MORGAN STANLEY INSTITUTIONAL FUND INC
497, 1998-05-05
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<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
 -----------------------------------------------------------------------------
 
                             FIXED INCOME PORTFOLIO
                            MUNICIPAL BOND PORTFOLIO
                      MORTGAGE-BACKED SECURITIES PORTFOLIO
                             MONEY MARKET PORTFOLIO
                        MUNICIPAL MONEY MARKET PORTFOLIO
 
                               PORTFOLIOS OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
                                ----------------
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company or mutual fund, which offers redeemable shares in
a series of diversified and non-diversified investment portfolios
("portfolios"). The Fund is designed to provide clients with attractive
alternatives for meeting their investment needs. The Fund currently consists of
thirty-two portfolios representing a broad range of investment choices. This
prospectus (the "Prospectus") pertains to the Class A and the Class B shares of
the Fixed Income, Municipal Bond and Mortgage-Backed Securities Portfolios (the
"Non-Money Portfolios") and to the Class A and Class B shares of the Money
Market Portfolio and Class A shares of the Municipal Money Market Portfolio (the
"Money Portfolios") (each, a "Portfolio" and collectively, the "Portfolios").
The Class A and Class B shares currently offered by the Non-Money Portfolios and
the Money Market Portfolio have different minimum investment requirements and
fund expenses. Shares of the Portfolios are offered with no sales charge,
exchange fee or redemption fee. The Mortgage-Backed Securities Portfolio
currently is not being offered.
 
    INVESTMENTS IN THE MONEY MARKET AND MUNICIPAL MONEY MARKET PORTFOLIOS ARE
NEITHER INSURED NOR GUARANTEED BY THE U.S. GOVERNMENT. THERE IS NO ASSURANCE
THAT THE MONEY MARKET AND MUNICIPAL MONEY MARKET PORTFOLIOS WILL BE ABLE TO
MAINTAIN A STABLE NET ASSET VALUE OF $1.00 PER SHARE.
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator") and with Morgan Stanley & Co. Incorporated ("Morgan Stanley")
as Distributor, the Fund makes available to institutional and high net worth
individual investors a series of portfolios which benefit from the investment
expertise and commitment to excellence associated with Morgan Stanley and its
affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under "Prospectus Summary" below. The Fund
currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging Markets,
European Equity, European Real Estate, Global Equity, International Equity,
International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) EQUITY AND FIXED INCOME -- Balanced
Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global
Fixed Income, High Yield and Municipal Bond Portfolios; and (v) MONEY MARKET --
Money Market and Municipal Money Market Portfolios. Additional information about
the Fund is contained in a "Statement of Additional Information" dated May 1,
1998, which is incorporated herein by reference. The Statement of Additional
Information and the prospectuses pertaining to the other portfolios of the Fund
are available upon request and without charge by writing or calling the Fund at
the address and telephone number set forth above.
 
THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
EXCHANGE COMMISSION, NOR HAS THE SECURITIES AND EXCHANGE COMMISSION
       PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS.
               ANY REPRESENTATION TO THE CONTRARY IS A
                               CRIMINAL OFFENSE.
 
                  THE DATE OF THIS PROSPECTUS IS MAY 1, 1998.
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates the expenses and fees that a shareholder of
the Portfolios indicated below will incur:
 
<TABLE>
<CAPTION>
                                                                                            MORTGAGE-             MUNICIPAL
                                                                        FIXED    MUNICIPAL   BACKED      MONEY      MONEY
                                                                       INCOME      BOND     SECURITIES  MARKET     MARKET
SHAREHOLDER TRANSACTION EXPENSES                                      PORTFOLIO  PORTFOLIO  PORTFOLIO  PORTFOLIO  PORTFOLIO
- --------------------------------------------------------------------  ---------  ---------  ---------  ---------  ---------
<S>                                                                   <C>        <C>        <C>        <C>        <C>
Maximum Sales Load Imposed on Purchases
  Class A...........................................................    None       None       None       None       None
  Class B...........................................................    None       None       None       None        N/A
Maximum Sales Load Imposed on Reinvested Dividends
  Class A...........................................................    None       None       None       None       None
  Class B...........................................................    None       None       None       None        N/A
Deferred Sales Load
  Class A...........................................................    None       None       None       None       None
  Class B...........................................................    None       None       None       None        N/A
Redemption Fees
  Class A...........................................................    None       None       None       None       None
  Class B...........................................................    None       None       None       None        N/A
Exchange Fees
  Class A...........................................................    None       None       None       None       None
  Class B...........................................................    None       None       None       None        N/A
</TABLE>
 
<TABLE>
<CAPTION>
                                                                          MORTGAGE-             MUNICIPAL
                                                     FIXED     MUNICIPAL   BACKED     MONEY      MONEY
ANNUAL FUND OPERATING EXPENSES                       INCOME      BOND     SECURITIES  MARKET     MARKET
 (AS A PERCENTAGE OF AVERAGE NET ASSETS)            PORTFOLIO  PORTFOLIO  PORTFOLIO+ PORTFOLIO  PORTFOLIO
- --------------------------------------------------  --------   --------   --------   --------   --------
<S>                                                 <C>        <C>        <C>        <C>        <C>
Management Fee (Net of Fee Waivers)*
  Class A.........................................    0.20%      0.12%      0.20%+     0.30%**    0.30%**
  Class B.........................................    0.20%      0.12%      0.20%+     0.30%      N/A
12b-1 Fees
  Class A.........................................    None       None        None+     None       None
  Class B.........................................    0.15%***   0.25%      0.25%+     0.25%      N/A
Other Expenses
  Class A.........................................    0.25%      0.33%      0.25%+     0.19%      0.20%
  Class B.........................................    0.25%      0.33%      0.25%+     0.19%      N/A
                                                    --------   --------   --------   --------   --------
Total Operating Expenses (Net of Fee Waivers)*
  Class A.........................................    0.45%      0.45%      0.45%+     0.49%**    0.50%**
  Class B.........................................    0.60%      0.70%      0.70%+     0.74%      N/A
                                                    --------   --------   --------   --------   --------
                                                    --------   --------   --------   --------   --------
</TABLE>
 
- ------------------------------
+Estimated.
*The Adviser has agreed to waive its management fees and/or reimburse the
 Portfolios, if necessary, if such fees would cause the total annual operating
 expenses of each of the Portfolios to exceed a specified percentage of its
 respective average daily net assets. As a result of these reductions, the
 Management Fees stated above are lower than the contractual fees stated under
 "Management of the Fund." The Adviser reserves the right to terminate any of
 its fee waivers and/or expense reimbursements at any time in its sole
 discretion. For further information on Fund expenses see "Management of the
 Fund." Set forth below, for each Portfolio as applicable, are the management
 fees and total operating expenses absent such fee waivers and/or expense
 reimbursements as a percent of average daily net assets of the Class A shares
 of the Portfolios and Class B shares of the Non-Money Portfolios and Money
 Market Portfolio, respectively.
 
                                       2
<PAGE>
 
<TABLE>
<CAPTION>
                                                                                   TOTAL OPERATING EXPENSES
                                                                                      ABSENT FEE WAIVERS
                                                            MANAGEMENT FEES      ----------------------------
PORTFOLIO                                                 ABSENT FEE WAIVERS        CLASS A        CLASS B
- ------------------------------------------------------  -----------------------  -------------  -------------
<S>                                                     <C>                      <C>            <C>
Fixed Income..........................................             0.35%              0.60%           0.74%
Municipal Bond........................................             0.35%              0.68%           0.93%
Mortgage-Backed Securities............................             0.35%              0.60%           0.85%
Money Market..........................................             0.30%              0.49%           0.74%
Municipal Money Market................................             0.30%              0.50%          N/A
</TABLE>
 
- ------------------------
 **No fee waiver or expense reimbursement is in effect for this Portfolio.
***The Distributor has agreed to waive 0.10% of the 0.25% distribution fee it is
   entitled to receive from this Portfolio.
 
    The purpose of the table above is to assist the investor in understanding
the various expenses that an investor in the Portfolios will bear directly or
indirectly. Expenses and fees are based on actual figures for the fiscal year
ended December 31, 1997 except that (i) expenses for the Mortgage-Backed
Securities Portfolio are based on estimates and assume that the average daily
net assets of the Mortgage-Backed Securities Portfolio will be $50,000,000 and
(ii) expenses for Class B shares of the Money Market Portfolio assume that
expenses for Class A and Class B shares will differ only by the distribution
expense charged to Class B shares. Due to the continuous nature of Rule 12b-1
fees, long-term Class B shareholders may pay more than the equivalent of the
maximum front-end sales charges otherwise permitted by the National Association
of Securities Dealers, Inc. ("NASD") Conduct Rules.
 
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (i) a 5% annual rate of return, and (ii) redemption
at the end of each time period. As noted in the table above, the Portfolios
charge no redemption fees of any kind. The following example is based on total
operating expenses of the Portfolios after fee waivers.
 
<TABLE>
<CAPTION>
                                           1       3       5      10
                                         YEAR    YEARS   YEARS   YEARS
                                         -----   -----   -----   -----
<S>                                      <C>     <C>     <C>     <C>
Fixed Income Portfolio
  Class A.............................   $  5    $ 14    $ 25    $ 57
  Class B.............................      6      19      33      75
Municipal Bond Portfolio
  Class A.............................      5      14      25      57
  Class B.............................      7      22      39      87
Mortgage-Backed Securities Portfolio*
  Class A.............................      5      14     *       *
  Class B.............................      7      22     *       *
Money Market Portfolio
  Class A.............................      5      16      27      62
  Class B*............................      8      24     *       *
Municipal Money Market Portfolio
  Class A.............................      5      16      28      63
</TABLE>
 
- ------------------------------
* Because this Class or Portfolio was not operational as of the Fund's fiscal
  year end, the Fund has not projected expenses beyond the three-year period
  shown.
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. ACTUAL EXPENSES MAY BE GREATER OR LESS THAN THOSE
SHOWN.
 
                                       3
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following tables provide financial highlights for the Class A and Class
B shares of the Fixed Income and Municipal Bond Portfolios and the Class A
shares of the Money Market and Municipal Money Market Portfolio for each of the
periods presented. The audited financial highlights for each Portfolio's shares
for each of the periods in the five years ended December 31, 1997 are part of
the Fund's financial statements which appear in the Fund's December 31, 1997
Annual Report to Shareholders and which are incorporated by reference into the
Fund's Statement of Additional Information. Each Portfolio's financial
highlights for each of the periods presented have been audited by Price
Waterhouse LLP, whose unqualified report thereon is also incorporated by
reference into the Statement of Additional Information. Additional performance
information is included in the Annual Report. The Annual Report and the
financial statements therein, along with the Statement of Additional
Information, are available at no cost from the Fund at the address and telephone
number noted on the cover page of this Prospectus. No financial highlights
appear for Class A and Class B shares of the Mortgage-Backed Securities
Portfolio and Class B shares of the Money Market Portfolio because the Fund had
not offered those classes of shares as of December 31, 1997. After October 31,
1992, the Fund changed its fiscal year end to December 31. The following
information should be read in conjunction with the financial statements and
notes thereto.
 
                                       4
<PAGE>
                             FIXED INCOME PORTFOLIO
<TABLE>
<CAPTION>
                                                                 CLASS A                                               CLASS B
                      ---------------------------------------------------------------------------------------------   ---------
                                                                                     TWO
                                                                                   MONTHS       YEAR       MAY 15*      YEAR
                                       YEAR ENDED DECEMBER 31,                      ENDED       ENDED        TO         ENDED
                      ---------------------------------------------------------   DEC. 31,    OCT. 31,    OCT. 31,    DEC. 31,
                        1997        1996        1995        1994        1993        1992        1992        1991        1997
                      ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------
<S>                   <C>         <C>         <C>         <C>         <C>         <C>         <C>         <C>         <C>
NET ASSET VALUE,
 BEGINNING OF
 PERIOD.............  $ 10.58     $ 10.81     $  9.82     $ 11.05     $ 10.93     $ 10.92     $ 10.55     $ 10.00     $ 10.58
                      ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------
INCOME FROM
 INVESTMENT
 OPERATIONS
  Net Investment
   Income (1).......     0.65        0.67        0.72        0.59        0.54        0.10        0.69        0.22        0.64
  Net Realized and
   Unrealized Gain
   (Loss) on
   Investments......     0.33       (0.20)       1.06       (0.92)       0.41        0.01        0.39        0.49        0.33
                      ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------
    Total from
     Investment
     Operations.....     0.98        0.47        1.78       (0.33)       0.95        0.11        1.08        0.71        0.97
                      ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------
DISTRIBUTIONS
  Net Investment
   Income...........    (0.68)      (0.70)      (0.79)      (0.53)      (0.56)      (0.10)      (0.69)      (0.16)      (0.66)
  In Excess of Net
   Investment
   Income...........    (0.00)+     (0.00)+        --          --       (0.01)         --          --          --          --
  Net Realized
   Gain.............       --          --          --       (0.37)      (0.26)         --       (0.02)         --          --
  In Excess of Net
   Realized Gain....       --          --          --       (0.00)+        --          --          --          --          --
                      ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------
    Total
    Distributions...    (0.68)      (0.70)      (0.79)      (0.90)      (0.83)      (0.10)      (0.71)      (0.16)      (0.66)
                      ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------
NET ASSET VALUE, END
 OF PERIOD..........  $ 10.88     $ 10.58     $ 10.81     $  9.82     $ 11.05     $ 10.93     $ 10.92     $ 10.55     $ 10.89
                      ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------
                      ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------
TOTAL RETURN........     9.54%       4.61%      18.76%      (3.10)%      9.07%       1.02%      10.61%       7.12%       9.48%
                      ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------
                      ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------   ---------
RATIOS AND
 SUPPLEMENTAL DATA:
  Net Assets, End of
   Period
   (Thousands)......  $183,192    $130,733    $165,527    $209,331    $240,668    $154,210    $146,546    $72,326     $ 4,834
  Ratio of Expenses
   to Average Net
   Assets (1).......     0.45%       0.45%       0.45%       0.45%       0.45%       0.45%**     0.45%       0.45%**     0.60%
  Ratio of Net
   Investment Income
   to Average Net
   Assets (1).......     6.11%       6.30%       6.85%       5.73%       4.97%       5.56%**     6.59%       7.29%**     5.93%
  Portfolio Turnover
   Rate.............      163%        183%        172%        388%        240%         15%        105%         48%        163%
- ----------------------------------
(1) Effect of
    voluntary
    expense
    limitation
    during the
    period:
     Per share
      benefit to net
      investment
      income........    $0.02       $0.02       $0.01       $0.01       $0.02       $0.01       $0.02       $0.01       $0.02
   Ratios before
    expense
    limitation:
     Expenses to
      Average Net
      Assets........     0.60%       0.60%       0.59%       0.58%       0.60%       0.75%**     0.59%       0.81%**     0.74%
     Net Investment
      Income to
      Average Net
      Assets........     5.97%       6.15%       6.71%       5.60%       4.82%       5.26%**     6.45%       6.93%**     5.78%
 
<CAPTION>
 
                       PERIOD
                        FROM
                       JAN. 2,
                       1996***
                         TO
                      DEC. 31,
                        1996
                      ---------
<S>                   <C>
NET ASSET VALUE,
 BEGINNING OF
 PERIOD.............  $ 10.81
                      ---------
INCOME FROM
 INVESTMENT
 OPERATIONS
  Net Investment
   Income (1).......     0.64
  Net Realized and
   Unrealized Gain
   (Loss) on
   Investments......   (0.19)
                      ---------
    Total from
     Investment
     Operations.....     0.45
                      ---------
DISTRIBUTIONS
  Net Investment
   Income...........    (0.68)
  In Excess of Net
   Investment
   Income...........       --
  Net Realized
   Gain.............       --
  In Excess of Net
   Realized Gain....       --
                      ---------
    Total
    Distributions...    (0.68)
                      ---------
NET ASSET VALUE, END
 OF PERIOD..........  $ 10.58
                      ---------
                      ---------
TOTAL RETURN........     4.35%
                      ---------
                      ---------
RATIOS AND
 SUPPLEMENTAL DATA:
  Net Assets, End of
   Period
   (Thousands)......  $ 1,462
  Ratio of Expenses
   to Average Net
   Assets (1).......     0.60%**
  Ratio of Net
   Investment Income
   to Average Net
   Assets (1).......     6.15%**
  Portfolio Turnover
   Rate.............      183%
- --------------------
(1) Effect of
    voluntary
    expense
    limitation
    during the
    period:
     Per share
      benefit to net
      investment
      income........    $0.01
   Ratios before
    expense
    limitation:
     Expenses to
      Average Net
      Assets........     0.74%**
     Net Investment
      Income to
      Average Net
      Assets........     6.01%**
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
  + Amount is less than $0.01 per share.
 
                                       5
<PAGE>
                            MUNICIPAL BOND PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                 CLASS A
                                                -----------------------------------------             CLASS B
                                                                                             --------------------------
                                                                              PERIOD FROM                   PERIOD FROM
                                                                              JANUARY 18,                   JANUARY 2,
                                                                               1995* TO        PERIOD       1996*** TO
                                                 YEAR ENDED DECEMBER 31,       DECEMBER         ENDED        DECEMBER
                                                --------------------------        31,        NOVEMBER 5,        31,
                                                  1997++          1996           1995          1997++          1996
                                                -----------    -----------    -----------    -----------    -----------
<S>                                             <C>            <C>            <C>            <C>            <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........     $ 10.25        $ 10.37        $ 10.00        $ 10.24        $ 10.37
                                                -----------    -----------    -----------    -----------    -----------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)..................        0.47           0.49           0.44           0.08           0.44
  Net Realized and Unrealized Gain (Loss) on
   Investments...............................        0.25          (0.12)          0.42           0.14          (0.08)
                                                -----------    -----------    -----------    -----------    -----------
    Total from Investment Operations.........        0.72           0.37           0.86           0.22           0.36
                                                -----------    -----------    -----------    -----------    -----------
DISTRIBUTIONS
  Net Investment Income......................       (0.46)         (0.49)         (0.45)         (0.08)         (0.49)
  In Excess of Net Investment Income.........       (0.00)+       --              (0.00)+       --             --
  Net Realized Gain..........................       (0.00)+       --              (0.04)        --             --
  In Excess of Net Realized Gain.............       (0.00)+       --             --             --             --
                                                -----------    -----------    -----------    -----------    -----------
    Total Distributions......................       (0.46)         (0.49)         (0.49)         (0.08)         (0.49)
                                                -----------    -----------    -----------    -----------    -----------
NET ASSET VALUE, END OF PERIOD...............     $ 10.51        $ 10.25        $ 10.37        $ 10.38        $ 10.24
                                                -----------    -----------    -----------    -----------    -----------
                                                -----------    -----------    -----------    -----------    -----------
TOTAL RETURN.................................        7.25%          3.67%          8.80%         (0.01)%         3.55%
                                                -----------    -----------    -----------    -----------    -----------
                                                -----------    -----------    -----------    -----------    -----------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)......     $60,541        $40,227        $45,869        $     0        $    69
  Ratio of Expenses to Average Net Assets
   (1).......................................        0.45%          0.45%          0.45%**        0.70%**        0.70%**
  Ratio of Net Investment Income to Average
   Net Assets (1)............................        4.55%          4.77%          4.61%**        4.43%**        4.56%**
  Portfolio Turnover Rate....................          80%            45%           180%        N/A                45%
</TABLE>
 
- ------------------------------
 
<TABLE>
<C>  <S>                                        <C>            <C>            <C>            <C>            <C>
(1)  Effect of voluntary expense limitation
      during the period:
       Per share benefit to net investment
        income...............................       $0.02          $0.03          $0.03        $0.00    +       $0.03
     Ratios before expense limitation:
       Expenses to Average Net Assets........      0.68    %        0.73  %        0.73  %**    0.93    %**      0.98  %**
       Net Investment Income to Average Net
        Assets...............................      4.33    %        4.50  %        4.33  %**    4.19    %**      4.28  %**
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 ** Annualized
*** The Portfolio began offering Class B shares on January 2, 1996.
  + Amount is less than $0.01 per share.
 ++ Per share amounts for the year ended December 31, 1997 and for the period
    ended November 5, 1997 are based on average shares outstanding. As of
    November 5, 1997, and for the period from March 19 through October 30, 1997,
    there were no outstanding Class B shares for the Municipal Bond Portfolio.
 
                                       6
<PAGE>
                             MONEY MARKET PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                      CLASS A
                    ------------------------------------------------------------------------------------------------------------
                                                                                 TWO
                                                                               MONTHS                                  NOV. 15,
                                    YEAR ENDED DECEMBER 31,                     ENDED       YEAR ENDED OCTOBER 31,     1988* TO
                    --------------------------------------------------------  DEC. 31,   ----------------------------  OCT. 31,
                      1997        1996        1995        1994       1993       1992      1992     1991       1990       1989
                    ---------   ---------  ----------  ----------  ---------  ---------  ------  ---------  ---------  ---------
<S>                 <C>         <C>        <C>         <C>         <C>        <C>        <C>     <C>        <C>        <C>
NET ASSET VALUE,
 BEGINNING OF
 PERIOD...........  $   1.000   $   1.000  $  1.000    $  1.000    $  1.000   $  1.000   $1.000  $  1.000   $  1.000   $  1.000
                    ---------   ---------  ----------  ----------  ---------  ---------  ------  ---------  ---------  ---------
INCOME FROM
 INVESTMENT
 OPERATIONS
  Net Investment
   Income (1).....      0.051       0.049     0.054       0.040       0.027      0.005   0.039      0.062      0.079      0.085
                    ---------   ---------  ----------  ----------  ---------  ---------  ------  ---------  ---------  ---------
DISTRIBUTIONS
  Net Investment
   Income.........     (0.051)     (0.049)   (0.054)     (0.040)     (0.027)    (0.005)  (0.039)   (0.062)    (0.079)    (0.085)
  In Excess of Net
   Investment
   Income.........         --          --        --          --       0.000+        --      --         --         --         --
                    ---------   ---------  ----------  ----------  ---------  ---------  ------  ---------  ---------  ---------
    Total
  Distributions...     (0.051)     (0.049)   (0.054)     (0.040)     (0.027)    (0.005)  (0.039)   (0.062)    (0.079)    (0.085)
                    ---------   ---------  ----------  ----------  ---------  ---------  ------  ---------  ---------  ---------
NET ASSET VALUE,
 END OF PERIOD....  $   1.000   $   1.000  $  1.000    $  1.000    $  1.000   $  1.000   $1.000  $  1.000   $  1.000   $  1.000
                    ---------   ---------  ----------  ----------  ---------  ---------  ------  ---------  ---------  ---------
                    ---------   ---------  ----------  ----------  ---------  ---------  ------  ---------  ---------  ---------
TOTAL RETURN......       5.20%       5.03%     5.51%       3.84%       2.76%      0.50%   3.77%      6.37%      8.16%       8.8%
                    ---------   ---------  ----------  ----------  ---------  ---------  ------  ---------  ---------  ---------
                    ---------   ---------  ----------  ----------  ---------  ---------  ------  ---------  ---------  ---------
RATIOS AND
 SUPPLEMENTAL
 DATA:
  Net Assets, End
   of Period
   (Thousands)....  $1,506,210  $1,284,633 $836,693    $690,503    $657,163   $599,172   $612,968 $607,087  $516,182   $158,582
  Ratio of
   Expenses to
   Average Net
   Assets (1).....       0.49%       0.52%     0.51%       0.49%       0.53%      0.55%**  0.52%     0.53%      0.55%      0.55%**
  Ratio of Net
   Investment
   Income to
   Average Net
   Assets (1).....       5.12%       4.92%     5.37%       3.77%       2.71%      3.11%**  3.74%     6.11%      7.87%      8.80%**
- ----------------------------------
(1) Effect of
    voluntary
    expense
    limitation
    during the
    period:
     Per share
      benefit to
      net
      investment
      income......        N/A         N/A       N/A         N/A      $0.000+    $0.000+    N/A        N/A        N/A        N/A
   Ratios before
    expense
    limitation:
     Expenses to
      Average Net
      Assets......        N/A         N/A       N/A         N/A        0.54%      0.59%**   N/A       N/A       0.58%      0.55%**
     Net
      Investment
      Income to
      Average Net
      Assets......        N/A         N/A       N/A         N/A        2.70%      3.07%**   N/A       N/A       7.85%       N/A
</TABLE>
 
- --------------------------------------------------------------------------------
 
 * Commencement of operations
 
** Annualized
 
 + Amount if less than $0.001 per share.
 
                                       7
<PAGE>
                        MUNICIPAL MONEY MARKET PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                                         TWO
                                                                                       MONTHS                             FEB.
                                                                                        YEAR                             10* TO
                                         YEAR ENDED DECEMBER 31,                        ENDED    YEAR ENDED OCTOBER 31,   OCT.
                      --------------------------------------------------------------  DEC. 31,   ----------------------   31,
                         1997          1996         1995         1994        1993       1992      1992    1991    1990    1989
                      -----------   -----------  -----------  -----------  ---------  ---------  ------  ------  ------  ------
<S>                   <C>           <C>          <C>          <C>          <C>        <C>        <C>     <C>     <C>     <C>
NET ASSET VALUE,
 BEGINNING OF
 PERIOD.............  $  1.000      $  1.000     $  1.000     $  1.000     $  1.000   $  1.000   $1.000  $1.000  $1.000  $1.000
                      -----------   -----------  -----------  -----------  ---------  ---------  ------  ------  ------  ------
INCOME FROM
 INVESTMENT
 OPERATIONS
  Net Investment
   Income (1).......     0.031         0.030        0.034        0.020        0.019      0.004   0.026   0.043   0.054   0.046
                      -----------   -----------  -----------  -----------  ---------  ---------  ------  ------  ------  ------
DISTRIBUTIONS
  Net Investment
   Income...........    (0.031)       (0.030)      (0.034)      (0.020)      (0.019)    (0.004)  (0.026) (0.043) (0.054) (0.046)
  In Excess of Net
   Investment
   Income...........        --            --           --           --       (0.000)+       --      --      --      --      --
                      -----------   -----------  -----------  -----------  ---------  ---------  ------  ------  ------  ------
    Total
    Distributions...    (0.031)       (0.030)      (0.034)      (0.020)      (0.019)    (0.004)  (0.026) (0.043) (0.054) (0.046)
                      -----------   -----------  -----------  -----------  ---------  ---------  ------  ------  ------  ------
NET ASSET VALUE, END
 OF PERIOD..........  $  1.000      $  1.000     $  1.000     $  1.000     $  1.000   $  1.000   $1.000  $1.000  $1.000  $1.000
                      -----------   -----------  -----------  -----------  ---------  ---------  ------  ------  ------  ------
                      -----------   -----------  -----------  -----------  ---------  ---------  ------  ------  ------  ------
TOTAL RETURN........     3.17%          3.02%        3.44%        2.44%        1.91%      0.37%   2.74%   4.35%   5.51%    4.3%
                      -----------   -----------  -----------  -----------  ---------  ---------  ------  ------  ------  ------
                      -----------   -----------  -----------  -----------  ---------  ---------  ------  ------  ------  ------
RATIOS AND
 SUPPLEMENTAL DATA:
  Net Assets, End of
   Period
   (Thousands)......  $804,607      $721,410     $451,519     $359,444     $266,524   $208,866   $206,691 $166,953 $102,195 $38,540
  Ratio of Expenses
   to Average Net
   Assets (1).......     0.50%          0.53%        0.52%        0.51%        0.54%      0.57%**  0.55%  0.56%   0.51%   0.32%**
  Ratio of Net
   Investment Income
   to Average Net
   Assets (1).......     3.14%          2.98%        3.38%        2.42%        1.89%      2.31%**  2.66%  4.18%   5.38%   6.05%**
- ------------------------------
(1) Effect of
    voluntary
    expense
    limitation
    during the
    period:
     Per share
      benefit to net
      investment
      income........       N/A           N/A          N/A          N/A       $0.000+    $0.000+    N/A     N/A   $0.001    N/A
   Ratios before
    expense
    limitation:
     Expenses to
      Average Net
      Assets........       N/A           N/A          N/A          N/A         0.56%      0.67%**   N/A    N/A    0.63%   0.32%**
     Net Investment
      Income to
      Average Net
      Assets........       N/A           N/A          N/A          N/A         1.87%      2.21%**   N/A    N/A    5.26%    N/A
</TABLE>
 
- --------------------------------------------------------------------------------
 
 * Commencement of operations
 
** Annualized.
 
 + Amount is less than $0.001 per share.
 
                                       8
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional and high
net worth individual investors a broad range of investment choices coupled with
the advantages of a no-load mutual fund with Morgan Stanley and its affiliates
providing customized services as Adviser, Administrator and Distributor. Each
portfolio offers Class A shares and Class B shares, except the International
Small Cap and Municipal Money Market Portfolios which offer only Class A shares.
Each portfolio has its own investment objective and policies designed to meet
its specific goals. The investment objective of each Portfolio described in this
Prospectus is as follows:
 
    - The FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
      with the preservation of capital by investing in a diversified portfolio
      of fixed income securities.
 
    - The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of current
      income consistent with preservation of principal by investing in municipal
      obligations, the interest on which is exempt from federal income tax.
 
    - The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a level
      of current income as is consistent with the preservation of capital by
      investing primarily in a variety of investment grade mortgage-backed
      securities.
 
    - The MONEY MARKET PORTFOLIO seeks to maximize current income and preserve
      capital while maintaining high levels of liquidity through investing in
      high quality money market instruments with remaining maturities of one
      year or less.
 
    - The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current tax-exempt
      income and preserve capital while maintaining high levels of liquidity
      through investing in high quality money market instruments with remaining
      maturities of one year or less which are exempt from federal income tax.
 
    The other portfolios of the Fund are described in other prospectuses which
may be obtained from the Fund at the address and telephone number noted on the
cover page of this Prospectus. The investment objectives of these other
portfolios are listed below:
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    - The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
      appreciation by investing in accordance with country weightings determined
      by the Adviser in equity securities of non-U.S. issuers which, in the
      aggregate, replicate broad country indices.
 
    - The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of Asian issuers.
 
    - The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
      appreciation by investing primarily in equity securities of companies in
      the Asian real estate industry.
 
    - The CHINA GROWTH PORTFOLIO seeks to provide long-term capital appreciation
      by investing primarily in equity securities of issuers in The People's
      Republic of China, Hong Kong and Taiwan.
 
    - The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of emerging country issuers.
 
                                       9
<PAGE>
    - The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of European issuers.
 
    - The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income and
      long-term capital appreciation by investing primarily in equity securities
      of companies in the European real estate industry.
 
    - The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of issuers throughout the world,
      including U.S. issuers.
 
    - The GOLD PORTFOLIO seeks long-term capital appreciation by investing
      primarily in equity securities of foreign and domestic issuers engaged in
      gold-related activities.
 
    - The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of non-U.S. issuers.
 
    - The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of non-U.S. issuers domiciled in
      EAFE countries.
 
    - The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
      by investing primarily in equity securities of non-U.S. issuers with
      equity market capitalizations of less than $1 billion.
 
    - The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of Japanese issuers.
 
    - The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of Latin American issuers and,
      from time to time, debt securities issued or guaranteed by Latin American
      governments or governmental entities.
 
    U.S. EQUITY:
 
    - The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by investing
      primarily in corporate equity and equity-linked securities.
 
    - The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation by
      investing primarily in growth-oriented equity securities of small- to
      medium-sized corporations.
 
    - The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
      investing in growth-oriented equity securities of medium and large
      capitalization companies.
 
    - The MICROCAP PORTFOLIO seeks long-term capital appreciation by investing
      primarily in growth-oriented equity securities of small corporations.
 
    - The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total return by
      investing in equity securities of small- to medium-sized companies which
      the Adviser believes to be undervalued.
 
    - The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by investing
      primarily in equity securities of companies that, in the opinion of the
      Adviser, are expected to be benefit from their involvement in technology
      and technology-related industries.
 
    - The U.S. EQUITY PLUS PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of issuers included in the S&P
      500 Index ("S&P 500").
 
    - The U.S. REAL ESTATE PORTFOLIO seeks to provide above-average current
      income and long-term capital appreciation by investing primarily in equity
      securities of companies in the U.S. real estate industry, including
      substantial investment in real estate investment trusts.
 
                                       10
<PAGE>
    - The VALUE EQUITY PORTFOLIO seeks high total return by investing in equity
      securities which the Adviser believes to be undervalued relative to the
      stock market in general at the time of purchase.
 
    EQUITY AND FIXED INCOME:
 
    - The BALANCED PORTFOLIO seeks high total return while preserving capital by
      investing in a combination of equity securities which the Adviser believe
      to be undervalued and fixed income securities.
 
    FIXED INCOME:
 
    - The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by investing
      primarily in debt securities of government, government-related and
      corporate issuers located in emerging countries.
 
    - The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
      of return while preserving capital by investing in fixed income securities
      of issuers throughout the world, including U.S. issuers.
 
    - The HIGH YIELD PORTFOLIO seeks to maximize total return by investing in a
      diversified portfolio of high yield fixed income securities that offer a
      yield above that generally available on debt securities in the four
      highest rating categories of the recognized rating services.
 
   THE CHINA GROWTH, GOLD, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS
   ARE CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley Dean Witter & Co., acts as investment adviser to the Fund and each of
its portfolios. As of March 31, 1998, Morgan Stanley Asset Management Inc. and
its affiliated institutional asset management companies managed assets of
approximately $166 billion, including assets under fiduciary advice. See
"Management of the Fund -- Investment Adviser" and "Management of the Fund --
Administrator."
 
HOW TO INVEST
 
    Class A shares of each Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of each
Non-Money Portfolio are offered at net asset value with no sales commission, but
with a 12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25% of
the Class B shares average daily net assets on an annualized basis. The
Distributor has agreed to waive 0.10% of the 0.25% 12b-1 fee with respect to the
Fixed Income Portfolio. The minimum initial investment, generally, is $500,000
for Class A shares of each Portfolio and $100,000 for Class B shares of each
Non-Money Portfolio. There is no minimum investment for Class B shares of the
Money Market Portfolio. The minimum initial investment amount is reduced for
certain categories of investors. For additional information on how to purchase
shares and minimum initial investments, see "Purchase of Shares."
 
HOW TO REDEEM
 
    Class A shares or Class B shares of each Portfolio may be redeemed at any
time, without cost, at the net asset value per share of the applicable class
next determined after receipt of the redemption request. The redemption price
may be more or less than the purchase price. Certain redemptions that cause the
value of an account to remain for a continuous 60-day period below the minimum
investment amount for Class A shares or Class B shares may result in involuntary
redemption or automatic conversion. For additional information on how to redeem
shares and involuntary redemption or conversion, see "Purchase of Shares" and
"Redemption of Shares."
 
                                       11
<PAGE>
RISK FACTORS
 
    Investing in each of the Portfolios entails certain risks and considerations
of which an investor should be aware. The Portfolios' share prices and
investment returns fluctuate and, when redeemed, an investment in the Portfolios
may be worth more or less than its original cost. The investment policies of the
Portfolios may entail the following risk factors:
 
    - FIXED INCOME SECURITIES. Each Portfolio will be subject to credit risk and
      market risk associated with investment in fixed income securities. Credit
      risk is the possibility that an issuer may be unable to meet scheduled
      principal and interest payments. Market risk is the possibility that a
      change in interest rates or the market's perception of the issuer's
      prospects may adversely affect the value of a fixed income security.
 
    - MORTGAGE-BACKED SECURITIES. The Fixed Income, Mortgage-Backed Securities
      and Money Market Portfolios may invest in mortgage-backed securities.
      Mortgage-backed securities represent an interest in a pool of underlying
      mortgage loans. They are sensitive to changes in interest rates, but may
      respond to these changes in a manner different from other fixed income
      securities due to the possibility of prepayment of the underlying mortgage
      loans. As a result, it is not possible to determine in advance the actual
      maturity date or average life of a mortgage-backed security. Rising
      interest rates tend to discourage refinancings, with the result that the
      average life and volatility of the security will increase and its market
      price will decrease. When interest rates fall, mortgage-backed securities
      may not gain as much in market value because additional mortgage
      prepayments must be reinvested at lower interest rates.
 
    - FOREIGN INVESTMENT. The Fixed Income Portfolio may invest in the
      securities of foreign issuers. The risks of foreign investment include
      fluctuations in foreign currency values, political events affecting the
      country of issuance and potentially greater market volatility and lower
      liquidity.
 
    - DERIVATIVES. Each Non-Money Portfolio may invest in instruments that
      derive their values from those of specified securities, indices,
      currencies or other points of reference. These derivatives, including
      those used to manage risk, are themselves subject to the risks of the
      different markets in which they are traded and, therefore, may or may not
      serve their intended purposes.
 
For additional information about risk factors, see also "Investment Objectives
and Policies" and "Additional Investment Information."
 
                                       12
<PAGE>
                       INVESTMENT OBJECTIVES AND POLICIES
 
    The investment objective of each Portfolio is described below, together with
the policies each Portfolio will employ in its efforts to achieve its objective.
Each Portfolio's investment objective is a fundamental policy which may not be
changed without the approval of a majority of the Portfolio's outstanding voting
securities. There is no assurance that the Portfolios will attain their
objectives. In addition to the investments and strategies described below, the
Portfolios may invest in certain securities and obligations as set forth in
"Additional Investment Information" and as described under "Investment
Objectives and Policies" in the Statement of Additional Information. The
investment policies described below are not fundamental policies unless
otherwise noted and may be changed without shareholder approval.
 
THE FIXED INCOME PORTFOLIO
 
    The Fixed Income Portfolio seeks to produce a high total return consistent
with the preservation of capital by investing primarily in a diversified
portfolio of U.S. Government securities, corporate bonds (including
competitively priced Eurodollar bonds), mortgage-backed securities and other
fixed income securities, such as certificates of deposit and short-term money
market instruments. Short- and intermediate-term bonds form the core of the
Portfolio, and long-term bonds (i.e., those with maturities over ten years) are
purchased on a short-term opportunistic basis when the Adviser believes they
will enhance return without significantly increasing risk. The Adviser sets an
annual target rate of return for the Portfolio based on current and projected
market and economic conditions and manages the Portfolio conservatively --
primarily through gradual shifts in maturities in attempting to achieve this
target rate.
 
    The Portfolio will typically invest between 50% and 75% of its total assets
in U.S. Government and mortgage-backed securities. The Portfolio will purchase
corporate bonds that generally are rated in the two highest rating categories by
Moody's Investors Service, Inc. ("Moody's") (Aaa or Aa) or Standard & Poor's
Ratings Group ("S&P") (AAA or AA). The Portfolio will not invest in a corporate
bond if it is not rated at least investment grade by either rating agency at the
time of investment. The Portfolio may invest up to 15% of its assets in fixed
income instruments denominated in foreign currencies and issued by corporate or
governmental issuers when the Adviser feels that the currency component and
underlying market characteristics of such obligations will add value to the
Portfolio.
 
THE MUNICIPAL BOND PORTFOLIO
 
    The Municipal Bond Portfolio seeks to produce a high level of current income
consistent with preservation of principal by investing in a portfolio consisting
primarily of intermediate- and long-term investment grade municipal obligations
("Municipal Obligations"), the interest on which is exempt from federal income
tax. Municipal Obligations include notes, bonds and other securities issued by
or on behalf of states, territories and possessions of the United States and the
District of Columbia, and their political subdivisions, agencies and
instrumentalities, on which the interest paid is, in the opinion of counsel for
the issuer or the Portfolio, exempt from federal income tax.
 
    The Portfolio will invest only in Municipal Obligations if they are
investment grade securities. Investment grade securities are (i) bonds rated
within one of the four highest rating categories of Moody's (Aaa, Aa, A or Baa)
or S&P (AAA, AA, A or BBB); (ii) notes rated within one of the two highest
rating categories of Moody's (MIG1 or MIG2) or one of the two highest rating
categories of S&P (SP-1 or SP-2); (iii) commercial paper rated P-1 or P-2 by
Moody's or A-1 or A-2 by S&P; (iv) variable rate securities rated VMIG1 or VMIG2
by Moody's; and
 
                                       13
<PAGE>
(v) unrated Municipal Obligations that the Adviser believes are of comparable
quality to securities in the foregoing rating categories. Bonds rated Baa by
Moody's or BBB by S&P have speculative characteristics. Under normal
circumstances, the Portfolio will invest at least 80% of its net assets in
Municipal Obligations (or futures contracts or options on futures relating
thereto), that are rated investment grade at the time of investment. This policy
is fundamental and may not be changed without the approval of a majority of the
Portfolio's outstanding voting securities.
 
    Although there are no maturity restrictions on the Municipal Obligations in
which the Portfolio invests, it is currently anticipated that the average
maturity will range between 7 and 20 years. Under normal circumstances, at least
65% of the Portfolio's net assets will be invested in Municipal Obligations
having an initial maturity of more than one year. The Adviser will actively
manage the Portfolio, and adjust its average maturity (including by the use of
futures contracts and options on futures), depending on its assessment of the
relative yields available on securities of different maturities and its
expectations of future changes in interest rates. During periods of rising
interest rates and declining prices, the average maturity of the Portfolio may
be shorter, while during periods of declining interest rates and rising prices,
the Portfolio may have a longer average maturity. The Portfolio will not invest
more than 20% of its net assets in Municipal Obligations the interest on which
is subject to alternative minimum tax.
 
    The Portfolio may also invest up to 20% of its net assets in cash, cash
equivalents, U.S. Government securities and taxable corporate investment grade
securities. U.S. Government securities consist of direct obligations of the U.S.
Treasury and securities issued or guaranteed by agencies or instrumentalities of
the U.S. Government. Securities issued or guaranteed by agencies or
instrumentalities may be backed by the full faith and credit of the United
States (such as securities issued by the Government National Mortgage
Association ("GNMA")), or supported by the issuing agency's right to borrow from
the U.S. Treasury (such as securities issued by the Federal Home Loan Banks), or
backed only by the credit of the issuing instrumentality such as securities
issued by Fannie Mae).
 
THE MORTGAGE-BACKED SECURITIES PORTFOLIO
 
    The Mortgage-Backed Securities Portfolio seeks to produce as high a level of
current income as is consistent with the preservation of capital by investing
primarily in mortgage-backed securities either (i) issued or guaranteed by the
U.S. Government, or (ii) rated A or higher by Moody's or S&P or, if unrated,
determined by the Adviser to be of comparable quality.
 
    The Portfolio will invest in mortgage-backed securities that are either (i)
issued or guaranteed by the U.S. Government or one of its agencies or
instrumentalities, or (ii) at the time of investment rated within one of the
three highest rating categories of Moody's (Aaa, Aa or A) or S&P (AAA, AA or A),
or if unrated, determined by the Adviser to be of comparable quality. Under
normal circumstances, the Adviser expects that at least 75% of the Portfolio's
net assets will be invested in mortgage-backed securities issued or guaranteed
by the U.S. Government, its agencies or instrumentalities or rated Aaa by
Moody's or AAA by S&P. Up to 15% of the Portfolio's net assets may be invested
in mortgage-backed securities rated A by Moody's or S&P.
 
    The Adviser expects that short- and intermediate-term mortgage-backed
securities will form the core of the Portfolio, with long-term securities (i.e.,
with maturities over ten years) being purchased when the Adviser believes that
they will enhance return without significantly increasing risk. The Adviser sets
an annual target
 
                                       14
<PAGE>
rate of return for the Portfolio based on current and projected market and
economic conditions and manages the Portfolio conservatively -- primarily
through gradual shifts in maturities -- in attempting to achieve this target
rate.
 
THE MONEY MARKET PORTFOLIO
 
    The Money Market Portfolio seeks to maximize current income and preserve
capital while maintaining high levels of liquidity by investing in the following
high quality money market instruments which have remaining maturities of one
year or less. The Portfolio's average maturity (on a dollar-weighted basis) will
not exceed 90 days. The Portfolio expects to maintain a net asset value of $1.00
per share. There can be no assurance, however, that the Portfolio will be
successful in maintaining a net asset value of $1.00 per share.
 
    U.S. GOVERNMENT OBLIGATIONS.  The Portfolio may invest in obligations issued
or guaranteed by the U.S. Government, such as U.S. Treasury securities and those
backed by the full faith and credit of the United States, such as obligations of
GNMA, the Farmers Home Administration and the Export-Import Bank. The Portfolio
may also invest in obligations issued or guaranteed by U.S. Government agencies
or instrumentalities where the Portfolio must look principally to the issuing or
guaranteeing agency for ultimate repayment; some examples of agencies or
instrumentalities issuing these obligations are the Federal Farm Credit System
and the Federal Home Loan Banks.
 
    MORTGAGE-BACKED SECURITIES.  The Portfolio may invest in certain high
quality mortgage-backed securities.
 
    BANK OBLIGATIONS.  The Portfolio may invest in high quality U.S.
dollar-denominated negotiable certificates of deposit, time deposits, deposit
notes and bankers' acceptances of (i) banks, savings and loan associations and
savings banks which have more than $2 billion in total assets and are organized
under federal or state law; (ii) foreign branches of these banks ("Euros"); and
(iii) U.S. branches of foreign banks of equivalent size ("Yankees"). The
Portfolio may also invest in U.S. dollar-denominated obligations of the
International Bank for Reconstruction and Development ("World Bank"). These
obligations are supported by appropriated but unpaid commitments of the World
Bank's member countries, and there is no assurance these commitments will be
undertaken or met in the future.
 
    COMMERCIAL PAPER; CORPORATE BONDS.  The Portfolio may invest in high quality
commercial paper and corporate bonds issued by U.S. corporations. The Portfolio
may also invest in commercial paper issued by foreign corporations if the issuer
is a direct subsidiary of a U.S. corporation, the obligation is U.S. dollar-
denominated and is not subject to foreign withholding tax, and the aggregate of
these foreign investments does not exceed 10% of the Portfolio's net assets.
 
    QUALITY INFORMATION.  The Portfolio will limit its portfolio investments to
those instruments that present minimal credit risks and are of "eligible
quality" as determined by the Adviser under the supervision of the Board of
Directors in accordance with regulations of the Securities and Exchange
Commission (the "Commission"), as they may from time to time be amended. For
this purpose, "eligible quality" means a security rated (i) in one of the two
highest rating categories by at least two nationally recognized statistical
rating organizations assigning a rating to the security or issuer; or (ii) if
only one rating organization assigned a rating, by that rating
 
                                       15
<PAGE>
organization; or (iii) if unrated, of comparable quality as determined by the
Board of Directors. The Money Market Portfolio will not purchase any bank or
corporate obligation unless it is rated at least Aa or Prime-1 by Moody's or AA
or A-1 by S&P, or is deemed to be of comparable quality.
 
    These standards must be satisfied at the time an investment is made. In the
event that an investment held by the Portfolio is assigned a lower rating or
ceases to be rated, the Adviser under the supervision of the Board of Directors,
will promptly reassess whether such security presents minimal credit risk and
whether the Portfolio should continue to hold the security. If a portfolio
security no longer presents minimal credit risk or is in default, the Portfolio
will dispose of the security as soon as reasonably practicable unless the Board
of Directors determines that it is not in the best interests of the Portfolio to
do so.
 
THE MUNICIPAL MONEY MARKET PORTFOLIO
 
    The Municipal Money Market Portfolio seeks to maximize current tax-exempt
income and preserve capital while maintaining high levels of liquidity by
investing in the following high quality municipal money market instruments
which, in the opinion of bond counsel for the issuer, earn interest exempt from
federal income tax. The Portfolio will purchase only securities having a
remaining maturity of one year or less. Under normal circumstances, the
Portfolio will invest at least 80% of its assets in tax-exempt municipal
securities. Additionally, the Portfolio will not purchase private activity bonds
that pay interest subject to the alternative minimum tax. Interest on tax-exempt
municipal securities may be subject to state and local taxes. The Portfolio's
average maturity (on a dollar-weighted basis) will not exceed 90 days. The
Portfolio expects to maintain a net asset value of $1.00 per share. There can be
no assurance, however, that the Portfolio will be successful in maintaining a
net asset value of $1.00 per share.
 
    MUNICIPAL BONDS.  The Portfolio may invest in bonds issued by or on behalf
of states, territories and possessions of the United States and its political
subdivisions, agencies, authorities and instrumentalities. These obligations may
be general obligation bonds secured by the issuer's pledge of its full faith,
credit and taxing power for the payment of principal and interest, or they may
be revenue bonds payable from specific revenue sources, but not generally backed
by the issuer's taxing power. These obligations include private activity bonds
where payment is the responsibility of the private industrial user of the
facility financed by the bonds. The Portfolio may invest more than 25% of its
total assets in private activity bonds (provided that the interest on such bonds
is not subject to the alternative minimum tax), but may not invest more than 25%
of its total assets in these bonds related to projects of similar type or in the
same state.
 
    MUNICIPAL NOTES.  The Portfolio may also invest in municipal notes of
various types, including notes issued in anticipation of receipt of taxes, the
proceeds of the sale of bonds, other revenues or grant proceeds and project
notes, as well as municipal commercial paper and municipal demand obligations.
There may be no secondary market for project notes, and the Portfolio intends to
hold such notes until maturity. There is no specific percentage limitation on
these investments.
 
    QUALITY INFORMATION.  The Portfolio will limit its portfolio investments to
those instruments which present minimal credit risk and which are of "eligible
quality" as determined by the Adviser under the supervision of the Board of
Directors in accordance with regulations of the Commission, as they may from
time to time be amended. For this purpose, "eligible quality" means a security
rated (i) in one of the two highest rating categories by at least two nationally
recognized statistical rating organizations assigning a rating to the security
or issuer; or (ii) if only one rating organization assigned a rating, by that
rating organization; or (iii) if unrated, of
 
                                       16
<PAGE>
comparable quality as determined by the Board of Directors. The Municipal Money
Market Portfolio will not purchase any municipal obligation unless it is rated
at least Aa, MIG-1 (or MIG-2 in the case of New York State municipal notes), or
Prime-1 by Moody's, or AA, SP-1 or A-1 by S&P, or is deemed to be of comparable
quality.
 
    These standards must be satisfied at the time an investment is made. In the
event that an investment held by the Portfolio is assigned a lower rating or
ceases to be rated, the Adviser under the supervision of the Board of Directors
will promptly reassess whether such security presents minimal credit risk and
whether the Portfolio should continue to hold the security. If a portfolio
security no longer presents minimal credit risk or is in default, the Portfolio
will dispose of the security as soon as reasonably practicable unless the Board
of Directors determines that it is not in the best interests of the Portfolio to
do so. The credit quality of municipal obligations is frequently enhanced by
various arrangements with domestic or foreign financial institutions, such as
letters of credit, guarantees and insurance, and these arrangements are
considered when investment quality is evaluated.
 
    PUTS FOR THE MUNICIPAL MONEY MARKET PORTFOLIO.  The Portfolio may to the
extent consistent with the Portfolio's investment policies, purchase without
limit municipal bonds or notes together with the right to resell them at an
agreed price or yield within a specified period prior to maturity. This right to
resell is known as a "put." The aggregate price paid for securities with puts
may be higher than the price which otherwise would be paid. The purpose of this
practice is to permit the Portfolio to be fully invested in tax-exempt
securities while maintaining the necessary liquidity to purchase securities on a
when-issued basis, to meet unusually large redemptions, to purchase at a later
date securities other than those subject to the put and to facilitate the
Adviser's ability to manage the Portfolio actively. The principal risk of puts
is that the put writer may default on its obligation to repurchase. The Adviser
will monitor each put writer's ability to meet its obligations. No value is
assigned to any puts. The cost of any such put is carried as an unrealized loss
from the time of purchase until it is exercised or expires.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    FIXED INCOME SECURITIES.  Each Portfolio will invest in fixed income (debt)
securities. The market value of the fixed income securities in which a Portfolio
invest will be affected by changes in the creditworthiness of issuers and will
change in response to interest rate changes and other factors. Generally, the
values of fixed income securities vary inversely with changes in interest rates,
so that during periods of falling interest rates, the values of outstanding
fixed income securities generally rise and during periods of rising interest
rates, the values of such securities generally decline. While securities with
longer maturities tend to produce higher yields, the prices of longer maturity
securities are subject to greater market fluctuations as a result of changes in
interest rates.
 
    FOREIGN INVESTMENT.  The Fixed Income Portfolio may invest in the securities
of foreign issuers. Investment in securities of foreign issuers involves
investment risks somewhat different from those affecting securities of U.S.
issuers. The Portfolio's investments will be subject to political and economic
events that affect the countries in which it invests. Foreign issuers may be
subject to different accounting, auditing and financial standards and
requirements. There also may be less government supervision and regulation of
foreign securities exchanges, brokers and listed companies than in the United
States. Many foreign securities markets have substantially less trading volume
than U.S. national securities exchanges and, therefore, securities of some
 
                                       17
<PAGE>
foreign issuers are less liquid and more volatile than securities of comparable
U.S. issuers. Brokerage commissions and other transaction costs on foreign
securities exchanges are generally higher than in the United States. Dividends
and interest paid by foreign issuers may be subject to withholding and other
foreign taxes, which may decrease the net return on foreign investments as
compared to dividends and interest paid to the Portfolio by domestic companies.
Investments in securities of foreign issuers are generally denominated in
foreign currencies and, since the Portfolio may temporarily hold uninvested
reserves in bank deposits in foreign currencies, the value of the Portfolio's
assets as measured in U.S. dollars may be affected favorably or unfavorably by
changes in currency exchange rates and exchange control regulations, and the
Portfolio may incur costs in connection with conversions between various
currencies.
 
FOREIGN CURRENCY FORWARD CONTRACTS.
 
    Each Non-Money Portfolio may enter into foreign currency forward contracts
("forward contracts") that provide for the purchase or sale of an amount of a
specified currency at a future date. The Portfolio may use such contracts to
protect against a decline in a foreign currency against the U.S. dollar between
the trade date and settlement date when the Portfolio purchases or sells
securities, lock in the U.S. dollar value of dividends and interest on
securities held by the Portfolio, and generally to protect the U.S. dollar value
of securities held by the Portfolio against exchange rate fluctuation. While
forward contracts may limit losses as a result of exchange rate fluctuations,
they will also limit any gains that might otherwise have been realized. The
Portfolio's Custodian may be required to place cash or liquid securities in a
segregated account in an amount equal to the value of the Portfolio's total
assets committed to the consummation of forward contracts. If the value of the
securities placed in the segregated account declines, additional cash or
securities will be placed in the account on a daily basis so that the value of
the account will be at least equal to the amount of the Portfolio's commitments
with respect to such contracts.
 
    LOANS OF PORTFOLIO SECURITIES.  Each Portfolio may lend its securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing net investment income. These loans must be secured
continuously by cash or equivalent collateral or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be risks of delay in recovery of the securities or even loss
of rights in the collateral should the borrower of the securities fail
financially. A Portfolio will not enter into securities loan transactions
exceeding, in the aggregate, 33 1/3% of the market value of the Portfolio's
total assets.
 
    MONEY MARKET INSTRUMENTS.  The Portfolios are permitted to invest in money
market instruments, although each Portfolio intends to stay invested in
securities satisfying its primary investment objective to the extent practical.
Consistent with their investment policies, the Portfolios may make money market
investments pending other investment or settlement for liquidity. In addition,
the Portfolios may invest in money market instruments for temporary defensive
purposes during adverse market conditions. The money market investments
permitted for the Portfolios include obligations of the U.S. Government and its
agencies and instrumentalities, obligations of foreign sovereignties, commercial
paper, bank obligations (including certificates of deposit), other debt
securities and repurchase agreements.
 
    MORTGAGE-BACKED SECURITIES.  The Fixed Income, Mortgage-Backed Securities
and Money Market Portfolios may invest in mortgage-backed securities.
Mortgage-backed securities, directly or indirectly, represent an interest in a
pool of mortgage loans on real property. The Portfolios generally will invest in
two types of
 
                                       18
<PAGE>
mortgage-backed securities. Mortgage pass-through securities represent a direct
interest in a group of loans that has been pooled and the loan payments passed
through to security holders. Collateralized mortgage obligations ("CMOs") are
fixed income securities that, rather than representing a direct interest in a
pool of underlying mortgage loans, are collateralized by the underlying loans.
The indirect ownership structure enables issuers to offer CMOs with a number of
different classes, or tranches, having particular risk/return characteristics.
 
    The loans may be pooled by a government agency or instrumentality, such as
the Government National Mortgage Association, which packages the loans and
guarantees repayment of principal and/or interest on the underlying loans. The
agencies or instrumentalities pooling and guaranteeing such loans may or may not
be backed by full faith and credit of the U.S. Government. Mortgage-backed
securities also may be issued by private originators of or investors in mortgage
loans and structured similarly to governmental pass-through securities. Because
privately issued securities typically lack a guarantee by an entity having the
credit status of a governmental agency or instrumentality, they often are
structured with one or more types of credit enhancement.
 
    Investment in mortgage-backed securities entails certain risks. Like other
debt securities, the value of mortgage-backed securities generally varies
inversely with changes in interest rates. However, mortgage-backed securities
may respond to these changes in a manner different from other fixed income
securities because the possibility of prepayment of the underlying mortgage
loans makes it difficult to determine in advance the actual maturity date or
average life of a mortgage-backed security. Rising interest rates tend to
discourage refinancings, with the result that the average life and volatility of
the security will increase and its market price will decrease. When interest
rates fall, however, mortgage-backed securities may not gain as much in value
because increased mortgage prepayments must be reinvested at lower interest
rates.
 
    REPURCHASE AGREEMENTS.  Each Portfolio may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines of the Fund's
Board of Directors. In a repurchase agreement, a Portfolio buys a security from
a seller that has agreed to repurchase it at a mutually agreed upon date and
price, reflecting the interest rate effective for the term of the agreement. The
term of these agreements is usually from overnight to one week and never exceeds
one year. A repurchase agreement may be viewed as a fully collateralized loan of
money by the Portfolio to the seller. The Portfolio always receives securities
with a market value at least equal to the purchase price (including accrued
interest) as collateral, and this value is maintained during the term of the
agreement. If the seller defaults and the collateral value declines, the
Portfolio might incur a loss. If bankruptcy proceedings are commenced with
respect to the seller, the Portfolio's realization upon the collateral may be
delayed or limited. The Portfolio may not enter into repurchase agreements with
more than seven days to maturity if, as a result, more than 15% of the market
value of the Portfolio's net assets are invested in these agreements and other
investments for which market quotations are not readily available or which are
otherwise illiquid.
 
    REVERSE REPURCHASE AGREEMENTS.  The Money Market Portfolio may enter into
reverse repurchase agreements with brokers, dealers, domestic and foreign banks
or other financial institutions. In a reverse repurchase agreement, the
Portfolio sells a security and agrees to repurchase it at a mutually agreed upon
date and price, reflecting the interest rate effective for the term of the
agreement. Reverse Repurchase Agreements may also be viewed as the borrowing of
money by the Portfolio and are, therefore, subject to the Portfolio's overall
borrowing limitations. The Portfolio's investment of the proceeds of a reverse
repurchase agreement is the speculative factor known as leverage. The Portfolio
may enter into a reverse repurchase agreement only if
 
                                       19
<PAGE>
the interest income from investment of the proceeds is greater than the interest
expense of the transaction and the proceeds are invested for a period no longer
than the term of the agreement. The Portfolio will maintain with the Custodian a
segregated account of securities at least equal to its purchase obligations
under these agreements. If interest rates rise during a reverse repurchase
agreement, it may adversely affect the Portfolio's ability to maintain a stable
net asset value.
 
    TAXABLE INVESTMENTS.  The Municipal Bond and Municipal Money Market
Portfolios attempt to invest 80% and 100%, respectively, of their assets in
tax-exempt municipal securities. However, the Portfolios are permitted to invest
up to 20% of the value of their total assets in securities, the interest income
of which is subject to federal income tax. Either Portfolio may make taxable
investments pending investment of proceeds from sales of its shares or portfolio
securities or pending settlement of purchases of portfolio securities in order
to maintain liquidity to meet redemptions or when it is advisable in the
Adviser's opinion because of adverse market conditions. The taxable investments
permitted for either Portfolio include obligations of the U.S. Government and
its agencies and instrumentalities, bank obligations, commercial paper and
repurchase agreements. Fees from loans of tax-exempt securities will also be
taxable income of the Portfolio.
 
    TEMPORARY INVESTMENTS.  During periods in which the Adviser believes changes
in economic, financial or political conditions make it advisable, each Portfolio
may, for temporary defensive purposes, invest up to 100% of its total assets in
certain short-term and medium-term debt obligations or hold cash. The short-term
and medium-term debt obligations in which a Portfolio may invest consist of (i)
obligations of the U.S. or foreign governments, their respective agencies or
instrumentalities; (ii) money market instruments; and (iii) instruments
denominated in any currency issued by international development agencies.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  Each Portfolio may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Delivery of and payment for these securities may take
as long as a month or more after the date of the purchase commitment but will
take place no more than 120 days after the trade date. Each Portfolio will
maintain with the Custodian a segregated account of cash or liquid securities in
an amount at least equal to these commitments. The payment obligation and the
interest rates that will be received are each fixed at the time a Portfolio
enters into the commitment and no interest accrues to the Portfolio until
settlement. Thus, it is possible that the market value at the time of settlement
could be higher or lower than the purchase price if the general level of
interest rates has changed. It is a fundamental policy of the Money Market
Portfolio and a current policy of the Municipal Money Market Portfolio not to
enter into when-issued commitments exceeding, in the aggregate, 15% of the
market value of the Portfolio's total assets less liabilities other than the
obligations created by these commitments.
 
DERIVATIVE PRODUCTS (DERIVATIVES)
 
    The Non-Money Portfolios are permitted to utilize various exchange-traded
and over-the-counter derivative instruments and derivative securities, both for
hedging and non-hedging purposes. The Money Portfolios do not utilize derivative
products. Permitted derivative products include, but are not limited to: futures
contracts ("futures"); forward contracts ("forwards"); options; swaps, caps,
collars and floors; structured notes; and other derivative products yet to be
developed, so long as these new products are used in a manner consistent with
the objectives of the Portfolios. These derivative products may be based upon a
wide variety of underlying rates,
 
                                       20
<PAGE>
indices, instruments, securities and other products, such as interest rates,
foreign currencies, foreign and domestic fixed income and equity securities,
groups or "baskets" of securities and securities indices (for each derivative
product, the "underlying"). Exclusive of forward foreign currency contracts and
any derivative products used for hedging purposes, each Portfolio will limit its
use of derivative products to 33 1/3% of its total assets, measured by the
aggregate notional amount of outstanding derivative products.
 
    The Portfolios may use derivative products under a number of different
circumstances to further their investment objectives. For example, a Portfolio
may purchase derivatives to gain exposure to a market quickly in response to
changes in the Portfolio's investment strategy, upon the inflow of investable
cash or when the derivative provides greater liquidity than the underlying
market. A Portfolio may also use derivatives when it is restricted from directly
owning the "underlying" or when derivatives provide a pricing advantage or lower
transaction costs. The Portfolios also may purchase combinations of derivatives
in order to gain exposure to an investment in lieu of actually purchasing such
investment. Derivatives may also be used by a Portfolio for hedging or risk
management purposes and in other circumstances when the Adviser believes it
advantageous to do so consistent with the Portfolio's investment objectives and
policies. The Portfolios will not use derivatives in a manner that creates
leverage, except to the extent that the use of leverage is expressly permitted
by a particular Portfolio's investment policies, and then only in a manner
consistent with such policies.
 
    The use of derivative products is a highly specialized activity which
involves investment techniques and risks different from those associated with
ordinary portfolio securities transactions. If the Adviser is incorrect in
forecasts of market values, interest rates, and currency exchange rates, the
investment performance of the Portfolios will be less favorable than it would
have been if these investment techniques had not been used.
 
    Some of the derivative products in which the Portfolios may invest and some
of the risks related thereto are described in more detail below.
 
FUTURES CONTRACTS (FUTURES) AND FORWARD CONTRACTS (FORWARDS)
 
    The Non-Money Portfolios may purchase and sell futures contracts, such as
futures on securities indices, baskets of securities, foreign currencies and
interest rates of the type generally known as financial futures. These are
standardized contracts that are bought and sold on organized exchanges. A
futures contract obligates a party to buy or sell a specific amount of the
"underlying," such as for example, a particular foreign currency, on a specified
future date at a specified price or to settle the value in cash.
 
    The Portfolios may also purchase and sell forward contracts, such as forward
rate agreements and other financial forward contracts. The Portfolios may also
use foreign currency forward contracts which are separately discussed elsewhere
in this Prospectus. See "Foreign Currency Forward Contracts" above. These
forward contracts are privately negotiated and are bought and sold in the
over-the-counter market. Like a future, a forward contract obligates a party to
buy or sell a specific amount of the underlying on a specified future date at a
specified price. The terms of the forward contract are customized. Forward
contracts, like other over-the-counter contracts that are negotiated directly
with an individual counterparty, subject the Portfolio to the risk of
counterparty default.
 
                                       21
<PAGE>
    In some cases, the Portfolios may be able to use either futures contracts,
forward contracts or exchange-traded or over-the-counter options to accomplish
similar purposes. In all cases, the Portfolios will use these products only as
permitted by applicable laws and regulations. Some of the ways in which the
Portfolios may utilize futures contracts, forward contracts and related options
are as follows:
 
    The Portfolios may sell securities index futures contracts and/or index
options thereon in anticipation of or during a market decline to attempt to
offset the decrease in market value of investments in its portfolio, or may
purchase securities index futures or options in order to gain market exposure.
There currently are limited securities index futures and options on such futures
in many countries, particularly emerging countries. The nature of the strategies
adopted by the Adviser, and the extent to which those strategies are used, may
depend on the development of such markets. The Portfolios may also purchase and
sell foreign currency futures to hedge their respective holdings and commitments
against changes in the level of future currency rates or to adjust their
exposure to a particular currency.
 
    The Portfolios may engage in transactions in interest rate futures and
related products. The value of these contracts rises and falls inversely with
changes in interest rates. The Portfolios may engage in such transactions to
hedge their holdings of debt instruments against future changes in interest
rates or for other purposes.
 
    The Portfolios may also purchase or sell futures and forwards on other
financial instruments, such as U.S. Government securities and certificates of
deposit. The value of these contracts also rises and falls inversely with
changes in interest rates. The Portfolios may engage in financial futures and
forward contracts for both hedging and non-hedging purposes.
 
    Gains and losses on futures contracts, forward contracts and related options
depend on the Adviser's ability to predict correctly the direction of securities
prices, interest rates and other economic factors. Other risks associated with
the use of these instruments include (i) imperfect correlation between the
change in market value of investments held by a Portfolio and the prices of
derivative products relating to investments purchased or sold by the Portfolio,
and (ii) possible lack of a liquid secondary market for a derivative product and
the resulting inability to close out a position. The risk that a Portfolio will
be unable to close out a position will be minimized by only entering into
transactions for which there appears to be a liquid exchange or secondary
market. In some strategies, the risk of loss in trading on futures and related
transactions can be substantial, due both to the low margin deposits required
and the extremely high degree of leverage involved in pricing.
 
    Under rules adopted by the Commodity Futures Trading Commission (the
"CFTC"), each Portfolio may, without registering with the CFTC as a Commodity
Pool Operator, enter into futures contracts and options thereon for both hedging
and non-hedging purposes, provided that not more than 5% of such Portfolio's
total assets at the time of entering the transaction are required as margin and
option premiums to secure obligations under such contracts relating to non-bona
fide hedging activities.
 
OPTION TRANSACTIONS
 
    The Non-Money Portfolios may seek to increase their returns or may hedge
their portfolio investments through options transactions with respect to
individual securities, indices or baskets in which such Portfolios may invest;
other financial instruments; and foreign currency. Various options may be
purchased and sold on either the exchange-traded or over-the-counter markets.
 
                                       22
<PAGE>
    Each Portfolio may purchase put and call options. Purchasing a put option
gives a Portfolio the right, but not the obligation, to sell the underlying
(such as a securities index or a particular foreign currency) at the exercise
price either on a specific date or during a specified exercise period.
Purchasing a call option gives a Portfolio a similar right, but not the
obligation, to purchase the underlying. The purchaser pays a premium to the
seller (also known as the writer) of the option.
 
    Each Portfolio also may write put and call options on investments held in
its portfolio, as well as foreign currency options. A Portfolio that has written
an option receives a premium that increases the Portfolio's return on the
underlying in the event the option expires unexercised or is closed out at a
profit. However, by writing a call option, a Portfolio will limit its
opportunity to profit from an increase in the market value of the underlying
above the exercise price of the option. By writing a put option, a Portfolio
will be exposed to the amount by which the price of the underlying is less than
the strike price.
 
    By writing an option, a Portfolio incurs an obligation either to buy (in the
case of a put option) or sell (in the case of a call option) the underlying from
the purchaser of the option at the option's exercise price, upon exercise by the
purchaser. Pursuant to guidelines established by the Board of Directors, the
Portfolios may only write options that are "covered." A covered call option
means that until the expiration of the option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will continue to own (i) the underlying; (ii) securities or instruments
convertible or exchangeable without the payment of any consideration into the
underlying; or (iii) a call option on the same underlying with a strike price no
higher than the price at which the underlying was sold pursuant to a short
option position. In the case of a put option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will own another put option on the same underlying with an equal or higher
strike price.
 
    There currently are limited options markets in many countries, particularly
emerging market countries, and the nature of the strategies adopted by the
Adviser and the extent to which those strategies are used will depend on the
development of these options markets. The primary risks associated with the
Portfolios' use of options as described include (i) imperfect correlation
between the change in market value of investments held, purchased or sold by a
Portfolio and the prices of options relating to such investments, and (ii)
possible lack of a liquid secondary market for an option.
 
INTEREST RATE, CURRENCY, COMMODITY AND EQUITY SWAPS, CAPS, COLLARS AND FLOORS
 
    Swaps are privately negotiated over-the-counter derivative products in which
two parties agree to exchange payment streams calculated in relation to a rate,
index, instrument or certain securities and a particular "notional amount." As
with many of the other derivative products available to the Non-Money
Portfolios, the underlying may include an interest rate (fixed or floating), a
currency exchange rate, a commodity price index, and a security, securities
index or a combination thereof. A great deal of flexibility is possible in the
way the products may be structured, with the effect being that the parties may
have exchanged amounts equal to the return on one rate, index or group of
securities for another. For example, in a simple fixed-to-floating interest rate
swap, one party makes payments equivalent to a fixed interest rate, and the
other makes payments equivalent to a specified interest rate index. A Portfolio
may engage in simple or more complex swap transactions involving a wide variety
of underlyings. The currency swaps that the Portfolios may enter will generally
involve an
 
                                       23
<PAGE>
agreement to pay interest streams in one currency based on a specified index in
exchange for receiving interest streams denominated in another currency. Such
swaps may involve initial and final exchanges that correspond to the agreed upon
notional amount.
 
    Caps, collars and floors are privately-negotiated option-based derivative
products. A Portfolio may use one or more of these products in addition to or in
lieu of a swap involving a similar rate or index. As in the case of a put or
call option, the buyer of a cap or floor pays a premium to the writer. In
exchange for that premium, the buyer receives the right to a payment equal to
the differential if the specified index or rate rises above (in the case of a
cap) or falls below (in the case of a floor) a pre-determined strike level. As
in the case of swaps, obligations under caps and floors are calculated based
upon an agreed notional amount, and like most swaps (other than foreign currency
swaps), the entire notional amount is not exchanged and thus is not at risk. A
collar is a combination product in which the same party, such as the Portfolio,
buys a cap from and sells a floor to the other party. As with put and call
options, the amount at risk is limited for the buyer, but, if the cap or floor
is not hedged or covered, may be unlimited for the seller. Under current market
practice, caps, collars and floors between the same two parties are generally
documented under the same "master agreement." In some cases, options and forward
agreements may also be governed by the same master agreement. In the event of a
default, amounts owed under all transactions entered into under, or covered by,
the same master agreement would be netted and only a single payment would be
made.
 
    Swaps, caps, collars and floors are credit-intensive products. A Portfolio
that enters into a swap transaction bears the risk of default, i.e. nonpayment,
by the other party. The guidelines under which each Portfolio enters derivative
transactions, along with some features of the transactions themselves, are
intended to reduce these risks to the extent reasonably practicable, although
they cannot eliminate the risks entirely. Under guidelines established by the
Board of Directors, a Portfolio may enter into swaps only with parties that meet
certain credit rating guidelines. Consistent with current market practices, a
Portfolio will generally enter into swap transactions on a net basis, and all
swap transactions with the same party will be documented under a single master
agreement to provide for net payment upon default. In addition, a Portfolio's
obligations under an agreement will be accrued daily (offset against any amounts
owing to the Portfolio) and any accrued, but unpaid, net amounts owed to the
other party to a master agreement will be covered by the maintenance of a
segregated account consisting of cash or liquid securities.
 
    Interest rate and total rate of return (fixed income or equity) swaps
generally do not involve the delivery of securities, other underlying assets, or
principal. In such case, if the other party to an interest rate or total rate of
return swap defaults, a Portfolio's risk of loss will consist of the payments
that a Portfolio is contractually entitled to receive from the other party. This
may not be true for currency swaps that require the delivery of the entire
notional amount of one designated currency in exchange for the other. If there
is a default by the other party, a Portfolio may have contractual remedies
pursuant to the agreements related to the transaction.
 
STRUCTURED NOTES
 
    Structured notes are derivative securities for which the amount of principal
repayment and/or interest payments is based upon the movement of one or more
factors. These factors include, but are not limited to, currency exchange rates,
interest rates (such as the prime lending rate and LIBOR) and stock indices,
such as
 
                                       24
<PAGE>
the S&P 500. In some cases, the impact of the movements of these factors may
increase or decrease through the use of multipliers or deflators. The Non-Money
Portfolios may use structured notes to tailor their investments to the specific
risks and returns the Adviser wishes to accept while avoiding or reducing
certain other risks.
 
                             INVESTMENT LIMITATIONS
 
    Each Portfolio is a diversified investment company under the Investment
Company Act of 1940, as amended (the "1940 Act") and is subject to the following
limitations: (i) as to 75% of its total assets, a Portfolio may not invest more
than 5% of its total assets in the securities of any one issuer, except
obligations of the U.S. Government and its agencies and instrumentalities; and
(ii) a Portfolio may not own more than 10% of the outstanding voting securities
of any one issuer.
 
    Each Portfolio also operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of the
holders of a majority of such Portfolio's outstanding shares and under certain
non-fundamental investment limitations that may be changed without shareholder
approval. For additional information on fundamental and non-fundamental
investment limitations, see "Investment Limitations" in the Statement of
Additional Information.
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and each Portfolio. The Adviser provides investment
advice and portfolio management services pursuant to an Investment Advisory
Agreement and, subject to the supervision of the Fund's Board of Directors,
makes the portfolio's day-to-day investment decisions, arranges for the
execution of portfolio transactions and generally manages the Portfolio's
investments. Set forth below as an annual percentage of daily net assets are the
management fees payable to the Adviser quarterly by each Portfolio pursuant to
the terms of the Investment Advisory Agreement. The Adviser has voluntarily
agreed to a reduction in the fees payable to it and to reimburse the Non-Money
Portfolios, if necessary, if such fees would cause the total annual operating
expenses of any Portfolio to exceed the maximum set forth in the table below.
 
<TABLE>
<CAPTION>
                                                                       MAXIMUM TOTAL OPERATING EXPENSES
                                                                              AFTER FEE WAIVERS
                                                MANAGEMENT FEE     ----------------------------------------
PORTFOLIO                                     ABSENT FEE WAIVERS         CLASS A              CLASS B
- --------------------------------------------  -------------------  -------------------  -------------------
<S>                                           <C>                  <C>                  <C>
Fixed Income                                           0.35%                0.45%                0.60%
Municipal Bond                                         0.35%                0.45%                0.70%
Mortgage-Backed Securities                             0.35%                0.45%                0.70%
Money Market                                           0.30%                0.55%                0.80%
Municipal Money Market                                 0.30%                0.57%               N/A
</TABLE>
 
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to customers in the
United States and abroad. Morgan Stanley Dean Witter & Co. ("MSDW") is the
direct parent of the Adviser and Morgan Stanley. MSDW is a preeminent global
financial services firm that maintains leading market positions in each of its
three primary businesses -- securities, asset management and credit services. At
 
                                       25
<PAGE>
March 31, 1998, the Adviser, together with its affiliated institutional asset
management companies, managed assets of approximately $166 billion, including
assets under fiduciary advice. See "Management of the Fund" in the Statement of
Additional Information.
 
