolios. Investors should carefully consider the
relative  risks  of investing  in lower  rated and  unrated debt  securities and
understand  that  such  securities  are  not  generally  meant  for   short-term
investing.
 
    The market for lower rated and unrated debt securities is relatively new and
adverse economic developments may disrupt the market for lower rated and unrated
emerging  country  debt securities.  Such  disruptions may  severely  affect the
ability of issuers, especially highly  leveraged issuers, to service their  debt
obligations  or  to  repay their  obligations  upon maturity.  In  addition, the
secondary  market  for  lower  rated  and  unrated  debt  securities,  which  is
concentrated  in  relatively few  market makers,  may  not be  as liquid  as the
secondary market for  more highly  rated securities.  As a  result, the  Adviser
could find it more difficult to sell these securities or may be able to sell the
securities  only at prices lower than if  such securities were widely traded. In
addition there may  be limited trading  markets for debt  securities of  issuers
located in emerging countries. Prices realized upon the sale of such lower rated
or  unrated securities, under  these circumstances, may be  less than the prices
used in calculating a Portfolio's net asset value.
 
    Lower rated or unrated debt obligations also present risks based on  payment
expectations. If an issuer calls the obligations for redemption, a Portfolio may
have  to replace  the security  with a lower  yielding security,  resulting in a
decreased return  for  investors.  If a  Portfolio  experiences  unexpected  net
redemptions,  it may be forced to sell its higher rated securities, resulting in
a decline in the overall credit quality of the Portfolio's investment  portfolio
and  increasing the exposure  of the Portfolio  to the risks  of lower rated and
unrated debt securities.
 
    MONEY MARKET INSTRUMENTS.   Each Portfolio is permitted  to invest in  money
market  instruments,  although  each  Portfolio  intends  to  stay  invested  in
securities satisfying its primary investment objective to the extent  practical.
Consistent  with their investment policies, the Portfolios may make money market
investments pending other investment or  settlement for liquidity. In  addition,
the  Portfolios may invest  in money market  instruments for temporary defensive
purposes during  adverse market  conditions.  See "Temporary  Investments."  The
money market investments permitted for the Portfolios include obligations of the
U.S.  government and its agencies  and instrumentalities; obligations of foreign
sovereignties;  other  debt  securities;  commercial  paper;  bank  obligations;
certificates  of  deposit (including  Eurodollar  certificates of  deposit); and
repurchase agreements.
 
    NON-PUBLICLY  TRADED   SECURITIES,   PRIVATE   PLACEMENTS   AND   RESTRICTED
SECURITIES.   The Portfolios may invest in securities that are neither listed on
a  stock  exchange  nor  traded  over-the-counter,  including  privately  placed
securities.  Investing  in  such unlisted  emerging  country  equity securities,
including investments  in new  and early  stage companies,  may involve  a  high
degree   of  business  and  financial  risk   that  can  result  in  substantial
 
                                       22
<PAGE>
losses. As  a  result of  the  absence of  a  public trading  market  for  these
securities,  they may be  less liquid than  publicly traded securities. Although
these securities may be resold in privately negotiated transactions, the  prices
realized  from  these sales  could be  less  than those  originally paid  by the
Portfolios or  less  than  what  may  be  considered  the  fair  value  of  such
securities.  Further, companies whose securities are not publicly traded may not
be subject to the  disclosure and other  investor protection requirements  which
might be applicable if their securities were publicly traded. If such securities
are  required  to  be  registered  under the  securities  laws  of  one  or more
jurisdictions before being resold,  the Portfolios may be  required to bear  the
expenses of registration.
 
    As  a general matter, each Portfolio may not invest more than 15% of its net
assets in  illiquid  securities, including  securities  for which  there  is  no
readily available secondary market. Nor, as a general matter, may each Portfolio
invest  more than 10% of its total assets in securities that are restricted from
sale to  the public  without registration  ("Restricted Securities")  under  the
Securities  Act of 1933 (the "1933 Act").  However, each Portfolio may invest up
to 25% of its total assets in  liquid Restricted Securities that can be  offered
and  sold to qualified institutional  buyers under Rule 144A  under the 1933 Act
("Rule 144A  Securities"). The  Board of  Directors has  adopted guidelines  and
delegated  to the Adviser, subject to the supervision of the Board of Directors,
the daily function  of determining  and monitoring  the liquidity  of Rule  144A
Securities.  Rule 144A securities may become illiquid if qualified institutional
buyers are not interested in acquiring the securities.
 
    REPURCHASE AGREEMENTS.  Each Portfolio may enter into repurchase  agreements
with  brokers, dealers or  banks that meet the  credit guidelines established by
the Fund's Board of Directors. In  a repurchase agreement, the Portfolio buys  a
security  from a seller  that has agreed  to repurchase it  at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of  the
agreement.  The term of these agreements is  usually from overnight to one week,
and never  exceeds one  year. Repurchase  agreements may  be viewed  as a  fully
collateralized  loan  of money  by the  Portfolio to  the seller.  The Portfolio
always receives securities with  a market value at  least equal to the  purchase
price  (including accrued interest) as collateral,  and this value is maintained
during the term  of the  agreement. If the  seller defaults  and the  collateral
value  declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with  respect to  the  seller, the  Portfolio's realization  upon  the
collateral  may  be  delayed  or  limited. The  Portfolios  may  not  enter into
repurchase agreements with  more than seven  days to maturity  if, as a  result,
more  than  15% of  the  market value  of the  Portfolio's  net assets  would be
invested in such repurchase agreements and in other investments for which market
quotations are not readily available or which are otherwise illiquid.
 
    REVERSE REPURCHASE  AGREEMENTS.   The Emerging  Markets Debt  Portfolio  may
enter  into reverse  repurchase agreements  with brokers,  dealers, domestic and
foreign  banks  or  other  financial  institutions.  In  a  reverse   repurchase
agreement,  the Portfolio  sells a  security and  agrees to  repurchase it  at a
mutually agreed upon date and price, reflecting the interest rate effective  for
the  term of the agreement. It  may also be viewed as  the borrowing of money by
the  Portfolio.  The  Portfolio's  investment  of  the  proceeds  of  a  reverse
repurchase  agreement is the speculative factor known as leverage. The Portfolio
may enter into a reverse repurchase  agreement only if the interest income  from
investment  of  the  proceeds  is  greater  than  the  interest  expense  of the
transaction and the proceeds are invested for  a period no longer than the  term
of  the agreement.  The Portfolio  will maintain  with the  Custodian a separate
account with a  segregated portfolio of  cash or other  liquid securities in  an
amount  at  least  equal to  its  purchase obligations  under  these agreements.
Reverse repurchase agreements are considered to be borrowings and are subject to
the percentage limitations on borrowings set forth in "Borrowing and Other Forms
of Leverage."
 
                                       23
<PAGE>
    RUSSIAN SECURITIES TRANSACTIONS.  The Emerging Markets Portfolio may  invest
in  equity  securities  of  Russian  issuers.  The  registration,  clearing  and
settlement of securities transactions in Russia are subject to significant risks
not normally associated with  securities transactions in  the United States  and
other  more  developed  markets. Ownership  of  shares in  Russian  companies is
evidenced by entries in a company's share register (except where shares are held
through depositories  that  meet the  requirements  of  the 1940  Act)  and  the
issuance  of extracts from the register or,  in certain limited cases, by formal
share certificates. However, Russian  share registers are frequently  unreliable
and  the  Portfolio  could  possibly lose  its  registration  through oversight,
negligence or fraud.  Moreover, Russia  lacks a centralized  registry to  record
securities   transactions  and  registrars  located  throughout  Russia  or  the
companies  themselves  maintain  share   registers.  Registrars  are  under   no
obligation  to provide extracts to potential purchasers in a timely manner or at
all and are not necessarily subject to effective state supervision. In addition,
while registrars are liable under law for losses resulting from their errors, it
may be difficult for the Portfolio to enforce any rights it may have against the
registrar  or  issuer  of  the  securities  in  the  event  of  loss  of   share
registration.  Although Russian companies with  more than 1,000 shareholders are
required by law to employ an independent company to maintain share registers, in
practice, such companies have not always followed this law. Because of this lack
of independence of registrars,  management of a Russian  company may be able  to
exert considerable influence over who can purchase and sell the company's shares
by  illegally instructing the registrar to  refuse to record transactions on the
share register.  Furthermore, these  practices may  prevent the  Portfolio  from
investing  in the securities of certain Russian companies deemed suitable by the
Adviser and  could cause  a  delay in  the sale  of  Russian securities  by  the
Portfolio  if the  company deems  a purchaser  unsuitable, which  may expose the
Portfolio to potential loss on its investment.
 
    In light  of  the risks  described  above, the  Board  of Directors  of  the
Portfolio has approved certain procedures concerning the Portfolio's investments
in  Russian  securities.  Among  these  procedures  is  a  requirement  that the
Portfolio will  not invest  in the  securities of  Russian issuers  unless  that
issuer's   registrar  has   entered  into   a  contract   with  the  Portfolio's
sub-custodian containing certain  protective conditions  including, among  other
things,  the  sub-custodian's right  to conduct  regular share  confirmations on
behalf of  the  Portfolio. This  requirement  will  likely have  the  effect  of
precluding  investments in  certain Russian  companies that  the Portfolio would
otherwise make.
 
    SHORT SALES.  The  Emerging Markets Debt and  Latin American Portfolios  may
from  time to time sell securities short without limitation, but consistent with
applicable legal  requirements. A  short  sale is  a  transaction in  which  the
Portfolio  sells securities it owns or has the right to acquire at no added cost
(i.e., "against the box") or does not own (but has borrowed) in anticipation  of
a  decline in the market  price of the securities.  To deliver the securities to
the buyer, the Portfolio arranges through a broker to borrow the securities and,
in so doing, the Portfolio becomes obligated to replace the securities  borrowed
at  their market price  at the time  of replacement. When  the Portfolio makes a
short sale, the proceeds it receives from the  sale will be held on behalf of  a
broker  until the Portfolio replaces the  borrowed securities. The Portfolio may
have to pay a  premium to borrow  the securities and must  pay any dividends  or
interest payable on the securities until they are replaced.
 
    The  Portfolio's obligation to replace the securities borrowed in connection
with a short sale will be secured  by collateral deposited with the broker  that
consists  of cash  or other liquid  securities. In addition,  the Portfolio will
place in a  segregated account with  its Custodian  an amount of  cash or  other
liquid  securities equal to the difference, if any, between (1) the market value
of the securities  sold at the  time they were  sold short and  (2) any cash  or
other  liquid securities deposited  as collateral with  the broker in connection
with the short sale. Short
 
                                       24
<PAGE>
sales by  the  Portfolio  involve  certain  risks  and  special  considerations.
Possible  losses from short sales differ from losses that could be incurred from
a purchase of  a security,  because losses from  short sales  may be  unlimited,
whereas losses from purchases can equal only the total amount invested.
 
    STRUCTURED  SECURITIES.   The Emerging Markets  Debt Portfolio  may invest a
portion of its assets in entities organized and operated solely for the  purpose
of  restructuring the investment characteristics  of sovereign debt obligations.
This type of restructuring involves the deposit with, or purchase by, an entity,
such as a  corporation or trust,  of specified instruments  (such as  commercial
bank  loans or  Brady Bonds)  and the  issuance by  that entity  of one  or more
classes of  securities  ("Structured  Securities") backed  by,  or  representing
interests  in,  the  underlying instruments.  The  cash flow  on  the underlying
instruments may be apportioned among  the newly issued Structured Securities  to
create  securities with  different investment  characteristics, such  as varying
maturities, payment priorities and interest  rate provisions, and the extent  of
the  payments made  with respect  to Structured  Securities is  dependent on the
extent of  the cash  flow on  the underlying  instruments. Because  the type  of
Structured  Securities  in  which  the  Portfolio  anticipates  it  will  invest
typically involve no  credit enhancement,  their credit risk  generally will  be
equivalent  to that of the underlying instruments. The Portfolio is permitted to
invest in  a class  of  Structured Securities  that  is either  subordinated  or
unsubordinated to the right of payment of another class. Subordinated Structured
Securities   typically  have  higher  yields  and  present  greater  risks  than
unsubordinated Structured Securities. Certain  issuers of Structured  Securities
may  be deemed to be "investment companies" as defined in the 1940 Act and, as a
result, the Portfolio's investment  in Structured Securities  may be limited  by
the  1940 Act.  Structured Securities  are typically  sold in  private placement
transactions, and there  currently is  no active trading  market for  Structured
Securities.
 
    TEMPORARY  INVESTMENTS.  For temporary  defensive purposes, when the Adviser
determines that market conditions warrant, each Portfolio may invest up to  100%
of  its assets in dollar and non-dollar denominated money market instruments and
short- and medium-term debt securities that  the Adviser believes to be of  high
quality,  or hold cash.  The short- and  medium-term debt securities  in which a
Portfolio may invest consist of (a)  obligations of the U.S. or foreign  country
governments,  their respective agencies or  instrumentalities; (b) bank deposits
and bank  obligations  (including certificates  of  deposit, time  deposits  and
bankers'  acceptances)  of  U.S. or  foreign  country banks  denominated  in any
currency; (c) floating rate securities and other instruments denominated in  any
currency  issued by international development  agencies; (d) finance company and
corporate commercial paper  and other short-term  corporate debt obligations  of
U.S.  and foreign  country corporations  meeting the  Portfolio's credit quality
standards; and  (e) repurchase  agreements with  banks and  broker-dealers  with
respect to such securities.
 
    WHEN-ISSUED  AND DELAYED DELIVERY  SECURITIES.  Each  Portfolio may purchase
securities on a  when-issued or  delayed delivery basis.  In such  transactions,
instruments  are bought with payment and delivery  taking place in the future in
order to secure what is considered to  be an advantageous yield or price at  the
time  of  the transaction.  Each Portfolio  will maintain  with the  Custodian a
separate account with a segregated portfolio of cash or other liquid  securities
in an amount at least equal to these commitments. The payment obligation and the
interest  rates that will be  received are each fixed  at the time the Portfolio
enters into  the commitment  and  no interest  accrues  to the  Portfolio  until
settlement. Thus, it is possible that the market value at the time of settlement
could  be higher or lower  than the purchase price  if, among other factors, the
general level of interest
 
                                       25
<PAGE>
rates has changed. It is  a current policy of each  Portfolio not to enter  into
when-issued   commitments  or  delayed  delivery  securities  exceeding  in  the
aggregate 15%  of  the  market  value  of  the  Portfolio's  total  assets  less
liabilities, other than the obligations created by these commitments.
 
DERIVATIVE INSTRUMENTS
 
    The Portfolios are permitted to invest in various derivative instruments for
both  hedging and non-hedging purposes.  Derivative instruments include options,
futures and options  on futures,  structured investments  and structured  notes,
caps,  floors, collars  and swaps.  Additionally, the  Portfolios may  invest in
other derivative instruments that are developed over time if their use would  be
consistent  with the objectives of the Portfolios. Each Portfolio will limit its
use of derivative instruments  to 33 1/3%  of its total  assets measured by  the
aggregate notional amount of outstanding derivative instruments. The Portfolios'
investments  in  forward foreign  currency  contracts and  derivatives  used for
hedging purposes are not subject to the limit described above.
 
    The Portfolios may use  derivative instruments under  a number of  different
circumstances  to further  their investment  objectives. The  Portfolios may use
derivatives when doing so  provides more liquidity than  the direct purchase  of
the  securities  underlying  such  derivatives.  For  example,  a  Portfolio may
purchase derivatives to quickly gain exposure to a market in response to changes
in the Portfolio's investment  strategy, upon the inflow  of investable cash  or
when  the derivative provides  greater liquidity than  the underlying securities
market. A Portfolio may also use derivatives when it is restricted from directly
owning the underlying securities due to foreign investment restrictions or other
reasons or  when  doing  so  provides a  price  advantage  over  purchasing  the
underlying securities directly, either because of a pricing differential between
the  derivatives and  securities markets or  because of  lower transaction costs
associated with the derivatives transaction. Derivatives  may also be used by  a
Portfolio  for hedging  purposes and in  other circumstances  when a Portfolio's
portfolio managers  believe  it  advantageous  to  do  so  consistent  with  the
Portfolio's   investment  objective.  The  Portfolios  will  not,  however,  use
derivatives in a manner that creates leverage, except to the extent that the use
of leverage  is  expressly  permitted by  a  particular  Portfolio's  investment
policies, and then only in a manner consistent with such policies.
 
    Some  of the derivative  instruments in which the  Portfolios may invest and
the risks related thereto are described in more detail below.
 
CAPS, FLOORS AND COLLARS
 
    The Portfolios may invest in caps, floors and collars, which are instruments
analogous to options. In particular, a cap is the right to receive the excess of
a reference rate over a given rate and is analogous to a put option. A floor  is
the  right to receive  the excess of a  given rate over a  reference rate and is
analogous to a call option. Finally, a  collar is an instrument that combines  a
cap  and a floor. That is, the buyer of  a collar buys a cap and writes a floor,
and the writer of a collar writes a  cap and buys a floor. The risks  associated
with  caps, floors and collars are similar  to those associated with options. In
addition, caps,  floors  and collars  are  subject to  risk  of default  by  the
counterparty because they are privately negotiated instruments.
 
FUTURES CONTRACTS AND OPTIONS ON FUTURES CONTRACTS
 
    The  Portfolios  may  purchase and  sell  futures contracts  and  options on
futures contracts,  including  but  not limited  to  securities  index  futures,
foreign  currency exchange  futures, interest  rate futures  and other financial
futures. Futures contracts  provide for the  sale by one  party and purchase  by
another party of a specified amount
 
                                       26
<PAGE>
of  a specific security, instrument or basket thereof, at a specific future date
and at a specified price.  An option on a futures  contract is a legal  contract
that  gives the holder  the right to buy  or sell a  specified amount of futures
contracts at a fixed or determinable price upon the exercise of the option.
 
    The Portfolios may  sell securities index  futures contracts and/or  options
thereon  in anticipation of or during a  market decline to attempt to offset the
decrease in market value of investments in its portfolio, or purchase securities
index futures in order to gain market exposure. Subject to applicable laws,  the
Portfolios may engage in transactions in securities index futures contracts (and
options  thereon)  which  are  traded  on  a  recognized  securities  or futures
exchange, or  may purchase  or  sell such  instruments in  the  over-the-counter
market. There currently are limited securities index futures and options on such
futures  in many countries,  particularly emerging countries.  The nature of the
strategies adopted by the Adviser, and the extent to which those strategies  are
used, may depend on the development of such markets.
 
    The  Portfolios  may  engage  in  transactions  involving  foreign  currency
exchange futures contracts. Such contracts involve an obligation to purchase  or
sell  a specific currency at  a specified future date  and at a specified price.
The Portfolios  may  engage  in  such transactions  to  hedge  their  respective
holdings  and commitments against changes in  the level of future currency rates
or to adjust their exposure to a particular currency.
 
    The  Portfolios  may  engage  in  transactions  in  interest  rate   futures
transactions.  Interest rate futures contracts involve an obligation to purchase
or sell a specific  debt security, instrument or  basket thereof at a  specified
future  date at  a specified price.  The value  of the contract  rises and falls
inversely with changes  in interest  rates. The  Portfolios may  engage in  such
transactions  to hedge their holdings of debt instruments against future changes
in interest rates.
 
    Financial futures are futures  contracts relating to financial  instruments,
such  as  U.S. Government  securities, foreign  currencies, and  certificates of
deposit. Such contracts  involve an obligation  to purchase or  sell a  specific
security, instrument or basket thereof at a specified future date at a specified
price.  Like interest  rate futures  contracts, the  value of  financial futures
contracts rises  and  falls  inversely  with  changes  in  interest  rates.  The
Portfolios may engage in financial futures contracts for hedging and non-hedging
purposes.
 
    Under  rules  adopted  by  the Commodity  Futures  Trading  Commission, each
Portfolio may enter into futures contracts and options thereon for both  hedging
and  non-hedging purposes,  provided that not  more than 5%  of such Portfolio's
total assets at the time of entering the transaction are required as margin  and
option   premiums  to  secure  obligations  under  such  contracts  relating  to
non-hedging activities.
 
    Gains and losses  on futures  contracts and  options thereon  depend on  the
Adviser's  ability  to predict  correctly  the direction  of  securities prices,
interest rates and other economic factors.  Other risks associated with the  use
of  futures  and options  are (i)  imperfect correlation  between the  change in
market value of investments held  by a Portfolio and  the prices of futures  and
options  relating to  investments purchased or  sold by the  Portfolio, and (ii)
possible lack  of a  liquid secondary  market  for a  futures contract  and  the
resulting  inability to close a futures position. The risk that a Portfolio will
be unable to close out a futures position or options contract will be  minimized
by  only entering into futures contracts or options transactions for which there
appears to be a liquid exchange or secondary market. The risk of loss in trading
on futures contracts in some strategies can be substantial, due both to the  low
margin  deposits required and the extremely  high degree of leverage involved in
futures pricing.
 
                                       27
<PAGE>
OPTIONS TRANSACTIONS
 
    The Portfolios  may  seek to  increase  their  returns or  may  hedge  their
portfolio  investments through options transactions  with respect to securities,
instruments, indices or baskets thereof in which such Portfolios may invest,  as
well  as  with respect  to foreign  currency.  Purchasing a  put option  gives a
Portfolio the  right  to  sell  a specified  security,  currency  or  basket  of
securities  or  currencies at  the exercise  price until  the expiration  of the
option. Purchasing  a call  option gives  a Portfolio  the right  to purchase  a
specified  security,  currency  or basket  of  securities or  currencies  at the
exercise price until the expiration of the option.
 
    Each Portfolio  also  may  write  (i.e.,  sell)  put  and  call  options  on
investments  held in its portfolio, as well as with respect to foreign currency.
A Portfolio that has written an  option receives a premium, which increases  the
Portfolio's  return on  the underlying security  or instrument in  the event the
option expires unexercised or is closed out  at a profit. However, by writing  a
call  option, a Portfolio will limit its  opportunity to profit from an increase
in the market value of the underlying security or instrument above the  exercise
price  of the option for as long as  the Portfolio's obligation as writer of the
option continues. The Portfolios  may only write options  that are "covered."  A
covered  call option  means that so  long as  the Portfolio is  obligated as the
writer of the option, it will  earmark or segregate sufficient liquid assets  to
cover  its obligations under  the option or  own (i) the  underlying security or
instrument subject to the option, (ii) securities or instruments convertible  or
exchangeable  without  the payment  of any  consideration  into the  security or
instrument subject to the option, or (iii) a call option on the same  underlying
security  with a strike price  no higher than the  price at which the underlying
instrument was sold pursuant to a short option position.
 