    PORTFOLIO MANAGERS.  The following individuals have primary portfolio
management responsibility for the Portfolios noted below:
 
    FIXED INCOME PORTFOLIO  --  WARREN ACKERMAN, III. Warren Ackerman is a
Principal of the Adviser and Morgan Stanley and a Senior Fixed Income Portfolio
Manager. Mr. Ackerman joined the Advisor in December 1993. Prior to joining the
Advisor, Mr. Ackerman spent over 14 years with Bankers Trust Company as a
Managing Director responsible for institutional active fixed income management.
Prior to Bankers, he spent almost seven years as a Vice President with Irving
Trust Company in the Trust Investment Division. Mr. Ackerman is a graduate of
Monmouth College with a B.S. in Economics. Mr. Ackerman has had primary
responsibility for managing the Portfolio's assets since March 1994.
 
    MUNICIPAL BOND PORTFOLIO  --  LORI A. COHANE. Lori A. Cohane joined the
Adviser in 1994 as a Vice President and Municipal Bond Portfolio Manager. Prior
to joining the Adviser, Ms. Cohane spent eight years with Salomon Brothers Asset
Management as a Vice President, Portfolio Manager and Senior Credit Analyst of
municipal bond accounts managing portfolios for high net worth individuals,
open- and closed-end bond funds and institutional accounts. Ms. Cohane is a
magna cum laude graduate of the State University of New York at Albany with a
B.S. degree in Finance and Economics. Ms. Cohane has had primary responsibility
for managing the Portfolio's assets since its inception.
 
    MORTGAGE-BACKED SECURITIES PORTFOLIO  --  WARREN ACKERMAN, III. Information
about Mr. Ackerman is included under Fixed Income Portfolio above. Mr. Ackerman
has had primary responsibility for managing the Portfolio's assets since its
inception.
 
    MONEY MARKET PORTFOLIO  --  ABIGAIL JONES FEDER AND DANIEL M. NILAND.
Abigail Jones Feder is a Principal of the Adviser and Morgan Stanley and shares
responsibility for managing short-term taxable and tax-exempt portfolios. Ms.
Feder joined Morgan Stanley's Corporate Finance Department in 1985. In 1987 she
joined the Adviser as a Marketing Analyst and was promoted to a Marketing
Director in 1988. She joined the Fixed Income Group as a Portfolio Manager in
1989 and she became a Vice President in 1992. Ms. Feder holds a B.A. from Vassar
College. Ms. Feder has had primary responsibility for managing the portfolio's
assets since its inception. Daniel M. Niland joined the Adviser in July 1997 as
a Vice President and shares responsibility for managing short-term taxable
portfolios. Prior to joining the Adviser, Mr. Niland managed liquidity and short
duration fixed income portfolios for institutional and private accounts at
Citibank Global Asset Management from January 1996 to June 1997. Before joining
Citibank, Mr. Niland worked at J.P. Morgan from April 1991 to January 1996 as a
portfolio manager investing $20 billion in short-term securities for that firm's
securities lending program. Mr. Niland holds a B.A. from Iona College and an
M.B.A. from Fordham University. Mr. Niland has shared primary responsibility for
managing the Portfolio's assets since July 1997.
 
    MUNICIPAL MONEY MARKET PORTFOLIO  --  ABIGAIL JONES FEDER. Information about
Ms. Feder is included under the Money Market Portfolio above. Ms. Feder has had
primary responsibility for managing the Portfolio's assets since its inception.
 
                                       26
<PAGE>
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the officers and the
Board of Directors of the Fund, and include day-to-day administration of matters
related to the corporate existence of the Fund, maintenance of its records,
preparation of reports, supervision of the Fund's arrangements with its
custodian and assistance in the preparation of the Fund's registration
statements under federal laws. The Administration Agreement also provides that
the Administrator through its agents will provide dividend disbursing and
transfer agent services to the Fund. For its services under the Administration
Agreement, the Fund pays the Adviser a monthly fee which on an annual basis
equals 0.15% of the average daily net assets of each Portfolio.
 
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors such administrative services provided by CGFSC.
Their services are also subject to the supervision of the Board of Directors of
the Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of each Portfolio upon the terms and at the current
offering price described in this Prospectus. Morgan Stanley is not obligated to
sell any certain number of shares of any Portfolio.
 
    The Portfolios currently offer only the classes of shares offered by this
Prospectus. The Portfolios may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares of each of the Non-Money Portfolios and the Money Market Portfolio
pursuant to Rule 12b-1 under the 1940 Act (each, a "Plan"). Under each Plan, the
Distributor is entitled to receive from each of the Non-Money Portfolios and the
Money Market Portfolio a distribution fee, which is accrued daily and paid
quarterly, of 0.25% of the Class B shares' average daily net assets on an
annualized basis. Each Plan is designed to compensate the Distributor for its
services in connection with distribution assistance. The Distributor may retain
any portion of the fee that it does not expend in meeting its obligations to the
Fund. The Distributor may compensate financial intermediaries, plan fiduciaries
and administrators for providing distribution-related services, including
account maintenance services, to shareholders (including, where applicable,
underlying beneficial owners) of Class B shares. The Distributor has agreed to
waive 0.10% of the 0.25% distribution fee it is entitled to receive from the
Fixed Income Portfolio.
 
    EXPENSES.  Each Portfolio is responsible for payment of certain other fees
and expenses (including legal fees, accountant's fees, custodial fees and
printing and mailing costs) as specified in its agreements with the Adviser and
Morgan Stanley.
 
    YEAR 2000.  The management and distribution services provided to the Fund by
the Adviser and Morgan Stanley depend on the smooth functioning of their
computer systems. Many computer software systems in use
 
                                       27
<PAGE>
today cannot recognize the year 2000, but revert to 1900 or some other date, due
to the manner in which dates were encoded and calculated. That failure could
have a negative impact on the handling of securities trades, pricing and account
services. The Adviser and Morgan Stanley have been actively working on necessary
changes to their own computer systems to deal with the year 2000 problem and
expect that their systems will be adapted before that date. There can be no
assurance, however, that they will be successful. In addition, other
unaffiliated service providers may be faced with similar problems. The Adviser
and Morgan Stanley are monitoring their remedial efforts, however, there can be
no assurance that they and the services they provide will not be adversely
affected.
 
    In addition, it is possible that the markets for securities in which the
Portfolios invest may be detrimentally affected by computer failures throughout
the financial services industry beginning January 1, 2000. Improperly
functioning trading systems may result in settlement problems and liquidity
issues. In addition, corporate and governmental data processing errors may
result in production problems for individual companies and overall economic
uncertainties. Earnings of individual issuers will be affected by remediation
costs, which may be substantial and may be reported inconsistently in U.S. and
foreign financial statements. Accordingly, the Portfolios' investments may be
adversely affected.
 
                               PURCHASE OF SHARES
 
    Class A shares of each Portfolio and Class B shares of each Portfolio except
the Municipal Money Market Portfolio may be purchased at the net asset value per
share next determined after receipt by the Fund of a purchase order as described
under "Methods of Purchase." CLASS B SHARES OF THE MONEY MARKET PORTFOLIO ARE
AVAILABLE FOR PURCHASE ONLY THROUGH FINANCIAL INTERMEDIARIES (AS DISCUSSED
BELOW) THAT HAVE MADE ARRANGEMENTS WITH THE FUND. The net asset value per share
of each Portfolio is calculated on days that the New York Stock Exchange
("NYSE") and Chase (the "Custodian Bank") are open for business. Net asset value
per share is determined (i) for each Non-Money Portfolio, as of the close of
trading of the NYSE (normally 4:00 p.m. Eastern Time); (ii) for the Money Market
Portfolio, as of 12:00 noon Eastern Time; and (iii) for the Municipal Money
Market Portfolio, as of 11:00 a.m. Eastern Time (for each Portfolio, the
"Pricing Time").
 
MINIMUM INVESTMENT
 
    The minimum initial investment is $500,000 for Class A shares and $100,000
for Class B shares of each Non-Money Portfolio. The minimum initial investment
is $100,000 for Class A shares of each Money Portfolio. There is no minimum
initial investment for Class B shares of the Money Market Portfolio. These
minimums may be waived at the discretion of the Adviser for certain types of
investors, including trust departments, brokers, dealers, agents, financial
planners, financial services firms, investment advisers or various retirement
and deferred compensation plans ("Financial Intermediaries"); certain accounts
managed by the Adviser and its affiliates ("Managed Accounts"); and certain
employees and customers of Morgan Stanley and its affiliates. The Fund's
determination of an investor's eligibility to purchase shares of a given class
will take precedence over the investor's selection of a class.
 
METHODS OF PURCHASE
 
    Shares may be purchased directly from the Fund by Federal Funds wire, by
bank wire or by check. Investors may also invest in the Portfolios by purchasing
shares through Financial Intermediaries that have made arrangements with Morgan
Stanley. Class B shares of the Money Market Portfolio may be purchased only
 
                                       28
<PAGE>
through Financial Intermediaries. Some Financial Intermediaries may charge an
additional service or transaction fee. If a purchase is canceled due to
nonpayment or because your check does not clear, you will be responsible for any
loss the Fund or its agents incur. If you are already a shareholder, the Fund
may redeem shares from your account(s) to reimburse the Fund or its agents for
any loss. In addition, you may be prohibited or restricted from making future
investments in the Fund.
 
    FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire Federal
Funds to the Fund's bank account. Federal Funds purchase orders will be accepted
only on a day on which the Fund and the Custodian Bank are open for business.
Your bank may charge a service fee for wiring Federal Funds. In order to ensure
proper handling of your purchase by Federal Funds wire, please follow these
steps:
 
    1. Place your order by telephoning the Fund at 1-800-548-7786. A Fund
       representative will request certain purchase information and provide you
       with a confirmation number.
 
    2. Instruct your bank to wire the specified amount to the Fund's Wire
       Concentration Bank Account as follows:
 
            The Chase Manhattan Bank
           One Manhattan Plaza
           New York, NY 10081-1000
           ABA# 021000021
           DDA# 910-2-733293
           Attn: Morgan Stanley Institutional Fund, Inc.
           Ref: (Portfolio name, your account number, your account name)
           Please call the Fund at 1-800-548-7786 prior to wiring funds.
 
    3. Complete and sign the Account Registration Form and mail it to the
       address shown thereon.
 
    When a purchase order is received prior to the Pricing Time and Federal
Funds are received prior to the regular close of the Federal Funds Wire Control
Center ("FFWCC") (normally 6:00 p.m. Eastern Time) the purchase will be executed
at the net asset value computed on the date of receipt. Purchases for which an
order is received after the Pricing Time or for which Federal Funds are received
after the regular close of the FFWCC will be executed at the net asset value
next determined. Certain institutional investors and financial institutions have
entered into an agreement with Morgan Stanley pursuant to which they may place
orders prior to the Pricing Time, but make payment in Federal Funds for those
shares the following business day.
 
    BANK WIRE.  A purchase of shares by bank wire must follow the same procedure
as for a Federal Funds wire, described above. However, depending on the time the
bank wire is sent and the bank handling the wire, money transferred by bank wire
may or may not be converted into Federal Funds prior to the close of the FFWCC.
Prior to conversion to Federal Funds and receipt by the Fund, an investor's
money will not be invested.
 
    CHECK.  An account may be opened by completing and signing an Account
Registration Form and mailing it, together with a check payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio name]" to:
 
            Morgan Stanley Institutional Fund, Inc.
           P.O. Box 2798
           Boston, Massachusetts 02208-2798
 
                                       29
<PAGE>
    The Fund ordinarily is credited with Federal Funds within one business day
of deposit of a check. Thus, a purchase of shares by check ordinarily will be
credited to your account at the net asset value per share of each of the
Portfolios determined on the next business day after receipt. An investor's
money will not be invested prior to crediting of Federal Funds.
 
    INVESTMENT THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to receive purchase and
redemption orders from underlying beneficial owners, such as retirement plan
participants, generally on each business day. Each business evening, the
Financial Intermediary aggregates all orders received from underlying beneficial
owners prior to the Pricing Time on that business day, and places a net purchase
and/or redemption order(s) by the morning of the next business day. These orders
normally are executed at the net asset value that was computed for each
Portfolio as of the close of the previous business day.
 
    ADDITIONAL INVESTMENTS.  You may purchase additional shares for your account
at any time by purchasing shares at net asset value by any of the methods
described above. The minimum additional investment generally is $1,000 per
Portfolio, except that there is no minimum for Class B shares of the Money
Market Portfolio. The minimum additional investment may be lower for certain
accounts described above under "Minimum Investment." For purchases directly from
the Fund, your account name, the Portfolio name and the class selected must be
specified in the letter or wire to assure proper crediting to your account.
 
INVOLUNTARY CONVERSION AND REDEMPTION OF NEW ACCOUNT SHARES
 
    Class A and Class B shares of each Non-Money Portfolio may be subject to the
involuntary conversion and redemption features described below. Shares of the
Money Portfolios are not subject to involuntary conversion or redemption. The
conversion and redemption features may be waived at the discretion of the
Adviser for shares held in a Managed Account and shares purchased through a
Financial Intermediary. Accounts that were open prior to January 2, 1996 are not
subject to involuntary conversion or redemption. The Fund reserves the right to
modify or terminate the conversion or redemption features of the shares at any
time upon 60 days notice to shareholders.
 
    CONVERSION FROM CLASS A TO CLASS B SHARES.  If the value of an account
containing Class A shares of a Non-Money Portfolio falls below $500,000 (but
remains at or above $100,000) because of shareholder redemption(s), the Fund
will notify the shareholder, and if the account value remains below $500,000
(but remains at or above $100,000) for a continuous 60-day period, the Class A
shares in such account will convert to Class B shares and will be subject to the
distribution fee and other features applicable to Class B shares. The Fund will
not convert Class A shares of a Non-Money Portfolio to Class B shares based
solely upon changes in the market that reduce the net asset value of shares.
Under current tax law, conversion between share classes is not a taxable event
to the shareholder.
 
    CONVERSION FROM CLASS B TO CLASS A SHARES.  If the value of an account
containing Class B shares of a Non-Money Portfolio increases to $500,000 or
more, whether due to shareholder purchases or market activity, the Class B
shares will convert to Class A shares. Class B shares purchased through a
Financial Intermediary that has entered into an arrangement with the Fund for
the purchase of such shares may not be converted. Under current tax law, such
conversion is not a taxable event to the shareholder. Class A shares converted
from Class B shares are subject to the same minimum account size requirements as
are applicable to accounts containing Class A shares described above.
 
                                       30
<PAGE>
    INVOLUNTARY REDEMPTION OF SHARES.  If the value of an account falls below
$100,000 because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $100,000 for a continuous
60-day period, the shares in such account will be subject to redemption by the
Fund. The Fund will not redeem shares based solely upon changes in the market
that reduce the net asset value of shares. If redeemed, redemption proceeds will
be promptly paid to the shareholder.
 
                              REDEMPTION OF SHARES
 
    Class A shares of each Portfolio and Class B shares of each Portfolio except
the Municipal Money Market Portfolio may be redeemed at any time and without
charge at the net asset value per share next determined after receipt by the
Fund of a redemption order as described under "Methods of Redemption."
Redemption proceeds may be more or less than the purchase price of your shares
depending on, among other factors, the market value of the investment securities
held by a Portfolio.
 
METHODS OF REDEMPTION
 
    Shares may be redeemed directly from the Fund by mail or by telephone.
HOWEVER, SHARES PURCHASED THROUGH A FINANCIAL INTERMEDIARY MUST BE REDEEMED
THROUGH A FINANCIAL INTERMEDIARY. Certain Financial Intermediaries may charge an
additional service or transaction fee.
 
    BY MAIL.  Each Portfolio will redeem shares upon receipt of a redemption
request in "good order." Redemption requests may be sent by regular mail to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798 or, by overnight courier, to Morgan Stanley Institutional Fund, Inc.,
c/o Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913.
 
    "Good order" means that the request to redeem shares must include the
following:
 
    1. A letter of instruction or a stock assignment specifying the class and
       number of shares or dollar amount to be redeemed, signed by all
       registered owners of the shares in the exact names in which they are
       registered;
 
    2. Any required signature guarantees; and
 
    3. Other supporting legal documents, if required, in the case of estates,
       trusts, guardianships, custodianships, corporations, pension and
       profit-sharing plans and other organizations.
 
    Redemption requests received in "good order" prior to the Pricing Time will
be executed at the net asset value computed on the date of receipt. Redemption
requests received after the Pricing Time will be executed at the next determined
net asset value. Shareholders who are uncertain of requirements for redemption
by mail should consult with a Fund representative.
 
    BY TELEPHONE.  If you have previously elected the Telephone Redemption
Option on the Account Registration Form, you can redeem Portfolio shares by
calling the Fund and requesting that the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. To change the commercial bank or account designated to receive
redemption proceeds, send a written request to the Fund at the address above.
Requests to change the bank or account must be signed by each shareholder and
 
                                       31
<PAGE>
each signature must be guaranteed. The telephone redemption option may be
difficult to implement at times, particularly during volatile market conditions.
If you experience difficulty in making a telephone redemption, you may redeem
shares by mail as described above.
 
    The Fund and the Transfer Agent will employ reasonable procedures to confirm
that instructions communicated by telephone are genuine. These procedures
include requiring the investor to provide certain personal identification
information at the time an account is opened and prior to effecting each
telephone transaction. In addition, all telephone transaction requests will be
recorded and investors may be required to provide additional telecopied written
instructions regarding transaction requests. Neither the Fund nor the Transfer
Agent will be responsible for any loss, liability, cost or expense for following
instructions received by telephone that either of them reasonably believes to be
genuine.
 
    REDEMPTION THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to accept redemption
requests from underlying beneficial owners. These redemptions may be processed
in the same way as purchases made through such Financial Intermediaries, as
described above.
 
FURTHER REDEMPTION INFORMATION
 
    The Fund normally makes payment for all shares redeemed within one business
day of receipt of the request, and in no event more than seven days after
receipt of a redemption request in good order. However, payments to investors
redeeming shares which were purchased by check will not be made until payment
for the purchase has been collected, which may take up to eight days after the
date of purchase. The Fund may suspend the right of redemption or postpone the
date upon which redemptions are effected at times when the NYSE is closed, or
under any emergency conditions as determined by the Commission.
 
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of a Portfolio to make payment in
cash, the Fund may pay redemption proceeds in whole or in part by a
distribution-in-kind of readily marketable portfolio securities in accordance
with applicable rules of the Commission. Shareholders may incur brokerage
charges on the sale of portfolio securities received in payment of redemptions.
 
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required to verify the identity of the person who has authorized
certain redemptions. Please contact the Fund for further information. See
"Redemption of Shares" in the Statement of Additional Information.
 
                         ACCOUNT POLICIES AND SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares of each Portfolio that you own for shares of any
other available portfolio(s) of the Fund, subject to certain limitations. You
cannot exchange for shares of the International Equity, Emerging Markets, Small
Cap Value Equity, Balanced and Gold Portfolios because they are currently closed
to new investors. In addition, certain portfolios may be unavailable to
shareholders who purchased portfolio shares through a Financial Intermediary.
Contact your Financial Intermediary to determine which portfolios are available
for exchange.
 
                                       32
<PAGE>
    Before you make an exchange, you should read the prospectus of the
portfolio(s) in which you seek to invest. The class of shares you receive in the
exchange will be determined in the same manner as any other purchases of shares,
including minimum initial investment and account size requirements, and will not
be based on the class of shares you surrender for the exchange. Exchange
transactions are treated as a redemption followed by a purchase. Therefore, an
exchange will be considered a taxable event for shareholders subject to tax.
Exchange transactions will be processed at the net asset value per share next
determined after receipt of the request. Shares of the portfolios may be
exchanged by mail or telephone. The telephone exchange privilege is automatic
and made available without shareholder election. The exchange privilege may be
modified or terminated by the Fund at any time upon 60-days notice to
shareholders.
 
    BY MAIL.  To exchange shares by mail, send a written exchange request to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798. Your written exchange request should include (i) the name, class of
shares and account number of your current Portfolio; (ii) the name(s) and
class(es) of shares of the portfolio(s) into which you intend to exchange
shares; and (iii) the signatures of all registered account holders.
 
    BY TELEPHONE.  To exchange shares by telephone, call the Fund at the phone
number provided on the cover of this Prospectus. A Fund representative will
request (i) the name, class of shares and account number of your current
Portfolio, and (ii) the name(s) and class(es) of shares of the portfolio(s) into
which you intend to exchange shares. For additional information regarding
responsibility for the authenticity of telephoned instructions, see "Redemption
of Shares" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by sending a written request to Morgan Stanley Institutional Fund, Inc.,
P.O. Box 2798, Boston, Massachusetts 02208-2798. It may not be possible to
transfer the registration of certain shares purchased through a Financial
Intermediary. As with redemptions, the written request must be received in "good
order" before any transfer can be made. Transferring the registration of shares
may affect the eligibility of your account for a given class of shares and may
result in involuntary conversion or redemption of your shares.
 
OTHER ACCOUNT INFORMATION
 
    The Fund does not issue share certificates for the Portfolios. All shares
purchased are confirmed to you and credited to your account on the Fund's books
maintained by the Adviser or its agents. You will have the same rights and
ownership with respect to such shares as if certificates had been issued.
 
EXCESSIVE TRADING
 
    Frequent trades in your account(s) can disrupt management of a Portfolio and
raise its expenses. Consequently, the Fund may, in its discretion and in the
interest of each Portfolio's shareholders and performance, bar a shareholder who
trades excessively from making further share purchases for an indefinite period.
The Fund considers excessive trading to be more than one purchase and sale
involving shares of the same class of a portfolio of the Fund within any 120-day
period. For example, the following series of transactions would amount to
excessive trading: exchanging shares of Portfolio A for shares of Portfolio B,
then exchanging shares of Portfolio B for shares of Portfolio C and then
exchanging shares of Portfolio C for shares of Portfolio A within a 120-day
 
                                       33
<PAGE>
period. Two types of transactions are exempt from these excessive trading
restrictions: (i) trades exclusively between money market portfolios, and (ii)
trades made in connection with an asset allocation service managed or advised by
the Adviser and/or any of its affiliates.
 
INVESTMENT IN PORTFOLIOS BY OTHER INVESTMENT ACCOUNTS
 
    Morgan Stanley or its affiliates, including Morgan Stanley Asset Management
Inc., manage investment accounts for other clients, including other investment
companies, that invest in Class A or Class B shares of the portfolios. From time
to time, one or more of the portfolios used for investment by these accounts may
experience relatively large investments or redemptions due to investment
decisions made on behalf of these accounts. These transactions will affect the
portfolios, since portfolios that experience significant redemptions may have to
sell portfolio securities and portfolios that receive additional cash will have
to invest it in additional portfolio securities. It is impossible to predict the
overall impact of these transactions over time, however, there could be adverse
effects on portfolio management. These transactions also could have tax
consequences if sales of portfolio securities result in gains or could increase
transaction costs. The Adviser, representing the interests of the portfolios, is
committed to minimizing the impact of these transactions to the portfolios. The
Adviser, however, will have a conflict in fulfilling this responsibility in that
it also advises these investment accounts. The Adviser will monitor the impact
of these transactions on the portfolio.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of each Non-Money
Portfolio is determined by dividing the total market value of the Non-Money
Portfolio's investments and other assets attributable to such class, less all
liabilities attributable to such class, by the number of total outstanding
shares of such a class of the Non-Money Portfolio. Net asset value is calculated
separately for each class of the Portfolio. Net asset value per share of the
Non-Money Portfolios is determined as of the close of the NYSE (normally 4:00
p.m. Eastern Time) on each day that the NYSE is open for business. Price
information on listed securities is taken from the exchange where the security
is primarily traded. Securities listed on a U.S. securities exchange for which
market quotations are available are valued at the last quoted sale price on the
day the valuation is made. Securities listed on a foreign exchange are valued at
their closing price. Unlisted securities and listed securities not traded on the
valuation date and for which market quotations are not readily available are
valued at a price within a range not exceeding the current asked price nor less
than the current bid price. The current bid and asked prices are determined
based on the average of the bid and asked prices quoted on such valuation date
by two reputable brokers.
 
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily unless collection is in doubt. In addition, bonds and other fixed
income securities may be valued on the basis of prices provided by a pricing
service when such prices are believed to reflect the fair market value of such
securities. The prices provided by a pricing service are determined without
regard to bid or last sale prices, but take into account institutional size
trading in similar groups of securities and any developments related to the
specific securities. Securities not priced in this manner are valued at the most
recently quoted bid price or, when securities exchange valuations are used, at
the latest quoted sale price on the day of valuation. If there is no such
reported sale, the latest quoted bid price will be used. Securities purchased
with remaining maturities of 60 days or less are valued at amortized cost, if it
approximates market value. In the event that amortized cost does not approximate
market value, market prices as determined above will be used.
 
                                       34
<PAGE>
    The value of other assets and securities for which quotations are not
readily available (including restricted and unlisted foreign securities) and
those securities for which it is inappropriate to determine prices in accordance
with the above-stated procedures are determined in good faith at fair value
using methods determined by the Board of Directors. For purposes of calculating
net asset value per share, all assets and liabilities initially expressed in
foreign currencies will be converted into U.S. dollars at the mean of the bid
and asked price for such currencies against the U.S. dollar last quoted by any
major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distribution expense accrual differential among the classes. The
net asset value of Class B shares will generally be lower than the net asset
value of Class A shares as a result of the distribution expenses charged to
Class B shares.
 
    The net asset value per share of each of the Money Market and Municipal
Money Market Portfolios is determined by subtracting the Portfolio's liabilities
(including accrued expenses and dividends payable) from the total value of the
Portfolio's investments and other assets and dividing the result by the total
number of outstanding shares of the Portfolio. The net asset values per share of
the Municipal Money Market Portfolio and the Money Market Portfolio are
determined as of 11:00 a.m. and 12:00 noon (Eastern Time), respectively, on the
days on which the NYSE is open. For the purpose of calculating each Money
Portfolio's net asset value per share, securities are valued by the "amortized
cost" method of valuation, which does not take into account unrealized gains or
losses. This involves valuing an instrument at its cost and thereafter assuming
a constant amortization to maturity of any discount or premium, regardless of
the impact of fluctuating interest rates on the market value of the instrument.
While this method provides certainty in valuation, it may result in periods
during which the value, as determined by amortized cost, is higher or lower than
the price the Portfolio would receive if it sold the instrument.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise total return for each class of the
Fixed Income, Municipal Bond and Mortgage-Backed Securities Portfolios. In
addition, from time to time the Fund may advertise "yield" for the Municipal
Bond, Money Market and Municipal Money Market Portfolios and "effective yield"
for the Money Market and Municipal Money Market Portfolios. In addition to these
yield figures, the Municipal Bond and Municipal Money Market Portfolio may
advertise a tax equivalent yield. THESE FIGURES ARE BASED ON HISTORICAL
PERFORMANCE AND ARE NOT INTENDED TO INDICATE FUTURE PERFORMANCE.
 
    Each of the Non-Money Portfolios may advertise "total return" which shows
what an investment in a class of the Portfolio would have earned over a
specified period of time (such as one, five or ten years) assuming that all
distributions and dividends by the Portfolio were reinvested in the same class
on the reinvestment dates during the period. Total return does not take into
account any federal or state income taxes that may be payable on dividends and
distributions or upon redemption. The "yield" of the Municipal Bond Portfolio
refers to the income generated by an investment in the Portfolio over a
one-month or 30-day period, while the "yield" of the Money Market and Municipal
Money Market Portfolios refers to the income generated by an investment in the
Portfolio over a seven-day period (which period will be stated in the
advertisement). This income is then "annualized." That is, the amount of income
generated by the investment during that 30- or seven-day period is assumed to be
generated each 30-day period for twelve periods or each week over a 52-week
period, and is
 
                                       35
<PAGE>
shown as a percentage of the investment. The "effective yield" is calculated
similarly but, when annualized, the income earned on an investment in the
Portfolio is assumed to be reinvested. The "effective yield" will be slightly
higher than the "yield" because of the compounding effect of this assumed
reinvestment. A "tax equivalent yield" is the "yield" of the Portfolio increased
by an amount based on an assumed rate of tax for a shareholder. For further
information concerning these figures, see "Calculation of Yield and Total
Return" in the Statement of Additional Information. The Fund may also use
comparative performance information in marketing the Portfolios' shares,
including data from Lipper Analytical Services, Inc., Donoghue's Money Fund
Report, other industry publications, business periodicals, rating services and
market indices.
 
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
FIXED INCOME, MUNICIPAL BOND AND MORTGAGE-BACKED SECURITIES PORTFOLIOS
 
    All income dividends and capital gains distributions for a class of shares
of each Non-Money Portfolio will be automatically reinvested in additional
shares of such class at net asset value, except that, upon written notice to the
Fund or by checking off the appropriate box in the Distribution Option Section
on the Account Registration Form, a shareholder may elect to receive income
dividends and capital gains distributions in cash.
 
    Each Non-Money Portfolio expects to distribute substantially all of its
taxable net investment income in the form of monthly dividends. Net realized
capital gains of each Non-Money Portfolio, if any, after reduction for any tax
loss carryforwards will also be distributed annually.
 
    Undistributed net investment income is included in each Non-Money
Portfolio's net assets for the purpose of calculating net asset value per share.
Therefore, on the "ex-dividend" date, the net asset value per share excludes the
dividend (I.E., is reduced by the per share amount of the dividend). Dividends
paid shortly after the purchase of shares by an investor, although in effect a
return of capital, are taxable to shareholders subject to income tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of each Non-Money Portfolio will differ
at times. Expenses of each Non-Money Portfolio allocated to a particular class
of shares will be borne on a pro rata basis by each outstanding share of that
class.
 
MONEY MARKET AND MUNICIPAL MONEY MARKET PORTFOLIOS
 
    Net investment income is computed and dividends declared as of 1:00 p.m.
(Eastern time), on each day. Such dividends are payable to Municipal Money
Market Portfolio shareholders of record as of 11:00 a.m. (Eastern time) on that
day and to Money Market Portfolio shareholders of record as of 12:00 noon
(Eastern time) on that day, if the Fund and Custodian Bank are open for
business. This means that shareholders whose purchase orders become effective as
of 12:00 noon (for the Money Market Portfolio) or 11:00 a.m. (for the Municipal
Money Market Portfolio) receive the dividend for that day. Dividends declared
for Saturdays, Sundays and holidays are payable to shareholders of record as of
4:00 p.m. on the last preceding day the Fund and its Custodian Bank were open
for business.
 
                                       36
<PAGE>
    For the purpose of calculating dividends, net income of each Money Portfolio
shall consist of interest earned, including any discount or premium ratably
amortized to the date of maturity, minus estimated expenses of the Money
Portfolio. Each Money Portfolio's daily dividends are accrued throughout the
month and are distributed on the fifteenth calendar day of each month (or next
business day if the fifteenth calendar day falls on a holiday or weekend).
Because of the distribution fee and other expenses that may be attributable to
Class B shares of the Money Market Portfolio, the net income attributable to and
the dividends payable on Class B shares will be lower than for Class A shares.
Dividends of each Money Portfolio are payable in additional shares, except that,
upon written notice to the Fund or by checking off the appropriate box in the
Distribution Option Section on the Account Registration Form, a shareholder may
elect to receive income dividends and any capital gains distributions in cash.
 
    Each shareholder receives a monthly statement summarizing activity in the
account. If at any time a shareholder wishes to withdraw all of the funds in an
account, the proceeds will be sent to the shareholder by wire or check,
according to the shareholder's instructions. If the withdrawal is by wire, a
check in the amount of the income to the shareholder's account through the day
of withdrawal will be mailed to the shareholder on the next business day.
Withdrawals by check will include accrued income through the date of withdrawal.
 
    Net realized short-term capital gains, if any, of each Money Portfolio are
to be distributed whenever the Board of Directors determine that such
distributions would be in the best interest of shareholders, but in any event,
at least once a year. The Money Portfolios do not expect to realize any
long-term capital gains. Should any such gains be realized, they will be
distributed annually.
 
    It is an objective of management to maintain the price per share of each
Money Portfolio as computed for the purpose of sales and redemptions at exactly
$1.00. In the event the Board of Directors determines that a deviation from the
$1.00 per share price may exist which may result in a material dilution or other
unfair results to investors or existing shareholders, they will take corrective
action they regard as necessary and appropriate, including the sale of
instruments from a Money Portfolio prior to maturity to realize capital gains or
losses; shortening average portfolio maturity; withholding dividends; making a
special capital distribution; or redemptions of shares in kind.
 
                                     TAXES
 
GENERAL
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of a Portfolio or its shareholders.
Accordingly, shareholders are urged to consult their tax advisors regarding
specific questions as to federal, state and local income taxes.
 
    Each Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other Portfolios. Each Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Internal Revenue Code of 1986, as amended
(the "Code"), so that the Portfolio will be relieved of federal income tax on
that part of its net investment income and net capital gain that is distributed
to shareholders.
 
                                       37
<PAGE>
    Each Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, net short-term capital gain) to
shareholders. Dividends from a Portfolio's net investment income (other than
"exempt-interest dividends," described below) are taxable to shareholders as
ordinary income, whether received in cash or in additional shares. Distributions
of net capital gain are taxable to shareholders as a 20% rate gain distribution
(taxed at a rate of 20%) or a 28% rate gain distribution (taxed at a rate of
28%), depending upon the designation by the Portfolio (such designation being
dependent upon the holding period of the Portfolio in the underlying asset
generating the net capital gain), regardless of how long shareholders have held
their shares. Distributions of net investment income and net capital gain are
not eligible for the corporate dividends-received deduction. Each Portfolio will
send reports annually to its shareholders of the federal income tax status of
all distributions made during the preceding year.
 
    Each Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gain over short-term and long-term capital
loss, including any available capital loss carryforwards) prior to the end of
each calendar year to avoid liability for federal excise tax.
 
    Dividends and other distributions declared by a Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders on December 31 of that year if the distributions are paid by
the Portfolio at any time during the following January.
 
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any dividends, capital gains distributions and redemption proceeds paid to any
individual or certain other non-corporate shareholder (i) who has failed to
provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Account Registration Form; (ii) who is subject to backup withholding by the
Internal Revenue Service; or (iii) who has not certified to the Fund that such
shareholder is not subject to backup withholding. This backup withholding is not
an additional tax, and any amounts withheld may be credited against the
shareholder's ultimate U.S. tax liability.
 
    The sale, exchange or redemption of shares will result in taxable gain or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the redemption proceeds exceed or are less than the
shareholder's adjusted basis in the sold, exchanged or redeemed shares. If
capital gains distributions have been made with respect to shares that are sold
at a loss after being held for six months or less, then the loss is treated as a
long-term capital loss to the extent of the capital gains distributions.
 
    Conversions of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisors concerning the
application of state and local income taxes to investments in a Portfolio, which
may differ from the federal income tax consequences described above.
 
THE MUNICIPAL BOND AND MUNICIPAL MONEY MARKET PORTFOLIOS
 
    The dividends payable by the Municipal Bond and the Municipal Money Market
Portfolios from net tax-exempt interest from municipal bonds and notes will
qualify as "exempt-interest dividends" if, at the close of each quarter of its
taxable year, at least 50% of the value of its total assets consists of
securities the interest on
 
                                       38
<PAGE>
which is excludable from gross income. Each of the Municipal Bond and Municipal
Money Market Portfolios intends to invest a sufficient portion of its assets in
municipal bonds and notes to qualify to pay "exempt-interest dividends."
 
    Exempt-interest dividends are excludable from a shareholder's gross income
for regular income tax purposes. However, the receipt of such dividends may have
collateral federal income tax consequences, including alternative minimum tax
consequences. In addition, the receipt of exempt-interest dividends may cause
persons receiving Social Security or Railroad Retirement benefits to be taxable
on a portion of such benefits. See the Statement of Additional Information.
Current federal tax law limits the types of volume of bonds qualifying for the
federal income tax exemption of interest, which may have an effect on the
ability of the Portfolios to purchase sufficient amounts of tax-exempt
securities to satisfy the Code's requirement for the payment of exempt-interest
dividends.
 
    All or a portion of the interest on indebtedness incurred or continued by an
investor to purchase or carry shares is not deductible for federal income tax
purposes. Furthermore, entities or persons who are "substantial users" (or
persons related to "substantial users") of facilities financed by "private
activity bonds" or "industrial development bonds" should consult their tax
advisors before purchasing shares of the Portfolios. See the Statement of
Additional Information.
 
    The Portfolios will report annually to their shareholders the portion of
dividends that is taxable and the portion that is tax-exempt based on income
received by the Portfolios during the year to which the dividends relate.
 
    The exemption of dividends paid by the Municipal Bond and Municipal Money
Market Portfolio for Federal income tax purposes may not result in similar
exemptions under the laws of a particular state or local taxing authority. Each
of the Municipal Bond and Municipal Money Market Portfolio will report annually
to its shareholders the percentage and source, on a state-by-state basis, of
interest income earned on municipal bonds and municipal notes held by the
Portfolio during the preceding year.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN A PORTFOLIO.
 
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolio
for their clients.
 
                                       39
<PAGE>
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other remuneration paid to Morgan Stanley or other affiliates must be
fair and reasonable in comparison to those of other broker-dealers for
comparable transactions involving similar securities being purchased or sold
during a comparable time period.
 
PORTFOLIO TURNOVER
 
    The Portfolios generally do not invest for short-term trading purposes,
however, when circumstances warrant, each Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolios will not consider portfolio turnover rate
a limiting factor in making investment decisions consistent with their
respective objectives and policies. For the fiscal year ended December 31, 1997,
the Fixed Income Portfolio had a portfolio turnover rate of 163%. Higher
portfolio turnover (e.g., over 100%) necessarily will cause the Portfolios to
pay correspondingly increased brokerage and trading costs. In addition to
transaction costs, higher portfolio turnover may result in the realization of
capital gains. As discussed under "Taxes," to the extent net short-term capital
gains are realized, any distributions resulting from such gains are considered
ordinary income for federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 40 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of each
portfolio are currently classified into two classes, the Class A shares and
Class B shares, except for the International Small Cap and Municipal Money
Market Portfolios, which offer only Class A shares.
 
    The shares of each Portfolio, when issued, will be fully paid,
nonassessable, fully transferable and redeemable at the option of the holder.
The shares have no preference as to conversion, exchange, dividends, retirement
or other features and have no pre-emptive rights. The shares of each Portfolio
have non-cumulative voting rights, which means that the holders of more than 50%
of the shares voting for the election of Directors can elect 100% of the
Directors if they choose to do so. Persons or organizations owning 25% or more
of the outstanding shares of a Portfolio may be presumed to "control" (as that
term is defined in the 1940 Act) that Portfolio. Under Maryland law, the Fund is
not required to hold an annual meeting of its shareholders unless required to do
so under the 1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual and semi-annual reports.
Financial statements appearing in annual reports are audited by independent
accountants. Monthly unaudited portfolio data is also available from the Fund
upon request.
 
                                       40
<PAGE>
    In addition, the Adviser, or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
CUSTODIAN
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs subcustodians approved by the Board of Directors of the Fund
in accordance with regulations of the Commission for the purpose of providing
custodial services for such assets. MSTC may also hold certain domestic assets
for the Fund. For more information on the custodians, see "General Information
- -- Custody Arrangements" in the Statement of Additional Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits its annual financial statements.
 
FUND COUNSEL
 
    Morgan, Lewis & Bockius LLP acts as the Fund's legal counsel.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       41
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
  FIXED INCOME, MUNICIPAL BOND, MORTGAGE-BACKED SECURITIES,
   MONEY MARKET AND MUNICIPAL MONEY MARKET PORTFOLIOS
   P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                            <C>
      ACCOUNT INFORMATION                            If you need assistance in filling out this form for the Morgan Stanley
      Fill in where applicable                       Institutional Fund, Inc., please contact your Morgan Stanley
                                                     representative or call us toll free 1-800-548-7786. Please print all
                                                     items except signature, and mail to the Fund at the address above.
 
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
         TENANCY IN COMMON
         IS INDICATED)
</TABLE>
 
1.
         First Name    Initial         Last Name
 
2.
         First Name    Initial         Last Name
 
         First Name    Initial         Last Name
 
<TABLE>
<C>   <S>                                            <C>
      3. CORPORATIONS,
         TRUSTS AND OTHERS
         Please call the Fund for additional
      documents that may be required to set up
      account and to authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                     <C>                 <C>                   <C>               <C>
Type of Registration:   / / INCORPORATED    / / UNINCORPORATED    / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                            ASSOCIATION                               (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
<TABLE>
<C>        <S>                             <C>
       B)  MAILING ADDRESS
           Please fill in completely,
           including telephone number(s).
 
<CAPTION>
       B)
 
<CAPTION>
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
 
/ / Non-Resident Alien
 
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
 
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
 
<TABLE>
<S>   <S>                                            <C>                                  <C>
  C)  TAXPAYER                                       Enter your Taxpayer Identification Number. For most individual
      IDENTIFICATION                                 taxpayers, this is your Social Security Number.
      NUMBER
      1. INDIVIDUAL
      2.   JOINT TENANTS
           (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
           TENANCY IN COMMON
           IS INDICATED)
</TABLE>
<PAGE>
<TABLE>
<S>   <S>                                            <C>                                  <C>
      For Custodian account
      of a minor (Uniform
      Gifts/Transfers to Minor
      Acts), give the Social
      Security Number of
      the minor.
                                                                                          OR
                                                     1.         TAXPAYER IDENTIFICATION                      SOCIAL SECURITY
                                                     NUMBER ("TIN")                                NUMBER ("SSN")
                                                                                              OR
                                                     2.                             TIN
                                                                                                                             SSN
                                                                                              OR
                                                     TIN
                                                                                                                             SSN
 
                                                     IMPORTANT TAX INFORMATION
                                                     You (as a payee) are required by law to provide us (as payer) with your
                                                     correct TIN(s) or SSN(s). Accounts that have a missing or incorrect
                                                     TIN(s) or SSN(s) will be subject to backup withholding at a 31% rate on
                                                     dividends, distributions and other payments. If you have not provided us
                                                     with your correct TIN(s) or SSN(s), you may be subject to a $50 penalty
                                                     imposed by the Internal Revenue Service.
                                                     Backup withholding is not an additional tax; the tax liability of
                                                     persons subject to backup withholding will be reduced by the amount of
                                                     tax withheld. If withholding results in an overpayment of taxes, a
                                                     refund may be obtained.
                                                     You may be notified that you are subject to backup withholding under
                                                     Section 3406(a)(1)(C) of the Internal Revenue Code because you have
                                                     underreported interest or dividends or you were required to, but failed
                                                     to, file a return which would have included a reportable interest or
                                                     dividend payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>                             <C>                   <C>
  D)  PORTFOLIO AND                        For Purchase of the following   / / Class A Shares $  / / Class B Shares $
      CLASS SELECTION                      Portfolio(s):                   / / Class A Shares $  / / Class B Shares $
      (Class A shares minimum $500,000     Fixed Income Portfolio          / / Class A Shares $  / / Class B Shares $
      and Class B shares minimum $100,000  Municipal Bond Portfolio        / / Class A Shares $
      for each of the Fixed Income,        Mortgage-Backed Securities      / / Class A Shares $
      Municipal Bond and Mortgage-Backed   Portfolio
      Securities Portfolios. Minimum       Money Market Portfolio
      $50,000 for Class A shares of each   Municipal Money Market
      of the Money Market and Municipal    Portfolio
      Money Market Portfolios). Please
      indicate Portfolio, class and
      amount.
                                                                           Total Initial Investment $
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate portfolio
      and manner of payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                          <C>
/ / Exchange $ From                                                                     -- - - - - - - - - - -- - -
                            Name of Portfolio                                                   Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on                 -- - - - - - - - - - -- - -
                                                                                      Account No.               (Check
                                                                                (Previously assigned by the Fund)     Digit)
                                                                                                                          Date
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  F)  DISTRIBUTION               Income dividends and capital gains distributions (if any) to
      OPTION                     be reinvested in additional shares unless either box below
                                 is checked.
                                 / / Income dividends to be paid in cash, capital gains
                                 distributions (if any) in shares.
                                 / / Income dividends and capital gains distributions (if
                                 any) to be paid in cash.
</TABLE>
 
<TABLE>
<C>   <S>                             <C>                                       <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone         Name of COMMERCIAL Bank (Not Savings
      AND EXCHANGE                    requests to wire redemption proceeds to   Bank)
      OPTION                          the commercial bank indicated at right    Bank Account No.
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund
      wish to redeem or exchange      account is registered if such requests                                        Bank
      shares by telephone. A          are believed to be authentic.                                                  ABA
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent                                         No.
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated    Name(s) in which your Bank Account is
      YOUR FUND ACCOUNT.              by telephone are genuine. These           Established
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal      Bank's Street
      NOT BE HONORED UNLESS THE BOX   identification information at the time    Address
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by   City  State  Zip
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  H)  INTERESTED PARTY
      OPTION                                                                                                Name
      In addition to the account
      statement sent to my/our registered
      address, I/we hereby authorize the                                                                   Address
      Fund to mail duplicate statements
      to the name and address provided at  City         State         Zip Code
      right.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  I)  DEALER
      INFORMATION
                                           Representative Name              Representative No.             Branch
                                           No.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here ,
</TABLE>
 
<TABLE>
<S>                                  <C>
The undersigned certify that I/we have full authority and legal capacity
to purchase and redeem shares of the Fund and affirm that I/we have
received a current Prospectus of the Morgan Stanley Institutional Fund,
Inc. and agree to be bound by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF
PERJURY THAT THE INFORMATION ON THIS APPLICATION IS COMPLETE AND CORRECT
AND THAT AS REQUIRED BY FEDERAL LAW (PLEASE CHECK APPLICABLE BOXES
BELOW):
 
/ / U.S. CITIZEN(S)/TAXPAYER(S):
 
      / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM
          IS/ARE THE CORRECT SSN(S) OR TIN(S) AND (2) I/WE ARE NOT
          SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE ARE
          EXEMPT FROM BACKUP WITHHOLDING; (B) I/WE HAVE NOT BEEN
          NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT I/WE ARE
          SUBJECT TO BACKUP WITHHOLDING AS A RESULT OF A FAILURE TO
          REPORT ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED
          ME/US THAT I AM/WE ARE NO LONGER SUBJECT TO BACKUP
          WITHHOLDING.
 
      / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE HAVE
          APPLIED, OR INTEND TO APPLY, TO THE IRS OR THE SOCIAL SECURITY
          ADMINISTRATION FOR A TIN OR A SSN AND I/WE UNDERSTAND THAT IF
          I/ WE DO NOT PROVIDE EITHER NUMBER TO CHASE GLOBAL FUNDS
          SERVICES COMPANY ("CGFSC") WITHIN 60 DAYS OF THE DATE OF THIS
          APPLICATION OR IF I/WE FAIL TO FURNISH MY/OUR CORRECT SSN(S)
          OR TIN(S), I/WE MAY BE SUBJECT TO A PENALTY AND A 31% BACKUP
          WITHHOLDING ON DISTRIBUTIONS AND REDEMPTION PROCEEDS. (PLEASE
          PROVIDE EITHER NUMBER ON IRS FORM W-9). YOU MAY REQUEST SUCH
          FORM BY CALLING CGFSC AT 800-282-4404.
 
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
  UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S.
CITIZENS OR RESIDENTS AND I/WE ARE EXEMPT FOREIGN PERSONS AS DEFINED BY
THE INTERNAL REVENUE SERVICE.
 
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY
PROVISION OF THIS DOCUMENT OTHER THAN THE CERTIFICATIONS REQUIRED TO
AVOID BACKUP WITHHOLDING.
 
                                     (X)
(X)                                  Signature (if joint account, both
Signature            Date            must sign)      Date
</TABLE>
<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<S>                                                 <C>
                                                    PAGE
                                                    ----
Fund Expenses.....................................    2
Financial Highlights..............................    4
Prospectus Summary................................    9
Investment Objectives and Policies................   13
Additional Investment Information.................   17
Investment Limitations............................   25
Management of the Fund............................   25
Purchase of Shares................................   28
Redemption of Shares..............................   31
Account Policies and Services.....................   32
Valuation of Shares...............................   34
Performance Information...........................   35
Dividends and Capital Gains Distributions.........   36
Taxes.............................................   37
Portfolio Transactions............................   39
General Information...............................   40
Account Registration Form
</TABLE>
 
                             FIXED INCOME PORTFOLIO
                            MUNICIPAL BOND PORTFOLIO
                      MORTGAGE-BACKED SECURITIES PORTFOLIO
                             MONEY MARKET PORTFOLIO
                        MUNICIPAL MONEY MARKET PORTFOLIO
 
                               PORTFOLIOS OF THE
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
 
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  Incorporated
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
                      P.O. Box 2798, Boston, MA 02208-2798
 
- ---------------------------------
- ---------------------------------
- ---------------------------------
- ---------------------------------
<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
     ----------------------------------------------------------------------
                        SMALL CAP VALUE EQUITY PORTFOLIO
                             VALUE EQUITY PORTFOLIO
                               BALANCED PORTFOLIO
                         GLOBAL FIXED INCOME PORTFOLIO
                              HIGH YIELD PORTFOLIO
                               PORTFOLIOS OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
                                ----------------
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a series of diversified and non-diversified investment portfolios
("portfolios"). The Fund is designed to provide clients with attractive
alternatives for meeting their investment needs. The Fund currently consists of
thirty-two portfolios representing a broad range of investment choices. This
prospectus (the "Prospectus") pertains to the Class A and the Class B shares of
the Small Cap Value Equity, Value Equity, Balanced, Global Fixed Income and High
Yield Portfolios (each, a "Portfolio," and collectively, the "Portfolios"). The
Class A and Class B shares currently offered by the Portfolios have different
minimum investment requirements and fund expenses. Shares of the Portfolios are
offered with no sales charge, exchange fee or redemption fee. The Small Cap
Value Equity and Balanced Portfolios are currently closed to new investors with
the exception of certain tax-qualified retirement plans, other investment
companies advised by Morgan Stanley Asset Management Inc. and its affiliates and
certain employees of the Adviser and its affiliates.
    THE HIGH YIELD PORTFOLIO INVESTS PREDOMINANTLY IN LOWER RATED BONDS,
COMMONLY REFERRED TO AS "JUNK BONDS." BONDS OF THIS TYPE ARE CONSIDERED TO BE
SPECULATIVE WITH REGARD TO THE PAYMENT OF INTEREST AND RETURN OF PRINCIPAL.
INVESTORS SHOULD CAREFULLY ASSESS THE RISKS ASSOCIATED WITH AN INVESTMENT IN
THIS PORTFOLIO. SEE "RISK FACTORS RELATING TO INVESTING IN HIGH YIELD
SECURITIES."
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator"), and with Morgan Stanley & Co. Incorporated ("Morgan Stanley")
as Distributor, the Fund makes available to institutional and high net worth
individual investors a series of portfolios which benefit from the investment
expertise and commitment to excellence associated with Morgan Stanley and its
affiliates.
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under "Prospectus Summary" below. The Fund
currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging Markets,
European Equity, European Real Estate, Global Equity, International Equity,
International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) EQUITY AND FIXED INCOME -- Balanced
Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global
Fixed Income, High Yield and Municipal Bond Portfolios; and (v) MONEY MARKET --
Money Market and Municipal Money Market Portfolios. Additional information about
the Fund is contained in a "Statement of Additional Information", dated May 1,
1998, which is incorporated herein by reference. The Statement of Additional
Information and the prospectuses pertaining to the other portfolios of the Fund
are available upon request and without charge by writing or calling the Fund at
the address and telephone number set forth above.
  THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
EXCHANGE COMMISSION, NOR HAS THE SECURITIES AND EXCHANGE COMMISSION PASSED UPON
        THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION
                     TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
                  THE DATE OF THIS PROSPECTUS IS MAY 1, 1998.
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates the expenses and fees that a shareholder of
each Portfolio will incur:
 
<TABLE>
<CAPTION>
                                                                                  GLOBAL
                                     SMALL CAP VALUE                               FIXED      HIGH
                                         EQUITY        VALUE EQUITY   BALANCED    INCOME      YIELD
SHAREHOLDER TRANSACTION EXPENSES        PORTFOLIO       PORTFOLIO     PORTFOLIO  PORTFOLIO  PORTFOLIO
- -----------------------------------  ---------------   ------------   --------   ---------  ---------
<S>                                  <C>               <C>            <C>        <C>        <C>
Maximum Sales Load Imposed on
 Purchases
  Class A..........................        None            None         None       None       None
  Class B..........................        None            None         None       None       None
Maximum Sales Load Imposed on
 Reinvested Dividends
  Class A..........................        None            None         None       None       None
  Class B..........................        None            None         None       None       None
Deferred Sales Load
  Class A..........................        None            None         None       None       None
  Class B..........................        None            None         None       None       None
Redemption Fees
  Class A..........................        None            None         None       None       None
  Class B..........................        None            None         None       None       None
Exchange Fees
  Class A..........................        None            None         None       None       None
  Class B..........................        None            None         None       None       None
</TABLE>
 
<TABLE>
<CAPTION>
                                                                                  GLOBAL
ANNUAL FUND OPERATING EXPENSES       SMALL CAP VALUE                               FIXED       HIGH
 (AS A PERCENTAGE OF AVERAGE NET         EQUITY        VALUE EQUITY   BALANCED    INCOME       YIELD
 ASSETS)                                PORTFOLIO       PORTFOLIO     PORTFOLIO  PORTFOLIO   PORTFOLIO
- -----------------------------------  ---------------   ------------   --------   ---------   ---------
<S>                                  <C>               <C>            <C>        <C>         <C>
Management Fee (Net of Fee
 Waivers)*
  Class A..........................       0.53%           0.40%        0.00%       0.19%           0.375%
  Class B..........................       0.53%           0.40%        0.00%       0.19%           0.375%
12b-1 Fees
  Class A..........................        None            None         None        None     None
  Class B..........................       0.25%           0.25%        0.25%       0.15%**         0.25%
Other Expenses
  Class A..........................       0.47%           0.30%        0.70%       0.31%           0.32%
  Class B..........................       0.47%           0.30%        0.70%       0.31%           0.30%
                                        -------          ------       --------   ---------   ---------
Total Operating Expenses (Net of
 Fee Waivers)*
  Class A..........................       1.00%           0.70%        0.70%       0.50%           0.695%
  Class B..........................       1.25%           0.95%        0.95%       0.65%           0.925%
                                        -------          ------       --------   ---------   ---------
                                        -------          ------       --------   ---------   ---------
</TABLE>
 
- --------------------------
 *The Adviser has agreed to waive its management fee and/or reimburse the
  Portfolios, if necessary, if such fees would cause the total annual operating
  expenses of each of the Portfolios to exceed a specified percentage of its
  respective average daily net assets. As a result of these reductions, the
  Management Fees stated above are lower than the contractual fees stated under
  "Management of the Fund." The Adviser reserves the right to terminate any of
  its fee waivers and/or expense reimbursements at any time in its sole
  discretion. For further information on Fund expenses, see "Management of the
  Fund." Set forth below, for each Portfolio, are the management fees and total
  operating expenses absent such fee waivers and/or expense reimbursements as a
  percentage of the average daily net assets of the Class A shares and Class B
  shares, respectively.
 
                                       2
<PAGE>
 
<TABLE>
<CAPTION>
                                                                                      TOTAL OPERATING EXPENSES
                                                                                         ABSENT FEE WAIVERS
                                                                   MANAGEMENT FEE     -------------------------
PORTFOLIO                                                        ABSENT FEE WAIVERS     CLASS A      CLASS B
- ---------------------------------------------------------------  -------------------  -----------  ------------
<S>                                                              <C>                  <C>          <C>
Small Cap Value Equity.........................................          0.85%             1.32%        1.56%
Value Equity...................................................          0.50%             0.80%        1.04%
Balanced.......................................................          0.50%             1.83%        2.05%
Global Fixed Income............................................          0.40%             0.71%        0.86%
High Yield.....................................................          0.375%            0.69%        0.93%
</TABLE>
 
**The Distributor has agreed to waive 0.10% of the 0.25% distribution fee it is
  entitled to receive from this Portfolio.
 
    The purpose of the table above is to assist the investor in understanding
the various expenses that an investor in the Portfolios will bear directly or
indirectly. Expenses and fees for each Portfolio are based on actual figures for
the fiscal year ended December 31, 1997. Due to the continuous nature of Rule
12b-1 fees, long-term Class B shareholders may pay more than the equivalent of
the maximum front-end sales charges otherwise permitted by the National
Association of Securities Dealers, Inc. ("NASD") Conduct Rules.
 
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (i) a 5% annual rate of return, and (ii) redemption
at the end of each time period. As noted in the table above, the Portfolios
charge no redemption fees of any kind. The following example is based on total
operating expenses of the Portfolios after fee waivers.
 
<TABLE>
<CAPTION>
                                                                       1 YEAR       3 YEARS      5 YEARS     10 YEARS
                                                                     -----------  -----------  -----------  -----------
<S>                                                                  <C>          <C>          <C>          <C>
Small Cap Value Equity Portfolio
  Class A..........................................................   $      10    $      32    $      55    $     122
  Class B..........................................................          13           40           69          151
Value Equity Portfolio
  Class A..........................................................           7           22           39           87
  Class B..........................................................          10           30           53          117
Balanced Portfolio
  Class A..........................................................           7           22           39           87
  Class B..........................................................          10           30           53          117
Global Fixed Income
  Class A..........................................................           5           16           28           63
  Class B..........................................................           7           21           36           81
High Yield Portfolio
  Class A..........................................................           7           22           38           86
  Class B..........................................................          10           30           52          115
</TABLE>
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. ACTUAL EXPENSES MAY BE GREATER OR LESS THAN THOSE
SHOWN.
 
                                       3
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following tables provide financial highlights for the Class A and Class
B shares for each of the Portfolios for the periods presented. The audited
financial highlights for each of the Portfolio's shares for each of the periods
in the five years ended December 31, 1997 are part of the Fund's financial
statements which appear in the Fund's December 31, 1997 Annual Report to
Shareholders and which are incorporated by reference into the Fund's Statement
of Additional Information. Each Portfolio's financial highlights for each of the
periods presented have been audited by Price Waterhouse LLP, whose unqualified
report thereon is also incorporated by reference into the Statement of
Additional Information. Additional performance information is included in the
Annual Report. The Annual Report and the financial statements therein, along
with the Statement of Additional Information, are available at no cost from the
Fund at the address and telephone number noted on the cover page of this
Prospectus. After October 31, 1992, the Fund changed its fiscal year end to
December 31. The following information should be read in conjunction with the
financial statements and notes thereto.
 
                                       4
<PAGE>
                        SMALL CAP VALUE EQUITY PORTFOLIO
<TABLE>
<CAPTION>
                                                                   CLASS A
                                          ---------------------------------------------------------
 
                                                           YEAR ENDED DECEMBER 31,
                                          ---------------------------------------------------------
                                              1997           1996           1995           1994
                                          ------------   ------------   ------------   ------------
<S>                                       <C>            <C>            <C>            <C>
NET ASSET VALUE, BEGINNING OF PERIOD....    $ 10.89        $ 11.91        $ 10.80        $ 11.10
                                          ------------   ------------   ------------   ------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1).............       0.07           0.32           0.30           0.28
  Net Realized and Unrealized Gain
   (Loss) on Investments................       3.72           2.36           1.82         (0.01)
                                          ------------   ------------   ------------   ------------
    Total from Investment Operations....       3.79           2.68           2.12           0.27
                                          ------------   ------------   ------------   ------------
DISTRIBUTIONS
  Net Investment Income.................     (0.08)         (0.32)         (0.38)         (0.27)
  In Excess of Net Investment Income....     (0.00)+            --             --             --
  Net Realized Gain.....................     (3.36)         (3.38)         (0.63)         (0.30)
                                          ------------   ------------   ------------   ------------
    Total Distributions.................     (3.44)         (3.70)         (1.01)         (0.57)
                                          ------------   ------------   ------------   ------------
NET ASSET VALUE, END OF PERIOD..........    $ 11.24        $ 10.89        $ 11.91        $ 10.80
                                          ------------   ------------   ------------   ------------
                                          ------------   ------------   ------------   ------------
TOTAL RETURN............................      36.80%         22.99%         20.63%          2.53%
                                          ------------   ------------   ------------   ------------
                                          ------------   ------------   ------------   ------------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)..........................    $35,612        $23,970        $51,919        $40,033
  Ratio of Expenses to Average Net
   Assets (1)...........................       1.01%          1.00%          1.00%          1.00%
  Ratio of Expenses to Average Net
   Assets Excluding Interest Expense....       1.00%          1.00%          1.00%          1.00%
  Ratio of Net Investment Income to
   Average Net Assets (1)...............       0.55%          2.20%          2.60%          2.67%
  Portfolio Turnover Rate...............        178%            32%            36%            22%
  Average Commission Rate Per Share#....    $0.0500        $0.0402            N/A            N/A
- -------------------------
(1) Effect of voluntary expense
    limitation during the period:
     Per share benefit to net investment
      income............................    $  0.04        $  0.04        $  0.02        $  0.03
   Ratios before expense limitation:
     Expenses to Average Net Assets.....       1.32%          1.32%          1.21%          1.26%
     Net Investment Income to Average
      Net Assets........................       0.24%          1.89%          2.39%          2.41%
 
<CAPTION>
                                                                                  CLASS B
                                                                        ---------------------------
                                                         PERIOD FROM                   PERIOD FROM
                                                         DECEMBER 17,                   JANUARY 2,
                                                           1992* TO      YEAR ENDED     1996*** TO
                                                         DECEMBER 31,   DECEMBER 31,   DECEMBER 31,
                                              1993           1992           1997           1996
                                          ------------   ------------   ------------   ------------
<S>                                       <C>            <C>            <C>            <C>
NET ASSET VALUE, BEGINNING OF PERIOD....    $ 10.14        $ 10.00        $ 10.88        $ 11.95
                                          ------------   ------------   ------------   ------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1).............       0.24           0.01           0.10           0.23
  Net Realized and Unrealized Gain
   (Loss) on Investments................       0.90           0.13           3.65           2.38
                                          ------------   ------------   ------------   ------------
    Total from Investment Operations....       1.14           0.14           3.75           2.61
                                          ------------   ------------   ------------   ------------
DISTRIBUTIONS
  Net Investment Income.................     (0.18)             --         (0.06)         (0.30)
  In Excess of Net Investment Income....         --             --         (0.00)+            --
  Net Realized Gain.....................         --             --         (3.36)         (3.38)
                                          ------------   ------------   ------------   ------------
    Total Distributions.................     (0.18)             --         (3.42)         (3.68)
                                          ------------   ------------   ------------   ------------
NET ASSET VALUE, END OF PERIOD..........    $ 11.10        $ 10.14        $ 11.21        $ 10.88
                                          ------------   ------------   ------------   ------------
                                          ------------   ------------   ------------   ------------
TOTAL RETURN............................      11.33%          1.40%         36.51%         22.33%
                                          ------------   ------------   ------------   ------------
                                          ------------   ------------   ------------   ------------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)..........................    $26,775        $ 5,974        $ 7,523        $ 1,689
  Ratio of Expenses to Average Net
   Assets (1)...........................       1.00%          1.00%**        1.26%          1.24%**
  Ratio of Expenses to Average Net
   Assets Excluding Interest Expense....       1.00%          1.00%**        1.25%          1.24%**
  Ratio of Net Investment Income to
   Average Net Assets (1)...............       2.56%          1.64%**       (0.06)%         1.93%**
  Portfolio Turnover Rate...............         29%             0%           178%            32%
  Average Commission Rate Per Share#....        N/A            N/A        $0.0500        $0.0402
- -------------------------
(1) Effect of voluntary expense
    limitation during the period:
     Per share benefit to net investment
      income............................    $  0.06        $  0.13        $  0.02        $  0.05
   Ratios before expense limitation:
     Expenses to Average Net Assets.....       1.68%         23.14%**        1.56%          1.69%**
     Net Investment Income to Average
      Net Assets........................       1.88%        (20.50)%**      (0.36)%         1.50%**
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period.
 
  + Amount is less than $0.01 per share.
 
                                       5
<PAGE>
                             VALUE EQUITY PORTFOLIO
<TABLE>
<CAPTION>
                                                           CLASS A
                              -----------------------------------------------------------------
 
                                                   YEAR ENDED DECEMBER 31,
                              -----------------------------------------------------------------
                                 1997          1996          1995          1994         1993
                              -----------   -----------   -----------   ----------   ----------
<S>                           <C>           <C>           <C>           <C>          <C>
NET ASSET VALUE, BEGINNING
 OF PERIOD..................    $   13.89     $   13.94     $   11.50     $  12.63     $  11.31
                              -----------   -----------   -----------   ----------   ----------
INCOME FROM INVESTMENT
 OPERATIONS
Net Investment Income (1)...         0.35          0.41          0.38         0.40         0.37
Net Realized and Unrealized
 Gain (Loss) on
 Investments................         3.51          2.27          3.30       (0.55)         1.31
                              -----------   -----------   -----------   ----------   ----------
    Total from Investment
     Operations.............         3.86          2.68          3.68       (0.15)         1.68
                              -----------   -----------   -----------   ----------   ----------
DISTRIBUTIONS
  Net Investment Income.....       (0.35)        (0.41)        (0.47)       (0.40)       (0.36)
  Net Realized Gain.........       (3.78)        (2.32)        (0.77)       (0.58)           --
                              -----------   -----------   -----------   ----------   ----------
    Total Distributions.....       (4.13)        (2.73)        (1.24)       (0.98)       (0.36)
                              -----------   -----------   -----------   ----------   ----------
NET ASSET VALUE, END OF
 PERIOD.....................    $   13.62     $   13.89     $   13.94     $  11.50     $  12.63
                              -----------   -----------   -----------   ----------   ----------
                              -----------   -----------   -----------   ----------   ----------
TOTAL RETURN................        29.20%        19.73%        33.69%       (1.29)%      15.14%
                              -----------   -----------   -----------   ----------   ----------
                              -----------   -----------   -----------   ----------   ----------
RATIOS AND SUPPLEMENTAL
 DATA:
  Net Assets, End of Period
   (Thousands)..............    $  86,054     $ 106,128     $ 147,365     $ 73,406     $ 54,598
  Ratio of Expenses to
   Average Net Assets (1)...         0.70%         0.70%         0.70%        0.70%        0.70%
  Ratio of Net Investment
   Income to Average Net
   Assets (1)...............         2.15%         2.62%         3.01%        3.37%        3.23%
  Portfolio Turnover Rate...           36%           42%           43%          33%          51%
  Average Commission Rate
   Per Share#...............      $0.0411       $0.0434           N/A          N/A          N/A
- -------------------------
(1) Effect of voluntary
    expense limitation
    during the period:
     Per share benefit to
      net investment
      income................        $0.02         $0.01         $0.01        $0.01        $0.03
   Ratios before expense
    limitation:
     Expenses to Average Net
      Assets................         0.80%         0.78%         0.77%        0.80%        0.95%
     Net Investment Income
      to
      Average Net Assets....         2.06%         2.55%         2.94%        3.27%        2.98%
 
<CAPTION>
                                                                                          CLASS B
                                                                                  ------------------------
                                                                                                  PERIOD
                                                                                                   FROM
                              TWO MONTHS   YEAR ENDED OCTOBER 31,     JAN. 31*                   JAN. 2,
                                ENDED                                    TO       YEAR ENDED    1996*** TO
                               DEC. 31,    -----------------------    DEC. 31,     DEC. 31,      DEC. 31,
                                 1992         1992         1991         1990         1997          1996
                              ----------   ----------   ----------   ----------   -----------   ----------
<S>                           <C>          <C>          <C>          <C>          <C>           <C>
NET ASSET VALUE, BEGINNING
 OF PERIOD..................    $  10.71     $  10.24     $   8.59     $ 10.00      $   13.89     $ 14.06
                              ----------   ----------   ----------   ----------   -----------   ----------
INCOME FROM INVESTMENT
 OPERATIONS
Net Investment Income (1)...        0.08         0.38         0.46        0.37           0.28        0.29
Net Realized and Unrealized
 Gain (Loss) on
 Investments................        0.52         0.48         1.67      (1.45)           3.51        2.25
                              ----------   ----------   ----------   ----------   -----------   ----------
    Total from Investment
     Operations.............        0.60         0.86         2.13      (1.08)           3.79        2.54
                              ----------   ----------   ----------   ----------   -----------   ----------
DISTRIBUTIONS
  Net Investment Income.....          --       (0.39)       (0.48)      (0.33)         (0.31)      (0.39)
  Net Realized Gain.........          --           --           --          --         (3.78)      (2.32)
                              ----------   ----------   ----------   ----------   -----------   ----------
    Total Distributions.....          --       (0.39)       (0.48)      (0.33)         (4.09)      (2.71)
                              ----------   ----------   ----------   ----------   -----------   ----------
NET ASSET VALUE, END OF
 PERIOD.....................    $  11.31     $  10.71     $  10.24     $  8.59      $   13.59     $ 13.89
                              ----------   ----------   ----------   ----------   -----------   ----------
                              ----------   ----------   ----------   ----------   -----------   ----------
TOTAL RETURN................        5.60%        8.51%       25.34%     (11.05)%        28.70%      18.57%
                              ----------   ----------   ----------   ----------   -----------   ----------
                              ----------   ----------   ----------   ----------   -----------   ----------
RATIOS AND SUPPLEMENTAL
 DATA:
  Net Assets, End of Period
   (Thousands)..............    $ 27,541     $ 25,013     $ 16,304     $18,178      $   2,246     $ 2,555
  Ratio of Expenses to
   Average Net Assets (1)...        0.70%**       0.70%       0.70%       0.70%**        0.95%       0.95%**
  Ratio of Net Investment
   Income to Average Net
   Assets (1)...............        4.41%**       3.72%       4.57%       5.46%**        1.86%       2.33%**
  Portfolio Turnover Rate...           9%          56%          90%         70%            36%         42%
  Average Commission Rate
   Per Share#...............         N/A          N/A          N/A         N/A        $0.0411     $0.0434
- -------------------------
(1) Effect of voluntary
    expense limitation
    during the period:
     Per share benefit to
      net investment
      income................       $0.01        $0.01        $0.02       $0.01          $0.01       $0.01
   Ratios before expense
    limitation:
     Expenses to Average Net
      Assets................        1.20%**       0.84%       0.87%       0.88%**        1.04%       1.03%**
     Net Investment Income
      to
      Average Net Assets....        3.91%**       3.58%       4.40%       5.28%**        1.77%       2.26%**
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were paid, during the period.
 
                                       6
<PAGE>
                               BALANCED PORTFOLIO
<TABLE>
<CAPTION>
                                                           CLASS A
                                --------------------------------------------------------------
                                                   YEAR ENDED DECEMBER 31,
                                --------------------------------------------------------------
                                   1997         1996         1995         1994         1993
                                ----------   ----------   ----------   ----------   ----------
<S>                             <C>          <C>          <C>          <C>          <C>
NET ASSET VALUE, BEGINNING OF
 PERIOD.......................  $  8.19      $  9.98      $  8.96      $ 11.13      $ 11.31
                                ----------   ----------   ----------   ----------   ----------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Income (1)...     0.36         0.52         0.39         0.42         0.44
  Net Realized and Unrealized
   Gain (Loss) on
   Investments................     0.99         0.54         1.62       (0.64)         0.79
                                ----------   ----------   ----------   ----------   ----------
    Total from Investment
     Operations...............     1.35         1.06         2.01       (0.22)         1.23
                                ----------   ----------   ----------   ----------   ----------
DISTRIBUTIONS
  Net Investment Income.......   (0.36)       (0.48)       (0.50)       (0.49)       (0.41)
  In Excess of Net Investment
   Income.....................   (0.00)+        0.00+          --           --       (0.08)
  Net Realized Gain...........   (1.63)       (2.37)       (0.49)       (1.46)       (0.06)
  In Excess of Net Realized
   Gain.......................       --           --           --           --       (0.86)
                                ----------   ----------   ----------   ----------   ----------
    Total Distributions.......   (1.99)       (2.85)       (0.99)       (1.95)       (1.41)
                                ----------   ----------   ----------   ----------   ----------
NET ASSET VALUE, END OF
 PERIOD.......................  $  7.55      $  8.19      $  9.98      $  8.96      $ 11.13
                                ----------   ----------   ----------   ----------   ----------
                                ----------   ----------   ----------   ----------   ----------
TOTAL RETURN..................    17.30%       10.93%       23.63%       (2.32)%      12.09%
                                ----------   ----------   ----------   ----------   ----------
                                ----------   ----------   ----------   ----------   ----------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)................  $ 4,606      $ 5,992      $22,642      $18,492      $29,684
  Ratio of Expenses to Average
   Net Assets (1).............     0.71%        0.70%        0.70%        0.70%        0.70%
  Ratio of Expenses to Average
   Net Assets Excluding
   Interest Expense...........     0.70%        0.70%        0.70%        0.70%        0.70%
  Ratio of Net Investment
   Income to Average Net
   Assets (1).................     3.82%        3.93%        4.10%        4.13%        3.88%
  Portfolio Turnover Rate.....       25%          22%          26%          44%         136%
  Average Commission Rate Per
   Share#.....................  $0.0426      $0.0397          N/A          N/A          N/A
- ----------------------
(1) Effect of voluntary
    expense limitation during
    the period:
     Per share benefit to net
      investment income.......    $0.11        $0.08        $0.03        $0.03        $0.04
   Ratios before expense
    limitation:
     Expenses to Average Net
      Assets..................     1.83%        1.32%        1.02%        0.95%        1.02%
     Net Investment Income to
      Average Net Assets......     2.71%        3.31%        3.78%        3.88%        3.56%
 
<CAPTION>
                                                                                                CLASS B
                                                                                        -----------------------
                                                                                                       PERIOD
                                                                                                        FROM
                                   TWO                                                                 JAN. 2,
                                 MONTHS       YEAR ENDED OCTOBER 31,      FEB. 20*        YEAR         1996***
                                  ENDED                                      TO           ENDED          TO
                                DEC. 31,      -----------------------     OCT. 31,      DEC. 31,      DEC. 31,
                                  1992          1992          1991          1990          1997          1996
                                ---------     ---------     ---------     ---------     ---------     ---------
<S>                             <C>           <C>           <C>           <C>           <C>           <C>
NET ASSET VALUE, BEGINNING OF
 PERIOD.......................  $ 11.00       $   10.61     $    9.62     $ 10.00       $  8.18       $ 10.02
                                ---------     ---------     ---------     ---------     ---------     ---------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Income (1)...     0.10            0.58          0.59        0.40          0.08          0.34
  Net Realized and Unrealized
   Gain (Loss) on
   Investments................     0.21            0.42          1.03      (0.46)          1.24          0.65
                                ---------     ---------     ---------     ---------     ---------     ---------
    Total from Investment
     Operations...............     0.31            1.00          1.62      (0.06)          1.32          0.99
                                ---------     ---------     ---------     ---------     ---------     ---------
DISTRIBUTIONS
  Net Investment Income.......       --          (0.58)        (0.63)      (0.32)        (0.34)        (0.46)
  In Excess of Net Investment
   Income.....................       --              --            --          --            --            --
  Net Realized Gain...........       --          (0.03)            --          --        (1.63)        (2.37)
  In Excess of Net Realized
   Gain.......................       --              --            --          --            --            --
                                ---------     ---------     ---------     ---------     ---------     ---------
    Total Distributions.......       --          (0.61)        (0.63)      (0.32)        (1.97)        (2.83)
                                ---------     ---------     ---------     ---------     ---------     ---------
NET ASSET VALUE, END OF
 PERIOD.......................  $ 11.31       $   11.00     $   10.61     $  9.62       $  7.53       $  8.18
                                ---------     ---------     ---------     ---------     ---------     ---------
                                ---------     ---------     ---------     ---------     ---------     ---------
TOTAL RETURN..................     2.82%           9.57%        17.31%      (0.63)%       16.94%        10.24%
                                ---------     ---------     ---------     ---------     ---------     ---------
                                ---------     ---------     ---------     ---------     ---------     ---------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)................  $39,984       $  40,332     $  51,334     $37,444       $   621       $ 2,197
  Ratio of Expenses to Average
   Net Assets (1).............     0.70%**         0.70%         0.70%       0.70%**       0.96%         0.95%**
  Ratio of Expenses to Average
   Net Assets Excluding
   Interest Expense...........     0.70%           0.70%         0.70%       0.70%**       0.95%         0.95%**
  Ratio of Net Investment
   Income to Average Net
   Assets (1).................     5.29%**         5.21%         5.99%       6.81%**       3.60%         3.73%**
  Portfolio Turnover Rate.....        4%             40%           67%         19%           25%           22%
  Average Commission Rate Per
   Share#.....................      N/A             N/A           N/A         N/A       $0.0426       $0.0397
- ----------------------
(1) Effect of voluntary
    expense limitation during
    the period:
     Per share benefit to net
      investment income.......    $0.01           $0.01         $0.01       $0.01         $0.14         $0.07
   Ratios before expense
    limitation:
     Expenses to Average Net
      Assets..................     1.00%**         0.79%         0.78%       0.90%**       2.05%        1.68%**
     Net Investment Income to
      Average Net Assets......     4.99%**         5.12%         5.91%       6.61%**       2.50%        3.00%**
</TABLE>
 
- --------------------------------------------------------------------------------
 
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
  + Amount is less than $0.01 per share.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period.
 