    By writing (or selling)  a put option, a  Portfolio incurs an obligation  to
buy  the security or instrument underlying the  option from the purchaser of the
put at the option's exercise price at any time during the option period, at  the
purchaser's  election.  The  Portfolios  may  also  write  options  that  may be
exercised by the purchaser only on a specific date. A Portfolio that has written
a put option  will earmark or  segregate sufficient liquid  assets to cover  its
obligations  under the option  or will own  a put option  on the same underlying
security with an equal or higher strike price.
 
    The Portfolios may  engage in transactions  in options which  are traded  on
recognized  exchanges or  over-the-counter. There currently  are limited options
markets in  many  countries,  particularly  emerging  countries  such  as  Latin
American  countries, and the nature of the strategies adopted by the Adviser and
the extent to which those strategies are used will depend on the development  of
such  options markets. The primary risks associated  with the use of options are
(i) imperfect  correlation between  the change  in market  value of  investments
held,  purchased or sold  by a Portfolio  and the prices  of options relating to
such investments, and  (ii) possible lack  of a liquid  secondary market for  an
option.
 
STRUCTURED NOTES
 
    Structured  Notes are derivatives on which the amount of principal repayment
and/or interest payments  is based  upon the movement  of one  or more  factors.
These factors include, but are not limited to, currency exchange rates, interest
rates  (such as the prime lending rate and  LIBOR) and stock indices such as the
S&P 500 Index. In some cases, the  impact of the movements of these factors  may
increase or decrease through the use of multipliers or deflators. The Portfolios
may  use structured notes to tailor their  investments to the specific risks and
returns the Adviser wishes  to accept while avoiding  or reducing certain  other
risks.
 
                                       28
<PAGE>
SWAPS -- SWAP CONTRACTS
 
    Swaps  and Swap Contracts are derivatives in the form of a contract or other
similar instrument in which two parties agree to exchange the returns  generated
by  a security, instrument, basket or index thereof for the returns generated by
another security, instrument, basket thereof  or index. The payment streams  are
calculated  by  reference to  a specific  security, index  or instrument  and an
agreed upon notional amount.  The relevant indices include  but are not  limited
to,  currencies, fixed interest rates, prices  and total return on interest rate
indices, fixed income indices, stock indices  and commodity indices (as well  as
amounts  derived from  arithmetic operations on  these indices).  For example, a
Portfolio may agree to swap the return generated by a fixed income index for the
return generated by a second fixed income index. The currency swaps in which the
Portfolios may enter will generally involve an agreement to pay interest streams
in one currency based  on a specified index  in exchange for receiving  interest
streams  denominated in  another currency.  Such swaps  may involve  initial and
final exchanges that correspond to the agreed upon notional amount.
 
    A Portfolio will  usually enter into  swaps on  a net basis,  i.e., the  two
return  streams are netted out in a cash settlement on the payment date or dates
specified in the instrument, with a  Portfolio receiving or paying, as the  case
may  be, only the net amount of the two returns. A Portfolio's obligations under
a swap agreement will be accrued daily (offset against any amounts owing to  the
Portfolio)  and any accrued, but unpaid, net amounts owed to a swap counterparty
will be covered by the maintenance of a segregated account consisting of cash or
liquid securities. A Portfolio will not enter into any swap agreement unless the
counterparty meets the rating requirements  set forth in guidelines  established
by the Fund's Board of Directors.
 
    Interest  rate and total rate of return swaps do not involve the delivery of
securities, other underlying assets, or principal. Accordingly, the risk of loss
with respect to interest rate and total  rate of return swaps is limited to  the
net  amount of payments that a Portfolio  is contractually obligated to make. If
the other party to  an interest rate  or total rate of  return swap defaults,  a
Portfolio's risk of loss consists of the net amount of payments that a Portfolio
is  contractually entitled to  receive. In contrast,  currency swaps may involve
the delivery  of  the entire  principal  value  of one  designated  currency  in
exchange  for  the other  designated currency.  Therefore, the  entire principal
value of a currency swap may be subject to the risk that the other party to  the
swap will default on its contractual delivery obligations. If there is a default
by  the counterparty, a Portfolio may  have contractual remedies pursuant to the
agreements related to the transaction. The swaps market has grown  substantially
in recent years with a large number of banks and investment banking firms acting
both as principals and as agents utilizing standardized swap documentation. As a
result,  the swaps market has become relatively liquid. Swaps that include caps,
floors  and  collars  are  more   recent  innovations  for  which   standardized
documentation  has not yet been fully  developed and, accordingly, they are less
liquid than "traditional" swaps.
 
    The use of swaps is a highly specialized activity which involves  investment
techniques  and risks  different from  those associated  with ordinary portfolio
securities transactions. If the Adviser is incorrect in its forecasts of  market
values,  interest rates, and currency exchange rates, the investment performance
of the  Portfolios would  be less  favorable than  it would  have been  if  this
investment technique were not used.
 
                                       29
<PAGE>
                             INVESTMENT LIMITATIONS
 
    Each  Portfolio is  a non-diversified  portfolio under  the 1940  Act, which
means that the Portfolio is not limited by the 1940 Act in the proportion of its
assets that may be invested  in the obligations of  a single issuer. Thus,  each
Portfolio  may invest a greater proportion of its total assets in the securities
of a smaller number of issuers and, as a result, will be subject to greater risk
with respect to its portfolio  securities. Nevertheless, each Portfolio  intends
to  comply with  the more  limited diversification  requirements imposed  by the
Internal Revenue Code of 1986, as  amended (the "Code"), for qualification as  a
regulated investment company.
 
    Each  Portfolio  operates  under certain  investment  restrictions  that are
deemed fundamental limitations and may be changed only with the approval of  the
holders  of a majority  of the Portfolio's outstanding  shares and under certain
non-fundamental investment limitations that  may be changed without  shareholder
approval.   For  additional  information   on  fundamental  and  non-fundamental
investment  limitations,  see  "Investment  Limitations"  in  the  Statement  of
Additional Information.
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator  of the Fund  and each Portfolio.  The Adviser provides investment
advice and portfolio  management services,  pursuant to  an Investment  Advisory
Agreement  and, subject  to the  supervision of  the Fund's  Board of Directors,
makes each of the Portfolio's day-to-day investment decisions, arranges for  the
execution   of  portfolio  transactions  and   generally  manages  each  of  the
Portfolio's investments. The Adviser is entitled to receive from each  Portfolio
an  annual management fee, payable quarterly, equal to the percentage of average
daily net assets set forth in the  table below. However, the Adviser has  agreed
to  a reduction  in the fees  payable to it  and to reimburse  the Portfolio, if
necessary, if  such fees  would cause  the total  annual operating  expenses  of
either  Portfolio  to exceed  the respective  percentages  of average  daily net
assets set forth in the table below.
 
<TABLE>
<CAPTION>
                                                  MAXIMUM TOTAL ANNUAL
                                                        OPERATING
                                                   EXPENSES AFTER FEE
                                                         WAIVERS
                                  MANAGEMENT    -------------------------
          PORTFOLIO                   FEE        CLASS A         CLASS B
- ------------------------------    -----------   ---------       ---------
<S>                               <C>           <C>             <C>
Emerging Markets Portfolio             1.25%       1.75%           2.00%
Emerging Markets Debt
 Portfolio                             1.00%       1.75%           2.00%
Latin American Portfolio               1.10%       1.70%           1.95%
</TABLE>
 
    The Adviser, with  principal offices  at 1221  Avenue of  the Americas,  New
York,  New York  10020, conducts a  worldwide portfolio  management business and
provides a broad  range of  portfolio management  services to  customers in  the
United  States and  abroad. The Adviser  and Morgan Stanley  are subsidiaries of
Morgan Stanley, Dean  Witter, Discover  & Co. At  August 31,  1997, the  Adviser
(exclusive of Miller Anderson & Sherrerd, LLP, Van Kampen American Capital, Inc.
and  Dean  Witter  InterCapital  Inc.)  managed  assets  of  approximately $80.9
billion.  See  "Management  of  the   Fund"  in  the  Statement  of   Additional
Information.
 
    PORTFOLIO  MANAGERS.    The  following  individuals  have  primary portfolio
management responsibility for the Portfolios noted below:
 
    EMERGING MARKETS PORTFOLIO -- MADHAV DHAR AND ROBERT L. MEYER.  Madhav  Dhar
joined  the Adviser  in 1984. He  is a Managing  Director of the  Adviser and of
Morgan Stanley. He is a member of the Adviser's
 
                                       30
<PAGE>
executive committee,  head of  the Adviser's  emerging markets  group and  chief
investment officer of the Adviser's global emerging market equity portfolios. He
holds  a B.S. (honors) from St. Stephen's College, Delhi University India and an
M.B.A. from Carnegie-Mellon University. Mr. Dhar has been primarily  responsible
for  managing the  Portfolio's assets since  it commenced  operations. Robert L.
Meyer joined the Adviser in 1989. He  is a Managing Director of the Adviser  and
of  Morgan Stanley  and co-manager of  the Adviser's emerging  markets group and
head of  the  Adviser's  Latin American  team.  He  was born  in  Argentina  and
graduated  from Yale University with a  B.A. in Economics and Political Science.
He received a J.D. from Harvard Law School. In addition, he is also a  Chartered
Financial  Analyst.  Mr.  Meyer  has  worked  with  Mr.  Dhar  in  managing  the
Portfolio's assets since its inception.
 
    EMERGING MARKETS  DEBT PORTFOLIO  --  PAUL GHAFFARI.    Paul Ghaffari  is  a
Managing  Director of Morgan  Stanley. He joined  the Adviser in  June 1993 as a
Vice President and  Portfolio Manager  for the Morgan  Stanley Emerging  Markets
Debt  Fund (a closed-end investment company).  Prior to joining the Adviser, Mr.
Ghaffari was  a Vice  President in  the Fixed  Income Division  of the  Emerging
Markets  Sales and Trading Department  at Morgan Stanley. From  1983 to 1992, he
worked in LDC Sales  and Trading Department  and the Mortgage-Backed  Securities
Department  at J.P. Morgan &  Co. Inc. and worked  in the Treasury Department at
the Morgan Guaranty Trust  Co. He holds a  B.A. in International Relations  from
Pamona  College and an  M.S. in Foreign Service  from Georgetown University. Mr.
Ghaffari has  had primary  responsibility for  managing the  Portfolio's  assets
since inception.
 
    LATIN AMERICAN PORTFOLIO -- ROBERT L. MEYER AND ANDY SKOV.  Robert Meyer and
Andy  Skov  share primary  responsibility for  managing the  Portfolio's assets.
Information about Mr.  Meyer is  included under the  Emerging Markets  Portfolio
above.  Andy Skov joined the Adviser in  1994 as a Portfolio Manager. Currently,
he is a Vice President of the  Adviser. Prior to joining the Adviser, he  worked
in  the Latin America group at Bankers  Trust in corporate finance, research and
sales; two  of  those  years  he  spent in  Argentina.  He  graduated  from  the
University  of California at Berkeley with a  B.A. (Phi Beta Kappa) in Political
Science and Economics Development.
 
    ADMINISTRATOR.  The  Adviser also  provides administrative  services to  the
Fund  pursuant to an  Administration Agreement. The  services provided under the
Administration Agreement are subject to the supervision of the Officers and  the
Board  of Directors of the Fund and include day-to-day administration of matters
related to the  corporate existence  of the  Fund, maintenance  of its  records,
preparation  of  reports,  supervision  of  the  Fund's  arrangements  with  its
custodian  and  assistance  in  the  preparation  of  the  Fund's   registration
statements  under federal laws. The  Administration Agreement also provides that
the Administrator,  through its  agents, will  provide dividend  disbursing  and
transfer  agent services to the Fund.  For its services under the Administration
Agreement, the Fund  pays the Adviser  a monthly  fee which on  an annual  basis
equals 0.15% of the average daily net assets of each Portfolio.
 
    Under  an  agreement  between  the  Adviser  and  The  Chase  Manhattan Bank
("Chase"), Chase provides  certain administrative services  to the Fund  through
its  corporate  affiliate, Chase  Global Funds  Services Company  ("CGFSC"). The
Adviser supervises and monitors administrative services provided by CGFSC. Their
services are also subject to  the supervision of the  Board of Directors of  the
Fund.  CGFSC's  business address  is  73 Tremont  Street,  Boston, Massachusetts
02108-3913.
 
                                       31
<PAGE>
    LOCAL ADMINISTRATORS FOR THE EMERGING MARKETS PORTFOLIO.  The Portfolio has,
as required  by local  law, entered  into administration  agreements with  local
administrators  in Brazil and  Colombia. A local  administrator provides certain
services for the Portfolio with respect  to the Portfolio's investments in  that
country,   including  services  relating  to   foreign  exchange,  local  taxes,
remittance of income  and capital  gains, and repatriation  of investments.  The
Portfolio's   local  administrator   in  Brazil,   Unibanco-Uniao,  a  Brazilian
corporation, is  paid by  an annual  fee of  0.125% of  the Portfolio's  average
weekly  net assets  invested in Brazil.  The Portfolio's  local administrator in
Colombia, CitiTrust S.A.,  a Colombian  trust company, is  paid by  the Fund  an
annual fee of $1,000 plus 0.20% per transaction in Colombia.
 
    LOCAL  ADMINISTRATORS FOR THE LATIN AMERICAN  PORTFOLIO.  The Portfolio has,
as required  by local  law, entered  into administration  agreements with  local
administrators  in Brazil, Chile,  and Colombia. A  local administrator provides
certain services for the Portfolio  with respect to the Portfolio's  investments
in  that country, including services relating  to foreign exchange, local taxes,
remittance of income  and capital  gains, and repatriation  of investments.  The
Portfolio's   local  administrator   in  Brazil,   Unibanco-Uniao,  a  Brazilian
corporation, is paid  by the Fund  an annual  fee of 0.125%  of the  Portfolio's
average   weekly  net   assets  invested   in  Brazil.   The  Portfolio's  local
administrator in  Chile, Bice  Chileconsult Agente  de Valores  S.A., a  Chilean
corporation,  is paid  by the Fund  an annual  fee of 0.125%  of the Portfolio's
average weekly net assets invested in Chile. The Portfolio's local administrator
in Colombia, CitiTrust S.A., a Colombian trust  company, is paid by the Fund  an
annual fee of $1,000 plus 0.20% per transaction in Colombia.
 
    DIRECTORS  AND OFFICERS.  Pursuant to  the Fund's Articles of Incorporation,
the Board of Directors  decides upon matters of  general policy and reviews  the
actions  of  the Fund's  Adviser, Administrator,  Distributor and  other service
providers. The officers  of the Fund  conduct and supervise  its daily  business
operations.
 
    DISTRIBUTOR.   Morgan  Stanley serves  as the  exclusive Distributor  of the
shares of  the Fund.  Under its  Distribution Agreement  with the  Fund,  Morgan
Stanley  sells  shares of  each  Portfolio upon  the  terms and  at  the current
offering price described in this Prospectus. Morgan Stanley is not obligated  to
sell any certain number of shares of any Portfolio.
 
    The  Portfolios currently offer  only the classes of  shares offered by this
Prospectus. The Portfolio may in the future offer one or more classes of  shares
with  features, distribution expenses or other  expenses that are different from
those of the classes currently offered.
 
    The Fund has  adopted a Plan  of Distribution  with respect to  the Class  B
shares  for each Portfolio  pursuant to Rule  12b-1 under the  1940 Act (each, a
"Plan"). Under  each Plan,  the  Distributor is  entitled  to receive  from  the
Portfolios  a distribution  fee, which is  accrued daily and  paid quarterly, of
0.25% of the Class B  shares' average daily net  assets on an annualized  basis.
The  Distributor  expects  to  reallocate  most of  its  fee  to  its investment
representatives. The Distributor may, in its discretion, voluntarily waive  from
time  to  time all  or  any portion  of  its distribution  fee  and each  of the
Distributor and the Adviser is free to  make additional payments out of its  own
assets  to promote the  sale of Fund shares,  including payments that compensate
financial institutions for distribution services or shareholder services.
 
    Each Plan is designed to compensate the Distributor for its services, not to
reimburse the Distributor for its expenses,  and the Distributor may retain  any
portion  of the fee that it does not expend in fulfillment of its obligations to
the Fund.
 
                                       32
<PAGE>
    PAYMENTS TO  FINANCIAL INSTITUTIONS.    The Adviser  or its  affiliates  may
compensate  certain financial institutions for the continued investment of their
customers' assets in the  Emerging Markets Portfolio pursuant  to the advice  of
such financial institutions. These payments will be made directly by the Adviser
or its affiliates from their assets, and will not be made from the assets of the
Fund  or  by  the  assessment  of  a  sales  charge  on  shares.  Such financial
institutions may also perform certain shareholder or recordkeeping services that
would otherwise be performed  by CGFSC. The  Adviser may elect  to enter into  a
contract to pay the financial institutions for such services.
 
    EXPENSES.   Each Portfolio is responsible  for payment of certain other fees
and expenses  (including organizational  costs, legal  fees, accountant's  fees,
custodial  fees, and printing and mailing costs) specified in the Administration
and Distribution Agreements.
 
                               PURCHASE OF SHARES
 
    Class A and Class  B shares of  each Portfolio may be  purchased at the  net
asset value per share next determined after receipt of the purchase order by the
Portfolio. See "Valuation of Shares."
 
MINIMUM INVESTMENT AND ACCOUNT SIZES; CONVERSION FROM CLASS A TO CLASS B SHARES
 
    For  a  Portfolio  account  opened  on or  after  January  2,  1996  (a "New
Account"), the minimum initial investment and minimum account size are  $500,000
for  Class A shares and  $100,000 for Class B  shares of each Portfolio. Certain
advisory or asset allocation accounts, such as Total Funds Management  accounts,
managed  by Morgan  Stanley or its  affiliates, including  the Adviser ("Managed
Accounts") may purchase  Class A  shares without  being subject  to any  minimum
initial investment or minimum account size requirements for a Portfolio account.
Employees  of the  Adviser and  certain of its  affiliates may  purchase Class A
Shares subject  to conditions,  including a  lower minimum  initial  investment,
established by Officers of the Fund.
 
    If  the  value of  a  New Account,  containing  Class A  shares  falls below
$500,000  (but   remains  at   or  above   $100,000)  because   of   shareholder
redemption(s),  the Fund will  notify the shareholder, and  if the account value
remains below  $500,000 (but  remains at  or above  $100,000) for  a  continuous
60-day period, the Class A shares in such account will convert to Class B shares
and will be subject to the distribution fee and other features applicable to the
Class  B shares. The Fund,  however, will not convert Class  A shares to Class B
shares based solely upon changes in the  market that reduce the net asset  value
of  shares. Under current tax  law, conversions between share  classes are not a
taxable event to the shareholder.
 
    Shares in a Portfolio account opened  prior to January 2, 1996 (a  "Pre-1996
Account")  were  designated Class  A  shares on  January  2, 1996.  Shares  in a
Pre-1996 Account  with  a  value  of  $100,000 or  more  on  March  1,  1996  (a
"Grandfathered  Class A Account") remained Class  A shares regardless of account
size thereafter. Except for  shares in a Managed  Account, shares in a  Pre-1996
Account  with a value of  less than $100,000 on  March 1, 1996 (a "Grandfathered
Class B Account") converted  to Class B shares  on March 1, 1996.  Grandfathered
Class A Accounts and Managed Accounts are not subject to conversion from Class A
shares to Class B shares.
 
    Investors  may also invest in the Fund  by purchasing shares through a trust
department, broker, dealer, agent, financial planner, financial services firm or
investment adviser.  An  investor  may  be  charged  an  additional  service  or
transaction fee by that institution.
 
                                       33
<PAGE>
    The minimum investment levels may be waived at the discretion of the Adviser
for  (i) certain employees and customers of Morgan Stanley or its affiliates and
certain  trust  departments,  brokers,   dealers,  agents,  financial   planers,
financial  services  firms  or investment  advisers  that have  entered  into an
agreement with  Morgan  Stanley  or  its affiliates;  and  (ii)  retirement  and
deferred  compensation plans and trusts, used to fund such plans, including, but
not limited to, those defined in Section  401(a), 403(b) or 457 of the Code  and
"rabbi  trusts".  The  Fund  reserves  the  right  to  modify  or  terminate the
conversion features  of the  shares as  stated above  at any  time upon  60-days
notice to shareholders.
 
    The  Adviser reserves the right in its sole discretion to determine which of
such advisory  or  asset allocation  accounts  shall be  Managed  Accounts.  For
information  regarding  Managed  Accounts, please  contact  your  Morgan Stanley
account representative or the Fund at the telephone number provided on the cover
of this Prospectus.
 
MINIMUM ACCOUNT SIZES AND INVOLUNTARY REDEMPTION OF SHARES
 
    If the value of  a New Account falls  below $100,000 because of  shareholder
redemption(s),  the Fund will  notify the shareholder, and  if the account value
remains below  $100,000 for  a  continuous 60-day  period,  the shares  in  such
account  are subject to redemption  by the Fund and,  if redeemed, the net asset
value of  such  shares will  be  promptly paid  to  the shareholder.  The  Fund,
however,  will not redeem  shares based solely  upon changes in  the market that
reduce the net asset value of shares.
 
    Grandfathered Class A Accounts, Grandfathered  Class B Accounts and  Managed
Accounts  are not subject to involuntary redemption. The Fund reserves the right
to modify or  terminate the  involuntary redemption  features of  the shares  as
stated above at any time upon 60-days notice to shareholders.
 
CONVERSION FROM CLASS B TO CLASS A SHARES
 
    If the value of Class B shares in a Portfolio account increases, whether due
to  shareholder share  purchases or  market activity,  to $500,000  or more, the
Class B shares  will convert  to Class  A shares.  Under current  tax law,  such
conversion  is not a taxable event to  the shareholder. Class A shares converted
from Class B shares  are subject to the  same minimum account size  requirements
that  are applicable to New Accounts containing Class A shares, as stated above.
The Fund reserves the  right to modify or  terminate this conversion feature  at
any time upon 60-days notice to shareholders.
 
INITIAL PURCHASES DIRECTLY FROM THE FUND
 
    The  Fund's determination of an investor's eligibility to purchase shares of
a given class will take precedence over the investor's selection of a class.
 
1) BY CHECK.   An account may  be opened  by completing and  signing an  Account
   Registration  Form, and mailing  it, together with  a check ($500,000 minimum
   for Class A shares of each Portfolio and $100,000 minimum for Class B  shares
   of  each Portfolio, with certain exceptions  for Morgan Stanley employees and
   select customers)  payable to  "Morgan Stanley  Institutional Fund,  Inc.  --
   [portfolio name]", to:
 
      Morgan Stanley Institutional Fund, Inc.
      P.O. Box 2798
      Boston, Massachusetts 02208-2798
 
                                       34
<PAGE>
     Payment will  be accepted only  in U.S. dollars,  unless prior approval for
  payment by other currencies is given by the Fund. The classes of shares of the
  Portfolio(s) to be purchased should be designated on the Account  Registration
  Form.  For purchases  by check, the  Fund is ordinarily  credited with Federal
  Funds within  one business  day. Thus,  your purchase  of shares  by check  is
  ordinarily  credited to your account at the  net asset value per share of each
  of the Portfolios determined on the next business day after receipt.
 