                                       7
<PAGE>
                         GLOBAL FIXED INCOME PORTFOLIO
<TABLE>
<CAPTION>
                                                               CLASS A
                                          -------------------------------------------------
 
                                                       YEAR ENDED DECEMBER 31,
                                          -------------------------------------------------
                                            1997++        1996         1995         1994
                                          ----------   ----------   ----------   ----------
<S>                                       <C>          <C>          <C>          <C>
NET ASSET VALUE, BEGINNING OF PERIOD....  $  11.30     $    11.22   $    10.29   $    11.68
                                          ----------   ----------   ----------   ----------
INCOME FROM INVESTMENT OPERATIONS
Net Investment Income (1)...............      0.56           0.61         0.76         0.70
Net Realized and Unrealized Gain (Loss)
 on Investments.........................    (0.40)           0.08         1.15       (1.38)
                                          ----------   ----------   ----------   ----------
    Total from Investment Operations....      0.16           0.69         1.91       (0.68)
                                          ----------   ----------   ----------   ----------
DISTRIBUTIONS
  Net Investment Income.................    (0.31)         (0.61)       (0.98)       (0.40)
  In Excess of Net Investment Income....        --             --           --           --
  Net Realized Gain.....................        --             --           --       (0.31)
                                          ----------   ----------   ----------   ----------
    Total Distributions.................    (0.31)         (0.61)       (0.98)       (0.71)
                                          ----------   ----------   ----------   ----------
NET ASSET VALUE, END OF PERIOD..........  $  11.15     $    11.30   $    11.22   $    10.29
                                          ----------   ----------   ----------   ----------
                                          ----------   ----------   ----------   ----------
TOTAL RETURN............................      1.50%          6.44%       19.32%       (6.08)%
                                          ----------   ----------   ----------   ----------
                                          ----------   ----------   ----------   ----------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)..........................  $ 84,635     $  112,888   $  102,852   $  130,675
  Ratio of Expenses to Average Net
   Assets (1)...........................      0.50%          0.50%        0.50%        0.50%
  Ratio of Net Investment Income to
   Average Net Assets (1)...............      5.05%          5.50%        6.79%        6.34%
  Portfolio Turnover Rate...............       116%           258%         207%         171%
- ----------------------
(1) Effect of voluntary expense
    limitation during the period:
     Per share benefit to net investment
      income............................     $0.02          $0.02        $0.02        $0.02
   Ratios before expense limitation:
     Expenses to Average Net Assets.....      0.71%          0.72%        0.71%        0.66%
     Net Investment Income to Average
      Net Assets........................      4.84%          5.29%        6.58%        6.18%
 
<CAPTION>
                                                                                                       CLASS B
                                                                                              -------------------------
                                                                                                           PERIOD FROM
                                                       TWO MONTHS                                            JAN. 2,
                                                         ENDED      YEAR ENDED   MAY 1* TO    YEAR ENDED    1996*** TO
                                                        DEC. 31,     OCT. 31,     OCT. 31,     DEC. 31,      DEC. 31,
                                             1993         1992         1992         1991        1997++         1996
                                          ----------   ----------   ----------   ----------   ----------   ------------
<S>                                       <C>          <C>          <C>          <C>          <C>          <C>
NET ASSET VALUE, BEGINNING OF PERIOD....  $    11.26   $  11.41     $    10.61   $    10.00   $  11.29         $11.23
                                          ----------   ----------   ----------   ----------   ----------       ------
INCOME FROM INVESTMENT OPERATIONS
Net Investment Income (1)...............        0.69       0.14           0.53         0.16       0.54           0.48
Net Realized and Unrealized Gain (Loss)
 on Investments.........................        0.90     (0.29)           0.55         0.45     (0.40)           0.18
                                          ----------   ----------   ----------   ----------   ----------       ------
    Total from Investment Operations....        1.59     (0.15)           1.08         0.61       0.14           0.66
                                          ----------   ----------   ----------   ----------   ----------       ------
DISTRIBUTIONS
  Net Investment Income.................      (0.79)         --         (0.27)           --     (0.30)         (0.60)
  In Excess of Net Investment Income....      (0.22)         --             --           --         --             --
  Net Realized Gain.....................      (0.16)         --         (0.01)           --         --             --
                                          ----------   ----------   ----------   ----------   ----------       ------
    Total Distributions.................      (1.17)         --         (0.28)           --     (0.30)         (0.60)
                                          ----------   ----------   ----------   ----------   ----------       ------
NET ASSET VALUE, END OF PERIOD..........  $    11.68   $  11.26     $    11.41   $    10.61   $  11.13         $11.29
                                          ----------   ----------   ----------   ----------   ----------       ------
                                          ----------   ----------   ----------   ----------   ----------       ------
TOTAL RETURN............................       15.34%     (1.31)%        10.29%         6.1%      1.29%          6.12%
                                          ----------   ----------   ----------   ----------   ----------       ------
                                          ----------   ----------   ----------   ----------   ----------       ------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)..........................  $  172,468   $ 92,897     $   94,847   $   28,236   $    366         $1,559
  Ratio of Expenses to Average Net
   Assets (1)...........................        0.50%      0.50%**        0.50%        0.50%**     0.65%         0.65%**
  Ratio of Net Investment Income to
   Average Net Assets (1)...............        5.99%      6.99%**        6.92%        7.24%**     4.88%         5.28%**
  Portfolio Turnover Rate...............         108%         9%           144%          20%       116%           258%
- ----------------------
(1) Effect of voluntary expense
    limitation during the period:
     Per share benefit to net investment
      income............................       $0.02      $0.01          $0.03        $0.02      $0.02          $0.02
   Ratios before expense limitation:
     Expenses to Average Net Assets.....        0.70%      0.90%**        0.86%        1.62%**     0.86%         0.86%**
     Net Investment Income to Average
      Net Assets........................        5.79%      6.59%**        6.56%        6.12%**     4.68%         5.08%**
</TABLE>
 
- --------------------------------------------------------------------------------
 
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
 ++ Per share amounts for the period ended December 31, 1997 are based on
    average shares outstanding.
 
                                       8
<PAGE>
                              HIGH YIELD PORTFOLIO
<TABLE>
<CAPTION>
                                                     CLASS A
                                -------------------------------------------------
 
                                             YEAR ENDED DECEMBER 31,
                                -------------------------------------------------
                                   1997         1996         1995         1994
                                ----------   ----------   ----------   ----------
<S>                             <C>          <C>          <C>          <C>
NET ASSET VALUE, BEGINNING OF
 PERIOD.......................  $    10.91   $  10.46     $   9.55     $  11.16
                                ----------   ----------   ----------   ----------
INCOME FROM INVESTMENT
 OPERATIONS
Net Investment Income (1).....        1.00       1.03         1.14         0.97
  Net Realized and Unrealized
   Gain (Loss) on
   Investments................        0.67       0.47         0.97       (1.40)
                                ----------   ----------   ----------   ----------
    Total from Investment
     Operations...............        1.67       1.50         2.11       (0.43)
                                ----------   ----------   ----------   ----------
DISTRIBUTIONS
  Net Investment Income.......      (1.00)     (1.05)       (1.20)       (0.97)
  In Excess of Net Investment
   Income.....................          --     (0.00)+          --           --
  Net Realized Gain...........          --         --           --       (0.21)
                                ----------   ----------   ----------   ----------
    Total Distributions.......      (1.00)     (1.05)       (1.20)       (1.18)
                                ----------   ----------   ----------   ----------
NET ASSET VALUE, END OF
 PERIOD.......................  $    11.58   $  10.91     $  10.46     $   9.55
                                ----------   ----------   ----------   ----------
                                ----------   ----------   ----------   ----------
TOTAL RETURN..................       15.87%     15.01%       23.35%       (4.18)%
                                ----------   ----------   ----------   ----------
                                ----------   ----------   ----------   ----------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)................  $  113,006   $ 95,663     $ 62,245     $ 97,223
  Ratio of Expenses to Average
   Net Assets (1).............        0.69%      0.75%        0.75%        0.75%
  Ratio of Net Investment
   Income to Average Net
   Assets (1).................        8.70%      9.78%       11.09%        9.42%
  Portfolio Turnover Rate.....         111%       117%          90%          74%
- ----------------------
(1) Effect of voluntary
    expense limitation during
    the period:
     Per share benefit to net
      investment income.......         N/A      $0.01        $0.01       $0.001
   Ratios before expense
    limitation:
     Expenses to Average Net
      Assets..................         N/A       0.82%        0.83%        0.76%
     Net Investment Income to
      Average Net Assets......         N/A       9.71%       11.01%        9.41%
 
<CAPTION>
                                                                               CLASS B
                                                                       -----------------------
                                                            PERIOD                    PERIOD
                                                             FROM                      FROM
                                             TWO MONTHS   SEPT. 28,                  JAN. 2,
                                               ENDED       1992* TO    YEAR ENDED   1996*** TO
                                              DEC. 31,     OCT. 31,     DEC. 31,     DEC. 31,
                                   1993         1992         1992         1997         1996
                                ----------   ----------   ----------   ----------   ----------
<S>                             <C>          <C>          <C>          <C>          <C>
NET ASSET VALUE, BEGINNING OF
 PERIOD.......................  $   9.95     $   9.77     $  10.00     $  10.90     $  10.49
                                ----------   ----------   ----------   ----------   ----------
INCOME FROM INVESTMENT
 OPERATIONS
Net Investment Income (1).....      0.90         0.14         0.08         0.97         0.98
  Net Realized and Unrealized
   Gain (Loss) on
   Investments................      1.21         0.19       (0.31)         0.65         0.45
                                ----------   ----------   ----------   ----------   ----------
    Total from Investment
     Operations...............      2.11         0.33       (0.23)         1.62         1.43
                                ----------   ----------   ----------   ----------   ----------
DISTRIBUTIONS
  Net Investment Income.......    (0.90)       (0.15)           --       (0.96)       (1.02)
  In Excess of Net Investment
   Income.....................        --           --           --           --           --
  Net Realized Gain...........        --           --           --           --           --
                                ----------   ----------   ----------   ----------   ----------
    Total Distributions.......    (0.90)       (0.15)           --       (0.96)       (1.02)
                                ----------   ----------   ----------   ----------   ----------
NET ASSET VALUE, END OF
 PERIOD.......................  $  11.16     $   9.95     $   9.77     $  11.56     $  10.90
                                ----------   ----------   ----------   ----------   ----------
                                ----------   ----------   ----------   ----------   ----------
TOTAL RETURN..................     22.11%        3.41%       (2.30)%      15.48%       14.37%
                                ----------   ----------   ----------   ----------   ----------
                                ----------   ----------   ----------   ----------   ----------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)................  $ 74,500     $ 20,194     $ 16,950     $  7,213     $  5,665
  Ratio of Expenses to Average
   Net Assets (1).............      0.75%        0.75%**      0.75%**      0.93%        1.00%**
  Ratio of Net Investment
   Income to Average Net
   Assets (1).................      8.70%        8.96%**      9.89%**      8.48%        9.49%**
  Portfolio Turnover Rate.....       104%          24%           9%         111%         117%
- ----------------------
(1) Effect of voluntary
    expense limitation during
    the period:
     Per share benefit to net
      investment income.......     $0.02        $0.01        $0.01          N/A        $0.01
   Ratios before expense
    limitation:
     Expenses to Average Net
      Assets..................      0.96%        1.62%**      1.23%**       N/A         1.05%**
     Net Investment Income to
      Average Net Assets......      8.49%        8.09%**      9.41%**       N/A         9.44%**
</TABLE>
 
- --------------------------------------------------------------------------------
 
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
  + Amount is less than $0.01 per share.
 
                                       9
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and high net worth individual investors a broad range of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates providing customized services as Adviser, Administrator and
Distributor. Each portfolio offers Class A shares and Class B shares, except for
the International Small Cap and Municipal Money Market Portfolios which offer
only Class A shares. Each portfolio has its own investment objective and
policies designed to meet its specific goals. The investment objective of each
Portfolio described in this Prospectus is as follows:
 
    - The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total return by
      investing in equity securities of small- to medium-sized companies which
      the Adviser believes to be undervalued.
 
    - The VALUE EQUITY PORTFOLIO seeks high total return by investing in equity
      securities which the Adviser believes to be undervalued relative to the
      stock market in general at the time of purchase.
 
    - The BALANCED PORTFOLIO seeks high total return while preserving capital by
      investing in a combination of equity securities which the Adviser believes
      to be undervalued and fixed income securities.
 
    - The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
      of return while preserving capital by investing in fixed income securities
      of issuers throughout the world, including U.S. issuers.
 
    - The HIGH YIELD PORTFOLIO seeks to maximize total return by investing in a
      diversified portfolio of high yield fixed income securities that offer a
      yield above that generally available on debt securities in the four
      highest rating categories of the recognized rating services.
 
    The other portfolios of the Fund are described in other prospectuses which
may be obtained from the Fund at the address and phone number noted on the cover
page of this Prospectus. The investment objectives of these other portfolios are
listed below:
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    - The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
      appreciation by investing in accordance with country weightings determined
      by the Adviser in equity securities of non-U.S. issuers which, in the
      aggregate, replicate broad country indices.
 
    - The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of Asian issuers.
 
    - The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
      appreciation by investing primarily in equity securities of companies in
      the Asian real estate industry.
 
    - The CHINA GROWTH PORTFOLIO seeks to provide long-term capital appreciation
      by investing primarily in equity securities of issuers in The People's
      Republic of China, Hong Kong and Taiwan.
 
    - The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of emerging country issuers.
 
    - The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of European issuers.
 
                                       10
<PAGE>
    - The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income and
      long-term capital appreciation by investing primarily in equity securities
      in the European real estate industry.
 
    - The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of issuers throughout the world,
      including U.S. issuers.
 
    - The GOLD PORTFOLIO seeks long-term capital appreciation by investing
      primarily in equity securities of foreign and domestic issuers engaged in
      gold-related activities.
 
    - The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of non-U.S. issuers.
 
    - The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of non-U.S. issuers domiciled in
      EAFE countries.
 
    - The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
      by investing primarily in equity securities of non-U.S. issuers with
      equity market capitalizations of less than $1 billion.
 
    - The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of Japanese issuers.
 
    - The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of Latin American issuers and,
      from time to time, debt securities issued or guaranteed by Latin American
      governments or governmental entities.
 
    U.S. EQUITY:
 
    - The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by investing
      primarily in corporate equity and equity-linked securities.
 
    - The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation by
      investing primarily in growth-oriented equity securities of small- to
      medium-sized corporations.
 
    - The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
      investing in growth-oriented equity securities of medium and large
      capitalization companies.
 
    - The MICROCAP PORTFOLIO seeks long-term capital appreciation by investing
      primarily in growth-oriented equity securities of small corporations.
 
    - The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by investing
      primarily in equity securities of companies that, in the opinion of the
      Adviser, are expected to benefit from their involvement in technology and
      technology-related industries.
 
    - The U.S. EQUITY PLUS PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of issuers included in the
      Standard & Poor's 500 Index ("S&P 500").
 
    - The U.S. REAL ESTATE PORTFOLIO seeks to provide above-average current
      income and long-term capital appreciation by investing primarily in equity
      securities of companies in the U.S. real estate industry, including
      substantial investment in real estate investment trusts.
 
    FIXED INCOME:
 
    - The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by investing
      primarily in debt securities of government, government-related and
      corporate issuers located in emerging countries.
 
                                       11
<PAGE>
    - The FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
      with the preservation of capital by investing in a diversified portfolio
      of fixed income securities.
 
    - The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a level
      of current income as is consistent with the preservation of capital by
      investing primarily in a variety of investment grade mortgage-backed
      securities.
 
    - The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of current
      income consistent with preservation of principal by investing in municipal
      obligations, the interest on which is exempt from federal income tax.
 
    MONEY MARKET:
 
    - The MONEY MARKET PORTFOLIO seeks to maximize current income and preserve
      capital while maintaining high levels of liquidity through investing in
      high quality money market instruments with remaining maturities of one
      year or less.
 
    - The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current tax-exempt
      income and preserve capital while maintaining high levels of liquidity
      through investing in high quality money market instruments with remaining
      maturities of one year or less which are exempt from federal income tax.
 
    THE CHINA GROWTH, GOLD, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS
    ARE CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley Dean Witter & Co., acts as investment adviser to the Fund and each of
its portfolios. As of March 31, 1998, Morgan Stanley Asset Management Inc. and
its affiliated institutional asset management companies managed assets of
approximately $166 billion, including assets under fiduciary advice. See
"Management of the Fund -- Investment Adviser" and "Management of the Fund --
Administrator."
 
HOW TO INVEST
 
    Class A shares of each Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of each
Portfolio are offered at net asset value with no sales commission, but with a
12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25% of the
Class B shares' average daily net assets on an annualized basis. The Distributor
has agreed to waive 0.10% of the 0.25% 12b-1 fee with respect to the Global
Fixed Income Portfolio. The minimum initial investment, generally, is $500,000
for Class A shares of each Portfolio and $100,000 for Class B shares of each
Portfolio. The minimum initial investment amount is reduced for certain
categories of investors. For additional information on how to purchase shares
and minimum initial investments, see "Purchase of Shares."
 
HOW TO REDEEM
 
    Class A shares or Class B shares of each Portfolio may be redeemed at any
time, without cost, at the net asset value per share of the applicable class
next determined after receipt of the redemption request. The redemption price
may be more or less than the purchase price. Certain redemptions that cause the
value of an account to remain for a continuous 60-day period below the minimum
investment amount for Class A shares or
 
                                       12
<PAGE>
for Class B shares may result in involuntary redemption or automatic conversion.
For additional information on how to redeem shares and involuntary redemption or
conversion, see "Purchase of Shares" and "Redemption of Shares."
 
RISK FACTORS
 
    Investing in each of the Portfolios entails certain risks and considerations
of which an investor should be aware. The Portfolios' share prices and
investment returns fluctuate and, when redeemed, an investment in the Portfolios
may be worth more or less than its original cost. The investment policies of the
Portfolios may entail the following risk factors:
 
    - EQUITY SECURITIES. The Small Cap Value Equity, Value Equity and Balanced
      Portfolios invest primarily in equity securities. Prices of equity
      securities fluctuate in response to many factors, including the financial
      health of the issuer and changes in economic and market conditions.
 
    - FIXED INCOME SECURITIES. The Balanced, Global Fixed Income and High Yield
      Portfolios will be subject to credit risk and market risk associated with
      investment in fixed income securities. Credit risk is the possibility that
      an issuer may be unable to meet scheduled principal and interest payments.
      Market risk is the possibility that a change in interest rates or the
      market's perception of the issuer's prospects may adversely affect the
      value of a fixed income security.
 
    - HIGH YIELD SECURITIES. The High Yield Portfolio may invest in lower rated
      and unrated fixed income securities (i.e., high yield or high risk
      securities), which are often issued by smaller or less creditworthy
      companies. High yield securities generally are subject to greater market
      risk and credit risk than other fixed income securities.
 
    - MORTGAGE-BACKED SECURITIES. The Balanced and High Yield Portfolios may
      invest in mortgage-backed securities. Mortgage-backed securities represent
      an interest in a pool of underlying mortgage loans. They are sensitive to
      changes in interest rates, but may respond to these changes in a manner
      different from other fixed income securities due to the possiblity of
      prepayment of the underlying mortgage loans. As a result, it is not
      possible to determine in advance the actual maturity date or average life
      of a mortgage-backed security. Rising interest rates tend to discourage
      refinancings, with the result that the average life and volatility of the
      security will increase and its market price will decrease. When interest
      rates fall, mortgage-backed securities may not gain as much in market
      value because additional mortgage prepayments must be reinvested at lower
      interest rates.
 
    - FOREIGN INVESTMENT. Each Portfolio may invest in the securities of foreign
      issuers. The risks of foreign investment include fluctuations in foreign
      currency values, political events affecting the country of issuance and
      potentially greater market volatility and lower liquidity.
 
    - EMERGING MARKET COUNTRY SECURITIES. The High Yield Portfolio may invest in
      emerging market country securities which entail risks typically associated
      with investment in more established foreign markets. However, these risks
      may be intensified due to higher volatility and less liquidity of emerging
      markets, possible political risks associated with the country of issuance
      and generally weaker financial condition of issuers in these markets.
 
                                       13
<PAGE>
    - DERIVATIVES. Each Portfolio may invest in instruments that derive their
      values from those of specified securities, indices, currencies or other
      points of reference. These derivatives, including those used to manage
      risk, are themselves subject to the risks of the different markets in
      which they are traded and, therefore, may or may not serve their intended
      purposes.
 
    For additional information about risk factors, see also "Investment
Objectives and Policies" and "Additional Investment Information."
 
                                       14
<PAGE>
                       INVESTMENT OBJECTIVES AND POLICIES
 
    The investment objective of each Portfolio is described below, together with
the policies each Portfolio employs in its efforts to achieve its objective.
Each Portfolio's investment objective is a fundamental policy which may not be
changed without the approval of a majority of the Portfolio's outstanding voting
securities. There is no assurance that a Portfolio will attain its objective. In
addition to the investments and strategies described below, the Portfolios may
invest in certain securities and obligations as set forth in "Additional
Investment Information" and as described under "Investment Objectives and
Policies" in the Statement of Additional Information. The investment policies
described below are not fundamental policies unless otherwise noted and may be
changed without shareholder approval.
 
THE SMALL CAP VALUE EQUITY PORTFOLIO
 
    The investment objective of the Small Cap Value Equity Portfolio is to
provide high long-term total return by investing in equity securities of small-
to medium-sized corporations that the Adviser believes to be undervalued
relative to the stock market in general at the time of purchase. The Portfolio
invests primarily in corporations domiciled in the United States with equity
market capitalizations in the range of the companies represented in the Russell
2500 Small Company Index, and may also invest in similar sized foreign
companies. Such range is approximately $70 million to $1.3 billion, but the
range fluctuates over time with the equity market. Under normal circumstances,
the Fund will invest at least 65% of the value of its total assets in equity
securities of issuers whose market capitalizations are within the range
represented in the Index. With respect to the Portfolio, equity securities
include common and preferred stocks, convertible securities, rights and warrants
to purchase common stocks, and similar equity interests, such as trusts or
partnership interests. These investments may or may not carry voting rights. The
Portfolio may invest in equity securities of foreign issuers that trade on a
U.S. exchange, over-the-counter or in the form of Depositary Receipts.
 
    Companies considered attractive will have the following characteristics; (i)
the market prices of the stocks will be undervalued relative to the normal
earning power of the companies; (ii) stock prices will be low relative to the
intrinsic value of the companies' assets; (iii) stocks will most often have
yields distinctly above the average of companies with similar capitalizations;
and (iv) stocks will be of high quality, in the Adviser's judgment, as evaluated
by the companies' balance sheets, income statements, franchises and product
competitiveness. The thrust of this approach is to seek investments in stocks
for which investor enthusiasm is currently low, as reflected in their valuation,
but which have the financial and fundamental features, which, in the Adviser's
opinion, will allow the stocks to achieve a higher valuation. Value is achieved
and the Portfolio reduces its holdings in a security when the investment
community's perception of the issuer improves and the price approaches what the
Adviser believes is a fair valuation.
 
THE VALUE EQUITY PORTFOLIO
 
    The investment objective of the Value Equity Portfolio is to achieve high
total return (i.e., long-term growth of capital and high current income) by
investing in equity securities that the Adviser believes to be undervalued
relative to the stock market in general at the time of purchase. The Portfolio
invests primarily in equity securities of large capitalization companies, mainly
those domiciled in the United States. With respect to the Portfolio, equity
securities include common and preferred stocks, convertible securities, and
rights and warrants to
 
                                       15
<PAGE>
purchase common stocks. Under normal circumstances, the Portfolio will invest at
least 65% of the value of its total assets in equity securities. The Portfolio
may invest up to 25% of its total assets in the equity securities of foreign
issuers, and in Depositary Receipts for such securities.
 
    The Adviser invests with the philosophy that a diversified portfolio of
undervalued equity securities will outperform the market over the long term, as
well as preserve principal in difficult market environments. Companies
considered attractive will have the following characteristics: (i) stocks most
often will have distinctly above-average dividend yields; (ii) the market prices
of the stocks will be undervalued relative to the normal earning power of the
company; (iii) many stocks will sell at close to or below the replacement value
of their assets; and (iv) most stocks' market prices will have underperformed
the general market due to a lower level of investor expectations regarding the
company outlook. The thrust of this approach is to seek investments where
current investor enthusiasm is low, as reflected in their valuations. Value is
achieved and the Portfolio reduces its holdings in a security when the
investment community's perception of the issuer improves and the price
approaches what the Adviser believes is a fair valuation.
 
THE BALANCED PORTFOLIO
 
    The investment objective of the Balanced Portfolio is to achieve high total
return while preserving capital by investing in a combination of undervalued
equity securities and fixed income securities. The Portfolio seeks strong total
return in all market conditions, with a special emphasis on minimizing interim
declines during falling equity markets. It primarily invests in large
capitalization equity securities, intermediate-maturity bonds and cash
equivalents.
 
    The Adviser uses a value-driven balanced portfolio philosophy which combines
separate equity, fixed income and asset allocation strategies. The equity
investment approach is the same as that used for the Value Equity Portfolio.
This produces a portfolio of stocks with low price-to-earnings and price-to-book
ratios and high dividend yields. The fixed income strategy values bonds using
historical yield differentials. Fixed income securities in which the Portfolio
may invest include U.S. Governmental securities, mortgage-backed securities,
corporate bonds, bank obligations and short-term money market instruments. The
asset allocation strategy shifts the stock/fixed income/cash equivalent mix
relative to calculated risk and return levels. All three strategies use
historical capital market behavior to reach conclusions.
 
    The Portfolio will typically maintain between 35% and 65% of its total
assets invested in equity securities, depending upon the Adviser's assessment of
market conditions. In overvalued equity markets, the common stock exposure will
be at the low end of this range. It is expected that equity exposure will
average approximately 55% over time. With respect to the Portfolio, equity
securities include common and preferred stocks, convertible securities, and
rights and warrants to purchase common stocks. The average maturity of the fixed
income securities held by the Portfolio will, under normal circumstances, be
approximately five years, although this will vary with changing market
conditions. Up to 25% of the Portfolio's total assets may be invested in the
securities of foreign issuers.
 
THE GLOBAL FIXED INCOME PORTFOLIO
 
    The Global Fixed Income Portfolio seeks to produce an attractive real rate
of return while preserving capital by investing in fixed income securities of
U.S. and foreign issuers denominated in U.S. dollars and in other currencies.
The Portfolio seeks to achieve its objective by investing in U.S. Government
securities, foreign government securities, securities of supranational entities,
Eurobonds, and corporate bonds with varying
 
                                       16
<PAGE>
maturities. In selecting portfolio securities, the Adviser evaluates the
currency, market, and individual features of the securities being considered for
investment. Under normal circumstances, at least 65% of the total assets of the
Portfolio will be invested in fixed income securities.
 
    The Adviser seeks to minimize investment risk by investing only in debt
securities that meet the Portfolio's quality requirements. U.S. Government
securities that the Portfolio may invest in include obligations issued by the
U.S. Government, such as U.S. Treasury securities, as well as those guaranteed
or backed by the full faith and credit of the United States, such as obligations
of the Government National Mortgage Association and The Export-Import Bank. The
Portfolio may also invest in obligations issued or guaranteed by U.S. Government
agencies or instrumentalities where the Portfolio must look principally to the
issuing or guaranteeing agency for ultimate repayment. The Portfolio may invest
in obligations issued or guaranteed by foreign governments and their political
subdivisions, authorities, agencies or instrumentalities, and by supranational
entities (such as the World Bank, The European Economic Community, The Asian
Development Bank and the European Coal and Steel Community). The Portfolio may
invest in foreign government securities of developed nations which the Adviser
believes pose limited credit risk. The Portfolio may also invest in government
securities of other countries and corporate and supranational obligations rated
A or better by Moody's Investors Services, Inc. ("Moody's"), Standard & Poor's
Ratings Group ("S&P") or IBCA Ltd. or, if unrated, those that are of comparable
quality in the determination of the Adviser.
 
    The Adviser's approach to multicurrency fixed income management is strategic
and value-based and designed to produce an attractive real rate of return. The
Adviser's assessment of bond markets and currencies is based on an analysis of
real interest rates. Current nominal yields of securities are adjusted for
inflation prevailing in each currency sector using an analysis of past and
projected inflation rates. The Portfolio's aim is to invest in bond markets
which offer the most attractive real returns.
 
    The Portfolio will have a neutral investment position in medium-term
securities (I.E., those with a remaining maturity of between three and seven
years) and will respond to changing interest rate levels by shortening or
lengthening portfolio maturity through investment in longer- or shorter-term
instruments. For example, the Portfolio will respond to high levels of real
interest rates through a lengthening in portfolio maturity. Current and
historical yield spreads among the three main market segments -- the Government,
Foreign and Euro markets -- guide the Adviser's selection of markets and
particular securities within those markets. The analysis of currencies is made
independent of the analysis of markets. Value in foreign exchange is determined
by relative purchasing power parity of a given currency. The Portfolio seeks to
invest in currencies currently undervalued based on purchasing power parity. The
Adviser analyzes current account and capital account performance and real
interest rates to adjust for shorter-term currency flows.
 
THE HIGH YIELD PORTFOLIO
 
    The High Yield Portfolio seeks to maximize total return by investing in a
diversified portfolio of high yield fixed income securities that offer a yield
above that generally available on debt securities in the four highest rating
categories of the recognized rating services. The Portfolio normally invests
between 80% and 100% of its total assets in these higher yielding securities,
which generally entails increased credit and market risk. To mitigate these
risks the Portfolio will diversify its holdings by issuer, industry and credit
quality, but investors should carefully review the section below entitled "Risk
Factors Relating to Investing in High Yield Securities."
 
                                       17
<PAGE>
    Appendix A to this Prospectus sets forth a description of the corporate bond
rating categories of Moody's and S&P. Corporate bonds rated below Baa by Moody's
or BBB by S&P are considered speculative. Securities in the lowest rating
categories may have predominantly speculative characteristics or may be in
default. Ratings of S&P and Moody's represent their opinions of the quality of
bonds and other debt securities they undertake to rate at the time of issuance.
However, ratings are not absolute standards of quality and may not reflect
changes in an issuer's creditworthiness. Accordingly, although the Adviser will
consider ratings, it will perform its own analysis of credit risk and market
risk and will not rely principally on ratings. In its selection of securities
for the Portfolio, the Adviser will consider, among other things, the price of
the security and the issuer's financial history and condition as well as the
prospects and the management of the issuer. The Portfolio may buy unrated high
yield securities consistent with the Portfolio's objective and policies. The
Adviser may vary the average maturity of the securities in the Portfolio without
limit and there is no restriction on the maturity of any individual security.
 
    The Portfolio may acquire fixed income securities of both U.S. and foreign
issuers, including debt obligations (e.g., bonds, debentures, notes, equipment
lease certificates, equipment trust certificates, conditional sales contracts,
commercial paper and obligations issued or guaranteed by the U.S. Government,
any foreign government with which the United States maintains relations or any
of their respective political subdivisions, agencies or instrumentalities) and
preferred stock. The Portfolio's fixed income securities may have equity
features such as conversion rights or warrants, and the Portfolio may invest in
equity securities other than preferred stock (e.g., common stocks, warrants and
rights and limited partnership interests). The Portfolio may not invest more
than 5% of its total assets at time of acquisition in limited partnership
interests. The Portfolio may invest in fixed income securities that are
investment grade (i.e., rated in one of the top four categories or comparable)
and have maturities of one year or less. The Portfolio may invest in or own
securities of companies in various stages of financial restructuring, bankruptcy
or reorganization which are not currently paying interest or dividends; the
total value, at time of purchase, of the sum of all such securities will not
exceed 10% of the value of the Portfolio's total assets.
 
    The table below provides a summary of ratings assigned by S&P to debt
obligations in the High Yield Portfolio. These figures are dollar-weighted
averages of month-end portfolio holdings during the fiscal year ended December
31, 1997, presented as a percentage of total investments. These percentages are
historical and are not necessarily indicative of the quality of current or
future portfolio holdings, which may vary.
 
<TABLE>
<CAPTION>
      S&P
- ----------------
         AVERAGE
         PERCENT
           OF
         PORTFOLIO
RATING   HOLDINGS
- -------  -------
<S>      <C>
AAA      9.82%
AA       0.00%
A        0.00%
BBB      1.18%
BB       39.32%
B        37.94%
CCC      6.15%
CC       0.00%
Unrated  5.59%
</TABLE>
 
                                       18
<PAGE>
    RISK FACTORS RELATING TO INVESTING IN HIGH YIELD SECURITIES.  Lower rated or
unrated (i.e., high yield) securities are more likely to react to developments
affecting market and credit risk than are more highly rated securities, which
primarily react inversely to movements in the general level of interest rates.
Yields and market values of high yield securities, however, reflect not only
changing interest rates, but the market's perception of credit quality and the
outlook for economic growth. When economic conditions appear to be
deteriorating, medium to lower rated securities may decline in value due to
heightened concern over credit quality, regardless of prevailing interest rates.
Investors should carefully consider the relative risks of investing in high
yield securities and understand that such securities are not generally meant for
short-term investing.
 
    The high yield market is still relatively new and its recent growth
parallels a long period of economic expansion and an increase in merger,
acquisition and leveraged buyout activity. Adverse economic developments may
disrupt the market for high yield securities, and severely affect the ability of
issuers, especially highly leveraged issuers, to service their debt obligations
or to repay their obligations upon maturity. In addition, the secondary market
for high yield securities, which is concentrated in relatively few market
makers, may not be as liquid as the secondary market for more highly rated
securities. As a result, the Adviser could find it more difficult to sell these
securities or may be able to sell the securities only at prices lower than if
such securities were widely traded. Under these circumstances, prices realized
upon the sale of lower rated or unrated securities may be less than the prices
used in calculating the Portfolio's net asset value. Prices for high yield
securities may be affected by legislative and regulatory developments. These
developments could adversely affect the Portfolio's net asset value and
investment practices, the secondary market for high yield securities, the
financial condition of issuers of these securities and the value of outstanding
high yield securities.
 
    Lower rated or unrated debt obligations also present risks based on payment
expectations. If an issuer calls the obligations for redemption, the Portfolio
may have to replace the security with a lower yielding security, resulting in a
decreased return for investors. If the Portfolio experiences unexpected net
redemptions, it may be forced to sell its higher rated securities, resulting in
a decline in the overall credit quality of the Portfolio's investment portfolio
and increasing the exposure of the Portfolio to the risks of high yield
securities.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    DEPOSITARY RECEIPTS.  Each Portfolio, except the Global Fixed Income and
High Yield Portfolios, is permitted to invest in Depositary Receipts, including
American Depositary Receipts ("ADRs"), Global Depositary Receipts ("GDRs"),
European Depositary Receipts ("EDRs") and other Depositary Receipts (which,
together with ADRs, GDRs and EDRs, are hereinafter collectively referred to as
"Depositary Receipts"), to the extent that such Depositary Receipts are or
become available. ADRs are securities, typically issued by a U.S. financial
institution (a "depositary"), that evidence ownership interests in a security or
a pool of securities issued by a foreign issuer (the "underlying issuer") and
deposited with the depositary. ADRs may be "sponsored" or "unsponsored."
Sponsored ADRs are established jointly by a depositary and the underlying
issuer, whereas unsponsored ADRs may be established by a depositary without
participation by the underlying issuer. The issuers of the stock of unsponsored
ADRs are not obligated to disclose material information in the United States and
therefore, there may not be a correlation between such information and the
market value of the ADR. GDRs, EDRs and other types of Depositary Receipts are
typically issued by foreign depositaries, although they may also be issued by
U.S. depositaries, and evidence ownership interests in a security or pool of
securities issued by either a foreign or a U.S. corporation. Generally,
Depositary Receipts in registered form are designed
 
                                       19
<PAGE>
for use in the U.S. securities market and Depositary Receipts in bearer form are
designed for use in securities markets outside the United States. The Portfolios
may invest in sponsored and unsponsored Depositary Receipts. For purposes of the
Portfolios' investment policies, the Portfolios' investments in Depositary
Receipts will be deemed to be investments in the underlying securities.
 
    FIXED INCOME SECURITIES.  Each Portfolio, except the Small Cap Value Equity
and Value Equity Portfolios, will invest in fixed income (debt) securities. The
market value of the fixed income securities in which a Portfolio invests will be
affected by changes in the creditworthiness of issuers and will change in
response to interest rate changes and other factors. Generally, the values of
fixed income securities vary inversely with changes in interest rates, so that
during periods of falling interest rates, the values of outstanding fixed income
securities generally rise and during periods of rising interest rates, the
values of such securities generally decline. While securities with longer
maturities tend to produce higher yields, the prices of longer maturity
securities are subject to greater market fluctuations as a result of changes in
interest rates.
 
    FOREIGN CURRENCY FORWARD CONTRACTS.  Each Portfolio may enter into foreign
currency forward contracts ("forward contracts") that provide for the purchase
or sale of an amount of a specified currency at a future date. The Portfolios
may use such contracts to protect against a decline in a foreign currency
against the U.S. dollar between the trade date and settlement date when the
Portfolio purchases or sells securities, lock in the U.S. dollar value of
dividends and interest on securities held by the Portfolio, and generally to
protect the U.S. dollar value of securities held by the Portfolio against
exchange rate fluctuation. Forward contracts may also be used as a protective
measure against the effects of fluctuating rates of currency exchange and
exchange control regulations. While forward contracts may limit losses as a
result of exchange rate fluctuations, they will also limit any gains that might
otherwise have been realized. The Portfolio's Custodian may be required to place
cash or liquid securities in a segregated account in an amount equal to the
value of the Portfolio's total assets committed to the consummation of forward
contracts. If the value of the securities placed in the segregated account
declines, additional cash or securities will be placed in the account on a daily
basis so that the value of the account will be at least equal to the amount of
the Portfolio's commitments with respect to such contracts.
 
    FOREIGN INVESTMENT.  Each Portfolio may invest in the securities of foreign
issuers. Investment in securities of foreign issuers involves investment risks
somewhat different from those affecting securities of U.S. issuers. The
Portfolio's investments will be subject to political and economic events that
affect the countries in which it invests. Foreign issuers may be subject to
different accounting, auditing and financial standards and requirements. There
also may be less government supervision and regulation of foreign securities
exchanges, brokers and listed companies than in the United States. Many foreign
securities markets have substantially less trading volume than U.S. national
securities exchanges and, therefore, securities of some foreign issuers are less
liquid and more volatile than securities of comparable U.S. issuers. Brokerage
commissions and other transaction costs on foreign securities exchanges are
generally higher than in the United States. Dividends and interest paid by
foreign issuers may be subject to withholding and other foreign taxes, which may
decrease the net return on foreign investments as compared to dividends and
interest paid to the Portfolios by domestic companies. Investments in securities
of foreign issuers are generally denominated in foreign currencies and, since a
Portfolio may temporarily hold uninvested reserves in bank deposits in foreign
currencies, the value of a Portfolio's assets as measured in U.S. dollars may be
affected favorably or unfavorably by changes in currency exchange rates and
exchange control regulations, and a Portfolio may incur costs in connection with
conversions between various currencies.
 
                                       20
<PAGE>
    The High Yield Portfolio may also invest in emerging market country
securities. Investing in emerging markets entails the risks associated with
foreign investment described above, however, these risks may be intensified in
emerging markets. Emerging markets can include every nation in the world except
the United States, Canada, Japan, Australia, New Zealand and most nations
located in Western Europe. Certain emerging market countries have historically
experienced, and may continue to experience, high rates of inflation, high
interest rates, exchange rate fluctuations, large amounts of external debt,
trade difficulties and unemployment. Further, the economies of developing
countries generally are heavily dependent upon international trade and,
accordingly, have been, and may continue to be, adversely affected by trade
barriers, exchange controls and other protectionist measures imposed or
negotiated by the countries in which they trade. There also are risks associated
with the possibility of nationalization, expropriation or confiscatory taxation,
political changes, government regulation, social instability or diplomatic
developments (including war) that could adversely affect the economies of such
countries or the value of a Portfolio's investments in those countries.
 
    LOANS OF PORTFOLIO SECURITIES.  Each Portfolio may lend its securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing net investment income. These loans must be secured
continuously by cash or equivalent collateral, or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be a risk of delay in recovery of the securities or even loss
of rights in the collateral should the borrower of the securities fail
financially. Each Portfolio will not enter into securities loan transactions
exceeding, in the aggregate, 33 1/3% of the market value of the Portfolio's
total assets. Securities lending entails certain risks of delay in recovery or
loss of rights in collateral in the event of the insolvency of the borrower.
 
    MONEY MARKET INSTRUMENTS.  Each Portfolio is permitted to invest in money
market instruments, although the Portfolios intend to stay invested in
securities satisfying their primary investment objective to the extent
practical. Consistent with their investment policies, the Portfolios may make
money market investments pending other investment or settlement for liquidity.
In addition, the Portfolios may invest in money market instruments for temporary
defensive purposes during adverse market conditions. The money market
investments permitted for the Portfolios include: obligations of the U.S.
Government and its agencies and instrumentalities, commercial paper, bank
obligations (including certificates of deposit), other debt securities and
repurchase agreements.
 
    MORTGAGE-BACKED SECURITIES.  The Balanced and High Yield Portfolios may
invest in mortgage-backed securities. Mortgage-backed securities, directly or
indirectly, represent an interest in a pool of mortgage loans on real property.
The Portfolios generally will invest in two types of mortgage-backed securities.
Mortgage pass-through securities represent a direct interest in a group of loans
that has been pooled and the loan payments passed through to security holders.
Collateralized mortgage obligations ("CMOs") are fixed income securities that,
rather than representing a direct interest in a pool of underlying mortgage
loans, are collateralized by the underlying loans. The indirect ownership
structure enables issuers to offer CMOs with a number of different classes, or
tranches, having particular risk/return characteristics.
 
    The loans may be pooled by a government agency or instrumentality, such as
the Government National Mortgage Association, which packages the loans and
guarantees repayment of principal and/or interest on the underlying loans. The
agencies or instrumentalities pooling and guaranteeing such loans may or may not
be backed by the full faith and credit of the U.S. Government. Mortgage-backed
securities also may be issued by private originators of or investors in mortgage
loans and structured similarly to governmental pass-through
 
                                       21
<PAGE>
securities. Because privately issued securities typically lack a guarantee by an
entity having the credit status of a governmental agency or instrumentality,
they often are structured with one or more types of credit enhancement.
 
    Investment in mortgage-backed securities entails certain risks. Like other
debt securities, the value of mortgage-backed securities generally varies
inversely with changes in interest rates. However, mortgage-backed securities
may respond to these changes in a manner different from other fixed income
securities because the possibility of prepayment of the underlying mortgage
loans makes it difficult to determine in advance the actual maturity date or
average life of a mortgage-backed security. Rising interest rates tend to
discourage refinancings, with the result that the average life and volatility of
the security will increase and its market price will decrease. When interest
rates fall, however, mortgage-backed securities may not gain as much in value
because increased mortgage prepayments must be reinvested at lower interest
rates.
 
    NON-PUBLICLY TRADED SECURITIES, PRIVATE PLACEMENTS AND RESTRICTED
SECURITIES.  The Portfolios may invest in securities that are neither listed on
a stock exchange nor traded over-the-counter, including privately placed
securities. Such unlisted equity securities may involve a higher degree of
business and financial risk that can result in substantial losses. As a result
of the absence of a public trading market for these securities, they may be less
liquid than publicly traded securities. Although these securities may be resold
in privately negotiated transactions, the prices realized from these sales could
be less than those originally paid by the Portfolio or less than what may be
considered the fair value of such securities. Further, companies whose
securities are not publicly traded may not be subject to the disclosure and
other investor protection requirements which might be applicable if their
securities were publicly traded. If such securities are required to be
registered under the securities laws of one or more jurisdictions before being
resold, the Portfolio may be required to bear the expenses of registration.
 
    As a general matter, a Portfolio may not invest more than 15% of its net
assets in illiquid securities, including securities for which there is no
readily available secondary market. Also, as a general matter, the Portfolio may
not invest more than 10% of its total assets in securities that are restricted
from sale to the public without registration ("Restricted Securities") under the
Securities Act of 1933, as amended (the "1933 Act"). However, the Portfolio may
invest without limit in liquid Restricted Securities that can be offered and
sold to qualified institutional buyers under Rule 144A under the 1933 Act ("Rule
144A Securities"). The Board of Directors has adopted guidelines and delegated
to the Adviser, subject to the supervision of the Board of Directors, the daily
function of determining and monitoring the liquidity of Rule 144A Securities.
Rule 144A Securities may become illiquid if qualified institutional buyers are
not interested in acquiring the securities.
 
    REPURCHASE AGREEMENTS.  Each Portfolio may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines established by
the Fund's Board of Directors. In a repurchase agreement, the Portfolio buys a
security from a seller that has agreed to repurchase it at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of the
agreement. The term of these agreements is usually from overnight to one week,
and never exceeds one year. A repurchase agreement may be viewed as a fully
collateralized loan of money by the Portfolio to the seller. Each Portfolio
always receives securities with a market value at least equal to the purchase
price (including accrued interest) as collateral, and this value is maintained
during the term of the agreement. If the seller defaults and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with respect to the seller, the Portfolio's realization upon the
collateral may be delayed or limited. The Portfolios may not enter into
repurchase agreements with more
 
                                       22
<PAGE>
than seven days to maturity if, as a result, more than 15% of the market value
of the Portfolio's net assets are invested in these agreements and other
investments for which market quotations are not readily available or which are
otherwise illiquid.
 
    TEMPORARY INVESTMENTS.  During periods in which the Adviser believes changes
in economic, financial or political conditions make it advisable, each Portfolio
may, for temporary defensive purposes, invest up to 100% of its total assets in
certain short-term and medium-term debt obligations or hold cash. The short-term
and medium-term debt obligations in which a Portfolio may invest consist of (i)
obligations of the U.S. or foreign governments, their respective agencies or
instrumentalities; (ii) money market instruments; and (iii) instruments
denominated in any currency issued by international development agencies.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  Each Portfolio may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Delivery of and payment for these securities may take
as long as a month or more after the date of the purchase commitment, but will
take place no more than 120 days after the trade date. Each Portfolio will
maintain with the Custodian a segregated account of cash or liquid securities in
an amount at least equal to these commitments. The payment obligation and the
interest rates that will be received are each fixed at the time a Portfolio
enters into the commitment and no interest accrues to the Portfolio until
settlement. Thus, it is possible that the market value at the time of settlement
could be higher or lower than the purchase price if the general level of
interest rates has changed. It is a current policy of each Portfolio not to
enter into when-issued commitments and delayed delivery commitments exceeding in
the aggregate 15% of the market value of the Portfolio's total assets less
liabilities other than the obligations created by these commitments.
 
    ZERO COUPON, PAY-IN-KIND AND DEFERRED PAYMENT SECURITIES.  The High Yield
Portfolio may invest in zero coupon, pay-in-kind or deferred payment securities.
Zero coupon securities are securities that are sold at a discount to par value
and securities on which interest payments are not made during the life of the
security. Upon maturity, the holder is entitled to receive the par value of the
security. While interest payments are not made on such securities, holders of
such securities are deemed to have received "phantom income" annually. Because
the Portfolio will distribute its "phantom income" to shareholders, to the
extent that shareholders elect to receive dividends in cash rather than
reinvesting such dividends in additional shares of the Portfolio, it will have
fewer assets with which to purchase income producing securities. The Portfolio
accrues income with respect to these securities prior to the receipt of cash
payments. Pay-in-kind securities are securities that have interest payable by
delivery of additional securities. Upon maturity, the holder is entitled to
receive the aggregate par value of the securities. Deferred payment securities
are securities that remain zero coupon securities until a predetermined date, at
which time the stated coupon rate becomes effective and interest becomes payable
at regular intervals. Zero coupon, pay-in-kind and deferred payment securities
may be subject to greater fluctuation in value and lesser liquidity in the event
of adverse market conditions than comparably rated securities paying cash
interest at regular interest payment periods.
 
DERIVATIVE PRODUCTS (DERIVATIVES)
 
    The Portfolios are permitted to utilize various exchange-traded and
over-the-counter derivative instruments and derivative securities, both for
hedging and non-hedging purposes. Permitted derivative products include, but are
not limited to: futures contracts ("futures"); forward contracts ("forwards");
options; swaps, caps,
 
                                       23
<PAGE>
collars and floors; structured notes; and other derivative products yet to be
developed, so long as these new products are used in a manner consistent with
the objectives of the Portfolios. These derivative products may be based upon a
wide variety of underlying rates, indices, instruments, securities and other
products, such as interest rates, foreign currencies, foreign and domestic fixed
income and equity securities, groups or "baskets" of securities and securities
indices (for each derivative product, the "underlying"). Exclusive of forward
foreign currency contracts and any derivative products used for hedging
purposes, each Portfolio will limit its use of derivative products to 33 1/3% of
its total assets, measured by the aggregate notional amount of outstanding
derivative products.
 
    The Portfolios may use derivative products under a number of different
circumstances to further their investment objectives. For example, a Portfolio
may purchase derivatives to gain exposure to a market quickly in response to
changes in the Portfolio's investment strategy, upon the inflow of investable
cash or when the derivative provides greater liquidity than the underlying
market. A Portfolio may also use derivatives when it is restricted from directly
owning the "underlying" or when derivatives provide a pricing advantage or lower
transaction costs. The Portfolios also may purchase combinations of derivatives
in order to gain exposure to an investment in lieu of actually purchasing such
investment. Derivatives may also be used by a Portfolio for hedging or risk
management purposes and in other circumstances when the Adviser believes it
advantageous to do so consistent with the Portfolio's investment objectives and
policies. The Portfolios will not use derivatives in a manner that creates
leverage, except to the extent that the use of leverage is expressly permitted
by a particular Portfolio's investment policies, and then only in a manner
consistent with such policies.
 
    The use of derivative products is a highly specialized activity which
involves investment techniques and risks different from those associated with
ordinary portfolio securities transactions. If the Adviser is incorrect in
forecasts of market values, interest rates, and currency exchange rates, the
investment performance of the Portfolios will be less favorable than it would
have been if these investment techniques had not been used.
 
    Some of the derivative products in which the Portfolios may invest and some
of the risks related thereto are described in more detail below.
 
FUTURES CONTRACTS (FUTURES) AND FORWARD CONTRACTS (FORWARDS)
 
    The Portfolios may purchase and sell futures contracts of the type generally
known as financial futures, such as futures on securities indices, baskets of
securities, foreign currencies and interest rates. These are standardized
contracts that are bought and sold on organized exchanges. A futures contract
obligates a party to buy or sell a specific amount of the "underlying," such as
for example, a particular foreign currency, on a specified future date at a
specified price or to settle the value in cash.
 
    The Portfolios may also purchase and sell forward contracts, such as forward
rate agreements and other financial forward contracts. The Portfolios may also
use foreign currency forward contracts which are separately discussed elsewhere
in this Prospectus. See "Foreign Currency Forward Contracts" above. These
forward contracts are privately negotiated and are bought and sold in the
over-the-counter market. Like a future, a forward contract obligates a party to
buy or sell a specific amount of the underlying on a specified future date at a
specified price. The terms of the forward contract are customized. Forward
contracts, like other over-the-counter contracts that are negotiated directly
with an individual counterparty, subject the Portfolio to the risk of
counterparty default.
 
                                       24
<PAGE>
    In some cases, the Portfolios may be able to use either futures contracts,
forward contracts or exchange-traded or over-the-counter options to accomplish
similar purposes. In all cases, the Portfolios will use these products only as
permitted by applicable laws and regulations. Some of the ways in which the
Portfolios may utilize futures contracts, forward contracts and related options
are as follows:
 
    The Portfolios may sell securities index futures contracts and/or index
options thereon in anticipation of or during a market decline to attempt to
offset the decrease in market value of investments in its portfolio, or may
purchase securities index futures or options in order to gain market exposure.
There currently are limited securities index futures and options on such futures
in many countries, particularly emerging countries. The nature of the strategies
adopted by the Adviser, and the extent to which those strategies are used, may
depend on the development of such markets. The Portfolios may also purchase and
sell foreign currency futures to hedge their respective holdings and commitments
against changes in the level of future currency rates or to adjust their
exposure to a particular currency.
 
    The Portfolios may engage in transactions in interest rate futures and
related products. The value of these contracts rises and falls inversely with
changes in interest rates. The Portfolios may engage in such transactions to
hedge their holdings of debt instruments against future changes in interest
rates or for other purposes.
 
    The Portfolios may also purchase or sell futures and forwards on other
financial instruments, such as U.S. Government securities and certificates of
deposit. The value of these contracts also rises and falls inversely with
changes in interest rates. The Portfolios may engage in financial futures and
forward contracts for both hedging and non-hedging purposes.
 
    Gains and losses on futures contracts, forward contracts and related options
depend on the Adviser's ability to predict correctly the direction of securities
prices, interest rates and other economic factors. Other risks associated with
the use of these instruments include (i) imperfect correlation between the
change in market value of investments held by a Portfolio and the prices of
derivative products relating to investments purchased or sold by the Portfolio,
and (ii) possible lack of a liquid secondary market for a derivative product and
the resulting inability to close out a position. The risk that a Portfolio will
be unable to close out a position will be minimized by only entering into
transactions for which there appears to be a liquid exchange or secondary
market. In some strategies, the risk of loss in trading on futures and related
transactions can be substantial, due both to the low margin deposits required
and the extremely high degree of leverage involved in pricing.
 
    Under rules adopted by the Commodity Futures Trading Commission (the
"CFTC"), each Portfolio may, without registering with the CFTC as a Commodity
Pool Operator, enter into futures contracts and options thereon for both hedging
and non-hedging purposes, provided that not more than 5% of such Portfolio's
total assets at the time of entering the transaction are required as margin and
option premiums to secure obligations under such contracts relating to non-bona
fide hedging activities.
 
OPTION TRANSACTIONS
 
    The Portfolios may seek to increase their returns or may hedge their
portfolio investments through options transactions with respect to individual
securities, indices or baskets in which such Portfolios may invest; other
financial instruments; and foreign currency. Various options may be purchased
and sold on either the exchange-traded or over-the-counter markets.
 
                                       25
<PAGE>
    Each Portfolio may purchase put and call options. Purchasing a put option
gives a Portfolio the right, but not the obligation, to sell the underlying
(such as a securities index or a particular foreign currency) at the exercise
price either on a specific date or during a specified exercise period.
Purchasing a call option gives a Portfolio a similar right, but not the
obligation, to purchase the underlying. The purchaser pays a premium to the
seller (also known as the writer) of the option.
 
    Each Portfolio also may write put and call options on investments held in
its portfolio, as well as foreign currency options. A Portfolio that has written
an option receives a premium that increases the Portfolio's return on the
underlying in the event the option expires unexercised or is closed out at a
profit. However, by writing a call option, a Portfolio will limit its
opportunity to profit from an increase in the market value of the underlying
above the exercise price of the option. By writing a put option, a Portfolio
will be exposed to the amount by which the price of the underlying is less than
the strike price.
 
    By writing an option, a Portfolio incurs an obligation either to buy (in the
case of a put option) or sell (in the case of a call option) the underlying from
the purchaser of the option at the option's exercise price, upon exercise by the
purchaser. Pursuant to guidelines established by the Board of Directors, the
Portfolios may only write options that are "covered." A covered call option
means that until the expiration of the option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will continue to own (i) the underlying; (ii) securities or instruments
convertible or exchangeable without the payment of any consideration into the
underlying; or (iii) a call option on the same underlying with a strike price no
higher than the price at which the underlying was sold pursuant to a short
option position. In the case of a put option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will own another put option on the same underlying with an equal or higher
strike price.
 
    There currently are limited options markets in many countries, particularly
emerging market countries, and the nature of the strategies adopted by the
Adviser and the extent to which those strategies are used will depend on the
development of these options markets. The primary risks associated with the
Portfolios' use of options as described include (i) imperfect correlation
between the change in market value of investments held, purchased or sold by a
Portfolio and the prices of options relating to such investments, and (ii)
possible lack of a liquid secondary market for an option.
 
INTEREST RATE, CURRENCY, COMMODITY AND EQUITY SWAPS, CAPS, COLLARS AND FLOORS
 
    Swaps are privately negotiated over-the-counter derivative products in which
two parties agree to exchange payment streams calculated in relation to a rate,
index, instrument or certain securities and a particular "notional amount." As
with many of the other derivative products available to the Portfolios, the
underlying may include an interest rate (fixed or floating), a currency exchange
rate, a commodity price index, and a security, securities index or a combination
thereof. A great deal of flexibility is possible in the way the products may be
structured, with the effect being that the parties may have exchanged amounts
equal to the return on one rate, index or group of securities for another. For
example, in a simple fixed-to-floating interest rate swap, one party makes
payments equivalent to a fixed interest rate, and the other makes payments
equivalent to a specified interest rate index. A Portfolio may engage in simple
or more complex swap transactions involving a wide variety of underlyings. The
currency swaps that the Portfolios may enter will generally involve an agreement
to pay
 
                                       26
<PAGE>
interest streams in one currency based on a specified index in exchange for
receiving interest streams denominated in another currency. Such swaps may
involve initial and final exchanges that correspond to the agreed upon notional
amount.
 
    Caps, collars and floors are privately-negotiated option-based derivative
products. A Portfolio may use one or more of these products in addition to or in
lieu of a swap involving a similar rate or index. As in the case of a put or
call option, the buyer of a cap or floor pays a premium to the writer. In
exchange for that premium, the buyer receives the right to a payment equal to
the differential if the specified index or rate rises above (in the case of a
cap) or falls below (in the case of a floor) a pre-determined strike level. As
in the case of swaps, obligations under caps and floors are calculated based
upon an agreed notional amount, and like most swaps (other than foreign currency
swaps), the entire notional amount is not exchanged and thus is not at risk. A
collar is a combination product in which the same party, such as the Portfolio,
buys a cap from and sells a floor to the other party. As with put and call
options, the amount at risk is limited for the buyer, but, if the cap or floor
is not hedged or covered, may be unlimited for the seller. Under current market
practice, caps, collars and floors between the same two parties are generally
documented under the same "master agreement." In some cases, options and forward
agreements may also be governed by the same master agreement. In the event of a
default, amounts owed under all transactions entered into under, or covered by,
the same master agreement would be netted and only a single payment would be
made.
 
    Swaps, caps, collars and floors are credit-intensive products. A Portfolio
that enters into a swap transaction bears the risk of default, i.e. nonpayment,
by the other party. The guidelines under which each Portfolio enters derivative
transactions, along with some features of the transactions themselves, are
intended to reduce these risks to the extent reasonably practicable, although
they cannot eliminate the risks entirely. Under guidelines established by the
Board of Directors, a Portfolio may enter into swaps only with parties that meet
certain credit rating guidelines. Consistent with current market practices, a
Portfolio will generally enter into swap transactions on a net basis, and all
swap transactions with the same party will be documented under a single master
agreement to provide for net payment upon default. In addition, a Portfolio's
obligations under an agreement will be accrued daily (offset against any amounts
owing to the Portfolio) and any accrued, but unpaid, net amounts owed to the
other party to a master agreement will be covered by the maintenance of a
segregated account consisting of cash or liquid securities.
 
    Interest rate and total rate of return (fixed income or equity) swaps
generally do not involve the delivery of securities, other underlying assets, or
principal. In such case, if the other party to an interest rate or total rate of
return swap defaults, a Portfolio's risk of loss will consist of the payments
that a Portfolio is contractually entitled to receive from the other party. This
may not be true for currency swaps that require the delivery of the entire
notional amount of one designated currency in exchange for the other. If there
is a default by the other party, a Portfolio may have contractual remedies
pursuant to the agreements related to the transaction.
 
STRUCTURED NOTES
 
    Structured notes are derivative securities for which the amount of principal
repayment and/or interest payments is based upon the movement of one or more
factors. These factors include, but are not limited to, currency exchange rates,
interest rates (such as the prime lending rate and LIBOR) and stock indices,
such as the S&P 500. In some cases, the impact of the movements of these factors
may increase or decrease through the use of multipliers or deflators. The
Portfolios may use structured notes to tailor their investments to the specific
risks and returns the Adviser wishes to accept while avoiding or reducing
certain other risks.
 
                                       27
<PAGE>
                             INVESTMENT LIMITATIONS
 
    As a diversified investment company, each Portfolio, except the Global Fixed
Income Portfolio, is subject to the following limitations: (i) as to 75% of its
total assets, a Portfolio may not invest more than 5% of its total assets in the
securities of any one issuer, except obligations of the U.S. Government and its
agencies and instrumentalities, and (ii) a Portfolio may not own more than 10%
of the outstanding voting securities of any one issuer.
 
    The Global Fixed Income Portfolio is a non-diversified investment company
under the Investment Company Act of 1940, as amended (the "1940 Act"), which
means the Global Fixed Income Portfolio is not limited by the 1940 Act in the
proportion of its total assets that may be invested in the obligations of a
single issuer. Thus, the Global Fixed Income Portfolio may invest a greater
proportion of its total assets in the securities of a smaller number of issuers
and, as a result, will be subject to greater risk with respect to its portfolio
securities. Nevertheless, the Global Fixed Income Portfolio intends to comply
with the more limited diversification requirements imposed by the Internal
Revenue Code of 1986, as amended (the "Code"), for qualification as a regulated
investment company.
 
    Each Portfolio also operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of the
holders of a majority of such Portfolio's outstanding shares and under certain
non-fundamental investment limitations that may be changed without shareholder
approval. For additional information on fundamental and non-fundamental
investment limitations, see "Investment Limitations" in the Statement of
Additional Information.
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and each Portfolio. The Adviser provides investment
advice and portfolio management services pursuant to an Investment Advisory
Agreement and, subject to the supervision of the Fund's Board of Directors,
makes each Portfolio's day-to-day investment decisions, arranges for the
execution of portfolio transactions and generally manages each Portfolio's
investments. Set forth below as an annual percentage of average daily net assets
are the management fees payable to the Adviser quarterly by each Portfolio
pursuant to the terms of the Investment Advisory Agreement. The Adviser has
voluntarily agreed to a reduction in the fees payable to it and to reimburse the
Portfolios, if necessary, if such fees would cause total annual operating
expenses of the Portfolios to exceed the maximums set forth in the table below.
 
<TABLE>
<CAPTION>
                                                      MAXIMUM TOTAL OPERATING
                                                              EXPENSES
                                                         AFTER FEE WAIVERS
                                       MANAGEMENT   ----------------------------
PORTFOLIO                                 FEE          CLASS A        CLASS B
- ------------------------------------  ------------  -------------  -------------
<S>                                   <C>           <C>            <C>
Small Cap Value Equity Portfolio         0.85%            1.00%          1.25%
Value Equity Portfolio                   0.50%            0.70%          0.95%
Balanced Portfolio                       0.50%            0.70%          0.95%
Global Fixed Income                      0.40%            0.50%          0.65%
High Yield                               0.375%           0.75%          1.00%
</TABLE>
 
                                       28
<PAGE>
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to customers in the
United States and abroad. Morgan Stanley Dean Witter & Co. ("MSDW") is the
direct parent of the Adviser and Morgan Stanley. MSDW is a preeminent global
financial services firm that maintains leading market positions in each of its
three primary businesses -- securities, asset management and credit services. At
March 31, 1998, the Adviser, together with its affiliated institutional asset
management companies managed assets of approximately $166 billion, including
assets under fiduciary advice. See "Management of the Fund" in the Statement of
Additional Information.
 
    PORTFOLIO MANAGERS. The following individuals have primary portfolio
management responsibility for the Portfolios noted below:
 
    SMALL CAP VALUE EQUITY PORTFOLIO -- WILLIAM B. GERLACH AND GARY G.
SCHLARBAUM.  William B. Gerlach joined the Adviser in July 1996 and has worked
with the Adviser's affiliate, Miller Anderson & Sherrerd, LLP ("MAS") since
1991. Previously, he was with Alphametrics Corporation and Wharton Econometric
Forecasting Associates. Mr. Gerlach received a B.A. in Economics from Haverford
College. Gary G. Schlarbaum, a Managing Director of Morgan Stanley, joined MAS
in 1987. He assumed responsibility for the MAS Funds Equity and Small Cap Value
Portfolios in 1987, the MAS Funds Balanced Portfolio in 1992 and the MAS Funds
Multi-Asset-Class and Mid Cap Value Portfolios in 1994. Mr. Schlarbaum also is a
Director of MAS Fund Distribution, Inc. Previously, he was with First Chicago
Investment Advisers and was a Professor at the Krannert Graduate School at
Purdue University. Mr. Schlarbaum holds a B.A. in Economics from Coe College and
a Ph.D. in Applied Economics from University of Pennsylvania. Mr. Gerlach and
Mr. Schlarbaum have had primary responsibility for managing the Small Cap Value
Equity Portfolio since June 1997.
 
    VALUE EQUITY AND BALANCED PORTFOLIOS -- STEPHEN C. SEXAUER AND PHILIP W.
FRIEDMAN.   Stephen C. Sexauer is a Principal of Morgan Stanley and the Adviser
and is a member of the investment management team of the Adviser. In addition to
portfolio management, his equity research responsibilities include financials,
energy, utilities and technology. Mr. Sexauer joined the firm in July 1989 after
three years as a Vice President at Salomon Brothers. Previously, he was with
Merrill Lynch Economics and Wharton Econometrics. Mr. Sexauer received a B.S. in
Economics from the University of Illinois and an M.B.A. in Economics and
Statistics from the University of Chicago. Philip W. Friedman is a Managing
Director of Morgan Stanley and the Adviser and is a member of the investment
management team of the Adviser. In addition to portfolio management, his equity
research responsibilities include business equipment and services, capital
goods, consumer durables, multi-industry and transportation. Prior to joining
the Adviser in 1997, he was the North American Director of Equity Research at
Morgan Stanley. From 1990 to 1995, he was a member of Morgan Stanley's Equity
Research team. Mr. Friedman graduated from Rutgers University with a B.A. (PHI
BETA KAPPA AND SUMMA CUM LAUDE) in Economics. He also holds an M.B.A. from J.L.
Kellogg School of Management at Northwestern University. Mr. Sexauer and Mr.
Friedman have had primary responsibility for managing the Value Equity Portfolio
since January 1992 and July 1997, respectively. Mr. Sexauer and Mr. Friedman
have had primary responsibility for managing the Balanced Portfolio since
February 1990 and July 1997, respectively.
 
                                       29
<PAGE>
    GLOBAL FIXED INCOME PORTFOLIO -- J. DAVID GERMANY, MICHAEL B. KUSHMA, PAUL
F. O'BRIEN, ROBERT M. SMITH AND RICHARD B. WORLEY. J. David Germany joined the
Adviser in 1996 and has been a portfolio manager with MAS since 1991. He was
Vice President & Senior Economist for Morgan Stanley from 1989 to 1991. He
assumed responsibility for the Global Fixed Income and International Fixed
Income Portfolios of the MAS-advised MAS Funds in 1993 and the MAS Funds
Multi-Asset-Class Portfolio in 1994. Mr. Germany was Senior Staff Economist
(International Finance and Macroeconomics) to the Council of Economic Advisers
- -- Executive Office of the President from 1986 through 1987 and an Economist
with the Board of Governors of the Federal Reserve System -- Division of
International Finance from 1983 through 1987. He holds an A.B. degree
(Valedictorian) from Princeton University and a Ph.D. in Economics from the
Massachusetts Institute of Technology. Michael B. Kushma, a Principal at Morgan
Stanley, joined the firm in 1987. He was a member of Morgan Stanley's global
fixed income strategy group in the fixed income division from 1987 to 1995,
where he became the division's senior government bond strategist. He joined the
Adviser in 1995, where he took responsibility for global fixed income bond
strategy. Mr. Kushma received an A.B. in economics from Princeton University in
1979, and an M.Sc. in economics from Columbia University in 1983. Paul F.
O'Brien joined the Adviser and MAS in 1996. He was head of European Economics
from 1993 through 1995 for JP Morgan and a Principal Administrator from 1991
through 1992 for the Organization for Economic Cooperation and Development. He
assumed responsibility for the MAS-advised MAS Funds Global Fixed Income and
International Fixed Income Portfolios in 1996. Mr. O'Brien holds a B.S. degree
from the Massachusetts Institute of Technology and a Ph.D. in Economics from the
University of Minnesota. Robert M. Smith, a Principal of Morgan Stanley, joined
the Adviser in June 1994. Prior to joining the Adviser, he spent eight years as
Senior Portfolio Manager -- Fixed Income at the State of Florida Pension Fund.
Mr. Smith's responsibilities included active total rate of return management of
long-term portfolios and supervision of other fixed income managers. A graduate
of Florida State University with a B.S. in Business, Mr. Smith also received an
M.B.A. -- Finance from Florida State and holds a Chartered Financial Analyst
(CFA) designation. Richard B. Worley, a Managing Director of Morgan Stanley,
joined MAS in 1978. He assumed responsibility for the MAS Funds Fixed Income
Portfolio in 1984, the MAS Funds Domestic Fixed Income Portfolio in 1987, the
MAS Funds Fixed Income Portfolio II in 1990, the MAS Funds Balanced and Special
Purpose Fixed Income Portfolios in 1992, the MAS Funds Global Fixed Income and
International Fixed Income Portfolios in 1993 and the MAS Funds
Multi-Asset-Class Portfolio in 1994. Mr. Worley received a B.A. in Economics
from University of Tennessee and attended the Graduate School of Economics at
University of Texas. J. David Germany, Michael B. Kushma, Paul F. O'Brien,
Robert M. Smith and Richard B. Worley have had primary responsibility for
managing the Global Fixed Income Portfolio since September 1997.
 
    HIGH YIELD PORTFOLIO -- ROBERT ANGEVINE, THOMAS L. BENNETT AND STEPHEN F.
ESSER. Robert Angevine is a Principal of the Adviser and the Portfolio Manager
for high yield investments. Prior to joining the Adviser in October 1988, he
spent over eight years at Prudential Insurance where he was responsible for one
of the largest open-end high yield mutual fund in the country. Mr. Angevine also
manages high yield assets for one of the largest corporate pension funds in the
country. His other experience includes international treasury operations at a
major pharmaceutical company and commercial banking. Mr. Angevine received an
M.B.A from Fairleigh Dickinson University and a B.A. in Economics from Lafayette
College. He served two years as a Lieutenant in the U.S. Army. Mr. Angevine has
had primary responsibility for managing the Portfolio's assets since its
inception. Thomas L. Bennett joined the Adviser in 1996 and has been a portfolio
manager with MAS since 1984. Mr. Bennett assumed responsibility for the
MAS-advised MAS Funds' Fixed Income Portfolio in 1984, the
 
                                       30
<PAGE>
Domestic Fixed Income Portfolio in 1987, the High Yield Portfolio in 1985, the
Fixed Income Portfolio II in 1990, the Special Purpose Fixed Income and Balanced
Portfolios in 1992 and the Multi-Asset-Class Portfolio in 1994. Mr. Bennett also
is the Chairman of the MAS Funds and has a B.S degree (Chemistry) and an M.B.A.
from the University of Cincinnati. Stephen F. Esser joined the Adviser in 1996
and has been a portfolio manager with MAS since 1988. He assumed responsibility
for the MAS-advised MAS Funds' High Yield Portfolio in 1989. Mr. Esser is a
member of the New York Society of Security Analysts and has a B.S. degree (SUMMA
CUM LAUDE; PHI BETA KAPPA) from the University of Delaware. Mr. Bennett and Mr.
Esser have had primary responsibility for managing the Portfolio's assets since
April 1996.
 
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the officers and the
Board of Directors of the Fund and include day-to-day administration of matters
related to the corporate existence of the Fund, maintenance of its records,
preparation of reports, supervision of the Fund's arrangements with its
custodian, and assistance in the preparation of the Fund's registration
statements under federal laws. The Administration Agreement also provides that
the Administrator, through its agents, will provide dividend disbursing and
transfer agent services to the Fund. For its services under the Administration
Agreement, the Fund pays the Adviser a monthly fee which on an annual basis
equals 0.15% of the average daily net assets of each Portfolio.
 
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors such administrative services provided by CGFSC.
Their services are also subject to the supervision of the Board of Directors of
the Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of each Portfolio upon the terms and at the current
offering price described in this Prospectus. Morgan Stanley is not obligated to
sell any certain number of shares of any Portfolio.
 
    The Portfolios currently offer only the classes of shares offered by this
Prospectus. The Portfolios may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares of each Portfolio pursuant to Rule 12b-1 under the 1940 Act (each, a
"Plan"). Under each Plan, the Distributor is entitled to receive compensation
from each Portfolio, which is accrued daily and paid quarterly, equal to 0.25%
of the Class B shares' average daily net assets on an annualized basis. Each
Plan is designed to compensate the Distributor for its services in connection
with distribution assistance. The Distributor may retain any portion of the fee
that it does not expend in meeting its obligations to the Fund. The Distributor
may compensate financial intermediaries, plan fiduciaries and adminsitrators for
providing distribution-related services, including account
 
                                       31
<PAGE>
maintenance services, to shareholders (including, where applicable, underlying
beneficial owners) of Class B shares. The Distributor has agreed to waive 0.10%
of the 0.25% distribution fee it is entitled to receive from the Global Fixed
Income Portfolio.
 
    EXPENSES.  Each Portfolio is responsible for payment of certain other fees
and expenses (including legal fees, accountant's fees, custodial fees and
printing and mailing costs) as specified in its agreements with the Adviser and
Morgan Stanley.
 
    YEAR 2000.  The management and distribution services provided to the Fund by
the Adviser and Morgan Stanley depend on the smooth functioning of their
computer systems. Many computer software systems in use today cannot recognize
the year 2000, but revert to 1900 or some other date, due to the manner in which
dates were encoded and calculated. That failure could have a negative impact on
the handling of securities trades, pricing and account services. The Adviser and
Morgan Stanley have been actively working on necessary changes to their own
computer systems to deal with the year 2000 problem and expect that their
systems will be adapted before that date. There can be no assurance, however,
that they will be successful. In addition, other unaffiliated service providers
may be faced with similar problems. The Adviser and Morgan Stanley are
monitoring their remedial efforts, however, there can be no assurance that they
and the services they provide will not be adversely affected.
 
    In addition, it is possible that the markets for securities in which the
Portfolios invest may be detrimentally affected by computer failures throughout
the financial services industry beginning January 1, 2000. Improperly
functioning trading systems may result in settlement problems and liquidity
issues. In addition, corporate and governmental data processing errors may
result in production problems for individual companies and overall economic
uncertainties. Earnings of individual issuers will be affected by remediation
costs, which may be substantial and may be reported inconsistently in U.S. and
foreign financial statements. Accordingly, the Portfolios' investments may be
adversely affected.
 
                               PURCHASE OF SHARES
 
    Class A shares of each Portfolio and Class B shares of each Portfolio may be
purchased at the net asset value per share next determined after receipt by the
Fund of a purchase order as described under "Methods of Purchase." The net asset
value per share of each Portfolio is calculated on days that the New York Stock
Exchange ("NYSE") and Chase (the "Custodian") are open for business as of the
close of trading of the NYSE, normally 4:00 p.m. Eastern Time (the "Pricing
Time").
 
MINIMUM INVESTMENT
 
    The minimum initial investment is $500,000 for Class A shares and $100,000
for Class B shares of each Portfolio. These minimums may be waived at the
discretion of the Adviser for certain types of investors, including trust
departments, brokers, dealers, agents, financial planners, financial services
firms, investment advisers or various retirement and deferred compensation plans
("Financial Intermediaries"), certain accounts managed by the Adviser and its
affiliates ("Managed Accounts"), and certain employees and customers of Morgan
Stanley and its affiliates. The Fund's determination of an investor's
eligibility to purchase shares of a given class will take precedence over the
investor's selection of a class.
 
                                       32
<PAGE>
METHODS OF PURCHASE
 
    Shares may be purchased directly from the Fund by Federal Funds wire, by
bank wire or by check. Investors may also invest in the Portfolios by purchasing
shares through Financial Intermediaries that have made arrangements with Morgan
Stanley. Some Financial Intermediaries may charge an additional service or
transaction fee. If a purchase is canceled due to nonpayment or because your
check does not clear, you will be responsible for any loss the Fund or its
agents incur. If you are already a shareholder, the Fund may redeem shares from
your account(s) to reimburse the Fund or its agents for any loss. In addition,
you may be prohibited or restricted from making future investments in the Fund.
 
    FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire Federal
Funds to the Fund's bank account. Federal Funds purchase orders will be accepted
only on a day on which the Fund and the Custodian are open for business. Your
bank may charge a service fee for wiring Federal Funds. In order to ensure
proper handling of your purchase by Federal Funds wire, please follow these
steps:
 
    1.  Place your order by telephoning the Fund at 1-800-548-7786. A Fund
       representative will request certain purchase information and provide you
       with a confirmation number.
 
    2.  Instruct your bank to wire the specified amount to the Fund's Wire
       Concentration Bank Account as follows:
 
       The Chase Manhattan Bank
       One Manhattan Plaza
       New York, NY 10081-1000
       ABA# 021000021
       DDA# 910-2-733293
       Attn: Morgan Stanley Institutional Fund, Inc.
       Ref: (Portfolio name, your account number, your account name)
 
        Please call the Fund at 1-800-548-7786 prior to wiring the funds.
 
    3.  Complete and sign the Account Registration Form and mail it to the
       address shown thereon.
 
    When a purchase order is received prior to the Pricing Time and Federal
Funds are received prior to the close of the Federal Funds Wire Control Center
("FFWCC") (normally 6:00 p.m. Eastern Time), the purchase will be executed at
the net asset value computed on the date of receipt. Purchases for which an
order is received after the Pricing Time or for which Federal Funds are received
after the close of the FFWCC, will be executed at the net asset value next
determined. Certain institutional investors and financial institutions have
entered into an arrangement with Morgan Stanley, pursuant to which they may
place orders prior to the Pricing Time, but make payment in Federal Funds for
those shares on the following business day.
 
    BANK WIRE.  A purchase of shares by bank wire must follow the same procedure
as for a Federal Funds wire, described above. However, depending on the time the
bank wire is sent and which bank is handling the wire, money transferred by bank
wire may or may not be converted into Federal Funds prior to the close of the
FFWCC. Prior to conversion to Federal Funds and receipt by the Fund, an
investor's money will not be invested.
 
                                       33
<PAGE>
    CHECK.  An account may be opened by completing and signing an Account
Registration Form and mailing it, together with a check payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio name]" to:
 
    Morgan Stanley Institutional Fund, Inc.
    P.O. Box 2798
    Boston, Massachusetts 02208-2798
 
    The Fund ordinarily is credited with Federal Funds within one business day
of deposit of a check. Thus, a purchase of shares by check ordinarily will be
credited to your account at the net asset value per share of each of the
Portfolios determined on the next business day after receipt. An investor's
money will not be invested prior to crediting of Federal Funds.
 
    INVESTMENT THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to receive purchase and
redemption orders from underlying beneficial owners, such as retirement plan
participants, generally on each business day. After the Pricing Time, the
Financial Intermediary aggregates all orders received from underlying beneficial
owners prior to the Pricing Time on that business day and places a net purchase
and/or redemption order(s) by the morning of the next business day. These orders
normally are executed at the net asset value that was computed for each
Portfolio as of the close of the previous business day.
 
    ADDITIONAL INVESTMENTS.  You may purchase additional shares for your account
at any time by purchasing shares at net asset value by any of the methods
described above. The minimum additional investment generally is $1,000 per
Portfolio. The minimum additional investment may be lower for certain accounts,
described above under "Minimum Investment." For purchases directly from the
Fund, your account name, the Portfolio name and the class selected must be
specified in the letter or wire to assure proper crediting to your account.
 
INVOLUNTARY CONVERSION AND REDEMPTION OF NEW ACCOUNT SHARES
 
    Class A and Class B shares of each Portfolio may be subject to the
involuntary conversion and redemption features described below. The conversion
and redemption features may be waived at the discretion of the Adviser for
shares held in a Managed Account and shares purchased through a Financial
Intermediary. Accounts that were open prior to January 2, 1996 are not subject
to involuntary conversion or redemption. The Fund reserves the right to modify
or terminate the conversion or redemption features of the shares at any time
upon 60 days notice to shareholders.
 
    CONVERSION FROM CLASS A TO CLASS B SHARES.  If the value of an account
containing Class A shares falls below $500,000 (but remains at or above
$100,000) because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $500,000 (but remains at or
above $100,000) for a continuous 60-day period, the Class A shares in such
account will convert to Class B shares and will be subject to the distribution
fee and other features applicable to Class B shares. The Fund will not convert
Class A shares to Class B shares based solely upon changes in the market that
reduce the net asset value of shares. Under current tax law, conversion between
share classes is not a taxable event to the shareholder.
 
    CONVERSION FROM CLASS B TO CLASS A SHARES.  If the value of an account
containing Class B shares increases to $500,000 or more, whether due to
shareholder purchases or market activity, the Class B shares will convert to
Class A shares. Under current tax law, such conversion is not a taxable event to
the shareholder. Class B shares purchased through a Financial Intermediary that
has entered into an arrangement with the Fund
 
                                       34
<PAGE>
for the purchase of such shares may not be converted. Class A shares converted
from Class B shares are subject to the same minimum account size requirements as
are applicable to New Accounts containing Class A shares described above.
 
    INVOLUNTARY REDEMPTION OF SHARES.  If the value of an account falls below
$100,000 because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $100,000 for a continuous
60-day period, the shares in such account will be subject to redemption by the
Fund. The Fund will not redeem shares based solely upon changes in the market
that reduce the net asset value of shares. If redeemed, redemption proceeds will
be promptly paid to the shareholder.
 
                              REDEMPTION OF SHARES
 
    Class A and Class B shares of each Portfolio may be redeemed at any time and
without charge at the net asset value per share next determined after receipt by
the Fund of a redemption order as described under "Methods of Redemption."
Redemption proceeds may be more or less than the purchase price of your shares
depending on, among other factors, the market value of the investment securities
held by a Portfolio.
 
METHODS OF REDEMPTION
 
    Shares may be redeemed directly from the Fund by mail or by telephone.
However, shares purchased through a Financial Intermediary must be redeemed
through a Financial Intermediary. Certain Financial Intermediaries may charge an
additional service or transaction fee.
 
    BY MAIL.  Each Portfolio will redeem shares upon receipt of a redemption
request in "good order." Redemption requests may be sent by regular mail to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798 or, by overnight courier, to Morgan Stanley Institutional Fund, Inc.,
c/o Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913.
 
    "Good order" means that the request to redeem shares must include the
following:
 
    1.  A letter of instruction or a stock assignment specifying the class and
number of shares or dollar amount to be redeemed, signed by all registered
owners of the shares in the exact names in which they are registered;
 
    2.  Any required signature guarantees; and
 
    3.  Other supporting legal documents, if required, in the case of estates,
trusts, guardianships, custodianships, corporations, pension and profit-sharing
plans and other organizations.
 
    Redemption requests received in "good order" prior to the Pricing Time will
be executed at the net asset value computed on the date of receipt. Redemption
requests received after the Pricing Time will be executed at the next determined
net asset value. Shareholders who are uncertain of requirements for redemption
by mail should consult with a Fund representative.
 
    BY TELEPHONE.  If you have previously elected the Telephone Redemption
Option on the Account Registration Form, you can redeem Portfolio shares by
calling the Fund and requesting that the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. To change the commercial bank or account designated to receive
redemption proceeds, send a written request to the Fund at the address above.
Requests to change the bank or account must be signed by each shareholder and
 
                                       35
<PAGE>
each signature must be guaranteed. The telephone redemption option may be
difficult to implement at times, particularly during volatile market conditions.
If you experience difficulty in making a telephone redemption, you may redeem
shares by mail as described above.
 
    The Fund and the Transfer Agent will employ reasonable procedures to confirm
that instructions communicated by telephone are genuine. An investor may be
required to provide personal identification information at the time an account
is opened and prior to effecting each telephone transaction. In addition, all
telephone transaction requests will be recorded and investors may be required to
provide additional telecopied written instructions regarding transaction
requests. Neither the Fund nor the Transfer Agent will be responsible for any
loss, liability, cost or expense for following instructions received by
telephone that either of them reasonably believes to be genuine.
 
    REDEMPTION THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to accept redemption
requests from underlying beneficial owners. These redemptions may be processed
in the same way as purchases made through such Financial Intermediaries, as
described above.
 
FURTHER REDEMPTION INFORMATION
 
    The Fund normally makes payment for all shares redeemed within one business
day of receipt of the request, and in no event more than seven days after
receipt of a redemption request in good order. However, payments to investors
redeeming shares which were purchased by check will not be made until payment
for the purchase has been collected, which may take up to eight days after the
date of purchase. The Fund may suspend the right of redemption or postpone the
date upon which redemptions are effected at times when the NYSE is closed, or
under any emergency conditions as determined by the Securities and Exchange
Commission (the "Commission").
 
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of a Portfolio to make payment in
cash, the Fund may pay redemption proceeds in whole or in part by a
distribution-in-kind of readily marketable portfolio securities in accordance
with applicable rules of the Commission. Shareholders may incur brokerage
charges on the sale of portfolio securities received in payment of redemptions.
 
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required to verify the identity of the person who has authorized
certain redemptions. Please contact the Fund or see the Statement of Additional
Information for further information.
 
                         ACCOUNT POLICIES AND SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares of each Portfolio that you own for shares of any
other available portfolio(s) of the Fund, subject to certain limitations. You
cannot exchange for shares of the International Equity, Emerging Markets, Small
Cap Value Equity, Balanced or Gold Portfolios because they are currently closed
to new investors. In addition, certain portfolios may be unavailable to
shareholders who purchased portfolio shares through a Financial Intermediary.
Contact your Financial Intermediary to determine which portfolios are available
for exchange.
 
                                       36
<PAGE>
    Before you make an exchange, you should read the prospectus of the
portfolio(s) in which you seek to invest. The class of shares you receive in the
exchange will be determined in the same manner as any other purchase of shares,
including minimum initial investment and account size requirements, and will not
be based on the class of shares you surrender for the exchange. Exchange
transactions are treated as a redemption followed by a purchase. Therefore, an
exchange will be considered a taxable event for shareholders subject to tax.
Exchange transactions will be processed at the net asset value per share next
determined after receipt of the request. Shares of the portfolios may be
exchanged by mail or telephone. The telephone exchange privilege is automatic
and made available without shareholder election. The exchange privilege may be
modified or terminated by the Fund at any time upon 60-days notice to
shareholders.
 
    BY MAIL.  To exchange shares by mail, send a written exchange request to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798. Your written exchange request should include (i) the name, class of
shares and account number of your current Portfolio; (ii) the name(s) and
class(es) of shares of the portfolio(s) into which you intend to exchange
shares; and (iii) the signatures of all registered account holders.
 
    BY TELEPHONE.  To exchange shares by telephone, call the Fund at the phone
number provided on the cover of this Prospectus. A Fund representative will
request (i) the name, class of shares and account number of your current
Portfolio, and (ii) the name(s) and class(es) of shares of the portfolio(s) into
which you intend to exchange shares. For additional information regarding
responsibility for the authenticity of telephoned instructions, see "Redemption
of Shares" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by sending a written request to Morgan Stanley Institutional Fund, Inc.,
P.O. Box 2798, Boston, Massachusetts 02208-2798. It may not be possible to
transfer the registration of certain shares purchased through a Financial
Intermediary. As with redemptions, the written request must be received in "good
order" before any transfer can be made. Transferring the registration of shares
may affect the eligibility of your account for a given class of shares and may
result in involuntary conversion or redemption of your shares.
 
OTHER ACCOUNT INFORMATION
 
    The Fund does not issue share certificates for the Portfolios. All shares
purchased are confirmed to you and credited to your account on the Fund's books
maintained by the Adviser or its agents. You will have the same rights and
ownership with respect to such shares as if certificates had been issued.
 
EXCESSIVE TRADING
 
    Frequent trades in your account(s) can disrupt management of a Portfolio and
raise its expenses. Consequently, the Fund may, in its discretion and in the
interest of each Portfolio's shareholders and performance, bar a shareholder who
trades excessively from making further share purchases for an indefinite period.
The Fund considers excessive trading to be more than one purchase and sale
involving shares of the same class of a portfolio of the Fund within any 120-day
period. For example, the following series of transactions would amount to
excessive trading: exchanging shares of Portfolio A for shares of Portfolio B,
then exchanging shares of Portfolio B for shares of Portfolio C and then
exchanging shares of Portfolio C for shares of Portfolio A within a 120-day
 
                                       37
<PAGE>
period. Two types of transactions are exempt from these excessive trading
restrictions: (i) trades exclusively between money market portfolios; and (ii)
trades made in connection with an asset allocation service managed or advised by
the Adviser and/or any of its affiliates.
 
INVESTMENT IN PORTFOLIOS BY OTHER INVESTMENT ACCOUNTS
 
    Morgan Stanley or its affiliates, including Morgan Stanley Asset Management
Inc., manage investment accounts for other clients, including other investment
companies, that invest in Class A or Class B shares of the portfolios. From time
to time, one or more of the Portfolios used for investment by these accounts may
experience relatively large investments or redemptions due to investment
decisions made on behalf of these accounts. These transactions will affect the
portfolios, since portfolios that experience significant redemptions may have to
sell portfolio securities and portfolios that receive additional cash will have
to invest it in additional portfolio securities. It is impossible to predict the
overall impact of these transactions over time, however, there could be adverse
effects on portfolio management. These transactions also could have tax
consequences if sales of portfolio securities result in gains or could increase
transaction costs. The Adviser, representing the interests of the portfolios, is
committed to minimizing the impact of these transactions to the portfolios. The
Adviser, however, will have a conflict in fulfilling this responsibility in that
it also advises these investment accounts. The Adviser will monitor the impact
of these transactions on the Portfolios.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of each of the Portfolios
is determined by dividing the total market value of the Portfolio's investments
and other assets attributable to such a class, less any liabilities attributable
to such a class, by the total number of outstanding shares of each class of the
Portfolio. Net asset value is calculated separately for each class of the
Portfolios. Net asset value per share is determined as of the close of the NYSE
(normally 4:00 p.m. Eastern Time) on each day that the NYSE is open for
business. Price information on listed securities is taken from the exchange
where the security is primarily traded. Securities listed on a U.S. securities
exchange for which market quotations are available are valued at the last quoted
sale price on the day the valuation is made. Securities listed on a foreign
exchange are valued at their closing price. Unlisted securities and listed
securities not traded on the valuation date and for which market quotations are
not readily available are valued at a price within a range not exceeding the
current asked price nor less than the current bid price. The current bid and
asked prices are determined based on the average of the bid and asked prices
quoted on such valuation date by reputable brokers.
 
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily. In addition, bonds and other fixed income securities may be
valued on the basis of prices provided by a pricing service when such prices are
believed to reflect the fair market value of such securities. The prices
provided by a pricing service are determined without regard to bid or last sale
prices but take into account institutional size trading in similar groups of
securities and any developments related to the specific securities. Securities
not priced in this manner are valued at the most recently quoted bid price or,
when securities exchange valuations are used, at the latest quoted sale price on
the day of valuation. If there is no such reported sale, the latest quoted bid
price will be used. Securities purchased with remaining maturities of 60 days or
less are valued at amortized cost, if it approximates market value. In the event
that amortized cost does not approximate market value, market prices as
determined above will be used.
 
                                       38
<PAGE>
    The value of other assets and securities for which quotations are not
readily available (including restricted securities and unlisted foreign
securities) and those securities for which it is inappropriate to determine the
prices in accordance with the above-stated procedures are determined in good
faith at fair value using methods determined by the Board of Directors. For
purposes of calculating net asset value per share, all assets and liabilities
initially expressed in foreign currencies will be translated into U.S. dollars
at the mean of the bid and asked price of such currencies against the U.S.
dollar last quoted by a major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distribution expense accrual differential among the classes. The
net asset value of Class B shares will generally be lower than the net asset
value of the Class A shares as a result of the distribution expense charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise "total return" for each class of
the Small Cap Value Equity, Value Equity and Balanced Portfolios. In addition,
from time to time the Fund may advertise "yield" for the Global Fixed Income and
High Yield Portfolios. THESE FIGURES ARE BASED ON HISTORICAL EARNINGS AND ARE
NOT INTENDED TO INDICATE FUTURE PERFORMANCE.
 
    Each Portfolio may advertise "total return" which shows what an investment
in a class of a Portfolio would have earned over a specified period of time
(such as one, five or ten years) assuming that all distributions and dividends
by the Portfolio were reinvested in the same class on the reinvestment dates
during the period. Total return does not take into account any federal or state
income taxes that may be payable on dividends and distributions or on
redemption. The "yield" of the Global Fixed Income and High Yield Portfolios
refers to the income generated by an investment in the Portfolio over a month or
30-day period. This income is then annualized. That is, the amount of income
generated by the investment during that 30-day period is assumed income
generated each 30-day period for twelve periods, and is shown as a percentage of
the investment. The Fund may also include comparative performance information in
advertising or marketing the Portfolios' shares, including data from Lipper
Analytical Services, Inc., other industry publications, business periodicals,
rating service and market indices. For further information concerning these
figures, see "Calculation of Yield and Total Return"in the Statement of
Additional Information.
 
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains distributions for a class of shares
will be automatically reinvested in additional shares at net asset value, except
when, upon written notice to the Fund or by checking off the appropriate box in
the Distribution Option Section on the Account Registration Form, a shareholder
elects to receive income dividends and capital gains distributions in cash.
 
    Each Portfolio expects to distribute substantially all of its taxable net
investment income in the form of quarterly dividends. Net realized capital
gains, if any, after reduction for any available tax loss carryforwards will
also be distributed annually.
 
                                       39
<PAGE>
    Undistributed net investment income is included in a Portfolio's net assets
for the purpose of calculating net asset value per share. Therefore, on the
"ex-dividend" date, the net asset value per share excludes the dividend (i.e.,
is reduced by the per share amount of the dividend). Dividends paid shortly
after the purchase of shares by an investor, although in effect a return of
capital, are taxable to shareholders subject to tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of the Portfolios will differ at times.
Expenses of the Portfolios allocated to a particular class of shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of a Portfolio or its shareholders.
Accordingly, shareholders are urged to consult their tax advisors regarding
specific questions as to federal, state and local income taxes.
 
    Each Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other portfolios. Each Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Code so that the Portfolio will be relieved
of federal income tax on that part of its net investment income and net capital
gain that is distributed to shareholders.
 
    Each Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, net short-term capital gain) to
shareholders. Dividends from a Portfolio's net investment income are taxable to
shareholders as ordinary income, whether received in cash or in additional
shares. Such dividends paid by a Portfolio, except the High Yield and Global
Equity Portfolios, will generally qualify for the dividends-received deduction
for corporate shareholders to the extent of the aggregate qualifying dividend
income received by the Portfolio from U.S. corporations. Dividends paid by the
High Yield and Global Equity Portfolios will generally not qualify for the
dividends-received deduction for corporate shareholders.
 
    Distributions of net capital gain are taxable to shareholders as a 20% rate
gain distribution (taxed at a rate of 20%) or a 28% rate gain distribution
(taxed at a rate of 28%), depending upon the designation by the Portfolio (such
designation being dependent upon the holding period of the Portfolio in the
underlying asset generating the net capital gain), regardless of how long
shareholders have held their shares. Each Portfolio will send reports annually
to shareholders of the federal income tax status of all distributions made
during the preceding year.
 
    Each Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gains over short-term and long-term capital
loss, including any available capital loss carry-forwards), prior to the end of
each calendar year to avoid liability for federal excise tax.
 
                                       40
<PAGE>
    Dividends and other distributions declared by a Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders in that year if the distributions are paid by the Portfolio at
any time during the following January.
 
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any dividends, capital gains distributions and redemption proceeds paid to any
individual or certain other non-corporate shareholder (i) who has failed to
provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Account Registration Form; (ii) who is subject to backup withholding by the
Internal Revenue Service; or (iii) who has not certified to the Fund that such
shareholder is not subject to backup withholding. This backup withholding is not
an additional tax, and any amounts withheld may be credited against the
shareholder's ultimate U.S. tax liability.
 
    The sale, exchange or redemption of shares will result in taxable gain or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the sale, exchange or redemption proceeds exceed or are
less than the shareholder's adjusted tax basis in the sold, exchanged or
redeemed shares. If capital gains distributions have been made with respect to
shares that are sold at a loss after being held for six months or less, then the
loss is treated as a long-term capital loss to the extent of the capital gains
distributions.
 
    Conversions of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisors concerning the
application of state and local income taxes to investments in a Portfolio, which
may differ from the federal income tax consequences described above.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN A PORTFOLIO.
 
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolio
for their clients.
 
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other
 
                                       41
<PAGE>
remuneration paid to Morgan Stanley or other affiliates must be fair and
reasonable in comparison to those of other broker-dealers for comparable
transactions involving similar securities being purchased or sold during a
comparable time period.
 
PORTFOLIO TURNOVER
 
    The Portfolios generally do not invest for short-term trading purposes,
however, when circumstances warrant, each Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolios will not consider portfolio turnover rate
a limiting factor in making investment decisions consistent with their
respective objectives and policies. For the fiscal year ended December 31, 1997,
the Small Cap Value Equity, Global Fixed Income and High Yield Portfolios had
portfolio turnover rates of 178%, 116% and 111%, respectively. Higher portfolio
turnover (e.g., over 100%) necessarily will cause the Portfolios to pay
correspondingly increased brokerage and trading costs. In addition to
transaction costs, higher portfolio turnover may result in the realization of
capital gains. As discussed under "Taxes," to the extent net short-term capital
gains are realized, any distributions resulting from such gains are considered
ordinary income for federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 40 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of each
Portfolio are currently classified into two classes, the Class A shares and the
Class B shares.
 
    The shares of each Portfolio, when issued, will be fully paid,
nonassessable, fully transferable and redeemable at the option of the holder.
The shares have no preference as to conversion, exchange, dividends, retirement
or other features and have no pre-emptive rights. The shares of each Portfolio
have non-cumulative voting rights, which means that the holders of more than 50%
of the shares voting for the election of Directors can elect 100% of the
Directors if they choose to do so. Persons or organizations owning 25% or more
of the outstanding shares of a Portfolio may be presumed to "control" (as that
term is defined in the 1940 Act) such Portfolio. Under Maryland law, the Fund is
not required to hold an annual meeting of its shareholders unless required to do
so under the 1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual and semi-annual reports. The
financial statements appearing in annual reports are audited by independent
accountants. Monthly unaudited portfolio data are also available from the Fund
upon request.
 
    In addition, the Adviser or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
                                       42
<PAGE>
CUSTODIAN
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs subcustodians approved by the Board of Directors of the Fund
in accordance with regulations of the Commission for the purpose of providing
custodial services for such assets. MSTC may also hold certain domestic assets
for the Fund. For more information on the custodians, see "General Information
- -- Custody Arrangements" in the Statement of Additional Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits its annual financial statements.
 
FUND COUNSEL
 
    Morgan, Lewis & Bockius LLP acts as the Fund's legal counsel.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       43
<PAGE>
                                   APPENDIX A
                     DESCRIPTION OF CORPORATE BOND RATINGS
 
MOODY'S INVESTORS SERVICE CORPORATE BOND RATINGS:
 
    Aaa -- Bonds which are rated Aaa are judged to be of the best quality. They
carry the smallest degree of investment risk and are generally referred to as
"gilt-edged." Interest payments are protected by a large or by an exceptionally
stable margin and principal is secure. While the various protective elements are
likely to change, such changes as can be visualized are most unlikely to impair
the fundamentally strong position of such issues.
 
    Aa -- Bonds which are rated Aa are judged to be of high quality by all
standards. Together with the Aaa group they comprise what are generally known as
high-grade bonds. They are rated lower than the best bonds because margins of
protection may not be as large as in Aaa securities or fluctuation of protective
elements may be of greater amplitude or there may be other elements present
which make the long-term risks appear somewhat larger than Aaa securities.
 
    A -- Bonds which are rated A possess many favorable investment attributes
and are to be considered as upper medium grade obligations. Factors giving
security to principal and interest are considered adequate, but elements may be
present which suggest a susceptibility to impairment some time in the future.
 
    Baa -- Bonds which are rated Baa are considered as medium-grade obligations,
i.e., they are neither highly protected nor poorly secured. Interest payments
and principal security appear adequate for the present but certain protective
elements may be lacking or may be characteristically unreliable over any great
length of time. Such bonds lack outstanding investment characteristics and in
fact have speculative characteristics as well.
 
    Ba -- Bonds which are rated Ba are judged to have speculative elements;
their future cannot be considered as well assured. Often the protection of
interest and principal payments may be very moderate, and thereby not well
safeguarded during both good and bad times over the future. Uncertainty of
position characterizes bonds in this class.
 
    B -- Bonds which are rated B generally lack characteristics of the desirable
investment. Assurance of interest and principal payments or of maintenance of
other terms of the contract over any long period of time may be small.
 
    Moody's applies numerical modifiers 1, 2 and 3 in each generic rating
classification from Aa through B. The modifier 1 indicates that the security
ranks at a higher end of the rating category, modifier 2 indicates a mid-range
rating and the modifier 3 indicates that the issue ranks at the lower end of the
rating category.
 
    Caa -- Bonds which are rated Caa are of poor standing. Such issues may be in
default or there may be present elements of danger with respect to principal or
interest.
 
    Ca -- Bonds which are rated Ca represent obligations which are speculative
in a high degree. Such issues are often in default or have other marked
shortcomings.
 
    C -- Bonds which are rated C are the lowest rated class of bonds, and issues
so rated can be regarded as having extremely poor prospects of ever attaining
any real investment standing.
 
                                       44
<PAGE>
STANDARD & POOR'S RATINGS GROUP CORPORATE BOND RATINGS:
 
    AAA -- Bonds rated AAA have the highest rating assigned by Standard & Poor's
to a debt obligation and indicate an extremely strong capacity to pay principal
and interest.
 
    AA -- Bonds rated AA have a very strong capacity to pay interest and repay
principal and differ from the highest rated issues only to a small degree.
 
    A -- Bonds rated A have a strong capacity to pay interest and repay
principal although they are somewhat more susceptible to the adverse effects of
changes in circumstances and economic conditions than bonds in higher rated
categories.
 
    BBB -- Debt rated BBB is regarded as having an adequate capacity to pay
interest and repay principal. Whereas they normally exhibit adequate protection
parameters, adverse economic conditions or changing circumstances are more
likely to lead to a weakened capacity to pay interest and repay principal for
debt in this category than for debt in higher rated categories.
 
    BB, B, CCC, CC and C -- Debt rated BB, B, CCC, CC and C is regarded, on
balance, as predominantly speculative with respect to capacity to pay interest
and repay principal in accordance with the terms of the obligation. BB indicates
the lowest degree of speculation and C the highest degree of speculation. While
such debt will likely have some quality and protective characteristics, these
are outweighed by large uncertainties or major risk exposures to adverse
conditions.
 
    C -- The rating C may be used to cover a situation where a bankruptcy
petition has been filed or similar action has been taken, but payments on this
obligation are being continued.
 
    D -- Debt rated D is in default, and payment of interest and/or repayment of
principal is in arrears.
 
                                       45
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
        SMALL CAP VALUE EQUITY, VALUE EQUITY, BALANCED, GLOBAL FIXED INCOME AND
        HIGH YIELD PORTFOLIOS
        P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                            <C>
      ACCOUNT INFORMATION                            If you need assistance in filling out this form for the Morgan Stanley
      Fill in where applicable                       Institutional Fund, Inc., please contact your Morgan Stanley
                                                     representative or call us toll free 1-800-548-7786. Please print all
                                                     items except signature, and mail to the Fund at the address above.
 
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
         TENANCY IN COMMON
         IS INDICATED)
</TABLE>
 
1.
- --------------------------------------------------------------------------------
         First Name    Initial         Last Name
 
2.
- --------------------------------------------------------------------------------
         First Name    Initial         Last Name
 
- --------------------------------------------------------------------------------
         First Name    Initial         Last Name
 
<TABLE>
<C>   <S>                                            <C>
      3. CORPORATIONS,
         TRUSTS AND OTHERS
         Please call the Fund for additional
      documents that may be required to set up
      account and to authorize transactions.
</TABLE>
 
3.
 
- --------------------------------------------------------------------------------
 
- --------------------------------------------------------------------------------
 
- --------------------------------------------------------------------------------
 
<TABLE>
<S>                     <C>                 <C>                   <C>               <C>
Type of Registration:   / / INCORPORATED    / / UNINCORPORATED    / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                            ASSOCIATION                               (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
<TABLE>
<C>        <S>                           <C>
       B)  MAILING ADDRESS
           Please fill in completely,
           including telephone number(s).
 
<CAPTION>
       B)
 
<CAPTION>
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
 
/ / Non-Resident Alien
 
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
 
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
<PAGE>
 
<TABLE>
<C>   <S>                                            <C>                                  <C>
  C)  TAXPAYER                                       Enter your Taxpayer Identification Number. For most individual
      IDENTIFICATION                                 taxpayers, this is your Social Security Number.
      NUMBER
      1. INDIVIDUAL
      2.   JOINT TENANTS
      (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
      TENANCY IN COMMON
      IS INDICATED)
      For Custodian account
      of a minor (Uniform
      Gifts/Transfers to Minor
      Acts), give the Social
      Security Number of
      the minor.
                                                                                          OR
                                                     1.         TAXPAYER IDENTIFICATION                      SOCIAL SECURITY
                                                     NUMBER ("TIN")                                NUMBER ("SSN")
                                                                                              OR
                                                     2.                              TIN
                                                                                                                             SSN
                                                                                              OR
                                                     TIN
                                                                                                                             SSN
 
                                                     IMPORTANT TAX INFORMATION
                                                     You (as a payee) are required by law to provide us (as payer) with your
                                                     correct TIN(s) or SSN(s). Accounts that have a missing or incorrect
                                                     TIN(s) or SSN(s) will be subject to backup withholding at a 31% rate on
                                                     dividends, distributions and other payments. If you have not provided us
                                                     with your correct TIN(s) or SSN(s), you may be subject to a $50 penalty
                                                     imposed by the Internal Revenue Service.
                                                     Backup withholding is not an additional tax; the tax liability of
                                                     persons subject to backup withholding will be reduced by the amount of
                                                     tax withheld. If withholding results in an overpayment of taxes, a
                                                     refund may be obtained.
                                                     You may be notified that you are subject to backup withholding under
                                                     Section 3406(a)(1)(C) of the Internal Revenue Code because you have
                                                     underreported interest or dividends or you were required to, but failed
                                                     to, file a return which would have included a reportable interest or
                                                     dividend payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>                             <C>                   <C>
  D)  PORTFOLIO AND                        For Purchase of the following   / / Class A Shares $  / / Class B Shares $
      CLASS SELECTION                      Portfolio(s):                   / / Class A Shares $  / / Class B Shares $
      (Class A shares minimum $500,000     Small Cap Value Equity          / / Class A Shares $  / / Class B Shares $
      for each Portfolio and Class B       Portfolio                       / / Class A Shares $  / / Class B Shares $
      shares minimum $100,000 for each     Value Equity Portfolio          / / Class A Shares $  / / Class B Shares $
      Portfolio. Please indicate           Balanced Portfolio
      Portfolio, class and amount.         Global Fixed Income Portfolio
                                           High Yield Portfolio
                                                                           Total Initial Investment $
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate portfolio
      and manner of payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                          <C>
/ / Exchange $ From                                                                     - - - - - - - - - - - -- - -
                            Name of Portfolio                                Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on                 -- - - - - - - - - - -- - -
                                                                                      Account No.               (Check
                                                                                (Previously assigned by the Fund)     Digit)
                                                                                                                          Date
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  F)  DISTRIBUTION               Income dividends and capital gains distributions (if any) to
      OPTION                     be reinvested in additional shares unless either box below
                                 is checked.
                                 / / Income dividends to be paid in cash, capital gains
                                 distributions (if any) in shares.
                                 / / Income dividends and capital gains distributions (if
                                 any) to be paid in cash.
</TABLE>
 
<TABLE>
<C>   <S>                             <C>                                       <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone         Name of COMMERCIAL Bank (Not Savings
      AND EXCHANGE                    requests to wire redemption proceeds to   Bank)
      OPTION                          the commercial bank indicated at right    Bank Account No.
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund
      wish to redeem or exchange      account is registered if such requests                                        Bank
      shares by telephone. A          are believed to be authentic.                                                  ABA
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent                                         No.
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated    Name(s) in which your Bank Account is
      YOUR FUND ACCOUNT.              by telephone are genuine. These           Established
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal      Bank's Street
      NOT BE HONORED UNLESS THE BOX   identification information at the time    Address
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by   City  State  Zip
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  H)  INTERESTED PARTY
      OPTION                                                                                                Name
      In addition to the account
      statement sent to my/our registered
      address, I/we hereby authorize the                                                                   Address
      Fund to mail duplicate statements
      to the name and address provided at  City         State         Zip Code
      right.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  I)  DEALER
      INFORMATION
                                           Representative Name              Representative No.             Branch
                                           No.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here ,
</TABLE>
 
<TABLE>
<S>                                  <C>
The undersigned certify that I/we have full authority and legal capacity
to purchase and redeem shares of the Fund and affirm that I/we have
received a current Prospectus of the Morgan Stanley Institutional Fund,
Inc. and agree to be bound by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF
PERJURY THAT THE INFORMATION ON THIS APPLICATION IS COMPLETE AND CORRECT
AND THAT AS REQUIRED BY FEDERAL LAW (PLEASE CHECK APPLICABLE BOXES
BELOW):
 
/ / U.S. CITIZEN(S)/TAXPAYER(S):
 
      / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM
          IS/ARE THE CORRECT SSN(S) OR TIN(S) AND (2) I/WE ARE NOT
          SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE ARE
          EXEMPT FROM BACKUP WITHHOLDING; (B) I/WE HAVE NOT BEEN
          NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT I/WE ARE
          SUBJECT TO BACKUP WITHHOLDING AS A RESULT OF A FAILURE TO
          REPORT ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED
          ME/US THAT I AM/WE ARE NO LONGER SUBJECT TO BACKUP
          WITHHOLDING.
 
      / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE HAVE
          APPLIED, OR INTEND TO APPLY, TO THE IRS OR THE SOCIAL SECURITY
          ADMINISTRATION FOR A TIN OR A SSN AND I/WE UNDERSTAND THAT IF
          I/ WE DO NOT PROVIDE EITHER NUMBER TO CHASE GLOBAL FUNDS
          SERVICES COMPANY ("CGFSC") WITHIN 60 DAYS OF THE DATE OF THIS
          APPLICATION OR IF I/WE FAIL TO FURNISH MY/OUR CORRECT SSN(S)
          OR TIN(S), I/WE MAY BE SUBJECT TO A PENALTY AND A 31% BACKUP
          WITHHOLDING ON DISTRIBUTIONS AND REDEMPTION PROCEEDS. (PLEASE
          PROVIDE EITHER NUMBER ON IRS FORM W-9). YOU MAY REQUEST SUCH
          FORM BY CALLING CGFSC AT 800-282-4404.
 
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
  UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S.
CITIZENS OR RESIDENTS AND I/WE ARE EXEMPT FOREIGN PERSONS AS DEFINED BY
THE INTERNAL REVENUE SERVICE.
 
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY
PROVISION OF THIS DOCUMENT OTHER THAN THE CERTIFICATIONS REQUIRED TO
AVOID BACKUP WITHHOLDING.
 
                                     (X)
(X)                                  Signature (if joint account, both
Signature            Date            must sign)      Date
</TABLE>
<PAGE>
  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<S>                                                 <C>
                                                    PAGE
                                                    ----
Fund Expenses.....................................    2
Financial Highlights..............................    4
Prospectus Summary................................   10
Investment Objectives and Policies................   15
Additional Investment Information.................   19
Investment Limitations............................   28
Management of the Fund............................   28
Purchase of Shares................................   32
Redemption of Shares..............................   35
Account Policies and Services.....................   36
Valuation of Shares...............................   38
Performance Information...........................   39
Dividends and Capital Gains Distributions.........   39
Taxes.............................................   40
Portfolio Transactions............................   41
General Information...............................   42
Appendix A -- Description of Corporate Bond
 Ratings..........................................   44
Account Registration Form
</TABLE>
 
                        SMALL CAP VALUE EQUITY PORTFOLIO
                             VALUE EQUITY PORTFOLIO
                               BALANCED PORTFOLIO
                         GLOBAL FIXED INCOME PORTFOLIO
                              HIGH YIELD PORTFOLIO
 
                               PORTFOLIOS OF THE
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
 
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  Incorporated
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
                      P.O BOX 2798, BOSTON, MA 02208-2798
<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
     ----------------------------------------------------------------------
 
                      ACTIVE COUNTRY ALLOCATION PORTFOLIO
 
                               A PORTFOLIO OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
 
                                ----------------
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a series of diversified and non-diversified investment portfolios
("portfolios"). The Fund is designed to provide clients with attractive
alternatives for meeting their investment needs. The Fund currently consists of
thirty-two portfolios representing a broad range of investment choices. This
prospectus (the "Prospectus") pertains to the Class A and the Class B shares of
the Active Country Allocation Portfolio (the "Portfolio"). The Class A and Class
B shares currently offered by the Portfolio have different minimum investment
requirements and fund expenses. Shares of the Portfolio are offered with no
sales charge, exchange fee or redemption fee.
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator"), and with Morgan Stanley & Co. Incorporated ("Morgan Stanley")
as Distributor, the Fund makes available to institutional and high net worth
individual investors a series of portfolios which benefit from the investment
expertise and commitment to excellence associated with Morgan Stanley and its
affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under "Prospectus Summary" below. The Fund
currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging Markets,
European Equity, European Real Estate, Global Equity, International Equity,
International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) EQUITY AND FIXED INCOME -- Balanced
Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global
Fixed Income, High Yield, and Municipal Bond Portfolios; and (v) MONEY MARKET --
Money Market and Municipal Money Market Portfolios. Additional information about
the Fund is contained in a "Statement of Additional Information," dated May 1,
1998, which is incorporated herein by reference. The Statement of Additional
Information and the prospectuses pertaining to the other portfolios of the Fund
are available upon request and without charge by writing or calling the Fund at
the address and telephone number set forth above.
 
THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
    EXCHANGE COMMISSION, NOR HAS THE SECURITIES AND EXCHANGE COMMISSION
       PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS.  ANY
             REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
                  THE DATE OF THIS PROSPECTUS IS MAY 1, 1998.
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates the expenses and fees that a shareholder of
the Active Country Allocation Portfolio will incur:
 
<TABLE>
<CAPTION>
SHAREHOLDER TRANSACTION EXPENSES
- ------------------------------------------------------------------------------------------
<S>                                                                                         <C>
Maximum Sales Load Imposed on Purchases
  Class A.................................................................................        None
  Class B.................................................................................        None
Maximum Sales Load Imposed on Reinvested Dividends
  Class A.................................................................................        None
  Class B.................................................................................        None
Deferred Sales Load
  Class A.................................................................................        None
  Class B.................................................................................        None
Redemption Fees
  Class A.................................................................................        None
  Class B.................................................................................        None
Exchange Fees
  Class A.................................................................................        None
  Class B.................................................................................        None
</TABLE>
 
<TABLE>
<CAPTION>
ANNUAL FUND OPERATING EXPENSES
 (AS A PERCENTAGE OF AVERAGE NET ASSETS)
- ------------------------------------------------------------------------------------------
<S>                                                                                         <C>
Management Fee (Net of Fee Waiver)*
  Class A.................................................................................       0.35%
  Class B.................................................................................       0.35%
12b-1 Fees
  Class A.................................................................................        None
  Class B.................................................................................       0.25%
Other Expenses
  Class A.................................................................................       0.45%
  Class B.................................................................................       0.45%
                                                                                            -----------
Total Operating Expenses (Net of Fee Waivers)*
  Class A.................................................................................       0.80%
  Class B.................................................................................       1.05%
                                                                                            -----------
                                                                                            -----------
</TABLE>
 
- ------------------------
*The Adviser has agreed to waive its management fees and/or to reimburse the
 Portfolio, if necessary, if such fees would cause the total annual operating
 expenses of the Portfolio to exceed a specified percentage of its average daily
 net assets. Absent the fee waiver, the management fee would be 0.65%. Absent
 the fee waiver and/or expense reimbursement, the Portfolio's total operating
 expenses would be 1.10% of the average daily net assets of the Class A shares
 and 1.32% of the average daily net assets of the Class B shares. As a result of
 this reduction, the Management Fee stated above is lower than the contractual
 fee stated under "Management of the Fund." The Adviser reserves the right to
 terminate any of its fee waivers and/or expense reimbursements at any time in
 its sole discretion. For further information on Fund expenses, see "Management
 of the Fund."
 
                                       2
<PAGE>
    The purpose of the table above is to assist the investor in understanding
the various expenses that an investor in the Portfolio will bear directly or
indirectly. Expenses and fees are based on actual figures for the fiscal year
ended December 31, 1997. Due to the continuous nature of Rule 12b-1 fees,
long-term Class B shareholders may pay more than the equivalent of the maximum
front-end sales charges otherwise permitted by the National Association of
Securities Dealers, Inc. ("NASD") Conduct Rules.
 
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (i) a 5% annual rate of return, and (ii) redemption
at the end of each time period. As noted in the table above, the Fund charges no
redemption fees of any kind. The following example is based on the total
operating expenses of the Portfolio after fee waivers.
 
<TABLE>
<CAPTION>
                                                                       1 YEAR       3 YEARS      5 YEARS     10 YEARS
                                                                     -----------  -----------  -----------  -----------
<S>                                                                  <C>          <C>          <C>          <C>
Active Country Allocation Portfolio
  Class A..........................................................   $       8    $      26    $      44    $      99
  Class B..........................................................          11           33           58          128
</TABLE>
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. ACTUAL EXPENSES MAY BE GREATER OR LESS THAN THOSE
SHOWN.
 
                                       3
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following table provides financial highlights for the Class A and Class
B shares of the Active Country Allocation Portfolio. The audited financial
highlights for the Portfolio's shares for each of the periods in the five years
ended December 31, 1997 are part of the Fund's financial statements which appear
in the Fund's December 31, 1997 Annual Report to Shareholders and which are
incorporated by reference into the Fund's Statement of Additional Information.
The Portfolio's financial highlights for each of the periods presented have been
audited by Price Waterhouse LLP, whose unqualified report thereon is also
incorporated by reference into the Statement of Additional Information.
Additional performance information is included in the Annual Report. The Annual
Report and the financial statements therein, along with the Statement of
Additional Information, are available at no cost from the Fund at the address
and telephone number noted on the cover page of this Prospectus. After October
31, 1992 (the Fund's prior fiscal year end), the Fund changed its fiscal year
end to December 31. The following information should be read in conjunction with
the financial statements and notes thereto.
 
                                       4
<PAGE>
                      ACTIVE COUNTRY ALLOCATION PORTFOLIO
<TABLE>
<CAPTION>
                                                           CLASS A
            -----------------------------------------------------------------------------------------------------
                                                                                                      PERIOD FROM
                                                                                        TWO MONTHS    JANUARY 17,
                                     YEAR ENDED DECEMBER 31                               ENDED        1992* TO
            ------------------------------------------------------------------------   DECEMBER 31,   OCTOBER 31,
               1997++          1996           1995           1994           1993           1992          1992
            ------------   ------------   ------------   ------------   ------------   ------------   -----------
<S>         <C>            <C>            <C>            <C>            <C>            <C>            <C>
NET ASSET
 VALUE,
 BEGINNING
 OF
 PERIOD...    $  11.44       $  11.63       $  11.65       $  12.21       $   9.59       $  9.37        $ 10.00
            ------------   ------------   ------------   ------------   ------------   ------------   -----------
INCOME
 FROM
INVESTMENT
OPERATIONS
  Net
Investment
Income (1)...       0.18         0.24           0.17           0.19           0.13          0.02           0.11
  Net
  Realized
   and
Unrealized
   Gain
   (Loss)
   on
   Investments...       0.80       0.88         1.00          (0.25)          2.75          0.20          (0.74)
            ------------   ------------   ------------   ------------   ------------   ------------   -----------
    Total
     from
Investment
Operations...       0.98         1.12           1.17          (0.06)          2.88          0.22          (0.63)
            ------------   ------------   ------------   ------------   ------------   ------------   -----------
DISTRIBUTIONS
  Net
Investment
 Income...       (0.83)         (0.81)         (0.25)         (0.14)         (0.09)           --             --
  In
   Excess
   of Net
Investment
  Income..       (0.02)         (0.02)         (0.10)            --          (0.08)           --             --
  Net
  Realized
   Gain...       (1.18)         (0.48)         (0.84)         (0.36)            --            --             --
  In
   Excess
   of Net
  Realized
   Gain...          --             --             --             --          (0.09)           --             --
            ------------   ------------   ------------   ------------   ------------   ------------   -----------
    Total
    Distributions...      (2.03)      (1.31)      (1.19)      (0.50)         (0.26)           --             --
            ------------   ------------   ------------   ------------   ------------   ------------   -----------
NET ASSET
 VALUE,
 END OF
 PERIOD...    $  10.39       $  11.44       $  11.63       $  11.65       $  12.21       $  9.59        $  9.37
            ------------   ------------   ------------   ------------   ------------   ------------   -----------
            ------------   ------------   ------------   ------------   ------------   ------------   -----------
TOTAL
 RETURN...        8.61%          9.71%         10.57%         (0.52)%        30.72%         2.35%         (6.30)%
            ------------   ------------   ------------   ------------   ------------   ------------   -----------
            ------------   ------------   ------------   ------------   ------------   ------------   -----------
RATIOS AND
SUPPLEMENTAL
 DATA:
  Net
   Assets,
   End of
   Period
   (Thousands)..   $138,667   $183,193      $170,663       $182,977       $150,854       $50,234        $47,534
  Ratio of
  Expenses
   to
   Average
   Net
   Assets
   (1)....        0.80%          0.80%          0.80%          0.80%          0.80%         0.80%**        0.88%**
  Ratio of
   Net
Investment
   Income
   to
   Average
   Net
   Assets (1)...       1.47%       1.22%        1.26%          1.43%          1.29%         1.22%**        2.32%**
 Portfolio
  Turnover
   Rate...          49%            65%            72%            51%            53%            2%            62%
  Average
Commission
   Rate
   Per
 Share #..     $0.0019       $ 0.0028            N/A            N/A            N/A           N/A            N/A
- ----------------------------------
  Average
Commission
   Rate as
   a
Percentage
   of
   Trade
   Amount #...       0.11%       0.11%           N/A            N/A            N/A           N/A            N/A
 
(1) Effect
     of
 voluntary
   expense
limitation
    during
     the
   period:
      Per
     share
   benefit
       to
       net
investment
 income...       $0.03          $0.03          $0.05          $0.03          $0.05         $0.01          $0.03
   Ratios
    before
   expense
   limitation:
  Expenses
       to
   Average
       Net
 Assets...        1.10%          1.09%          1.18%          1.00%          1.33%         1.70%**        1.58%**
      Net
Investment
    Income
       to
   Average
       Net
 Assets...        1.18%          0.94%          0.88%          1.23%          0.76%         0.32%**        1.62%**
 
<CAPTION>
                      CLASS B
            ---------------------------
                           PERIOD FROM
                            JANUARY 2,
             YEAR ENDED     1996*** TO
            DECEMBER 31,   DECEMBER 31,
               1997++          1996
            ------------   ------------
<S>         <C>            <C>
NET ASSET
 VALUE,
 BEGINNING
 OF
 PERIOD...    $  11.44       $ 11.66
            ------------   ------------
INCOME
 FROM
INVESTMENT
OPERATIONS
  Net
Investment
Income (1)        0.08          0.06
  Net
  Realized
   and
Unrealized
   Gain
   (Loss)
   on
   Investm        0.87          1.00
            ------------   ------------
    Total
     from
Investment
Operations        0.95          1.06
            ------------   ------------
DISTRIBUTI
  Net
Investment
 Income...       (0.71)        (0.78)
  In
   Excess
   of Net
Investment
  Income..       (0.02)        (0.02)
  Net
  Realized
   Gain...       (1.18)        (0.48)
  In
   Excess
   of Net
  Realized
   Gain...          --            --
            ------------   ------------
    Total
    Distri       (1.91)        (1.28)
            ------------   ------------
NET ASSET
 VALUE,
 END OF
 PERIOD...    $  10.48       $ 11.44
            ------------   ------------
            ------------   ------------
TOTAL
 RETURN...        8.35%         9.22%
            ------------   ------------
            ------------   ------------
RATIOS AND
SUPPLEMENT
 DATA:
  Net
   Assets,
   End of
   Period
   (Thousa         $14          $633
  Ratio of
  Expenses
   to
   Average
   Net
   Assets
   (1)....        1.05%         1.05%**
  Ratio of
   Net
Investment
   Income
   to
   Average
   Net
   Assets         0.71%         1.09%**
 
 Portfolio
  Turnover
   Rate...          49%           65%
  Average
Commission
   Rate
   Per
 Share #..     $0.0019       $0.0028
- ----------
  Average
Commission
   Rate as
   a
Percentage
   of
   Trade
   Amount         0.11%         0.11%
(1) Effect
     of
 voluntary
   expense
limitation
    during
     the
   period:
      Per
     share
   benefit
       to
       net
investment
 income...       $0.03         $0.02
   Ratios
    before
   expense
   limitat
 
  Expenses
       to
   Average
       Net
 Assets...        1.32%         1.33%**
      Net
Investment
    Income
       to
   Average
       Net
 Assets...        0.45%         0.82%**
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 ** Annualized
*** The Portfolio began offering Class B shares on January 2, 1996.
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period.
 ++ Per share amounts for the year ended December 31, 1997 are based on average
    shares outstanding.
 
                                       5
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and high net worth individual investors a broad range of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates providing customized services as Adviser, Administrator and
Distributor. Each portfolio offers Class A shares and Class B shares, except the
International Small Cap and Municipal Money Market Portfolios, which offer only
Class A shares. Each portfolio has its own investment objective and policies
designed to meet its specific goals. The investment objective of the Portfolio
described in this Prospectus is as follows:
 
    -The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
     appreciation by investing in accordance with country weightings determined
     by the Adviser in equity securities of non-U.S. issuers which, in the
     aggregate, replicate broad country indices.
 
    The other portfolios of the Fund are described in other prospectuses which
may be obtained from the Fund at the address and phone number noted on the cover
page of this Prospectus. The investment objectives of these other portfolios are
listed below:
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    -The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Asian issuers.
 
    -The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
     appreciation by investing primarily in equity securities of companies in
     the Asian real estate industry.
 
    -The CHINA GROWTH PORTFOLIO seeks to provide long-term capital appreciation
     by investing primarily in equity securities of issuers in The People's
     Republic of China, Hong Kong and Taiwan.
 
    -The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of emerging country issuers.
 
    -The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of European issuers.
 
    -The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income and
     long-term capital appreciation by investing primarily in equity securities
     of companies in the European real estate industry.
 
    -The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers throughout the world,
     including U.S. issuers.
 
    -The GOLD PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of foreign and domestic issuers engaged in
     gold-related activities.
 
    -The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers.
 
    -The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers domiciled in
     EAFE countries.
 
    -The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
     by investing primarily in the equity securities of non-U.S. issuers with
     equity market capitalizations of less than $1 billion.
 
                                       6
<PAGE>
    -The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Japanese issuers.
 
    -The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Latin American issuers and,
     from time to time, debt securities issued or guaranteed by Latin American
     governments or governmental entities.
 
    U.S. EQUITY:
 
    -The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by investing
     primarily in corporate equity and equity-linked securities.
 
    -The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing primarily in growth-oriented equity securities of small- to
     medium-sized corporations.
 
    -The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing in growth-oriented equity securities of medium and large
     capitalization companies.
 
    -The MICROCAP PORTFOLIO seeks long-term capital appreciation by investing
     primarily in growth-oriented equity securities of small corporations.
 
    -The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total return by
     investing in equity securities of small- to medium-sized companies which
     the Adviser believes to be undervalued.
 
    -The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of companies that, in the opinion of the
     Adviser, are expected to benefit from their involvement in technology and
     technology-related industries.
 
    -The U.S. EQUITY PLUS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers included in the
     Standard & Poor's 500 Index ("S&P 500").
 
    -The U.S. REAL ESTATE PORTFOLIO seeks to provide above-average current
     income and long-term capital appreciation by investing primarily in equity
     securities of companies in the U.S. real estate industry, including
     substantial investment in real estate investment trusts.
 
    -The VALUE EQUITY PORTFOLIO seeks high total return by investing in equity
     securities which the Adviser believes to be undervalued relative to the
     stock market in general at the time of purchase.
 
    EQUITY AND FIXED INCOME:
 
    -The BALANCED PORTFOLIO seeks high total return while preserving capital by
     investing in a combination of equity securities which the Adviser believes
     to be undervalued and fixed income securities.
 
    FIXED INCOME:
 
    -The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by investing
     primarily in debt securities of government, government-related and
     corporate issuers located in emerging countries.
 
    -The FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
     with the preservation of capital by investing in a diversified portfolio of
     fixed income securities.
 
    -The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
     of return while preserving capital by investing in fixed income securities
     of issuers throughout the world, including U.S. issuers.
 
    -The HIGH YIELD PORTFOLIO seeks to maximize total return by investing in a
     diversified portfolio of high yield fixed income securities that offer a
     yield above that generally available on debt securities in the four highest
     rating categories of the recognized rating services.
 
                                       7
<PAGE>
    -The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a level
     of current income as is consistent with the preservation of capital by
     investing primarily in a variety of investment grade mortgage-backed
     securities.
 
    -The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of current
     income consistent with preservation of principal by investing in municipal
     obligations, the interest on which is exempt from federal income tax.
 
    MONEY MARKET:
 
    -The MONEY MARKET PORTFOLIO seeks to maximize current income and preserve
     capital while maintaining high levels of liquidity through investing in
     high quality money market instruments with remaining maturities of one year
     or less.
 
    -The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current tax-exempt
     income and preserve capital while maintaining high levels of liquidity
     through investing in high quality money market instruments with remaining
     maturities of one year or less which are exempt from federal income tax.
 
   THE CHINA GROWTH, GOLD, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS
   ARE CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley Dean Witter & Co., acts as investment adviser to the Fund and each of
its portfolios. As of March 31, 1998, Morgan Stanley Asset Management Inc. and
its affiliated institutional asset management companies managed assets of
approximately $166 billion, including assets under fiduciary advice. See
"Management of the Fund -- Investment Adviser" and "Management of the Fund --
Administrator."
 
HOW TO INVEST
 
    Class A shares of the Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of the
Portfolio are offered at net asset value with no sales commission, but with a
12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25% of the
Class B shares' average daily net assets on an annualized basis. The minimum
initial investment, generally, is $500,000 for Class A shares of the Portfolio
and $100,000 for Class B shares of the Portfolio. The minimum initial investment
amount is reduced for certain categories of investors. For additional
information on how to purchase shares and minimum initial investments, see
"Purchase of Shares".
 
HOW TO REDEEM
 
    Class A shares or Class B shares of the Portfolio may be redeemed at any
time, without cost, at the net asset value per share of the applicable class
next determined after receipt of the redemption request. The redemption price
may be more or less than the purchase price. Certain redemptions that cause the
value of an account to remain for a continuous 60-day period below the minimum
investment amount for Class A shares or for Class B shares may result in
involuntary redemption or automatic conversion. For additional information on
how to redeem shares and involuntary redemption or conversion, see "Purchase of
Shares" and "Redemption of Shares."
 
                                       8
<PAGE>
RISK FACTORS
 
    Investing in the Portfolio entails certain risks and considerations of which
an investor should be aware. The Portfolio's share price and investment returns
fluctuate and, when redeemed, an investment in the Portfolio may be worth more
or less than its original cost. The investment policies of the Portfolio may
entail the following risk factors:
 
    -EQUITY SECURITIES. The Portfolio will invest in equity securities. Prices
     of equity securities fluctuate in response to many factors, including the
     financial health of the issuers and changes in economic and market
     conditions.
 
    -FOREIGN INVESTMENT. The Portfolio may invest in the securities of foreign
     issuers. The risks of foreign investment include fluctuations in foreign
     currency values, political events affecting the country of issuance and
     potentially greater market volatility and lower liquidity.
 
    -EMERGING MARKET COUNTRY SECURITIES. The Portfolio may invest in emerging
     market country securities which entail risks typically associated with
     investment in more established foreign markets. However, these risks may be
     intensified due to higher volatility and less liquidity of emerging
     markets, possible political risks associated with the country of issuance
     and generally weaker financial condition of issuers in these markets.
 
    -DERIVATIVES. The Portfolio may invest in instruments that derive their
     values from those of specified securities, indices, currencies or other
     points of reference. These derivatives, including those used to manage
     risk, are themselves subject to the risks of the different markets in which
     they are traded and, therefore, may or may not serve their intended
     purposes.
 
For additional information about risk factors, see also "Investment Objectives
and Policies" and "Additional Investment Information."
 
                                       9
<PAGE>
                       INVESTMENT OBJECTIVE AND POLICIES
 
    The investment objective of the Portfolio is to provide long-term capital
appreciation by investing in accordance with country weightings determined by
the Adviser in equity securities of non-U.S. issuers which, in the aggregate,
replicate broad country indices. The Adviser utilizes a top-down approach in
selecting investments for the Portfolio that emphasizes country selection and
weighting rather than individual stock selection. This approach reflects the
Adviser's philosophy that a diversified selection of securities representing
exposure to world markets, based upon the economic outlook and current valuation
levels for each country, is an effective way to maximize the return and minimize
the risk associated with international investment. The Portfolio's investment
objective is a fundamental policy which may not be changed without the approval
of a majority of the Portfolio's outstanding voting securities. There is no
assurance that the Portfolio will attain its objective. The investment policies
described below are not fundamental policies unless otherwise noted and may be
changed without shareholder approval.
 
    The Adviser determines country allocations for the Portfolio on an ongoing
basis within policy ranges dictated by each country's market capitalization and
liquidity. The Portfolio will invest in the industrialized countries throughout
the world that comprise the Morgan Stanley Capital International EAFE (Europe,
Australia and the Far East) Index. The Portfolio will not invest in the stocks
of U.S. issuers. The Portfolio will also invest in securities of issuers located
in emerging countries. With respect to the Portfolio, the term "emerging
country" applies to any country which, in the opinion of the Adviser, is
generally considered to be an emerging country by the international financial
community, including the International Bank for Reconstruction and Development
(more commonly known as the World Bank) and the International Finance
Corporation. There are currently over 150 countries which, in the opinion of the
Adviser, are generally considered to be emerging countries by the international
financial community. These countries generally include every nation in the world
except the United States, Canada, Japan, Australia, New Zealand and most nations
located in Western Europe. The Portfolio will focus its investments on those
emerging market countries in which it believes the economies are developing
strongly and in which the markets are becoming more sophisticated. With respect
to the portion of the Portfolio that is invested in emerging country equity
securities, the Portfolio currently intends to invest primarily in some or all
of the following countries:
 
<TABLE>
<S>              <C>
Argentina        Philippines
Brazil           South Africa
India            South Korea
Indonesia        Thailand
Malaysia         Turkey
Mexico
</TABLE>
 
As markets in other countries develop, the Portfolio expects to expand and
further diversify the emerging countries in which it invests. The Portfolio does
not intend to invest in any security in a country where the currency is not
freely convertible to U.S. dollars, unless the Portfolio has obtained the
necessary governmental licensing to convert such currency or other appropriately
licensed or sanctioned contractual guarantee to protect such investment against
loss of that currency's external value, or the Portfolio has a reasonable
 
                                       10
<PAGE>
expectation at the time the investment is made that such governmental licensing
or other appropriately licensed or sanctioned guarantee would be obtained or
that the currency in which the security is quoted would be freely convertible at
the time of any proposed sale of the security by the Portfolio.
 
    By analyzing a variety of macroeconomic and political factors, the Adviser
develops fundamental projections on interest rates, currencies, corporate
profits and economic growth for each country. These country projections are used
then to determine what the Adviser believes to be a fair value for the stock
market of each country. Discrepancies between actual value and fair value as
determined by the Adviser provide an expected return for each stock market. The
expected return is adjusted by currency return expectations derived from the
Adviser's purchasing-power parity exchange rate model to arrive at an expected
total return in U.S. dollars. The final country allocation decision is then
arrived at by considering the expected total return in light of various country
specific considerations such as market size, volatility, liquidity and country
risk.
 
    Within a particular country, investments are made through the purchase of
equity securities which, in aggregate, replicate a broad market index, which in
most cases will be the Morgan Stanley Capital International index for the given
country. The Portfolio invests primarily in equity securities, which include
common and preferred stock, convertible securities and rights and warrants to
purchase common stocks. The Adviser may overweight or underweight an industry
segment of a particular index if it concludes this would be advantageous to the
Portfolio. An issuer may be considered to be from a particular country if, in
the opinion of the Adviser, it has one or more of the following characteristics:
(i) its principal securities trading market is in that country; (ii) alone or on
a consolidated basis it derives 50% or more of its annual revenue from either
goods produced, sales made or services performed in that country; or (iii) it is
organized under the laws of, and has a principal office in, that country. The
Adviser will base determinations as to eligibility on publicly available
information and inquiries made to the companies. Indexation of the Portfolio's
stock selection reduces stock-specific risk through diversification and
minimizes transaction costs, which can be substantial in foreign markets. In
addition to the investments and strategies described below, the Portfolio may
invest in certain securities and obligations as set forth in "Additional
Investment Information" below.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    FIXED INCOME SECURITIES.  The Portfolio will invest in fixed income (debt)
securities. The market value of the fixed income securities in which the
Portfolio invests will be affected by changes in the creditworthiness of issuers
and will change in response to interest rate changes and other factors.
Generally, the values of fixed income securities vary inversely with changes in
interest rates, so that during periods of falling interest rates, the values of
outstanding fixed income securities generally rise and during periods of rising
interest rates, the values of such securities generally decline. While
securities with longer maturities tend to produce higher yields, the prices of
longer maturity securities are subject to greater market fluctuations as a
result of changes in interest rates.
 
    FOREIGN CURRENCY FORWARD CONTRACTS.  The Portfolio may enter into foreign
currency forward contracts ("forward contracts") that provide for the purchase
or sale of an amount of a specified currency at a future date. The Portfolio may
use such contracts to protect against a decline in a foreign currency against
the U.S. dollar between the trade date and settlement date when the Portfolio
purchases or sells securities, lock in the U.S.
 
                                       11
<PAGE>
dollar value of dividends and interest on securities held by the Portfolio, and
generally to protect the U.S. dollar value of securities held by the Portfolio
against exchange rate fluctuation. While forward contracts may limit losses as a
result of exchange rate fluctuations, they will also limit any gains that might
otherwise have been realized. The Portfolio's Custodian may be required to place
cash or liquid securities in a segregated account in an amount equal to the
value of the Portfolio's total assets committed to the consummation of forward
contracts. If the value of the securities placed in the segregated account
declines, additional cash or securities will be placed in the account on a daily
basis so that the value of the account will be at least equal to the amount of
the Portfolio's commitments with respect to such contracts.
 
    FOREIGN INVESTMENT.  The Portfolio may invest in the securities of foreign
issuers. Investment in securities of foreign issuers involves investment risks
somewhat different from those affecting securities of U.S. issuers. The
Portfolio's investments will be subject to political and economic events that
affect the countries in which it invests. Foreign issuers may be subject to
different accounting, auditing and financial standards and requirements. There
also may be less government supervision and regulation of foreign securities
exchanges, brokers and listed companies than in the United States. Many foreign
securities markets have substantially less trading volume than U.S. national
securities exchanges and, therefore, securities of some foreign issuers are less
liquid and more volatile than securities of comparable U.S. issuers. Brokerage
commissions and other transaction costs on foreign securities exchanges are
generally higher than in the United States. Dividends and interest paid by
foreign issuers may be subject to withholding and other foreign taxes, which may
decrease the net return on foreign investments as compared to dividends and
interest paid to the Portfolio by domestic companies. Investments in securities
of foreign issuers are generally denominated in foreign currencies and, since
the Portfolio may temporarily hold uninvested reserves in bank deposits in
foreign currencies, the value of the Portfolio's assets as measured in U.S.
dollars may be affected favorably or unfavorably by changes in currency exchange
rates and exchange control regulations, and the Portfolio may incur costs in
connection with conversions between various currencies.
 
    The Portfolio may also invest in emerging market country securities.
Investing in emerging markets entails the risks associated with foreign
investment described above, however, these risks may be intensified in emerging
markets. Emerging markets can include every nation in the world except the
United States, Canada, Japan, Australia, New Zealand and most nations located in
Western Europe. Certain emerging market countries have historically experienced,
and may continue to experience, high rates of inflation, high interest rates,
exchange rate fluctuations, large amounts of external debt, trade difficulties
and unemployment. Further, the economies of developing countries generally are
heavily dependent upon international trade and, accordingly, have been, and may
continue to be, adversely affected by trade barriers, exchange controls and
other protectionist measures imposed or negotiated by the countries in which
they trade. There also are risks associated with the possibility of
nationalization, expropriation or confiscatory taxation, political changes,
government regulation, social instability or diplomatic developments (including
war) that could adversely affect the economies of such countries or the value of
the Portfolio's investments in those countries.
 
    LOANS OF PORTFOLIO SECURITIES.  The Portfolio may lend its securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing net investment income. These loans must be secured
continuously by cash or equivalent collateral or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be risks of delay in recovery of the
 
                                       12
<PAGE>
securities or even loss of rights in the collateral should the borrower of the
securities fail financially. The Portfolio will not enter into securities loan
transactions exceeding in the aggregate 33 1/3% of the market value of the
Portfolio's total assets.
 
    MONEY MARKET INSTRUMENTS.  The Portfolio is permitted to invest in money
market instruments, although the Portfolio intends to stay invested in
securities satisfying its primary investment objective to the extent practical.
Consistent with its investment policies, the Portfolio may make money market
investments pending other investment or settlement for liquidity. In addition,
the Portfolio may invest in money market instruments for temporary defensive
purposes during adverse market conditions. The money market investments
permitted for the Portfolio include: obligations of the U.S. Government and its
agencies and instrumentalities, obligations of foreign sovereignties, commercial
paper, bank obligations (including certificates of deposit), other debt
securities and repurchase agreements.
 
    REPURCHASE AGREEMENTS.  The Portfolio may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines adopted by the
Fund's Board of Directors. In a repurchase agreement, the Portfolio buys a
security from a seller that has agreed to repurchase it at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of the
agreement. The term of these agreements is usually from overnight to one week
and never exceeds one year. A repurchase agreement may be viewed as a fully
collateralized loan of money by the Portfolio to the seller. The Portfolio
always receives securities with a market value at least equal to the purchase
price (including accrued interest) as collateral and this value is maintained
during the term of the agreement. If the seller defaults and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with respect to the seller, the Portfolio's realization upon the
collateral may be delayed or limited. The Portfolio may not enter into
repurchase agreements with more than seven days to maturity if, as a result,
more than 10% of the market value of the Portfolio's net assets would be
invested in such repurchase agreements and other investments for which market
quotations are not readily available or which are otherwise illiquid.
 
    TEMPORARY INVESTMENTS.  During periods in which the Adviser believes changes
in economic, financial or political conditions make it advisable, the Portfolio
may, for temporary defensive purposes, invest up to 100% of its total assets in
certain short-term and medium-term debt obligations or hold cash. The short-term
and medium-term debt obligations in which the Portfolio may invest consist of
(i) obligations of the U.S. or foreign governments, their respective agencies or
instrumentalities; (ii) money market instruments; and (iii) instruments
denominated in any currency issued by international development agencies.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  The Portfolio may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Delivery of and payment for these securities may take
as long as a month or more after the date of the purchase commitment but will
take place no more than 120 days after the trade date. The Portfolio will
maintain with the Custodian a segregated account of cash or liquid securities in
an amount at least equal to these commitments. The payment obligation and the
interest rates that will be received are each fixed at the time the Portfolio
enters into the commitment and no interest accrues to the Portfolio until
settlement. Thus, it is possible that the market value at the time of settlement
could be higher or lower than the purchase price if the general
 
                                       13
<PAGE>
level of interest rates has changed. It is a current policy of the Portfolio not
to enter into when-issued commitments exceeding, in the aggregate, 15% of the
market value of the Portfolio's total assets less liabilities other than the
obligations created by these commitments.
 
DERIVATIVE PRODUCTS (DERIVATIVES)
 
    The Portfolio is permitted to utilize various exchange-traded and
over-the-counter derivative instruments and derivative securities, both for
hedging and non-hedging purposes. Permitted derivative products include, but are
not limited to: futures contracts ("futures"); forward contracts ("forwards");
options; swaps, caps, collars and floors; structured notes; and other derivative
products yet to be developed, so long as these new products are used in a manner
consistent with the objective of the Portfolio. These derivative products may be
based upon a wide variety of underlying rates, indices, instruments, securities
and other products, such as interest rates, foreign currencies, foreign and
domestic fixed income and equity securities, groups or "baskets" of securities
and securities indices (for each derivative product, the "underlying").
Exclusive of forward foreign currency contracts and any derivative products used
for hedging purposes, the Portfolio will limit its use of derivative products to
33 1/3% of its total assets, measured by the aggregate notional amount of
outstanding derivative products.
 
    The Portfolio may use derivative products under a number of different
circumstances to further its investment objective. For example, the Portfolio
may purchase derivatives to gain exposure to a market quickly in response to
changes in the Portfolio's investment strategy, upon the inflow of investable
cash or when the derivative provides greater liquidity than the underlying
market. The Portfolio may also use derivatives when it is restricted from
directly owning the "underlying" or when derivatives provide a pricing advantage
or lower transaction costs. The Portfolio also may purchase combinations of
derivatives in order to gain exposure to an investment in lieu of actually
purchasing such investment. Derivatives may also be used by the Portfolio for
hedging or risk management purposes and in other circumstances when the Adviser
believes it advantageous to do so consistent with the Portfolio's investment
objective and policies. The Portfolio will not use derivatives in a manner that
creates leverage, except to the extent that the use of leverage is expressly
permitted by the Portfolio's investment policies, and then only in a manner
consistent with such policies.
 
    The use of derivative products is a highly specialized activity which
involves investment techniques and risks different from those associated with
ordinary portfolio securities transactions. If the Adviser is incorrect in
forecasts of market values, interest rates, and currency exchange rates, the
investment performance of the Portfolio will be less favorable than it would
have been if these investment techniques had not been used.
 
    Some of the derivative products in which the Portfolio may invest and some
of the risks related thereto are described in more detail below.
 
FUTURES CONTRACTS (FUTURES) AND FORWARD CONTRACTS (FORWARDS)
 
    The Portfolio may purchase and sell futures contracts, such as futures on
securities indices, baskets of securities, foreign currencies and interest rates
of the type generally known as financial futures. These are standardized
contracts that are bought and sold on organized exchanges. A futures contract
obligates a party to buy or sell a specific amount of the "underlying," such as
for example, a particular foreign currency, on a specified future date at a
specified price or to settle the value in cash.
 
                                       14
<PAGE>
    The Portfolio may also purchase and sell forward contracts, such as forward
rate agreements and other financial forward contracts. The Portfolio may also
use foreign currency forward contracts which are separately discussed elsewhere
in this Prospectus. See "Foreign Currency Forward Contracts" above. These
forward contracts are privately negotiated and are bought and sold in the
over-the-counter market. Like a future, a forward contract obligates a party to
buy or sell a specific amount of the underlying on a specified future date at a
specified price. The terms of the forward contract are customized. Forward
contracts, like other over-the-counter contracts that are negotiated directly
with an individual counterparty, subject the Portfolio to the risk of
counterparty default.
 
    In some cases, the Portfolio may be able to use either futures contracts,
forward contracts or exchange-traded or over-the-counter options to accomplish
similar purposes. In all cases, the Portfolio will use these products only as
permitted by applicable laws and regulations. Some of the ways in which the
Portfolio may utilize futures contracts, forward contracts and related options
are as follows:
 
    The Portfolio may sell securities index futures contracts and/or index
options thereon in anticipation of or during a market decline to attempt to
offset the decrease in market value of investments in its portfolio, or may
purchase securities index futures or options in order to gain market exposure.
There currently are limited securities index futures and options on such futures
in many countries, particularly emerging countries. The nature of the strategies
adopted by the Adviser, and the extent to which those strategies are used, may
depend on the development of such markets. The Portfolio may also purchase and
sell foreign currency futures to hedge its respective holdings and commitments
against changes in the level of future currency rates or to adjust its exposure
to a particular currency.
 
    The Portfolio may engage in transactions in interest rate futures and
related products. The value of these contracts rises and falls inversely with
changes in interest rates. The Portfolio may engage in such transactions to
hedge its holdings of debt instruments against future changes in interest rates
or for other purposes.
 
    The Portfolio may also purchase or sell futures and forwards on other
financial instruments, such as U.S. Government securities and certificates of
deposit. The value of these contracts also rises and falls inversely with
changes in interest rates. The Portfolio may engage in financial futures and
forward contracts for both hedging and non-hedging purposes.
 
    Gains and losses on futures contracts, forward contracts and related options
depend on the Adviser's ability to predict correctly the direction of securities
prices, interest rates and other economic factors. Other risks associated with
the use of these instruments include (i) imperfect correlation between the
change in market value of investments held by the Portfolio and the prices of
derivative products relating to investments purchased or sold by the Portfolio,
and (ii) possible lack of a liquid secondary market for a derivative product and
the resulting inability to close out a position. The risk that the Portfolio
will be unable to close out a position will be minimized by only entering into
transactions for which there appears to be a liquid exchange or secondary
market. In some strategies, the risk of loss in trading on futures and related
transactions can be substantial, due both to the low margin deposits required
and the extremely high degree of leverage involved in pricing.
 
    Under rules adopted by the Commodity Futures Trading Commission (the
"CFTC"), the Portfolio may, without registering with the CFTC as a Commodity
Pool Operator, enter into futures contracts and options
 
                                       15
<PAGE>
thereon for both hedging and non-hedging purposes, provided that not more than
5% of the Portfolio's total assets at the time of entering the transaction are
required as margin and option premiums to secure obligations under such
contracts relating to non-bona fide hedging activities.
 
OPTION TRANSACTIONS
 
    The Portfolio may seek to increase its returns or may hedge its portfolio
investments through options transactions with respect to individual securities,
indices or baskets in which the Portfolio may invest; other financial
instruments; and foreign currency. Various options may be purchased and sold on
either the exchange-traded or over-the-counter markets.
 
    The Portfolio may purchase put and call options. Purchasing a put option
gives the Portfolio the right, but not the obligation, to sell the underlying
(such as a securities index or a particular foreign currency) at the exercise
price either on a specific date or during a specified exercise period.
Purchasing a call option gives the Portfolio a similar right, but not the
obligation, to purchase the underlying. The purchaser pays a premium to the
seller (also known as the writer) of the option.
 
    The Portfolio also may write put and call options on investments held in its
portfolio, as well as foreign currency options. The Portfolio that has written
an option receives a premium that increases the Portfolio's return on the
underlying in the event the option expires unexercised or is closed out at a
profit. However, by writing a call option, the Portfolio will limit its
opportunity to profit from an increase in the market value of the underlying
above the exercise price of the option. By writing a put option, the Portfolio
will be exposed to the amount by which the price of the underlying is less than
the strike price.
 
    By writing an option, the Portfolio incurs an obligation either to buy (in
the case of a put option) or sell (in the case of a call option) the underlying
from the purchaser of the option at the option's exercise price, upon exercise
by the purchaser. Pursuant to guidelines established by the Board of Directors,
the Portfolio may only write options that are "covered." A covered call option
means that until the expiration of the option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will continue to own (i) the underlying; (ii) securities or instruments
convertible or exchangeable without the payment of any consideration into the
underlying; or (iii) a call option on the same underlying with a strike price no
higher than the price at which the underlying was sold pursuant to a short
option position. In the case of a put option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will own another put option on the same underlying with an equal or higher
strike price.
 
    There currently are limited options markets in many countries, particularly
emerging market countries, and the nature of the strategies adopted by the
Adviser and the extent to which those strategies are used will depend on the
development of these options markets. The primary risks associated with the
Portfolio's use of options as described include (i) imperfect correlation
between the change in market value of investments held, purchased or sold by the
Portfolio and the prices of options relating to such investments, and (ii)
possible lack of a liquid secondary market for an option.
 
                                       16
<PAGE>
INTEREST RATE, CURRENCY, COMMODITY AND EQUITY SWAPS, CAPS, COLLARS AND FLOORS
 
    Swaps are privately negotiated over-the-counter derivative products in which
two parties agree to exchange payment streams calculated in relation to a rate,
index, instrument or certain securities and a particular "notional amount." As
with many of the other derivative products available to the Portfolio, the
underlying may include an interest rate (fixed or floating), a currency exchange
rate, a commodity price index, and a security, securities index or a combination
thereof. A great deal of flexibility is possible in the way the products may be
structured, with the effect being that the parties may have exchanged amounts
equal to the return on one rate, index or group of securities for another. For
example, in a simple fixed-to-floating interest rate swap, one party makes
payments equivalent to a fixed interest rate, and the other makes payments
equivalent to a specified interest rate index. The Portfolio may engage in
simple or more complex swap transactions involving a wide variety of
underlyings. The currency swaps that the Portfolio may enter will generally
involve an agreement to pay interest streams in one currency based on a
specified index in exchange for receiving interest streams denominated in
another currency. Such swaps may involve initial and final exchanges that
correspond to the agreed upon notional amount.
 
    Caps, collars and floors are privately-negotiated option-based derivative
products. The Portfolio may use one or more of these products in addition to or
in lieu of a swap involving a similar rate or index. As in the case of a put or
call option, the buyer of a cap or floor pays a premium to the writer. In
exchange for that premium, the buyer receives the right to a payment equal to
the differential if the specified index or rate rises above (in the case of a
cap) or falls below (in the case of a floor) a pre-determined strike level. As
in the case of swaps, obligations under caps and floors are calculated based
upon an agreed notional amount, and like most swaps (other than foreign currency
swaps), the entire notional amount is not exchanged and thus is not at risk. A
collar is a combination product in which the same party, such as the Portfolio,
buys a cap from and sells a floor to the other party. As with put and call
options, the amount at risk is limited for the buyer, but, if the cap or floor
is not hedged or covered, may be unlimited for the seller. Under current market
practice, caps, collars and floors between the same two parties are generally
documented under the same "master agreement." In some cases, options and forward
agreements may also be governed by the same master agreement. In the event of a
default, amounts owed under all transactions entered into under, or covered by,
the same master agreement would be netted and only a single payment would be
made.
 
    Swaps, caps, collars and floors are credit-intensive products. When the
Portfolio enters into a swap transaction it bears the risk of default, i.e.
nonpayment, by the other party. The guidelines under which the Portfolio enters
derivative transactions, along with some features of the transactions
themselves, are intended to reduce these risks to the extent reasonably
practicable, although they cannot eliminate the risks entirely. Under guidelines
established by the Board of Directors, the Portfolio may enter into swaps only
with parties that meet certain credit rating guidelines. Consistent with current
market practices, the Portfolio will generally enter into swap transactions on a
net basis, and all swap transactions with the same party will be documented
under a single master agreement to provide for net payment upon default. In
addition, the Portfolio's obligations under an agreement will be accrued daily
(offset against any amounts owing to the Portfolio) and any accrued, but unpaid,
net amounts owed to the other party to a master agreement will be covered by the
maintenance of a segregated account consisting of cash or liquid securities.
 
                                       17
<PAGE>
    Interest rate and total rate of return (fixed income or equity) swaps
generally do not involve the delivery of securities, other underlying assets, or
principal. In such case, if the other party to an interest rate or total rate of
return swap defaults, the Portfolio's risk of loss will consist of the payments
that the Portfolio is contractually entitled to receive from the other party.
This may not be true for currency swaps that require the delivery of the entire
notional amount of one designated currency in exchange for the other. If there
is a default by the other party, the Portfolio may have contractual remedies
pursuant to the agreements related to the transaction.
 
STRUCTURED NOTES
 
    Structured notes are derivative securities for which the amount of principal
repayment and/or interest payments is based upon the movement of one or more
factors. These factors include, but are not limited to, currency exchange rates,
interest rates (such as the prime lending rate and LIBOR) and stock indices,
such as the S&P 500. In some cases, the impact of the movements of these factors
may increase or decrease through the use of multipliers or deflators. The
Portfolio may use structured notes to tailor its investments to the specific
risks and returns the Adviser wishes to accept while avoiding or reducing
certain other risks.
 
                             INVESTMENT LIMITATIONS
 
    As a diversified investment company, the Portfolio is subject to the
following limitations: (i) as to 75% of its total assets, the Portfolio may not
invest more than 5% of its total assets in the securities of any one issuer,
except obligations of the U.S. Government and its agencies and
instrumentalities, and (ii) the Portfolio may not own more than 10% of the
outstanding voting securities of any one issuer.
 
    The Portfolio also operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of the
holders of a majority of the Portfolio's outstanding shares and under certain
non-fundamental investment limitations that may be changed without shareholder
approval. For additional information on fundamental and non-fundamental
investment limitations, see "Investment Limitations" in Statement of Additional
Information.
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and the Portfolio. The Adviser provides investment
advice and portfolio management services pursuant to an Investment Advisory
Agreement and, subject to the supervision of the Fund's Board of Directors,
makes each of the Portfolio's day-to-day investment decisions, arranges for the
execution of portfolio transactions and generally manages the Portfolio's
investments. The Adviser is entitled to receive from the Active Country
Allocation Portfolio an annual management fee, payable quarterly, equal to 0.65%
of the average daily net assets of the Portfolio.
 
    The fees of the Portfolio are higher than those of most investment
companies' because the Portfolio invests internationally. The Adviser believes
that the fees are comparable to those of other investment companies that invest
internationally. The Adviser has voluntarily agreed to a reduction in the fees
payable to it and to reimburse
 
                                       18
<PAGE>
the Portfolio, if necessary, if such fees would cause total annual operating
expenses of the Portfolio to exceed 0.80% of the average daily net assets of the
Class A shares of the Portfolio and 1.05% of the average daily net assets of the
Class B shares of the Portfolio.
 
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to customers in the
United States and abroad. Morgan Stanley Dean Witter & Co. ("MSDW") is the
direct parent of the Adviser and Morgan Stanley. MSDW is a preeminent global
financial services firm that maintains leading market positions in each of its
three primary businesses -- securities, asset management and credit services. At
March 31, 1998, the Adviser, together with its affiliated institutional asset
management companies, managed assets of approximately $166 billion, including
assets under fiduciary advice. See "Management of the Fund" in the Statement of
Additional Information.
 
    PORTFOLIO MANAGERS.  ANN D. THIVIERGE AND BARTON M. BIGGS. Ann D. Thivierge
is a Principal of the Adviser. She is a member of the Adviser's asset allocation
committee, primarily representing the Total Fund Management team since its
inception in 1991. Prior to joining the Adviser in 1986, she spent two years at
Edgewood Management Company, a privately held investment management firm. Ms.
Thivierge holds a B.A. in International Relations from James Madison College,
Michigan State University, and an M.B.A. in Finance from New York University.
Barton M. Biggs has been Chairman and a director of the Adviser since 1980 and a
Managing Director of Morgan Stanley since 1975. He is also a director and
chairman of various registered investment companies to which the Adviser and
certain of its affiliates provide investment advisory services. Mr. Biggs holds
a B.A. from Yale University and an M.B.A. from New York University. Ms.
Thivierge and Mr. Biggs have shared primary responsibility for managing the
Portfolio since June, 1995.
 
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the officers and the
Board of Directors of the Fund and include day-to-day administration of matters
related to the corporate existence of the Fund, maintenance of its records,
preparation of reports, supervision of the Fund's arrangements with its
custodian and assistance in the preparation of the Fund's registration
statements under federal laws. The Administration Agreement also provides that
the Administrator, through its agents, will provide dividend disbursing and
transfer agent services to the Fund. For its services under the Administration
Agreement, the Fund pays the Adviser a monthly fee which on an annual basis
equals 0.15% of the average daily net assets of the Portfolio.
 
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors such administrative services provided by CGFSC.
Their services are also subject to the supervision of the Board of Directors of
the Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
                                       19
<PAGE>
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of the Fund upon the terms and at the current offering
price described in this Prospectus. Morgan Stanley is not obligated to sell any
certain number of shares of the Portfolio.
 
    The Portfolio currently offers only the classes of shares offered by this
Prospectus. The Portfolio may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares pursuant to Rule 12b-1 under the Investment Company Act of 1940, as
amended (the "1940 Act") (the "Plan"). Under the Plan, the Distributor is
entitled to receive from the Portfolio a distribution fee, which is accrued
daily and paid quarterly, of 0.25% of the Class B shares' average daily net
assets on an annualized basis. Each Plan is designed to compensate the
Distributor for its services in connection with distribution assistance. The
Distributor may retain any portion of the fee that it does not expend in meeting
its obligations to the Fund. The Distributor may compensate financial
intermediaries, plan fiduciaries and administrators for providing
distribution-related services, including account maintenance services, to
shareholders (including, where applicable, underlying beneficial owners) of
Class B shares.
 
    EXPENSES.  The Portfolio is responsible for payment of certain other fees
and expenses (including legal fees, accountants' fees, custodial fees and
printing and mailing costs) as specified in its agreements with the Adviser and
Morgan Stanley.
 
    YEAR 2000.  The management and distribution services provided to the Fund by
the Adviser and Morgan Stanley depend on the smooth functioning of their
computer systems. Many computer software systems in use today cannot recognize
the year 2000, but revert to 1900 or some other date, due to the manner in which
dates were encoded and calculated. That failure could have a negative impact on
the handling of securities trades, pricing and account services. The Adviser and
Morgan Stanley have been actively working on necessary changes to their own
computer systems to deal with the year 2000 problem and expect that their
systems will be adapted before that date. There can be no assurance, however,
that they will be successful. In addition, other unaffiliated service providers
may be faced with similar problems. The Adviser and Morgan Stanley are
monitoring their remedial efforts, however, there can be no assurance that they
and the services they provide will not be adversely affected.
 
    In addition, it is possible that the markets for securities in which the
Portfolio invests may be detrimentally affected by computer failures throughout
the financial services industry beginning January 1, 2000. Improperly
functioning trading systems may result in settlement problems and liquidity
issues. In addition, corporate and governmental data processing errors may
result in production problems for individual companies and overall economic
uncertainties. Earnings of individual issuers will be affected by remediation
costs, which may be substantial and may be reported inconsistently in U.S. and
foreign financial statements. Accordingly, the Portfolio's investments may be
adversely affected.
 
                                       20
<PAGE>
                               PURCHASE OF SHARES
 
    Class A shares and Class B shares of the Portfolio may be purchased at the
net asset value per share next determined after receipt by the Fund of a
purchase order as described under "Methods of Purchase." The net asset value per
share of the Portfolio is calculated on days that the New York Stock Exchange
("NYSE") and Chase (the "Custodian Bank") are open for business as of the close
of trading of the NYSE, normally 4:00 p.m. Eastern Time (the "Pricing Time").
 
MINIMUM INVESTMENT
 
    The minimum initial investment is $500,000 for Class A shares and $100,000
for Class B shares of the Portfolio. These minimums may be waived at the
discretion of the Adviser for certain types of investors, including trust
departments, brokers, dealers, agents, financial planners, financial services
firms, investment advisers or various retirement and deferred compensation plans
("Financial Intermediaries"), certain accounts managed by the Adviser and its
affiliates ("Managed Accounts"), and certain employees and customers of Morgan
Stanley and its affiliates. The Fund's determination of an investor's
eligibility to purchase shares of a given class will take precedence over the
investor's selection of a class.
 
METHODS OF PURCHASE
 
    Shares may be purchased directly from the Fund by Federal Funds wire, by
bank wire or by check. Investors may also invest in the Portfolio by purchasing
shares through Financial Intermediaries that have made arrangements with Morgan
Stanley. Some Financial Intermediaries may charge an additional service or
transaction fee. If a purchase is canceled due to nonpayment or because your
check does not clear, you will be responsible for any loss the Fund or its
agents incur. If you are already a shareholder, the Fund may redeem shares from
your account(s) to reimburse the Fund or its agents for any loss. In addition,
you may be prohibited or restricted from making future investments in the Fund.
 
    FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire Federal
Funds to the Fund's bank account. Federal Funds purchase orders will be accepted
only on a day on which the Fund and the Custodian Bank are open for business.
Your bank may charge a service fee for wiring Federal Funds. In order to ensure
proper handling of your purchase by Federal Funds wire, please follow these
steps:
 
    1. Place your order by telephoning the Fund at 1-800-548-7786. A Fund
       representative will request certain purchase information and provide you
       with a confirmation number.
 
    2. Instruct your bank to wire the specified amount to the Fund's Wire
       Concentration Bank Account as follows:
 
       The Chase Manhattan Bank
     One Manhattan Plaza
     New York, NY 10081-1000
     ABA# 021000021
     DDA# 910-2-733293
     Attn: Morgan Stanley Institutional Fund, Inc.
     Ref: (Portfolio name, your account number, your account name)
 
       Please call the Fund at 1-800-548-7786 prior to wiring the funds.
 
                                       21
<PAGE>
    3. Complete and sign the Account Registration Form and mail it to the
       address shown thereon.
 
    When a purchase order is received prior to the Pricing Time and Federal
Funds are received prior to the close of the Federal Funds Wire Control Center
("FFWCC") (normally 6:00 p.m. Eastern Time), the purchase will be executed at
the net asset value computed on the date of receipt. Purchases for which an
order is received after the Pricing Time or for which Federal Funds are received
after the close of the FFWCC, will be executed at the net asset value next
determined. Certain institutional investors and financial institutions have
entered into an arrangement with Morgan Stanley, pursuant to which they may
place orders prior to the Pricing Time, but make payment in Federal Funds for
those shares on the following business day.
 
    BANK WIRE.  A purchase of shares by bank wire must follow the same procedure
as for a Federal Funds wire, described above. However, depending on the time the
bank wire is sent and which bank is handling the wire, money transferred by bank
wire may or may not be converted into Federal Funds prior to the close of the
FFWCC. Prior to conversion to Federal Funds and receipt by the Fund, an
investor's money will not be invested.
 
    CHECK.  An account may be opened by completing and signing an Account
Registration Form and mailing it, together with a check payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio name]" to:
 
    Morgan Stanley Institutional Fund, Inc.
    P.O. Box 2798
    Boston, Massachusetts 02208-2798
 
    The Fund ordinarily is credited with Federal Funds within one business day
of deposit of a check. Thus, a purchase of shares by check ordinarily will be
credited to your account at the net asset value per share determined on the next
business day after receipt. An investor's money will not be invested prior to
crediting of Federal Funds.
 
    INVESTMENT THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to receive purchase and
redemption orders from underlying beneficial owners, such as retirement plan
participants, generally on each business day. Each business evening, the
Financial Intermediary aggregates all orders received from underlying beneficial
owners prior to the Pricing Time on that business day and places a net purchase
and/or redemption order(s) by the morning of the next business day. These orders
normally are executed at the net asset value that was computed for the Portfolio
as of the close of the previous business day.
 
    ADDITIONAL INVESTMENTS.  You may purchase additional shares for your account
at any time by purchasing shares at net asset value by any of the methods
described above. The minimum additional investment generally is $1,000 for the
Portfolio. The minimum additional investment may be lower for certain accounts,
described above under "Minimum Investment." For purchases directly from the
Fund, your account name, the Portfolio name and the class selected must be
specified in the letter or wire to assure proper crediting to your account.
 
INVOLUNTARY CONVERSION AND REDEMPTION OF NEW ACCOUNT SHARES
 
    Class A and Class B shares of the Portfolio may be subject to the
involuntary conversion and redemption features described below. The conversion
and redemption features may be waived at the discretion of the Adviser for
shares held in a Managed Account and shares purchased through a Financial
Intermediary. Accounts
 
                                       22
<PAGE>
that were open prior to January 2, 1996 are not subject to involuntary
conversion or redemption. The Fund reserves the right to modify or terminate the
conversion or redemption features of the shares at any time upon 60 days notice
to shareholders.
 
    CONVERSION FROM CLASS A TO CLASS B SHARES.  If the value of an account
containing Class A shares falls below $500,000 (but remains at or above
$100,000) because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $500,000 (but remains at or
above $100,000) for a continuous 60-day period, the Class A shares in such
account will convert to Class B shares and will be subject to the distribution
fee and other features applicable to Class B shares. The Fund will not convert
Class A shares to Class B shares based solely upon changes in the market that
reduce the net asset value of shares. Under current tax law, conversion between
share classes is not a taxable event to the shareholder.
 
    CONVERSION FROM CLASS B TO CLASS A SHARES.  If the value of an account
containing Class B shares increases to $500,000 or more, whether due to
shareholder purchases or market activity, the Class B shares will convert to
Class A shares. Class B shares purchased through a Financial Intermediary that
has entered into an arrangement with the Fund for the purchase of such shares
may not be converted. Under current tax law, such conversion is not a taxable
event to the shareholder. Class A shares converted from Class B shares are
subject to the same minimum account size requirements as are applicable to New
Accounts containing Class A shares described above.
 
    INVOLUNTARY REDEMPTION OF SHARES.  If the value of an account falls below
$100,000 because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $100,000 for a continuous
60-day period, the shares in such account will be subject to redemption by the
Fund. The Fund will not redeem shares based solely upon changes in the market
that reduce the net asset value of shares. If redeemed, redemption proceeds will
be promptly paid to the shareholder.
 
                              REDEMPTION OF SHARES
 
    Class A and Class B shares of the Portfolio may be redeemed at any time and
without charge at the net asset value per share next determined after receipt by
the Fund of a redemption order as described under "Methods of Redemption."
Redemption proceeds may be more or less than the purchase price of your shares
depending on, among other factors, the market value of the investment securities
held by the Portfolio.
 
METHODS OF REDEMPTION
 
    Shares may be redeemed directly from the Fund by mail or by telephone.
However, shares purchased through a Financial Intermediary must be redeemed
through a Financial Intermediary. Certain Financial Intermediaries may charge an
additional service or transaction fee.
 
    BY MAIL.  The Portfolio will redeem shares upon receipt of a redemption
request in "good order." Redemption requests may be sent by regular mail to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798 or, by overnight courier, to Morgan Stanley Institutional Fund, Inc.,
c/o Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913.
 
                                       23
<PAGE>
    "Good order" means that the request to redeem shares must include the
following:
 
    1. A letter of instruction or a stock assignment specifying the class and
       number of shares or dollar amount to be redeemed, signed by all
       registered owners of the shares in the exact names in which they are
       registered;
 
    2. Any required signature guarantees; and
 
    3. Other supporting legal documents, if required, in the case of estates,
       trusts, guardianships, custodianships, corporations, pension and
       profit-sharing plans and other organizations.
 
    Redemption requests received in "good order" prior to the Pricing Time will
be executed at the net asset value computed on the date of receipt. Redemption
requests received after the Pricing Time will be executed at the next determined
net asset value. Shareholders who are uncertain of requirements for redemption
by mail should consult with a Fund representative.
 
    BY TELEPHONE.  If you have previously elected the Telephone Redemption
Option on the Account Registration Form, you can redeem Portfolio shares by
calling the Fund and requesting that the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. To change the commercial bank or account designated to receive
redemption proceeds, send a written request to the Fund at the address above.
Requests to change the bank or account must be signed by each shareholder and
each signature must be guaranteed. The telephone redemption option may be
difficult to implement at times, particularly during volatile market conditions.
If you experience difficulty in making a telephone redemption, you may redeem
shares by mail as described above.
 
    The Fund and the Transfer Agent will employ reasonable procedures to confirm
that instructions communicated by telephone are genuine. An investor may be
required to provide personal identification information at the time an account
is opened and prior to effecting each telephone transaction. In addition, all
telephone transaction requests will be recorded and investors may be required to
provide additional telecopied written instructions regarding transaction
requests. Neither the Fund nor the Transfer Agent will be responsible for any
loss, liability, cost or expense for following instructions received by
telephone that either of them reasonably believes to be genuine.
 
    REDEMPTION THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to accept redemption
requests from underlying beneficial owners. These redemptions may be processed
in the same way as purchases made through such Financial Intermediaries, as
described above.
 
FURTHER REDEMPTION INFORMATION
 
    The Fund normally makes payment for all shares redeemed within one business
day of receipt of the request, and in no event more than seven days after
receipt of a redemption request in good order. However, payments to investors
redeeming shares which were purchased by check will not be made until payment
for the purchase has been collected, which may take up to eight days after the
date of purchase. The Fund may suspend the right of redemption or postpone the
date upon which redemptions are effected at times when the NYSE is closed, or
under any emergency conditions as determined by the Securities and Exchange
Commission (the "Commission").
 
                                       24
<PAGE>
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of the Portfolio to make payment in
cash, the Fund may pay redemption proceeds in whole or in part by a
distribution-in-kind of readily marketable portfolio securities in accordance
with applicable rules of the Commission. Shareholders may incur brokerage
charges on the sale of portfolio securities received in payment of redemptions.
 
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required to verify the identity of the person who has authorized
certain redemptions. Please contact the Fund or see the Statement of Additional
Information for further information.
 
                         ACCOUNT POLICIES AND SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares of the Portfolio that you own for shares of any
other available portfolio(s) of the Fund, subject to certain limitations. You
cannot exchange for shares of the International Equity, Emerging Markets, Small
Cap Value Equity, Balanced or Gold Portfolios because they are currently closed
to new investors. In addition, certain portfolios may be unavailable to
shareholders who purchased portfolio shares through a Financial Intermediary.
Contact your Financial Intermediary to determine which portfolios are available
for exchange.
 
    Before you make an exchange, you should read the prospectus of the
portfolio(s) in which you seek to invest. The class of shares you receive in the
exchange will be determined in the same manner as any other purchase of shares,
including minimum initial investment and account size requirements, and will not
be based on the class of shares you surrender for the exchange. Exchange
transactions are treated as a redemption followed by a purchase. Therefore, an
exchange will be considered a taxable event for shareholders subject to tax.
Exchange transactions will be processed at the net asset value per share next
determined after receipt of the request. Shares of the portfolios may be
exchanged by mail or telephone. The telephone exchange privilege is automatic
and made available without shareholder election. The exchange privilege may be
modified or terminated by the Fund at any time upon 60-days notice to
shareholders.
 
    BY MAIL.  To exchange shares by mail, send a written exchange request to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798. Your written exchange request should include (i) the name, class of
shares and account number of your current Portfolio; (ii) the name(s) and
class(es) of shares of the portfolio(s) into which you intend to exchange
shares; and (iii) the signatures of all registered account holders.
 
    BY TELEPHONE.  To exchange shares by telephone, call the Fund at the phone
number provided on the cover of this Prospectus. A Fund representative will
request (i) the name, class of shares and account number of your current
Portfolio, and (ii) the name(s) and class(es) of shares of the portfolio(s) into
which you intend to exchange shares. For additional information regarding
responsibility for the authenticity of telephoned instructions, see "Redemption
of Shares" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by sending a written request to Morgan Stanley Institutional Fund, Inc.,
P.O. Box 2798, Boston, Massachusetts 02208-2798. It may
 
                                       25
<PAGE>
not be possible to transfer the registration of certain shares purchased through
a Financial Intermediary. As with redemptions, the written request must be
received in "good order" before any transfer can be made. Transferring the
registration of shares may affect the eligibility of your account for a given
class of shares and may result in involuntary conversion or redemption of your
shares.
 
OTHER ACCOUNT INFORMATION
 
    The Fund does not issue share certificates for the Portfolio. All shares
purchased are confirmed to you and credited to your account on the Fund's books
maintained by the Adviser or its agents. You will have the same rights and
ownership with respect to such shares as if certificates had been issued.
 
EXCESSIVE TRADING
 
    Frequent trades in your account(s) can disrupt management of the Portfolio
and raise its expenses. Consequently, the Fund may, in its discretion and in the
interest of the Portfolio's shareholders and performance, bar a shareholder who
trades excessively from making further share purchases for an indefinite period.
The Fund considers excessive trading to be more than one purchase and sale
involving shares of the same class of a portfolio of the Fund within any 120-day
period. For example, the following series of transactions would amount to
excessive trading: exchanging shares of Portfolio A for shares of Portfolio B,
then exchanging shares of Portfolio B for shares of Portfolio C and then
exchanging shares of Portfolio C for shares of Portfolio A within a 120-day
period. Two types of transactions are exempt from these excessive trading
restrictions: (i) trades exclusively between money market portfolios, and (ii)
trades made in connection with an asset allocation service managed or advised by
the Adviser and/or any of its affiliates.
 
INVESTMENT IN PORTFOLIOS BY OTHER INVESTMENT ACCOUNTS
 
    Morgan Stanley or its affiliates, including Morgan Stanley Asset Management
Inc., manage investment accounts for other clients, including other investment
companies, that invest in Class A or Class B shares of the portfolios. From time
to time, one or more of the portfolios used for investment by these accounts may
experience relatively large investments or redemptions due to investment
decisions made on behalf of these accounts. These transactions will affect the
portfolios, since portfolios that experience significant redemptions may have to
sell portfolio securities and portfolios that receive additional cash will have
to invest it in additional portfolio securities. It is impossible to predict the
overall impact of these transactions over time, however, there could be adverse
effects on portfolio management. These transactions also could have tax
consequences if sales of portfolio securities result in gains or could increase
transaction costs. The Adviser, representing the interests of the portfolios, is
committed to minimizing the impact of these transactions to the portfolios. The
Adviser, however, will have a conflict in fulfilling this responsibility in that
it also advises these investment accounts. The Adviser will monitor the impact
of these transactions on the portfolio.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of the Portfolio is
determined by dividing the total market value of the Portfolio's investments and
other assets attributable to such class, less any liabilities attributable to
such class, by the total number of outstanding shares of each class of the
Portfolio. Net asset value is calculated separately for each class of the
Portfolio. Net asset value per share is determined as of the close of the NYSE
(normally 4:00 p.m. Eastern Time) on each day that the NYSE is open for
business. Price information on listed securities is taken from the exchange
where the security is primarily traded. Securities listed on a U.S. securities
 
                                       26
<PAGE>
exchange for which market quotations are available are valued at the last quoted
sale price on the day the valuation is made. Securities listed on a foreign
exchange are valued at their closing price. Unlisted securities and listed
securities not traded on the valuation date and for which market quotations are
not readily available are valued at a price that is considered to best represent
fair value within a range not exceeding the current asked price nor less than
the current bid price. The current average bid and asked prices are determined
based on the bid and asked prices quoted on such valuation date by reputable
brokers.
 
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily. In addition, bonds and other fixed income securities may be
valued on the basis of prices provided by a pricing service when such prices are
believed to reflect the fair market value of such securities. The prices
provided by a pricing service are determined without regard to bid or last sale
prices, but take into account institutional size, trading in similar groups of
securities and any developments related to the specific securities. Securities
not priced in this manner are valued at the most recently quoted bid price or,
when securities exchange valuations are used, at the latest quoted sale price on
the day of valuation. If there is no such reported sale, the latest quoted bid
price will be used. Securities purchased with remaining maturities of 60 days or
less are valued at amortized cost, if it approximates market value. In the event
that amortized cost does not approximate market value, market prices as
determined above will be used.
 
    The value of other assets and securities for which quotations are not
readily available (including restricted and unlisted foreign securities) and
those securities for which it is inappropriate to determine prices in accordance
with the above-stated procedure are determined in good faith at fair value using
methods determined by the Board of Directors. For purposes of calculating net
asset value per share, all assets and liabilities initially expressed in foreign
currencies will be translated into U.S. dollars at the mean of the bid and asked
price of such currencies against the U.S. dollar last quoted by a major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distribution expense accrual differential among the classes. The
net asset value of Class B shares will generally be lower than the net asset
value of the Class A shares as a result of the distribution expense charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise total return for each class of the
Portfolio. THESE FIGURES ARE BASED ON HISTORICAL EARNINGS AND ARE NOT INTENDED
TO INDICATE FUTURE PERFORMANCE.
 
    The Portfolio may advertise "total return" which shows what an investment in
a class of the Portfolio would have earned over a specified period of time (such
as one, five or ten years), assuming that all distributions and dividends by the
Portfolio were reinvested in the same class on the reinvestment dates during the
period. Total return does not take into account any federal or state income
taxes that may be payable on dividends and distributions or on redemption. The
Fund may also include comparative performance information in advertising or
marketing the Portfolio's shares, including data from Lipper Analytical
Services, Inc., other industry publications, business periodicals, rating
services and market indices.
 
                                       27
<PAGE>
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains distributions for a class of shares
will be automatically reinvested in additional shares of such class at net asset
value, except when, upon written notice to the Fund or by checking off the
appropriate box in the Distribution Option Section on the Account Registration
Form, a shareholder elects to receive income dividends and capital gains
distributions in cash.
 
    The Portfolio expects to distribute substantially all of its taxable net
investment income in the form of annual dividends. Net realized capital gains,
if any, after reduction for any available tax loss carryforwards will also be
distributed annually.
 
    Undistributed net investment income is included in the Portfolio's net
assets for the purpose of calculating net asset value per share. Therefore, on
the "ex-dividend" date, the net asset value per share excludes the dividend
(i.e., is reduced by the per share amount of the dividend). Dividends paid
shortly after the purchase of shares by an investor, although in effect a return
of capital, are taxable to shareholders subject to income tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of the Portfolio will differ at times.
Expenses of the Portfolio allocated to a particular class of shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of the Portfolio or its shareholders.
Accordingly, shareholders are urged to consult their tax advisors regarding
specific questions as to federal, state and local income taxes.
 
    The Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other portfolios. The Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Internal Revenue Code of 1986, as amended
(the "Code"), so that the Portfolio will be relieved of federal income tax on
that part of its net investment income and net capital gain that is distributed
to shareholders.
 
    The Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, net short-term capital gain) to
shareholders. Dividends from the Portfolio's net investment income are taxable
to shareholders as ordinary income, whether received in cash or reinvested in
additional shares. Such dividends paid by the Portfolio will generally not
qualify for the dividends-received deduction for corporate shareholders. The
Portfolio will report annually to its shareholders the amount of dividend income
qualifying for such treatment.
 
                                       28
<PAGE>
    Distributions of net capital gain are taxable to shareholders as a 20% rate
gain distribution (taxed at a rate of 20%) or a 28% rate gain distribution
(taxed at a rate of 28%), depending upon the designation by the Portfolio (such
designation being dependent upon the holding period of the Portfolio in the
underlying asset generating the net capital gain), regardless of how long the
shareholder has held the Portfolio's shares. The Portfolio will send reports
annually to shareholders of the federal income tax status of all distributions
made during the preceding year.
 
    The Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gain over short-term and long-term capital
loss, including any available capital loss carryforwards) prior to the end of
each calendar year to avoid liability for federal excise tax.
 
    Dividends and other distributions declared by the Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders in that year if the distributions are paid by the Portfolio at
any time during the following January.
 
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any taxable dividends, capital gains distributions and redemption proceeds paid
to any individual or certain other non-corporate shareholder (i) who has failed
to provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Account Registration Form; (ii) who is subject to backup withholding by the
Internal Revenue Service; or (iii) who has not certified to the Fund that such
shareholder is not subject to backup withholding. This backup withholding is not
an additional tax, and any amounts withheld may be credited against the
shareholder's ultimate U.S. tax liability.
 
    The sale, exchange or redemption of shares will result in taxable gain or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the sale, exchange or redemption proceeds exceed or are
less than the shareholder's tax adjusted basis in the sold, exchanged or
redeemed shares. If capital gains distributions have been made with respect to
shares that are sold at a loss after being held for six months or less, then the
loss is treated as a long-term capital loss to the extent of the capital gains
distributions.
 
    Conversions of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisers concerning the
application of state and local income taxes to investments in the Portfolio,
which may differ from the federal income tax consequences described above.
 
    Investment income received by the Portfolio from sources within foreign
countries may be subject to foreign income taxes withheld at the source. To the
extent that the Portfolio is liable for foreign income taxes so withheld, the
Portfolio intends to operate so as to meet the requirements of the Code to pass
through to the shareholders credit for foreign income taxes paid. Although the
Portfolio intends to meet Code requirements to pass through credit for such
taxes, there can be no assurance that the Portfolio will be able to do so.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN THE PORTFOLIO.
 
                                       29
<PAGE>
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolio
for their clients.
 
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other remuneration paid to Morgan Stanley or other affiliates must be
fair and reasonable in comparison to those of other broker-dealers for
comparable transactions involving similar securities being purchased or sold
during a comparable time period.
 
PORTFOLIO TURNOVER
 
    The Portfolio generally does not invest for short-term trading purposes,
however, when circumstances warrant, the Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolio will not consider portfolio turnover rate a
limiting factor in making investment decisions consistent with their respective
objective and policies. Higher portfolio turnover (e.g., over 100%) necessarily
will cause the Portfolio to pay correspondingly increased brokerage and trading
costs. In addition to transaction costs, higher portfolio turnover may result in
the realization of capital gains. As discussed under "Taxes," to the extent net
short-term capital gains are realized, any distributions resulting from such
gains are considered ordinary income for federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 40 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of the
Portfolio are currently classified into two classes, the Class A shares and the
Class B shares.
 
    The shares of the Portfolio, when issued, will be fully paid, nonassessable,
fully transferable and redeemable at the option of the holder. The shares have
no preference as to conversion, exchange, dividends, retirement or other
features and have no pre-emptive rights. The shares of the Portfolio have
non-cumulative voting rights,
 
                                       30
<PAGE>
which means that the holders of more than 50% of the shares voting for the
election of Directors can elect 100% of the Directors if they choose to do so.
Persons or organizations owning 25% or more of the outstanding shares of a
portfolio may be presumed to "control" (as that term is defined in the 1940 Act)
that portfolio. Under Maryland law, the Fund is not required to hold an annual
meeting of its shareholders unless required to do so under the 1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual and semi-annual reports. The
financial statements appearing in annual reports are audited by independent
accountants. Monthly unaudited portfolio data is also available from the Fund
upon request.
 
    In addition, the Adviser or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
CUSTODIAN
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs subcustodians approved by the Board of Directors of the Fund
in accordance with regulations of the Commission for the purpose of providing
custodial services for such assets. MSTC may also hold certain domestic assets
for the Fund. For more information on the custodians, see "General Information
- -- Custody Arrangements" in the Statement of Additional Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits its annual financial statements.
 
FUND COUNSEL
 
    Morgan, Lewis & Bockius LLP acts as the Fund's legal counsel.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       31
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
          ACTIVE COUNTRY ALLOCATION PORTFOLIO
           P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                                           <C>
                                                                    If you need assistance in filling out this form for the
      ACCOUNT INFORMATION                                           Morgan Stanley Institutional Fund, Inc., please contact your
      Fill in where applicable                                      Morgan Stanley representative or call us toll free
                                                                    1-800-548-7786. Please print all items except signature, and
                                                                    mail to the Fund at the address above.
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
         TENANCY IN COMMON
         IS INDICATED)
</TABLE>
 
1.
                  First Name                  Initial                  Last Name
2.
                  First Name                  Initial                  Last Name
                  First Name                  Initial                  Last Name
 
<TABLE>
<C>   <S>                                       <C>
      3. CORPORATIONS,
         TRUSTS AND OTHERS
         Please call the Fund for additional
      documents that may be required to set up
      account and to authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                     <C>                 <C>                   <C>               <C>
Type of Registration:   / / INCORPORATED    / / UNINCORPORATED    / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                            ASSOCIATION                               (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
 
<TABLE>
<C>   <S>                                            <C>
  B)  MAILING ADDRESS
      Please fill in completely, including
      telephone number(s).
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
/ / Non-Resident Alien
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
 
<TABLE>
<C>   <S>                                            <C>                                  <C>
  C)  TAXPAYER                                       Enter your Taxpayer Identification Number. For most individual
      IDENTIFICATION                                 taxpayers, this is your Social Security Number.
      NUMBER
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
         TENANCY IN COMMON
         IS INDICATED)
      For Custodian account
      of a minor (Uniform
      Gifts/Transfers to Minor
      Acts), give the Social
      Security Number of
      the minor.
                                                                                          OR
                                                     1.         TAXPAYER IDENTIFICATION   SOCIAL SECURITY NUMBER
                                                     NUMBER ("TIN")                       ("SSN")
                                                                                          OR
                                                     2.         TIN                       SSN
                                                                                          OR
                                                     TIN                                  SSN
                                                     IMPORTANT TAX INFORMATION
                                                     You (as a payee) are required by law to provide us (as payer) with your
                                                     correct TIN(s) or SSN(s). Accounts that have a missing or incorrect
                                                     TIN(s) or SSN(s) will be subject to backup withholding at a 31% rate on
                                                     dividends, distributions and other payments. If you have not provided us
                                                     with your correct TIN(s) or SSN(s), you may be subject to a $50 penalty
                                                     imposed by the Internal Revenue Service.
                                                     Backup withholding is not an additional tax; the tax liability of
                                                     persons subject to backup withholding will be reduced by the amount of
                                                     tax withheld. If withholding results in an overpayment of taxes, a
                                                     refund may be obtained.
                                                     You may be notified that you are subject to backup withholding under
                                                     Section 3406(a)(1)(C) of the Internal Revenue Code because you have
                                                     underreported interest or dividends or you were required to, but failed
                                                     to, file a return which would have included a reportable interest or
                                                     dividend payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                        <C>                             <C>                   <C>
  D)  PORTFOLIO AND              For Purchase of the following
      CLASS SECTION              Portfolio:                      / / Class A Shares $  / / Class B Shares $
      (Class A shares minimum    Active Country Allocation
      $500,000 for the           Portfolio
      Portfolio and Class B
      shares minimum $100,000
      for the Portfolio).
      Please indicate class and
      amount.
                                                                 Total Initial Investment $
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate portfolio
      and manner of payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                                 <C>
/ / Exchange $ From                                                                           -- - - - - - - - - - -- - -
                                                      Name of Portfolio                               Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on                       -- - - - - - - - - - -- - -
                                                                                            Account No.               (Check
                                                                                      (Previously assigned by the Fund)     Digit)
                                                                            Date
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  F)  DISTRIBUTION               Income dividends and capital gains distributions (if any) to
      OPTION                     be reinvested in additional shares unless either box below
                                 is checked.
                                 / / Income dividends to be paid in cash, capital gains
                                 distributions (if any) in shares.
                                 / / Income dividends and capital gains distributions (if
                                 any) to be paid in cash.
</TABLE>
 
<TABLE>
<C>   <S>                             <C>                                       <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone         Name of COMMERCIAL Bank (Not Savings
      AND EXCHANGE                    requests to wire redemption proceeds to   Bank)
      OPTION                          the commercial bank indicated at right    Bank Account No.
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund
      wish to redeem or exchange      account is registered if such requests                                        Bank
      shares by telephone. A          are believed to be authentic.                                                  ABA
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent                                         No.
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated    Name(s) in which your Bank Account is
      YOUR FUND ACCOUNT.              by telephone are genuine. These           Established
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal      Bank's Street
      NOT BE HONORED UNLESS THE BOX   identification information at the time    Address
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by   City                   State                   Zip
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  H)  INTERESTED PARTY
      OPTION                                                                                      Name
      In addition to the
      account statement sent to
      my/our registered                                                                          Address
      address, I/we hereby
      authorize the Fund to      City         State         Zip Code
      mail duplicate statements
      to the name and address
      provided at right.
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  I)  DEALER
      INFORMATION
                                 Representative Name                        Representative
                                 No.                            Branch
                                 No.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                        <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here ,
</TABLE>
 
<TABLE>
<S>                                  <C>
The undersigned certify that I/we have full authority and legal capacity
to purchase and redeem shares of the Fund and affirm that I/we have
received a current Prospectus of the Morgan Stanley Institutional Fund,
Inc. and agree to be bound by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF
PERJURY THAT THE INFORMATION ON THIS APPLICATION IS COMPLETE AND CORRECT
AND THAT AS REQUIRED BY FEDERAL LAW (PLEASE CHECK APPLICABLE BOXES
BELOW):
/ / U.S. CITIZEN(S)/TAXPAYER(S):
       / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM
           IS/ARE THE CORRECT SSN(S) OR TIN(S) AND (2) I/WE ARE NOT
           SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE ARE
           EXEMPT FROM BACKUP WITHHOLDING; (B) I/WE HAVE NOT BEEN
           NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT I/WE
           ARE SUBJECT TO BACKUP WITHHOLDING AS A RESULT OF A FAILURE TO
           REPORT ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED
           ME/US THAT I AM/WE ARE NO LONGER SUBJECT TO BACKUP
           WITHHOLDING.
       / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE
           HAVE APPLIED, OR INTEND TO APPLY, TO THE IRS OR THE SOCIAL
           SECURITY ADMINISTRATION FOR A TIN OR A SSN AND I/WE
           UNDERSTAND THAT IF I/WE DO NOT PROVIDE EITHER NUMBER TO CHASE
           GLOBAL FUNDS SERVICES COMPANY ("CGFSC") WITHIN 60 DAYS OF THE
           DATE OF THIS APPLICATION OR IF I/WE FAIL TO FURNISH MY/OUR
           CORRECT SSN(S) OR TIN(S), I/WE MAY BE SUBJECT TO A PENALTY
           AND A 31% BACKUP WITHHOLDING ON DISTRIBUTIONS AND REDEMPTION
           PROCEEDS. (PLEASE PROVIDE EITHER NUMBER ON IRS FORM W-9). YOU
           MAY REQUEST SUCH FORM BY CALLING CGFSC AT 800-282-4404.
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S. CITIZENS
OR RESIDENTS AND I/WE ARE EXEMPT FOREIGN PERSONS AS DEFINED BY THE
INTERNAL REVENUE SERVICE.
 
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY
PROVISION OF THIS DOCUMENT OTHER THAN THE CERTIFICATIONS REQUIRED TO
AVOID BACKUP WITHHOLDING.
 
                                     (X)
(X)                                  Signature (if joint account, both
Signature                                                         Date must sign)         Date
</TABLE>
<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<S>                                                 <C>
                                                    PAGE
                                                    ----
Fund Expenses.....................................    2
Financial Highlights..............................    4
Prospectus Summary................................    6
Investment Objective and Policies.................   10
Additional Investment Information.................   11
Investment Limitations............................   18
Management of the Fund............................   18
Purchase of Shares................................   21
Redemption of Shares..............................   23
Account Policies and Services.....................   25
Valuation of Shares...............................   26
Performance Information...........................   27
Dividends and Capital Gains Distributions.........   28
Taxes.............................................   28
Portfolio Transactions............................   30
General Information...............................   30
Account Registration Form
</TABLE>
 
                      ACTIVE COUNTRY ALLOCATION PORTFOLIO
 
                               A PORTFOLIO OF THE
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
 
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  Incorporated
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                      P.O. BOX 2798, BOSTON, MA 02208-2798
 
- ---------------------------------------
- ---------------------------------------
- ---------------------------------------
- ---------------------------------------
<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
- --------------------------------------------------------------------------------
 
                            GLOBAL EQUITY PORTFOLIO
                         INTERNATIONAL EQUITY PORTFOLIO
                       INTERNATIONAL SMALL CAP PORTFOLIO
                           EUROPEAN EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
 
                                ----------------
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a series of diversified and non-diversified investment portfolios
("portfolios"). The Fund is designed to provide clients with attractive
alternatives for meeting their investment needs. The Fund currently consists of
thirty-two portfolios representing a broad range of investment choices. This
prospectus (the "Prospectus") pertains to the Class A and the Class B shares of
the Global Equity, International Equity, and European Equity Portfolios (each a
"Multiclass Portfolio" and collectively, the "Multiclass Portfolios") and to the
Class A Shares of the International Small Cap Portfolio (each, a "Portfolio" and
collectively, the "Portfolios"). The Class A shares currently offered by the
Portfolios and Class B shares currently offered by the Multiclass Portfolios
have different minimum investment requirements and fund expenses. Shares of the
Portfolios are offered with no sales charge, exchange fee or redemption fee,
(except that the International Small Cap Portfolio may impose a transaction
fee). The International Equity Portfolio is currently closed to new investors
with the exception of certain Morgan Stanley & Co. Incorporated ("Morgan
Stanley") customers, employees of Morgan Stanley, certain tax-qualified
retirement plans and other investment companies advised by Morgan Stanley Asset
Management Inc. and its affiliates.
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator"), and with Morgan Stanley as Distributor, the Fund makes
available to institutional and high net worth individual investors a series of
portfolios which benefit from the investment expertise and commitment to
excellence associated with Morgan Stanley and its affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under "Prospectus Summary" below. The Fund
currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging Markets,
European Equity, European Real Estate, Global Equity, International Equity,
International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) EQUITY AND FIXED INCOME -- Balanced
Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global
Fixed Income, High Yield and Municipal Bond Portfolios; and (v) MONEY MARKET --
Money Market and Municipal Money Market Portfolios. Additional information about
the Fund is contained in a "Statement of Additional Information," dated May 1,
1998, which is incorporated herein by reference. The Statement of Additional
Information and the prospectuses pertaining to the other portfolios of the Fund
are available upon request and without charge by writing or calling the Fund at
the address and telephone number set forth above.
 
 THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
   EXCHANGE COMMISSION, NOR HAS THE SECURITIES AND EXCHANGE COMMISSION
    PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY
       REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
                  THE DATE OF THIS PROSPECTUS IS MAY 1, 1998.
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates the expenses and fees that a shareholder of
each Portfolio listed below will incur.
 
<TABLE>
<CAPTION>
                                        GLOBAL EQUITY      INTERNATIONAL EQUITY    INTERNATIONAL SMALL      EUROPEAN EQUITY
SHAREHOLDER TRANSACTION EXPENSES          PORTFOLIO              PORTFOLIO            CAP PORTFOLIO            PORTFOLIO
- ----------------------------------  ---------------------  ---------------------  ---------------------  ---------------------
<S>                                 <C>                    <C>                    <C>                    <C>
Maximum Sales Load Imposed on
 Purchases
  Class A.........................             None                   None                   None*                  None
  Class B.........................             None                   None                    N/A                   None
Maximum Sales Load Imposed on
 Reinvested Dividends
  Class A.........................             None                   None                   None                   None
  Class B.........................             None                   None                    N/A                   None
Deferred Sales Load
  Class A.........................             None                   None                   None                   None
  Class B.........................             None                   None                    N/A                   None
Redemption Fees
  Class A.........................             None                   None                  1.00%*                  None
  Class B.........................             None                   None                    N/A                   None
Exchange Fees
  Class A.........................             None                   None                   None                   None
  Class B.........................             None                   None                    N/A                   None
</TABLE>
 
- --------------------------
* Shareholders of the International Small Cap Portfolio may be charged a 1.00%
  transaction fee, which is payable directly to the International Small Cap
  Portfolio, in connection with each purchase and redemption of shares of the
  Portfolio. The transaction fee is intended to allocate transaction costs
  associated with purchases and redemptions of shares of the Portfolio to
  investors actually making such purchases and redemptions rather than to the
  Portfolio's other shareholders. The 1.00% fee represents the Adviser's
  estimate of such transaction costs, which include the costs of acquiring and
  disposing of Portfolio securities. The transaction fee is not a sales charge
  or load, and is retained by the Portfolio. The fee does not apply to
  portfolios of the Fund other than the International Small Cap Portfolio and is
  not charged in connection with the reinvestment of dividends or capital gain
  distributions. The fee will not be charged with respect to purchases and
  redemptions that do not result in actual transaction costs to the Portfolio.
  Examples of such transactions include offsetting purchases and redemptions by
  different shareholders occurring at the same time and in-kind purchases and
  redemptions.
 
                                       2
<PAGE>
 
<TABLE>
<CAPTION>
ANNUAL FUND OPERATING EXPENSES                                            INTERNATIONAL
 (AS A PERCENTAGE OF AVERAGE NET                     GLOBAL EQUITY           EQUITY         INTERNATIONAL SMALL   EUROPEAN EQUITY
 ASSETS)                                               PORTFOLIO            PORTFOLIO          CAP PORTFOLIO         PORTFOLIO
- ------------------------------------------------  -------------------  -------------------  -------------------  ------------------
Management Fee (Net of Fee Waivers)**
<S>                                               <C>                  <C>                  <C>                  <C>
  Class A.......................................           0.69%                0.78%                0.88%                0.71%
  Class B.......................................           0.69%                0.78%                  N/A                0.71%
12b-1 Fees
  Class A.......................................            None                 None                 None                 None
  Class B.......................................           0.25%                0.25%                  N/A                0.25%
Other Expenses
  Class A.......................................           0.31%                0.22%                0.27%                0.29%
  Class B.......................................           0.31%                0.22%                  N/A                0.29%
                                                         -------              -------              -------           ----------
Total Operating Expenses (Net of Fee Waivers)**
  Class A.......................................           1.00%                1.00%                1.15%                1.00%
  Class B.......................................           1.25%                1.25%                  N/A                1.25%
                                                         -------              -------              -------           ----------
                                                         -------              -------              -------           ----------
</TABLE>
 
- --------------------------
 
 ** The Adviser has agreed to waive its management fees and/or reimburse the
    Portfolios, if necessary, if such fees would cause the total annual
    operating expenses of each of the Portfolios to exceed a specified
    percentage of its respective average daily net assets. As a result of these
    reductions, the Management Fees stated above are lower than the contractual
    fees stated under "Management of the Fund." The Adviser reserves the right
    to terminate any of its fee waivers and/or expense reimbursements at any
    time in its sole discretion. For further information on Fund expenses, see
    "Management of the Fund." Set forth below, for each Portfolio as applicable,
    are the management fees and total operating expenses absent such fee waivers
    and/or expense reimbursements as a percentage of average daily net assets of
    the Class A shares of the Portfolios and Class B Shares of the Multiclass
    Portfolios, respectively.
 
<TABLE>
<CAPTION>
                                                             TOTAL
                                                       OPERATING EXPENSES
                                          MANAGEMENT         ABSENT
                                             FEES         FEE WAIVERS
                                          ABSENT FEE   ------------------
PORTFOLIO                                  WAIVERS     CLASS A   CLASS B
- ----------------------------------------  ----------   -------   --------
<S>                                       <C>          <C>       <C>
Global Equity...........................    0.80%       1.11%     1.36%
International Equity....................    0.80%       1.02%     1.27%
International Small Cap.................    0.95%       1.22%      N/A
European Equity.........................    0.80%       1.09%     1.34%
</TABLE>
 
    The purpose of the table is to assist the investor in understanding the
various expenses that an investor in the Portfolios will bear directly or
indirectly. Expenses and fees are based on actual figures for the fiscal year
ended December 31, 1997. Due to the continuous nature of Rule 12b-1 fees,
long-term Class B shareholders may pay more than the equivalent of the maximum
front-end sales charges otherwise permitted by the National Association of
Securities Dealers, Inc. ("NASD") Conduct Rules.
 
                                       3
<PAGE>
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (i) a 5% annual rate of return, and (ii) redemption
at the end of each time period. As noted in the table above, the only fee
charged by the Fund upon purchase or redemption of Fund shares is the 1%
transaction fee that may be assessed on purchases and redemptions of shares of
the International Small Cap Portfolio, which charges are reflected in this
example. The following example is based on total operating expenses of the
Portfolios after fee waivers.
 
<TABLE>
<CAPTION>
                                     1 YEAR  3 YEARS   5 YEARS   10 YEARS
                                     ------  --------  --------  ---------
<S>                                  <C>     <C>       <C>       <C>
Global Equity Portfolio
  Class A..........................  $  10   $    32   $    55   $    122
  Class B..........................     13        40        69        151
International Equity Portfolio
  Class A..........................     10        32        55        122
  Class B..........................     13        40        69        151
International Small Cap Portfolio
  Class A..........................     32        58        85        163
European Equity Portfolio
  Class A..........................     10        32        55        122
  Class B..........................     13        40        69        151
</TABLE>
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. ACTUAL EXPENSES MAY BE GREATER OR LESS THAN THOSE
SHOWN.
 
                                       4
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following tables provide financial highlights for the Class A and Class
B shares of the Multiclass Portfolios and the Class A shares of the
International Small Cap Portfolio for each of the periods in the five years
ended December 31, 1997. The audited financial highlights for each Portfolio's
shares for each of the periods presented are part of the Fund's financial
statements which appear in the Fund's December 31, 1997 Annual Report to
Shareholders and which are incorporated by reference into the Fund's Statement
of Additional Information. Each Portfolio's financial highlights for each of the
periods presented have been audited by Price Waterhouse LLP, whose unqualified
report thereon is also incorporated by reference into the Statement of
Additional Information. Additional performance information is included in the
Annual Report. The Annual Report and the financial statements therein, along
with the Statement of Additional Information, are available at no cost from the
Fund at the address and telephone number noted on the cover page of this
Prospectus. After October 31, 1992, the Fund changed its fiscal year end to
December 31. The following information should be read in conjunction with
financial statements and notes thereto.
 
                                       5
<PAGE>
                            GLOBAL EQUITY PORTFOLIO
<TABLE>
<CAPTION>
                                                                   CLASS A
                                          ---------------------------------------------------------
                                                           YEAR ENDED DECEMBER 31,
                                          ---------------------------------------------------------
                                              1997           1996           1995           1994
                                          ------------   ------------   ------------   ------------
<S>                                       <C>            <C>            <C>            <C>
NET ASSET VALUE, BEGINNING OF PERIOD....    $ 16.24        $ 14.31        $ 13.40        $ 13.87
                                          ------------   ------------   ------------   ------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1).............       0.21           0.23           0.18           0.08
  Net Realized and Unrealized Gain on
   Investments..........................       3.61           3.02           2.26           0.79
                                          ------------   ------------   ------------   ------------
    Total from Investment Operations....       3.82           3.25           2.44           0.87
                                          ------------   ------------   ------------   ------------
DISTRIBUTIONS
  Net Investment Income.................      (0.40)         (0.23)         (0.22)         (0.12)
  In Excess of Net Investment Income....         --             --             --             --
  Net Realized Gain.....................      (1.14)         (1.09)         (1.31)         (1.22)
                                          ------------   ------------   ------------   ------------
    Total Distributions.................      (1.54)         (1.32)         (1.53)         (1.34)
                                          ------------   ------------   ------------   ------------
NET ASSET VALUE, END OF PERIOD..........    $ 18.52        $ 16.24        $ 14.31        $ 13.40
                                          ------------   ------------   ------------   ------------
                                          ------------   ------------   ------------   ------------
TOTAL RETURN............................      23.75%         22.83%         18.66%          6.95%
                                          ------------   ------------   ------------   ------------
                                          ------------   ------------   ------------   ------------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)..........................   $108,074        $80,297        $91,675        $78,935
  Ratio of Expenses to Average Net
   Assets (1)...........................       1.00%          1.00%          1.00%          1.00%
  Ratio of Net Investment Income to
   Average Net Assets (1)...............       1.07%          1.38%          1.17%          0.87%
  Portfolio Turnover Rate...............         30%            26%            28%            12%
  Average Commission Rate Per Share#....    $0.0312        $0.0299            N/A            N/A
- ----------------------------------
  Average Commission Rate as a
   Percentage of Trade Amount#..........       0.26%          0.25%           N/A            N/A
(1) Effect of voluntary expense
    limitation during the period:
     Per share benefit to net investment
      income............................      $0.02          $0.03          $0.02          $0.02
   Ratios before expense limitation:
     Expenses to Average Net Assets.....       1.11%          1.15%          1.13%          1.24%
     Net Investment Income to Average
      Net Assets........................       0.96%          1.23%          1.04%          0.63%
 
<CAPTION>
                                                           CLASS A
                                          ------------------------------------------
                                                                                                  CLASS B
                                                                                        ----------------------------
                                                                        PERIOD FROM                     PERIOD FROM
                                                          TWO MONTHS      JULY 15,                       JANUARY 2,
                                                            ENDED         1992* TO       YEAR ENDED      1996*** TO
                                                         DECEMBER 31,   OCTOBER 31,     DECEMBER 31,    DECEMBER 31,
                                              1993           1992           1992            1997            1996
                                          ------------   ------------   ------------    ------------    ------------
<S>                                       <C>            <C>            <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD....    $  9.75        $  9.35        $ 10.00          $16.21          $14.36
                                          ------------   ------------   ------------       ------          ------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1).............       0.08           0.01           0.02            0.16            0.13
  Net Realized and Unrealized Gain on
   Investments..........................       4.18           0.39          (0.67)           3.60            3.02
                                          ------------   ------------   ------------       ------          ------
    Total from Investment Operations....       4.26           0.40          (0.65)           3.76            3.15
                                          ------------   ------------   ------------       ------          ------
DISTRIBUTIONS
  Net Investment Income.................      (0.02)            --             --           (0.37)          (0.21)
  In Excess of Net Investment Income....      (0.03)            --             --              --              --
  Net Realized Gain.....................      (0.09)            --             --           (1.14)          (1.09)
                                          ------------   ------------   ------------       ------          ------
    Total Distributions.................      (0.14)            --             --           (1.51)          (1.30)
                                          ------------   ------------   ------------       ------          ------
NET ASSET VALUE, END OF PERIOD..........    $ 13.87        $  9.75        $  9.35          $18.46          $16.21
                                          ------------   ------------   ------------       ------          ------
                                          ------------   ------------   ------------       ------          ------
TOTAL RETURN............................      44.24%          4.28%         (6.50)%         23.37%          22.04%
                                          ------------   ------------   ------------       ------          ------
                                          ------------   ------------   ------------       ------          ------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)..........................    $19,918        $11,739        $11,257          $5,910          $3,928
  Ratio of Expenses to Average Net
   Assets (1)...........................       1.00%          1.00%**        1.00%**         1.25%           1.25%**
  Ratio of Net Investment Income to
   Average Net Assets (1)...............       0.84%          0.69%**        1.00%**         0.80%           1.29%**
  Portfolio Turnover Rate...............         42%             5%            10%             30%             26%
  Average Commission Rate Per Share#....        N/A            N/A            N/A         $0.0312         $0.0299
- ----------------------------------
  Average Commission Rate as a
   Percentage of Trade Amount#..........        N/A            N/A            N/A            0.26%           0.25%
(1) Effect of voluntary expense
    limitation during the period:
     Per share benefit to net investment
      income............................      $0.01          $0.02          $0.08           $0.02           $0.01
   Ratios before expense limitation:
     Expenses to Average Net Assets.....       1.66%          2.49%**        5.22%**         1.36%           1.39%**
     Net Investment Income to Average
      Net Assets........................       0.18%         (0.80)%**      (3.22)%**        0.69%           1.15%**
</TABLE>
 
- --------------------------------------------------------------------------------
 
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period.
 
                                       6
<PAGE>
                         INTERNATIONAL EQUITY PORTFOLIO
<TABLE>
<CAPTION>
                                                                        CLASS A
                                  ------------------------------------------------------------------------------------
                                                                                                              TWO
                                                                                                            MONTHS
                                                        YEAR ENDED DECEMBER 31,                              ENDED
                                  --------------------------------------------------------------------     DEC. 31,
                                     1997          1996          1995          1994           1993           1992
                                  -----------   -----------   -----------   -----------   ------------   -------------
<S>                               <C>           <C>           <C>           <C>           <C>            <C>
NET ASSET VALUE, BEGINNING OF
 PERIOD.......................     $    16.95    $    15.15    $    15.34    $    14.09     $   9.98       $   9.83
                                  -----------   -----------   -----------   -----------   ------------   -------------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Income (1)...           0.30          0.25          0.16          0.16         0.15           0.01
  Net Realized and Unrealized
   Gain on Investments........           2.01          2.71          1.55          1.54         4.36           0.14
                                  -----------   -----------   -----------   -----------   ------------   -------------
    Total from Investment
     Operations...............           2.31          2.96          1.71          1.70         4.51           0.15
                                  -----------   -----------   -----------   -----------   ------------   -------------
DISTRIBUTIONS
  Net Investment Income.......          (0.48)        (0.36)        (0.06)        (0.18)       (0.01)            --
  In Excess of Net Investment
   Income.....................             --            --            --            --        (0.13)            --
  Net Realized Gain...........          (1.62)        (0.80)        (1.84)        (0.27)       (0.26)            --
                                  -----------   -----------   -----------   -----------   ------------   -------------
    Total Distributions.......          (2.10)        (1.16)        (1.90)        (0.45)       (0.40)            --
                                  -----------   -----------   -----------   -----------   ------------   -------------
NET ASSET VALUE, END OF
 PERIOD.......................     $    17.16    $    16.95    $    15.15    $    15.34     $  14.09       $   9.98
                                  -----------   -----------   -----------   -----------   ------------   -------------
                                  -----------   -----------   -----------   -----------   ------------   -------------
TOTAL RETURN..................          13.91%        19.64%        11.77%        12.39%       46.50%          1.53%
                                  -----------   -----------   -----------   -----------   ------------   -------------
                                  -----------   -----------   -----------   -----------   ------------   -------------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)................     $2,822,900    $2,264,424    $1,598,530    $1,304,770     $947,045       $510,727
  Ratio of Expenses to Average
   Net Assets (1).............           1.00%         1.00%         1.00%         1.00%        1.00%          1.00%**
  Ratio of Net Investment
   Income to Average Net
   Assets (1).................           1.49%         1.64%         1.38%         1.12%        1.25%          0.68%**
  Portfolio Turnover Rate.....             33%           18%           27%           16%          23%             5%
  Average Commission Rate Per
   Share#.....................        $0.0201       $0.0238           N/A           N/A          N/A            N/A
- ----------------------------------------
  Average Commission Rate as a
   Percentage of Trade
   Amount#....................          0.21%          0.26%          N/A           N/A          N/A            N/A
(1) Effect of voluntary
    expense limitation during
    the period:
     Per share benefit to net
      investment income.......          $0.00+        $0.00        $0.003        $0.004        $0.01          $0.00
   Ratios before expense
    limitation:
     Expenses to Average Net
      Assets..................           1.02%         1.02%         1.03%         1.03%        1.06%          1.14%**
     Net Investment Income to
      Average Net Assets......           1.47%         1.61%         1.35%         1.09%        1.19%          0.54%**
 
<CAPTION>
                                                         CLASS A                                     CLASS B
                                  ------------------------------------------------------     -----------------------
                                                                                                           PERIOD
                                                                                                            FROM
                                                                                                           JAN. 2,
                                                                               AUG. 4*         YEAR        1996***
                                           YEAR ENDED OCTOBER 31,                TO            ENDED         TO
                                  ----------------------------------------     OCT. 31       DEC. 31,     DEC. 31,
                                     1992           1991          1990          1989           1997         1996
                                  -----------    -----------   -----------   -----------     ---------   -----------
<S>                             <C>              <C>           <C>           <C>             <C>         <C>
NET ASSET VALUE, BEGINNING OF
 PERIOD.......................      $  10.52       $   10.05     $    9.72     $  10.00       $ 16.93     $ 15.24
                                  -----------    -----------   -----------   -----------     ---------   -----------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Income (1)...          0.12            0.12          0.19         0.05          0.23        0.23
  Net Realized and Unrealized
   Gain on Investments........         (0.59)           0.58          0.20        (0.33)         2.02        2.59
                                  -----------    -----------   -----------   -----------     ---------   -----------
    Total from Investment
     Operations...............         (0.47)           0.70          0.39        (0.28)         2.25        2.82
                                  -----------    -----------   -----------   -----------     ---------   -----------
DISTRIBUTIONS
  Net Investment Income.......         (0.17)          (0.15)        (0.06)          --         (0.43)      (0.33)
  In Excess of Net Investment
   Income.....................            --              --            --           --            --          --
  Net Realized Gain...........         (0.05)          (0.08)           --           --         (1.62)      (0.80)
                                  -----------    -----------   -----------   -----------     ---------   -----------
    Total Distributions.......         (0.22)          (0.23)        (0.06)          --         (2.05)      (1.13)
                                  -----------    -----------   -----------   -----------     ---------   -----------
NET ASSET VALUE, END OF
 PERIOD.......................      $   9.83       $   10.52     $   10.05     $   9.72       $ 17.13     $ 16.93
                                  -----------    -----------   -----------   -----------     ---------   -----------
                                  -----------    -----------   -----------   -----------     ---------   -----------
TOTAL RETURN..................         (4.56)%          7.17%         3.99%        (2.8)%       13.57%      18.58%
                                  -----------    -----------   -----------   -----------     ---------   -----------
                                  -----------    -----------   -----------   -----------     ---------   -----------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)................      $486,836       $ 283,776     $ 110,716     $  7,811       $ 3,074     $ 5,393
  Ratio of Expenses to Average
   Net Assets (1).............          1.00%           1.00%         1.03%        1.35%**       1.25%       1.25%**
  Ratio of Net Investment
   Income to Average Net
   Assets (1).................          1.46%           2.27%         3.51%        2.34%**       1.21%       1.68%**
  Portfolio Turnover Rate.....            12%             22%           38%           0%           33%         18%
  Average Commission Rate Per
   Share#.....................           N/A             N/A           N/A          N/A       $0.0201     $0.0238
- ------------------------------
  Average Commission Rate as a
   Percentage of Trade
   Amount#....................           N/A             N/A           N/A          N/A          0.21%       0.26%
(1) Effect of voluntary
    expense limitation during
    the period:
     Per share benefit to net
      investment income.......         $0.00           $0.01           N/A        $0.01         $0.00+      $0.00
   Ratios before expense
    limitation:
     Expenses to Average Net
      Assets..................          1.02%           1.09%         1.24%        0.01%**       1.27%       1.27%**
     Net Investment Income to
      Average Net Assets......          1.44%           2.18%         3.30%            %**       1.19%       1.66%**
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period.
 
  + Amount is less than $0.01 per share.
 
                                       7
<PAGE>
                       INTERNATIONAL SMALL CAP PORTFOLIO
<TABLE>
<CAPTION>
                                                                         YEAR ENDED DECEMBER 31,
                                                              ---------------------------------------------
                                                                  1997            1996            1995
                                                              -------------   -------------   -------------
<S>                                                           <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD........................  $   16.83       $   14.94       $   15.15
                                                              -------------   -------------   -------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1).................................       0.25            0.21            0.24
  Net Realized and Unrealized Gain (Loss) on Investments....      (0.42)           2.29***         0.15***
                                                              -------------   -------------   -------------
    Total from Investment Operations........................      (0.17)           2.50            0.39
                                                              -------------   -------------   -------------
DISTRIBUTIONS
  Net Investment Income.....................................      (0.31)          (0.22)          (0.23)
  In Excess of Net Investment Income........................      (0.05)             --              --
  Net Realized Gain.........................................      (0.77)          (0.39)          (0.37)
                                                              -------------   -------------   -------------
    Total Distributions.....................................      (1.13)          (0.61)          (0.60)
                                                              -------------   -------------   -------------
TRANSACTION FEES............................................       0.08              --              --
NET ASSET VALUE, END OF PERIOD                                $   15.61       $   16.83       $   14.94
                                                              -------------   -------------   -------------
                                                              -------------   -------------   -------------
TOTAL RETURN................................................      (0.55)%         16.82%           2.60%
                                                              -------------   -------------   -------------
                                                              -------------   -------------   -------------
RATIO AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands).....................  $ 230,095       $ 234,743       $ 198,669
  Ratio of Expenses to Average Net Assets (1)...............       1.15%           1.15%           1.15%
  Ratio of Net Investment Income to
   Average Net Assets (1)...................................       1.37%           1.29%           1.72%
  Portfolio Turnover Rate...................................         39%             35%             24%
  Average Commission Rate Per Share#........................    $0.0134         $0.0159             N/A
- ------------------------------
  Average Commission Rate as a Percentage of Trade
   Amount#..................................................      0.31%           0.30%             N/A
(1) Effect of voluntary expense limitation during the
    period:
     Per share benefit to net investment income.............      $0.01           $0.01           $0.01
   Ratios before expense limitation:
     Expenses to Average Net Assets.........................       1.22%           1.23%           1.24%
     Net Investment Income(Loss) to Average Net Assets......       1.30%           1.20%           1.63%
 
<CAPTION>
 
                                                                                               PERIOD FROM
                                                                                              DECEMBER 15,
                                                                                                1992* TO
                                                                                              DECEMBER 31,
                                                                  1994           1993++           1992
                                                              -------------   -------------   -------------
<S>                                                           <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD........................  $   14.64       $   10.09       $   10.00
                                                              -------------   -------------      ------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1).................................       0.14            0.09            0.01
  Net Realized and Unrealized Gain (Loss) on Investments....       0.62***         4.48***         0.08***
                                                              -------------   -------------      ------
    Total from Investment Operations........................       0.76            4.57            0.09
                                                              -------------   -------------      ------
DISTRIBUTIONS
  Net Investment Income.....................................      (0.03)           0.00              --
  In Excess of Net Investment Income........................         --           (0.02)             --
  Net Realized Gain.........................................      (0.22)             --              --
                                                              -------------   -------------      ------
    Total Distributions.....................................      (0.25)          (0.02)             --
                                                              -------------   -------------      ------
TRANSACTION FEES............................................         --              --              --
NET ASSET VALUE, END OF PERIOD                                $   15.15       $   14.64       $   10.09
                                                              -------------   -------------      ------
                                                              -------------   -------------      ------
TOTAL RETURN................................................       5.25%          45.34%           0.90%
                                                              -------------   -------------      ------
                                                              -------------   -------------      ------
RATIO AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands).....................  $ 160,101       $  52,834       $   3,824
  Ratio of Expenses to Average Net Assets (1)...............       1.15%           1.15%           1.15%**
  Ratio of Net Investment Income to
   Average Net Assets (1)...................................       1.18%           0.66%           1.37%**
  Portfolio Turnover Rate...................................          8%             14%              0%
  Average Commission Rate Per Share#........................        N/A             N/A             N/A
- ------------------------------
  Average Commission Rate as a Percentage of Trade
   Amount#..................................................        N/A             N/A             N/A
(1) Effect of voluntary expense limitation during the
    period:
     Per share benefit to net investment income.............      $0.02           $0.10           $0.16
   Ratios before expense limitation:
     Expenses to Average Net Assets.........................       1.29%           1.86%          21.67%**
     Net Investment Income(Loss) to Average Net Assets......       1.04%          (0.05)%        (19.15)%**
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 
 ** Annualized
 
*** Reflects a 1% transaction fee on purchases and redemptions of capital
    shares.
 
 ++ Per share amounts for the year ended December 31, 1993 are based on average
    outstanding shares.
 
  # Beginning with fiscal year 1996, the Portfolio is required to disclose the
    average commission rate per share it paid for portfolio trades, on which
    commissions were charged, during the period.
 
                                       8
<PAGE>
                           EUROPEAN EQUITY PORTFOLIO
<TABLE>
<CAPTION>
                                                                                  CLASS A
                                               -----------------------------------------------------------------------------
                                                                                                                PERIOD FROM
                                                                                                                 APRIL 2,
                                                                  YEAR ENDED DECEMBER 31,                        1993* TO
                                               -------------------------------------------------------------   DECEMBER 31,
                                                   1997            1996            1995            1994            1993
                                               -------------   -------------   -------------   -------------   -------------
<S>                                            <C>             <C>             <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........  $   16.70       $   13.92       $   13.94       $   12.91       $   10.00
                                               -------------   -------------   -------------   -------------   -------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)..................       0.39            0.24            0.14            0.08            0.08
  Net Realized and Unrealized Gain on
   Investments...............................       2.58            2.85            1.37            1.29            2.83
                                               -------------   -------------   -------------   -------------   -------------
    Total from Investment Operations.........       2.97            3.09            1.51            1.37            2.91
                                               -------------   -------------   -------------   -------------   -------------
DISTRIBUTIONS
  Net Investment Income......................      (0.37)          (0.25)          (0.15)          (0.09)             --
  In Excess of Net Investment Income.........         --           (0.02)             --              --              --
  Net Realized Gain..........................      (1.34)          (0.04)          (1.38)          (0.25)             --
                                               -------------   -------------   -------------   -------------   -------------
    Total Distributions......................      (1.71)          (0.31)          (1.53)          (0.34)             --
                                               -------------   -------------   -------------   -------------   -------------
NET ASSET VALUE, END OF PERIOD...............  $   17.96       $   16.70       $   13.92       $   13.94       $   12.91
                                               -------------   -------------   -------------   -------------   -------------
                                               -------------   -------------   -------------   -------------   -------------
TOTAL RETURN.................................      17.88%          22.29%          11.85%          10.88%          29.10%
                                               -------------   -------------   -------------   -------------   -------------
                                               -------------   -------------   -------------   -------------   -------------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)......  $ 242,868       $ 178,356       $  69,583       $  27,634       $  12,681
  Ratio of Expenses to Average Net Assets
   (1).......................................       1.00%           1.00%           1.00%           1.00%           1.00%**
  Ratio of Net Investment Income to Average
   Net Assets (1)............................       1.96%           1.83%           1.37%           0.87%           1.23%**
  Portfolio Turnover Rate....................         43%             24%             13%             79%             15%
  Average Commission Rate Per Share#.........    $0.0207         $0.0212             N/A             N/A             N/A
- ----------------------------------
  Average Commission Rate as a Percentage of
   Trade Amount#.............................        0.20%          0.23%            N/A             N/A             N/A
(1) Effect of voluntary expense limitation
    during the period:
     Per share benefit to net investment
      income.................................      $0.02           $0.02           $0.03           $0.06           $0.09
   Ratios before expense limitation:
     Expenses to Average Net Assets..........       1.09%           1.16%           1.25%           1.62%           2.43%**
     Net Investment Income (Loss) to Average
      Net Assets.............................       1.87%           1.67%           1.12%           0.25%          (0.21)%**
 
<CAPTION>
 
                                                          CLASS B
                                               -----------------------------
                                                                PERIOD FROM
                                                                JANUARY 2,
                                                YEAR ENDED      1996*** TO
                                               DECEMBER 31,    DECEMBER 31,
                                                   1997            1996
                                               -------------   -------------
<S>                                            <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........  $   16.67       $   14.05
                                                  ------          ------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)..................       0.28            0.18
  Net Realized and Unrealized Gain on
   Investments...............................       2.66            2.73
                                                  ------          ------
    Total from Investment Operations.........       2.94            2.91
                                                  ------          ------
DISTRIBUTIONS
  Net Investment Income......................      (0.33)          (0.23)
  In Excess of Net Investment Income.........         --           (0.02)
  Net Realized Gain..........................      (1.34)          (0.04)
                                                  ------          ------
    Total Distributions......................      (1.67)          (0.29)
                                                  ------          ------
NET ASSET VALUE, END OF PERIOD...............  $   17.94       $   16.67
                                                  ------          ------
                                                  ------          ------
TOTAL RETURN.................................      17.73%          20.76%
                                                  ------          ------
                                                  ------          ------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)......  $   4,654          $2,654
  Ratio of Expenses to Average Net Assets
   (1).......................................       1.25%           1.25%**
  Ratio of Net Investment Income to Average
   Net Assets (1)............................       1.55%           1.67%**
  Portfolio Turnover Rate....................         43%             24%
  Average Commission Rate Per Share#.........    $0.0207         $0.0212
- ----------------------------------
  Average Commission Rate as a Percentage of
   Trade Amount#.............................       0.20%           0.23%
(1) Effect of voluntary expense limitation
    during the period:
     Per share benefit to net investment
      income.................................      $0.02           $0.02
   Ratios before expense limitation:
     Expenses to Average Net Assets..........       1.34%           1.40%**
     Net Investment Income (Loss) to Average
      Net Assets.............................       1.46%           1.52%**
</TABLE>
 
- --------------------------------------------------------------------------------
 
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
  # Beginning with fiscal year 1996, the Portfolio is required to disclose the
    average commission rate per share it paid for portfolio trades, on which
    commissions were charged, during the period.
 
                                       9
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and high net worth individual investors a broad range of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates providing customized services as Adviser, Administrator and
Distributor. Each portfolio offers Class A shares and Class B shares except the
International Small Cap and Municipal Money Market Portfolios which offer only
Class A shares. Each portfolio has its own investment objective and policies
designed to meet its specific goals. The investment objective of each Portfolio
described in this Prospectus is as follows:
 
    - The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of issuers throughout the world,
      including U.S. issuers.
 
    - The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of non-U.S. issuers.
 
    - The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
      by investing primarily in equity securities of non-U.S. issuers with
      equity market capitalizations of less than $1 billion.
 
    - The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of European issuers.
 
    The other portfolios of the Fund are described in other prospectuses which
may be obtained from the Fund at the address and phone number noted on the cover
page of this Prospectus. The investment objectives of these other portfolios are
listed below:
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    - The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
      appreciation by investing in accordance with country weightings determined
      by the Adviser in equity securities of non-U.S. issuers which, in the
      aggregate, replicate broad country indices.
 
    - The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of Asian issuers.
 
    - The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
      appreciation by investing primarily in equity securities of companies in
      the Asian real estate industry.
 
    - The CHINA GROWTH PORTFOLIO seeks to provide long-term capital appreciation
      by investing primarily in equity securities of issuers in The People's
      Republic of China, Hong Kong and Taiwan.
 