2) BY FEDERAL  FUNDS WIRE.   Purchases  may be  made by  having your  bank  wire
   Federal  Funds to the Fund's bank account.  In order to ensure prompt receipt
   of your Federal Funds Wire, it is important that you follow these steps:
 
A.  Telephone  the Fund  (toll free: 1-800-548-7786)  and provide  us with  your
    name,  address,  telephone  number, Social  Security  or  Tax Identification
    Number, the  portfolio(s) selected,  the class  selected, the  amount  being
    wired,  and by  which bank.  We will  then provide  you with  a Fund account
    number. (Investors with existing accounts should also notify the Fund  prior
    to wiring funds.)
 
B.    Instruct  your  bank to  wire  the  specified amount  to  the  Fund's Wire
    Concentration Bank Account (be  sure to have your  bank include the name  of
    the  portfolio(s)  selected,  the  class  selected  and  the  account number
    assigned to you) as follows:
 
    The Chase Manhattan Bank
    One Manhattan Plaza
    New York, NY 10081-1000
    ABA#021000021
    DDA# 910-2-733293
    Attn: Morgan Stanley Institutional Fund, Inc.
    Ref: (Portfolio name, your account number, your account name)
 
    Please call the Fund at 1-800-548-7786 prior to wiring funds.
 
C.  Complete and sign the Account  Registration Form and mail it to the  address
    shown thereon.
 
    The  purchase price of the  Class A and Class B  shares of the Portfolios is
    the net  asset  value next  determined  after  the order  is  received.  See
    "Valuation  of Shares." An order received prior  to the regular close of the
    New York Stock Exchange ("NYSE"), which is currently 4:00 p.m. Eastern Time,
    will be executed  at the price  computed on  the date of  receipt; an  order
    received  after the regular close of the  NYSE will be executed at the price
    computed on the  next day the  NYSE is open  as long as  the Transfer  Agent
    receives  payment by check or in Federal Funds prior to the regular close of
    the NYSE on such day.
 
    Federal Funds purchase orders will  be accepted only on  a day on which  the
    Fund  and Chase (the "Custodian Bank") are  open for business. Your bank may
    charge a service fee for wiring Federal funds.
 
3) BY BANK WIRE.   The  same procedure outlined  under "By  Federal Funds  Wire"
   above  must be  followed in  purchasing shares  by bank  wire. However, money
   transferred by bank wire may or may  not be converted into Federal Funds  the
   same  day, depending on the time the  money is received and the bank handling
   the wire. Prior to such conversion, an investor's money will not be invested.
   Your bank may charge a service fee for wiring funds.
 
                                       35
<PAGE>
ADDITIONAL INVESTMENTS
 
    You may  add to  your account  at any  time (minimum  additional  investment
$1,000  for each portfolio,  except for automatic  reinvestment of dividends and
capital gains  distributions for  which  there are  no minimums)  by  purchasing
shares  at net asset  value by mailing a  check to the  Fund (payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio  name]") at the above address  or
by  wiring monies to the Custodian Bank  as outlined above. It is very important
that your account name, the portfolio  name and the class selected be  specified
in  the letter or wire  to assure proper crediting to  your account. In order to
ensure that your wire orders are invested promptly, you are requested to  notify
one  of the Fund's representatives (toll free: 1-800-548-7786) prior to the wire
date. Additional investments will  be applied to  purchase additional shares  in
the same class held by a shareholder in a Portfolio account.
 
OTHER PURCHASE INFORMATION
 
    Although  the legal rights of Class A  and Class B shares will be identical,
the different expenses borne  by each class will  result in different net  asset
values  and dividends. The net  asset value of Class  B shares will generally be
lower than the net asset value of Class A shares as a result of the distribution
expense charged to Class B shares. It  is expected, however, that the net  asset
value  per share of the two classes  will tend to converge immediately after the
recording of dividends  which will  differ by  approximately the  amount of  the
distribution expense accrual differential between the classes.
 
    In  the interest  of economy and  convenience, and because  of the operating
procedures of the  Fund, certificates  representing shares  of the  Portfolio(s)
will  not be issued. All  shares purchased are confirmed  to you and credited to
your account on the Fund's  books maintained by the  Adviser or its agents.  You
will  have  the same  rights and  ownership with  respect to  such shares  as if
certificates had been issued.
 
    To ensure that checks are collected by the Fund, withdrawals of  investments
made  by check are  not presently permitted  until payment for  the purchase has
been received,  which may  take up  to eight  business days  after the  date  of
purchase.  As a  condition of this  offering, if  a purchase is  canceled due to
nonpayment or because your check does not clear, you will be responsible for any
loss the Fund or its  agents incur. If you are  already a shareholder, the  Fund
may  redeem shares from your account(s) to  reimburse the Fund or its agents for
any loss. In addition,  you may be prohibited  or restricted from making  future
purchases in the Fund.
 
    Investors  may  also invest  in the  Fund by  purchasing shares  through the
Distributor.
 
EXCESSIVE TRADING
 
    Frequent  trades  involving  either   substantial  portfolio  assets  or   a
substantial  portion of your  account or accounts controlled  by you can disrupt
management of a portfolio and raise its expenses. Consequently, in the  interest
of  all the stockholders of each  Portfolio and the Portfolios' performance, the
Fund may in its discretion bar  a stockholder that engages in excessive  trading
of  shares of any class  of a portfolio from further  purchases of shares of the
Fund for an indefinite period. The  Fund considers excessive trading to be  more
than  one purchase and sale involving shares of the same class of a portfolio of
the Fund  within  any  120-day  period. As  an  example,  exchanging  shares  of
portfolios  of  the Fund  as follows  amounts  to excessive  trading: exchanging
shares of  Portfolio A  for shares  of Portfolio  B, then  exchanging shares  of
Portfolio B for shares of Portfolio C and again exchanging shares of Portfolio C
for shares of Portfolio B within a 120-day period. Two types of transactions are
 
                                       36
<PAGE>
exempt from these excessive trading restrictions: (1) trades exclusively between
money  market  portfolios;  and (2)  trades  done  in connection  with  an asset
allocation service, such as TFM Accounts  or accounts managed or advised by  the
Adviser and/or any of its affiliates.
 
INVESTMENT IN FUNDS THROUGH A TOTAL FUNDS MANAGEMENT ("TFM") ACCOUNT
 
    In  addition to the considerable diversification among individual securities
you receive by investing in a particular Portfolio, you can further reduce  risk
by  spreading  your assets  among several  different  Portfolios that  each have
different  risk  and  return  characteristics.  TFM  is  an  active   investment
management service managed by Morgan Stanley or its affiliates, including Morgan
Stanley  Asset  Management Inc.  (each, a  "TFM  Adviser"), that  allocates your
investments across a combination of either Class A or Class B shares of  certain
of  the Portfolios selected to meet your long-term investment objectives as well
as, in certain circumstances, your current income objectives.
 
    The TFM Adviser has developed investment strategies for TFM Accounts to meet
the diverse financial needs of different  investors. You can open a TFM  Account
by  meeting with one  of the investment professionals  of a Participating Dealer
who will review your situation and  help you identify your long-term  investment
and/or  current income  objectives. After using  TFM criteria  to determine your
long-term investment and/or  current income  objectives, you can  choose one  of
several  TFM investment strategies. Based on  your chosen strategy, your initial
investment will be allocated among a number of the Class A or Class B shares  of
the  Portfolios. Depending  on market  conditions, the  TFM Adviser periodically
reallocates the combination of Portfolios or the percentage amounts invested  in
the  shares  of each  Portfolio to  implement your  TFM investment  strategy. In
addition, your TFM Account will be periodically rebalanced to maintain your  TFM
strategy's  current asset allocation mix, if and  when the performance of one or
more of  the Portfolios  unbalances the  strategy's mix.  You will  pay the  TFM
Adviser  a fee for the  TFM Account service that is  in addition to and separate
from the fees and expenses you will pay directly or indirectly as an investor in
the Portfolios. See "Fund Expenses."
 
    From time to time, one or more of the Portfolios used for investment by  the
TFM  Accounts may experience relatively large  investments or redemptions due to
the TFM  Account allocations  or rebalancings  recommended by  the TFM  Adviser.
These  transactions will affect the Portfolios, since Portfolios that experience
redemptions as  a result  of  reallocations or  rebalancings  may have  to  sell
portfolio  securities and Portfolios  that receive additional  cash will have to
invest it in additional portfolio securities. While it is impossible to  predict
the  overall  impact of  these transactions  over time,  there could  be adverse
effects on portfolio management to the extent that Portfolios may be required to
sell securities or invest  cash at times  when they would  not otherwise do  so.
These  transactions  could also  have tax  consequences  if sales  of securities
resulted in  gains  and could  also  increase transaction  costs.  The  Adviser,
representing  the interests  of the Portfolios,  is committed  to minimizing the
impact of TFM Account transactions on the Portfolios. The Adviser, however, will
have a conflict in fulfilling  this responsibility in that  it also serves as  a
TFM  Adviser. In that  capacity, the Adviser, representing  the interests of the
TFM Accounts,  also  is  committed  to minimizing  the  impact  of  TFM  Account
transactions  on  the  Portfolios to  the  extent consistent  with  pursuing the
investment objectives of the TFM Accounts. In addition, an affiliate of the  TFM
Adviser,  the Distributor is compensated on  the sale,and may be compensated for
distribution or shareholder services  on the sale of  shares of the  Portfolios.
See  "Purchase of Shares"  and "Shareholder Services  -- Exchange Features." The
Adviser will monitor the impact of TFM Account transactions on the Portfolios.
 
                                       37
<PAGE>
                              REDEMPTION OF SHARES
 
    You may  withdraw all  or  any portion  of the  amount  in your  account  by
redeeming shares at any time. Please note that redemption proceeds for purchases
made  by check may not  be received until the payment  of the purchase price has
been collected, which  may take up  to eight business  days after purchase.  The
Fund  will redeem Class A shares or Class B shares of each Portfolio at the next
determined net asset value of shares of the applicable class. On days that  both
the  NYSE and the Custodian Bank are open  for business, the net asset value per
share of each of the Portfolios is determined at the regular close of trading of
the NYSE (currently  4:00 p.m. Eastern  Time). Shares of  the Portfolios may  be
redeemed  by mail or telephone. No charge is made for redemption. Any redemption
proceeds may be more or  less than the purchase  price of your shares  depending
on,  among other factors, the market value  of the investment securities held by
the Portfolio.
 
BY MAIL
 
    Each Portfolio will redeem its  Class A or Class B  shares at the net  asset
value determined on the date the request is received, if the request is received
in  "good order" before  the regular close  of the NYSE.  Your request should be
addressed to Morgan  Stanley Institutional  Fund, Inc., P.O.  Box 2798,  Boston,
Massachusetts  02208-2798, except that deliveries by overnight courier should be
addressed to Morgan  Stanley Institutional  Fund, Inc., c/o  Chase Global  Funds
Services Company, 73 Tremont Street, Boston, Massachusetts 02108-3913.
 
    "Good  order"  means that  the  request to  redeem  shares must  include the
following documentation:
 
         (a) A letter of instruction or a stock assignment specifying the  class
    and  number  of  shares or  dollar  amount  to be  redeemed,  signed  by all
    registered owners  of  the shares  in  the exact  names  in which  they  are
    registered;
 
        (b)   Any  required   signature  guarantees   (see  "Further  Redemption
    Information" below); and
 
         (c) Other  supporting legal  documents,  if required,  in the  case  of
    estates,  trusts, guardianships,  custodianships, corporations,  pension and
    profit sharing plans and other organizations.
 
    Shareholders who are uncertain of requirements for redemption should consult
with a Fund representative.
 
BY TELEPHONE
 
    Provided you have previously elected the Telephone Redemption Option on  the
Account  Registration  Form, you  can  request a  redemption  of your  shares by
calling the Fund  and requesting  the redemption proceeds  be mailed  to you  or
wired to your bank. Please contact one of the Fund's representatives for further
details.  In times of drastic market conditions, the telephone redemption option
may be  difficult  to  implement.  If you  experience  difficulty  in  making  a
telephone  redemption, your request may be made by mail or express mail and will
be implemented at  the net  asset value next  determined after  it is  received.
Redemption  requests sent to the Fund through express mail must be mailed to the
address of  the Dividend  Disbursing and  Transfer Agent  listed under  "General
Information." The Fund and the Fund's transfer agent (the "Transfer Agent") will
employ  reasonable procedures to  confirm that the  instructions communicated by
telephone are  genuine.  These  procedures include  requiring  the  investor  to
provide  certain personal identification  information at the  time an account is
opened and  prior  to effecting  each  transaction requested  by  telephone.  In
addition,  all telephone transaction requests will be recorded and investors may
be   required   to   provide   additional   telecopied   written    instructions
 
                                       38
<PAGE>
regarding  transaction requests. Neither the Fund nor the Transfer Agent will be
responsible for any loss, liability, cost or expense for following  instructions
received by telephone that either of them reasonably believes to be genuine.
 
    To  change the commercial  bank or account  designated to receive redemption
proceeds, a written  request must  be sent  to the  Fund at  the address  above.
Requests  to change the bank  or account must be  signed by each shareholder and
each signature must be guaranteed.
 
FURTHER REDEMPTION INFORMATION
 
    Normally the  Fund will  make payment  for all  shares redeemed  within  one
business  day of receipt  of the request, but  in no event  will payment be made
more than  seven days  after receipt  of  a redemption  request in  good  order.
However,  payments to investors  redeeming shares which  were purchased by check
will not be made until  payment for the purchase  has been collected, which  may
take up to eight days after the date of purchase. The Fund may suspend the right
of  redemption or postpone the date upon which redemptions are effected at times
when the NYSE is closed, or  under any emergency circumstances as determined  by
the Securities and Exchange Commission (the "Commission").
 
    If  the Board of  Directors determines that  it would be  detrimental to the
best interests of  the remaining  shareholders of  a Portfolio  to make  payment
wholly  or partly in cash, the Fund may  pay the redemption proceeds in whole or
in part by a distribution in-kind of securities held by the Portfolio in lieu of
cash   in    conformity   with    applicable    rules   of    the    Commission.
Distributions-in-kind  will be made in  readily marketable securities. Investors
may incur brokerage charges on the  sale of portfolio securities so received  in
payment of redemptions.
 
    To  protect  your account,  the Fund  and its  agents from  fraud, signature
guarantees are required for  certain redemptions to verify  the identity of  the
person  who has  authorized a redemption  from your account.  Please contact the
Fund for further  information. See "Redemption  of Shares" in  the Statement  of
Additional Information.
 
                              SHAREHOLDER SERVICES
 
EXCHANGE FEATURES
 
    You  may exchange shares that you own  in either portfolio for shares of any
other available portfolio(s) of  the Fund (other  than the International  Equity
Portfolio,  which is  closed to  new investors). In  exchanging for  shares of a
portfolio with more  than one  class, the  class of  shares you  receive in  the
exchange  will be determined in the same  manner as any other purchase of shares
and will not  be based  on the  class of  shares surrendered  for the  exchange.
Consequently,  the same minimum initial investment  and minimum account size for
determining the  class  of shares  received  in  the exchange  will  apply.  See
"Purchase of Shares" above. Shares of the portfolios may be exchanged by mail or
telephone.  The privilege to exchange shares  by telephone is automatic and made
available without shareholder election. Before you make an exchange, you  should
read  the prospectus of the portfolio(s) in which you seek to invest. Because an
exchange transaction  is treated  as a  redemption followed  by a  purchase,  an
exchange  would be considered  a taxable event for  shareholders subject to tax.
The exchange privilege may  be modified or  terminated by the  Fund at any  time
upon 60-days notice to shareholders.
 
                                       39
<PAGE>
BY MAIL
 
    In  order to  exchange shares  by mail, you  should include  in the exchange
request the name, class of shares and account number of your current  Portfolio,
the  names of the portfolio(s) and class(es)  of shares into which you intend to
exchange shares, and the signatures of all registered account holders. Send  the
exchange  request to  Morgan Stanley  Institutional Fund,  Inc., P.O.  Box 2798,
Boston, Massachusetts 02208-2798.
 
BY TELEPHONE
 
    When exchanging shares by  telephone, have ready the  name, class of  shares
and  account number of  your current portfolio, the  name(s) of the portfolio(s)
and class(es) of shares  into which you intend  to exchange shares, your  Social
Security  number  or Tax  I.D. number,  and your  account address.  Requests for
telephone exchanges received prior to 4:00 p.m. (Eastern Time) are processed  at
the close of business that same day based on the net asset value of the class of
each  of  the portfolios  involved in  the exchange  of shares  at the  close of
business. Requests received  after 4:00  p.m. (Eastern Time)  are processed  the
next  business  day based  on the  net asset  value determined  at the  close of
business on such  day. For additional  information regarding responsibility  for
the  authenticity of  telephoned instructions, see  "Redemption of  Shares -- By
Telephone" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by writing  to Morgan  Stanley Institutional  Fund Inc.,  P.O. Box  2798,
Boston,  Massachusetts 02208-2798.  As in the  case of  redemptions, the written
request must  be  received  in good  order  before  any transfer  can  be  made.
Transferring  the  registration of  shares may  affect  the eligibility  of your
account for  a  given  class  of  each Portfolio's  shares  and  may  result  in
involuntary  conversion or redemption  of your shares.  See "Purchase of Shares"
above.
 
                              VALUATION OF SHARES
 
    The net asset  value per share  of a class  of shares of  the Portfolios  is
determined by dividing the total market value of the Portfolio's investments and
other  assets attributable to  such class, less  any liabilities attributable to
such class, by  the total  number of  outstanding shares  of such  class of  the
Portfolio.  Net  asset value  is  calculated separately  for  each class  of the
Portfolio. Net asset value per  share is determined as  of the regular close  of
the  NYSE on each day  that the NYSE is open  for business. Price information on
listed securities is  taken from the  exchange where the  security is  primarily
traded.  Securities  listed  on  a U.S.  securities  exchange  for  which market
quotations are available are valued at the last quoted sale price on the day the
valuation is made. Securities listed on  a foreign exchange are valued at  their
closing  price.  Unlisted securities  and listed  securities  not traded  on the
valuation date for which market quotations are readily available are valued at a
price within a range  not exceeding the  current asked price  nor less than  the
current  bid price. The current bid and asked prices are determined based on the
average of the bid and asked prices  quoted on such valuation date by  reputable
brokers.
 
    Bonds and other fixed income securities are valued according to the broadest
and  most representative market,  which will ordinarily  be the over-the-counter
market. Net asset value includes interest  on fixed income securities, which  is
accrued  daily.  In addition,  bonds and  other fixed  income securities  may be
valued on the basis of prices provided by a pricing service when such prices are
believed to  reflect  the fair  market  value  of such  securities.  The  prices
provided  by a pricing service are determined without regard to bid or last sale
prices, but take into account institutional  size, trading in similar groups  of
securities and any developments related to the
 
                                       40
<PAGE>
specific securities. Securities not priced in this manner are valued at the most
recently  quoted bid price, or when  securities exchange valuations are used, at
the latest  quoted sale  price on  the day  of valuation.  If there  is no  such
reported  sale, the latest  quoted bid price will  be used. Securities purchased
with remaining maturities of 60 days or less are valued at amortized cost, if it
approximates market value. In the event that amortized cost does not approximate
market value, market prices as determined above will be used.
 
    The value  of other  assets  and securities  for  which quotations  are  not
readily  available (including  restricted and  unlisted foreign  securities) and
those  securities  for  which  it  is  inappropriate  to  determined  prices  in
accordance with the above-stated procedures are determined in good faith at fair
value  using  methods determined  by  the Board  of  Directors. For  purposes of
calculating net  asset value  per share,  all assets  and liabilities  initially
expressed in foreign currencies will be translated into U.S. dollars at the mean
of  the bid  and asked  price of  such currencies  against the  U.S. dollar last
quoted by any major bank.
 
    Although the legal rights of Class A  and Class B shares will be  identical,
the  different expenses borne by  each class will result  in different net asset
values and dividends for the class.  Dividends will differ by approximately  the
amount  of the distributions expense accrual differential among the classes. The
net asset value of  Class B shares  will generally be lower  than the net  asset
value  of the Class A shares as a  result of the distribution expense charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise the total return for each class  of
the  Portfolios.  THESE FIGURES  ARE BASED  ON HISTORICAL  EARNINGS AND  ARE NOT
INTENDED TO INDICATE FUTURE PERFORMANCE.
 
    "Total return" shows what  an investment in a  class of the Portfolio  would
have  earned over a specified  period of time (such as  one, five or ten years),
assuming that all distributions and  dividends by the Portfolio were  reinvested
in the same class on the reinvestment dates during the period. Total return does
not  take into account any federal or state  income taxes that may be payable on
dividends and  distributions  or upon  redemption.  The Fund  may  also  include
comparative  performance information in advertising or marketing the Portfolios'
shares, including data  from Lipper  Analytical Services,  Inc., other  industry
publications, business periodicals, rating services and market indices.
 
    The  performance figures  for Class  B shares  will generally  be lower than
those for Class  A shares because  of the  distribution fee charged  to Class  B
shares.
 
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All  income dividends and capital gains  distributions for a class of shares
will be automatically reinvested in additional shares at net asset value, except
that, upon written notice to the Fund or by checking off the appropriate box  in
the  Distribution Option Section on the Account Registration Form, a shareholder
may elect to receive income dividends and capital gains distributions in cash.
 
    Each Portfolio expects to  distribute substantially all  of its taxable  net
investment income in the form of annual dividends. Net realized capital gains of
each Portfolio, if any, after reduction for any tax loss carryforwards will also
be distributed annually.
 
                                       41
<PAGE>
    Undistributed  net  investment income  is included  in each  Portfolio's net
assets for the purpose of calculating  net asset value per share. Therefore,  on
the  "ex-dividend" date,  the net  asset value  per share  excludes the dividend
(I.E., is  reduced by  the per  share amount  of the  dividend). Dividends  paid
shortly after the purchase of shares by an investor, although in effect a return
of capital, are taxable to shareholders subject to income tax.
 
    Because  of  the  distribution  fee  and  any  other  expenses  that  may be
attributable to  the Class  B shares,  the net  income attributable  to and  the
dividends  payable  on  Class  B  shares  will  be  lower  than  the  net income
attributable to and the dividends  payable on Class A  shares. As a result,  the
net asset value per share of the classes of each Portfolio will differ at times.
Expenses  of each Portfolio  allocated to a  particular class of  shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to  present a detailed explanation of the  federal,
state,  or  local  income tax  treatment  of  a Portfolio  or  its shareholders.
Accordingly, shareholders  are urged  to consult  their tax  advisors  regarding
specific questions as to federal, state and local income taxes.
 
    Each  Portfolio  is treated  as  a separate  entity  for federal  income tax
purposes and is not  combined with the Fund's  other portfolios. Each  Portfolio
intends  to qualify for the special  tax treatment afforded regulated investment
companies under Subchapter M of the Code, so that the Portfolio will be relieved
of federal income tax on that part of its net investment income and net  capital
gain that is distributed to shareholders.
 
    Each  Portfolio intends to  distribute substantially all  of its taxable net
investment income (including, for this purpose, net short-term capital gain)  to
shareholders.  Dividends from a Portfolio's net investment income are taxable to
shareholders as  ordinary income,  whether  received in  cash or  in  additional
shares.  Such dividends paid by  a Portfolio generally will  qualify for the 70%
dividends-received deduction  for corporate  shareholders. Each  Portfolio  will
report annually to its shareholders the amount of dividend income qualifying for
such treatment.
 
    Distributions  of net capital gain (the excess of net long-term capital gain
over net  short-term capital  loss)  are taxable  to shareholders  as  long-term
capital  gain, regardless of how long  shareholders have held their shares. Each
Portfolio will send reports annually to  shareholders of the federal income  tax
status of all distributions made during the preceding year.
 
    Each   Portfolio  intends   to  make  sufficient   distributions  or  deemed
distributions of its ordinary income and capital gain net income (the excess  of
short-term  and  long-term capital  gain over  short-term and  long-term capital
losses, including any available capital loss carryforwards), prior to the end of
each calendar year to avoid liability for federal excise tax.
 
    Dividends and  other  distributions  declared by  a  Portfolio  in  October,
November or December of any year and payable to shareholders of record on a date
in  such month will be deemed to have been paid by the Portfolio and received by
the shareholders on December 31  of that year if  the distributions are paid  by
the Portfolio at any time during the following January.
 
                                       42
<PAGE>
    The  Fund may be required to withhold and  remit to the U.S. Treasury 31% of
any dividends, capital gains distributions  and redemption proceeds paid to  any
individual  or certain  other non-corporate  shareholder (1)  who has  failed to
provide a  correct taxpayer  identification  number (generally  an  individual's
social  security number  or non-individual's employer  identification number) on
the Application Form, (2) who is  subject to backup withholding by the  Internal
Revenue  Service, or (3) who has not certified to the Fund that such shareholder
is not  subject  to  backup  withholding. This  backup  withholding  is  not  an
additional   tax,  and  any  amounts  withheld   may  be  credited  against  the
shareholder's ultimate U.S. tax liability.
 
    The sale, exchange or  redemption of shares will  result in taxable gain  or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the sale, exchange or redemption proceeds exceed or are
less  than the shareholder's  adjusted basis in the  sold, exchanged or redeemed
shares. If capital gain distributions have been made with respect to shares that
are sold at a  loss after being held  for six months or  less, then the loss  is
treated  as  a  long-term  capital  loss  to  the  extent  of  the  capital gain
distributions.
 
    Conversion  of  shares  between  classes  are  not  taxable  events  to  the
shareholder.
 
    Shareholders  are urged  to consult with  their tax  advisors concerning the
application of state and local income taxes to investments in a Portfolio, which
may differ from the federal income tax consequences described above.
 
    Investment income  received  by  a Portfolio  from  sources  within  foreign
countries  may be subject to foreign income taxes withheld at the source. To the
extent that a  Portfolio is liable  for foreign income  taxes so withheld,  each
Portfolio  intends to operate so as to meet the requirements of the Code to pass
through to the shareholders credit for foreign income taxes paid. Although  each
Portfolio  intends to  meet Code  requirements to  pass through  credit for such
taxes, there can be no assurance that each Portfolio will be able to do so.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO  THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN THE PORTFOLIO.
 
                             PORTFOLIO TRANSACTIONS
 
    The  Adviser selects the brokers or  dealers that will execute the purchases
and sales  of investment  securities  for each  of  the Fund's  portfolios.  The
Adviser  seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser  believes
it  is reasonable to do  so in light of the  value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which  may be made through intermediary brokers  or
dealers.  However, the Adviser may, consistent  with NASD rules, place portfolio
orders with qualified broker-dealers who  recommend the applicable portfolio  to
their  clients or who act  as agents in the purchase  of shares of the portfolio
for their clients.
 
    Subject to  the overriding  objective  of obtaining  the best  execution  of
orders,  the Fund  may use  broker-dealer affiliates  of the  Adviser, including
Morgan Stanley,  to effect  portfolio  brokerage transactions  under  procedures
adopted  by the Fund's Board of Directors. For such transactions, the commission
rates and other
 
                                       43
<PAGE>
remuneration paid  to  Morgan Stanley  or  other  affiliates must  be  fair  and
reasonable  in  comparison  to  those  of  other  broker-dealers  for comparable
transactions involving  similar  securities being  purchased  or sold  during  a
comparable time period.
 
PORTFOLIO TURNOVER
 
    The  Portfolios  generally do  not invest  for short-term  trading purposes,
however,  when  circumstances  warrant,  each  Portfolio  may  sell   investment
securities  without regard  to the  length of time  they have  been held. Market
conditions in a given year could result in a higher or lower portfolio  turnover
rate  than expected and the Portfolios will not consider portfolio turnover rate
a  limiting  factor  in  making  investment  decisions  consistent  with   their
respective objectives and policies. For the fiscal year ended December 31, 1996,
the  Emerging Markets Debt and Latin  American Portfolios had portfolio turnover
rates of  560% and  192%,  respectively. As  portfolio turnover  increases,  the
Portfolios  may expect  to pay  correspondingly increased  brokerage and trading
costs. In addition to transaction costs, higher portfolio turnover may result in
the realization of capital gains. As discussed under "Taxes," to the extent  net
short-term  capital gains  are realized,  any distributions  resulting from such
gains are considered ordinary income for federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund  was organized  as a  Maryland corporation  on June  16, 1988.  The
Articles  of Incorporation, as amended and restated, permit the Fund to issue up
to 38 billion shares of common stock,  with $.001 par value per share.  Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number  of shares the  Fund is authorized  to issue without  the approval of the
shareholders of the Fund. The Board of Directors has the power to designate  one
or  more classes of  shares of common  stock and to  classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of each
portfolio are currently classified into two classes, the Class A shares and  the
Class  B  shares,  except for  the  International  Small Cap,  Money  Market and
Municipal Money Market Portfolios which offer only Class A shares.
 
    The  shares  of   the  Portfolios,   when  issued,  will   be  fully   paid,
nonassessable,  fully transferable and  redeemable at the  option of the holder.
The shares have no preference as to conversion, exchange, dividends,  retirement
or  other features and have no pre-emptive  rights. The shares of each Portfolio
have non-cumulative voting rights, which means that the holders of more than 50%
of the  shares voting  for  the election  of Directors  can  elect 100%  of  the
Directors  if they choose to do so.  Persons or organizations owning 25% or more
of the outstanding shares of a Portfolio  may be presumed to "control" (as  that
term is defined in the 1940 Act) that Portfolio. Under Maryland law, the Fund is
not required to hold an annual meeting of its shareholders unless required to do
so under the 1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The  Fund will  send to its  shareholders annual,  semi-annual and quarterly
reports; the financial  statements appearing  in annual reports  are audited  by
independent accountants. Monthly unaudited portfolio data is also available from
the Fund upon request.
 
    In addition, the Adviser, or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
                                       44
<PAGE>
CUSTODIAN
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is  not an  affiliate of  the Adviser or  the Distributor.  Morgan Stanley Trust
Company, Brooklyn,  New York  ("MSTC"),  an affiliate  of  the Adviser  and  the
Distributor,  acts as  the Fund's custodian  for assets held  outside the United
States and employs sub-custodians approved by the Board of Directors of the Fund
in accordance with regulations of the Securities and Exchange Commission for the
purpose of providing  custodial services  for such  assets. MSTC  may also  hold
certain  domestic assets for  the Fund. For more  information on the custodians,
see "General Information -- Custody Arrangements" in the Statement of Additional
Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase  Global   Funds  Services   Company,   73  Tremont   Street,   Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price  Waterhouse LLP  serves as  independent accountants  for the  Fund and
audits its annual financial statements.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       45
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
  EMERGING MARKETS, EMERGING MARKETS DEBT AND LATIN AMERICAN PORTFOLIOS
   P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                            <C>
      ACCOUNT INFORMATION                            If you need assistance in filling out this form for the Morgan Stanley
      Fill in where applicable                       Institutional Fund, please contact your Morgan Stanley representative
                                                     or call us toll free 1-800-548-7786. Please print all items except
                                                     signature, and mail to the Fund at the address above.
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
         TENANCY IN COMMON
         IS INDICATED)
</TABLE>
 
1.
         First Name    Initial         Last Name
2.
         First Name    Initial         Last Name
         First Name    Initial         Last Name
 
<TABLE>
<C>   <S>                                            <C>
      3. CORPORATIONS,
         TRUSTS AND OTHERS
         Please call the Fund for additional
      documents that may be required to set up
      account and to authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                     <C>                 <C>                   <C>               <C>
Type of Registration:   / / INCORPORATED    / / UNINCORPORATED    / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                            ASSOCIATION                               (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
 
<TABLE>
<C>   <S>                                            <C>
  B)  MAILING ADDRESS
      Please fill in completely, including
      telephone number(s).
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
/ / Non-Resident Alien:
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
 
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
 
<TABLE>
<C>   <S>                                            <C>                                  <C>
  C)  TAXPAYER                                       Enter   your  Taxpayer   Identification  Number.   For  most  individual
      IDENTIFICATION                                 taxpayers, this is your Social Security Number.
      NUMBER
      1. INDIVIDUAL
      2.   JOINT TENANTS
           (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
           TENANCY IN COMMON
           IS INDICATED)
      For Custodian account
      of a minor (Uniform
      Gifts/Transfers to Minor
      Acts), give the Social
      Security Number of
      the minor
                                                                                          OR
                                                     1.         TAXPAYER IDENTIFICATION                      SOCIAL SECURITY
                                                     NUMBER ("TIN")                                NUMBER ("SSN")
                                                                                              OR
                                                     2.                                                          TIN
                                                                                                                             SSN
                                                                                              OR
                                                     TIN
                                                                                                                             SSN
                                                     IMPORTANT TAX INFORMATION
                                                     You  (as a payee) are required by law to provide us (as payer) with your
                                                     correct TIN(s)  or SSN(s).  Accounts that  have a  missing or  incorrect
                                                     TIN(s)  or SSN(s) will be subject to backup withholding at a 31% rate on
                                                     dividends, distributions and other payments. If you have not provided us
                                                     with your correct TIN(s) or SSN(s), you may be subject to a $50  penalty
                                                     imposed by the Internal Revenue Service.
                                                     Backup  withholding  is  not an  additional  tax; the  tax  liability of
                                                     persons subject to backup withholding will  be reduced by the amount  of
                                                     tax  withheld.  If withholding  results in  an  overpayment of  taxes, a
                                                     refund may be obtained.
                                                     You may be  notified that you  are subject to  backup withholding  under
                                                     Section  3406(a)(1)(C)  of the  Internal Revenue  Code because  you have
                                                     underreported interest or dividends or you were required to, but  failed
                                                     to,  file a  return which would  have included a  reportable interest or
                                                     dividend payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>                             <C>                   <C>
  D)  PORTFOLIO AND                        For Purchase of the following   / / Class A Shares $  / / Class B Shares $
      CLASS SECTION                        Portfolio(s):                   / / Class A Shares $  / / Class B Shares $
      (Class A shares minimum $500,000     Emerging Markets Portfolio      / / Class A Shares $  / / Class B Shares $
      for each Portfolio and Class B       Emerging Markets Debt
      shares minimum $100,000 for each     Portfolio
      Portfolio.) Please indicate          Latin American Portfolio
      Portfolio, class and amount.
                                                                           Total Initial Investment $
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate
      portfolio, manner of
      payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                          <C>
/ / Exchange $ From                                                                     - - - - - - - - - - - -- - -
                            Name of Portfolio                                                   Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on                 -- - - - - - - - - - -- - -
                                                                                       Account No.            (Check
                                                                                (Previously assigned by the Fund)     Digit)
                                                                                                                          Date
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  F)  DISTRIBUTION               Income dividends and capital gains distributions (if any) to
      OPTION                     be reinvested in additional shares unless either box below
                                 is checked.
                                 / / Income dividends to be paid in cash, capital gains
                                 distributions (if any) in shares.
                                 / / Income dividends and capital gains distributions (if
                                 any) to be paid in cash.
</TABLE>
 
<TABLE>
<C>   <S>                             <C>                                       <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone         Name of Commercial Bank (Not Savings
      AND EXCHANGE                    requests to wire redemption proceeds to   Bank)
      OPTION                          the commercial bank indicated at right    Bank Account No.
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund
      wish to redeem or exchange      account is registered if such requests                                        Bank
      shares by telephone. A          are believed to be authentic.                                                  ABA
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent                                         No.
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated    Name(s) in which your Bank Account is
      YOUR FUND ACCOUNT.              by telephone are genuine. These           Established
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal      Bank's Street
      NOT BE HONORED UNLESS THE BOX   identification information at the time    Address
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by   City  State  Zip
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  H)  INTERESTED PARTY
      OPTION                                                                                                Name
      In addition to the account
      statement sent to my/our registered
      address, I/we hereby authorize the                                                                   Address
      Fund to mail duplicate statements
      to the name and address provided at  City         State         Zip Code
      right.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  I)  DEALER
      INFORMATION
                                           Representative Name              Representative No.             Branch
                                           No.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here ,
</TABLE>
 
<TABLE>
<S>                                  <C>
The undersigned certify that I/we have full authority and legal capacity
to purchase and redeem shares of the Fund and affirm that I/we have
received a current Prospectus of the Morgan Stanley Institutional Fund,
Inc. and agree to be bound by its terms.
  BY SIGNING THIS  APPLICATION, I/WE HEREBY  CERTIFY UNDER PENALTIES  OF
PERJURY THAT THE INFORMATION ON THIS APPLICATION IS COMPLETE AND CORRECT
AND  THAT  AS REQUIRED  BY FEDERAL  LAW  (PLEASE CHECK  APPLICABLE BOXES
BELOW):
 
/ / U.S. CITIZEN(S)/TAXPAYER(S):
 
      / / I/WE CERTIFY THAT (1)  THE NUMBER(S) SHOWN ABOVE ON THIS  FORM
          IS/ARE  THE  CORRECT SSN(S)  OR TIN(S)  AND  (2) I/WE  ARE NOT
          SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE  ARE
          EXEMPT  FROM  BACKUP  WITHHOLDING;  (B)  I/WE  HAVE  NOT  BEEN
          NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT I/WE ARE
          SUBJECT TO  BACKUP WITHHOLDING  AS A  RESULT OF  A FAILURE  TO
          REPORT  ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED
          ME/US  THAT  I   AM/WE  ARE  NO   LONGER  SUBJECT  TO   BACKUP
          WITHHOLDING.
 
      / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE HAVE
          APPLIED, OR INTEND TO APPLY, TO THE IRS OR THE SOCIAL SECURITY
          ADMINISTRATION  FOR A TIN OR A SSN AND I/WE UNDERSTAND THAT IF
          I/ WE  DO NOT  PROVIDE  EITHER NUMBER  TO CHASE  GLOBAL  FUNDS
          SERVICES  COMPANY ("CGFSC") WITHIN 60 DAYS OF THE DATE OF THIS
          APPLICATION OR IF I/WE FAIL  TO FURNISH MY/OUR CORRECT  SSN(S)
          OR  TIN(S), I/WE MAY BE SUBJECT TO  A PENALTY AND A 31% BACKUP
          WITHHOLDING ON DISTRIBUTIONS AND REDEMPTION PROCEEDS.  (PLEASE
          PROVIDE  EITHER NUMBER ON IRS FORM  W-9). YOU MAY REQUEST SUCH
          FORM BY CALLING CGFSC AT 800-282-4404.
 
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
  UNDER PENALTIES  OF  PERJURY, I/WE  CERTIFY  THAT I/WE  ARE  NOT  U.S.
CITIZENS  OR RESIDENTS AND I/WE ARE EXEMPT FOREIGN PERSONS AS DEFINED BY
THE INTERNAL REVENUE SERVICE.
 
THE INTERNAL  REVENUE  SERVICE DOES  NOT  REQUIRE YOUR  CONSENT  TO  ANY
PROVISION  OF THIS  DOCUMENT OTHER  THAN THE  CERTIFICATIONS REQUIRED TO
AVOID BACKUP WITHHOLDING.
 
                                     (X)
(X)                                  Signature (if joint account, both
Signature                        Date must sign)      Date
</TABLE>
<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO  DEALER, SALES  REPRESENTATIVE OR ANY  OTHER PERSON HAS  BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE  CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS  HAVING BEEN AUTHORIZED BY THE FUND  OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF  THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION  TO
ANY  PERSON TO WHOM  IT IS UNLAWFUL TO  MAKE SUCH OFFER  OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<S>                                                 <C>
                                                    PAGE
                                                    ----
Fund Expenses.....................................    2
Financial Highlights..............................    4
Prospectus Summary................................    8
Investment Objectives and Policies................   12
Additional Investment Information.................   18
Investment Limitations............................   30
Management of the Fund............................   30
Purchase of Shares................................   33
Redemption of Shares..............................   38
Shareholder Services..............................   39
Valuation of Shares...............................   40
Performance Information...........................   41
Dividends and Capital Gains Distributions.........   41
Taxes.............................................   42
Portfolio Transactions............................   43
General Information...............................   44
Account Registration Form
</TABLE>
 
                           EMERGING MARKETS PORTFOLIO
                        EMERGING MARKETS DEBT PORTFOLIO
                            LATIN AMERICAN PORTFOLIO
 
                               PORTFOLIOS OF THE
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
 
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  Incorporated
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
                      P.O. BOX 2798, BOSTON, MA 02208-2798
<PAGE>
- ---------------------------------------
- ---------------------------------------
- ---------------------------------------
- ---------------------------------------
<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
- --------------------------------------------------------------------------------
 
                            GLOBAL EQUITY PORTFOLIO
                         INTERNATIONAL EQUITY PORTFOLIO
                       INTERNATIONAL SMALL CAP PORTFOLIO
                           EUROPEAN EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
 
                                ----------------
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a series of diversified and non-diversified investment portfolios
("portfolios"). The Fund is designed to provide clients with attractive
alternatives for meeting their investment needs. The Fund currently consists of
thirty-two portfolios representing a broad range of investment choices. This
prospectus (the "Prospectus") pertains to the Class A and the Class B shares of
the Global Equity, International Equity, and European Equity Portfolios (each a
"Multiclass Portfolio" and collectively, the "Multiclass Portfolios") and to the
Class A Shares of the International Small Cap Portfolio (each, a "Portfolio" and
collectively, the "Portfolios"). The International Equity Portfolio is currently
closed to new investors with the exception of certain Morgan Stanley & Co.
Incorporated ("Morgan Stanley") customers, employees of Morgan Stanley, certain
tax-qualified retirement plans and other investment companies advised by Morgan
Stanley Asset Management Inc. and its affiliates. The Class A and Class B shares
currently offered by the Portfolios have different minimum investment
requirements and fund expenses. Shares of the portfolios are offered with no
sales charge, exchange fee or redemption fee, (except that the International
Small Cap Portfolio may impose a transaction fee).
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator"), and with Morgan Stanley as Distributor, the Fund makes
available to institutional and high net worth individual investors a series of
portfolios which benefit from the investment expertise and commitment to
excellence associated with Morgan Stanley and its affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under "Prospectus Summary" below. The Fund
currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging Markets,
European Equity, European Real Estate, Global Equity, Gold, International
Equity, International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) EQUITY AND FIXED INCOME -- Balanced
Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global
Fixed Income, High Yield and Municipal Bond Portfolios; and (v) MONEY MARKET --
Money Market and Municipal Money Market Portfolios. Additional information about
the Fund is contained in a "Statement of Additional Information," dated May 1,
1997, as supplemented through September 26, 1997, which is incorporated herein
by reference. The Statement of Additional Information and the prospectuses
pertaining to the other portfolios of the Fund are available upon request and
without charge by writing or calling the Fund at the address and telephone
number set forth above.
 
 THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
   EXCHANGE COMMISSION, NOR HAS THE SECURITIES AND EXCHANGE COMMISSION
    PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY
             REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
                   THE DATE OF THIS PROSPECTUS IS MAY 1, 1997
                  AS SUPPLEMENTED THROUGH SEPTEMBER 26, 1997.
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates the expenses and fees that a shareholder of
each Portfolio listed below will incur.
 
<TABLE>
<CAPTION>
                                        GLOBAL EQUITY      INTERNATIONAL EQUITY    INTERNATIONAL SMALL      EUROPEAN EQUITY
SHAREHOLDER TRANSACTION EXPENSES          PORTFOLIO              PORTFOLIO            CAP PORTFOLIO            PORTFOLIO
- ----------------------------------  ---------------------  ---------------------  ---------------------  ---------------------
<S>                                 <C>                    <C>                    <C>                    <C>
Maximum Sales Load Imposed on
 Purchases
  Class A.........................             None                   None                   None*                  None
  Class B.........................             None                   None                    N/A                   None
Maximum Sales Load Imposed on
 Reinvested Dividends
  Class A.........................             None                   None                   None                   None
  Class B.........................             None                   None                    N/A                   None
Deferred Sales Load
  Class A.........................             None                   None                   None                   None
  Class B.........................             None                   None                    N/A                   None
Redemption Fees
  Class A.........................             None                   None                  1.00%*                  None
  Class B.........................             None                   None                    N/A                   None
Exchange Fees
  Class A.........................             None                   None                   None                   None
  Class B.........................             None                   None                    N/A                   None
</TABLE>
 
- --------------------------
* Shareholders of the International Small Cap Portfolio may be charged a 1.00%
  transaction fee, which is payable directly to the International Small Cap
  Portfolio, in connection with each purchase and redemption of shares of the
  Portfolio. The transaction fee is intended to allocate transaction costs
  associated with purchases and redemptions of shares of the Portfolio to
  investors actually making such purchases and redemptions rather than to the
  Portfolio's other shareholders. The 1.00% fee represents the Adviser's
  estimate of such transaction costs, which include the costs of acquiring and
  disposing of Portfolio securities. The transaction fee is not a sales charge
  or load, and is retained by the Portfolio. The fee does not apply to
  portfolios of the Fund other than the International Small Cap Portfolio and is
  not charged in connection with the reinvestment of dividends or capital gain
  distributions. The fee will not be charged with respect to purchases and
  redemptions that do not result in actual transaction costs to the Portfolio.
  Examples of such transactions include offsetting purchases and redemptions by
  different shareholders occurring at the same time and in-kind purchases and
  redemptions.
 