    - The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of emerging country issuers.
 
    - The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income and
      long-term capital appreciation by investing primarily in equity securities
      of companies in the European real estate industry.
 
    - The GOLD PORTFOLIO seeks long-term capital appreciation by investing
      primarily in equity securities of foreign and domestic issuers engaged in
      gold-related activities.
 
    - The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of non-U.S. issuers domiciled in
      EAFE countries.
 
                                       10
<PAGE>
    - The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of Japanese issuers.
 
    - The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of Latin American issuers and,
      from time to time, debt securities issued or guaranteed by Latin American
      governments or governmental entities.
 
    U.S. EQUITY:
 
    - The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by investing
      primarily in corporate equity and equity-linked securities.
 
    - The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation by
      investing primarily in growth-oriented equity securities of small- to
      medium-sized corporations.
 
    - The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
      investing in growth-oriented equity securities of medium and large
      capitalization companies.
 
    - The MICROCAP PORTFOLIO seeks long-term capital appreciation by investing
      primarily in growth-oriented equity securities of small corporations.
 
    - The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total return by
      investing in equity securities of small- to medium-sized companies which
      the Adviser believes to be undervalued.
 
    - The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by investing
      primarily in equity securities of companies that, in the opinion of the
      Adviser, are expected to benefit from their involvement in technology and
      technology-related industries.
 
    - The U.S. EQUITY PLUS PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of issuers included in the S&P
      500 Index ("S&P 500").
 
    - The U.S. REAL ESTATE PORTFOLIO seeks to provide above-average current
      income and long-term capital appreciation by investing primarily in equity
      securities of companies in the U.S. real estate industry, including
      substantial investment in real estate investment trusts.
 
    - The VALUE EQUITY PORTFOLIO seeks high total return by investing in equity
      securities which the Adviser believes to be undervalued relative to the
      stock market in general at the time of purchase.
 
    EQUITY AND FIXED INCOME:
 
    - The BALANCED PORTFOLIO seeks high total return while preserving capital by
      investing in a combination of equity securities which the Adviser believes
      to be undervalued and fixed income securities.
 
    FIXED INCOME:
 
    - The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by investing
      primarily in debt securities of government, government-related and
      corporate issuers located in emerging countries.
 
    - The FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
      with the preservation of capital by investing in a diversified portfolio
      of fixed income securities.
 
    - The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
      of return while preserving capital by investing in fixed income securities
      of issuers throughout the world, including U.S. issuers.
 
                                       11
<PAGE>
    - The HIGH YIELD PORTFOLIO seeks to maximize total return by investing in a
      diversified portfolio of high yield fixed income securities that offer a
      yield above that generally available on debt securities in the four
      highest rating categories of the recognized rating services.
 
    - The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a level
      of current income as is consistent with the preservation of capital by
      investing primarily in a variety of investment grade mortgage-backed
      securities.
 
    - The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of current
      income consistent with preservation of principal by investing in municipal
      obligations, the interest on which is exempt from federal income tax.
 
    MONEY MARKET:
 
    - The MONEY MARKET PORTFOLIO seeks to maximize current income and preserve
      capital while maintaining high levels of liquidity through investing in
      high-quality money market instruments with remaining maturities of one
      year or less.
 
    - The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current tax-exempt
      income and preserve capital while maintaining high levels of liquidity
      through investing in high-quality money market instruments with remaining
      maturities of one year or less which are exempt from federal income tax.
 
      THE CHINA GROWTH, GOLD, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS
      ARE CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley Dean Witter & Co., acts as investment adviser to the Fund and each of
its portfolios. As of March 31, 1998, Morgan Stanley Asset Management Inc. and
its affiliated institutional asset management companies managed assets of
approximately $166 billion, including assets under fiduciary advice. See
"Management of the Fund -- Investment Adviser" and "Management of the Fund --
Administrator."
 
HOW TO INVEST
 
    Class A shares of each Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of each
Multiclass Portfolio are offered at net asset value with no sales commission,
but with a 12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25%
of the Class B shares' average daily net assets on an annualized basis.
Shareholders of the International Small Cap Portfolio may be charged a 1.00%
transaction fee, which is payable directly to the International Small Cap
Portfolio, in connection with each purchase and redemption of shares of the
Portfolio. The minimum initial investment, generally, is $500,000 for Class A
shares of each Portfolio and $100,000 for Class B shares of each Multiclass
Portfolio. The minimum initial investment amount is reduced for certain
categories of investors. For additional information on how to purchase shares
and minimum initial investments, see "Purchase of Shares."
 
                                       12
<PAGE>
HOW TO REDEEM
 
    Class A shares or Class B shares of each Portfolio may be redeemed at any
time, without cost, at the net asset value per share of the applicable class
next determined after receipt of the redemption request, (except that
shareholders of the International Small Cap Portfolio may be charged a 1.00%
transaction fee, which is payable directly to the International Small Cap
Portfolio, in connection with each purchase and redemption of shares of the
Portfolio). The redemption price may be more or less than the purchase price.
Certain redemptions that cause the value of an account to remain for a
continuous 60-day period below the minimum investment amount for Class A shares
or for Class B shares may result in involuntary redemption or automatic
conversion. For additional information on how to redeem shares and involuntary
redemption or conversion, see "Purchase of Shares" and "Redemption of Shares."
 
RISK FACTORS
 
    Investing in each of the Portfolios entails certain risks and considerations
of which an investor should be aware. The Portfolios' share prices and
investment returns fluctuate and, when redeemed, an investment in the Portfolios
may be worth more or less than its original cost. The investment policies of the
Portfolios may entail the following risk factors:
 
    - EQUITY SECURITIES. Each Portfolio may invest in equity securities. Prices
      of equity securities fluctuate in response to many factors, including the
      financial health of the issuer and changes in economic and market
      conditions.
 
    - FOREIGN INVESTMENT. Each Portfolio may invest in the securities of foreign
      issuers. The risks of foreign investment include fluctuations in foreign
      currency values, political events affecting the country of issuance and
      potentially greater market volatility and lower liquidity.
 
    - EMERGING MARKET COUNTRY SECURITIES. Each Portfolio may invest in emerging
      market country securities which entail risks typically associated with
      investment in more established foreign markets. However, these risks may
      be intensified due to higher volatility and less liquidity of emerging
      markets, possible political risks associated with the country of issuance
      and generally weaker financial condition of issuers in these markets.
 
For additional information about risk factors, see also "Investment Objectives
and Policies" and "Additional Investment Information."
 
                                       13
<PAGE>
                       INVESTMENT OBJECTIVES AND POLICIES
 
    The investment objective of each Portfolio is described below, together with
the policies each Portfolio will employ in its efforts to achieve its objective.
Each Portfolio's investment objective is a fundamental policy which may not be
changed without the approval of a majority of the Portfolio's outstanding voting
securities. There is no assurance that the Portfolios will attain their
objectives. Each of the Portfolios invests in equity securities, which include
common and preferred stocks, convertible securities and rights and warrants to
purchase common stocks. In addition to the investments and strategies described
below, the Portfolios may invest in certain securities and obligations as set
forth in "Additional Investment Information." The investment policies described
below are not fundamental policies unless otherwise noted and may be changed
without shareholder approval.
 
THE GLOBAL EQUITY PORTFOLIO
 
    The Global Equity Portfolio seeks long-term capital appreciation by
investing primarily in equity securities of issuers throughout the world,
including U.S. issuers. At least 65% of the total assets of the Portfolio will
be invested in equity securities under normal circumstances. Under normal
circumstances, the Adviser expects that at least 20% of the Portfolio's total
assets will be invested in the common stocks of U.S. issuers. The remainder of
the Portfolio will be invested in issuers located throughout the world,
including those located in emerging markets. Although the Portfolio intends to
invest primarily in securities listed on stock exchanges, it will also invest in
securities traded in over-the-counter markets and may invest in equity
securities in the form of Depositary Receipts.
 
    The Adviser's approach in selecting investments for the Portfolio is
oriented to individual stock selection, and is value driven. In selecting stocks
for the Portfolio, the Adviser initially identifies those stocks which it
believes to be undervalued in relation to the issuer's assets, cash flow,
earnings and revenues, and then evaluates the future value of such stocks by
running the results of an in-depth study of the issuer through a dividend
discount model. The Adviser utilizes the research of a number of sources,
including Morgan Stanley Capital International, an affiliate of the Adviser
located in Geneva, Switzerland, in identifying attractive securities, and
applies a number of proprietary screening criteria to identify those securities
it believes to be undervalued. Portfolio holdings are regularly reviewed and
subjected to fundamental analysis to determine whether they continue to conform
to the Adviser's value criteria. Securities which no longer conform to such
value criteria are sold.
 
THE INTERNATIONAL EQUITY PORTFOLIO
 
    The investment objective of the International Equity Portfolio is to provide
long-term capital appreciation. The production of any current income is
incidental to this objective. The Portfolio seeks to achieve its objective by
investing primarily in equity securities of non-U.S. issuers. At least 65% of
the total assets of the Portfolio will be invested in such equity securities
under normal circumstances.
 
    The Adviser's orientation to individual stock selection and value driven
approach in selecting investments for the Portfolio are the same as those
described for the Global Equity Portfolio discussed above. While the Portfolio
is not subject to any specific geographic diversification requirements, it
currently intends to diversify investments among countries to reduce risk,
including currency risk. Investments will be made primarily in equity securities
of companies domiciled in developed countries, but may also be made in equity
securities of
 
                                       14
<PAGE>
issuers domiciled in emerging markets. Under normal circumstances, the Portfolio
will not invest in equity securities of U.S. issuers. Although the Portfolio
intends to invest primarily in equity securities listed on stock exchanges, it
will also invest in equity securities traded in over-the-counter markets.
 
THE INTERNATIONAL SMALL CAP PORTFOLIO
 
    The investment objective of the International Small Cap Portfolio is to
provide long-term capital appreciation. The production of any current income is
incidental to this objective. The Portfolio seeks to achieve its objective by
investing primarily in equity securities of non-U.S. issuers with equity market
capitalizations of less than $1 billion. The Portfolio will not, under normal
circumstances, invest in equity securities of U.S. issuers. At least 65% of the
total assets of the Portfolio will be invested in such equity securities under
normal circumstances. The Portfolio will invest a minimum of 80% of its total
assets in companies with market capitalizations of less than $1 billion. The
Adviser's orientation to individual stock selection and value driven approach in
selecting investments for the Portfolio are the same as those described for the
Global Equity Portfolio discussed above.
 
    While the Portfolio is not subject to any specific geographic
diversification requirements, it currently intends to diversify investments
among countries to reduce risk, including currency risk. Investments will be
made primarily in equity securities of companies domiciled in developed
countries. Limited investments may also be made in the securities of companies
domiciled in emerging countries, but will not normally exceed 5% of the total
assets of the Portfolio. Although the Portfolio intends to invest primarily in
equity securities listed on stock exchanges, it may also invest in equity
securities traded in over-the-counter markets and in privately placed
securities. Small capitalization securities involve greater issuer risk and the
markets for such securities may be more volatile and less liquid.
 
THE EUROPEAN EQUITY PORTFOLIO
 
    The investment objective of the European Equity Portfolio is to provide
long-term capital appreciation. The Portfolio seeks to achieve this objective by
investing primarily in equity securities of European issuers, including those
located in Germany, France, Switzerland, Belgium, Italy, Finland, Sweden,
Denmark, Norway and the United Kingdom. Investments may also be made in equity
securities of issuers located in the smaller and emerging markets of Europe.
 
    While the Portfolio is not subject to any specific geographic
diversification requirements, it currently intends to diversify investments
among countries to reduce currency risk. At least 65% of the total assets of the
Portfolio will be invested in equity securities of European issuers under normal
circumstances. The Portfolio will not, under normal circumstances, invest in
equity securities of U.S. issuers. The Adviser's orientation to individual stock
selection and value-driven approach in selecting investments for the Portfolio
are the same as those described for the Global Equity Portfolio discussed above.
Although the Portfolio intends to invest primarily in equity securities listed
on stock exchanges, it will also invest in equity securities traded in over-the-
counter markets.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    DEPOSITARY RECEIPTS.  The Global Equity Portfolio may invest in Depositary
Receipts, including American Depositary Receipts ("ADRs"), Global Depositary
Receipts ("GDRs"), European Depositary Receipts ("EDRs") and other Depositary
Receipts (which, together with ADRs, GDRs and EDRs, are hereinafter
 
                                       15
<PAGE>
collectively referred to as "Depositary Receipts"), to the extent that such
Depositary Receipts are or become available. ADRs are securities, typically
issued by a U.S. financial institution (a "depositary"), that evidence ownership
interests in a security or a pool of securities issued by a foreign issuer (the
"underlying issuer") and deposited with the depositary. ADRs may be "sponsored"
or "unsponsored." Sponsored ADRs are established jointly by a depositary and the
underlying issuer, whereas unsponsored ADRs may be established by a depositary
without participation by the underlying issuer. The issuers of the stock of
unsponsored ADRs are not obligated to disclose material information in the
United States and therefore, there may not be a correlation between such
information and the market value of the ADR. GDRs, EDRs and other types of
Depositary Receipts are typically issued by foreign depositaries, although they
may also be issued by U.S. depositaries, and evidence ownership interests in a
security or pool of securities issued by either a foreign or a U.S. corporation.
Generally, Depositary Receipts in registered form are designed for use in the
U.S. securities market and Depositary Receipts in bearer form are designed for
use in securities markets outside the United States. The Portfolio may invest in
sponsored and unsponsored Depositary Receipts. For purposes of the Portfolio's
investment policies, the Portfolio's investments in Depositary Receipts will be
deemed to be investments in the underlying securities.
 
    FOREIGN CURRENCY FORWARD CONTRACTS.  Each Portfolio may enter into foreign
currency forward contracts ("forward contracts") that provide for the purchase
or sale of an amount of a specified currency at a future date. The Portfolios
may use such contracts to protect against a decline in a foreign currency
against the U.S. dollar between the trade date and settlement date when the
Portfolio purchases or sells securities, lock in the U.S. dollar value of
dividends and interest on securities held by the Portfolio, and generally to
protect the U.S. dollar value of securities held by the Portfolio against
exchange rate fluctuation. While forward contracts may limit losses as a result
of exchange rate fluctuations, they will also limit any gains that might
otherwise have been realized. The Portfolio's Custodian may be required to place
cash or liquid securities in a segregated account in an amount equal to the
value of the Portfolio's total assets committed to the consummation of forward
contracts. If the value of the securities placed in the segregated account
declines, additional cash or securities will be placed in the account on a daily
basis so that the value of the account will be at least equal to the amount of
the Portfolio's commitments with respect to such contracts.
 
    FOREIGN INVESTMENT.  Each Portfolio may invest in the securities of foreign
issuers. Investment in securities of foreign issuers involves investment risks
somewhat different from those affecting securities of U.S. issuers. The
Portfolio's investments will be subject to political and economic events that
affect the countries in which it invests. Foreign issuers may be subject to
different accounting, auditing and financial standards and requirements. There
also may be less government supervision and regulation of foreign securities
exchanges, brokers and listed companies than in the United States. Many foreign
securities markets have substantially less trading volume than U.S. national
securities exchanges and, therefore, securities of some foreign issuers are less
liquid and more volatile than securities of comparable U.S. issuers. Brokerage
commissions and other transaction costs on foreign securities exchanges are
generally higher than in the United States. Dividends and interest paid by
foreign issuers may be subject to withholding and other foreign taxes, which may
decrease the net return on foreign investments as compared to dividends and
interest paid to the Portfolios by domestic companies. Investments in securities
of foreign issuers are generally denominated in foreign currencies and, since a
Portfolio may temporarily hold uninvested reserves in bank deposits in foreign
currencies, the value of a
 
                                       16
<PAGE>
Portfolio's assets as measured in U.S. dollars may be affected favorably or
unfavorably by changes in currency exchange rates and exchange control
regulations, and a Portfolio may incur costs in connection with conversions
between various currencies.
 
    The Portfolios may also invest in emerging market country securities.
Investing in emerging markets entails the risks associated with foreign
investment described above, however, these risks may be intensified in emerging
markets. Emerging markets can include every nation in the world except the
United States, Canada, Japan, Australia, New Zealand and most nations located in
Western Europe. Certain emerging market countries have historically experienced,
and may continue to experience, high rates of inflation, high interest rates,
exchange rate fluctuations, large amounts of external debt, trade difficulties
and unemployment. Further, the economies of developing countries generally are
heavily dependent upon international trade and, accordingly, have been, and may
continue to be, adversely affected by trade barriers, exchange controls and
other protectionist measures imposed or negotiated by the countries in which
they trade. There also are risks associated with the possibility of
nationalization, expropriation or confiscatory taxation, political changes,
government regulation, social instability or diplomatic developments (including
war) that could adversely affect the economies of such countries or the value of
a Portfolio's investments in those countries.
 
    LOANS OF PORTFOLIO SECURITIES.  Each Portfolio may lend its securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing net investment income. These loans must be secured
continuously by cash or equivalent collateral or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be risks of delay in recovery of the securities or even loss
of rights in the collateral should the borrower of the securities fail
financially. A Portfolio will not enter into securities loan transactions
exceeding in the aggregate 33 1/3% of the market value of the Portfolio's total
assets.
 
    MONEY MARKET INSTRUMENTS.  The Portfolios are permitted to invest in money
market instruments, although each Portfolio intends to stay invested in
securities satisfying its primary investment objective to the extent practical.
Consistent with their investment policies, each Portfolio may make money market
investments pending other investment or settlement for liquidity. In addition,
the Portfolios may invest in money market instruments for temporary defensive
purposes during adverse market conditions. The money market investments
permitted for the Portfolios include: obligations of the U.S. Government and its
agencies and instrumentalities, obligations of foreign sovereignties, commercial
paper, bank obligations (including certificates of deposit), other debt
securities and repurchase agreements.
 
    NON-PUBLICLY TRADED SECURITIES, PRIVATE PLACEMENTS AND RESTRICTED
SECURITIES.  The International Small Cap Portfolio may invest in securities that
are neither listed on a stock exchange nor traded over-the-counter, including
privately placed securities. Such unlisted equity securities may involve a
higher degree of business and financial risk that can result in substantial
losses. As a result of the absence of a public trading market for these
securities, they may be less liquid than publicly traded securities. Although
these securities may be resold in privately negotiated transactions, the prices
realized from these sales could be less than those originally paid by the
Portfolio or less than what may be considered the fair value of such securities.
Further, companies whose securities are not publicly traded may not be subject
to the disclosure and other investor protection requirements which might be
applicable if their securities were publicly traded. If such securities are
required to be registered under the securities laws of one or more jurisdictions
before being resold, the Portfolio may be required to bear the expenses of
registration.
 
                                       17
<PAGE>
    As a general matter, the Portfolio may not invest more than 15% of its net
assets in illiquid securities, including securities for which there is no
readily available secondary market. Also as a general matter, the Portfolio may
not invest more than 10% of its total assets in securities that are restricted
from sale to the public without registration ("Restricted Securities") under the
Securities Act of 1933, as amended (the "1933 Act"). However, the Portfolio may
invest up to 25% of its total assets in liquid Restricted Securities that can be
offered and sold to qualified institutional buyers under Rule 144A under the
1933 Act ("Rule 144A Securities"). The Board of Directors has adopted guidelines
and delegated to the Adviser, subject to the supervision of the Board of
Directors, the daily function of determining and monitoring the liquidity of
Rule 144A Securities. Rule 144A Securities may become illiquid if qualified
institutional buyers are not interested in acquiring the securities.
 
    REPURCHASE AGREEMENTS.  Each Portfolio may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines established by
the Fund's Board of Directors. In a repurchase agreement, the Portfolio buys a
security from a seller that has agreed to repurchase it at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of the
agreement. The term of these agreements is usually from overnight to one week
and never exceeds one year. A repurchase agreement may be viewed as a fully
collateralized loan of money by the Portfolio to the seller. The Portfolio
always receives securities with a market value at least equal to the purchase
price (including accrued interest) as collateral, and this value is maintained
during the term of the agreement. If the seller defaults and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with respect to the seller, the Portfolio's realization upon the
collateral may be delayed or limited. The Portfolio may not enter into
repurchase agreements with more than seven days to maturity if, as a result,
more than 15% of the market value of the Portfolio's net assets are invested in
these agreements and other investments for which market quotations are not
readily available or which are otherwise illiquid.
 
    TEMPORARY INVESTMENTS.  During periods in which the Adviser believes changes
in economic, financial or political conditions make it advisable, each Portfolio
may, for temporary defensive purposes, invest up to 100% of its total assets in
certain short-term and medium-term debt obligations or hold cash. The short-term
and medium-term debt obligations in which a Portfolio may invest consist of (i)
obligations of the U.S. or foreign governments, their respective agencies or
instrumentalities; (ii) money market instruments; and (iii) instruments
denominated in any currency issued by international development agencies.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  Each Portfolio may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Delivery of and payment for these securities may take
as long as a month or more after the date of the purchase commitment but will
take place no more than 120 days after the trade date. Each Portfolio will
maintain with the Custodian a segregated account of cash or liquid securities in
an amount at least equal to these commitments. The payment obligation and the
interest rates that will be received are each fixed at the time a Portfolio
enters into the commitment and no interest accrues to the Portfolio until
settlement. Thus, it is possible that the market value at the time of settlement
could be higher or lower than the purchase price if, among other factors, the
general level of interest rates has changed. It is a current policy of each
Portfolio not to enter into when-issued commitments or delayed delivery
securities exceeding in the aggregate 15% of the market value of the Portfolio's
total assets less liabilities, other than the obligations created by these
commitments.
 
                                       18
<PAGE>
                             INVESTMENT LIMITATIONS
 
    Each Portfolio is a diversified investment company under the Investment
Company Act of 1940, as amended (the"1940 Act") and is therefore subject to the
following limitations: (i) as to 75% of its total assets, a Portfolio may not
invest more than 5% of its total assets in the securities of any one issuer,
except obligations of the U.S. Government and its agencies and
instrumentalities, and (ii) a Portfolio may not own more than 10% of the
outstanding voting securities of any one issuer.
 
    Each Portfolio also operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of the
holders of a majority of such Portfolio's outstanding shares and under certain
non-fundamental investment limitations that may be changed without shareholder
approval. For additional information on fundamental and non-fundamental
investment limitations, see "Investment Limitations" in the Statement of
Additional Information.
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and each Portfolio. The Adviser provides investment
advice and portfolio management services pursuant to an Investment Advisory
Agreement and, subject to the supervision of the Fund's Board of Directors,
makes each of the Portfolio's day-to-day investment decisions, arranges for the
execution of portfolio transactions and generally manages each of the
Portfolio's investments. Set forth below as an annual percentage of average
daily net assets are the management fees payable to the Adviser quarterly by
each Portfolio pursuant to the terms of the Investment Advisory Agreement. The
Adviser has voluntarily agreed to a reduction in the fees payable to it and to
reimburse the Portfolios, if necessary, if such fees would cause total annual
operating expenses of the Portfolios to exceed the maximums set forth in the
table below.
 
<TABLE>
<CAPTION>
                                                                    MAXIMUM TOTAL ANNUAL
                                                                         OPERATING
                                                                 EXPENSES AFTER FEE WAIVERS
                                                                 --------------------------
                                              MANAGEMENT FEES
PORTFOLIO                                   ABSENT FEE WAIVERS     CLASS A       CLASS B
- ------------------------------------------  -------------------  ------------  ------------
<S>                                         <C>                  <C>           <C>
Global Equity                                        0.80%             1.00%         1.25%
International Equity                                 0.80%             1.00%         1.25%
International Small Cap                              0.95%             1.15%       N/A
European Equity                                      0.80%             1.00%         1.25%
</TABLE>
 
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to customers in the
United States and abroad. Morgan Stanley Dean Witter & Co. ("MSDW") is the
direct parent of the Adviser and Morgan Stanley. MSDW is a preeminent global
financial services firm that maintains leading market positions in each of its
three primary businesses -- securities, asset management and credit services. At
March 31, 1998, the Adviser, together with its affiliated institutional asset
management companies, managed assets of approximately $166 billion, including
assets under fiduciary advice. See "Management of the Fund" in the Statement of
Additional Information.
 
                                       19
<PAGE>
    PORTFOLIO MANAGERS.  The following individuals have primary portfolio
management responsibility for the Portfolios noted below:
 
    GLOBAL EQUITY PORTFOLIO -- FRANCES CAMPION.  Frances Campion joined the
Adviser in January 1990 as a Global Equity Fund Manager and is now a Managing
Director of the Adviser and Morgan Stanley. Her responsibilities include
day-to-day management of the Global Equity product. Prior to joining the
Adviser, Ms. Campion was a U.S. equity analyst with Lombard Odier Limited where
she had responsibility for the management of global portfolios. Ms. Campion has
ten years global investment experience. She is a graduate of University College,
Dublin.
 
    INTERNATIONAL EQUITY PORTFOLIO -- DOMINIC CALDECOTT.  Dominic Caldecott is a
Managing Director of the Adviser and Morgan Stanley and is responsible for
research and stock selection in the Pacific Basin and has been primarily
responsible for managing the Portfolio's assets since its inception. He has ten
years professional experience, primarily in Tokyo, Hong Kong, and Seoul. Prior
to joining Morgan Stanley, he worked with GT Management Group in Tokyo and Hong
Kong, specializing in Pacific Basin investment management. He became a Vice
President of Morgan Stanley in 1987, a Principal in 1989, and a Managing
Director in 1991. He is responsible for a number of Pacific Basin investment
programs for clients of Morgan Stanley. Mr. Caldecott is a graduate of New
College, Oxford, England.
 
    INTERNATIONAL SMALL CAP PORTFOLIO -- MARGARET NAYLOR.  Margaret Naylor is a
Principal of the Adviser and Morgan Stanley and works with Dominic Caldecott on
Pacific Basin research and stock selection. She joined the Adviser in March 1987
and has been primarily responsible for managing the Portfolio's assets since
December 1992. Prior to joining the Adviser she spent three years at the Trade
Policy Research Centre, an independent research unit. Ms. Naylor is a graduate
of the University of York.
 
    EUROPEAN EQUITY PORTFOLIO -- ROBERT SARGENT.  Robert Sargent joined Morgan
Stanley International in May 1986, and transferred to the Adviser in June 1987.
Mr. Sargent is now a Managing Director of the Adviser and Morgan Stanley and has
been primarily responsible for managing the Portfolio's assets since its
inception. As the fund manager with primary responsibility for continental
European stock selection and portfolio management, Mr. Sargent is closely
involved with the Adviser's fundamental research effort and company visiting
program. He is a graduate of York University, Toronto, Canada.
 
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the officers and
Board of Directors of the Fund and include day-to-day administration of matters
related to the corporate existence of the Fund, maintenance of its records,
preparation of reports, supervision of the Fund's arrangements with its
custodian and assistance in the preparation of the Fund's registration
statements under federal laws. The Administration Agreement also provides that
the Administrator, through its agents, will provide dividend disbursing and
transfer agent services to the Fund. For its services under the Administration
Agreement, the Fund pays the Adviser a monthly fee which on an annual basis
equals 0.15% of the average daily net assets of each Portfolio.
 
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors such administrative services provided by CGFSC.
Their services are also subject to the supervision of the Board of Directors of
the Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
                                       20
<PAGE>
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of each Portfolio upon the terms and at the current
offering price described in this Prospectus. Morgan Stanley is not obligated to
sell any certain number of shares of any Portfolio.
 
    The Portfolios currently offer only the classes of shares offered by this
Prospectus. The Portfolios may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares of each Multiclass Portfolio pursuant to Rule 12b-1 under the 1940 Act
(each, a "Plan"). Under each Plan, the Distributor is entitled to receive from
each Multiclass Portfolio a distribution fee, which is accrued daily and paid
quarterly, of 0.25% of the Class B shares' average daily net assets on an
annualized basis. Each Plan is designed to compensate the Distributor for its
services in connection with distribution assistance. The Distributor may retain
any portion of the fee that it does not expend in meeting its obligations to the
Fund. The Distributor may compensate financial intermediaries, plan fiduciaries
and administrators for providing distribution-related services, including
account maintenance services, to shareholders (including, where applicable,
underlying beneficial owners) of Class B shares.
 
    EXPENSES.  Each Portfolio is responsible for payment of certain other fees
and expenses (including legal fees, accountant's fees, custodial fees and
printing and mailing costs) as specified in its agreements with the Adviser and
Morgan Stanley.
 
    YEAR 2000.  The management and distribution services provided to the Fund by
the Adviser and Morgan Stanley depend on the smooth functioning of their
computer systems. Many computer software systems in use today cannot recognize
the year 2000, but revert to 1900 or some other date, due to the manner in which
dates were encoded and calculated. That failure could have a negative impact on
the handling of securities trades, pricing and account services. The Adviser and
Morgan Stanley have been actively working on necessary changes to their own
computer systems to deal with the year 2000 problem and expect that their
systems will be adapted before that date. There can be no assurance, however,
that they will be successful. In addition, other unaffiliated service providers
may be faced with similar problems. The Adviser and Morgan Stanley are
monitoring their remedial efforts, however, there can be no assurance that they
and the services they provide will not be adversely affected.
 
    In addition, it is possible that the markets for securities in which the
Portfolios invest may be detrimentally affected by computer failures throughout
the financial services industry beginning January 1, 2000. Improperly
functioning trading systems may result in settlement problems and liquidity
issues. In addition, corporate and governmental data processing errors may
result in production problems for individual companies and overall economic
uncertainties. Earnings of individual issuers will be affected by remediation
costs, which may be substantial and may be reported inconsistently in U.S. and
foreign financial statements. Accordingly, the Portfolios' investments may be
adversely affected.
 
                                       21
<PAGE>
                               PURCHASE OF SHARES
 
    Class A shares of each Portfolio and Class B shares of each Multiclass
Portfolio may be purchased at the net asset value per share next determined
after receipt by the Fund of a purchase order as described under "Methods of
Purchase." The net asset value per share of each Portfolio is calculated on days
that the New York Stock Exchange ("NYSE") and Chase (the "Custodian Bank") are
open for business as of the close of trading of the NYSE, normally 4:00 p.m.
Eastern Time (the "Pricing Time").
 
MINIMUM INVESTMENT
 
    The minimum initial investment is $500,000 for Class A shares for each
Portfolio and $100,000 for Class B shares of each Multiclass Portfolio. These
minimums may be waived at the discretion of the Adviser for certain types of
investors, including trust departments, brokers, dealers, agents, financial
planners, financial services firms, investment advisers or various retirement
and deferred compensation plans ("Financial Intermediaries"), certain accounts
managed by the Adviser and its affiliates ("Managed Accounts"), and certain
employees and customers of Morgan Stanley and its affiliates. The Fund's
determination of an investor's eligibility to purchase shares of a given class
will take precedence over the investor's selection of a class.
 
METHODS OF PURCHASE
 
    Shares may be purchased directly from the Fund by Federal Funds wire, by
bank wire or by check. Investors may also invest in the Portfolios by purchasing
shares through Financial Intermediaries that have made arrangements with Morgan
Stanley. Some Financial Intermediaries may charge an additional service or
transaction fee. If a purchase is canceled due to nonpayment or because your
check does not clear, you will be responsible for any loss the Fund or its
agents incur. If you are already a shareholder, the Fund may redeem shares from
your account(s) to reimburse the Fund or its agents for any loss. In addition,
you may be prohibited or restricted from making future investments in the Fund.
 
    FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire Federal
Funds to the Fund's bank account. Federal Funds purchase orders will be accepted
only on a day on which the Fund and the Custodian Bank are open for business.
Your bank may charge a service fee for wiring Federal Funds. In order to ensure
proper handling of your purchase by Federal Funds wire, please follow these
steps:
 
    1.    Place your order by telephoning the Fund at 1-800-548-7786. A Fund
          representative will request certain purchase information and provide
          you with a confirmation number.
 
    2.    Instruct your bank to wire the specified amount to the Fund's Wire
          Concentration Bank Account as follows:
 
          The Chase Manhattan Bank
          One Manhattan Plaza
          New York, NY 10081-1000
          ABA# 021000021
          DDA# 910-2-733293
          Attn: Morgan Stanley Institutional Fund, Inc.
          Ref: (Portfolio name, your account number, your account name)
 
          Please call the Fund at 1-800-548-7786 prior to wiring the funds.
 
    3.    Complete and sign the Account Registration Form and mail it to the
          address shown thereon.
 
                                       22
<PAGE>
    When a purchase order is received prior to the Pricing Time and Federal
Funds are received prior to the close of the Federal Funds Wire Control Center
("FFWCC") (normally 6:00 p.m. Eastern Time), the purchase will be executed at
the net asset value computed on the date of receipt. Purchases for which an
order is received after the Pricing Time or for which Federal Funds are received
after the close of the FFWCC, will be executed at the net asset value next
determined. Certain institutional investors and financial institutions have
entered into an arrangement with Morgan Stanley, pursuant to which they may
place orders prior to the Pricing Time, but make payment in Federal Funds for
those shares on the following business day.
 
    BANK WIRE.  A purchase of shares by bank wire must follow the same procedure
as for a Federal Funds wire, described above. However, depending on the time the
bank wire is sent and which bank is handling the wire, money transferred by bank
wire may or may not be converted into Federal Funds prior to the close of the
FFWCC. Prior to conversion to Federal Funds and receipt by the Fund, an
investor's money will not be invested.
 
    CHECK.  An account may be opened by completing and signing an Account
Registration Form and mailing it, together with a check payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio name]" to:
 
    Morgan Stanley Institutional Fund, Inc.
    P.O. Box 2798
    Boston, Massachusetts 02208-2798
 
    The Fund ordinarily is credited with Federal Funds within one business day
of deposit of a check. Thus, a purchase of shares by check ordinarily will be
credited to your account at the net asset value per share of each of the
Portfolios determined on the next business day after receipt. An investor's
money will not be invested prior to crediting of Federal Funds.
 
    INVESTMENT THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to receive purchase and
redemption orders from underlying beneficial owners, such as retirement plan
participants, generally on each business day. Each business evening, the
Financial Intermediary aggregates all orders received from underlying beneficial
owners prior to the Pricing Time on that business day and places a net purchase
and/or redemption order(s) by the morning of the next business day. These orders
normally are executed at the net asset value that was computed for each
Portfolio as of the close of the previous business day.
 
    ADDITIONAL INVESTMENTS.  You may purchase additional shares for your account
at any time by purchasing shares at net asset value by any of the methods
described above. The minimum additional investment generally is $1,000 per
Portfolio. The minimum additional investment may be lower for certain accounts,
described above under "Minimum Investment." For purchases directly from the
Fund, your account name, the Portfolio name and the class selected must be
specified in the letter or wire to assure proper crediting to your account.
 
INVOLUNTARY CONVERSION AND REDEMPTION OF NEW ACCOUNT SHARES
 
    Class A shares of each Portfolio and Class B shares of each Multiclass
Portfolio may be subject to the involuntary conversion and redemption features
described below. The conversion and redemption features may be waived at the
discretion of the Adviser for shares held in a Managed Account and shares
purchased through a Financial Intermediary. Accounts that were open prior to
January 2, 1996 are not subject to involuntary conversion or redemption. The
Fund reserves the right to modify or terminate the conversion or redemption
features of the shares at any time upon 60 days notice to shareholders.
 
                                       23
<PAGE>
    CONVERSION FROM CLASS A TO CLASS B SHARES.  If the value of an account
containing Class A shares, except an account for the International Small Cap
Portfolio, falls below $500,000 (but remains at or above $100,000) because of
shareholder redemption(s), the Fund will notify the shareholder, and if the
account value remains below $500,000 (but remains at or above $100,000) for a
continuous 60-day period, the Class A shares in such account will convert to
Class B shares and will be subject to the distribution fee and other features
applicable to Class B shares. The Fund will not convert Class A shares to Class
B shares based solely upon changes in the market that reduce the net asset value
of shares. Under current tax law, conversion between share classes is not a
taxable event to the shareholder.
 
    CONVERSION FROM CLASS B TO CLASS A SHARES.  If the value of an account
containing Class B shares increases to $500,000 or more, whether due to
shareholder purchases or market activity, the Class B shares will convert to
Class A shares. Class B shares purchased through a Financial Intermediary that
has entered into an arrangement with the Fund for the purchase of such shares
may not be converted. Under current tax law, such conversion is not a taxable
event to the shareholder. Class A shares converted from Class B shares are
subject to the same minimum account size requirements as are applicable to New
Accounts containing Class A shares described above.
 
    INVOLUNTARY REDEMPTION OF SHARES.  If the value of an account falls below
$100,000 because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $100,000 for a continuous
60-day period, the shares in such account will be subject to redemption by the
Fund. If the value of an account for the International Small Cap Portfolio falls
below $500,000 because of shareholder redemptions, the Fund will notify the
shareholder, and if the account value remains below $500,000 for a continuous
60-day period, the shares in such account will be subject to redemption by the
Fund. The Fund will not redeem shares based solely upon changes in the market
that reduce the net asset value of shares. If redeemed, redemption proceeds will
be promptly paid to the shareholder.
 
                              REDEMPTION OF SHARES
 
    Class A shares of each Portfolio and Class B shares of each Multiclass
Portfolio may be redeemed at any time and without charge at the net asset value
per share next determined after receipt by the Fund of a redemption order as
described under "Methods of Redemption." Redemption proceeds may be more or less
than the purchase price of your shares depending on, among other factors, the
market value of the investment securities held by a Portfolio.
 
METHODS OF REDEMPTION
 
    Shares may be redeemed directly from the Fund by mail or by telephone.
However, shares purchased through a Financial Intermediary must be redeemed
through a Financial Intermediary. Certain Financial Intermediaries may charge an
additional service or transaction fee.
 
    BY MAIL.  Each Portfolio will redeem shares upon receipt of a redemption
request in "good order." Redemption requests may be sent by regular mail to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798 or, by overnight courier, to Morgan Stanley Institutional Fund, Inc.,
c/o Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913.
 
                                       24
<PAGE>
    "Good order" means that the request to redeem shares must include the
following:
 
    1. A letter of instruction or a stock assignment specifying the class and
number of shares or dollar amount to be redeemed, signed by all registered
owners of the shares in the exact names in which they are registered;
 
    2. Any required signature guarantees; and
 
    3. Other supporting legal documents, if required, in the case of estates,
trusts, guardianships, custodianships, corporations, pension and profit-sharing
plans and other organizations.
 
    Redemption requests received in "good order" prior to the Pricing Time will
be executed at the net asset value computed on the date of receipt. Redemption
requests received after the Pricing Time will be executed at the next determined
net asset value. Shareholders who are uncertain of requirements for redemption
by mail should consult with a Fund representative.
 
    BY TELEPHONE.  If you have previously elected the Telephone Redemption
Option on the Account Registration Form, you can redeem Portfolio shares by
calling the Fund and requesting that the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. To change the commercial bank or account designated to receive
redemption proceeds, send a written request to the Fund at the address above.
Requests to change the bank or account must be signed by each shareholder and
each signature must be guaranteed. The telephone redemption option may be
difficult to implement at times, particularly during volatile market conditions.
If you experience difficulty in making a telephone redemption, you may redeem
shares by mail as described above.
 
    The Fund and the Transfer Agent will employ reasonable procedures to confirm
that instructions communicated by telephone are genuine. An investor may be
required to provide personal identification information at the time an account
is opened and prior to effecting each telephone transaction. In addition, all
telephone transaction requests will be recorded and investors may be required to
provide additional telecopied written instructions regarding transaction
requests. Neither the Fund nor the Transfer Agent will be responsible for any
loss, liability, cost or expense for following instructions received by
telephone that either of them reasonably believes to be genuine.
 
    REDEMPTION THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to accept redemption
requests from underlying beneficial owners. These redemptions may be processed
in the same way as purchases made through such Financial Intermediaries, as
described above.
 
FURTHER REDEMPTION INFORMATION
 
    The Fund normally makes payment for all shares redeemed within one business
day of receipt of the request, and in no event more than seven days after
receipt of a redemption request in good order. However, payments to investors
redeeming shares which were purchased by check will not be made until payment
for the purchase has been collected, which may take up to eight days after the
date of purchase. The Fund may suspend the right of redemption or postpone the
date upon which redemptions are effected at times when the NYSE is closed, or
under any emergency conditions as determined by the Securities and Exchange
Commission (the "Commission").
 
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of a Portfolio to make payment in
cash, the Fund may pay redemption proceeds in whole or in part
 
                                       25
<PAGE>
by a distribution-in-kind of readily marketable portfolio securities in
accordance with applicable rules of the Commission. Shareholders may incur
brokerage charges on the sale of portfolio securities received in payment of
redemptions.
 
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required to verify the identity of the person who has authorized
certain redemptions. Please contact the Fund or see the Statement of Additional
Information for further information.
 
                         ACCOUNT POLICIES AND SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares of each Portfolio that you own for shares of any
other available portfolio(s) of the Fund, subject to certain limitations. You
cannot exchange for shares of the International Equity, Emerging Markets, Small
Cap Value Equity, Balanced or Gold Portfolios because they are currently closed
to new investors. In addition, certain portfolios may be unavailable to
shareholders who purchased portfolio shares through a Financial Intermediary.
Contact your Financial Intermediary to determine which portfolios are available
for exchange.
 
    Before you make an exchange, you should read the prospectus of the
portfolio(s) in which you seek to invest. The class of shares you receive in the
exchange will be determined in the same manner as any other purchase of shares,
including minimum initial investment and account size requirements, and will not
be based on the class of shares you surrender for the exchange. Exchange
transactions are treated as a redemption followed by a purchase. Therefore, an
exchange will be considered a taxable event for shareholders subject to tax.
Exchange transactions will be processed at the net asset value per share next
determined after receipt of the request. Shares of the portfolios may be
exchanged by mail or telephone. The telephone exchange privilege is automatic
and made available without shareholder election. The exchange privilege may be
modified or terminated by the Fund at any time upon 60-days notice to
shareholders.
 
    BY MAIL.  To exchange shares by mail, send a written exchange request to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798. Your written exchange request should include (i) the name, class of
shares and account number of your current Portfolio; (ii) the name(s) and
class(es) of shares of the portfolio(s) into which you intend to exchange
shares; and (iii) the signatures of all registered account holders.
 
    BY TELEPHONE.  To exchange shares by telephone, call the Fund at the phone
number provided on the cover of this Prospectus. A Fund representative will
request (i) the name, class of shares and account number of your current
Portfolio, and (ii) the name(s) and class(es) of shares of the portfolio(s) into
which you intend to exchange shares. For additional information regarding
responsibility for the authenticity of telephoned instructions, see "Redemption
of Shares" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by sending a written request to Morgan Stanley Institutional Fund, Inc.,
P.O. Box 2798, Boston, Massachusetts 02208-2798. It may not be possible to
transfer the registration of certain shares purchased through a Financial
Intermediary. As with redemptions, the written request must be received in "good
order" before any transfer can be made. Transferring the registration of shares
may affect the eligibility of your account for a given class of shares and may
result in involuntary conversion or redemption of your shares.
 
                                       26
<PAGE>
OTHER ACCOUNT INFORMATION
 
    The Fund does not issue share certificates for the Portfolios. All shares
purchased are confirmed to you and credited to your account on the Fund's books
maintained by the Adviser or its agents. You will have the same rights and
ownership with respect to such shares as if certificates had been issued.
 
EXCESSIVE TRADING
 
    Frequent trades in your account(s) can disrupt management of a Portfolio and
raise its expenses. Consequently, the Fund may, in its discretion and in the
interest of each Portfolio's shareholders and performance, bar a shareholder who
trades excessively from making further share purchases for an indefinite period.
The Fund considers excessive trading to be more than one purchase and sale
involving shares of the same class of a portfolio of the Fund within any 120-day
period. For example, the following series of transactions would amount to
excessive trading: exchanging shares of Portfolio A for shares of Portfolio B,
then exchanging shares of Portfolio B for shares of Portfolio C and then
exchanging shares of Portfolio C for shares of Portfolio A within a 120-day
period. Two types of transactions are exempt from these excessive trading
restrictions: (i) trades exclusively between money market portfolios, and (ii)
trades made in connection with an asset allocation service managed or advised by
the Adviser and/or any of its affiliates.
 
INVESTMENT IN PORTFOLIOS BY OTHER INVESTMENT ACCOUNTS
 
    Morgan Stanley or its affiliates, including Morgan Stanley Asset Management
Inc., manage investment accounts for other clients, including other investment
companies, that invest in Class A or Class B shares of the portfolios. From time
to time, one or more of the Portfolios used for investment by these accounts may
experience relatively large investments or redemptions due to investment
decisions made on behalf of these accounts. These transactions will affect the
portfolios, since portfolios that experience significant redemptions may have to
sell portfolio securities and portfolios that receive additional cash will have
to invest it in additional portfolio securities. It is impossible to predict the
overall impact of these transactions over time, however, there could be adverse
effects on portfolio management. These transactions also could have tax
consequences if sales of portfolio securities result in gains or could increase
transaction costs. The Adviser, representing the interests of the portfolios, is
committed to minimizing the impact of these transactions to the portfolios. The
Adviser, however, will have a conflict in fulfilling this responsibility in that
it also advises these investment accounts. The Adviser will monitor the impact
of these transactions on the Portfolios.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of each of the Portfolios
is determined by dividing the total market value of the Portfolio's investments
and other assets attributable to such class, less any liabilities attributable
to such class, by the total number of outstanding shares of each class of the
Portfolio. Net asset value is calculated separately for each class of the
Portfolios. Net asset value per share is determined as of the close of the NYSE
(normally 4:00 p.m. Eastern Time) on each day that the NYSE is open for
business. Price information on listed securities is taken from the exchange
where the security is primarily traded. Securities listed on a U.S. securities
exchange for which market quotations are available are valued at the last quoted
sale price on the day the valuation is made. Securities listed on a foreign
exchange are valued at their closing price. Unlisted securities and listed
securities not traded on the valuation date and for which market quotations are
not readily available are valued at a price within a range not exceeding the
current asked price nor less than the current bid price. The current bid and
asked prices are determined based on the average of the bid and asked prices
quoted on such valuation date by reputable brokers.
 
                                       27
<PAGE>
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily. In addition, bonds and other fixed income securities may be
valued on the basis of prices provided by a pricing service when such prices are
believed to reflect the fair market value of such securities. The prices
provided by a pricing service are determined without regard to bid or last sale
prices but take into account institutional size trading in similar groups of
securities and any developments related to the specific securities. Securities
not priced in this manner are valued at the most recently quoted bid price or,
when securities exchange valuations are used, at the latest quoted sale price on
the day of valuation. If there is no such reported sale, the latest quoted bid
price will be used. Securities purchased with remaining maturities of 60 days or
less are valued at amortized cost, if it approximates market value. In the event
that amortized cost does not approximate market value, market prices as
determined above will be used.
 
    The value of other assets and securities for which quotations are not
readily available (including restricted and unlisted foreign securities) and
those securities for which it is inappropriate to determine the prices in
accordance with the above-stated procedures are determined in good faith at fair
value using methods determined by the Board of Directors. For purposes of
calculating net asset value per share, all assets and liabilities initially
expressed in foreign currencies will be translated into U.S. dollars at the mean
of the bid and asked price for such currencies against the U.S. dollar last
quoted by a major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distribution expense accrual differential among the classes. The
net asset value of Class B shares will generally be lower than the net asset
value of the Class A shares as a result of the distribution expenses charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise the "total return" for each class
of a Portfolio. THESE FIGURES ARE BASED ON HISTORICAL EARNINGS AND ARE NOT
INTENDED TO INDICATE FUTURE PERFORMANCE.
 
    Each of the Portfolios may advertise "total return" which shows what an
investment in a class of a Portfolio would have earned over a specified period
of time (such as one, five or ten years) assuming that all distributions and
dividends by the Portfolio were reinvested in the same class on the reinvestment
dates during the period. Total return does not take into account any federal or
state income taxes that may be payable on dividends and distributions or on
redemption. The Fund may also include comparative performance information in
advertising or marketing the Portfolios' shares, including data from Lipper
Analytical Services, Inc., other industry publications, business periodicals,
rating services and market indices.
 
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains distributions for a class of shares
will be automatically reinvested in additional shares at net asset value, except
when, upon written notice to the Fund or by checking off the appropriate box in
the Distribution Option Section on the Account Registration Form, a shareholder
elects to receive income dividends and capital gains distributions in cash.
 
                                       28
<PAGE>
    Each Portfolio expects to distribute substantially all of its taxable net
investment income in the form of annual dividends. Net realized capital gains,
if any, after reduction for any available tax loss carryforwards will also be
distributed annually.
 
    Undistributed net investment income is included in a Portfolio's net assets
for the purpose of calculating net asset value per share. Therefore, on the
"ex-dividend" date, the net asset value per share excludes the dividend (i.e.,
is reduced by the per share amount of the dividend). Dividends paid shortly
after the purchase of shares by an investor, although in effect a return of
capital, are taxable to shareholders subject to income tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of the Portfolios will differ at times.
Expenses of the Portfolios allocated to a particular class of shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of the Portfolios or their shareholders.
Accordingly, shareholders are urged to consult their tax advisers regarding
specific questions as to federal, state and local income taxes.
 
    Each Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other portfolios. Each Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Internal Revenue Code of 1986, as amended
(the "Code"), so that the Portfolio will be relieved of federal income tax on
that part of its net investment income and net capital gain that is distributed
to shareholders.
 
    Each Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, net short-term capital gain) to
shareholders. Dividends from a Portfolio's net investment income are taxable to
shareholders as ordinary income, whether received in cash or in additional
shares. Such dividends paid by a Portfolio will generally qualify for the
dividends-received deduction for corporate shareholders only to the extent of
the aggregate qualifying dividend income received by the Portfolio from U.S.
corporations. Each Portfolio will report annually to its shareholders the amount
of dividend income qualifying for such treatment.
 
    Distributions of net capital gain are taxable to shareholders as a 20% rate
gain distribution (taxed at a rate of 20%) or a 28% rate gain distribution
(taxed at a rate of 28%), depending upon the designation by the Portfolio (such
designation being dependent upon the holding period of the Portfolio in the
underlying asset generating the net capital gain), regardless of how long
shareholders have held their shares. Each Portfolio will send reports annually
to its shareholders of the federal income tax status of all distributions made
during the preceding year.
 
    Each Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gain over short-term and long-term capital
loss, including any available capital loss carryforwards) prior to the end of
each calendar year to avoid liability for federal excise tax.
 
                                       29
<PAGE>
    Dividends and other distributions declared by a Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders in that year if the distributions are paid by the Portfolio at
any time during the following January.
 
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any dividends, capital gains distributions and redemption proceeds paid to any
individual or certain other non-corporate shareholder (i) who has failed to
provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Account Registration Form; (ii) who is subject to backup withholding by the
Internal Revenue Service; or (iii) who has not certified to the Fund that such
shareholder is not subject to backup withholding. This backup withholding is not
an additional tax, and any amounts withheld may be credited against the
shareholder's ultimate U.S. tax liability.
 
    The sale, exchange or redemption of shares will result in taxable gain or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the sale, exchange or redemption proceeds exceed or are
less than the shareholder's tax adjusted basis in the sold, exchanged or
redeemed shares. If capital gains distributions have been made with respect to
shares that are sold at a loss after being held for six months or less, then the
loss is treated as a long-term capital loss to the extent of the capital gains
distributions.
 
    Conversions of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisors concerning the
application of state and local income taxes to investments in a Portfolio, which
may differ from the federal income tax consequences described above.
 
    Investment income received by a Portfolio from sources within foreign
countries may be subject to foreign income taxes withheld at the source. To the
extent that a Portfolio is liable for foreign income taxes so withheld, each
Portfolio intends to operate so as to meet the requirements of the Code to pass
through to the shareholders credit for foreign income taxes paid. Although each
Portfolio intends to meet Code requirements to pass through credit for such
taxes, there can be no assurance that each Portfolio will be able to do so.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN A PORTFOLIO.
 
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolio
for their clients.
 
                                       30
<PAGE>
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other remuneration paid to Morgan Stanley or other affiliates must be
fair and reasonable in comparison to those of other broker-dealers for
comparable transactions involving similar securities being purchased or sold
during a comparable time period.
 
PORTFOLIO TURNOVER
 
    The Portfolios generally do not invest for short-term trading purposes,
however, when circumstances warrant, each Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolios will not consider portfolio turnover rate
a limiting factor in making investment decisions consistent with their
respective objectives and policies. Higher portfolio turnover (e.g., over 100%)
necessarily will cause the Portfolios to pay correspondingly increased brokerage
and trading costs. In addition to transaction costs, higher portfolio turnover
may result in the realization of capital gains. As discussed under "Taxes," to
the extent net short-term capital gains are realized, any distributions
resulting from such gains are considered ordinary income for federal income tax
purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 40 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of each
Portfolio are currently classified into two classes, the Class A shares and the
Class B shares, except for the International Small Cap and Municipal Money
Market Portfolios, which offer only Class A shares.
 
    The shares of each Portfolio, when issued, will be fully paid,
nonassessable, fully transferable and redeemable at the option of the holder.
The shares have no preference as to conversion, exchange, dividends, retirement
or other features and have no pre-emptive rights. The shares of each Portfolio
have non-cumulative voting rights, which means that the holders of more than 50%
of the shares voting for the election of Directors can elect 100% of the
Directors if they choose to do so. Persons or organizations owning 25% or more
of the outstanding shares of a Portfolio may be presumed to "control" (as
defined in the 1940 Act) such Portfolio. Under Maryland law, the Fund is not
required to hold an annual meeting of its shareholders unless required to do so
under the 1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual and semi-annual reports. The
financial statements appearing in annual reports are audited by independent
accountants. Monthly unaudited portfolio data is also available from the Fund
upon request.
 
    In addition, the Adviser or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
                                       31
<PAGE>
CUSTODIAN
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs sub-custodians approved by the Board of Directors of the Fund
in accordance with regulations of the Securities and Exchange Commission for the
purpose of providing custodial services for such assets. MSTC may also hold
certain domestic assets for the Fund. For more information on the custodians,
see "General Information -- Custody Arrangements" in the Statement of Additional
Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits its annual financial statements.
 
FUND COUNSEL
 
    Morgan, Lewis & Bockius LLP acts as the Fund's legal counsel.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       32
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
        GLOBAL EQUITY, INTERNATIONAL EQUITY, INTERNATIONAL SMALL CAP AND
        EUROPEAN EQUITY PORTFOLIOS
        P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                            <C>
      ACCOUNT INFORMATION                            If you need assistance in filling out this form for the Morgan Stanley
      Fill in where applicable                       Institutional Fund, Inc., please contact your Morgan Stanley
                                                     representative or call us toll free 1-800-548-7786. Please print all
                                                     items except signature, and mail to the Fund at the address above.
 
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
         TENANCY IN COMMON
         IS INDICATED)
</TABLE>
 
1.
         First Name    Initial         Last Name
 
2.
         First Name    Initial         Last Name
 
         First Name    Initial         Last Name
 
<TABLE>
<C>   <S>                                            <C>
      3. CORPORATIONS,
         TRUSTS AND OTHERS
         Please call the Fund for additional
         documents that may be required to set up
         account and to authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                     <C>                 <C>                   <C>               <C>
Type of Registration:   / / INCORPORATED    / / UNINCORPORATED    / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                                ASSOCIATION                            (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
 
<TABLE>
<C>   <S>                                            <C>
  B)  MAILING ADDRESS
      Please fill in completely, including
      telephone number(s).
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
 
/ / Non-Resident Alien
 
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
 
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
 
<TABLE>
<S>  <S>                                  <C>                                  <C>
  C) TAXPAYER                             Enter your Taxpayer Identification Number. For most individual taxpayers, this
     IDENTIFICATION                       is your Social Security Number.
     NUMBER
     1.   INDIVIDUAL
     2.   JOINT TENANTS
          (RIGHTS OF SURVIVORSHIP
          PRESUMED UNLESS
          TENANCY IN COMMON
          IS INDICATED)
</TABLE>
<PAGE>
<TABLE>
<S>  <S>                                  <C>                                  <C>
     For Custodian account
     of a minor (Uniform
     Gifts/Transfers to Minor
     Acts), give the Social
     Security Number of
     the minor.
 
                                          1. TAXPAYER IDENTIFICATION NUMBER ("TIN")  OR  SOCIAL SECURITY NUMBER ("SSN")
 
                                          2.                  TIN                    OR                SSN
 
                                                              TIN                    OR                SSN
 
                                                                    IMPORTANT TAX INFORMATION
                                            You (as a payee) are required by law to provide us (as payer) with your
                                          correct TIN(s) or SSN(s). Accounts that have a missing or incorrect TIN(s) or
                                          SSN(s) will be subject to backup withholding at a 31% rate on dividends,
                                          distributions and other payments. If you have not provided us with your
                                          correct TIN(s) or SSN(s), you may be subject to a $50 penalty imposed by the
                                          Internal Revenue Service.
                                            Backup withholding is not an additional tax; the tax liability of persons
                                          subject to backup withholding will be reduced by the amount of tax withheld.
                                          If withholding results in an overpayment of taxes, a refund may be obtained.
                                            You may be notified that you are subject to backup withholding under Section
                                          3406(a)(1)(C) of the Internal Revenue Code because you have underreported
                                          interest or dividends or you were required to, but failed to, file a return
                                          which would have included a reportable interest or dividend payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>                             <C>                   <C>
  D)  PORTFOLIO AND                        For Purchase of the following   / / Class A Shares $  / / Class B Shares $
      CLASS SECTION                        Portfolio(s):                   / / Class A Shares $  / / Class B Shares $
      (Class A shares minimum $500,000     Global Equity Portfolio         / / Class A Shares $
      for each Portfolio and Class B       International Equity Portfolio  / / Class A Shares $  / / Class B Shares $
      shares minimum $100,000 for the      International Small Cap
      Global Equity, International         Portfolio
      Equity, and European Equity          European Equity Portfolio
      Portfolios). Please indicate
      Portfolio, class and amount.
                                                                           Total Initial Investment $
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate portfolio
      and manner of payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                          <C>
/ / Exchange $____________ From  ________________                                       -- - - - - - - - - - -- - -
                                 Name of Portfolio                                              Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on                 -- - - - - - - - - - -- - -
                                                                                               Account No.               (Check
                                                                                   (Previously assigned by the Fund)     Digit)
                                                              _________
                                                                   Date
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  F)  DISTRIBUTION               Income dividends and capital gains distributions (if any) to
      OPTION                     be reinvested in additional shares unless either box below
                                 is checked.
                                 / / Income dividends to be paid in cash, capital gains
                                 distributions (if any) in shares.
                                 / / Income dividends and capital gains distributions (if
                                 any) to be paid in cash.
</TABLE>
 
<TABLE>
<C>   <S>                             <C>                                       <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and    __________________________
      REDEMPTION                        its agents to honor any telephone       Name of COMMERCIAL Bank (Not Savings
      AND EXCHANGE                      requests to wire redemption proceeds    Bank)
      OPTION                            to the commercial bank indicated at     __________________________
      Please select at time of          right and/or mail redemption proceeds   Bank Account No.
      initial application if you        to the name and address in which        __________________________
      wish to redeem or exchange        my/our fund account is registered if    Bank ABA No.
      shares by telephone. A            such requests are believed to be        __________________________
      SIGNATURE GUARANTEE IS            authentic.                              Name(s) in which your Bank Account is
      REQUIRED IF BANK ACCOUNT IS     The Fund and the Fund's Transfer Agent    Established
      NOT REGISTERED IDENTICALLY TO   will employ reasonable procedures to      __________________________
      YOUR FUND ACCOUNT.              confirm that instructions communicated    Bank's Street
                                      by telephone are genuine. These           Address
      TELEPHONE REQUESTS FOR          procedures include requiring the          __________________________
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal      City      State      Zip
      NOT BE HONORED UNLESS THE BOX   identification information at the time
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  H)  INTERESTED PARTY                     _____________________________________
      OPTION                               Name
      In addition to the account           _____________________________________
      statement sent to my/our registered  _____________________________________
      address, I/we hereby authorize the   Address
      Fund to mail duplicate statements    _____________________________________
      to the name and address provided at  City         State         Zip Code
      right.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  I)  DEALER
      INFORMATION
                                           ___________________         ___________________        ___________________
                                           Representative Name         Representative No.         Branch No.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
</TABLE>
 
<TABLE>
<S>                                  <C>
The undersigned certify that I/we have full authority and legal capacity
to purchase and redeem shares of the Fund and affirm that I/we have
received a current Prospectus of the Morgan Stanley Institutional Fund,
Inc. and agree to be bound by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF
PERJURY THAT THE INFORMATION ON THIS APPLICATION IS COMPLETE AND CORRECT
AND THAT AS REQUIRED BY FEDERAL LAW (PLEASE CHECK APPLICABLE BOXES
BELOW):
 
/ / U.S. CITIZEN(S)/TAXPAYER(S):
 
      / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM
          IS/ARE THE CORRECT SSN(S) OR TIN(S) AND (2) I/WE ARE NOT
          SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE ARE
          EXEMPT FROM BACKUP WITHHOLDING; (B) I/WE HAVE NOT BEEN
          NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT I/WE ARE
          SUBJECT TO BACKUP WITHHOLDING AS A RESULT OF A FAILURE TO
          REPORT ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED
          ME/US THAT I AM/WE ARE NO LONGER SUBJECT TO BACKUP
          WITHHOLDING.
 
      / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE HAVE
          APPLIED, OR INTEND TO APPLY, TO THE IRS OR THE SOCIAL SECURITY
          ADMINISTRATION FOR A TIN OR A SSN AND I/WE UNDERSTAND THAT IF
          I/ WE DO NOT PROVIDE EITHER NUMBER TO CHASE GLOBAL FUNDS
          SERVICES COMPANY ("CGFSC") WITHIN 60 DAYS OF THE DATE OF THIS
          APPLICATION OR IF I/WE FAIL TO FURNISH MY/OUR CORRECT SSN(S)
          OR TIN(S), I/WE MAY BE SUBJECT TO A PENALTY AND A 31% BACKUP
          WITHHOLDING ON DISTRIBUTIONS AND REDEMPTION PROCEEDS. (PLEASE
          PROVIDE EITHER NUMBER ON IRS FORM W-9). YOU MAY REQUEST SUCH
          FORM BY CALLING CGFSC AT 800-282-4404.
 
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
 
  UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S.
  CITIZENS OR RESIDENTS AND I/WE ARE EXEMPT FOREIGN PERSONS AS DEFINED
  BY THE INTERNAL REVENUE SERVICE.
 
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY
PROVISION OF THIS DOCUMENT OTHER THAN THE CERTIFICATIONS REQUIRED TO
AVOID BACKUP WITHHOLDING.
 
Sign Here
 
(X)_________________________________ (X)_________________________________
Signature            Date            Signature (if joint account, both
                                     must sign)      Date
</TABLE>
<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<CAPTION>
                                                    PAGE
                                                    ----
<S>                                                 <C>
Fund Expenses.....................................    2
Financial Highlights..............................    5
Prospectus Summary................................   10
Investment Objectives and Policies................   14
Additional Investment Information.................   15
Investment Limitations............................   19
Management of the Fund............................   19
Purchase of Shares................................   22
Redemption of Shares..............................   24
Account Policies and Services.....................   26
Valuation of Shares...............................   27
Performance Information...........................   28
Dividends and Capital Gains Distributions.........   28
Taxes.............................................   29
Portfolio Transactions............................   30
General Information...............................   31
Account Registration Form
</TABLE>
 
                            GLOBAL EQUITY PORTFOLIO
                         INTERNATIONAL EQUITY PORTFOLIO
                       INTERNATIONAL SMALL CAP PORTFOLIO
                           EUROPEAN EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
 
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
 
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
 
                              Morgan Stanley & Co.
                                  Incorporated
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                      P.O. BOX 2798, BOSTON, MA 02208-2798
 
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
- --------------------------------------------------------------------------------
 
                           EMERGING MARKETS PORTFOLIO
                        EMERGING MARKETS DEBT PORTFOLIO
                            LATIN AMERICAN PORTFOLIO
 
                               PORTFOLIOS OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
                                ----------------
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a series of diversified and non-diversified investment portfolios
("portfolios"). The Fund is designed to provide clients with attractive
alternatives for meeting their investment needs. The Fund currently consists of
thirty-two portfolios representing a broad range of investment choices. This
prospectus (the "Prospectus") pertains to the Class A and the Class B shares of
the Emerging Markets, Emerging Markets Debt and Latin American Portfolios (each,
a "Portfolio" and collectively, the "Portfolios"). The Emerging Markets
Portfolio is currently closed to new investors with the exception of certain
Morgan Stanley & Co. Incorporated ("Morgan Stanley") customers, employees of
Morgan Stanley, certain tax-qualified retirement plans and other investment
companies advised by Morgan Stanley Asset Management Inc. and its affiliates.
The Class A and Class B shares currently offered by the Portfolios have
different minimum investment requirements and fund expenses. Shares of the
Portfolios are offered with no sales charge, exchange fee.
 
    THE EMERGING MARKETS PORTFOLIO MAY INVEST IN EQUITY SECURITIES OF RUSSIAN
COMPANIES. RUSSIA'S SYSTEM OF SHARE REGISTRATION AND CUSTODY INVOLVES CERTAIN
RISKS OF LOSS THAT ARE NOT NORMALLY ASSOCIATED WITH INVESTMENTS IN OTHER
SECURITIES MARKETS. SEE "ADDITIONAL INVESTMENT INFORMATION -- RUSSIAN SECURITIES
TRANSACTIONS."
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator") and with Morgan Stanley as Distributor, the Fund makes
available to institutional and high net worth individual investors a series of
portfolios which benefit from the investment expertise and commitment to
excellence associated with Morgan Stanley and its affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under the "Prospectus Summary" below. The
Fund currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL
EQUITY -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging
Markets, European Equity, European Real Estate, Global Equity, International
Equity, International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) BALANCED -- Balanced Portfolio; (iv)
FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global Fixed Income, High
Yield and Municipal Bond Portfolios; and (v) MONEY MARKET -- Money Market and
Municipal Money Market Portfolios. Additional information about the Fund is
contained in a "Statement of Additional Information," dated May 1, 1998, which
is incorporated herein by reference. The Statement of Additional Information and
the prospectuses pertaining to the other portfolios of the Fund are available
upon request and without charge by writing or calling the Fund at the address
and telephone number set forth above.
 
   THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
       AND EXCHANGE COMMISSION, NOR HAS THE SECURITIES AND EXCHANGE
            COMMISSION PASSED UPON THE ACCURACY OR ADEQUACY OF THIS
                PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY
                IS A
                                       CRIMINAL OFFENSE.
 
                   THE DATE OF THIS PROSPECTUS IS MAY 1, 1998
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates the expenses and fees that a shareholder of
the Portfolios indicated below will incur:
<TABLE>
<CAPTION>
                                                                                   EMERGING
                                                                      EMERGING      MARKETS       LATIN
                                                                       MARKETS       DEBT       AMERICAN
SHAREHOLDER TRANSACTION EXPENSES                                      PORTFOLIO    PORTFOLIO    PORTFOLIO
- -------------------------------------------------------------------  -----------  -----------  -----------
<S>                                                                  <C>          <C>          <C>
Maximum Sales Load Imposed on Purchases
  Class A..........................................................        None         None         None
  Class B..........................................................        None         None         None
Maximum Sales Load Imposed on Reinvested Dividends
  Class A..........................................................        None         None         None
  Class B..........................................................        None         None         None
Deferred Sales Load
  Class A..........................................................        None         None         None
  Class B..........................................................        None         None         None
Redemption Fees
  Class A..........................................................        None         None         None
  Class B..........................................................        None         None         None
Exchange Fees
  Class A..........................................................        None         None         None
  Class B..........................................................        None         None         None
 
<CAPTION>
 
ANNUAL FUND OPERATING EXPENSES
- -------------------------------------------------------------------
 (AS A PERCENTAGE OF AVERAGE NET ASSETS)
<S>                                                                  <C>          <C>          <C>
Management Fee (Net of Fee Waivers)*
  Class A..........................................................       1.25%        1.00%        0.84%
  Class B..........................................................       1.25%        1.00%        0.84%
12b-1 Fees
  Class A..........................................................        None         None         None
  Class B..........................................................       0.25%        0.25%        0.25%
Other Expenses
  Class A..........................................................       0.50%        0.60%      0.86%**
  Class B..........................................................       0.50%        0.60%      0.86%**
                                                                     -----------  -----------  -----------
Total Operating Expenses (Net of Fee Waivers)*
  Class A..........................................................       1.75%        1.60%        1.70%
  Class B..........................................................       2.00%        1.91%        1.95%
                                                                     -----------  -----------  -----------
                                                                     -----------  -----------  -----------
</TABLE>
 
- ------------------------------
 *The Adviser has agreed to waive its management fees and/or reimburse the
  Portfolios, if necessary, if such fees would cause total annual operating
  expenses, as a percentage of average daily net assets, to exceed 1.75% for the
  Class A shares and 2.00% for the Class B shares of the Emerging Markets and
  Emerging Markets Debt Portfolios or to exceed 1.70% for the Class A shares and
  1.95% for the Class B shares of the Latin American Portfolio. The management
  fees are 1.25% for the Emerging Markets Portfolio and 1.00% for the Emerging
  Markets Debt Portfolio. Absent the fee waiver and/or expense reimbursement,
  the Latin American Portfolio's management fee would be 1.10% and total
  operating expenses would be 1.96% of the average daily net assets of the Class
  A shares and 2.21% of the average daily net assets of the Class B shares. As a
  result of these reductions, the Management Fee for the Latin American
  Portfolio stated above is lower than the contractual fee stated under
  "Management of the Fund." The Adviser reserves the right to terminate any of
  its fee waivers and/or expense reimbursements at any time in its sole
  discretion. For further information on Fund expenses, see "Management of the
  Fund."
**Other expenses for the fiscal year ended December 31, 1997 would have been
  1.05% if certain expenses not expected to recur in 1998 had been included.
 
                                       2
<PAGE>
    The purpose of the table above is to assist the investor in understanding
the various expenses that an investor in the Portfolios will bear directly or
indirectly. Expenses and fees for each Portfolio are based on actual figures for
the fiscal year ended December 31, 1997. Due to the continuous nature of Rule
12b-1 fees, long-term Class B shareholders may pay more than the equivalent of
the maximum front-end sales charges otherwise permitted by the National
Association of Securities Dealers, Inc. ("NASD") Conduct Rules.
 
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (i) a 5% annual rate of return, and (ii) redemption
at the end of each time period. As noted in the table above, the Portfolios
charge no redemption fees of any kind. The following example is based on total
operating expenses of the Portfolios after fee waivers.
 
<TABLE>
<CAPTION>
                                                                       1 YEAR       3 YEARS      5 YEARS     10 YEARS
                                                                     -----------  -----------  -----------  -----------
<S>                                                                  <C>          <C>          <C>          <C>
Emerging Markets Portfolio
  Class A..........................................................   $      18    $      55    $      95    $     206
  Class B..........................................................          20           63          108          233
Emerging Markets Debt Portfolio
  Class A..........................................................          16           50           87          190
  Class B..........................................................          19           60          103          223
Latin American Portfolio
  Class A..........................................................          17           54           92          201
  Class B..........................................................          20           61          105          227
</TABLE>
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. ACTUAL EXPENSES MAY BE GREATER OR LESS THAN THOSE
SHOWN.
 
                                       3
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following tables provide financial highlights for the Class A and Class
B shares for the Emerging Markets, Emerging Markets Debt and Latin American
Portfolios for each of the periods presented. The audited financial highlights
for each of the Portfolio's shares for each of the periods in the five years
ended December 31, 1997 are part of the Fund's financial statements which appear
in the Fund's December 31, 1997 Annual Report to Shareholders and which are
incorporated by reference into the Fund's Statement of Additional Information.
Each Portfolio's financial highlights for each of the periods presented have
been audited by Price Waterhouse LLP, whose unqualified report thereon is also
incorporated by reference into the Statement of Additional Information.
Additional performance information is included in the Annual Report. The Annual
Report and the financial statements therein, along with the Statement of
Additional Information, are available at no cost from the Fund at the address
and telephone number noted on the cover page of this Prospectus. After October
31, 1992, the Fund changed its fiscal year end to December 31. The following
information should be read in conjunction with the financial statements and
notes thereto.
 
                                       4
<PAGE>
                           EMERGING MARKETS PORTFOLIO
 
<TABLE>
<CAPTION>
                                                           CLASS A                                              CLASS B
                      ---------------------------------------------------------------------------------   -------------------
 
                                                                                                                      PERIOD
                                                                                                PERIOD                 FROM
                                                                                      TWO        FROM                JANUARY
                                                                                     MONTHS    SEPTEMBER    YEAR        2,
                                                                                     ENDED       25,       ENDED     1996***
                                        YEAR ENDED DECEMBER 31,                     DECEMBER   1992* TO   DECEMBER      TO
                      -----------------------------------------------------------     31,      OCTOBER      31,      DECEMBER
                        1997         1996         1995        1994        1993        1992     31, 1992     1997     31, 1996
                      ---------   -----------   ---------   ---------   ---------   --------   --------   --------   --------
<S>                   <C>         <C>           <C>         <C>         <C>         <C>        <C>        <C>        <C>
NET ASSET VALUE,
 BEGINNING OF
 PERIOD.............  $  14.66    $    13.14    $  16.30    $  19.00    $  10.22    $ 10.11    $ 10.00    $ 14.66    $ 13.25
                      ---------   -----------   ---------   ---------   ---------   --------   --------   --------   --------
INCOME FROM
 INVESTMENT
 OPERATIONS
  Net Investment
   Income (Loss)
   (1)..............      0.07          0.09        0.08       (0.04)      (0.01)        --         --       0.02       0.04
  Net Realized and
   Unrealized Gain
   (Loss) on
   Investments......     (0.29)         1.51       (2.05)      (1.69)       8.79       0.11       0.11      (0.28)      1.42
                      ---------   -----------   ---------   ---------   ---------   --------   --------   --------   --------
    Total from
     Investment
     Operations.....     (0.22)         1.60       (1.97)      (1.73)       8.78       0.11       0.11      (0.26)      1.46
                      ---------   -----------   ---------   ---------   ---------   --------   --------   --------   --------
DISTRIBUTIONS
  Net Investment
   Income...........     (0.07)        (0.08)      (0.06)         --          --         --         --      (0.05)     (0.05)
  In Excess of Net
   Investment
   Income...........     (0.07)           --          --          --          --         --         --      (0.04)        --
  Net Realized
   Gain.............     (0.69)           --       (1.13)      (0.97)         --         --         --      (0.69)        --
  In Excess of Net
   Realized Gain....     (0.64)           --          --          --          --         --         --      (0.64)        --
                      ---------   -----------   ---------   ---------   ---------   --------   --------   --------   --------
    Total
    Distributions...     (1.47)        (0.08)      (1.19)      (0.97)         --         --         --      (1.42)     (0.05)
                      ---------   -----------   ---------   ---------   ---------   --------   --------   --------   --------
NET ASSET VALUE, END
 OF PERIOD..........  $  12.97    $    14.66    $  13.14    $  16.30    $  19.00    $ 10.22    $ 10.11    $ 12.98    $ 14.66
                      ---------   -----------   ---------   ---------   ---------   --------   --------   --------   --------
TOTAL RETURN........     (1.03)%       12.19%     (12.77)%     (9.63)%     85.91%      1.09%      1.10%     (1.31)%    11.04%
                      ---------   -----------   ---------   ---------   ---------   --------   --------   --------   --------
                      ---------   -----------   ---------   ---------   ---------   --------   --------   --------   --------
RATIOS AND
 SUPPLEMENTAL DATA:
  Net Assets, End of
   Period
   (Thousands)......  $1,501,386  $1,304,006    $876,591    $929,638    $735,352    $74,219    $28,806     $9,666    $14,213
  Ratio of Expenses
   to Average Net
   Assets (1).......      1.75%         1.74%       1.72%       1.75%       1.75%      1.75%**    1.75%**    2.00%      1.99%**
  Ratio of Net
   Investment Income
   (Loss) to Average
   Net Assets (1)...      0.40%         0.69%       0.60%      (0.26)%     (0.06)%    (0.33)%**   (0.53)%**    0.11%    0.33%**
  Portfolio Turnover
   Rate.............        90%           55%         54%         32%         52%         2%         0%        90%        55%
  Average Commission
   Rate Per
   Share#...........   $0.0016       $0.0006         N/A         N/A         N/A        N/A        N/A    $0.0016    $0.0006
  Average Commission
   Rate as a
   Percentage of
   Trade Amount#....      0.38%         0.42%        N/A         N/A         N/A        N/A        N/A       0.38%      0.42%
</TABLE>
 
- --------------------
 
<TABLE>
<C>  <S>                <C>           <C>         <C>         <C>         <C>         <C>        <C>        <C>        <C>
(1)  Effect of
      voluntary
      expense
      limitation
      during the
      period:
       Per share
        benefit to net
        investment
        loss..........         N/A         N/A        N/A         N/A       $0.01      $0.00      $0.02        N/A        N/A
     Ratios before
      expense
      limitation:
       Expenses to
        Average Net
        Assets........         N/A         N/A        N/A         N/A        1.79  %    2.48  %**   4.82  %**    N/A      N/A
       Net Investment
        Loss to
        Average Net
        Assets........         N/A         N/A        N/A         N/A       (0.10  )%  (1.06  )%**  (3.60  )%**    N/A    N/A
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period.
 