                                       2
<PAGE>
 
<TABLE>
<CAPTION>
                                                                          INTERNATIONAL
                                                     GLOBAL EQUITY           EQUITY         INTERNATIONAL SMALL   EUROPEAN EQUITY
ANNUAL FUND OPERATING EXPENSES                         PORTFOLIO            PORTFOLIO          CAP PORTFOLIO         PORTFOLIO
- ------------------------------------------------  -------------------  -------------------  -------------------  ------------------
 (AS A PERCENTAGE OF AVERAGE NET ASSETS)
<S>                                               <C>                  <C>                  <C>                  <C>
Management Fee (Net of Fee Waivers)**
  Class A.......................................           0.65%                0.78%                0.87%                0.64%
  Class B.......................................           0.65%                0.78%                  N/A                0.64%
12b-1 Fees
  Class A.......................................            None                 None                 None                 None
  Class B.......................................           0.25%                0.25%                  N/A                0.25%
Other Expenses
  Class A.......................................           0.35%                0.22%                0.28%                0.36%
  Class B.......................................           0.35%                0.22%                  N/A                0.36%
                                                         -------              -------              -------           ----------
Total Operating Expenses (Net of Fee Waivers)
  Class A.......................................           1.00%                1.00%                1.15%                1.00%
  Class B.......................................           1.25%                1.25%                  N/A                1.25%
                                                         -------              -------              -------           ----------
                                                         -------              -------              -------           ----------
</TABLE>
 
- --------------------------
 
 ** The Adviser has agreed to waive its management fees and/or reimburse each
    Portfolio, if necessary, if such fees would cause the total annual operating
    expenses of the Portfolios to exceed a specified percentage of their
    respective average daily net assets. As a result of these reductions, the
    Management Fees stated above are lower than the contractual fees stated
    under "Management of the Fund." The Adviser reserves the right to terminate
    any of its fee waivers and/or expense reimbursements at any time in its sole
    discretion. For further information on Fund expenses, see "Management of the
    Fund." Set forth below, for each Portfolio as applicable, are the management
    fees and total operating expenses absent such fee waivers and/or expense
    reimbursements as a percent of average daily net assets of the Class A
    shares of the Portfolios and Class B Shares of the Multiclass Portfolios,
    respectively.
 
<TABLE>
<CAPTION>
                                                                                             TOTAL
                                                                                       OPERATING EXPENSES
                                                                                             ABSENT
                                                                    MANAGEMENT            FEE WAIVERS
                                                                  FEES ABSENT FEE  --------------------------
PORTFOLIO                                                             WAIVERS        CLASS A       CLASS B
- ----------------------------------------------------------------  ---------------  ------------  ------------
<S>                                                               <C>              <C>           <C>
Global Equity...................................................         0.80%           1.15%         1.39%
International Equity............................................         0.80%           1.02%         1.27%
International Small Cap.........................................         0.95%           1.23%       N/A
European Equity.................................................         0.80%           1.16%         1.40%
</TABLE>
 
    The purpose of the table is to assist the investor in understanding the
various expenses that an investor in the Portfolios will bear directly or
indirectly. Expenses and fees are based on actual figures for the fiscal year
ended December 31, 1996. Due to the continuous nature of Rule 12b-1 fees,
long-term Class B shareholders may pay more than the equivalent of the maximum
front-end sales charges otherwise permitted by the National Association of
Securities Dealers, Inc. ("NASD") Conduct Rules.
 
                                       3
<PAGE>
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (1) a 5% annual rate of return and (2) redemption at
the end of each time period. As noted in the table above, the only fee charged
by the Fund upon purchase or redemption of Fund shares is the 1% transaction fee
that may be assessed on purchases and redemptions of shares of the International
Small Cap Portfolio, which charges are reflected in this example. The following
example is based on total operating expenses of the Portfolios after fee
waivers.
 
<TABLE>
<CAPTION>
                                               3       5       10
                                     1 YEAR  YEARS   YEARS    YEARS
                                     ------  ------  ------  -------
<S>                                  <C>     <C>     <C>     <C>
Global Equity Portfolio
  Class A..........................  $  10   $  32   $  55   $  122
  Class B..........................     13      40      69      151
International Equity Portfolio
  Class A..........................     10      32      55      122
  Class B..........................     13      40      69      151
International Small Cap Portfolio
  Class A..........................     32      57      85      163
European Equity Portfolio
  Class A..........................     10      32      55      122
  Class B..........................     13      40      69      151
</TABLE>
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. ACTUAL EXPENSES MAY BE GREATER OR LESS THAN THOSE
SHOWN.
 
                                       4
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following tables provide financial highlights for the Class A and Class
B shares of the Multiclass Portfolios and the Class A shares of the
International Small Cap Portfolio for each of the periods presented. The audited
financial highlights for the Portfolios' shares for each of the periods
presented are part of the Fund's financial statements which appear in the Fund's
December 31, 1996 Annual Report to Shareholders and which are incorporated by
reference into the Fund's Statement of Additional Information. The Portfolios'
financial highlights for each of the periods presented have been audited by
Price Waterhouse LLP, whose unqualified report thereon is also incorporated by
reference into the Statement of Additional Information. Additional performance
information is included in the Annual Report. The Annual Report and the
financial statements therein, along with the Statement of Additional
Information, are available at no cost from the Fund at the address and telephone
number noted on the cover page of this Prospectus. After October 31, 1992, the
Fund changed its fiscal year end to December 31. The following information
should be read in conjunction with financial statements and notes thereto.
 
                                       5
<PAGE>
                            GLOBAL EQUITY PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                   CLASS A                                           CLASS B
                             -----------------------------------------------------------------------------------   ------------
                                                                                                    PERIOD FROM    PERIOD FROM
                                                                                      TWO MONTHS      JULY 15,      JANUARY 2,
                              YEAR ENDED    YEAR ENDED    YEAR ENDED    YEAR ENDED      ENDED         1992* TO      1996*** TO
                             DECEMBER 31,  DECEMBER 31,  DECEMBER 31,  DECEMBER 31,  DECEMBER 31,   OCTOBER 31,    DECEMBER 31,
                                 1996          1995          1994          1993          1992           1992           1996
                             ------------  ------------  ------------  ------------  ------------   ------------   ------------
<S>                          <C>           <C>           <C>           <C>           <C>            <C>            <C>
NET ASSET VALUE, BEGINNING
 OF PERIOD..................   $ 14.31       $ 13.40       $ 13.87       $  9.75       $  9.35        $ 10.00         $14.36
                             ------------  ------------  ------------  ------------  ------------   ------------      ------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Income
   (1)......................      0.23          0.18          0.08          0.08          0.01           0.02           0.13
  Net Realized and
   Unrealized Gain (Loss) on
   Investments..............      3.02          2.26          0.79          4.18          0.39          (0.67)          3.02
                             ------------  ------------  ------------  ------------  ------------   ------------      ------
    Total from Investment
     Operations.............      3.25          2.44          0.87          4.26          0.40          (0.65)          3.15
                             ------------  ------------  ------------  ------------  ------------   ------------      ------
DISTRIBUTIONS
  Net Investment Income.....     (0.23)        (0.22)        (0.12)        (0.02)           --             --          (0.21)
  In Excess of Net
   Investment Income........        --            --            --         (0.03)           --             --             --
  Net Realized Gain.........     (1.09)        (1.31)        (1.22)        (0.09)           --             --          (1.09)
                             ------------  ------------  ------------  ------------  ------------   ------------      ------
    Total Distributions.....     (1.32)        (1.53)        (1.34)        (0.14)           --             --          (1.30)
                             ------------  ------------  ------------  ------------  ------------   ------------      ------
NET ASSET VALUE, END OF
 PERIOD.....................   $ 16.24       $ 14.31       $ 13.40       $ 13.87       $  9.75        $  9.35         $16.21
                             ------------  ------------  ------------  ------------  ------------   ------------      ------
                             ------------  ------------  ------------  ------------  ------------   ------------      ------
TOTAL RETURN................     22.83%        18.66%         6.95%        44.24%         4.28%         (6.50)%        22.04%
                             ------------  ------------  ------------  ------------  ------------   ------------      ------
                             ------------  ------------  ------------  ------------  ------------   ------------      ------
RATIOS AND SUPPLEMENTAL
 DATA:
  Net Assets, End of Period
   (Thousands)..............   $80,297       $91,675       $78,935       $19,918       $11,739        $11,257         $3,928
  Ratio of Expenses to
   Average Net Assets (1)...      1.00%         1.00%         1.00%         1.00%         1.00%**        1.00%**        1.25%**
  Ratio of Net Investment
   Income to Average Net
   Assets (1)...............      1.38%         1.17%         0.87%         0.84%         0.69%**        1.00%**        1.29%**
  Portfolio Turnover Rate...        26%           28%           12%           42%            5%            10%            26%
  Average Commission Rate
   #........................   $0.0299           N/A           N/A           N/A           N/A            N/A        $0.0299
</TABLE>
 
- ------------------------------
 
<TABLE>
<C> <S>                       <C>           <C>           <C>           <C>           <C>            <C>            <C>
(1) Effect of voluntary
     expense limitation
     during the period:
      Per share benefit to
       net investment
       income...............     $0.03         $0.02         $0.02         $0.01         $0.02          $0.08          $0.01
    Ratios before expense
     limitation:
      Expenses to Average
       Net Assets...........      1.15%         1.13%         1.24%         1.66%         2.49%**        5.22%**        1.39%**
      Net Investment Income
       (Loss) to Average Net
       Assets...............      1.23%         1.04%         0.63%         0.18%        (0.80)%**      (3.22)%**       1.15%**
</TABLE>
 
  * Commencement of operations.
 
 ** Annualized
 
*** The Portfolio began offering Class B Shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period. For the year ended December 31,
   1996, the average commission rate paid on trades on which commissions were
   charged was 0.25% of the trade amount.
 
                                       6
<PAGE>
                         INTERNATIONAL EQUITY PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                                                                    CLASS B
                                                                   CLASS A                                        ------------
                             -----------------------------------------------------------------------------------  PERIOD FROM
                                                                                      TWO MONTHS                   JANUARY 2,
                              YEAR ENDED    YEAR ENDED    YEAR ENDED    YEAR ENDED      ENDED        YEAR ENDED    1996*** TO
                             DECEMBER 31,  DECEMBER 31,  DECEMBER 31,  DECEMBER 31,  DECEMBER 31,   OCTOBER 31,   DECEMBER 31,
                                 1996          1995          1994          1993          1992           1992          1996
                             ------------  ------------  ------------  ------------  ------------   ------------  ------------
<S>                          <C>           <C>           <C>           <C>           <C>            <C>           <C>
NET ASSET VALUE, BEGINNING
 OF PERIOD..................  $    15.15    $    15.34    $    14.09     $   9.98      $   9.83       $  10.52       $15.24
                             ------------  ------------  ------------  ------------  ------------   ------------     ------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Income
   (1)......................        0.25          0.16          0.16         0.15          0.01           0.12         0.23
  Net Realized and
   Unrealized Gain (Loss) on
   Investments..............        2.71          1.55          1.54         4.36          0.14          (0.59)        2.59
                             ------------  ------------  ------------  ------------  ------------   ------------     ------
    Total from Investment
     Operations.............        2.96          1.71          1.70         4.51          0.15          (0.47)        2.82
                             ------------  ------------  ------------  ------------  ------------   ------------     ------
DISTRIBUTIONS
  Net Investment Income.....       (0.36)        (0.06)        (0.18)       (0.01)           --          (0.17)       (0.33)
  In Excess of Net
   Investment Income........          --            --            --        (0.13)           --             --           --
  Net Realized Gain.........       (0.80)        (1.84)        (0.27)       (0.26)           --          (0.05)       (0.80)
                             ------------  ------------  ------------  ------------  ------------   ------------     ------
    Total Distributions.....       (1.16)        (1.90)        (0.45)       (0.40)           --          (0.22)       (1.13)
                             ------------  ------------  ------------  ------------  ------------   ------------     ------
NET ASSET VALUE, END OF
 PERIOD.....................  $    16.95    $    15.15    $    15.34     $  14.09      $   9.98       $   9.83       $16.93
                             ------------  ------------  ------------  ------------  ------------   ------------     ------
                             ------------  ------------  ------------  ------------  ------------   ------------     ------
TOTAL RETURN................       19.64%        11.77%        12.39%       46.50%         1.53%         (4.56)%      18.58%
                             ------------  ------------  ------------  ------------  ------------   ------------     ------
                             ------------  ------------  ------------  ------------  ------------   ------------     ------
RATIOS AND SUPPLEMENTAL
 DATA:
  Net Assets, End of Period
   (Thousands)..............  $2,264,424    $1,598,530    $1,304,770     $947,045      $510,727       $486,836       $5,393
  Ratio of Expenses to
   Average Net
   Assets (1)...............        1.00%         1.00%         1.00%        1.00%         1.00%**        1.00%        1.25%**
  Ratio of Net Investment
   Income to Average Net
   Assets (1)...............        1.64%         1.38%         1.12%        1.25%         0.68%**        1.46%        1.68%**
  Portfolio Turnover Rate...          18%           27%           16%          23%            5%            12%          18%
  Average Commission
   Rate#....................     $0.0238           N/A           N/A          N/A           N/A            N/A      $0.0238
</TABLE>
 
- ------------------------
 
<TABLE>
<C> <S>                         <C>           <C>           <C>          <C>           <C>            <C>          <C>
(1) Effect of voluntary
     expense limitation
     during the period:
      Per share benefit to
       net investment
       income...............       $0.00        $0.003        $0.004        $0.01         $0.00          $0.00        $0.00
    Ratios before expense
     limitation:
      Expenses to Average
       Net Assets...........        1.02%         1.03%         1.03%        1.06%         1.14%**        1.02%        1.27%**
      Net Investment Income
       to Average Net
       Assets...............        1.61%         1.35%         1.09%        1.19%         0.54%**        1.44%        1.66%**
</TABLE>
 
 ** Annualized
 
*** The Portfolio began offering Class B Shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period. For the year ended December 31,
   1996, the average commission rate paid on trades on which commissions were
   charged was 0.26% of the trade amount.
 
                                       7
<PAGE>
                       INTERNATIONAL SMALL CAP PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                                                               PERIOD FROM
                                                                                                              DECEMBER 15,
                                               YEAR ENDED      YEAR ENDED      YEAR ENDED      YEAR ENDED       1992* TO
                                              DECEMBER 31,    DECEMBER 31,    DECEMBER 31,    DECEMBER 31,    DECEMBER 31,
                                                  1996            1995            1994           1993++           1992
                                              -------------   -------------   -------------   -------------   -------------
<S>                                           <C>             <C>             <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD........  $   14.94       $   15.15       $   14.64       $   10.09       $   10.00
                                              -------------   -------------   -------------   -------------      ------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1).................       0.21            0.24            0.14            0.09            0.01
  Net Realized and Unrealized Gain on
   Investments (2)..........................       2.29            0.15            0.62            4.48            0.08
                                              -------------   -------------   -------------   -------------      ------
    Total from Investment Operations........       2.50            0.39            0.76            4.57            0.09
                                              -------------   -------------   -------------   -------------      ------
DISTRIBUTIONS
  Net Investment Income.....................      (0.22)          (0.23)          (0.03)           0.00              --
  In Excess of Net Investment Income........         --              --              --           (0.02)             --
  Net Realized Gain.........................      (0.39)          (0.37)          (0.22)             --              --
                                              -------------   -------------   -------------   -------------      ------
    Total Distributions.....................      (0.61)          (0.60)          (0.25)          (0.02)             --
                                              -------------   -------------   -------------   -------------      ------
NET ASSET VALUE, END OF PERIOD                $   16.83       $   14.94       $   15.15       $   14.64       $   10.09
                                              -------------   -------------   -------------   -------------      ------
                                              -------------   -------------   -------------   -------------      ------
TOTAL RETURN................................      16.82%           2.60%           5.25%          45.34%           0.90%
                                              -------------   -------------   -------------   -------------      ------
                                              -------------   -------------   -------------   -------------      ------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands).....  $ 234,743       $ 198,669       $ 160,101       $  52,834       $   3,824
  Ratio of Expenses to Average Net Assets
   (1)......................................       1.15%           1.15%           1.15%           1.15%           1.15%**
  Ratio of Net Investment Income to
   Average Net Assets (1)...................       1.29%           1.72%           1.18%           0.66%           1.37%**
  Portfolio Turnover Rate...................         35%             24%              8%             14%              0%
  Average Commission Rate#..................    $0.0159             N/A             N/A             N/A             N/A
</TABLE>
 
- ------------------------------
 
<TABLE>
<C> <S>                                        <C>             <C>             <C>             <C>             <C>
(1) Effect of voluntary expense limitation
     during the period:
      Per share benefit to net investment
       income...............................      $0.01           $0.01           $0.02           $0.10           $0.16
    Ratios before expense limitation:
      Expenses to Average Net Assets........       1.23%           1.24%           1.29%           1.86%          21.67%**
      Net Investment Income/(Loss) to
       Average Net Assets...................       1.20%           1.63%           1.04%          (0.05)%        (19.15)%**
(2) Reflects a 1% transaction fee on
     purchases and redemptions of capital
     shares.
</TABLE>
 
 * Commencement of operations.
 
** Annualized
 
++ Per share amounts for the year ended December 31, 1993 are based on average
   outstanding shares.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period. For the year ended December 31,
   1996, the average commission rate paid on trades on which commissions were
   charged was 0.30% of the trade amount.
 
                                       8
<PAGE>
                           EUROPEAN EQUITY PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                          CLASS A                                 CLASS B
                                               -------------------------------------------------------------   -------------
                                                                                                PERIOD FROM     PERIOD FROM
                                                                                                 APRIL 2,       JANUARY 2,
                                                YEAR ENDED      YEAR ENDED      YEAR ENDED       1993* TO       1996*** TO
                                               DECEMBER 31,    DECEMBER 31,    DECEMBER 31,    DECEMBER 31,    DECEMBER 31,
                                                   1996            1995            1994            1993            1996
                                               -------------   -------------   -------------   -------------   -------------
<S>                                            <C>             <C>             <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........  $   13.92       $   13.94       $   12.91       $   10.00       $   14.05
                                               -------------   -------------   -------------   -------------      ------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)..................       0.24            0.14            0.08            0.08            0.18
  Net Realized and Unrealized Gain on
   Investments...............................       2.85            1.37            1.29            2.83            2.73
                                               -------------   -------------   -------------   -------------      ------
    Total from Investment Operations.........       3.09            1.51            1.37            2.91            2.91
                                               -------------   -------------   -------------   -------------      ------
DISTRIBUTIONS
  Net Investment Income......................      (0.25)          (0.15)          (0.09)             --           (0.23)
  In Excess of Net Investment Income.........      (0.02)             --              --              --           (0.02)
  Net Realized Gain..........................      (0.04)          (1.38)          (0.25)             --           (0.04)
                                               -------------   -------------   -------------   -------------      ------
    Total Distributions......................      (0.31)          (1.53)          (0.34)             --           (0.29)
                                               -------------   -------------   -------------   -------------      ------
NET ASSET VALUE, END OF PERIOD...............  $   16.70       $   13.92       $   13.94       $   12.91       $   16.67
                                               -------------   -------------   -------------   -------------      ------
                                               -------------   -------------   -------------   -------------      ------
TOTAL RETURN.................................      22.29%          11.85%          10.88%          29.10%          20.76%
                                               -------------   -------------   -------------   -------------      ------
                                               -------------   -------------   -------------   -------------      ------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)......  $ 178,356       $  69,583       $  27,634       $  12,681          $2,654
  Ratio of Expenses to Average Net Assets
   (1).......................................       1.00%           1.00%           1.00%           1.00%**         1.25%**
  Ratio of Net Investment Income to Average
   Net Assets (1)............................       1.83%           1.37%           0.87%           1.23%**         1.67%**
  Portfolio Turnover Rate....................         24%             13%             79%             15%             24%
  Average Commission Rate#...................    $0.0212             N/A             N/A             N/A         $0.0212
</TABLE>
 
- --------------------------
 
<TABLE>
<C> <S>                                         <C>             <C>             <C>             <C>             <C>
(1) Effect of voluntary expense limitation
     during the period:
      Per share benefit to net investment
       income................................      $0.02           $0.03           $0.06           $0.09           $0.02
    Ratios before expense limitation:
      Expenses to Average Net Assets.........       1.16%           1.25%           1.62%           2.43%**         1.40%**
      Net Investment Income (Loss) to Average
       Net Assets............................       1.67%           1.12%           0.25%          (0.21)%**        1.52%**
</TABLE>
 
  * Commencement of operations.
 
 ** Annualized
 
*** The Portfolio began offering Class B Shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period. For the year ended December 31,
   1996, the average commission rate paid on trades on which commissions were
   charged was 0.23% of the trade amount.
 
                                       9
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and high net worth individual investors a broad range of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates providing customized services as Adviser, Administrator and
Distributor. Each portfolio offers Class A shares and, except for the
International Small Cap, Money Market and Municipal Money Market Portfolios,
also offers Class B shares. Each portfolio has its own investment objective and
policies designed to meet its specific goals. The investment objective of each
Portfolio described in this Prospectus is as follows:
 
    -The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers throughout the world,
     including U.S. issuers.
 
    -The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers.
 
    -The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
     by investing primarily in equity securities of non-U.S. issuers with equity
     market capitalizations of less than $1 billion.
 
    -The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of European issuers.
 
    The other portfolios of the Fund are described in other prospectuses which
may be obtained from the Fund at the address and phone number noted on the cover
page of this Prospectus. The investment objectives of these other portfolios are
listed below:
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    -The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
     appreciation by investing in accordance with country weightings determined
     by the Adviser in equity securities of non-U.S. issuers which, in the
     aggregate, replicate broad country indices.
 
    -The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
     appreciation by investing primarily in equity securities of companies in
     the Asian real estate industry.
 
    -The CHINA GROWTH PORTFOLIO seeks to provide long-term capital appreciation
     by investing primarily in equity securities of issuers in The People's
     Republic of China, Hong Kong and Taiwan.
 
    -The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of emerging country issuers.
 
    -The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income and
     long-term capital appreciation by investing primarily in equity securities
     of companies in the European real estate industry.
 
    -The GOLD PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of foreign and domestic issuers engaged in
     gold-related activities.
 