                                       5
<PAGE>
                        EMERGING MARKETS DEBT PORTFOLIO
 
<TABLE>
<CAPTION>
                                                       CLASS A                                   CLASS B
                                -----------------------------------------------------   -------------------------
 
                                                                          PERIOD FROM                 PERIOD FROM
                                                                          FEBRUARY 1,   YEAR ENDED    JANUARY 2,
                                        YEAR ENDED DECEMBER 31,            1994* TO      DECEMBER     1996*** TO
                                ---------------------------------------    DECEMBER         31,        DECEMBER
                                   1997          1996          1995        31, 1994        1997        31, 1996
                                -----------   -----------   -----------   -----------   -----------   -----------
<S>                             <C>           <C>           <C>           <C>           <C>           <C>
NET ASSET VALUE, BEGINNING OF
 PERIOD.......................  $     7.54      $   8.59      $   8.59      $  10.00      $   7.53      $   8.68
                                -----------   -----------   -----------   -----------   -----------   -----------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Income.......        0.74          1.54          1.36          0.50          0.69          1.01
  Net Realized and Unrealized
   Gain (Loss) on
   Investments................        0.55          2.79          0.91         (1.91)         0.59          3.20
                                -----------   -----------   -----------   -----------   -----------   -----------
    Total from Investment
     Operations...............        1.29          4.33          2.27         (1.41)         1.28          4.21
                                -----------   -----------   -----------   -----------   -----------   -----------
DISTRIBUTIONS
  Net Investment Income.......       (0.71)        (1.17)        (1.86)           --         (0.69)        (1.15)
  In Excess of Net Investment
   Income.....................          --         (0.01)           --            --            --         (0.01)
  Net Realized Gain...........       (2.17)        (4.20)        (0.41)           --         (2.17)        (4.20)
  In Excess of Net Realized
   Gain.......................       (0.08)           --            --            --         (0.08)           --
  Return of Capital...........       (0.10)           --            --            --         (0.10)           --
                                -----------   -----------   -----------   -----------   -----------   -----------
    Total Distributions.......       (3.06)        (5.38)        (2.27)           --         (3.04)        (5.36)
                                -----------   -----------   -----------   -----------   -----------   -----------
NET ASSET VALUE, END OF
 PERIOD.......................  $     5.77      $   7.54      $   8.59      $   8.59      $   5.77      $   7.53
                                -----------   -----------   -----------   -----------   -----------   -----------
                                -----------   -----------   -----------   -----------   -----------   -----------
TOTAL RETURN..................       18.29%        50.52%        28.23%       (14.10)%       18.05%        48.52%
                                -----------   -----------   -----------   -----------   -----------   -----------
                                -----------   -----------   -----------   -----------   -----------   -----------
RATIO AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)................    $142,382      $152,142      $181,878      $144,949        $2,281        $4,253
  Ratio of Expenses to Average
   Net Assets.................        1.60%         2.70%         1.75%         1.49%**       1.91%         2.81%**
  Ratio of Net Investment
   Income to Average Net
   Assets.....................        8.06%        11.66%        14.70%         9.97%**       7.87%        11.09%**
  Portfolio Turnover Rate.....         417%          560%          406%          273%          417%          560%
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
                                       6
<PAGE>
                            LATIN AMERICAN PORTFOLIO
 
<TABLE>
<CAPTION>
                                                CLASS A                            CLASS B
                                ---------------------------------------   -------------------------
 
                                                            PERIOD FROM
                                                            JANUARY 18,                 PERIOD FROM
                                                             1995* TO     YEAR ENDED    JANUARY 2,
                                 YEAR ENDED DECEMBER 31,     DECEMBER      DECEMBER     1996*** TO
                                -------------------------       31,           31,        DECEMBER
                                   1997          1996          1995          1997        31, 1996
                                -----------   -----------   -----------   -----------   -----------
<S>                             <C>           <C>           <C>           <C>           <C>
NET ASSET VALUE, BEGINNING OF
 PERIOD.......................  $    11.32    $     9.06    $    10.00    $    11.31    $     9.44
                                -----------   -----------   -----------   -----------   -----------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Income (Loss)
   (1)........................       (0.01)         0.14          0.05            --          0.09
  Net Realized and Unrealized
   Gain (Loss) on
   Investments................        4.32          4.27         (0.92)         4.21          3.90
                                -----------   -----------   -----------   -----------   -----------
    Total from Investment
     Operations...............        4.31          4.41         (0.87)         4.21          3.99
                                -----------   -----------   -----------   -----------   -----------
DISTRIBUTIONS
  Net Investment Income.......          --         (0.13)        (0.04)           --         (0.10)
  Net Realized Gain...........       (4.04)        (2.02)           --         (4.04)        (2.02)
  In Excess of Net Realized
   Gain.......................       (0.68)           --            --         (0.68)           --
  Return of Capital...........          --            --         (0.03)           --            --
                                -----------   -----------   -----------   -----------   -----------
    Total Distributions.......       (4.72)        (2.15)        (0.07)        (4.72)        (2.12)
                                -----------   -----------   -----------   -----------   -----------
Net Asset Value, End of
 Period.......................  $    10.91    $    11.32    $     9.06    $    10.80    $    11.31
                                -----------   -----------   -----------   -----------   -----------
                                -----------   -----------   -----------   -----------   -----------
Total Return..................       41.28%        48.77%        (8.68)%       40.37%        42.44%
                                -----------   -----------   -----------   -----------   -----------
                                -----------   -----------   -----------   -----------   -----------
Ratios and Supplemental Data:
  Net Assets, End of Period
   (Thousands)................  $   73,196    $   30,409    $   15,376        $6,709        $1,333
  Ratio of Expenses to Average
   Net Assets (1).............        1.89%         1.70%         1.70%**       2.14%         1.95%**
  Ratio of Expenses to Average
   Net Assets Excluding
   Country Tax Expense and
   Interest Expense...........        1.70%         1.70%         1.70%**       1.95%         1.95%**
  Ratio of Net Investment
   Income (Loss) to Average
   Net Assets (1).............       (0.14)%        1.21%         1.62%**      (0.34)%        0.89%**
  Portfolio Turnover Rate.....         286%          192%          137%          286%          192%
  Average Commission Rate Per
   Share#.....................     $0.0007       $0.0004           N/A       $0.0007       $0.0004
</TABLE>
 
- ------------------
 
<TABLE>
<S>                             <C>           <C>           <C>           <C>           <C>
Average Commission Rate as a
 Percentage of Trade
 Amount#......................       0.27  %       0.30  %        N/A          0.27  %       0.30  %
</TABLE>
 
<TABLE>
<C> <S>                             <C>           <C>            <C>            <C>           <C>
(1) Effect of voluntary expense
     limitation during the period:
      Per share benefit to net
       investment income..........       $0.01         $0.05          $0.09         $0.00  +      $0.05
    Ratios before expense
     limitation:
      Expenses to Average Net
       Assets.....................       1.96  %        2.18  %        3.13  %**      2.21  %      2.43  %**
      Net Investment Income (Loss)
       to Average Net Assets......      (0.21  )%       0.75  %       (0.48  )%**     (0.41  )%      0.42  %**
</TABLE>
 
- --------------------------------------------------------------------------------
 
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period.
 
  + Amount is less than $0.01 per share.
 
                                       7
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and high net worth individual investors a broad range of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates providing customized services as Adviser, Administrator and
Distributor. Each portfolio offers Class A shares and Class B shares, except for
the International Small Cap and Municipal Money Market Portfolios which offer
only Class A shares. Each portfolio has its own investment objective and
policies designed to meet its specific goals. The investment objective of each
Portfolio described in this Prospectus is as follows:
 
    -The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of emerging country issuers.
 
    -The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by investing
     primarily in debt securities of government, government-related and
     corporate issuers located in emerging countries.
 
    -The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Latin American issuers and,
     from time to time, debt securities issued or guaranteed by Latin American
     governments or governmental entities.
 
    The other portfolios of the Fund are described in other prospectuses which
may be obtained from the Fund at the address and telephone number noted on the
cover page of this Prospectus. The investment objectives of these other
portfolios are listed below:
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    -The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
     appreciation by investing in accordance with country weightings determined
     by the Adviser in equity securities of non-U.S. issuers which, in the
     aggregate, replicate broad country indices.
 
    -The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Asian issuers.
 
    -The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
     appreciation by investing primarily in equity securities of companies in
     the Asian real estate industry.
 
    -The CHINA GROWTH PORTFOLIO seeks to provide long-term capital appreciation
     by investing primarily in equity securities of issuers in The People's
     Republic of China, Hong Kong and Taiwan.
 
    -The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of European issuers.
 
    -The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income and
     long-term capital appreciation by investing primarily in equity securities
     of companies in the European real estate industry.
 
    -The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers throughout the world,
     including U.S. issuers.
 
                                       8
<PAGE>
    -The GOLD PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of foreign and domestic issuers engaged in
     gold-related activities.
 
    -The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers.
 
    -The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers domiciled in
     EAFE countries.
 
    -The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
     by investing primarily in equity securities of non-U.S. issuers with equity
     market capitalizations of less than $1 billion.
 
    -The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Japanese issuers.
 
    U.S. EQUITY:
 
    -The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by investing
     primarily in corporate equity and equity-linked securities.
 
    -The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing primarily in growth-oriented equity securities of small- to
     medium-sized corporations.
 
    -The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing in growth-oriented equity securities of medium and large
     capitalization companies.
 
    -The MICROCAP PORTFOLIO seeks long-term capital appreciation by investing
     primarily in growth-oriented equity securities of small corporations.
 
    -The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total return by
     investing in equity securities of small- to medium-sized companies which
     the Adviser believes to be undervalued.
 
    -The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of companies that, in the opinion of the
     Adviser, are expected to benefit from their involvement in technology and
     technology-related industries.
 
    -The U.S. EQUITY PLUS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers included in the S&P 500
     Index ("S&P 500").
 
    -The U.S. REAL ESTATE PORTFOLIO seeks to provide above average current
     income and long-term capital appreciation by investing primarily in equity
     securities of companies in the U.S. real estate industry, including
     substantial investment in real estate investment trusts.
 
    -The VALUE EQUITY PORTFOLIO seeks high total return by investing in equity
     securities which the Adviser believes to be undervalued relative to the
     stock market in general at the time of purchase.
 
    BALANCED:
 
    -The BALANCED PORTFOLIO seeks high total return while preserving capital by
     investing in a combination of equity securities which the Adviser believes
     to be undervalued and fixed income securities.
 
                                       9
<PAGE>
    FIXED INCOME:
 
    -The FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
     with the preservation of capital by investing in a diversified portfolio of
     fixed income securities.
 
    -The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
     of return while preserving capital by investing in fixed income securities
     of issuers throughout the world, including U.S. issuers.
 
    -The HIGH YIELD PORTFOLIO seeks to maximize total return by investing in a
     diversified portfolio of high yield fixed income securities that offer a
     yield above that generally available on debt securities in the four highest
     rating categories of the recognized rating services.
 
    -The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a level
     of current income as is consistent with the preservation of capital by
     investing primarily in a variety of investment grade mortgage-backed
     securities.
 
    -The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of current
     income consistent with preservation of principal by investing in municipal
     obligations, the interest on which is exempt from federal income tax.
 
    MONEY MARKET:
 
    -The MONEY MARKET PORTFOLIO seeks to maximize current income and preserve
     capital while maintaining high levels of liquidity through investing in
     high quality money market instruments with remaining maturities of one year
     or less.
 
    -The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current tax-exempt
     income and preserve capital while maintaining high levels of liquidity
     through investing in high quality money market instruments with remaining
     maturities of one year or less which are exempt from federal income tax.
 
    THE CHINA GROWTH, GOLD, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS
    ARE CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley Dean Witter & Co., acts as investment adviser to the Fund and each of
its portfolios. As of March 31, 1998, Morgan Stanley Asset Management Inc. and
its affiliated institutional asset management companies managed assets of
approximately $166 billion, including assets under fiduciary advice. See
"Management of the Fund -- Investment Adviser" and "Management of the Fund --
Administrator."
 
HOW TO INVEST
 
    Class A shares of each Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of each
Portfolio are offered at net asset value with no sales commission, but with a
12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25% of the
Class B shares' average daily net assets on an annualized basis. The minimum
initial investment, generally, is $500,000 for Class A shares of each Portfolio
and $100,000 for Class B shares of each Portfolio. The minimum initial
investment amount is reduced for certain categories of investors. For additional
information on how to purchase shares and minimum initial investments, see
"Purchase of Shares."
 
                                       10
<PAGE>
HOW TO REDEEM
 
    Class A shares or Class B shares of each Portfolio may be redeemed at any
time, without cost, at the net asset value per share of the applicable class
next determined after receipt of the redemption request. The redemption price
may be more or less than the purchase price. Certain redemptions that cause the
value of an account to remain for a continuous 60-day period below the minimum
investment amount for Class A shares or for Class B shares may result in
involuntary redemption or conversion. For additional information on how to
redeem shares and involuntary redemption or conversion, see "Purchase of Shares"
and "Redemption of Shares."
 
RISK FACTORS
 
    Investing in each of the Portfolios entails certain risks and considerations
of which an investor should be aware. The Portfolios' share prices and
investment returns fluctuate and, when redeemed, an investment in the Portfolios
may be worth more or less than its original cost. The investment policies of the
Portfolios may entail the following risk factors:
 
    -EQUITY SECURITIES. The Emerging Markets and Latin American Portfolios may
     invest in equity securities. Prices of equity securities fluctuate in
     response to many factors, including the financial health of the issuers and
     changes in economic and market conditions.
 
    -FIXED INCOME SECURITIES. Each Portfolio will be subject to credit risk and
     market risk associated with investment in fixed income securities. Credit
     risk is the possibility that an issuer may be unable to meet scheduled
     principal and interest payments. Market risk is the possibility that a
     change in interest rates or the market's perception of the issuer's
     prospects may adversely affect the value of a fixed income security.
 
    -HIGH YIELD SECURITIES. Each Portfolio may invest in lower rated and unrated
     fixed income securities (i.e., high yield or high risk securities), which
     are often issued by smaller or less creditworthy companies. High yield
     securities generally are subject to greater market risk and credit risk
     than other fixed income securities.
 
    -FOREIGN INVESTMENT. Each Portfolio may invest in the securities of foreign
     issuers. The risks of foreign investment include fluctuations in foreign
     currency values, political events affecting the country of issuance and
     potentially greater market volatility and lower liquidity.
 
    -EMERGING MARKET COUNTRY SECURITIES. Each Portfolio may invest in emerging
     market country securities which entail risks typically associated with
     investment in more established foreign markets. However, these risks may be
     intensified due to higher volatility and less liquidity of emerging
     markets, possible political risks associated with the country of issuance
     and generally weaker financial condition of issuers in these markets.
 
    -DERIVATIVES. Each Portfolio may invest in instruments that derive their
     values from those of specified securities, indices, currencies or other
     points of reference. These derivatives, including those used to manage
     risk, are themselves subject to the risks of the different markets in which
     they are traded and, therefore, may or may not serve their intended
     purposes.
 
For additional information about risk factors, see also "Investment Objectives
and Policies" and "Additional Investment Information."
 
                                       11
<PAGE>
                       INVESTMENT OBJECTIVES AND POLICIES
 
    The investment objective of each Portfolio is described below, together with
the policies each Portfolio will employ in its efforts to achieve its objective.
Each Portfolio's investment objective is a fundamental policy which may not be
changed without the approval of a majority of the Portfolio's outstanding voting
securities. There is no assurance that the Portfolios will attain their
objectives. In addition to the investments and strategies described below, the
Portfolios may invest in certain securities and obligations as set forth in
"Additional Investment Information" and as described under "Investment
Objectives and Policies" in the Statement of Additional Information. The
investment policies described below are not fundamental policies unless
otherwise noted and may be changed without shareholder approval.
 
THE EMERGING MARKETS PORTFOLIO
 
    The investment objective of the Portfolio is to provide long-term capital
appreciation by investing primarily in equity securities of emerging country
issuers. With respect to the Portfolio, equity securities include common and
preferred stocks, convertible securities and rights and warrants to purchase
common stocks. The Portfolio may also invest indirectly in equity securities of
emerging country issuers through depositary receipts. Under normal
circumstances, at least 65% of the Portfolio's total assets will be invested in
emerging country equity securities. An emerging country security is one issued
by a company that, in the opinion of the Adviser, has one or more of the
following characteristics: (i) its principal securities trading market is in an
emerging country, (ii) alone, or on a consolidated basis, the company derives
50% or more of its annual revenue from either goods produced, sales made or
services performed in emerging countries; or (iii) the company is organized
under the laws of, and has a principal office in, an emerging country. The
Adviser will base determinations as to eligibility on publicly available
information and inquiries made to the companies. Currently, investing in many
emerging countries is not feasible or may involve unacceptable political risks.
The Portfolio will focus its investments on those emerging market countries in
which it believes the economies are developing strongly and in which the markets
are becoming more sophisticated. The Portfolio intends to invest primarily in
some or all of the following countries:
 
<TABLE>
<S>                     <C>                     <C>                     <C>
Argentina               Ghana                   Korea                   Singapore
Botswana                Greece                  Malaysia                South Africa
Brazil                  Hong Kong               Mexico                  South Korea
Bulgaria                Hungary                 Morocco                 Sri Lanka
Chile                   India                   Nigeria                 Taiwan
China                   Indonesia               Pakistan                Thailand
(mainland and Hong      Israel                  Peru                    Turkey
Kong)                   Jamaica                 Philippines             Venezuela
Colombia                Jordan                  Poland                  Zimbabwe
Egypt                   Kenya                   Russia
</TABLE>
 
As markets in other countries develop, the Portfolio expects to expand and
further diversify the emerging countries in which it invests. The Portfolio does
not intend to invest in any security in a country where the currency is not
freely convertible to U.S. dollars, unless the Portfolio has obtained the
necessary governmental licensing to convert such currency or other appropriately
licensed or sanctioned contractual guarantees to
 
                                       12
<PAGE>
protect such investment against loss of that currency's external value, or the
Portfolio has a reasonable expectation at the time the investment is made that
such governmental licensing or other appropriately licensed or sanctioned
guarantees would be obtained or that the currency in which the security is
quoted would be freely convertible at the time of any proposed sale of the
security by the Portfolio.
 
    To the extent that the Portfolio's assets are not invested in emerging
country equity securities, the remainder of the assets may be invested in (i)
debt securities denominated in the currency of an emerging country or issued or
guaranteed by an emerging country company or the government of an emerging
country; (ii) equity or debt securities of corporate or governmental issuers
located in industrialized countries; and (iii) short- and medium-term debt
securities. The Portfolio's assets may be invested in debt securities when the
Portfolio believes that, based upon factors such as relative interest rate
levels and foreign exchange rates, such debt securities offer opportunities for
long-term capital appreciation. It is likely that many of the debt securities in
which the Portfolio will invest will be unrated and, whether or not rated, such
securities may have speculative characteristics. When deemed appropriate by the
Adviser, the Portfolio may invest up to 20% of its total assets (measured at the
time of the investment) in high yield securities.
 
THE EMERGING MARKETS DEBT PORTFOLIO
 
    The investment objective of the Portfolio is to seek high total return. In
seeking to achieve this objective, the Portfolio will seek to invest at least
65% of its total assets in debt securities of government and government-related
issuers located in emerging countries (including participations in loans between
governments and financial institutions), and of entities organized to
restructure outstanding debt of such issuers. In addition, the Portfolio may
invest up to 35% of its total assets in debt securities of corporate issuers
located in or organized under the laws of emerging countries.
 
    The Adviser intends to invest the Portfolio's assets in emerging country
debt securities that provide a high level of current income, while at the same
time holding the potential for capital appreciation if the perceived
creditworthiness of the issuer improves due to improving economic, financial,
political, social or other conditions in the country in which the issuer is
located. Emerging country debt securities that the Portfolio may invest in
include bonds, notes, bills, debentures, convertible securities, warrants, bank
debt obligations, short-term paper, mortgage and other asset-backed securities,
loan participations, loan assignments and interests issued by entities organized
and operated for the purpose of restructuring the investment characteristics of
instruments
 
                                       13
<PAGE>
issued by emerging country issuers. Currently, investing in many emerging
country securities is not feasible or may involve unacceptable political risks.
Initially, the Portfolio expects that its investments in emerging country debt
securities will be made primarily in some or all of the following emerging
countries:
 
<TABLE>
<S>                     <C>                     <C>
Algeria                 Hungary                 Peru
Argentina               India                   Philippines
Brazil                  Indonesia               Poland
Bulgaria                Ivory Coast             Russia
Chile                   Jamaica                 Slovakia
China                   Jordan                  South Africa
Colombia                Malaysia                Thailand
Costa Rica              Mexico                  Trinidad & Tobago
Czech Republic          Morocco                 Tunisia
Democratic Republic of
Congo                   Nicaragua               Turkey
Dominican Republic      Nigeria                 Uruguay
Ecuador                 Pakistan                Venezuela
Egypt                   Panama
Greece                  Paraguay
</TABLE>
 
As opportunities to invest in debt securities in other countries develop, the
Portfolio expects to expand and further diversify the emerging countries in
which it invests. While the Portfolio generally is not restricted in the portion
of its assets which may be invested in a single country or region, it is
anticipated that, under normal conditions, the Portfolio's assets will be
invested in issuers in at least three countries.
 
    U.S. dollar-denominated emerging country debt securities held by the
Portfolio will generally be listed but not traded on a securities exchange, and
non-U.S. dollar-denominated securities held by the Portfolio may or may not be
listed or traded on a securities exchange. The Portfolio is not restricted in
the portion of its assets which may be invested in securities denominated in a
particular currency and a substantial portion of the Portfolio's assets may be
invested in non-U.S. dollar-denominated securities. The portion of the
Portfolio's assets invested in securities denominated in currencies other than
the U.S. dollar will vary depending on market conditions. The Portfolio will be
subject to no restrictions on the maturities of the emerging country debt
securities it holds; those maturities may range from overnight to 30 years. The
Portfolio may also invest up to 5% of its total assets in mortgage-backed
securities and in other asset-backed securities issued by non-governmental
entities, such as banks and other financial institutions.
 
    In selecting particular emerging country debt securities for investment by
the Portfolio, the Adviser will apply a market risk analysis contemplating
factors such as liquidity, volatility, tax consequences, interest rate
sensitivity, counterparty risks and technical market considerations. Emerging
country debt securities in which the Portfolio may invest will not be required
to meet a minimum rating standard and may not be rated for creditworthiness by
any internationally recognized credit rating organization. The Portfolio's
investments are expected to be rated in the lower and lowest rating categories
of internationally recognized credit rating organizations or, if unrated, of
comparable quality. These types of debt obligations are predominantly
speculative with respect to the capacity to pay interest and repay principal in
accordance with their terms and generally
 
                                       14
<PAGE>
involve a greater risk of default and of volatility in price than securities in
higher rating categories. Ratings of non-U.S. debt instruments, to the extent
undertaken, are related to evaluations of the country in which the issuer of the
instrument is located and generally take into account the currency in which a
non-U.S. debt instrument is denominated. Instruments issued by a foreign
government in other than the local currency, typically have a lower rating than
local currency instruments due to the risk that the government will be unable to
obtain the required foreign currency to service its foreign currency-denominated
debt. In general, the ratings of debt securities or obligations issued by a
non-U.S. public or private entity will not be higher than the rating of the
currency or the foreign currency debt of the central government of the country
in which the issuer is located, regardless of the intrinsic creditworthiness of
the issuer.
 
    The Portfolio's investments in government, government-related and
restructured debt securities will consist of (i) debt securities or obligations
issued or guaranteed by governments, governmental agencies or instrumentalities
and political subdivisions located in emerging countries including
participations in loans between governments and financial institutions; (ii)
debt securities or obligations issued by government owned, controlled or
sponsored entities located in emerging countries; (iii) fixed income securities
known as "Brady Bonds"; and (iv) issuers of structured securities. Certain
issuers of such structured securities may be deemed to be "investment companies"
as defined in the Investment Company Act of 1940, as amended (the "1940 Act").
As a result, the Portfolio's investment in such securities may be limited by
certain investment restrictions contained in the 1940 Act. The Portfolio's
investments in government, government-related and restructured debt instruments
are subject to special risks, including the inability or unwillingness to repay
principal and interest, requests to reschedule or restructure outstanding debt
and requests to extend additional loan amounts. The Portfolio may have limited
recourse in the event of default on such debt instruments. The Portfolio's
investments in debt securities of corporate issuers in emerging countries may
include debt securities or obligations issued (i) by banks located in emerging
countries or by branches of emerging country banks located outside the country,
or (ii) by companies organized under the laws of an emerging country.
Determinations as to eligibility will be made by the Adviser based on publicly
available information and inquiries made to the issuer.
 
    The table below provides a summary of ratings assigned by Standard & Poor's
Ratings Group ("S&P") to debt obligations in the Emerging Markets Debt
Portfolio. These figures are dollar-weighted averages of month-
 
                                       15
<PAGE>
end portfolio holdings during the fiscal year ended December 31, 1997, presented
as a percentage of total investments. These percentages are historical and are
not necessarily indicative of the quality of current or future portfolio
holdings, which may vary.
 
<TABLE>
<CAPTION>
      S&P
- ----------------
         AVERAGE
         PERCENT
           OF
         PORTFOLIO
RATING   HOLDINGS
- -------  -------
<S>      <C>
AAA      0.00%
AA       0.00%
A        0.00%
BBB      0.74%
BB       65.83%
B        27.37%
CCC      0.00%
CC       0.00%
Unrated  6.06%
</TABLE>
 
THE LATIN AMERICAN PORTFOLIO
 
    The investment objective of the Latin American Portfolio is long-term
capital appreciation. The Portfolio seeks to achieve this objective by investing
primarily in equity securities (i) of companies organized in or for which the
principal securities trading market is in Latin America; (ii) denominated in a
Latin American currency and issued by companies to finance operations in Latin
America; or (iii) of companies that alone or on a consolidated basis derive 50%
or more of their annual revenues from either goods produced, sales made or
services performed in Latin America (collectively, "Latin American issuers") and
by investing, from time to time, in debt securities issued or guaranteed by a
Latin American government or governmental entity. Under normal circumstances,
substantially all, but not less than 80%, of the Portfolio's total assets are
invested in equity securities of Latin American issuers and in debt securities
issued or guaranteed by a Latin American government or governmental entity. For
purposes of this Prospectus, unless otherwise indicated, Latin America consists
of Argentina, Bolivia, Brazil, Chile, Colombia, Costa Rica, Cuba, the Dominican
Republic, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama,
Paraguay, Peru, Uruguay and Venezuela.
 
    The Portfolio focuses its investments in listed equity securities in
Argentina, Brazil, Chile and Mexico, the most developed capital markets in Latin
America. The Portfolio expects, under normal circumstances, to have at least 55%
of its total assets invested in listed equity securities of issuers in these
four countries. The Portfolio is not limited in the extent to which it may
invest in any Latin American country and intends to invest opportunistically as
markets develop. The portion of the Portfolio's holdings in any Latin American
country will vary from time to time, although the portion of the Portfolio's
assets invested in Chile may tend to vary less than the portions invested in
other Latin American countries because, with limited exceptions, capital
invested in Chile currently cannot be repatriated for one year. Equity
securities in which the Portfolio may invest include those that are neither
listed on a stock exchange nor traded over-the-counter. As a result of the
absence of a public trading market for these securities, they may be less liquid
than publicly traded securities.
 
                                       16
<PAGE>
    The governments of some Latin American countries have been engaged in
programs of selling part or all of their stakes in government owned or
controlled enterprises ("privatizations"). The Adviser believes that
privatizations may offer investors opportunities for significant capital
appreciation and intends to invest assets of the Portfolio in privatizations in
appropriate circumstances. In certain Latin American countries, the ability of
foreign entities, such as the Portfolio, to participate in privatizations may be
limited by local law, or the terms on which the Portfolio may be permitted to
participate may be less advantageous than those for local investors. There can
be no assurance that Latin American governments will continue to sell companies
currently owned or controlled by them or that any privatization programs in
which the Portfolio participates will be successful.
 
    The Portfolio also may participate in debt to equity conversion programs
adopted by several Latin American countries, pursuant to which investors may use
government issued or guaranteed debt securities, directly or indirectly, to make
investments in local companies. The terms of the various programs vary from
country to country although each program includes significant restrictions on
the application of the proceeds received in the conversion and on the remittance
of profits on the investment and of the invested capital. The Adviser will
evaluate opportunities to enter into debt to equity conversion transactions as
they arise.
 
    To the extent that the Portfolio's assets are not invested in equity
securities of Latin American issuers or in government issued or guaranteed debt
securities, the remainder of its assets may be invested in (i) debt securities
of other Latin American issuers; (ii) equity or debt securities of corporate or
governmental issuers located in countries outside Latin America; and (iii)
short-term and medium-term debt securities. The Portfolio's assets may be
invested in debt securities when the Portfolio believes that, based upon factors
such as relative interest rate levels and foreign exchange rates, debt
securities offer opportunities for long-term capital appreciation. It is likely
that many of the debt securities in which the Portfolio will invest will be
unrated. The Portfolio may invest up to 20% of its total assets in lower-quality
debt securities that are determined by the Adviser to be comparable to
securities rated below investment grade by S&P or Moody's Investors Service,
Inc. ("Moody's") ("junk bonds"). Investment in such debt securities involves a
high degree of risk and is generally considered to be speculative in nature.
 
    The Portfolio will not invest more than 25% of its total assets in one
industry, except to the extent and only for such period of time as the Board of
Directors determines that it is appropriate and in the best interests of the
Portfolio and its shareholders to invest more than 25% of the Portfolio's total
assets in companies involved in each of the telecommunications or financial
services industries. Concentration in these two industries may be beneficial to
the Portfolio because the securities markets of Latin American countries are
emerging markets characterized by a relatively small number of issuers and it is
possible that one or more markets may be dominated by issues of companies in
these industries. Also, it is possible that privatizations in certain Latin
American countries, which currently represent a primary source of new issues in
many Latin American markets and which are often attractive investment
opportunities, will occur in these two industries.
 
    The Board of Directors has determined that, in light of the increased
presence of telecommunications companies in the Latin American markets, the
Portfolio's ability to achieve its investment objective would be materially
adversely affected if it were not permitted to invest more than 25% of its
assets in securities of companies in the telecommunications industries of the
Latin American countries in which the Portfolio invests. In accordance with the
Portfolio's investment restrictions and as a result of the Board's action, the
Portfolio is
 
                                       17
<PAGE>
required to invest at least 25% of its total assets in securities of Latin
American issuers engaged in the telecommunications industry. The Portfolio will
remain so invested until the Board determines that the Portfolio should invest
less than 25% of its assets in that industry. Because the Portfolio will have a
more concentrated position in the securities of a single sector within the Latin
American securities markets, the Portfolio will be subject to certain risks with
respect to these portfolio securities. Market price movements affecting
telecommunications companies and their securities will have a greater impact on
the Portfolio's performance because of the more concentrated position in such
securities. Telecommunications may be subject to greater government regulation
than many other industries. Changes in government policies and the need to
obtain regulatory approvals may have a material effect on products and services
offered by telecommunications companies. Technological and structural
developments may adversely affect the profitability of telecommunications
companies. To better control the Portfolio's exposure to such risks, the Board
has limited investments in telecommunications securities to not more than 40% of
the Portfolio's assets.
 
    The Board of Directors has not currently authorized the Portfolio to invest
more than 25% of its total assets in the financial services industry. The
Portfolio will notify shareholders of any decision by the Board of Directors to
permit investments of more than 25% in the financial services industry
including, if applicable, a discussion of any increased investment risks
particular to this industry to which the Portfolio may be exposed.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    BORROWING AND OTHER FORMS OF LEVERAGE.  The Emerging Markets Debt and Latin
American Portfolios are authorized to borrow money from banks and other entities
in an amount up to 33 1/3% of the Portfolios' total assets (including the amount
borrowed) less all liabilities and indebtedness other than the borrowing, and
may use the proceeds of the borrowing for investment purposes or to pay
dividends. Borrowing for investment purposes creates leverage which is a
speculative characteristic. Borrowing by the Portfolios will create the
opportunity for increased net income but, at the same time, will involve special
risk considerations. Leverage that results from borrowing will magnify declines
as well as increases in the Portfolios' net asset value per share and net yield.
Although the Portfolios are authorized to borrow, they will do so only when the
Adviser believes that borrowing will benefit the Portfolios after taking into
account considerations such as the costs of the borrowing and the likely
investment returns on securities purchased with borrowed funds.
 
    The Portfolios expect that all of their borrowing will be made on a secured
basis. The Portfolios' Custodian will either segregate the assets securing the
borrowing for the benefit of the lenders or arrangements will be made with a
suitable sub-custodian. If assets used to secure the borrowing decrease in
value, the Portfolios may be required to pledge additional collateral to the
lender in the form of cash or securities to avoid liquidation of those assets.
 
    BRADY BONDS.  Brady Bonds are fixed income securities that are created
through the exchange of existing commercial bank loans to foreign entities for
new obligations in connection with debt restructuring. Brady Bonds have been
issued only in recent years and, accordingly, do not have a long payment
history. They may be collateralized or uncollateralized and issued in various
currencies (although most are U.S. dollar-denominated)
 
                                       18
<PAGE>
and they are actively traded in the over-the-counter secondary market.
Investment in Brady Bonds should be viewed as speculative in light of the
history of defaults with respect to commercial bank loans by public and private
entities of countries issuing Brady Bonds.
 
    DEPOSITARY RECEIPTS.  The Portfolios may invest in Depositary Receipts,
including American Depositary Receipts ("ADRs"), Global Depositary Receipts
("GDRs"), European Depositary Receipts ("EDRs") and other Depositary Receipts
(which, together with ADRs, GDRs and EDRs, are hereinafter collectively referred
to as "Depositary Receipts"), to the extent that such Depositary Receipts are or
become available. ADRs are securities, typically issued by a U.S. financial
institution (a "depositary"), that evidence ownership interests in a security or
a pool of securities issued by a foreign issuer (the "underlying issuer") and
deposited with the depositary. ADRs may be "sponsored" or "unsponsored."
Sponsored ADRs are established jointly by a depositary and the underlying
issuer, whereas unsponsored ADRs may be established by a depositary without
participation by the underlying issuer. The issuers of the stock of unsponsored
ADRs are not obligated to disclose material information in the United States and
therefore, there may not be a correlation between such information and the
market value of the ADR. GDRs, EDRs and other types of Depositary Receipts are
typically issued by foreign depositaries, although they may also be issued by
U.S. depositaries, and evidence ownership interests in a security or pool of
securities issued by either a foreign or a U.S. corporation. Generally,
Depositary Receipts in registered form are designed for use in the U.S.
securities market and Depositary Receipts in bearer form are designed for use in
securities markets outside the United States. The Portfolios may invest in
sponsored and unsponsored Depositary Receipts. For purposes of the Portfolios'
investment policies, the Portfolios' investments in Depositary Receipts will be
deemed to be investments in the underlying securities.
 
    FIXED INCOME SECURITIES.  Each Portfolio will invest in fixed income (debt)
securities. The market value of the fixed income securities in which a Portfolio
invests will be affected by changes in the creditworthiness of issuers and will
change in response to interest rate changes and other factors. Generally, the
values of fixed income securities vary inversely with changes in interest rates,
so that during periods of falling interest rates, the values of outstanding
fixed income securities generally rise and during periods of rising interest
rates, the values of such securities generally decline. While securities with
longer maturities tend to produce higher yields, the prices of longer maturity
securities are subject to greater market fluctuations as a result of changes in
interest rates.
 
    FOREIGN CURRENCY FORWARD CONTRACTS.  The Portfolios may enter into foreign
currency forward contracts ("forward contracts") that provide for the purchase
or sale of an amount of a specified currency at a future date. The Portfolios
may use such contracts to protect against a decline in a foreign currency
against the U.S. dollar between the trade date and settlement date when the
Portfolio purchases or sells securities, lock in the U.S. dollar value of
dividends and interest on securities held by the Portfolio, and generally to
protect the U.S. dollar value of securities held by the Portfolio against
exchange rate fluctuation. While forward contracts may limit losses as a result
of exchange rate fluctuations, they will also limit any gains that might
otherwise have been realized. The Portfolio's Custodian may be required to place
cash or liquid securities in a segregated account in an amount equal to the
value of the Portfolio's total assets committed to the consummation of forward
contracts. If the value of the securities placed in the segregated account
declines, additional cash or securities will be placed in the account on a daily
basis so that the value of the account will be at least equal to the amount of
the Portfolio's commitments with respect to such contracts.
 
                                       19
<PAGE>
    FOREIGN INVESTMENT.  Each Portfolio will invest in the securities of foreign
issuers. Investment in securities of foreign issuers involves investment risks
somewhat different from those affecting securities of U.S. issuers. The
Portfolio's investments will be subject to political and economic events that
affect the countries in which it invests. Foreign issuers may be subject to
different accounting, auditing and financial standards and requirements. There
also may be less government supervision and regulation of foreign securities
exchanges, brokers and listed companies than in the United States. Many foreign
securities markets have substantially less trading volume than U.S. national
securities exchanges and, therefore, securities of some foreign issuers are less
liquid and more volatile than securities of comparable U.S. issuers. Brokerage
commissions and other transaction costs on foreign securities exchanges are
generally higher than in the United States. Dividends and interest paid by
foreign issuers may be subject to withholding and other foreign taxes, which may
decrease the net return on foreign investments as compared to dividends and
interest paid to the Portfolios by domestic companies. Investments in securities
of foreign issuers are generally denominated in foreign currencies and, since a
Portfolio may temporarily hold uninvested reserves in bank deposits in foreign
currencies, the value of a Portfolio's assets as measured in U.S. dollars may be
affected favorably or unfavorably by changes in currency exchange rates and
exchange control regulations, and a Portfolio may incur costs in connection with
conversions between various currencies.
 
    The Portfolios will also invest in emerging market country securities.
Investing in emerging markets entails the risks associated with foreign
investment described above, however, these risks may be intensified in emerging
markets. Emerging markets can include every nation in the world except the
United States, Canada, Japan, Australia, New Zealand and most nations located in
Western Europe. Certain emerging market countries have historically experienced,
and may continue to experience, high rates of inflation, high interest rates,
exchange rate fluctuations, large amounts of external debt, trade difficulties
and unemployment. Further, the economies of developing countries generally are
heavily dependent upon international trade and, accordingly, have been, and may
continue to be, adversely affected by trade barriers, exchange controls and
other protectionist measures imposed or negotiated by the countries in which
they trade. There also are risks associated with the possibility of
nationalization, expropriation or confiscatory taxation, political changes,
government regulation, social instability or diplomatic developments (including
war) that could adversely affect the economies of such countries or the value of
a Portfolio's investments in those countries.
 
    HIGH YIELD SECURITIES.  Each Portfolio may invest in lower rated or unrated
debt securities, commonly referred to as high yield, high risk securities or
"junk bonds". High yield securities are debt securities rated below the four
highest rating categories (i.e., Ba through C by Moody's or BB through D by S&P)
and unrated securities considered to be of equivalent quality by the Adviser.
Such securities carry a high degree of risk and are considered speculative by
the major credit rating agencies.
 
    While such securities offer high yields, they also normally carry with them
a greater degree of risk than securities with higher ratings. The values of high
yield securities are more volatile and may react with greater sensitivity to
market changes. Also, high yield securities are often issued by smaller, less
creditworthy companies, or by highly leveraged (indebted) companies, which are
generally less able than more established or less leveraged companies to make
scheduled payments of interest and principal. The price movement of these
securities is influenced less by changes in interest rates and more by the
financial position of the issuing corporation.
 
                                       20
<PAGE>
    INVESTMENT FUNDS.  Some emerging countries have laws and regulations that
currently preclude direct foreign investment in the securities of their
companies. However, indirect foreign investment in the securities of companies
listed and traded on the stock exchanges in these countries is permitted by
certain emerging countries through investment funds which have been specifically
authorized. The Portfolios may invest in these investment funds subject to the
provisions of the 1940 Act and other applicable laws as discussed below under
"Investment Restrictions." If a Portfolio invests in such investment funds, the
Portfolio's shareholders will bear not only their proportionate share of the
expenses of the Portfolio (including operating expenses and the fees of the
Adviser), but also will indirectly bear similar expenses of the underlying
investment funds.
 
    Certain of the investment funds referred to in the preceding paragraph are
advised by the Adviser. These Portfolios may, to the extent permitted under the
1940 Act and other applicable law, invest in these investment funds. If a
Portfolio does elect to make an investment in such an investment fund, it will
only purchase the securities of such investment fund in the secondary market.
 
    LOAN PARTICIPATIONS AND ASSIGNMENTS.  The Portfolios may invest in fixed
rate and floating rate loans ("Loans") arranged through private negotiations
between an issuer of sovereign debt obligations and one or more financial
institutions ("Lenders"). The Portfolios' investments in Loans are expected in
most instances to be in the form of participation in Loans ("Participations")
and assignments of all or a portion of Loans ("Assignments") from third parties.
The Portfolios will have the right to receive payments of principal, interest
and any fees to which it is entitled only from the Lender selling the
Participation and only upon receipt by the Lender of the payments from the
borrower. In the event of the insolvency of the Lender selling a Participation,
the Portfolios may be treated as a general creditor of the Lender and may not
benefit from any set-off between the Lender and the borrower. Certain
Participations may be structured in a manner designed to avoid purchasers of
Participations being subject to the credit risk of the Lender with respect to
the Participation. Even under such a structure, in the event of the Lender's
insolvency, the Lender's servicing of the Participation may be delayed and the
assignability of the Participation may be impaired. The Portfolios will acquire
Participations only if the Lender interpositioned between the Portfolios and the
borrower is determined by the Adviser to be creditworthy.
 
    When the Portfolios purchase Assignments from Lenders they will acquire
direct rights against the borrower on the Loan. However, because Assignments are
arranged through private negotiations between potential assignees and potential
assignors, the rights and obligations acquired by the Portfolios as the
purchaser of an Assignment may differ from, and be more limited than, those held
by the assigning Lender. Because there is no liquid market for such securities,
the Portfolios anticipate that such securities could be sold only to a limited
number of institutional investors. The lack of a liquid secondary market may
have an adverse impact on the value of such securities and the Portfolios'
ability to dispose of particular Assignments or Participations when
necessary to meet the Portfolios' liquidity needs or in response to a specific
economic event such as a deterioration in the creditworthiness of the borrower.
The lack of a liquid secondary market for Assignments and Participations also
may make it more difficult for the Portfolios to assign a value to these
securities for purposes of valuing the Portfolios' portfolio and calculating
their net asset value.
 
    LOANS OF PORTFOLIO SECURITIES.  The Portfolios may lend securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing net investment income. These loans must be secured
continuously by cash or equivalent collateral, or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be a risk of delay in recovery of the
 
                                       21
<PAGE>
securities or even loss of rights in the collateral should the borrower of the
securities fail financially. Each Portfolio will not enter into securities loan
transactions exceeding in the aggregate 33 1/3% of the market value of its total
assets.
 
    MONEY MARKET INSTRUMENTS.  Each Portfolio is permitted to invest in money
market instruments, although each Portfolio intends to stay invested in
securities satisfying its primary investment objective to the extent practical.
Consistent with their investment policies, the Portfolios may make money market
investments pending other investment or settlement for liquidity. In addition,
the Portfolios may invest in money market instruments for temporary, defensive
purposes during adverse market conditions. The money market investments
permitted for the Portfolios include: obligations of the U.S. government and its
agencies and instrumentalities, obligations of foreign sovereignties, commercial
paper, bank obligations (including certificates of deposit), other debt
securities and repurchase agreements.
 
    NON-PUBLICLY TRADED SECURITIES, PRIVATE PLACEMENTS AND RESTRICTED
SECURITIES.  The Portfolios may invest in securities that are neither listed on
a stock exchange nor traded over-the-counter, including privately placed
securities. Investing in such unlisted securities, including investments in new
and early stage companies, may involve a high degree of business and financial
risk that can result in substantial losses. As a result of the absence of a
public trading market for these securities, they may be less liquid than
publicly traded securities. Although these securities may be resold in privately
negotiated transactions, the prices realized from these sales could be less than
those originally paid by the Portfolios or less than what may be considered the
fair value of such securities. Further, companies whose securities are not
publicly traded may not be subject to the disclosure and other investor
protection requirements which might be applicable if their securities were
publicly traded. If such securities are required to be registered under the
securities laws of one or more jurisdictions before being resold, the Portfolios
may be required to bear the expenses of registration.
 
    As a general matter, each Portfolio may not invest more than 15% of its net
assets in illiquid securities, including securities for which there is no
readily available secondary market. Also, as a general matter, each Portfolio
may not invest more than 10% of its total assets in securities that are
restricted from sale to the public without registration ("Restricted
Securities") under the Securities Act of 1933 (the "1933 Act"). However, each
Portfolio may invest up to 25% of its total assets in liquid Restricted
Securities that can be offered and sold to qualified institutional buyers under
Rule 144A under the 1933 Act ("Rule 144A Securities"). The Board of Directors
has adopted guidelines and delegated to the Adviser, subject to the supervision
of the Board of Directors, the daily function of determining and monitoring the
liquidity of Rule 144A Securities. Rule 144A securities may become illiquid if
qualified institutional buyers are not interested in acquiring the securities.
 
    REPURCHASE AGREEMENTS.  Each Portfolio may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines established by
the Fund's Board of Directors. In a repurchase agreement, the Portfolio buys a
security from a seller that has agreed to repurchase it at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of the
agreement. The term of these agreements is usually from overnight to one week,
and never exceeds one year. A repurchase agreement may be viewed as a fully
collateralized loan of money by the Portfolio to the seller. The Portfolio
always receives securities with a market value at least equal to the purchase
price (including accrued interest) as collateral, and this value is maintained
during the term of the agreement. If the seller defaults and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with respect to the seller, the Portfolio's realization upon the
collateral may be delayed or limited. The Portfolios may not enter into
repurchase agreements with more
 
                                       22
<PAGE>
than seven days to maturity if, as a result, more than 15% of the market value
of the Portfolio's net assets would be invested in such repurchase agreements
and in other investments for which market quotations are not readily available
or which are otherwise illiquid.
 
    REVERSE REPURCHASE AGREEMENTS.  The Emerging Markets Debt and Latin American
Portfolios may enter into reverse repurchase agreements with brokers, dealers,
domestic and foreign banks or other financial institutions. In a reverse
repurchase agreement, the Portfolio sells a security and agrees to repurchase it
at a mutually agreed upon date and price, reflecting the interest rate effective
for the term of the agreement. It may also be viewed as the borrowing of money
by the Portfolio. The Portfolio's investment of the proceeds of a reverse
repurchase agreement is the speculative factor known as leverage. The Portfolio
may enter into a reverse repurchase agreement only if the interest income from
investment of the proceeds is greater than the interest expense of the
transaction and the proceeds are invested for a period no longer than the term
of the agreement. The Portfolio will maintain with the Custodian a separate
account with a segregated portfolio of cash or other liquid securities in an
amount at least equal to its purchase obligations under these agreements.
Reverse repurchase agreements are considered to be borrowings and are subject to
the percentage limitations on borrowings set forth in "Borrowing and Other Forms
of Leverage."
 
    RUSSIAN SECURITIES TRANSACTIONS.  The Emerging Markets Portfolio may invest
in equity securities of Russian issuers. The registration, clearing and
settlement of securities transactions in Russia are subject to significant risks
not normally associated with securities transactions in the United States and
other more developed markets. Ownership of shares in Russian companies is
evidenced by entries in a company's share register (except where shares are held
through depositories that meet the requirements of the 1940 Act) and the
issuance of extracts from the register or, in certain limited cases, by formal
share certificates. However, Russian share registers are frequently unreliable
and the Portfolio could possibly lose its registration through oversight,
negligence or fraud. Moreover, Russia lacks a centralized registry to record
securities transactions and registrars located throughout Russia or the
companies themselves maintain share registers. Registrars are under no
obligation to provide extracts to potential purchasers in a timely manner or at
all and are not necessarily subject to effective state supervision. In addition,
while registrars are liable under law for losses resulting from their errors, it
may be difficult for the Portfolio to enforce any rights it may have against the
registrar or issuer of the securities in the event of loss of share
registration. Although Russian companies with more than 1,000 shareholders are
required by law to employ an independent company to maintain share registers, in
practice, such companies have not always followed this law. Because of this lack
of independence of registrars, management of a Russian company may be able to
exert considerable influence over who can purchase and sell the company's shares
by illegally instructing the registrar to refuse to record transactions on the
share register. Furthermore, these practices may prevent the Portfolio from
investing in the securities of certain Russian companies deemed suitable by the
Adviser and could cause a delay in the sale of Russian securities by the
Portfolio if the company deems a purchaser unsuitable, which may expose the
Portfolio to potential loss on its investment.
 
    In light of the risks described above, the Board of Directors of the
Portfolio has approved certain procedures concerning the Portfolio's investments
in Russian securities. Among these procedures is a requirement that the
Portfolio will not invest in the securities of Russian issuers unless that
issuer's registrar has entered into a contract with the Portfolio's
sub-custodian containing certain protective conditions including, among
 
                                       23
<PAGE>
other things, the sub-custodian's right to conduct regular share confirmations
on behalf of the Portfolio. This requirement will likely have the effect of
precluding investments in certain Russian companies that the Portfolio would
otherwise make.
 
    SHORT SALES.  The Emerging Markets Debt and Latin American Portfolios may
from time to time sell securities short without limitation, but consistent with
applicable legal requirements. A short sale is a transaction in which the
Portfolio sells securities it owns or has the right to acquire at no added cost
(i.e., "against the box") or does not own (but has borrowed) in anticipation of
a decline in the market price of the securities. To deliver the securities to
the buyer, the Portfolio arranges through a broker to borrow the securities and,
in so doing, the Portfolio becomes obligated to replace the securities borrowed
at their market price at the time of replacement. When the Portfolio makes a
short sale, the proceeds it receives from the sale will be held on behalf of a
broker until the Portfolio replaces the borrowed securities. The Portfolio may
have to pay a premium to borrow the securities and must pay any dividends or
interest payable on the securities until they are replaced.
 
    The Portfolio's obligation to replace the securities borrowed in connection
with a short sale will be secured by collateral deposited with the broker that
consists of cash or other liquid securities. In addition, the Portfolio will
place in a segregated account with its Custodian an amount of cash or other
liquid securities equal to the difference, if any, between (i) the market value
of the securities sold at the time they were sold short, and (ii) any cash or
other liquid securities deposited as collateral with the broker in connection
with the short sale. Short sales by the Portfolio involve certain risks and
special considerations. Possible losses from short sales differ from losses that
could be incurred from a purchase of a security, because losses from short sales
may be unlimited, whereas losses from purchases can equal only the total amount
invested.
 
    STRUCTURED SECURITIES.  The Emerging Markets Debt Portfolio may invest a
portion of its assets in entities organized and operated solely for the purpose
of restructuring the investment characteristics of sovereign debt obligations.
This type of restructuring involves the deposit with, or purchase by, an entity,
such as a corporation or trust, of specified instruments (such as commercial
bank loans or Brady Bonds) and the issuance by that entity of one or more
classes of securities ("Structured Securities") backed by, or representing
interests in, the underlying instruments. The cash flow on the underlying
instruments may be apportioned among the newly issued Structured Securities to
create securities with different investment characteristics, such as varying
maturities, payment priorities and interest rate provisions, and the extent of
the payments made with respect to Structured Securities is dependent on the
extent of the cash flow on the underlying instruments. Because the type of
Structured Securities in which the Portfolio anticipates it will invest
typically involve no credit enhancement, their credit risk generally will be
equivalent to that of the underlying instruments. The Portfolio is permitted to
invest in a class of Structured Securities that is either subordinated or
unsubordinated to the right of payment of another class. Subordinated Structured
Securities typically have higher yields and present greater risks than
unsubordinated Structured Securities. Certain issuers of Structured Securities
may be deemed to be "investment companies" as defined in the 1940 Act and, as a
result, the Portfolio's investment in Structured Securities may be limited by
the 1940 Act. Structured Securities are typically sold in private placement
transactions, and there currently is no active trading market for Structured
Securities.
 
    TEMPORARY INVESTMENTS.  During periods in which the Adviser believes changes
in economic, financial or political conditions make it advisable, each Portfolio
may, for temporary defensive purposes, invest up to 100% of its total assets in
certain short-term and medium-term debt obligations or hold cash. The short-term
and
 
                                       24
<PAGE>
medium-term debt obligations in which a Portfolio may invest consist of (i)
obligations of the U.S. or foreign governments, their respective agencies or
instrumentalities; (ii) money market instruments; and (iii) instruments
denominated in any currency issued by international development agencies.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  Each Portfolio may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Each Portfolio will maintain with the Custodian a
segregated account of cash or other liquid securities in an amount at least
equal to these commitments. The payment obligation and the interest rates that
will be received are each fixed at the time the Portfolio enters into the
commitment and no interest accrues to the Portfolio until settlement. Thus, it
is possible that the market value at the time of settlement could be higher or
lower than the purchase price if, among other factors, the general level of
interest rates has changed. It is a current policy of each Portfolio not to
enter into when-issued commitments or delayed delivery securities exceeding in
the aggregate 15% of the market value of the Portfolio's total assets less
liabilities, other than the obligations created by these commitments.
 
    ZERO COUPON, PAY-IN-KIND AND DEFERRED PAYMENT SECURITIES.  The Emerging
Markets Debt Portfolio may invest in zero coupon, pay-in-kind or deferred
payment securities. Zero coupon securities are securities that are sold at a
discount to par value and securities on which interest payments are not made
during the life of the security. Upon maturity, the holder is entitled to
receive the par value of the security. While interest payments are not made on
such securities, holders of such securities are deemed to have received "phantom
income" annually. Because the Portfolio will distribute its "phantom income" to
shareholders, to the extent that shareholders elect to receive dividends in cash
rather than reinvesting such dividends in additional shares of the Portfolio, it
will have fewer assets with which to purchase income producing securities. The
Portfolio accrues income with respect to these securities prior to the receipt
of cash payments. Pay-in-kind securities are securities that have interest
payable by delivery of additional securities. Upon maturity, the holder is
entitled to receive the aggregate par value of the securities. Deferred payment
securities are securities that remain zero coupon securities until a
predetermined date, at which time the stated coupon rate becomes effective and
interest becomes payable at regular intervals. Zero coupon, pay-in-kind and
deferred payment securities may be subject to greater fluctuation in value and
lesser liquidity in the event of adverse market conditions than comparably rated
securities paying cash interest at regular interest payment periods.
 
DERIVATIVE PRODUCTS (DERIVATIVES)
 
    The Portfolios are permitted to utilize various exchange-traded and
over-the-counter derivative instruments and derivative securities, both for
hedging and non-hedging purposes. Permitted derivative products include, but are
not limited to: futures contracts ("futures"); forward contracts ("forwards");
options; swaps, caps, collars and floors; structured notes; and other derivative
products yet to be developed, so long as these new products are used in a manner
consistent with the objectives of the Portfolios. These derivative products may
be based upon a wide variety of underlying rates, indices, instruments,
securities and other products, such as interest rates, foreign currencies,
foreign and domestic fixed income and equity securities, groups or "baskets" of
securities and securities indices (for each derivative product, the
"underlying"). Exclusive of forward foreign currency contracts and any
derivative products used for hedging purposes, each Portfolio will limit its use
of derivative products to 33 1/3% of its total assets, measured by the aggregate
notional amount of outstanding derivative products.
 
                                       25
<PAGE>
    The Portfolios may use derivative products under a number of different
circumstances to further their investment objectives. For example, a Portfolio
may purchase derivatives to gain exposure to a market quickly in response to
changes in the Portfolio's investment strategy, upon the inflow of investable
cash or when the derivative provides greater liquidity than the underlying
market. A Portfolio may also use derivatives when it is restricted from directly
owning the "underlying" or when derivatives provide a pricing advantage or lower
transaction costs. The Portfolios also may purchase combinations of derivatives
in order to gain exposure to an investment in lieu of actually purchasing such
investment. Derivatives may also be used by a Portfolio for hedging or risk
management purposes and in other circumstances when the Adviser believes it
advantageous to do so consistent with the Portfolio's investment objectives and
policies. The Portfolios will not use derivatives in a manner that creates
leverage, except to the extent that the use of leverage is expressly permitted
by a particular Portfolio's investment policies, and then only in a manner
consistent with such policies.
 
    The use of derivative products is a highly specialized activity which
involves investment techniques and risks different from those associated with
ordinary portfolio securities transactions. If the Adviser is incorrect in
forecasts of market values, interest rates, and currency exchange rates, the
investment performance of the Portfolios will be less favorable than it would
have been if these investment techniques had not been used.
 
    Some of the derivative products in which the Portfolios may invest and some
of the risks related thereto are described in more detail below.
 
FUTURES CONTRACTS (FUTURES) AND FORWARD CONTRACTS (FORWARDS)
 
    The Portfolios may purchase and sell futures contracts, such as futures on
securities indices, baskets of securities, foreign currencies and interest rates
of the type generally known as financial futures. These are standardized
contracts that are bought and sold on organized exchanges. A futures contract
obligates a party to buy or sell a specific amount of the "underlying," such as
for example, a particular foreign currency, on a specified future date at a
specified price or to settle the value in cash.
 
    The Portfolios may also purchase and sell forward contracts, such as forward
rate agreements and other financial forward contracts. The Portfolios may also
use foreign currency forward contracts which are separately discussed elsewhere
in this Prospectus. See "Foreign Currency Forward Contracts" above. These
forward contracts are privately negotiated and are bought and sold in the
over-the-counter market. Like a future, a forward contract obligates a party to
buy or sell a specific amount of the underlying on a specified future date at a
specified price. The terms of the forward contract are customized. Forward
contracts, like other over-the-counter contracts that are negotiated directly
with an individual counterparty, subject the Portfolio to the risk of
counterparty default.
 
    In some cases, the Portfolios may be able to use either futures contracts,
forward contracts or exchange-traded or over-the-counter options to accomplish
similar purposes. In all cases, the Portfolios will use these products only as
permitted by applicable laws and regulations. Some of the ways in which the
Portfolios may utilize futures contracts, forward contracts and related options
are as follows:
 
    The Portfolios may sell securities index futures contracts and/or index
options thereon in anticipation of or during a market decline to attempt to
offset the decrease in market value of investments in its portfolio, or may
purchase securities index futures or options in order to gain market exposure.
There currently are limited securities index futures and options on such futures
in many countries, particularly emerging countries. The
 
                                       26
<PAGE>
nature of the strategies adopted by the Adviser, and the extent to which those
strategies are used, may depend on the development of such markets. The
Portfolios may also purchase and sell foreign currency futures to hedge their
respective holdings and commitments against changes in the level of future
currency rates or to adjust their exposure to a particular currency.
 
    The Portfolios may engage in transactions in interest rate futures and
related products. The value of these contracts rises and falls inversely with
changes in interest rates. The Portfolios may engage in such transactions to
hedge their holdings of debt instruments against future changes in interest
rates or for other purposes.
 
    The Portfolios may also purchase or sell futures and forwards on other
financial instruments, such as U.S. Government securities and certificates of
deposit. The value of these contracts also rises and falls inversely with
changes in interest rates. The Portfolios may engage in financial futures and
forward contracts for both hedging and non-hedging purposes.
 
    Gains and losses on futures contracts, forward contracts and related options
depend on the Adviser's ability to predict correctly the direction of securities
prices, interest rates and other economic factors. Other risks associated with
the use of these instruments include (i) imperfect correlation between the
change in market value of investments held by a Portfolio and the prices of
derivative products relating to investments purchased or sold by the Portfolio,
and (ii) possible lack of a liquid secondary market for a derivative product and
the resulting inability to close out a position. The risk that a Portfolio will
be unable to close out a position will be minimized by only entering into
transactions for which there appears to be a liquid exchange or secondary
market. In some strategies, the risk of loss in trading on futures and related
transactions can be substantial, due both to the low margin deposits required
and the extremely high degree of leverage involved in pricing.
 
    Under rules adopted by the Commodity Futures Trading Commission (the
"CFTC"), each Portfolio may, without registering with the CFTC as a Commodity
Pool Operator, enter into futures contracts and options thereon for both hedging
and non-hedging purposes, provided that not more than 5% of such Portfolio's
total assets at the time of entering the transaction are required as margin and
option premiums to secure obligations under such contracts relating to non-bona
fide hedging activities.
 
OPTION TRANSACTIONS
 
    The Portfolios may seek to increase their returns or may hedge their
portfolio investments through options transactions with respect to individual
securities, indices or baskets in which such Portfolios may invest; other
financial instruments; and foreign currency. Various options may be purchased
and sold on either the exchange-traded or over-the-counter markets.
 
    Each Portfolio may purchase put and call options. Purchasing a put option
gives a Portfolio the right, but not the obligation, to sell the underlying
(such as a securities index or a particular foreign currency) at the exercise
price either on a specific date or during a specified exercise period.
Purchasing a call option gives a Portfolio a similar right, but not the
obligation, to purchase the underlying. The purchaser pays a premium to the
seller (also known as the writer) of the option.
 
    Each Portfolio also may write put and call options on investments held in
its portfolio, as well as foreign currency options. A Portfolio that has written
an option receives a premium that increases the Portfolio's return on the
underlying in the event the option expires unexercised or is closed out at a
profit. However, by writing a
 
                                       27
<PAGE>
call option, a Portfolio will limit its opportunity to profit from an increase
in the market value of the underlying above the exercise price of the option. By
writing a put option, a Portfolio will be exposed to the amount by which the
price of the underlying is less than the strike price.
 
    By writing an option, a Portfolio incurs an obligation either to buy (in the
case of a put option) or sell (in the case of a call option) the underlying from
the purchaser of the option at the option's exercise price, upon exercise by the
purchaser. Pursuant to guidelines established by the Board of Directors, the
Portfolios may only write options that are "covered." A covered call option
means that until the expiration of the option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will continue to own (i) the underlying; (ii) securities or instruments
convertible or exchangeable without the payment of any consideration into the
underlying; or (iii) a call option on the same underlying with a strike price no
higher than the price at which the underlying was sold pursuant to a short
option position. In the case of a put option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will own another put option on the same underlying with an equal or higher
strike price.
 
    There currently are limited options markets in many countries, particularly
emerging market countries, and the nature of the strategies adopted by the
Adviser and the extent to which those strategies are used will depend on the
development of these options markets. The primary risks associated with the
Portfolios' use of options as described include (i) imperfect correlation
between the change in market value of investments held, purchased or sold by a
Portfolio and the prices of options relating to such investments, and (ii)
possible lack of a liquid secondary market for an option.
 
INTEREST RATE, CURRENCY, COMMODITY AND EQUITY SWAPS, CAPS, COLLARS AND FLOORS
 
    Swaps are privately negotiated over-the-counter derivative products in which
two parties agree to exchange payment streams calculated in relation to a rate,
index, instrument or certain securities and a particular "notional amount." As
with many of the other derivative products available to the Portfolios, the
underlying may include an interest rate (fixed or floating), a currency exchange
rate, a commodity price index, and a security, securities index or a combination
thereof. A great deal of flexibility is possible in the way the products may be
structured, with the effect being that the parties may have exchanged amounts
equal to the return on one rate, index or group of securities for another. For
example, in a simple fixed-to-floating interest rate swap, one party makes
payments equivalent to a fixed interest rate, and the other makes payments
equivalent to a specified interest rate index. A Portfolio may engage in simple
or more complex swap transactions involving a wide variety of underlyings. The
currency swaps that the Portfolios may enter will generally involve an agreement
to pay interest streams in one currency based on a specified index in exchange
for receiving interest streams denominated in another currency. Such swaps may
involve initial and final exchanges that correspond to the agreed upon notional
amount.
 
    Caps, collars and floors are privately-negotiated option-based derivative
products. A Portfolio may use one or more of these products in addition to or in
lieu of a swap involving a similar rate or index. As in the case of a put or
call option, the buyer of a cap or floor pays a premium to the writer. In
exchange for that premium, the buyer receives the right to a payment equal to
the differential if the specified index or rate rises above (in the case of a
cap) or falls below (in the case of a floor) a pre-determined strike level. As
in the case of swaps, obligations under caps and floors are calculated based
upon an agreed notional amount, and like most swaps (other than foreign currency
swaps), the entire notional amount is not exchanged and thus is not at risk. A
collar
 
                                       28
<PAGE>
is a combination product in which the same party, such as the Portfolio, buys a
cap from and sells a floor to the other party. As with put and call options, the
amount at risk is limited for the buyer, but, if the cap or floor is not hedged
or covered, may be unlimited for the seller. Under current market practice,
caps, collars and floors between the same two parties are generally documented
under the same "master agreement." In some cases, options and forward agreements
may also be governed by the same master agreement. In the event of a default,
amounts owed under all transactions entered into under, or covered by, the same
master agreement would be netted and only a single payment would be made.
 
    Swaps, caps, collars and floors are credit-intensive products. A Portfolio
that enters into a swap transaction bears the risk of default, i.e. nonpayment,
by the other party. The guidelines under which each Portfolio enters derivative
transactions, along with some features of the transactions themselves, are
intended to reduce these risks to the extent reasonably practicable, although
they cannot eliminate the risks entirely. Under guidelines established by the
Board of Directors, a Portfolio may enter into swaps only with parties that meet
certain credit rating guidelines. Consistent with current market practices, a
Portfolio will generally enter into swap transactions on a net basis, and all
swap transactions with the same party will be documented under a single master
agreement to provide for net payment upon default. In addition, a Portfolio's
obligations under an agreement will be accrued daily (offset against any amounts
owing to the Portfolio) and any accrued, but unpaid, net amounts owed to the
other party to a master agreement will be covered by the maintenance of a
segregated account consisting of cash or liquid securities.
 
    Interest rate and total rate of return (fixed income or equity) swaps
generally do not involve the delivery of securities, other underlying assets, or
principal. In such case, if the other party to an interest rate or total rate of
return swap defaults, a Portfolio's risk of loss will consist of the payments
that a Portfolio is contractually entitled to receive from the other party. This
may not be true for currency swaps that require the delivery of the entire
notional amount of one designated currency in exchange for the other. If there
is a default by the other party, a Portfolio may have contractual remedies
pursuant to the agreements related to the transaction.
 
STRUCTURED NOTES
 
    Structured notes are derivative securities for which the amount of principal
repayment and/or interest payments is based upon the movement of one or more
factors. These factors include, but are not limited to, currency exchange rates,
interest rates (such as the prime lending rate and LIBOR) and stock indices,
such as the S&P 500. In some cases, the impact of the movements of these factors
may increase or decrease through the use of multipliers or deflators. The
Portfolios may use structured notes to tailor their investments to the specific
risks and returns the Adviser wishes to accept while avoiding or reducing
certain other risks.
 
                             INVESTMENT LIMITATIONS
 
    Each Portfolio is a non-diversified portfolio under the 1940 Act, which
means that the Portfolio is not limited by the 1940 Act in the proportion of its
assets that may be invested in the obligations of a single issuer. Thus, each
Portfolio may invest a greater proportion of its total assets in the securities
of a smaller number of issuers and, as a result, will be subject to greater risk
with respect to its portfolio securities. Nevertheless, each Portfolio intends
to comply with the more limited diversification requirements imposed by the
Internal Revenue Code of 1986, as amended (the "Code"), for qualification as a
regulated investment company.
 
                                       29
<PAGE>
    Each Portfolio operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of the
holders of a majority of the Portfolio's outstanding shares and under certain
non-fundamental investment limitations that may be changed without shareholder
approval. For additional information on fundamental and non-fundamental
investment limitations, see "Investment Limitations" in the Statement of
Additional Information.
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and each Portfolio. The Adviser provides investment
advice and portfolio management services pursuant to an Investment Advisory
Agreement and, subject to the supervision of the Fund's Board of Directors,
makes each of the Portfolio's day-to-day investment decisions, arranges for the
execution of portfolio transactions and generally manages each of the
Portfolio's investments. The Adviser is entitled to receive from each Portfolio
an annual management fee, payable quarterly, equal to the percentage of average
daily net assets set forth in the table below. However, the Adviser has
voluntarily agreed to a reduction in the fees payable to it and to reimburse the
Portfolio, if necessary, if such fees would cause the total annual operating
expenses of each Portfolio to exceed the respective percentages of average daily
net assets set forth in the table below.
 
<TABLE>
<CAPTION>
                                                  MAXIMUM TOTAL ANNUAL
                                                        OPERATING
                                                   EXPENSES AFTER FEE
                                                         WAIVERS
                                  MANAGEMENT    -------------------------
          PORTFOLIO                   FEE        CLASS A         CLASS B
- ------------------------------    -----------   ---------       ---------
<S>                               <C>           <C>             <C>
Emerging Markets Portfolio             1.25%       1.75%           2.00%
Emerging Markets Debt
 Portfolio                             1.00%       1.75%           2.00%
Latin American Portfolio               1.10%       1.70%           1.95%
</TABLE>
 
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to customers in the
United States and abroad. Morgan Stanley Dean Witter & Co. ("MSDW") is the
direct parent of the Adviser and Morgan Stanley. MSDW is a preeminent global
financial services firm that maintains leading market positions in each of its
three primary businesses -- securities, asset management and credit services. At
March 31, 1998, the Adviser, together with its affiliated institutional asset
management companies, managed assets of approximately $166 billion, including
assets under fiduciary advice. See "Management of the Fund" in the Statement of
Additional Information.
 
    PORTFOLIO MANAGERS.  The following individuals have primary portfolio
management responsibility for the Portfolios noted below:
 
    EMERGING MARKETS PORTFOLIO -- MADHAV DHAR AND ROBERT L. MEYER.  Madhav Dhar
joined the Adviser in 1984. He is a Managing Director of the Adviser and of
Morgan Stanley. He is a member of the Adviser's executive committee, head of the
Adviser's emerging markets group and chief investment officer of the Adviser's
global emerging market equity accounts. He holds a B.S. (honors) from St.
Stephen's College, Delhi University India and an M.B.A. from Carnegie-Mellon
University. Mr. Dhar has been primarily responsible for managing the Portfolio's
assets since it commenced operations. Robert L. Meyer joined the Adviser in
1989. He is a Managing Director of the Adviser and of Morgan Stanley and
co-manager of the Adviser's emerging markets group and head of the Adviser's
Latin American team. He was born in Argentina and graduated from Yale
 
                                       30
<PAGE>
University with a B.A. in Economics and Political Science. He received a J.D.
from Harvard Law School. In addition, he is also a Chartered Financial Analyst.
Mr. Meyer has worked with Mr. Dhar in managing the Portfolio's assets since its
inception.
 
    EMERGING MARKETS DEBT PORTFOLIO -- PAUL GHAFFARI.  Paul Ghaffari is a
Managing Director of the Adviser and of Morgan Stanley. He joined the Adviser in
June 1993 as a Vice President and Portfolio Manager for the Morgan Stanley
Emerging Markets Debt Fund (a closed-end investment company). Prior to joining
the Adviser, Mr. Ghaffari was a Vice President in the Fixed Income Division of
the Emerging Markets Sales and Trading Department at Morgan Stanley. From 1983
to 1992, he worked in LDC Sales and Trading Department and the Mortgage-Backed
Securities Department at J.P. Morgan & Co. Inc. and worked in the Treasury
Department at the Morgan Guaranty Trust Co. He holds a B.A. in International
Relations from Pamona College and an M.S. in Foreign Service from Georgetown
University. Mr. Ghaffari has had primary responsibility for managing the
Portfolio's assets since inception.
 
    LATIN AMERICAN PORTFOLIO -- ROBERT L. MEYER AND ANDY SKOV.  Robert L. Meyer
and Andy Skov share primary responsibility for managing the Portfolio's assets.
Information about Mr. Meyer is included under the Emerging Markets Portfolio
above. Andy Skov joined the Adviser in 1994 as a Portfolio Manager. Currently,
he is a Principal of the Adviser and of Morgan Stanley. Prior to joining the
Adviser, he worked in the Latin America group at Bankers Trust in corporate
finance, research and sales; two of those years he spent in Argentina. He
graduated from the University of California at Berkeley with a B.A. (Phi Beta
Kappa) in Political Science and Economics Development.
 
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the officers and the
Board of Directors of the Fund and include day-to-day administration of matters
related to the corporate existence of the Fund, maintenance of its records,
preparation of reports, supervision of the Fund's arrangements with its
custodian and assistance in the preparation of the Fund's registration
statements under federal laws. The Administration Agreement also provides that
the Administrator, through its agents, will provide dividend disbursing and
transfer agent services to the Fund. For its services under the Administration
Agreement, the Fund pays the Adviser a monthly fee which on an annual basis
equals 0.15% of the average daily net assets of each Portfolio.
 
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors administrative services provided by CGFSC. Their
services are also subject to the supervision of the Board of Directors of the
Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of each Portfolio upon the terms and at the current
offering price described in this Prospectus. Morgan Stanley is not obligated to
sell any certain number of shares of any Portfolio.
 
                                       31
<PAGE>
    The Portfolios currently offer only the classes of shares offered by this
Prospectus. The Portfolio may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares for each Portfolio pursuant to Rule 12b-1 under the 1940 Act (each, a
"Plan"). Under each Plan, the Distributor is entitled to receive from the
Portfolios a distribution fee, which is accrued daily and paid quarterly, of
0.25% of the Class B shares' average daily net assets on an annualized basis.
Each Plan is designed to compensate the Distributor for its services in
connection with distribution assistance. The Distributor may retain any portion
of the fee that it does not expend in meeting its obligations to the Fund. The
Distributor may compensate financial intermediaries, plan fiduciaries and
administrators for providing distribution-related services, including account
maintenance services, to shareholders (including, where applicable, underlying
beneficial owners) of Class B shares.
 
    EXPENSES.  Each Portfolio is responsible for payment of certain other fees
and expenses (including organizational costs, legal fees, accountant's fees,
custodial fees, and printing and mailing costs) as specified in its agreements
with the Adviser and Morgan Stanley.
 
    YEAR 2000.  The management and distribution services provided to the Fund by
the Adviser and Morgan Stanley depend on the smooth functioning of their
computer systems. Many computer software systems in use today cannot recognize
the year 2000, but revert to 1900 or some other date, due to the manner in which
dates were encoded and calculated. That failure could have a negative impact on
the handling of securities trades, pricing and account services. The Adviser and
Morgan Stanley have been actively working on necessary changes to their own
computer systems to deal with the year 2000 problem and expect that their
systems will be adapted before that date. There can be no assurance, however,
that they will be successful. In addition, other unaffiliated service providers
may be faced with similar problems. The Adviser and Morgan Stanley are
monitoring their remedial efforts, however, there can be no assurance that they
and the services they provide will not be adversely affected.
 
    In addition, it is possible that the markets for securities in which the
Portfolios invest may be detrimentally affected by computer failures throughout
the financial services industry beginning January 1, 2000. Improperly
functioning trading systems may result in settlement problems and liquidity
issues. In addition, corporate and governmental data processing errors may
result in production problems for individual companies and overall economic
uncertainties. Earnings of individual issuers will be affected by remediation
costs, which may be substantial and may be reported inconsistently in U.S. and
foreign financial statements. Accordingly, the Portfolios' investments may be
adversely affected.
 
                               PURCHASE OF SHARES
 
    Class A shares of each Portfolio and Class B shares of each Portfolio may be
purchased at the net asset value per share next determined after receipt by the
Fund of a purchase order as described under "Methods of Purchase." The net asset
value per share of each Portfolio is calculated on days that the New York Stock
Exchange ("NYSE") and Chase (the "Custodian Bank") are open for business as of
the close of trading of the NYSE, normally 4:00 p.m. Eastern Time (the "Pricing
Time").
 