    -The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers domiciled in
     EAFE countries.
 
                                       10
<PAGE>
 
    -The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Japanese issuers.
 
    -The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Latin American issuers and,
     from time to time, debt securities issued or guaranteed by Latin American
     governments or governmental entities.
 
    U.S. EQUITY:
 
    -The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by investing
     primarily in corporate equity and equity-linked securities.
 
    -The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing primarily in growth-oriented equity securities of small- to
     medium-sized corporations.
 
    -The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing in growth-oriented equity securities of medium and large
     capitalization companies.
 
    -The MICROCAP PORTFOLIO seeks long-term capital appreciation by investing
     primarily in growth-oriented equity securities of small corporations.
 
    -The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total return by
     investing in undervalued equity securities of small- to medium-sized
     companies.
 
    -The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of companies that, in the opinion of the
     Portfolio's investment adviser, are expected to benefit from their
     involvement in technology and technology-related industries.
 
    -The U.S. EQUITY PLUS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers included in the S&P 500
     Index ("S&P 500").
 
    -The U.S. REAL ESTATE PORTFOLIO seeks to provide above average current
     income and long-term capital appreciation by investing primarily in equity
     securities of companies in the U.S. real estate industry, including real
     estate investment trusts.
 
    -The VALUE EQUITY PORTFOLIO seeks high total return by investing in equity
     securities which the Adviser believes to be undervalued relative to the
     stock market in general at the time of purchase.
 
    EQUITY AND FIXED INCOME:
 
    -The BALANCED PORTFOLIO seeks high total return while preserving capital by
     investing in a combination of undervalued equity securities and fixed
     income securities.
 
    FIXED INCOME:
 
    -The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by investing
     primarily in debt securities of government, government-related and
     corporate issuers located in emerging countries.
 
    -The FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
     with the preservation of capital by investing in a diversified portfolio of
     fixed income securities.
 
    -The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
     of return while preserving capital by investing in fixed income securities
     of issuers throughout the world, including U.S. issuers.
 
                                       11
<PAGE>
    -The HIGH YIELD PORTFOLIO seeks to maximize total return by investing in a
     diversified portfolio of high yield fixed income securities that offer a
     yield above that generally available on debt securities in the four highest
     rating categories of the recognized rating services.
 
    -The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a level
     of current income as is consistent with the preservation of capital by
     investing primarily in a variety of investment-grade mortgage-backed
     securities.
 
    -The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of current
     income consistent with preservation of principal by investing primarily in
     municipal obligations, the interest on which is exempt from federal income
     tax.
 
    MONEY MARKET:
 
    -The MONEY MARKET PORTFOLIO seeks to maximize current income and preserve
     capital while maintaining high levels of liquidity through investing in
     high-quality money market instruments with remaining maturities of one year
     or less.
 
    -
    The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current tax-exempt
    income and preserve capital while maintaining high levels of liquidity
    through investing in high-quality money market instruments with remaining
    maturities of one year or less which are exempt from federal income tax.
 
    THE CHINA GROWTH, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS ARE
    CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley, Dean Witter, Discover & Co., acts as investment adviser to the Fund and
each of its portfolios. As of August 31, 1997, Morgan Stanley Asset Management
Inc. and its affiliated asset management companies (exclusive of Miller Anderson
& Sherrerd, LLP, Van Kampen American Capital, Inc. and Dean Witter InterCapital
Inc.) managed assets of approximately $80.9 billion. See "Management of the
Fund--Investment Adviser" and "Management of the Fund--Administrator."
 
HOW TO INVEST
 
    Class A shares of each Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of each
Multiclass Portfolio are offered at net asset value with no sales commission,
but with a 12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25%
of the Class B shares' average daily net assets on an annualized basis.
Shareholders of the International Small Cap Portfolio may be charged a 1.00%
transaction fee, which is payable directly to the International Small Cap
Portfolio, in connection with each purchase and redemption of shares of the
Portfolio. Share purchases may be made by sending investments directly to the
Fund or through the Distributor. The minimum initial investment, generally, is
$500,000 for Class A shares of each Portfolio and $100,000 for Class B shares of
each Multiclass Portfolio. The minimum initial investment amount is reduced for
certain categories of investors. For additional information on how to purchase
shares and minimum initial investments, see "Purchase of Shares."
 
                                       12
<PAGE>
HOW TO REDEEM
 
    Shares of each Portfolio may be redeemed at any time, without cost, at the
net asset value per share of shares of the applicable class next determined
after receipt of the redemption request, (except that shareholders of the
International Small Cap Portfolio may be charged a 1.00% transaction fee, which
is payable directly to the International Small Cap Portfolio, in connection with
each purchase and redemption of shares of the Portfolio). The redemption price
may be more or less than the purchase price. Certain redemptions that cause the
value of an account to remain for a continuous 60-day period below the minimum
investment amount for Class A shares or for Class B shares may result in
involuntary redemption or automatic conversion. For additional information on
how to redeem shares and involuntary redemption or conversion, see "Purchase of
Shares -- Minimum Account Sizes and Involuntary Redemption of Shares" and
"Redemption of Shares."
 
RISK FACTORS
 
    The investment policies of each of the Portfolios entail certain risks and
considerations of which an investor should be aware. Each Portfolio will invest
in securities of foreign issuers, which are subject to certain risks not
typically associated with domestic securities. Each Portfolio may invest in
securities of issuers located in emerging markets. These securities may pose
greater liquidity risks and other risks not typically associated with investing
in more established markets. In addition, each Portfolio may invest in
repurchase agreements, lend its portfolio securities, purchase securities on a
when-issued or delayed delivery basis and invest in foreign currency forward
contracts. The International Small Cap Portfolio may invest in securities that
are neither listed on a stock exchange nor traded over-the-counter, including
private placement securities. The Global Equity Portfolio may also invest
indirectly in securities through sponsored or unsponsored Depositary Receipts.
Each of these investment strategies involves specific risks which are described
under "Investment Objectives and Policies" and "Additional Investment
Information" herein and under "Investment Objectives and Policies" in the
Statement of Additional Information.
 
                                       13
<PAGE>
                       INVESTMENT OBJECTIVES AND POLICIES
 
    The investment objective of each Portfolio is described below, together with
the policies the Portfolios employ in their efforts to achieve these objectives.
Each Portfolio's investment objective is a fundamental policy which may not be
changed without the approval of a majority of the Portfolio's outstanding voting
securities. There is no assurance that the Portfolios will attain their
objectives. Each of the Portfolios invests in equity securities, which include
common and preferred stocks, convertible securities and rights and warrants to
purchase common stocks. In addition to the investments and strategies described
below, the Portfolios may invest in certain securities and obligations as set
forth in "Additional Investment Information" below. The investment policies
described below are not fundamental policies and may be changed without
shareholder approval.
 
THE GLOBAL EQUITY PORTFOLIO
 
    The Global Equity Portfolio seeks long-term capital appreciation by
investing primarily in equity securities of issuers throughout the world,
including U.S. issuers. At least 65% of the total assets of the Portfolio will
be invested in equity securities under normal circumstances. The Adviser expects
that, under normal circumstances, at least 20% of the Portfolio's total assets
will be invested in the common stocks of U.S. issuers. The remainder of the
Portfolio will be invested in issuers located throughout the world, including
those located in emerging markets. Securities of issuers located in emerging
markets may not be as liquid as those in developed markets and pose greater
risks. Although the Portfolio intends to invest primarily in securities listed
on stock exchanges, it will also invest in securities traded in over-the-counter
markets and may invest in equity securities in the form of Depositary Receipts.
 
    The Adviser's approach in selecting investments for the Portfolio is
oriented to individual stock selection, and is value driven. In selecting stocks
for the Portfolio, the Adviser initially identifies those stocks which it
believes to be undervalued in relation to the issuer's assets, cash flow,
earnings and revenues, and then evaluates the future value of such stocks by
running the results of an in-depth study of the issuer through a dividend
discount model. The Adviser utilizes the research of a number of sources,
including Morgan Stanley Capital International, an affiliate of the Adviser
located in Geneva, Switzerland, in identifying attractive securities, and
applies a number of proprietary screening criteria to identify those securities
it believes to be undervalued. Portfolio holdings are regularly reviewed and
subjected to fundamental analysis to determine whether they continue to conform
to the Adviser's value criteria. Securities which no longer conform to such
value criteria are sold.
 
THE INTERNATIONAL EQUITY PORTFOLIO
 
    The investment objective of the International Equity Portfolio is to provide
long-term capital appreciation. The production of any current income is
incidental to this objective. The Portfolio seeks to achieve its objective by
investing primarily in equity securities of non-U.S. issuers. At least 65% of
the total assets of the Portfolio will be invested in such equity securities
under normal circumstances.
 
    The Adviser's orientation to individual stock selection and value driven
approach in selecting investments for the Portfolio are the same as those
described for the Global Equity Portfolio discussed above. While the Portfolio
is not subject to any specific geographic diversification requirements, it
currently intends to diversify investments among countries to reduce risk,
including currency risk. Investments will be made primarily in equity securities
of companies domiciled in developed countries, but may also be made in equity
securities of
 
                                       14
<PAGE>
issuers domiciled in emerging markets. The Portfolio will not, under normal
circumstances, invest in equity securities of U.S. issuers. Although the
Portfolio intends to invest primarily in equity securities listed on stock
exchanges, it will also invest in equity securities traded in over-the-counter
markets. Securities of companies in emerging countries may pose liquidity risks.
For a description of special considerations and certain risks associated with
investments in foreign issuers, see "Additional Investment Information."
 
THE INTERNATIONAL SMALL CAP PORTFOLIO
 
    The investment objective of the International Small Cap Portfolio is to
provide long-term capital appreciation. The production of any current income is
incidental to this objective. The Portfolio seeks to achieve its objective by
investing primarily in equity securities of non-U.S. issuers with equity market
capitalizations of less than $1 billion. At least 65% of the total assets of the
Portfolio will be invested in such equity securities under normal circumstances.
The Portfolio will invest a minimum of 80% of its total assets in companies with
market capitalizations of less than $1 billion. The Adviser's orientation to
individual stock selection and value driven approach in selecting investments
for the Portfolio are the same as those described for the Global Equity
Portfolio discussed above.
 
    While the Portfolio is not subject to any specific geographic
diversification requirements, it currently intends to diversify investments
among countries to reduce risk, including currency risk. Investments will be
made primarily in equity securities of companies domiciled in developed
countries. Limited investments may also be made in the securities of companies
domiciled in emerging countries, but will not normally exceed 5% of the total
assets of the Portfolio. Although the Portfolio intends to invest primarily in
equity securities listed on stock exchanges, it may also invest in equity
securities traded in over-the-counter markets and in privately placed
securities. Small capitalization securities involve greater issuer risk and the
markets for such securities may be more volatile and less liquid. Securities of
companies in emerging countries may pose liquidity risks. The Portfolio will
not, under normal circumstances, invest in equity securities of U.S. issuers.
For a description of special considerations and certain risks associated with
investments in foreign issuers, see "Additional Investment Information."
 
THE EUROPEAN EQUITY PORTFOLIO
 
    The investment objective of the European Equity Portfolio is to provide
long-term capital appreciation. The Portfolio seeks to achieve this objective by
investing primarily in equity securities of European issuers, including those
located in Germany, France, Switzerland, Belgium, Italy, Finland, Sweden,
Denmark, Norway and the United Kingdom. Investments may also be made in equity
securities of issuers located in the smaller and emerging markets of Europe.
 
    While the Portfolio is not subject to any specific geographic
diversification requirements, it currently intends to diversify investments
among countries to reduce currency risk. At least 65% of the total assets of the
Portfolio will be invested in equity securities of European issuers under normal
circumstances. The Portfolio will not, under normal circumstances, invest in
equity securities of U.S. issuers. The Adviser's orientation to individual stock
selection and value-driven approach in selecting investments for the Portfolio
are the same as those described for the Global Equity Portfolio discussed above.
Securities in emerging markets may not be as liquid as those in developed
markets and pose greater risks. Although the Portfolio intends to invest
primarily in
 
                                       15
<PAGE>
equity securities listed on stock exchanges, it will also invest in equity
securities traded in over-the-counter markets. For a description of special
considerations and certain risks associated with investments in foreign issuers,
see "Additional Investment Information."
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    DEPOSITARY RECEIPTS.  The Global Equity Portfolio may invest in Depositary
Receipts, including American Depositary Receipts ("ADRs"), Global Depositary
Receipts ("GDRs"), European Depositary Receipts ("EDRs") and other Depositary
Receipts (which, together with ADRs, GDRs and EDRs, are hereinafter collectively
referred to as "Depositary Receipts"), to the extent that such Depositary
Receipts are or become available. ADRs are securities, typically issued by a
U.S. financial institution (a "depositary"), that evidence ownership interests
in a security or a pool of securities issued by a foreign issuer (the
"underlying issuer") and deposited with the depositary. ADRs include American
Depositary Shares and New York Shares and may be "sponsored" or "unsponsored."
Sponsored ADRs are established jointly by a depositary and the underlying
issuer, whereas unsponsored ADRs may be established by a depositary without
participation by the underlying issuer. The issuers of the stock of unsponsored
ADRs are not obligated to disclose material information in the United States and
therefore, there may not be a correlation between such information and the
market value of the ADR. GDRs, EDRs and other types of Depositary Receipts are
typically issued by foreign depositaries, although they may also be issued by
U.S. depositaries, and evidence ownership interests in a security or pool of
securities issued by either a foreign or a U.S. corporation. Generally,
Depositary Receipts in registered form are designed for use in the U.S.
securities market and Depositary Receipts in bearer form are designed for use in
securities markets outside the United States. The Portfolio may invest in
sponsored and unsponsored Depositary Receipts. For purposes of the Portfolio's
investment policies, the Portfolio's investments in Depositary Receipts will be
deemed to be investments in the underlying securities.
 
    FOREIGN CURRENCY FORWARD CONTRACTS.  Each Portfolio may enter into foreign
currency forward contracts ("forward contracts") that provide for the purchase
or sale of an amount of a specified currency at a future date. The Portfolios
may use such contracts to protect against a decline in a foreign currency
against the U.S. dollar between the trade date and settlement date when the
Portfolio purchases or sells securities, lock in the U.S. dollar value of
dividends and interest on securities held by the Portfolio, and generally to
protect the U.S. dollar value of securities held by the Portfolio against
exchange rate fluctuation. While forward contracts may limit losses as a result
of exchange rate fluctuations, they will also limit any gains that might
otherwise have been realized. The Portfolio's Custodian may be required to place
cash or liquid securities in a segregated account in an amount equal to the
value of the Portfolio's total assets committed to the consummation of forward
contracts. If the value of the securities placed in the segregated account
declines, additional cash or securities will be placed in the account on a daily
basis so that the value of the account will be at least equal to the amount of
the Portfolio's commitments with respect to such contracts.
 
    FOREIGN INVESTMENT.  Investment in securities of foreign issuers involves
somewhat different investment risks than those affecting securities of U.S.
domestic issuers. There may be limited publicly available information with
respect to foreign issuers, and foreign issuers are not generally subject to
uniform accounting, auditing and financial and other reporting standards and
requirements comparable to those applicable to U.S. companies. There may also be
less government supervision and regulation of foreign securities exchanges,
brokers and listed companies than in the United States. Many foreign securities
markets have substantially less volume than U.S.
 
                                       16
<PAGE>
national securities exchanges, and securities of some foreign issuers are less
liquid and more volatile than securities of comparable domestic issuers.
Brokerage commissions and other transaction costs on foreign securities
exchanges are generally higher than in the United States. Dividends and interest
paid by foreign issuers may be subject to withholding and other foreign taxes,
which may decrease the net return on foreign investments as compared to
dividends and interest paid to the Portfolios by domestic companies, and it is
not expected that a Portfolio or its shareholders would be able to claim a
credit for U.S. tax purposes with respect to any such foreign taxes. Additional
risks include future political and economic developments, the possibility that a
foreign jurisdiction might impose or change withholding taxes on income payable
with respect to foreign securities, possible seizure, nationalization or
expropriation of the foreign issuer or foreign deposits and the possible
adoption of foreign governmental restrictions such as exchange controls. Many of
the emerging countries may have less stable political environments than more
developed countries. Also, it may be more difficult to obtain a judgment in a
court outside the United States.
 
    Investments in securities of foreign issuers are frequently denominated in
foreign currencies, and the Portfolios may temporarily hold uninvested reserves
in bank deposits in foreign currencies. Therefore, the value of each Portfolio's
assets as measured in U.S. dollars may be affected favorably or unfavorably by
changes in currency rates and in exchange control regulations, and the
Portfolios may incur costs in connection with conversions between various
currencies.
 
    LOANS OF PORTFOLIO SECURITIES.  Each Portfolio may lend its securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing its net investment income. These loans must be secured
continuously by cash or equivalent collateral or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be risks of delay in recovery of the securities or even loss
of rights in the collateral should the borrower of the securities fail
financially. A Portfolio will not enter into securities loan transactions
exceeding in the aggregate 33 1/3% of the market value of the Portfolio's total
assets.
 
    MONEY MARKET INSTRUMENTS.  The Portfolios are permitted to invest in money
market instruments, although each Portfolio intends to stay invested in
securities satisfying its primary investment objective to the extent practical.
Consistent with their investment policies, each Portfolio may make money market
investments pending other investment or settlement for liquidity. In addition,
the Portfolios may invest in money market instruments for temporary defensive
purposes during adverse market conditions. See "Temporary Investments." The
money market investments permitted for the Portfolios include obligations of the
U.S. Government and its agencies and instrumentalities; obligations of foreign
sovereignties; other debt securities; commercial paper; bank obligations;
certificates of deposit (including Eurodollar certificates of deposit); and
repurchase agreements.
 
    NON-PUBLICLY TRADED SECURITIES, PRIVATE PLACEMENTS AND RESTRICTED
SECURITIES.  The International Small Cap Portfolio may invest in securities that
are neither listed on a stock exchange nor traded over-the-counter, including
privately placed securities. Such unlisted equity securities may involve a
higher degree of business and financial risk that can result in substantial
losses. As a result of the absence of a public trading market for these
securities, they may be less liquid than publicly traded securities. Although
these securities may be resold in privately negotiated transactions, the prices
realized from these sales could be less than those originally paid by the
Portfolio or less than what may be considered the fair value of such securities.
Further, companies whose securities are not publicly traded may not be subject
to the disclosure and other investor
 
                                       17
<PAGE>
protection requirements which might be applicable if their securities were
publicly traded. If such securities are required to be registered under the
securities laws of one or more jurisdictions before being resold, the Portfolio
may be required to bear the expenses of registration.
 
    As a general matter, the Portfolio may not invest more than 15% of its net
assets in illiquid securities, including securities for which there is no
readily available secondary market. Nor as a general matter, may the Portfolio
invest more than 10% of its total assets in securities that are restricted from
sale to the public without registration ("Restricted Securities") under the
Securities Act of 1933, as amended (the "1933 Act"). However, the Portfolio may
invest up to 25% of its total assets in liquid Restricted Securities that can be
offered and sold to qualified institutional buyers under Rule 144A under the
1933 Act ("Rule 144A Securities"). The Board of Directors has adopted guidelines
and delegated to the Adviser, subject to the supervision of the Board of
Directors, the daily function of determining and monitoring the liquidity of
Rule 144A Securities. Rule 144A Securities may become illiquid if qualified
institutional buyers are not interested in acquiring the securities.
 
    REPURCHASE AGREEMENTS.  Each Portfolio may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines established by
the Fund's Board of Directors. In a repurchase agreement, the Portfolio buys a
security from a seller that has agreed to repurchase it at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of the
agreement. The term of these agreements is usually from overnight to one week
and never exceeds one year. Repurchase agreements may be viewed as a fully
collateralized loan of money by the Portfolio to the seller. The Portfolio
always receives securities with a market value at least equal to the purchase
price (including accrued interest) as collateral, and this value is maintained
during the term of the agreement. If the seller defaults and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with respect to the seller, the Portfolio's realization upon the
collateral may be delayed or limited. The Portfolio may not enter into
repurchase agreements with more than seven days to maturity if, as a result,
more than 15% of the market value of the Portfolio's net assets are invested in
these agreements and other investments for which market quotations are not
readily available or which are otherwise illiquid.
 
    TEMPORARY INVESTMENTS.  For temporary defensive purposes, when the Adviser
determines that market conditions warrant, each Portfolio may invest up to 100%
of its assets in dollar and non-dollar denominated money market instruments and
short- and medium-term debt securities that the Adviser believes to be of high
quality, or hold cash. The short- and medium-term debt securities in which a
Portfolio may invest consist of (a) obligations of the U.S. or foreign country
governments, their respective agencies or instrumentalities; (b) bank deposits
and bank obligations (including certificates of deposit, time deposits and
bankers' acceptances) of U.S. or foreign country banks denominated in any
currency; (c) floating rate securities and other instruments denominated in any
currency issued by international development agencies; (d) finance company and
corporate commercial paper and other short-term corporate debt obligations of
U.S. and foreign country corporations meeting the Portfolio's credit quality
standards; and (e) repurchase agreements with banks and broker-dealers with
respect to such securities.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  Each Portfolio may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Delivery of and payment for these securities may take
as long as a month or more after the date of the purchase commitment but will
take place no more than 120 days after the trade date. Each Portfolio will
 
                                       18
<PAGE>
maintain with the Custodian a separate account with a segregated portfolio of
cash or liquid securities in an amount at least equal to these commitments. The
payment obligation and the interest rates that will be received are each fixed
at the time a Portfolio enters into the commitment and no interest accrues to
the Portfolio until settlement. Thus, it is possible that the market value at
the time of settlement could be higher or lower than the purchase price if,
among other factors, the general level of interest rates has changed. It is a
current policy of each Portfolio not to enter into when-issued commitments or
delayed delivery securities exceeding in the aggregate 15% of the market value
of the Portfolio's total assets less liabilities, other than the obligations
created by these commitments.
 
                             INVESTMENT LIMITATIONS
 
    Each Portfolio is a diversified investment company under the Investment
Company Act of 1940, as amended (the"1940 Act") and is therefore subject to the
following limitations: (a) as to 75% of its total assets, a Portfolio may not
invest more than 5% of its total assets in the securities of any one issuer,
except obligations of the U.S. Government and its agencies and
instrumentalities, and (b) a Portfolio may not own more than 10% of the
outstanding voting securities of any one issuer.
 
    Each Portfolio also operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of the
holders of a majority of such Portfolio's outstanding shares and under certain
non-fundamental investment limitations that may be changed without shareholder
approval. For additional information on fundamental and non-fundamental
investment limitations, see "Investment Limitations" in the Statement of
Additional Information.
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and each Portfolio. The Adviser provides investment
advice and portfolio management services, pursuant to an Investment Advisory
Agreement and, subject to the supervision of the Fund's Board of Directors,
makes each of the Portfolio's day-to-day investment decisions, arranges for the
execution of portfolio transactions and generally manages each of the
Portfolio's investments. Set forth below as an annual percentage of average
daily net assets are the management fees payable to the Adviser quarterly by
each Portfolio pursuant to the terms of the Investment Advisory Agreement. The
Adviser has agreed to a reduction in the fees payable to it and to reimburse the
Portfolios, if necessary, if such fees would cause total annual operating
expenses of the Portfolios to exceed the maximums set forth in the table below.
 
<TABLE>
<CAPTION>
                                                                    MAXIMUM TOTAL ANNUAL
                                                                         OPERATING
                                                                 EXPENSES AFTER FEE WAIVERS
                                                                 --------------------------
                                              MANAGEMENT FEES
PORTFOLIO                                   ABSENT FEE WAIVERS     CLASS A       CLASS B
- ------------------------------------------  -------------------  ------------  ------------
<S>                                         <C>                  <C>           <C>
Global Equity                                        0.80%             1.00%         1.25%
International Equity                                 0.80%             1.00%         1.25%
International Small Cap                              0.95%             1.15%       N/A
European Equity                                      0.80%             1.00%         1.25%
</TABLE>
 
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to
 
                                       19
<PAGE>
customers in the United States and abroad. The Adviser and Morgan Stanley are
subsidiaries of Morgan Stanley, Dean Witter, Discover & Co. At August 31, 1997,
the Adviser (exclusive of Miller Anderson & Sherrerd, LLP, Van Kampen American
Capital, Inc. and Dean Witter InterCapital Inc.) managed assets of approximately
$80.9 billion. See "Management of the Fund" in the Statement of Additional
Information.
 
    PORTFOLIO MANAGERS.  The following individuals have primary portfolio
management responsibility for the Portfolios noted below:
 
    GLOBAL EQUITY PORTFOLIO -- FRANCES CAMPION.  Frances Campion joined the
Adviser in January 1990 as a Global Equity Fund Manager and is now a Principal
of Morgan Stanley. Her responsibilities include day to day management of the
Global Equity product. Prior to joining the Adviser, Ms. Campion was a U.S.
equity analyst with Lombard Odier Limited where she had responsibility for the
management of global portfolios. Ms. Campion has ten years global investment
experience. She is a graduate of University College, Dublin.
 
    INTERNATIONAL EQUITY PORTFOLIO -- DOMINIC CALDECOTT.  Dominic Caldecott is a
Managing Director and is responsible for research and stock selection in the
Pacific Basin and has been primarily responsible for managing the Portfolio's
assets since its inception. He has ten years professional experience, primarily
in Tokyo, Hong Kong, and Seoul. Prior to joining Morgan Stanley, he worked with
GT Management Group in Tokyo and Hong Kong, specializing in Pacific Basin
investment management. He became a Vice President of Morgan Stanley in 1987, a
Principal in 1989, and a Managing Director in 1991. He is responsible for a
number of Pacific Basin investment programs for clients of Morgan Stanley. Mr.
Caldecott is a graduate of New College, Oxford, England.
 
    INTERNATIONAL SMALL CAP PORTFOLIO -- MARGARET NAYLOR.  Margaret Naylor is a
Principal of Morgan Stanley and works with Dominic Caldecott on Pacific Basin
research and stock selection. She joined the Adviser in March 1987 and has been
primarily responsible for managing the Portfolio's assets since December 1992.
Prior to joining the Adviser she spent three years at the Trade Policy Research
Centre, an independent research unit. Ms. Naylor is a graduate of the University
of York.
 
    EUROPEAN EQUITY PORTFOLIO -- ROBERT SARGENT.  Robert Sargent joined Morgan
Stanley International in May, 1986, and transferred to the Adviser in June,
1987. Mr. Sargent is now a Managing Director of Morgan Stanley and has been
primarily responsible for managing the Portfolio's assets since its inception.
As the fund manager with primary responsibility for continental European stock
selection and portfolio management, Mr. Sargent is closely involved with the
Adviser's fundamental research effort and company visiting program. He is a
graduate of York University, Toronto, Canada.
 
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the Officers and
Board of Directors of the Fund and include day-to-day administration of matters
related to the corporate existence of the Fund, maintenance of its records,
preparation of reports, supervision of the Fund's arrangements with its
custodian and assistance in the preparation of the Fund's registration
statements under federal laws. The Administration Agreement also provides that
the Administrator, through its agents, will provide dividend disbursing and
transfer agent services to the Fund. For its services under the Administration
Agreement, the Fund pays the Adviser a monthly fee which on an annual basis
equals 0.15% of the average daily net assets of each Portfolio.
 
                                       20
<PAGE>
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors such administrative services provided by CGFSC.
Their services are also subject to the supervision of the Board of Directors of
the Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of each Portfolio upon the terms and at the current
offering price described in this Prospectus. Morgan Stanley is not obligated to
sell any certain number of shares of any Portfolio.
 
    The Portfolios currently offer only the classes of shares offered by this
Prospectus. The Portfolios may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares of each Multiclass Portfolio pursuant to Rule 12b-1 under the 1940 Act
(each, a "Plan"). Under each Plan, the Distributor is entitled to receive from
each Multiclass Portfolio a distribution fee, which is accrued daily and paid
quarterly, of 0.25% of the Class B shares' average daily net assets on an
annualized basis. The Distributor expects to reallocate most of its fee to its
investment representatives. The Distributor may, in its discretion, voluntarily
waive from time to time all or any portion of its distribution fee and each of
the Distributor and the Adviser is free to make additional payments out of its
own assets to promote the sale of Fund shares, including payments that
compensate financial institutions for distribution services or shareholder
services.
 
    Each Plan is designed to compensate the Distributor for its services, not to
reimburse the Distributor for its expenses, and the Distributor may retain any
portion of the fee that it does not expend in fulfillment of its obligations to
the Fund.
 
    EXPENSES.  Each Portfolio is responsible for payment of certain other fees
and expenses (including legal fees, accountant's fees, custodial fees and
printing and mailing costs) specified in the Administration and Distribution
Agreements.
 
                               PURCHASE OF SHARES
 
    Class A shares of each Portfolio and Class B shares of each Multiclass
Portfolio may be purchased at the net asset value per share next determined
after receipt of the purchase order by the Portfolio. See "Valuation of Shares."
Shareholders of the International Small Cap Portfolio may be charged a 1.00%
transaction fee, which is payable directly to the International Small Cap
Portfolio, in connection with each purchase and redemption of shares of the
Portfolio. The transaction fee is intended to allocate transaction costs
associated with purchases and redemptions of shares of the Portfolio to
investors actually making such purchases and redemptions rather than to the
Portfolio's other shareholders. The 1.00% fee represents the Adviser's estimate
of such transaction costs, which include the costs of acquiring and disposing of
Portfolio securities. The transaction fee is not a sales
 
                                       21
<PAGE>
charge or load, and is retained by the Portfolio. The fee does not apply to
Portfolios of the Fund other than the International Small Cap Portfolio and is
not charged in connection with the reinvestment of dividends or capital gain
distributions. The fee will not be charged with respect to purchases and
redemptions that do not result in actual transaction costs to the Portfolio.
 
MINIMUM INVESTMENT AND ACCOUNT SIZES; CONVERSION FROM CLASS A TO CLASS B SHARES
 
    For a Portfolio account opened on or after January 2, 1996 (a "New
Account"), the minimum initial investment and minimum account size are $500,000
for Class A shares of each Portfolio and $100,000 for Class B shares of each
Multi-Class Portfolio. Certain advisory or asset allocation accounts, such as
Total Funds Management accounts, managed by Morgan Stanley or its affiliates,
including the Adviser ("Managed Accounts") may purchase Class A shares without
being subject to such minimum initial investment or minimum account size
requirements for a Portfolio account. Employees of the Adviser and certain of
its affiliates may purchase Class A shares subject to conditions, including a
lower minimum initial investment, established by Officers of the Fund.
 
    If the value of a New Account containing Class A shares falls below $500,000
(but remains at or above $100,000) because of shareholder redemption(s), the
Fund will notify the shareholder, and if the account value remains below
$500,000 (but remains at or above $100,000) for a continuous 60-day period, the
Class A shares in such account will convert to Class B shares and will be
subject to the distribution fee and other features applicable to the Class B
shares. The Fund, however, will not convert Class A shares to Class B shares
based solely upon changes in the market that reduce the net asset value of
shares. Under current tax law, conversions between share classes are not a
taxable event to the shareholder.
 
    Shares in a Portfolio account opened prior to January 2, 1996 (a "Pre-1996
Account") were designated Class A shares on January 2, 1996. Shares in a
Pre-1996 Account with a value of $100,000 or more on March 1, 1996 (a
"Grandfathered Class A Account") remained Class A shares regardless of account
size thereafter. Except for shares in a Managed Account, shares in a Pre-1996
Account with a value of less than $100,000 on March 1, 1996 (a "Grandfathered
Class B Account") converted to Class B shares on March 1, 1996. Grandfathered
Class A Accounts and Managed Accounts are not subject to conversion from Class A
shares to Class B shares.
 
    Investors may also invest in the Fund by purchasing shares through a trust
department, broker, dealer, agent, financial planner, financial services firm or
investment adviser. An investor may be charged an additional service or
transaction fee by that institution.
 
    The minimum investment levels may be waived at the discretion of the Adviser
for (i) certain employees and customers of Morgan Stanley or its affiliates and
certain trust departments, brokers, dealers, agents, financial planners,
financial services firms, or investment advisers that have entered into an
agreement with Morgan Stanley or its affiliates; and (ii) retirement and
deferred compensation plans and trusts used to fund such plans, including, but
not limited to, those defined in Section 401(a), 403(b) or 457 of the Code and
"rabbi trusts." The Fund reserves the right to modify or terminate the
conversion features of the shares as stated above at any time upon 60-days
notice to shareholders.
 
    The Adviser reserves the right in its sole discretion to determine which of
such advisory or asset allocation accounts shall be Managed Accounts. For
information regarding Managed Accounts, please contact your Morgan Stanley
account representative or the Fund at the telephone number provided on the cover
of this Prospectus.
 
                                       22
<PAGE>
MINIMUM ACCOUNT SIZES AND INVOLUNTARY REDEMPTION OF SHARES
 
    If the value of a New Multiclass Account falls below $100,000 because of
shareholder redemption(s), the Fund will notify the shareholder, and if the
account value remains below $100,000 for a continuous 60-day period, the shares
in such account are subject to redemption by the Fund and, if redeemed, the net
asset value of such shares will be promptly paid to the shareholder. The Fund,
however, will not redeem shares based solely upon changes in the market that
reduce the net asset value of shares.
 
    Grandfathered Class A Accounts, Grandfathered Class B Accounts and Managed
Accounts are not subject to involuntary redemption. If a shareholder reduces its
total investment in Class A shares of the International Small Cap Portfolio to
less than $500,000, the investment may be subject to redemption. The Fund
reserves the right to modify or terminate the involuntary redemption features of
the shares as stated above at any time upon 60-days notice to shareholders.
 
CONVERSION FROM CLASS B TO CLASS A SHARES
 
    If the value of Class B shares in a Multiclass Portfolio account increases,
whether due to shareholder share purchases or market activity, to $500,000 or
more, the Class B shares will convert to Class A shares. Under current tax law,
such conversion is not a taxable event to the shareholder. Class A shares
converted from Class B shares are subject to the same minimum account size
requirements that are applicable to New Multiclass Accounts containing Class A
shares, as stated above. The Fund reserves the right to modify or terminate this
conversion feature at any time upon 60-days notice to shareholders.
 
INITIAL PURCHASES DIRECTLY FROM THE FUND
 
    The Fund's determination of an investor's eligibility to purchase shares of
a given class will take precedence over the investor's selection of a class.
 
1) BY CHECK.  An account may be opened by completing and signing an Account
   Registration Form and mailing it, together with a check ($500,000 minimum for
   Class A shares of each Portfolio and $100,000 minimum for Class B shares of
   each Multiclass Portfolio, with certain exceptions for Morgan Stanley
   employees and select customers) payable to "Morgan Stanley Institutional
   Fund, Inc. -- [portfolio name]", to:
 
      Morgan Stanley Institutional Fund, Inc.
      P.O. Box 2798
      Boston, Massachusetts 02208-2798
 
Payment will be accepted only in U.S. dollars, unless prior approval for payment
in other currencies is given by the Fund. The classes of shares of the
Portfolio(s) to be purchased should be designated on the Account Registration
Form. For purchases by check, the Fund is ordinarily credited with Federal Funds
within one business day. Thus, your purchase of shares by check is ordinarily
credited to your account at the net asset value per share of the relevant
Portfolio determined on the next business day after receipt.
 
                                       23
<PAGE>
2) BY FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire
   Federal Funds to the Fund's bank account. In order to ensure prompt receipt
   of your Federal Funds Wire, it is important that you follow these steps:
 
A.  Telephone the Fund (toll free: 1-800-548-7786) and provide us with your
    name, address, telephone number, Social Security or Tax Identification
    Number, the portfolio(s) selected, the class selected, the amount being
    wired, and by which bank. We will then provide you with a Fund account
    number. (Investors with existing accounts should also notify the Fund prior
    to wiring funds.)
 
B.  Instruct your bank to wire the specified amount to the Fund's Wire
    Concentration Bank Account (be sure to have your bank include the name of
    the portfolio(s) selected, the class selected, and the account number
    assigned to you) as follows:
 
    The Chase Manhattan Bank
    One Manhattan Plaza
    New York, NY 10081-1000
    ABA #021000021
    DDA #910-2-733293
    Attn: Morgan Stanley Institutional Fund, Inc.
    Ref: (Portfolio name, your account number, your account name)
 
    Please call the Fund at 1-800-548-7786 prior to wiring funds.
 
C.  Complete and sign the Account Registration Form and mail it to the address
    shown thereon.
 
  The purchase price of the Class A and Class B shares of each Portfolio is the
  net asset value next determined after the order is received. See "Valuation of
  Shares." An order received prior to the regular close of the New York Stock
  Exchange ("NYSE"), which is currently 4:00 p.m. Eastern Time, will be executed
  at the price computed on the date of receipt; an order received after the
  regular close of the NYSE will be executed at the price computed on the next
  day the NYSE is open as long as the Transfer Agent receives payment by check
  or in Federal Funds prior to the regular close of the NYSE on such day.
 
  Federal Funds purchase orders will be accepted only on a day on which the Fund
  and Chase (the "Custodian Bank") are open for business. Your bank may charge a
  service fee for wiring Federal Funds.
 
3) BY BANK WIRE.  The same procedure outlined under "By Federal Funds Wire"
   above must be followed in purchasing shares by bank wire. However, money
   transferred by bank wire may or may not be converted into Federal Funds the
   same day, depending on the time the money is received and the bank handling
   the wire. Prior to such conversion, an investor's money will not be invested
   and, therefore, will not be earning dividends. Your bank may charge a service
   fee for wiring funds.
 
ADDITIONAL INVESTMENTS
 
    You may add to your account at any time (minimum additional investment
$1,000 for each portfolio, except for automatic reinvestment of dividends and
capital gains distributions for which there are no minimums) by purchasing
shares at net asset value by mailing a check to the Fund (payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio name]") at the above address or
by wiring monies to the Custodian Bank as outlined above. It is very important
that your account name, the portfolio name and the class selected be specified
in the
 
                                       24
<PAGE>
letter or wire to assure proper crediting to your account. In order to ensure
that your wire orders are invested promptly, you are requested to notify one of
the Fund's representatives (toll-free 1-800-548-7786) prior to the wire date.
Additional investments will be applied to purchase additional shares in the same
class held by a shareholder in a Portfolio account.
 
OTHER PURCHASE INFORMATION
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends. The net asset value of Class B shares will generally be
lower than the net asset value of Class A shares as a result of the distribution
expense charged to Class B shares. It is expected, however, that the net asset
value per share of the two classes will tend to converge immediately after the
recording of dividends which will differ by approximately the amount of the
distribution expense accrual differential between the classes.
 
    In the interest of economy and convenience, and because of the operating
procedures of the Fund, certificates representing shares of the Portfolio(s)
will not be issued. All shares purchased are confirmed to you and credited to
your account on the Fund's books maintained by the Adviser or its agents. You
will have the same rights and ownership with respect to such shares as if
certificates had been issued.
 
    To ensure that checks are collected by the Fund, withdrawals of investments
made by check are not presently permitted until payment for the purchase has
been received, which may take up to eight business days after the date of
purchase. As a condition of this offering, if a purchase is cancelled due to
nonpayment or because your check does not clear, you will be responsible for any
loss the Fund or its agents incur. If you are already a shareholder, the Fund
may redeem shares from your account(s) to reimburse the Fund or its agents for
any loss. In addition, you may be prohibited or restricted from making future
investments in the Fund.
 
    Investors may also invest in the Fund by purchasing shares through the
Distributor.
 
EXCESSIVE TRADING
 
    Frequent trades involving either substantial portfolio assets or a
substantial portion of your account or accounts controlled by you can disrupt
management of a Portfolio and raise its expenses. Consequently, in the interest
of all the stockholders of the Portfolios and the Portfolios' performance, the
Fund may in its discretion bar a stockholder that engages in excessive trading
of shares of any class of a portfolio from further purchases of shares of the
Fund for an indefinite period. The Fund considers excessive trading to be more
than one purchase and sale involving shares of the same class of a Portfolio of
the Fund within any 120-day period. As an example, exchanging shares of
portfolios of the Fund as follows amounts to excessive trading: exchanging
shares of Portfolio A for shares of Portfolio B, then exchanging shares of
Portfolio B for shares of Portfolio C and again exchanging shares of Portfolio C
for shares of Portfolio B within a 120-day period. Two types of transactions are
exempt from these excessive trading restrictions: (i) trades exclusively between
money market portfolios; and (ii) trades done in connection with an asset
allocation service, such as TFM Accounts or accounts managed or advised by the
Adviser and/or any of its affiliates.
 
INVESTMENT IN FUNDS THROUGH A TOTAL FUNDS MANAGEMENT ("TFM") ACCOUNT
 
    In addition to the considerable diversification among individual securities
you receive by investing in a particular Portfolio, you can further reduce risk
by spreading your assets among several different Portfolios that each have
different risk and return characteristics. TFM is an active investment
management service managed
 
                                       25
<PAGE>
by Morgan Stanley or its affiliates, including Morgan Stanley Asset Management
Inc. (each, a "TFM Adviser"), that allocates your investments across a
combination of either Class A or Class B shares of certain of the Portfolios
selected to meet your long-term investment objectives as well as, in certain
circumstances, your current income objectives.
 
    The TFM Adviser has developed investment strategies for TFM Accounts to meet
the diverse financial needs of different investors. You can open a TFM Account
by meeting with one of the investment professionals of a Participating Dealer
who will review your situation and help you identify your long-term investment
and/or current income objectives. After using TFM criteria to determine your
long-term investment and/or current income objectives, you can choose one of
several TFM investment strategies. Based on your chosen strategy, your initial
investment will be allocated among a number of the Class A or Class B shares of
the Portfolios. Depending on market conditions, the TFM Adviser periodically
reallocates the combination of Portfolios or the percentage amounts invested in
the shares of each Portfolio to implement your TFM investment strategy. In
addition, your TFM Account will be periodically rebalanced to maintain your TFM
strategy's current asset allocation mix, if and when the performance of one or
more of the Portfolios unbalances the strategy's mix. You will pay the TFM
Adviser a fee for the TFM Account service that is in addition to and separate
from the fees and expenses you will pay directly or indirectly as an investor in
the Portfolios. See "Fund Expenses."
 
    From time to time, one or more of the Portfolios used for investment by the
TFM Accounts may experience relatively large investments or redemptions due to
the TFM Account allocations or rebalancings recommended by the TFM Adviser.
These transactions will affect the Portfolios, since Portfolios that experience
redemptions as a result of reallocations or rebalancings may have to sell
portfolio securities and Portfolios that receive additional cash will have to
invest it in additional portfolio securities. While it is impossible to predict
the overall impact of these transactions over time, there could be adverse
effects on portfolio management to the extent that Portfolios may be required to
sell securities or invest cash at times when they would not otherwise do so.
These transactions could also have tax consequences if sales of securities
resulted in gains and could also increase transaction costs. The Adviser,
representing the interests of the Portfolios, is committed to minimizing the
impact of TFM Account transactions on the Portfolios. The Adviser, however, will
have a conflict in fulfilling this responsibility in that it also serves as a
TFM Adviser. In that capacity, the Adviser, representing the interests of the
TFM Accounts, also is committed to minimizing the impact of TFM Account
transactions on the Portfolios to the extent consistent with pursuing the
investment objectives of the TFM Accounts. In addition, an affiliate of the TFM
Adviser, the Distributor is compensated on the sale, and may be compensated for
distribution or shareholder services on the sale of shares of the Portfolios.
See "Purchase of Shares" and "Shareholder Services -- Exchange Features." The
Adviser will monitor the impact of TFM Account transactions on the Portfolios.
 
                              REDEMPTION OF SHARES
 
    You may withdraw all or any portion of the amount in your account by
redeeming shares at any time. Please note that redemption proceeds for purchases
made by check may not be received until the payment of the purchase price has
been collected, which may take up to eight business days after purchase. The
Fund will redeem Class A shares of each Portfolio or Class B shares of each
Multiclass Portfolio at the next determined net asset value of shares of the
applicable class. On days that both the NYSE and the Custodian Bank are open for
business, the net asset value per share of each of the Portfolios is determined
at the regular close of trading of the
 
                                       26
<PAGE>
NYSE (currently 4:00 p.m. Eastern Time). Shares of each Portfolio may be
redeemed by mail or telephone. No charge is made for redemptions, except for the
imposition of the 1% transaction fee described under "Purchase of Shares" above,
which may be assessed in connection with redemptions of shares of the
International Small Cap Portfolio. Any redemption proceeds may be more or less
than the purchase price of your shares depending on, among other factors, the
market value of the investment securities held by a Portfolio.
 
BY MAIL
 
    Each Portfolio will redeem its Class A or Class B shares at the net asset
value determined on the date the request is received, if the request is received
in "good order" before the regular close of the NYSE. Your request should be
addressed to Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston,
Massachusetts 02208-2798, except that deliveries by overnight courier should be
addressed to Morgan Stanley Institutional Fund, Inc., c/o Chase Global Funds
Services Company, 73 Tremont Street, Boston, Massachusetts 02108-3913.
 
    "Good order" means that the request to redeem shares must include the
following documentation:
 
        (a)  A letter of instruction or a stock assignment specifying the class
    and number of shares or dollar amount to be redeemed, signed by all
    registered owners of the shares in the exact names in which they are
    registered;
 
        (b) Any required signature guarantees (see "Further Redemption
    Information" below); and
 
        (c)  Other supporting legal documents, if required, in the case of
    estates, trusts, guardianships, custodianships, corporations, pension and
    profit sharing plans and other organizations.
 
    Shareholders who are uncertain of requirements for redemption should consult
with a Fund representative.
 
BY TELEPHONE
 
    Provided you have previously elected the Telephone Redemption Option on the
Account Registration Form, you can request a redemption of your shares by
calling the Fund and requesting the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. In times of drastic market conditions, the telephone redemption option
may be difficult to implement. If you experience difficulty in making a
telephone redemption, your request may be made by regular mail or express mail
and it will be implemented at the net asset value next determined after it is
received. Redemption requests sent to the Fund through express mail must be
mailed to the address of the Dividend Disbursing and Transfer Agent listed under
"General Information." The Fund and the Fund's transfer agent (the "Transfer
Agent") will employ reasonable procedures to confirm that the instructions
communicated by telephone are genuine. These procedures include requiring the
investor to provide certain personal identification information at the time an
account is opened and prior to effecting each transaction requested by
telephone. In addition, all telephone transaction requests will be recorded and
investors may be required to provide additional telecopied written instructions
regarding transaction requests. Neither the Fund nor the Transfer Agent will be
responsible for any loss, liability, cost or expense for following instructions
received by telephone that either of them reasonably believes to be genuine.
 
    To change the commercial bank or account designated to receive redemption
proceeds, a written request must be sent to the Fund at the address above.
Requests to change the bank or account must be signed by each shareholder and
each signature must be guaranteed.
 
                                       27
<PAGE>
FURTHER REDEMPTION INFORMATION
 
    Normally the Fund will make payment for all shares redeemed within one
business day of receipt of the request, but in no event will payment be made
more than seven days after receipt of a redemption request in good order.
However, payments to investors redeeming shares which were purchased by check
will not be made until payment for the purchase has been collected, which may
take up to eight days after the date of purchase. The Fund may suspend the right
of redemption or postpone the date upon which redemptions are effected at times
when the NYSE is closed, or under any emergency circumstances as determined by
the Securities and Exchange Commission (the "Commission").
 
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of a Portfolio to make payment
wholly or partly in cash, the Fund may pay the redemption proceeds in whole or
in part by a distribution in-kind of securities held by a Portfolio in lieu of
cash in conformity with applicable rules of the Commission.
Distributions-in-kind will be made in readily marketable securities. Investors
may incur brokerage charges on the sale of portfolio securities so received in
payment of redemptions.
 
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required for certain redemptions to verify the identity of the
person who has authorized a redemption from your account. Please contact the
Fund for further information.
 
                              SHAREHOLDER SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares that you own in any Portfolio for shares of any
other available portfolio(s) of the Fund (other than the International Equity
Portfolio, which is closed to new investors). In exchanging for shares of a
portfolio with more than one class, the class of shares you receive in the
exchange will be determined in the same manner as any other purchase of shares
and will not be based on the class of shares surrendered for the exchange.
Consequently, the same minimum initial investment and minimum account size for
determining the class of shares received in the exchange will apply. See
"Purchase of Shares." Shares of the portfolios may be exchanged by mail or
telephone. The privilege to exchange shares by telephone is automatic and made
available without shareholder election. Before you make an exchange, you should
read the prospectus of the portfolio(s) in which you seek to invest. Because an
exchange transaction is treated as a redemption followed by a purchase, an
exchange would be considered a taxable event for shareholders subject to tax.
The exchange privilege may be modified or terminated by the Fund at any time
upon 60-days' notice to shareholders.
 
BY MAIL
 
    In order to exchange shares by mail, you should include in the exchange
request the name, class of shares and account number of your current Portfolio,
the name(s) of the portfolio(s) and class(es) of shares into which you intend to
exchange shares, and the signatures of all registered account holders. Send the
exchange request to Morgan Stanley Institutional Fund, Inc., P.O. Box 2798,
Boston, Massachusetts 02208-2798.
 
BY TELEPHONE
 
    When exchanging shares by telephone, have ready the name, class of shares
and account number of your current Portfolio, the name(s) of the portfolio(s)
and class(es) of shares into which you intend to exchange shares, your Social
Security number or Tax I.D. number, and your account address. Requests for
telephone exchanges
 
                                       28
<PAGE>
received prior to 4:00 p.m. (Eastern Time) are processed at the close of
business that same day based on the net asset value of the class(es) of the
portfolios involved in the exchange of shares at the close of business. Requests
received after 4:00 p.m. (Eastern Time) are processed the next business day
based on the net asset value determined at the close of business on such day.
For additional information regarding responsibility for the authenticity of
telephoned instructions, see "Redemption of Shares -- By Telephone" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by writing to Morgan Stanley Institutional Fund, Inc., P.O. Box 2798,
Boston, Massachusetts 02208-2798. As in the case of redemptions, the written
request must be received in good order before any transfer can be made.
Transferring the registration of shares may affect the eligibility of your
account for a given class of the Portfolio's shares may result in involuntary
conversion or redemption of your shares. See "Purchase of Shares" above.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of each of the Portfolios
is determined by dividing the total market value of the Portfolio's investments
and other assets attributable to such class, less any liabilities attributable
to such class, by the total number of outstanding shares of each class of the
Portfolio. Net asset value is calculated separately for each class of the
Portfolios. Net asset value per share is determined as of the regular close of
the NYSE on each day that the NYSE is open for business. Price information on
listed securities is taken from the exchange where the security is primarily
traded. Securities listed on a U.S. securities exchange for which market
quotations are available are valued at the last quoted sale price on the day the
valuation is made. Securities listed on a foreign exchange are valued at their
closing price. Unlisted securities and listed securities not traded on the
valuation date for which market quotations are readily available are valued at a
price within a range not exceeding the current asked price nor less than the
current bid price. The current bid and asked prices are determined based on the
average of the bid and asked prices quoted on such valuation date by reputable
brokers.
 
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily. In addition, bonds and other fixed income securities may be
valued on the basis of prices provided by a pricing service when such prices are
believed to reflect the fair market value of such securities. The prices
provided by a pricing service are determined without regard to bid or last sale
prices but take into account institutional size, trading in similar groups of
securities and any developments related to the specific securities. Securities
not priced in this manner are valued at the most recently quoted bid price or,
when securities exchange valuations are used, at the latest quoted sale price on
the day of valuation. If there is no such reported sale, the latest quoted bid
price will be used. Securities purchased with remaining maturities of 60 days or
less are valued at amortized cost, if it approximates market value. In the event
that amortized cost does not approximate market value, market prices as
determined above will be used.
 
    The value of other assets and securities for which quotations are not
readily available (including restricted and unlisted foreign securities) and
those securities for which it is inappropriate to determine the prices in
 
                                       29
<PAGE>
accordance with the above-stated procedures are determined in good faith at fair
value using methods determined by the Board of Directors. For purposes of
calculating net asset value per share, all assets and liabilities initially
expressed in foreign currencies will be translated into U.S. dollars at the mean
of the bid and asked price for such currencies against the U.S. dollar last
quoted by any major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distribution expense accrual differential among the classes. The
net asset value of Class B shares will generally be lower than the net asset
value of the Class A shares as a result of the distribution expenses charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise the "total return" for each class
of a Portfolio. THESE FIGURES ARE BASED ON HISTORICAL EARNINGS AND ARE NOT
INTENDED TO INDICATE FUTURE PERFORMANCE.
 
    Each of the Portfolios may advertise "total return" which shows what an
investment in a class of a Portfolio would have earned over a specified period
of time (such as one, five or ten years) assuming that all distributions and
dividends by the Portfolio were reinvested in the same class on the reinvestment
dates during the period. Total return does not take into account any federal or
state income taxes that may be payable on dividends and distributions or on
redemption. The Fund may also include comparative performance information in
advertising or marketing the Portfolios' shares, including data from Lipper
Analytical Services, Inc., other industry publications, business periodicals,
rating services and market indices.
 
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains distributions for a class of shares
will be automatically reinvested in additional shares at net asset value, except
that, upon written notice to the Fund or by checking off the appropriate box in
the Distribution Option Section on the Account Registration Form, a shareholder
may elect to receive income dividends and capital gains distributions in cash.
 
    Each Portfolio expects to distribute substantially all of its taxable net
investment income in the form of annual dividends. Net realized capital gains,
if any, after reduction for any available tax loss carryforwards will also be
distributed annually.
 
    Undistributed net investment income is included in a Portfolio's net assets
for the purpose of calculating net asset value per share. Therefore, on the
"ex-dividend" date, the net asset value per share excludes the dividend (i.e.,
is reduced by the per share amount of the dividend). Dividends paid shortly
after the purchase of shares by an investor, although in effect a return of
capital, are taxable to shareholders subject to income tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
 
                                       30
<PAGE>
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of the Portfolios will differ at times.
Expenses of the Portfolios allocated to a particular class of shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of the Portfolios or their shareholders.
Accordingly, shareholders are urged to consult their tax advisers regarding
specific questions as to federal, state and local income taxes.
 
    Each Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other portfolios. Each Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Code, so that the Portfolio will be relieved
of federal income tax on that part of its net investment income and net capital
gain that is distributed to shareholders.
 
    Each Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, net short-term capital gain) to
shareholders. Dividends from a Portfolio's net investment income are taxable to
shareholders as ordinary income, whether received in cash or in additional
shares. Such dividends paid by a Portfolio will generally qualify for the 70%
dividends-received deduction for corporate shareholders only to the extent of
the aggregate qualifying dividend income received by the Portfolio from U.S.
corporations. Each Portfolio will report annually to its shareholders the amount
of dividend income qualifying for such treatment.
 
    Distributions of net capital gain (the excess of net long-term capital gain
over net short-term capital loss) are taxable to shareholders as long-term
capital gain, regardless of how long shareholders have held their shares. Each
Portfolio will send reports annually to its shareholders of the federal income
tax status of all distributions made during the preceding year.
 
    Each Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gain over short-term and long-term capital
loss, including any available capital loss carryforwards) prior to the end of
each calendar year to avoid liability for federal excise tax.
 
    Dividends and other distributions declared by a Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders in that year if the distributions are paid by the Portfolio at
any time during the following January.
 
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any dividends, capital gains distributions and redemption proceeds paid to any
individual or certain other non-corporate shareholder (i) who has failed to
provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Application Form, (ii) who is subject to backup
 
                                       31
<PAGE>
withholding by the Internal Revenue Service, or (iii) who has not certified to
the Fund that such shareholder is not subject to backup withholding. This backup
withholding is not an additional tax, and any amounts withheld may be credited
against the shareholder's ultimate U.S. tax liability.
 
    The sale, exchange or redemption of shares will result in taxable gain or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the sale, exchange or redemption proceeds exceed or are
less than the shareholder's adjusted basis in the sold, exchanged or redeemed
shares. If capital gain distributions have been made with respect to shares that
are sold at a loss after being held for six months or less, then the loss is
treated as a long-term capital loss to the extent of the capital gain
distributions.
 
    Conversion of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisors concerning the
application of state and local income taxes to investments in a Portfolio, which
may differ from the federal income tax consequences described above.
 
    Investment income received by a Portfolio from sources within foreign
countries may be subject to foreign income taxes withheld at the source. To the
extent that a Portfolio is liable for foreign income taxes so withheld, each
Portfolio intends to operate so as to meet the requirements of the Code to pass
through to the shareholders credit for foreign income taxes paid. Although each
Portfolio intends to meet Code requirements to pass through credit for such
taxes, there can be no assurance that each Portfolio will be able to do so.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN A PORTFOLIO.
 
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolio
for their clients.
 
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other remuneration paid to Morgan Stanley or other affiliates must be
fair and reasonable in comparison to those of other broker-dealers for
comparable transactions involving similar securities being purchased or sold
during a comparable time period.
 
                                       32
<PAGE>
PORTFOLIO TURNOVER
 
    The Portfolios generally do not invest for short-term trading purposes,
however, when circumstances warrant, each Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolios will not consider portfolio turnover rate
a limiting factor in making investment decisions consistent with their
respective objectives and policies. As portfolio turnover increases, the
Portfolios may expect to pay correspondingly increased brokerage and trading
costs. In addition to transaction costs, higher portfolio turnover may result in
the realization of capital gains. As discussed under "Taxes," to the extent net
short-term capital gains are realized, any distributions resulting from such
gains are considered ordinary income for federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 38 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of each
Portfolio are currently classified into two classes, the Class A shares and the
Class B shares, except for the International Small Cap, Money Market and
Municipal Money Market Portfolios, which offer only Class A shares.
 
    The shares of each Portfolio, when issued, will be fully paid,
nonassessable, fully transferable and redeemable at the option of the holder.
The shares have no preference as to conversion, exchange, dividends, retirement
or other features and have no pre-emptive rights. The shares of each Portfolio
have non-cumulative voting rights, which means that the holders of more than 50%
of the shares voting for the election of Directors can elect 100% of the
Directors if they choose to do so. Persons or organizations owning 25% or more
of the outstanding shares of a Portfolio may be presumed to "control" (as
defined in the 1940 Act) such Portfolio. Under Maryland law, the Fund is not
required to hold an annual meeting of its shareholders unless required to do so
under the 1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual, semi-annual and quarterly
reports; the financial statements appearing in annual reports are audited by
independent accountants. Monthly unaudited portfolio data is also available from
the Fund upon request.
 
    In addition, the Adviser or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
CUSTODIAN
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs sub-
 
                                       33
<PAGE>
custodians approved by the Board of Directors of the Fund in accordance with
regulations of the Securities and Exchange Commission for the purpose of
providing custodial services for such assets. MSTC may also hold certain
domestic assets for the Fund. For more information on the custodians, see
"General Information -- Custody Arrangements" in the Statement of Additional
Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits its annual financial statements.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       34
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
  GLOBAL EQUITY, INTERNATIONAL EQUITY, INTERNATIONAL SMALL CAP AND
   EUROPEAN EQUITY PORTFOLIOS
   P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                            <C>
      ACCOUNT INFORMATION                            If you need assistance in filling out this form for the Morgan Stanley
      Fill in where applicable                       Institutional Fund, please contact your Morgan Stanley representative
                                                     or call us toll free 1-800-548-7786. Please print all items except
                                                     signature, and mail to the Fund at the address above.
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
         TENANCY IN COMMON
         IS INDICATED)
</TABLE>
 
1.
         First Name    Initial         Last Name
2.
         First Name    Initial         Last Name
         First Name    Initial         Last Name
 
<TABLE>
<C>   <S>                                            <C>
      3. CORPORATIONS,
         TRUSTS AND OTHERS
         Please call the Fund for additional
      documents that may be required to set up
      account and to authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                     <C>                 <C>                   <C>               <C>
Type of Registration:   / / INCORPORATED    / / UNINCORPORATED    / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                            ASSOCIATION                               (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
 
<TABLE>
<C>   <S>                                            <C>
  B)  MAILING ADDRESS
      Please fill in completely, including
      telephone number(s).
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
/ / Non-Resident Alien:
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
 
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
 
<TABLE>
<C>   <S>                                            <C>                                  <C>
  C)  TAXPAYER                                       Enter your Taxpayer Identification Number. For most individual
      IDENTIFICATION                                 taxpayers, this is your Social Security Number.
      NUMBER
      1. INDIVIDUAL
      2.   JOINT TENANTS
           (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
           TENANCY IN COMMON
           IS INDICATED)
      For Custodian account
      of a minor (Uniform
      Gifts/Transfers to Minor
      Acts), give the Social
      Security Number of
      the minor
                                                                                          OR
                                                     1.         TAXPAYER IDENTIFICATION                      SOCIAL SECURITY
                                                     NUMBER ("TIN")                                NUMBER ("SSN")
                                                                                              OR
                                                     2.                             TIN
                                                                                                                             SSN
                                                                                              OR
                                                     TIN
                                                                                                                             SSN
                                                     IMPORTANT TAX INFORMATION
                                                     You (as a payee) are required by law to provide us (as payer) with your
                                                     correct TIN(s) or SSN(s). Accounts that have a missing or incorrect
                                                     TIN(s) or SSN(s) will be subject to backup withholding at a 31% rate on
                                                     dividends, distributions and other payments. If you have not provided us
                                                     with your correct TIN(s) or SSN(s), you may be subject to a $50 penalty
                                                     imposed by the Internal Revenue Service.
                                                     Backup withholding is not an additional tax; the tax liability of
                                                     persons subject to backup withholding will be reduced by the amount of
                                                     tax withheld. If withholding results in an overpayment of taxes, a
                                                     refund may be obtained.
                                                     You may be notified that you are subject to backup withholding under
                                                     Section 3406(a)(1)(C) of the Internal Revenue Code because you have
                                                     underreported interest or dividends or you were required to, but failed
                                                     to, file a return which would have included a reportable interest or
                                                     dividend payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>                             <C>                   <C>
  D)  PORTFOLIO AND                        For Purchase of the following   / / Class A Shares $  / / Class B Shares $
      CLASS SECTION                        Portfolio(s):                   / / Class A Shares $
      (Class A shares minimum $500,000     Global Equity Portfolio         / / Class A Shares $  / / Class B Shares $
      for each Portfolio and Class B       International Equity Portfolio  / / Class A Shares $  / / Class B Shares $
      shares minimum $100,000 for the      International Small Cap
      Global Equity, International         Portfolio
      Equity, and European Equity          European Equity Portfolio
      Portfolios). Please indicate
      Portfolio, class and amount.
                                                                           Total Initial Investment $
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate
      portfolio, manner of
      payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                          <C>
/ / Exchange $ From                                                                     -- - - - - - - - - - -- - -
                            Name of Portfolio                                                   Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on                 -- - - - - - - - - - -- - -
                                                                                      Account No.               (Check
                                                                                (Previously assigned by the Fund)     Digit)
                                                                                                                          Date
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  F)  DISTRIBUTION               Income dividends and capital gains distributions (if any) to
      OPTION                     be reinvested in additional shares unless either box below
                                 is checked.
                                 / / Income dividends to be paid in cash, capital gains
                                 distributions (if any) in shares.
                                 / / Income dividends and capital gains distributions (if
                                 any) to be paid in cash.
</TABLE>
 
<TABLE>
<C>   <S>                             <C>                                       <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone         Name of COMMERCIAL Bank (Not Savings
      AND EXCHANGE                    requests to wire redemption proceeds to   Bank)
      OPTION                          the commercial bank indicated at right    Bank Account No.
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund
      wish to redeem or exchange      account is registered if such requests                                        Bank
      shares by telephone. A          are believed to be authentic.                                                  ABA
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent                                         No.
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated    Name(s) in which your Bank Account is
      YOUR FUND ACCOUNT.              by telephone are genuine. These           Established
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal      Bank's Street
      NOT BE HONORED UNLESS THE BOX   identification information at the time    Address
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by   City  State  Zip
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  H)  INTERESTED PARTY
      OPTION                                                                                                Name
      In addition to the account
      statement sent to my/our registered
      address, I/we hereby authorize the                                                                   Address
      Fund to mail duplicate statements
      to the name and address provided at  City         State         Zip Code
      right.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  I)  DEALER
      INFORMATION
                                           Representative Name              Representative No.             Branch
                                           No.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here ,
</TABLE>
 
<TABLE>
<S>                                  <C>
The undersigned certify that I/we have full authority and legal capacity
to purchase and redeem shares of the Fund and affirm that I/we have
received a current Prospectus of the Morgan Stanley Institutional Fund,
Inc. and agree to be bound by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF
PERJURY THAT THE INFORMATION ON THIS APPLICATION IS COMPLETE AND CORRECT
AND THAT AS REQUIRED BY FEDERAL LAW (PLEASE CHECK APPLICABLE BOXES
BELOW):
 
/ / U.S. CITIZEN(S)/TAXPAYER(S):
 
      / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM
          IS/ARE THE CORRECT SSN(S) OR TIN(S) AND (2) I/WE ARE NOT
          SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE ARE
          EXEMPT FROM BACKUP WITHHOLDING; (B) I/WE HAVE NOT BEEN
          NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT I/WE ARE
          SUBJECT TO BACKUP WITHHOLDING AS A RESULT OF A FAILURE TO
          REPORT ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED
          ME/US THAT I AM/WE ARE NO LONGER SUBJECT TO BACKUP
          WITHHOLDING.
 
      / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE HAVE
          APPLIED, OR INTEND TO APPLY, TO THE IRS OR THE SOCIAL SECURITY
          ADMINISTRATION FOR A TIN OR A SSN AND I/WE UNDERSTAND THAT IF
          I/ WE DO NOT PROVIDE EITHER NUMBER TO CHASE GLOBAL FUNDS
          SERVICES COMPANY ("CGFSC") WITHIN 60 DAYS OF THE DATE OF THIS
          APPLICATION OR IF I/WE FAIL TO FURNISH MY/OUR CORRECT SSN(S)
          OR TIN(S), I/WE MAY BE SUBJECT TO A PENALTY AND A 31% BACKUP
          WITHHOLDING ON DISTRIBUTIONS AND REDEMPTION PROCEEDS. (PLEASE
          PROVIDE EITHER NUMBER ON IRS FORM W-9). YOU MAY REQUEST SUCH
          FORM BY CALLING CGFSC AT 800-282-4404.
 
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
  UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S.
CITIZENS OR RESIDENTS AND I/WE ARE EXEMPT FOREIGN PERSONS AS DEFINED BY
THE INTERNAL REVENUE SERVICE.
 
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY
PROVISION OF THIS DOCUMENT OTHER THAN THE CERTIFICATIONS REQUIRED TO
AVOID BACKUP WITHHOLDING.
 
                                     (X)
(X)                                  Signature (if joint account, both
Signature            Date            must sign)      Date
</TABLE>
<PAGE>
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  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<CAPTION>
                                                    PAGE
                                                    ----
<S>                                                 <C>
Fund Expenses.....................................    2
Financial Highlights..............................    5
Prospectus Summary................................   10
Investment Objectives and Policies................   14
Additional Investment Information.................   16
Investment Limitations............................   19
Management of the Fund............................   19
Purchase of Shares................................   21
Redemption of Shares..............................   26
Shareholder Services..............................   28
Valuation of Shares...............................   29
Performance Information...........................   30
Dividends and Capital Gains Distributions.........   30
Taxes.............................................   31
Portfolio Transactions............................   32
General Information...............................   33
Account Registration Form
</TABLE>
 
                            GLOBAL EQUITY PORTFOLIO
                         INTERNATIONAL EQUITY PORTFOLIO
                       INTERNATIONAL SMALL CAP PORTFOLIO
                           EUROPEAN EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
 
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  Incorporated
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                      P.O. BOX 2798, BOSTON, MA 02208-2798
 
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