                                       32
<PAGE>
MINIMUM INVESTMENT
 
    The minimum initial investment is $500,000 for Class A shares and $100,000
for Class B shares of each Portfolio. These minimums may be waived at the
discretion of the Adviser for certain types of investors, including trust
departments, brokers, dealers, agents, financial planners, financial services
firms, investment advisers or various retirement and deferred compensation plans
("Financial Intermediaries"), certain accounts managed by the Adviser and its
affiliates ("Managed Accounts"), and certain employees and customers of Morgan
Stanley and its affiliates. The Fund's determination of an investor's
eligibility to purchase shares of a given class will take precedence over the
investor's selection of a class.
 
METHODS OF PURCHASE
 
    Shares may be purchased directly from the Fund by Federal Funds wire, by
bank wire or by check. Investors may also invest in the Portfolios by purchasing
shares through Financial Intermediaries that have made arrangements with Morgan
Stanley. Some Financial Intermediaries may charge an additional service or
transaction fee. If a purchase is canceled due to nonpayment or because your
check does not clear, you will be responsible for any loss the Fund or its
agents incur. If you are already a shareholder, the Fund may redeem shares from
your account(s) to reimburse the Fund or its agents for any loss. In addition,
you may be prohibited or restricted from making future investments in the Fund.
 
    FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire Federal
Funds to the Fund's bank account. Federal Funds purchase orders will be accepted
only on a day on which the Fund and the Custodian Bank are open for business.
Your bank may charge a service fee for wiring Federal Funds. In order to ensure
proper handling of your purchase by Federal Funds wire, please follow these
steps:
 
    1.  Place your order by telephoning the Fund at 1-800-548-7786. A Fund
       representative will request certain purchase information and provide you
       with a confirmation number.
 
    2.  Instruct your bank to wire the specified amount to the Fund's Wire
       Concentration Bank Account as follows:
 
        The Chase Manhattan Bank
       One Manhattan Plaza
       New York, NY 10081-1000
       ABA# 021000021
       DDA# 910-2-733293
       Attn: Morgan Stanley Institutional Fund, Inc.
       Ref: (Portfolio name, your account number, your account name)
       Please call the Fund at 1-800-548-7786 prior to wiring the funds.
 
    3.  Complete and sign the Account Registration Form and mail it to the
       address shown thereon.
 
    When a purchase order is received prior to the Pricing Time and Federal
Funds are received prior to the close of the Federal Funds Wire Control Center
("FFWCC") (normally 6:00 p.m. Eastern Time), the purchase will be executed at
the net asset value computed on the date of receipt. Purchases for which an
order is received after the Pricing Time or for which Federal Funds are received
after the close of the FFWCC, will be executed at
 
                                       33
<PAGE>
the net asset value next determined. Certain institutional investors and
financial institutions have entered into an arrangement with Morgan Stanley,
pursuant to which they may place orders prior to the Pricing Time, but make
payment in Federal Funds for those shares on the following business day.
 
    BANK WIRE.  A purchase of shares by bank wire must follow the same procedure
as for a Federal Funds wire, described above. However, depending on the time the
bank wire is sent and which bank is handling the wire, money transferred by bank
wire may or may not be converted into Federal Funds prior to the close of the
FFWCC. Prior to conversion to Federal Funds and receipt by the Fund, an
investor's money will not be invested.
 
    CHECK.  An account may be opened by completing and signing an Account
Registration Form and mailing it, together with a check payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio name]" to:
 
    Morgan Stanley Institutional Fund, Inc.
    P.O. Box 2798
    Boston, Massachusetts 02208-2798
 
    The Fund ordinarily is credited with Federal Funds within one business day
of deposit of a check. Thus, a purchase of shares by check ordinarily will be
credited to your account at the net asset value per share of each of the
Portfolios determined on the next business day after receipt. An investor's
money will not be invested prior to crediting of Federal Funds.
 
    INVESTMENT THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to receive purchase and
redemption orders from underlying beneficial owners, such as retirement plan
participants, generally on each business day. Each business evening, the
Financial Intermediary aggregates all orders received from underlying beneficial
owners prior to the Pricing Time on that business day and places a net purchase
and/or redemption order(s) by the morning of the next business day. These orders
normally are executed at the net asset value that was computed for each
Portfolio as of the close of the previous business day.
 
    ADDITIONAL INVESTMENTS.  You may purchase additional shares for your account
at any time by purchasing shares at net asset value by any of the methods
described above. The minimum additional investment generally is $1,000 per
Portfolio. The minimum additional investment may be lower for certain accounts,
described above under "Minimum Investment." For purchases directly from the
Fund, your account name, the Portfolio name and the class selected must be
specified in the letter or wire to assure proper crediting to your account.
 
INVOLUNTARY CONVERSION AND REDEMPTION OF NEW ACCOUNT SHARES
 
    Class A and Class B shares of each Portfolio may be subject to the
involuntary conversion and redemption features described below. The conversion
and redemption features may be waived at the discretion of the Adviser for
shares held in a Managed Account and shares purchased through a Financial
Intermediary. Accounts that were open prior to January 2, 1996 are not subject
to involuntary conversion or redemption. The Fund reserves the right to modify
or terminate the conversion or redemption features of the shares at any time
upon 60 days notice to shareholders.
 
                                       34
<PAGE>
    CONVERSION FROM CLASS A TO CLASS B SHARES.  If the value of an account
containing Class A shares falls below $500,000 (but remains at or above
$100,000) because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $500,000 (but remains at or
above $100,000) for a continuous 60-day period, the Class A shares in such
account will convert to Class B shares and will be subject to the distribution
fee and other features applicable to Class B shares. The Fund will not convert
Class A shares to Class B shares based solely upon changes in the market that
reduce the net asset value of shares. Under current tax law, conversion between
share classes is not a taxable event to the shareholder.
 
    CONVERSION FROM CLASS B TO CLASS A SHARES.  If the value of an account
containing Class B shares increases to $500,000 or more, whether due to
shareholder purchases or market activity, the Class B shares will convert to
Class A shares. Class B shares purchased through a Financial Intermediary that
has entered into an arrangement with the Fund for the purchase of such shares
may not be converted. Under current tax law, such conversion is not a taxable
event to the shareholder. Class A shares converted from Class B shares are
subject to the same minimum account size requirements as are applicable to New
Accounts containing Class A shares described above.
 
    INVOLUNTARY REDEMPTION OF SHARES.  If the value of an account falls below
$100,000 because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $100,000 for a continuous
60-day period, the shares in such account will be subject to redemption by the
Fund. The Fund will not redeem shares based solely upon changes in the market
that reduce the net asset value of shares. If redeemed, redemption proceeds will
be promptly paid to the shareholder.
 
                              REDEMPTION OF SHARES
 
    Class A and Class B shares of each Portfolio may be redeemed at any time and
without charge at the net asset value per share next determined after receipt by
the Fund of a redemption order as described under "Methods of Redemption."
Redemption proceeds may be more or less than the purchase price of your shares
depending on, among other factors, the market value of the investment securities
held by a Portfolio.
 
METHODS OF REDEMPTION
 
    Shares may be redeemed directly from the Fund by mail or by telephone.
However, shares purchased through a Financial Intermediary must be redeemed
through a Financial Intermediary. Certain Financial Intermediaries may charge an
additional service or transaction fee.
 
    BY MAIL.  Each Portfolio will redeem shares upon receipt of a redemption
request in "good order." Redemption requests may be sent by regular mail to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798 or, by overnight courier, to Morgan Stanley Institutional Fund, Inc.,
c/o Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913.
 
    "Good order" means that the request to redeem shares must include the
following:
 
    1. A letter of instruction or a stock assignment specifying the class and
       number of shares or dollar amount to be redeemed, signed by all
       registered owners of the shares in the exact names in which they are
       registered;
 
    2. Any required signature guarantees; and
 
    3. Other supporting legal documents, if required, in the case of estates,
       trusts, guardianships, custodianships, corporations, pension and
       profit-sharing plans and other organizations.
 
                                       35
<PAGE>
    Redemption requests received in "good order" prior to the Pricing Time will
be executed at the net asset value computed on the date of receipt. Redemption
requests received after the Pricing Time will be executed at the next determined
net asset value. Shareholders who are uncertain of requirements for redemption
by mail should consult with a Fund representative.
 
    BY TELEPHONE.  If you have previously elected the Telephone Redemption
Option on the Account Registration Form, you can redeem Portfolio shares by
calling the Fund and requesting that the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. To change the commercial bank or account designated to receive
redemption proceeds, send a written request to the Fund at the address above.
Requests to change the bank or account must be signed by each shareholder and
each signature must be guaranteed. The telephone redemption option may be
difficult to implement at times, particularly during volatile market conditions.
If you experience difficulty in making a telephone redemption, you may redeem
shares by mail as described above.
 
    The Fund and the Transfer Agent will employ reasonable procedures to confirm
that instructions communicated by telephone are genuine. An investor may be
required to provide personal identification information at the time an account
is opened and prior to effecting each telephone transaction. In addition, all
telephone transaction requests will be recorded and investors may be required to
provide additional telecopied written instructions regarding transaction
requests. Neither the Fund nor the Transfer Agent will be responsible for any
loss, liability, cost or expense for following instructions received by
telephone that either of them reasonably believes to be genuine.
 
    REDEMPTION THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to accept redemption
requests from underlying beneficial owners. These redemptions may be processed
in the same way as purchases made through such Financial Intermediaries, as
described above.
 
FURTHER REDEMPTION INFORMATION
 
    The Fund normally makes payment for all shares redeemed within one business
day of receipt of the request, and in no event more than seven days after
receipt of a redemption request in good order. However, payments to investors
redeeming shares which were purchased by check will not be made until payment
for the purchase has been collected, which may take up to eight days after the
date of purchase. The Fund may suspend the right of redemption or postpone the
date upon which redemptions are effected at times when the NYSE is closed, or
under any emergency conditions as determined by the Securities and Exchange
Commission (the "Commission").
 
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of a Portfolio to make payment in
cash, the Fund may pay redemption proceeds in whole or in part by a
distribution-in-kind of readily marketable portfolio securities in accordance
with applicable rules of the Commission. Shareholders may incur brokerage
charges on the sale of portfolio securities received in payment of redemptions.
 
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required to verify the identity of the person who has authorized
certain redemptions. Please contact the Fund or see the Statement of Additional
Information for further information.
 
                                       36
<PAGE>
                         ACCOUNT POLICIES AND SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares of each Portfolio that you own for shares of any
other available portfolio(s) of the Fund, subject to certain limitations. You
cannot exchange for shares of the International Equity, Emerging Markets, Small
Cap Value Equity, Balanced or Gold Portfolios because they are currently closed
to new investors. In addition, certain portfolios may be unavailable to
shareholders who purchased portfolio shares through a Financial Intermediary.
Contact your Financial Intermediary to determine which portfolios are available
for exchange.
 
    Before you make an exchange, you should read the prospectus of the
portfolio(s) in which you seek to invest. The class of shares you receive in the
exchange will be determined in the same manner as any other purchase of shares,
including minimum initial investment and account size requirements, and will not
be based on the class of shares you surrender for the exchange. Exchange
transactions are treated as a redemption followed by a purchase. Therefore, an
exchange will be considered a taxable event for shareholders subject to tax.
Exchange transactions will be processed at the net asset value per share next
determined after receipt of the request. Shares of the portfolios may be
exchanged by mail or telephone. The telephone exchange privilege is automatic
and made available without shareholder election. The exchange privilege may be
modified or terminated by the Fund at any time upon 60-days notice to
shareholders.
 
    BY MAIL.  To exchange shares by mail, send a written exchange request to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798. Your written exchange request should include (i) the name, class of
shares and account number of your current Portfolio; (ii) the name(s) and
class(es) of shares of the portfolio(s) into which you intend to exchange
shares; and (iii) the signatures of all registered account holders.
 
    BY TELEPHONE.  To exchange shares by telephone, call the Fund at the phone
number provided on the cover of this Prospectus. A Fund representative will
request (i) the name, class of shares and account number of your current
Portfolio, and (ii) the name(s) and class(es) of shares of the portfolio(s) into
which you intend to exchange shares. For additional information regarding
responsibility for the authenticity of telephoned instructions, see "Redemption
of Shares" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by sending a written request to Morgan Stanley Institutional Fund, Inc.,
P.O. Box 2798, Boston, Massachusetts 02208-2798. It may not be possible to
transfer the registration of certain shares purchased through a Financial
Intermediary. As with redemptions, the written request must be received in "good
order" before any transfer can be made. Transferring the registration of shares
may affect the eligibility of your account for a given class of shares and may
result in involuntary conversion or redemption of your shares.
 
OTHER ACCOUNT INFORMATION
 
    The Fund does not issue share certificates for the Portfolios. All shares
purchased are confirmed to you and credited to your account on the Fund's books
maintained by the Adviser or its agents. You will have the same rights and
ownership with respect to such shares as if certificates had been issued.
 
                                       37
<PAGE>
EXCESSIVE TRADING
 
    Frequent trades in your account(s) can disrupt management of a Portfolio and
raise its expenses. Consequently, the Fund may, in its discretion and in the
interest of each Portfolio's shareholders and performance, bar a shareholder who
trades excessively from making further share purchases for an indefinite period.
The Fund considers excessive trading to be more than one purchase and sale
involving shares of the same class of a portfolio of the Fund within any 120-day
period. For example, the following series of transactions would amount to
excessive trading: exchanging shares of Portfolio A for shares of Portfolio B,
then exchanging shares of Portfolio B for shares of Portfolio C and then
exchanging shares of Portfolio C for shares of Portfolio A within a 120-day
period. Two types of transactions are exempt from these excessive trading
restrictions: (i) trades exclusively between money market portfolios, and (ii)
trades made in connection with an asset allocation service managed or advised by
the Adviser and/or any of its affiliates.
 
INVESTMENT IN PORTFOLIOS BY OTHER INVESTMENT ACCOUNTS
 
    Morgan Stanley or its affiliates, including Morgan Stanley Asset Management
Inc., manage investment accounts for other clients, including other investment
companies, that invest in Class A or Class B shares of the portfolios. From time
to time, one or more of the Portfolios used for investment by these accounts may
experience relatively large investments or redemptions due to investment
decisions made on behalf of these accounts. These transactions will affect the
portfolios, since portfolios that experience significant redemptions may have to
sell portfolio securities and portfolios that receive additional cash will have
to invest it in additional portfolio securities. It is impossible to predict the
overall impact of these transactions over time, however, there could be adverse
effects on portfolio management. These transactions also could have tax
consequences if sales of portfolio securities result in gains or could increase
transaction costs. The Adviser, representing the interests of the portfolios, is
committed to minimizing the impact of these transactions to the portfolios. The
Adviser, however, will have a conflict in fulfilling this responsibility in that
it also advises these investment accounts. The Adviser will monitor the impact
of these transactions on the Portfolios.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of the Portfolios is
determined by dividing the total market value of the Portfolio's investments and
other assets attributable to such class, less any liabilities attributable to
such class, by the total number of outstanding shares of such class of the
Portfolio. Net asset value is calculated separately for each class of the
Portfolio. Net asset value per share is determined as of the close of the NYSE
(normally 4:00 p.m. Eastern Time) on each day that the NYSE is open for
business. Price information on listed securities is taken from the exchange
where the security is primarily traded. Securities listed on a U.S. securities
exchange for which market quotations are available are valued at the last quoted
sale price on the day the valuation is made. Securities listed on a foreign
exchange are valued at their closing price. Unlisted securities and listed
securities not traded on the valuation date and for which market quotations are
not readily available are valued at a price within a range not exceeding the
current asked price nor less than the current bid price. The current bid and
asked prices are determined based on the average of the bid and asked prices
quoted on such valuation date by reputable brokers.
 
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily. In addition, bonds and other fixed income securities may be
valued on the basis of prices provided by a pricing service when such prices are
believed to reflect the fair market value of such securities. The prices
provided by a pricing service are determined without regard to bid or last sale
prices, but
 
                                       38
<PAGE>
take into account institutional size trading in similar groups of securities and
any developments related to the specific securities. Securities not priced in
this manner are valued at the most recently quoted bid price, or when securities
exchange valuations are used, at the latest quoted sale price on the day of
valuation. If there is no such reported sale, the latest quoted bid price will
be used. Securities purchased with remaining maturities of 60 days or less are
valued at amortized cost, if it approximates market value. In the event that
amortized cost does not approximate market value, market prices as determined
above will be used.
 
    The value of other assets and securities for which quotations are not
readily available (including restricted and unlisted foreign securities) and
those securities for which it is inappropriate to determined prices in
accordance with the above-stated procedures are determined in good faith at fair
value using methods determined by the Board of Directors. For purposes of
calculating net asset value per share, all assets and liabilities initially
expressed in foreign currencies will be translated into U.S. dollars at the mean
of the bid and asked price of such currencies against the U.S. dollar last
quoted by a major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distributions expense accrual differential among the classes. The
net asset value of Class B shares will generally be lower than the net asset
value of the Class A shares as a result of the distribution expense charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise the total return for each class of
the Portfolios. THESE FIGURES ARE BASED ON HISTORICAL EARNINGS AND ARE NOT
INTENDED TO INDICATE FUTURE PERFORMANCE.
 
    "Total return" shows what an investment in a class of the Portfolio would
have earned over a specified period of time (such as one, five or ten years),
assuming that all distributions and dividends by the Portfolio were reinvested
in the same class on the reinvestment dates during the period. Total return does
not take into account any federal or state income taxes that may be payable on
dividends and distributions or upon redemption. The Fund may also include
comparative performance information in advertising or marketing the Portfolios'
shares, including data from Lipper Analytical Services, Inc., other industry
publications, business periodicals, rating services and market indices.
 
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains distributions for a class of shares
will be automatically reinvested in additional shares at net asset value, except
when, upon written notice to the Fund or by checking off the appropriate box in
the Distribution Option Section on the Account Registration Form, a shareholder
elects to receive income dividends and capital gains distributions in cash.
 
    Each Portfolio expects to distribute substantially all of its taxable net
investment income in the form of annual dividends. Net realized capital gains of
each Portfolio, if any, after reduction for any tax loss carryforwards will also
be distributed annually.
 
                                       39
<PAGE>
    Undistributed net investment income is included in each Portfolio's net
assets for the purpose of calculating net asset value per share. Therefore, on
the "ex-dividend" date, the net asset value per share excludes the dividend
(I.E., is reduced by the per share amount of the dividend). Dividends paid
shortly after the purchase of shares by an investor, although in effect a return
of capital, are taxable to shareholders subject to income tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of each Portfolio will differ at times.
Expenses of each Portfolio allocated to a particular class of shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of a Portfolio or its shareholders.
Accordingly, shareholders are urged to consult their tax advisors regarding
specific questions as to federal, state and local income taxes.
 
    Each Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other portfolios. Each Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Code, so that the Portfolio will be relieved
of federal income tax on that part of its net investment income and net capital
gain that is distributed to shareholders.
 
    Each Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, net short-term capital gain) to
shareholders. Dividends from a Portfolio's net investment income are taxable to
shareholders as ordinary income, whether received in cash or in additional
shares. Such dividends paid by a Portfolio generally will not qualify for the
dividends-received deduction for corporate shareholders. Each Portfolio will
report annually to its shareholders the amount of dividend income qualifying for
such treatment.
 
    Distributions of net capital gain are taxable to shareholders as a 20% rate
gain distribution (taxed at a rate of 20%) or a 28% rate gain distribution
(taxed at a rate of 28%), depending upon the designation by the Portfolio (such
designation being dependent upon the holding period of the Portfolio in the
underlying asset generating the net capital gain), regardless of how long
shareholders have held their shares. Each Portfolio will send reports annually
to shareholders of the federal income tax status of all distributions made
during the preceding year.
 
    Each Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gain over short-term and long-term capital
losses, including any available capital loss carryforwards), prior to the end of
each calendar year to avoid liability for federal excise tax.
 
    Dividends and other distributions declared by a Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders on December 31 of that year if the distributions are paid by
the Portfolio at any time during the following January.
 
                                       40
<PAGE>
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any dividends, capital gains distributions and redemption proceeds paid to any
individual or certain other non-corporate shareholder (i) who has failed to
provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Account Registration Form; (ii) who is subject to backup withholding by the
Internal Revenue Service; or (iii) who has not certified to the Fund that such
shareholder is not subject to backup withholding. This backup withholding is not
an additional tax, and any amounts withheld may be credited against the
shareholder's ultimate U.S. tax liability.
 
    The sale, exchange or redemption of shares will result in taxable gain or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the sale, exchange or redemption proceeds exceed or are
less than the shareholder's tax adjusted basis in the sold, exchanged or
redeemed shares. If capital gains distributions have been made with respect to
shares that are sold at a loss after being held for six months or less, then the
loss is treated as a long-term capital loss to the extent of the capital gains
distributions.
 
    Conversions of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisors concerning the
application of state and local income taxes to investments in a Portfolio, which
may differ from the federal income tax consequences described above.
 
    Investment income received by a Portfolio from sources within foreign
countries may be subject to foreign income taxes withheld at the source. To the
extent that a Portfolio is liable for foreign income taxes so withheld, each
Portfolio intends to operate so as to meet the requirements of the Code to pass
through to the shareholders credit for foreign income taxes paid. Although each
Portfolio intends to meet Code requirements to pass through credit for such
taxes, there can be no assurance that each Portfolio will be able to do so.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN THE PORTFOLIO.
 
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolio
for their clients.
 
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other remuneration paid to Morgan Stanley or other affiliates must be
fair and reasonable in comparison to those of other broker-dealers for
comparable transactions involving similar securities being purchased or sold
during a comparable time period.
 
                                       41
<PAGE>
PORTFOLIO TURNOVER
 
    The Portfolios generally do not invest for short-term trading purposes,
however, when circumstances warrant, each Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolios will not consider portfolio turnover rate
a limiting factor in making investment decisions consistent with their
respective objectives and policies. For the fiscal year ended December 31, 1997,
the Emerging Markets Debt and Latin American Portfolios had portfolio turnover
rates of 417% and 286%, respectively. Higher portfolio turnover (e.g., over
100%) necessarily will cause the Portfolios to pay correspondingly increased
brokerage and trading costs. In addition to transaction costs, higher portfolio
turnover may result in the realization of capital gains. As discussed under
"Taxes," to the extent net short-term capital gains are realized, any
distributions resulting from such gains are considered ordinary income for
federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 40 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of each
Portfolio are currently classified into two classes, the Class A shares and the
Class B shares.
 
    The shares of the Portfolios, when issued, will be fully paid,
nonassessable, fully transferable and redeemable at the option of the holder.
The shares have no preference as to conversion, exchange, dividends, retirement
or other features and have no pre-emptive rights. The shares of each Portfolio
have non-cumulative voting rights, which means that the holders of more than 50%
of the shares voting for the election of Directors can elect 100% of the
Directors if they choose to do so. Persons or organizations owning 25% or more
of the outstanding shares of a Portfolio may be presumed to "control" (as that
term is defined in the 1940 Act) that Portfolio. Under Maryland law, the Fund is
not required to hold an annual meeting of its shareholders unless required to do
so under the 1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual and semi-annual reports. The
financial statements appearing in annual reports are audited by independent
accountants. Monthly unaudited portfolio data is also available from the Fund
upon request.
 
    In addition, the Adviser, or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
CUSTODIAN
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs sub-custodians approved by the Board of Directors of the Fund
in accordance with regulations of the Commission for
 
                                       42
<PAGE>
the purpose of providing custodial services for such assets. MSTC may also hold
certain domestic assets for the Fund. For more information on the custodians,
see "General Information -- Custody Arrangements" in the Statement of Additional
Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits its annual financial statements.
 
FUND COUNSEL
 
    Morgan, Lewis & Bockius LLP acts as the Fund's legal counsel.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       43
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
  EMERGING MARKETS, EMERGING MARKETS DEBT AND LATIN AMERICAN PORTFOLIOS
   P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                            <C>
      ACCOUNT INFORMATION                            If you need assistance in filling out this form for the Morgan Stanley
      Fill in where applicable                       Institutional Fund, Inc., please contact your Morgan Stanley
                                                     representative or call us toll free 1-800-548-7786. Please print all
                                                     items except signature, and mail to the Fund at the address above.
 
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
         TENANCY IN COMMON
         IS INDICATED)
</TABLE>
 
1.
         First Name    Initial         Last Name
 
2.
         First Name    Initial         Last Name
 
         First Name    Initial         Last Name
 
<TABLE>
<C>   <S>                                            <C>
      3. CORPORATIONS,
         TRUSTS AND OTHERS
         Please call the Fund for additional
      documents that may be required to set up
      account and to authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                     <C>                 <C>                   <C>               <C>
Type of Registration:   / / INCORPORATED    / / UNINCORPORATED    / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                            ASSOCIATION                               (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
 
<TABLE>
<C>   <S>                                            <C>
  B)  MAILING ADDRESS
      Please fill in completely, including
      telephone number(s).
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
 
/ / Non-Resident Alien
 
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
 
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
 
<TABLE>
<C>   <S>                                            <C>                                  <C>
  C)  TAXPAYER                                       Enter your Taxpayer Identification Number. For most individual
      IDENTIFICATION                                 taxpayers, this is your Social Security Number.
      NUMBER
      1. INDIVIDUAL
      2.   JOINT TENANTS
           (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
           TENANCY IN COMMON
           IS INDICATED).
      For Custodian account
      of a minor (Uniform
      Gifts/Transfers to Minor
      Acts), give the Social
      Security Number of
      the minor.
</TABLE>
<PAGE>
<TABLE>
<C>   <S>                                            <C>                                  <C>
                                                                                          OR
                                                     1.         TAXPAYER IDENTIFICATION                      SOCIAL SECURITY
                                                     NUMBER ("TIN")                                NUMBER ("SSN")
                                                                                              OR
                                                     2.                             TIN
                                                                                                                             SSN
                                                                                              OR
                                                     TIN
                                                                                                                             SSN
 
                                                     IMPORTANT TAX INFORMATION
                                                     You (as a payee) are required by law to provide us (as payer) with your
                                                     correct TIN(s) or SSN(s). Accounts that have a missing or incorrect
                                                     TIN(s) or SSN(s) will be subject to backup withholding at a 31% rate on
                                                     dividends, distributions and other payments. If you have not provided us
                                                     with your correct TIN(s) or SSN(s), you may be subject to a $50 penalty
                                                     imposed by the Internal Revenue Service.
                                                     Backup withholding is not an additional tax; the tax liability of
                                                     persons subject to backup withholding will be reduced by the amount of
                                                     tax withheld. If withholding results in an overpayment of taxes, a
                                                     refund may be obtained.
                                                     You may be notified that you are subject to backup withholding under
                                                     Section 3406(a)(1)(C) of the Internal Revenue Code because you have
                                                     underreported interest or dividends or you were required to, but failed
                                                     to, file a return which would have included a reportable interest or
                                                     dividend payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>                             <C>                   <C>
  D)  PORTFOLIO AND                        For Purchase of the following   / / Class A Shares $  / / Class B Shares $
      CLASS SECTION                        Portfolio(s):                   / / Class A Shares $  / / Class B Shares $
      (Class A shares minimum $500,000     Emerging Markets Portfolio      / / Class A Shares $  / / Class B Shares $
      for each Portfolio and Class B       Emerging Markets Debt
      shares minimum $100,000 for each     Portfolio
      Portfolio.) Please indicate          Latin American Portfolio
      Portfolio, class and amount.
                                                                           Total Initial Investment $
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate portfolio
      and manner of payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                          <C>
/ / Exchange $ From                                                                     - - - - - - - - - - - -- - -
                            Name of Portfolio                                                   Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on                 -- - - - - - - - - - -- - -
                                                                                       Account No.            (Check
                                                                                (Previously assigned by the Fund)     Digit)
                                                                                                                          Date
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  F)  DISTRIBUTION               Income dividends and capital gains distributions (if any) to
      OPTION                     be reinvested in additional shares unless either box below
                                 is checked.
                                 / / Income dividends to be paid in cash, capital gains
                                 distributions (if any) in shares.
                                 / / Income dividends and capital gains distributions (if
                                 any) to be paid in cash.
</TABLE>
 
<TABLE>
<C>   <S>                             <C>                                       <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone         Name of Commercial Bank (Not Savings
      AND EXCHANGE                    requests to wire redemption proceeds to   Bank)
      OPTION                          the commercial bank indicated at right    Bank Account No.
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund
      wish to redeem or exchange      account is registered if such requests                                        Bank
      shares by telephone. A          are believed to be authentic.                                                  ABA
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent                                         No.
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated    Name(s) in which your Bank Account is
      YOUR FUND ACCOUNT.              by telephone are genuine. These           Established
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal      Bank's Street
      NOT BE HONORED UNLESS THE BOX   identification information at the time    Address
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by   City  State  Zip
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  H)  INTERESTED PARTY
      OPTION                                                                                                Name
      In addition to the account
      statement sent to my/our registered
      address, I/we hereby authorize the                                                                   Address
      Fund to mail duplicate statements
      to the name and address provided at  City         State         Zip Code
      right.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  I)  DEALER
      INFORMATION
                                           Representative Name              Representative No.             Branch
                                           No.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here ,
</TABLE>
 
<TABLE>
<S>                                  <C>
The undersigned certify that I/we have full authority and legal capacity
to purchase and redeem shares of the Fund and affirm that I/we have
received a current Prospectus of the Morgan Stanley Institutional Fund,
Inc. and agree to be bound by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF
PERJURY THAT THE INFORMATION ON THIS APPLICATION IS COMPLETE AND CORRECT
AND THAT AS REQUIRED BY FEDERAL LAW (PLEASE CHECK APPLICABLE BOXES
BELOW):
 
/ / U.S. CITIZEN(S)/TAXPAYER(S):
 
      / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM
          IS/ARE THE CORRECT SSN(S) OR TIN(S) AND (2) I/WE ARE NOT
          SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE ARE
          EXEMPT FROM BACKUP WITHHOLDING; (B) I/WE HAVE NOT BEEN
          NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT I/WE ARE
          SUBJECT TO BACKUP WITHHOLDING AS A RESULT OF A FAILURE TO
          REPORT ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED
          ME/US THAT I AM/WE ARE NO LONGER SUBJECT TO BACKUP
          WITHHOLDING.
 
      / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE HAVE
          APPLIED, OR INTEND TO APPLY, TO THE IRS OR THE SOCIAL SECURITY
          ADMINISTRATION FOR A TIN OR A SSN AND I/WE UNDERSTAND THAT IF
          I/ WE DO NOT PROVIDE EITHER NUMBER TO CHASE GLOBAL FUNDS
          SERVICES COMPANY ("CGFSC") WITHIN 60 DAYS OF THE DATE OF THIS
          APPLICATION OR IF I/WE FAIL TO FURNISH MY/OUR CORRECT SSN(S)
          OR TIN(S), I/WE MAY BE SUBJECT TO A PENALTY AND A 31% BACKUP
          WITHHOLDING ON DISTRIBUTIONS AND REDEMPTION PROCEEDS. (PLEASE
          PROVIDE EITHER NUMBER ON IRS FORM W-9). YOU MAY REQUEST SUCH
          FORM BY CALLING CGFSC AT 800-282-4404.
 
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
  UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S.
CITIZENS OR RESIDENTS AND I/WE ARE EXEMPT FOREIGN PERSONS AS DEFINED BY
THE INTERNAL REVENUE SERVICE.
 
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY
PROVISION OF THIS DOCUMENT OTHER THAN THE CERTIFICATIONS REQUIRED TO
AVOID BACKUP WITHHOLDING.
 
                                     (X)
(X)                                  Signature (if joint account, both
Signature            Date            must sign)      Date
</TABLE>
<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<S>                                                 <C>
                                                    PAGE
                                                    ----
Fund Expenses.....................................    2
Financial Highlights..............................    4
Prospectus Summary................................    8
Investment Objectives and Policies................   12
Additional Investment Information.................   18
Investment Limitations............................   29
Management of the Fund............................   30
Purchase of Shares................................   32
Redemption of Shares..............................   35
Account Policies and Services.....................   37
Valuation of Shares...............................   38
Performance Information...........................   39
Dividends and Capital Gains Distributions.........   39
Taxes.............................................   40
Portfolio Transactions............................   41
General Information...............................   42
Account Registration Form
</TABLE>
 
                           EMERGING MARKETS PORTFOLIO
                        EMERGING MARKETS DEBT PORTFOLIO
                            LATIN AMERICAN PORTFOLIO
 
                               PORTFOLIOS OF THE
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
 
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  Incorporated
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
                      P.O. BOX 2798, BOSTON, MA 02208-2798
<PAGE>
- ---------------------------------------
- ---------------------------------------
- ---------------------------------------
- ---------------------------------------
<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
     ----------------------------------------------------------------------
 
                            EQUITY GROWTH PORTFOLIO
                           EMERGING GROWTH PORTFOLIO
                          AGGRESSIVE EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
 
                                ----------------
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a series of diversified and non-diversified investment portfolios
("portfolios"). The Fund is designed to provide clients with attractive
alternatives for meeting their investment needs. The Fund currently consists of
thirty-two portfolios representing a broad range of investment choices. This
prospectus (the "Prospectus") pertains to the Class A and the Class B shares of
the Equity Growth, Emerging Growth and Aggressive Equity Portfolios (each, a
"Portfolio" and collectively, the "Portfolios"). The Class A and Class B shares
currently offered by the Portfolios have different minimum investment
requirements and fund expenses. Shares of the Portfolios are offered with no
sales charge, exchange fee or redemption fee.
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator"), and with Morgan Stanley & Co. Incorporated ("Morgan Stanley")
as Distributor, the Fund makes available to institutional investors and high net
worth individual investors a series of portfolios which benefit from the
investment expertise and commitment to excellence associated with Morgan Stanley
and its affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under "Prospectus Summary" below. The Fund
currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging Markets,
European Equity, European Real Estate, Global Equity, International Equity,
International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) EQUITY AND FIXED INCOME -- Balanced
Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global
Fixed Income, High Yield and Municipal Bond Portfolios; and (v) MONEY MARKET --
Money Market and Municipal Money Market Portfolios. Additional information about
the Fund is contained in a "Statement of Additional Information" dated May 1,
1998, which is incorporated herein by reference. The Statement of Additional
Information and the prospectuses pertaining to the other portfolios of the Fund
are available upon request and without charge by writing or calling the Fund at
the address and telephone number set forth above.
 
  THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
    AND EXCHANGE COMMISSION, NOR HAS THE SECURITIES AND EXCHANGE
      COMMISSION PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS.
         ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
                  THE DATE OF THIS PROSPECTUS IS MAY 1, 1998.
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates the expenses and fees that a shareholder of
the Portfolios indicated below will incur:
 
<TABLE>
<CAPTION>
                                                                      EQUITY      EMERGING    AGGRESSIVE
                                                                      GROWTH       GROWTH       EQUITY
SHAREHOLDER TRANSACTION EXPENSES                                     PORTFOLIO    PORTFOLIO    PORTFOLIO
- ------------------------------------------------------------------  -----------  -----------  -----------
<S>                                                                 <C>          <C>          <C>
Maximum Sales Load Imposed on Purchases
  Class A.........................................................     None         None         None
  Class B.........................................................     None         None         None
Maximum Sales Load Imposed on Reinvested Dividends
  Class A.........................................................     None         None         None
  Class B.........................................................     None         None         None
Deferred Sales Load
  Class A.........................................................     None         None         None
  Class B.........................................................     None         None         None
Redemption Fees
  Class A.........................................................     None         None         None
  Class B.........................................................     None         None         None
Exchange Fees
  Class A.........................................................     None         None         None
  Class B.........................................................     None         None         None
</TABLE>
 
<TABLE>
<CAPTION>
                                                                      EQUITY      EMERGING    AGGRESSIVE
ANNUAL FUND OPERATING EXPENSES                                        GROWTH       GROWTH       EQUITY
  (AS A PERCENTAGE OF AVERAGE NET ASSETS)                            PORTFOLIO    PORTFOLIO    PORTFOLIO
- ------------------------------------------------------------------  -----------  -----------  -----------
<S>                                                                 <C>          <C>          <C>
Management Fee (Net of Fee Waivers)*
  Class A.........................................................       0.58%        0.91%        0.74%
  Class B.........................................................       0.58%        0.91%        0.74%
12b-1 Fees
  Class A.........................................................        None         None         None
  Class B.........................................................       0.25%        0.25%        0.25%
Other Expenses
  Class A.........................................................       0.22%        0.34%        0.26%
  Class B.........................................................       0.22%        0.34%        0.26%
                                                                    -----------  -----------  -----------
Total Operating Expenses (Net of Fee Waivers)*
  Class A.........................................................       0.80%        1.25%        1.00%
  Class B.........................................................       1.05%        1.50%        1.25%
                                                                    -----------  -----------  -----------
                                                                    -----------  -----------  -----------
</TABLE>
 
- ------------------------
*  The Adviser has agreed to waive its management fees and/or reimburse the
   Portfolios, if necessary, if such fees would cause the total annual operating
   expenses of each of the Portfolios to exceed a specified percentage of its
   respective average daily net assets. As a result of these reductions, the
   Management Fees stated above are lower than the contractual fees stated under
   "Management of the Fund." The Adviser reserves the right to terminate any of
   its fee waivers and/or expense reimbursements at any time in its sole
   discretion. For further
 
                                       2
<PAGE>
   information on Fund expenses, see "Management of the Fund." Set forth below,
   for each Portfolio, are the management fees and total operating expenses
   absent such fee waivers and/or expense reimbursements as a percentage of
   average daily net assets of the Class A shares and Class B shares,
   respectively, of each Portfolio.
 
<TABLE>
<CAPTION>
                                                                                           TOTAL OPERATING EXPENSES
                                                                                              ABSENT FEE WAIVERS
                                                              MANAGEMENT FEES ABSENT FEE   ------------------------
PORTFOLIO                                                               WAIVERS              CLASS A      CLASS B
- ------------------------------------------------------------  ---------------------------  -----------  -----------
<S>                                                           <C>                          <C>          <C>
Equity Growth...............................................               0.60%                0.82%        1.07%
Emerging Growth.............................................               1.00%                1.34%        1.58%
Aggressive Equity...........................................               0.80%                1.08%        1.33%
</TABLE>
 
    The purpose of the table above is to assist the investor in understanding
the various expenses that an investor in the Portfolios will bear directly or
indirectly. Expenses and fees for each Portfolio are based on actual figures for
the fiscal year ended December 31, 1997. Due to the continuous nature of Rule
12b-1 fees, long-term Class B shareholders may pay more than the equivalent of
the maximum front-end charges otherwise permitted by the National Association of
Securities Dealers, Inc. ("NASD") Conduct Rules.
 
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (i) a 5% annual rate of return, and (ii) redemption
at the end of each time period. As noted in the table above, the Portfolios
charge no redemption fees of any kind. The example is based on total operating
expenses of the Portfolios after fee waivers.
 
<TABLE>
<CAPTION>
                                                                       1 YEAR       3 YEARS      5 YEARS     10 YEARS
                                                                     -----------  -----------  -----------  -----------
<S>                                                                  <C>          <C>          <C>          <C>
Equity Growth Portfolio
  Class A..........................................................   $       8    $      26    $      44    $      99
  Class B..........................................................          11           33           58          128
Emerging Growth Portfolio
  Class A..........................................................          13           40           69          151
  Class B..........................................................          15           47           82          179
Aggressive Equity Portfolio
  Class A..........................................................          10           32           55          122
  Class B..........................................................          13           40           69          151
</TABLE>
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. ACTUAL EXPENSES MAY BE GREATER OR LESS THAN THOSE
SHOWN.
 
                                       3
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following table provides financial highlights for the Class A and Class
B shares of the Equity Growth, Emerging Growth and Aggressive Equity Portfolios
for each of the periods presented. The audited financial highlights for each of
the Portfolio's shares for each of the periods in the five years ended December
31, 1997 are part of the Fund's financial statements which appear in the Fund's
December 31, 1997 Annual Report to Shareholders and which are incorporated by
reference into the Fund's Statement of Additional Information. Each Portfolio's
financial highlights for each of the periods presented have been audited by
Price Waterhouse LLP, whose unqualified report thereon is also incorporated by
reference into the Statement of Additional Information. Additional performance
information is included in the Annual Report. The Annual Report and the
financial statements therein, along with the Statement of Additional
Information, are available at no cost from the Fund at the address and telephone
number noted on the cover page of this Prospectus. After October 31, 1992, the
Fund changed its fiscal year end to December 31. The following information
should be read in conjunction with the financial statements and notes thereto.
 
                                       4
<PAGE>
                            EQUITY GROWTH PORTFOLIO
<TABLE>
<CAPTION>
                                                                                   CLASS A
                                            -------------------------------------------------------------------------------------
                                                                 YEAR ENDED                          TWO MONTHS
                                                                DECEMBER 31,                              ENDED      YEAR ENDED
                                            -----------------------------------------------------  DECEMBER 31,     OCTOBER 31,
                                                 1997       1996       1995       1994       1993          1992            1992
                                            ---------  ---------  ---------  ---------  ---------  --------------  --------------
<S>                                         <C>        <C>        <C>        <C>        <C>        <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD......  $   14.94  $   14.14  $   12.02  $   12.14  $   11.88    $    11.44      $    10.66
                                            ---------  ---------  ---------  ---------  ---------       -------         -------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)...............       0.06       0.17       0.22       0.17       0.22          0.03            0.16
  Net Realized and Unrealized Gain on
   Investments............................       4.48       4.07       4.93       0.21       0.28          0.41            0.82
                                            ---------  ---------  ---------  ---------  ---------       -------         -------
    Total from Investment Operations......       4.54       4.24       5.15       0.38       0.50          0.44            0.98
                                            ---------  ---------  ---------  ---------  ---------       -------         -------
DISTRIBUTIONS
  Net Investment Income...................      (0.06)     (0.17)     (0.28)     (0.13)     (0.23)           --           (0.20)
  In Excess of Net Investment Income......      (0.00)+        --        --         --      (0.01)           --              --
  Net Realized Gain.......................      (2.49)     (3.27)     (2.75)     (0.37)        --            --              --
                                            ---------  ---------  ---------  ---------  ---------       -------         -------
    Total Distributions...................      (2.55)     (3.44)     (3.03)     (0.50)     (0.24)           --           (0.20)
                                            ---------  ---------  ---------  ---------  ---------       -------         -------
NET ASSET VALUE, END OF PERIOD............  $   16.93  $   14.94  $   14.14  $   12.02  $   12.14    $    11.88      $    11.44
                                            ---------  ---------  ---------  ---------  ---------       -------         -------
                                            ---------  ---------  ---------  ---------  ---------       -------         -------
TOTAL RETURN..............................      31.32%     30.97%     45.02%      3.26%      4.33%         3.85%           9.26%
                                            ---------  ---------  ---------  ---------  ---------       -------         -------
                                            ---------  ---------  ---------  ---------  ---------       -------         -------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)...  $ 591,789  $ 352,703  $ 158,112  $  97,259  $  73,789    $   45,985      $   36,558
  Ratio of Expenses to Average Net Assets
   (1)....................................       0.80%      0.80%      0.80%      0.80%      0.80%         0.80%**         0.80%
  Ratio of Net Investment Income to
   Average Net Assets (1).................       0.35%      1.12%      1.57%      1.44%      1.59%         1.93%**         1.73%
  Portfolio Turnover Rate.................        177%       186%       186%       146%       172%            1%             38%
  Average Commission Rate Per Share#......    $0.0562    $0.0535        N/A        N/A        N/A           N/A             N/A
- ----------------------------------
(1) Effect of voluntary expense limitation
    during the period:
     Per share benefit to net investment
      income..............................      $0.00+     $0.01      $0.01      $0.01      $0.02         $0.01           $0.02
   Ratios before expense limitation:
     Expenses to Average Net Assets.......       0.82%      0.88%      0.88%      0.89%      0.93%         1.11%**         1.01%
     Net Investment Income to Average Net
      Assets..............................       0.33%      1.04%      1.49%      1.35%      1.46%         1.62%**         1.52%
- ---------------------------------------------------------------------------------------------------------------------------------
 
<CAPTION>
                                                                                 CLASS B
                                                            ------------------------------
                                             PERIOD FROM                     PERIOD FROM
                                                APRIL 2,                      JANUARY 2,
                                                1991* TO      YEAR ENDED      1996*** TO
                                             OCTOBER 31,    DECEMBER 31,    DECEMBER 31,
                                                    1991            1997            1996
                                            --------------  --------------  --------------
<S>                                         <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD......    $    10.00      $    14.92      $    14.22
                                                 -------         -------         -------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)...............          0.05            0.04            0.13
  Net Realized and Unrealized Gain on
   Investments............................          0.61            4.46            3.99
                                                 -------         -------         -------
    Total from Investment Operations......          0.66            4.50            4.12
                                                 -------         -------         -------
DISTRIBUTIONS
  Net Investment Income...................            --           (0.02)          (0.15)
  In Excess of Net Investment Income......            --              --              --
  Net Realized Gain.......................            --           (2.49)          (3.27)
                                                 -------         -------         -------
    Total Distributions...................            --           (2.51)          (3.42)
                                                 -------         -------         -------
NET ASSET VALUE, END OF PERIOD............    $    10.66      $    16.91      $    14.92
                                                 -------         -------         -------
                                                 -------         -------         -------
TOTAL RETURN..............................          6.60%          31.05%          29.92%
                                                 -------         -------         -------
                                                 -------         -------         -------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)...    $   18,139      $   27,879          $5,498
  Ratio of Expenses to Average Net Assets
   (1)....................................          0.80%**         1.05%           1.05%**
  Ratio of Net Investment Income to
   Average Net Assets (1).................          2.34%**         0.10%           0.91%**
  Portfolio Turnover Rate.................             3%            177%            186%
  Average Commission Rate Per Share#......           N/A         $0.0562         $0.0535
- ----------------------------------
(1) Effect of voluntary expense limitation
    during the period:
     Per share benefit to net investment
      income..............................         $0.03           $0.01           $0.01
   Ratios before expense limitation:
     Expenses to Average Net Assets.......          1.37%**         1.07%           1.12%**
     Net Investment Income to Average Net
      Assets..............................          1.77%**         0.08%           0.84%**
- -----------------------------------------------------------------------------------------------------------
</TABLE>
 
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period.
 
  + Amount is less than $0.01 per share.
 
                                       5
<PAGE>
                           EMERGING GROWTH PORTFOLIO
<TABLE>
<CAPTION>
                                                                             CLASS A
                                  ---------------------------------------------------------------------------------------------
                                                                   YEAR ENDED                                      TWO MONTHS
                                                                  DECEMBER 31,                                        ENDED
                                  -----------------------------------------------------------------------------   DECEMBER 31,
                                      1997            1996            1995            1994            1993            1992
                                  -------------   -------------   -------------   -------------   -------------   -------------
<S>                               <C>             <C>             <C>             <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF
 PERIOD.........................  $       13.50   $       21.49   $       16.12   $       16.22   $       16.22   $     14.97
                                  -------------   -------------   -------------   -------------   -------------   -------------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Loss (1).......          (0.07)          (0.19)          (0.18)          (0.09)          (0.11)        (0.01)
  Net Realized and Unrealized
   Gain (Loss) on Investments...           1.09            0.89            5.55           (0.01)           0.11          1.26
                                  -------------   -------------   -------------   -------------   -------------   -------------
    Total from Investment
     Operations.................           1.02            0.70            5.37           (0.10)           0.00          1.25
                                  -------------   -------------   -------------   -------------   -------------   -------------
DISTRIBUTIONS
  Net Realized Gain.............          (6.80)          (8.69)             --              --              --            --
                                  -------------   -------------   -------------   -------------   -------------   -------------
    Total Distributions.........          (6.80)          (8.69)             --              --              --            --
                                  -------------   -------------   -------------   -------------   -------------   -------------
NET ASSET VALUE, END OF
 PERIOD.........................  $        7.72   $       13.50   $       21.49   $       16.12   $       16.22   $     16.22
                                  -------------   -------------   -------------   -------------   -------------   -------------
                                  -------------   -------------   -------------   -------------   -------------   -------------
TOTAL RETURN....................          11.36%           3.72%          33.31%          (0.62)%          0.00%         8.35%
                                  -------------   -------------   -------------   -------------   -------------   -------------
                                  -------------   -------------   -------------   -------------   -------------   -------------
RATIO AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)..................  $      57,777   $      62,793   $     119,378   $     117,669   $     103,621   $    94,161
  Ratio of Expenses to Average
   Net Assets (1)...............           1.25%           1.25%           1.25%           1.25%           1.25%         1.25%**
  Ratio of Net Investment Loss
   to Average Net Assets (1)....          (0.87)%         (0.88)%         (0.76)%         (0.61)%         (0.77)%       (0.68)%**
  Portfolio Turnover Rate.......            228%             33%             25%             24%             25%            1%
  Average Commission Rate Per
   Share# ......................        $0.0513         $0.0507             N/A             N/A             N/A           N/A
- ----------------------------------
 
(1) Effect of voluntary expense
    limitation during the
    period:
     Per share benefit to net
      investment loss...........          $0.01           $0.01          $0.003          $0.002           $0.01         $0.00
   Ratios before expense
    limitation:
     Expenses to Average Net
      Assets....................           1.34%           1.30%           1.26%           1.26%           1.31%         1.36%**
     Net Investment Loss to
      Average Net Assets........          (0.95)%         (0.92)%         (0.77)%         (0.62)%         (0.83)%       (0.79)%**
- -------------------------------------------------------------------------------------------------------------------------------
 
<CAPTION>
                                                                                             CLASS B
                                                                                  -----------------------------
                                                                                                   PERIOD FROM
                                           YEAR ENDED              NOVEMBER 1,                     JANUARY 2,
                                           OCTOBER 31,              1989* TO       YEAR ENDED      1996*** TO
                                  -----------------------------    OCTOBER 31,    DECEMBER 31,    DECEMBER 31,
                                      1992           1991++           1990            1997            1996
                                  -------------   -------------   -------------   -------------   -------------
<S>                               <C>             <C>             <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF
 PERIOD.........................  $     16.18     $      9.03     $     10.00     $     13.45     $     21.47
                                  -------------   -------------   -------------   -------------   -------------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Loss (1).......        (0.09)             --           (0.08)          (0.06)          (0.15)
  Net Realized and Unrealized
   Gain (Loss) on Investments...        (1.12)           7.19           (1.00)           1.04            0.82
                                  -------------   -------------   -------------   -------------   -------------
    Total from Investment
     Operations.................        (1.21)           7.19           (0.92)           0.98            0.67
                                  -------------   -------------   -------------   -------------   -------------
DISTRIBUTIONS
  Net Realized Gain.............           --           (0.04)          (0.05)          (6.80)          (8.69)
                                  -------------   -------------   -------------   -------------   -------------
    Total Distributions.........           --              --              --           (6.80)          (8.69)
                                  -------------   -------------   -------------   -------------   -------------
NET ASSET VALUE, END OF
 PERIOD.........................  $     14.97     $     16.18     $      9.03     $      7.63     $     13.45
                                  -------------   -------------   -------------   -------------   -------------
                                  -------------   -------------   -------------   -------------   -------------
TOTAL RETURN....................        (7.48)%         79.84%          (9.27)%         11.13%           3.58%
                                  -------------   -------------   -------------   -------------   -------------
                                  -------------   -------------   -------------   -------------   -------------
RATIO AND SUPPLEMENTAL DATA:
  Net Assets, End of Period
   (Thousands)..................  $    80,156     $    54,364     $    11,261     $     1,313          $3,997
  Ratio of Expenses to Average
   Net Assets (1)...............         1.25%           1.25%           1.26%           1.50%           1.50%**
  Ratio of Net Investment Loss
   to Average Net Assets (1)....        (0.66)%          0.00%           0.64%          (1.12)%         (1.09)%**
  Portfolio Turnover Rate.......           17%              2%             19%            228%             33%
  Average Commission Rate Per
   Share# ......................          N/A             N/A             N/A         $0.0513         $0.0507
- --------------------------------
(1) Effect of voluntary expense
    limitation during the
    period:
     Per share benefit to net
      investment loss...........        $0.01           $0.02           $0.01           $0.00+          $0.01
   Ratios before expense
    limitation:
     Expenses to Average Net
      Assets....................         1.29%           1.39%           1.64%**         1.58%           1.54%**
     Net Investment Loss to
      Average Net Assets........        (0.71)%         (0.14)%          0.24%**        (1.21)%         (1.14)%**
- -------------------------------------------------------------------------------------------------------------------------------
 
</TABLE>
 
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period.
 
  + Amount is less than $0.01 per share.
 
 ++ Per share amounts for the year ended October 31, 1991 are based on average
    outstanding shares.
 
                                       6
<PAGE>
                          AGGRESSIVE EQUITY PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                   CLASS A                              CLASS B
                                                   ---------------------------------------  --------------------------------
                                                                                                               PERIOD FROM
                                                   YEAR ENDED DECEMBER      PERIOD FROM                        JANUARY 2,
                                                           31,            MARCH 8, 1995*      YEAR ENDED       1996*** TO
                                                   --------------------   TO DECEMBER 31,    DECEMBER 31,     DECEMBER 31,
                                                     1997       1996           1995              1997             1996
                                                   ---------  ---------  -----------------  ---------------  ---------------
<S>                                                <C>        <C>        <C>                <C>              <C>
NET ASSET VALUE, BEGINNING OF PERIOD.............  $   14.43  $   12.17      $   10.00         $   14.42        $   12.25
                                                   ---------  ---------        -------           -------          -------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)......................       0.01       0.18           0.15             (0.01)            0.13
  Net Realized and Unrealized Gain on
   Investments...................................       4.58       4.73           3.95              4.55             4.67
                                                   ---------  ---------        -------           -------          -------
    Total from Investment Operations.............       4.59       4.91           4.10              4.54             4.80
                                                   ---------  ---------        -------           -------          -------
DISTRIBUTIONS
  Net Investment Income..........................      (0.01)     (0.17)         (0.15)            (0.01)           (0.15)
  In Excess of Net Investment Income.............      (0.00)+        --            --             (0.00)+             --
  Net Realized Gain..............................      (3.23)     (2.48)         (1.78)            (3.23)           (2.48)
                                                   ---------  ---------        -------           -------          -------
    Total Distributions..........................      (3.24)     (2.65)         (1.93)            (3.24)           (2.63)
                                                   ---------  ---------        -------           -------          -------
NET ASSET VALUE, END OF PERIOD...................  $   15.78  $   14.43      $   12.17         $   15.72        $   14.42
                                                   ---------  ---------        -------           -------          -------
                                                   ---------  ---------        -------           -------          -------
TOTAL RETURN.....................................      33.31%     40.90%         41.25%            32.90%           39.72%
                                                   ---------  ---------        -------           -------          -------
                                                   ---------  ---------        -------           -------          -------
RATIO AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)..........  $ 155,087  $  68,480      $  28,548         $  18,277           $8,805
  Ratio of Expenses to Average Net Assets (1)....       1.02%      1.00%          1.00%**           1.27%            1.25%**
  Ratio of Expenses to Average Net Assets
   Excluding Dividend Expense on Securities Sold
   Short and Interest Expense....................       1.00%      1.00%          1.00%**           1.25%            1.25%**
  Ratio of Net Investment Income to Average Net
   Assets (1)....................................       0.08%      1.26%          1.64%**          (0.18)%           0.95%**
  Portfolio Turnover Rate........................        302%       380%          309%               302%             380%
  Average Commission Rate Per Share#.............    $0.0575    $0.0484           N/A            $0.0575          $0.0484
</TABLE>
 
- --------------------
<TABLE>
<C>  <S>                                                           <C>         <C>         <C>             <C>
(1)  Effect of voluntary expense limitation during the period:
       Per share benefit to net investment income................       $0.01       $0.03         $0.06          $0.00+
     Ratios before expense limitation:
       Expenses to Average Net Assets............................        1.08%       1.24%         1.59%**         1.33%
       Net Investment Income to Average Net Assets...............        0.02%       1.02%         1.05%**        (0.24 )%
- -------------------------------------------------------------------------------------------------------------------------
 
<CAPTION>
(1)
<C>  <C>
            $0.03
 
             1.47%**
             0.73%**
- -------------------------------------------------------------------------------------------------------------------------
 
</TABLE>
 
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period.
 
  + Amount is less than $0.01 per share.
 
                                       7
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and high net worth individual investors a broad range of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates providing customized services as Adviser, Administrator and
Distributor. Each portfolio offers Class A shares and Class B shares, except the
International Small Cap and Municipal Money Market Portfolios which offer only
Class A shares. Each portfolio has its own investment objective and policies
designed to meet its specific goals. The investment objective of each Portfolio
described in this Prospectus is as follows:
 
    - The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
      investing in growth-oriented equity securities of medium and large
      capitalization companies.
 
    - The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation by
      investing primarily in growth-oriented equity securities of small- to
      medium-sized corporations.
 
    - The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by investing
      primarily in corporate equity and equity-linked securities.
 
    The other portfolios of the Fund are described in other Prospectuses which
may be obtained from the Fund at the address and phone number noted on the cover
page of this Prospectus. The investment objectives of these other portfolios are
listed below:
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    - The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
      appreciation by investing in accordance with country weightings determined
      by the Adviser in equity securities of non-U.S. issuers which, in the
      aggregate, replicate broad country indices.
 
    - The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of Asian issuers.
 
    - The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
      appreciation by investing primarily in equity securities of companies in
      the Asian real estate industry.
 
    - The CHINA GROWTH PORTFOLIO seeks to provide long-term capital appreciation
      by investing primarily in equity securities of issuers in The People's
      Republic of China, Hong Kong and Taiwan.
 
    - The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of emerging country issuers.
 
    - The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of European issuers.
 
    - The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income and
      long-term capital appreciation by investing primarily in equity securities
      of companies in the European real estate industry.
 
    - The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of issuers throughout the world,
      including U.S. issuers.
 
    - The GOLD PORTFOLIO seeks long-term capital appreciation by investing
      primarily in equity securities of foreign and domestic issuers engaged in
      gold-related activities.
 
                                       8
<PAGE>
    - The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of non-U.S. issuers.
 
    - The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of non-U.S. issuers domiciled in
      EAFE countries.
 
    - The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
      by investing primarily in equity securities of non-U.S. issuers with
      equity market capitalizations of less than $1 billion.
 
    - The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of Japanese issuers.
 
    - The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of Latin American issuers and,
      from time to time, debt securities issued or guaranteed by Latin American
      governments or governmental entities.
 
    U.S. EQUITY:
 
    - The MICROCAP PORTFOLIO seeks long-term capital appreciation by investing
      primarily in growth-oriented equity securities of small corporations.
 
    - The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total return by
      investing in equity securities of small- to medium-sized companies which
      the Adviser believes to be undervalued.
 
    - The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by investing
      primarily in equity securities of companies that, in the opinion of the
      Adviser, are expected to benefit from their involvement in technology and
      technology-related industries.
 
    - The U.S. EQUITY PLUS PORTFOLIO seeks long-term capital appreciation by
      investing primarily in equity securities of issuers included in the
      Standard & Poor's 500 Index ("S&P 500").
 
    - The U. S. REAL ESTATE PORTFOLIO seeks to provide above-average current
      income and long-term capital appreciation by investing primarily in equity
      securities of companies in the U.S. real estate industry, including
      substantial investment in real estate investment trusts.
 
    - The VALUE EQUITY PORTFOLIO seeks high total return by investing in equity
      securities which the Adviser believes to be undervalued relative to the
      stock market in general at the time of purchase.
 
    EQUITY AND FIXED INCOME:
 
    - The BALANCED PORTFOLIO seeks high total return while preserving capital by
      investing in a combination of equity securities which the Adviser believes
      to be undervalued and fixed income securities.
 
    FIXED INCOME:
 
    - The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by investing
      primarily in debt securities of government, government-related and
      corporate issuers located in emerging countries.
 
    - The FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
      with the preservation of capital by investing in a diversified portfolio
      of fixed income securities.
 
    - The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
      of return while preserving capital by investing in fixed income securities
      of issuers throughout the world, including U.S. issuers.
 
                                       9
<PAGE>
    - The HIGH YIELD PORTFOLIO seeks to maximize total return by investing in a
      diversified portfolio of high yield fixed income securities that offer a
      yield above that generally available on debt securities in the four
      highest rating categories of the recognized rating services.
 
    - The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a level
      of current income as is consistent with the preservation of capital by
      investing primarily in a variety of investment grade mortgage-backed
      securities.
 
    - The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of current
      income consistent with preservation of principal by investing in municipal
      obligations, the interest on which is exempt from federal income tax.
 
    MONEY MARKET:
 
    - The MONEY MARKET PORTFOLIO seeks to maximize current income and preserve
      capital while maintaining high levels of liquidity through investing in
      high quality money market instruments with remaining maturities of one
      year or less.
 
    - The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current tax-exempt
      income and preserve capital while maintaining high levels of liquidity
      through investing in high quality money market instruments with remaining
      maturities of one year or less which are exempt from federal income tax.
     THE CHINA GROWTH, GOLD, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS
      ARE CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley Dean Witter & Co., acts as investment adviser to the Fund and each of
its portfolios. As of March 31, 1998, Morgan Stanley Asset Management Inc. and
its affiliated institutional asset management companies managed assets of
approximately $166 billion, including assets under fiduciary advice. See
"Management of the Fund -- Investment Adviser" and "Management of the Fund --
Administrator."
 
HOW TO INVEST
 
    Class A shares of each Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of each
Portfolio are offered at net asset value with no sales commission, but with a
12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25% of the
Class B shares' average daily net assets on an annualized basis. The minimum
initial investment, generally, is $500,000 for Class A shares of each Portfolio
and $100,000 for Class B shares of each Portfolio. The minimum initial
investment amount is reduced for certain categories of investors. For additional
information on how to purchase shares and minimum initial investments, see
"Purchase of Shares."
 
HOW TO REDEEM
 
    Class A shares or Class B shares of each Portfolio may be redeemed at any
time, without cost, at the net asset value per share of the applicable class
next determined after receipt of the redemption request. The redemption price
may be more or less than the purchase price. Certain redemptions that cause the
value of an account to remain for a continuous 60-day period below the minimum
investment amount for Class A shares or
 
                                       10
<PAGE>
for Class B shares may result in involuntary redemption or automatic conversion.
For additional information on how to redeem shares and involuntary redemption or
conversion, see "Purchase of Shares" and "Redemption of Shares."
 
RISK FACTORS
 
    Investing in each of the Portfolios entails certain risks and considerations
of which an investor should be aware. The Portfolios' share prices and
investment returns fluctuate and, when redeemed, an investment in the Portfolios
may be worth more or less than its original cost. The investment policies of the
Portfolios may entail the following risk factors:
 
    - EQUITY SECURITIES. Each Portfolio invests in equity securities. Prices of
     equity securities fluctuate in response to many factors, including the
     financial health of the issuer and changes in economic and market
     conditions.
 
    - FOREIGN INVESTMENT. Each Portfolio may invest in the securities of foreign
     issuers. The risks of foreign investment include fluctuations in foreign
     currency values, political events affecting the country of issuance and
     potentially greater market volatility and lower liquidity.
 
    - DERIVATIVES. Each Portfolio may invest in instruments that derive their
     values from those of specified securities, indices, currencies or other
     points of reference. These derivatives, including those used to manage
     risk, are themselves subject to the risks of the different markets in which
     they are traded and, therefore, may or may not serve their intended
     purposes.
 
For additional information about risk factors, see also "Investment Objectives
and Policies" and "Additional Investment Information."
 
                                       11
<PAGE>
                       INVESTMENT OBJECTIVES AND POLICIES
 
    The investment objective of each Portfolio is described below, together with
the policies each Portfolio will employ in its efforts to achieve its objective.
Each Portfolio's investment objective is a fundamental policy which may not be
changed without the approval of a majority of the Portfolio's outstanding voting
securities. There is no assurance that the Portfolios will attain their
objectives. In addition to the investments and strategies described below, the
Portfolios may invest in certain securities and obligations as set forth in
"Additional Investment Information" and as described under "Investment
Objectives and Policies" in the Statement of Additional Information. The
investment policies described below are not fundamental policies unless
otherwise noted and may be changed without shareholder approval.
 
THE EQUITY GROWTH PORTFOLIO
 
    The Portfolio's investment objective is to provide long-term capital
appreciation by investing in growth-oriented equity securities of medium and
large capitalization U.S. corporations and, to a limited extent, foreign
corporations. With respect to the Portfolio, equity securities include common
and preferred stocks, convertible securities and rights and warrants to purchase
common stocks. Under normal circumstances, the Portfolio will invest at least
65% of the value of its total assets in equity securities.
 
    The Adviser employs a flexible and eclectic investment process in pursuit of
the Portfolio's investment objective and may invest in any equity security that,
in the Adviser's judgment, provides above-average potential for capital
appreciation. In selecting stocks for the Portfolio, the Adviser concentrates on
a universe of rapidly growing, high quality companies and lower, but
accelerating, earnings growth situations. The Adviser's universe of potential
investments generally comprises companies with market capitalizations of $500
million or more. The Portfolio is not restricted to investments in specific
market sectors. In selecting investments for the Portfolio, the Adviser
emphasizes individual security selection. The Portfolio's investments will
generally be diversified by number of issues, but concentrated sector positions
may result from the investment process. Although the Portfolio has a long-term
investment perspective, the Adviser may take advantage of short-term
opportunities that are consistent with the Portfolio's objective by selling
recently purchased securities which have increased in value.
 
    The Adviser uses its research capabilities, analytical resources and
judgment to assess economic, industry and market trends, as well as individual
company developments, to select promising growth investments for the Portfolio.
In addition, the Adviser rigorously assesses company developments, including
changes in strategic direction, management focus and current and likely future
earnings results. Valuation is important to the Adviser, but is viewed in the
context of prospects for sustainable earnings growth and the potential for
positive earnings surprises in relation to consensus expectations.
 
    The Portfolio may invest up to 25% of its total assets at the time of
purchase in securities of foreign companies, either directly or in the form of
Depositary Receipts. The Portfolio also may invest in convertible securities of
domestic and, subject to the above restrictions, foreign issuers on occasions
when the Adviser believes it is more advantageous to purchase such securities
than to purchase common stock.
 
                                       12
<PAGE>
THE EMERGING GROWTH PORTFOLIO
 
    The Portfolio's investment objective is to provide long-term capital
appreciation by investing primarily in growth-oriented equity securities of
small- to medium-sized domestic corporations and, to a limited extent, foreign
corporations. With respect to the Portfolio, equity securities include common
and preferred stocks, convertible securities, and rights and warrants to
purchase common stocks, and any similar equity interest, such as trust or
partnership interests. Such equity securities may not pay dividends or
distributions and may or may not carry voting rights. Although the Portfolio has
a long-term investment perspective, the Adviser may take advantage of short-term
opportunities that are consistent with its objective.
 
    The Adviser employs a flexible investment program in pursuit of the
Portfolio's investment objective and may invest in any common stock which, in
the Adviser's judgment, provides above-average potential for capital
appreciation. The Portfolio is not restricted to investments in specific market
sectors. The Portfolio generally will invest in small- to medium-sized companies
that are early in their life cycle, but which, in the Adviser's judgment, have
the potential to become major enterprises. For example, the Adviser uses its
judgment and research capabilities to assess economic, industry, market and
company developments to select investments in promising emerging growth
companies that are expected to benefit from new technology or new products or
services. In addition, the Adviser looks for special developments, such as
research discoveries, changes in customer demand, rejuvenated management or
basic changes in the economic environment.
 
    The Portfolio may invest up to 25% of its total assets at the time of
purchase in securities of foreign companies, either directly or in the form of
Depositary Receipts. The Portfolio may also invest in convertible securities of
domestic and, subject to the above restrictions, foreign issuers on occasions
when the Adviser believes it is more advantageous to purchase such securities
than to purchase common stock. The Portfolio will not invest in debt securities
that are not rated at least investment grade by either Standard & Poor's Ratings
Group ("S&P") or Moody's Investors Service, Inc. ("Moody's").
 
THE AGGRESSIVE EQUITY PORTFOLIO
 
    The Portfolio's investment objective is to provide capital appreciation by
investing primarily in a non-diversified portfolio of corporate equity and
equity-linked securities. With respect to the Portfolio, equity and
equity-linked securities include common and preferred stocks, convertible
securities, rights and warrants to purchase common stocks, options, futures, and
specialty securities, such as ELKS, LYONs, PERCS of U.S., and to a limited
extent, foreign issuers. Under normal circumstances, the Portfolio will invest
at least 65% of the value of its total assets in equity and equity-linked
securities. The Portfolio has a long-term investment perspective; however, the
Adviser may take advantage of short-term opportunities that are consistent with
the Portfolio's objective by selling recently purchased securities which have
increased in value.
 
    The Adviser employs a flexible and eclectic investment process in pursuit of
the Portfolio's investment objective and may invest in any equity or
equity-linked security that, in the Adviser's judgment, provides above-average
potential for capital appreciation. In selecting securities for the Portfolio,
the Adviser concentrates on a universe of rapidly growing, high quality
companies and lower, but accelerating, earnings growth situations. The Adviser's
universe of potential investments generally comprises companies with market
capitalizations of $500 million or more, but smaller market capitalization
securities may be purchased from time to time. The Portfolio is not restricted
to investments in specific market sectors. The Adviser uses its research
capabilities, analytical resources and judgment to assess economic, industry and
market trends, as well as individual company developments, to select promising
investments for the Portfolio. In addition, the Adviser rigorously
 
                                       13
<PAGE>
assesses earnings results. Valuation is of secondary importance to the Adviser
and is viewed in the context of prospects for sustainable earnings growth and
the potential for positive earnings surprises in relation to consensus
expectations.
 
    In selecting investments for the Portfolio, the Adviser emphasizes
individual security selection. Overweighted sector positions and issuer
positions may result from the investment process. The Portfolio does not expect
to invest more than 25% of its total assets at the time of purchase in
securities of foreign companies. The Portfolio may invest in securities of
foreign issuers directly or in the form of Depositary Receipts.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
CONVERTIBLE SECURITIES, WARRANTS AND EQUITY-LINKED SECURITIES.
 
    The Portfolios may invest in securities such as convertible securities,
preferred stock, warrants or other securities exchangeable under certain
circumstances for shares of common stock. Warrants are instruments giving
holders the right, but not the obligation, to buy shares of a company at a given
price during a specified period.
 
    The Aggressive Equity Portfolio may invest in equity-linked securities,
including, among others, PERCS, ELKS or LYONs, which are securities that are
convertible into or the value of which is based upon the value of, equity
securities upon certain terms and conditions. The amount received by an investor
at maturity of such securities is not fixed but is based on the price of the
underlying common stock. It is impossible to predict whether the price of the
underlying common stock will rise or fall. Trading prices of the underlying
common stock will be influenced by the issuer's operational results, by complex,
interrelated political, economic, financial, or other factors affecting the
capital markets, the stock exchanges on which the underlying common stock is
traded and the market segment of which the issuer is a part. In addition, it is
not possible to predict how equity-linked securities will trade in the secondary
market, which is fairly developed and liquid. The market for such securities may
be shallow, however, and high volume trades may be possible only with
discounting. In addition to the foregoing risks, the return on such securities
depends on the creditworthiness of the issuer of the securities, which may be
the issuer of the underlying securities or a third party investment banker or
other lender. The creditworthiness of such third party issuer of equity-linked
securities may, and often does, exceed the creditworthiness of the issuer of the
underlying securities. The advantage of using equity-linked securities over
traditional equity and debt securities is that the former are income producing
vehicles that may provide a higher income than the dividend income on the
underlying equity securities while allowing some participation in the capital
appreciation of the underlying equity securities. Another advantage of using
equity-linked securities is that they may be used for hedging to reduce the risk
of investing in the generally more volatile underlying equity securities.
 
    The following are three examples of equity-linked securities. The Portfolio
may invest in the securities described below or other similar equity-linked
securities.
 
    PERCS.  Preferred Equity Redemption Cumulative Stock ("PERCS") technically
is preferred stock with some characteristics of common stock. PERCS are
mandatorily convertible into common stock after a period of time, usually three
years, during which the investors' capital gains are capped, usually at 30%.
Commonly, PERCS may be redeemed by the issuer at any time or if the issuer's
common stock is trading at a specified price level or better. The redemption
price starts at the beginning of the PERCS duration period at a price that is
above the cap by the amount of the extra dividends the PERCS holder is entitled
to receive relative to the
 
                                       14
<PAGE>
common stock over the duration of the PERCS and declines to the cap price
shortly before maturity of the PERCS. In exchange for having the cap on capital
gains and giving the issuer the option to redeem the PERCS at any time or at the
specified common stock price level, the Portfolio may be compensated with a
substantially higher dividend yield than that on the underlying common stock.
Investors, such as the Portfolio, that seek current income find PERCS attractive
because PERCS provide a higher dividend income than that paid with respect to a
company's common stock.
 
    ELKS.  Equity-Linked Securities ("ELKS") differ from ordinary debt
securities, in that the principal amount received at maturity is not fixed but
is based on the price of the issuer's common stock. ELKS are debt securities
commonly issued in fully registered form for a term of three years under an
indenture trust. At maturity, the holder of ELKS will be entitled to receive a
principal amount equal to the lesser of a cap amount, commonly in the range of
30% to 55% greater than the current price of the issuer's common stock, or the
average closing price per share of the issuer's common stock, subject to
adjustment as a result of certain dilution events, for the 10 trading days
immediately prior to maturity. Unlike PERCS, ELKS are commonly not subject to
redemption prior to maturity. ELKS usually bear interest during the three-year
term at a substantially higher rate than the dividend yield on the underlying
common stock. In exchange for having the cap on the return that might have been
received as capital gains on the underlying common stock, the Portfolio may be
compensated with the higher yield, contingent on how well the underlying common
stock does. Investors, such as the Portfolio, that seek current income, find
ELKS attractive because ELKS provide a higher dividend income than that paid
with respect to a company's common stock.
 
    LYONS.  Liquid Yield Option Notes ("LYONs") differ from ordinary debt
securities, in that the amount received prior to maturity is not fixed but is
based on the price of the issuer's common stock. LYONs are zero-coupon notes
that sell at a large discount from face value. For an investment in LYONs, the
Portfolio will not receive any interest payments until the notes mature,
typically in 15 to 20 years, when the notes are redeemed at face, or par, value.
The yield on LYONs, typically, is lower-than-market rate for debt securities of
the same maturity, due in part to the fact that the LYONs are convertible into
common stock of the issuer at any time at the option of the holder of the LYONs.
Commonly, the LYONs are redeemable by the issuer at any time after an initial
period or if the issuer's common stock is trading at a specified price level or
better or, at the option of the holder, upon certain fixed dates. The redemption
price typically is the purchase price of the LYONs plus accrued original issue
discount to the date of redemption, which amounts to the lower-than-market
yield. The Portfolio will receive only the lower-than-market yield unless the
underlying common stock increases in value at a substantial rate. LYONs are
attractive to investors like the Portfolio when it appears that they will
increase in value due to the rise in value of the underlying common stock.
 
    DEPOSITARY RECEIPTS.  The Portfolios may invest in Depositary Receipts,
including American Depositary Receipts ("ADRs"), Global Depositary Receipts
("GDRs"), European Depositary Receipts ("EDRs") and other Depositary Receipts
(which, together with ADRs, GDRs and EDRs, are hereinafter collectively referred
to as "Depositary Receipts"), to the extent that such Depositary Receipts are or
become available. ADRs are securities, typically issued by a U.S. financial
institution (a "depositary"), that evidence ownership interests in a security or
a pool of securities issued by a foreign issuer (the "underlying issuer") and
deposited with the depositary. ADRs may be "sponsored" or "unsponsored."
Sponsored ADRs are established jointly by a depositary and the underlying
issuer, whereas unsponsored ADRs may be established by a depositary without
participation by the underlying issuer. The issuers of the stock of unsponsored
ADRs are not obligated to disclose material information in the United States and
therefore, there may not be a correlation between such
 
                                       15
<PAGE>
information and the market value of the ADR. GDRs, EDRs and other types of
Depositary Receipts are typically issued by foreign depositaries, although they
may also be issued by U.S. depositaries, and evidence ownership interests in a
security or pool of securities issued by either a foreign or a U.S. corporation.
Generally, Depositary Receipts in registered form are designed for use in the
U.S. securities market and Depositary Receipts in bearer form are designed for
use in securities markets outside the United States. The Portfolios may invest
in sponsored and unsponsored Depositary Receipts. For purposes of the
Portfolios' investment policies, the Portfolios' investments in Depositary
Receipts will be deemed to be investments in the underlying securities.
 
    FIXED INCOME SECURITIES.  The Emerging Growth Portfolio may invest in fixed
income (debt) securities. The market value of the fixed income securities in
which a Portfolio invests will be affected by changes in the creditworthiness of
issuers and will change in response to interest rate changes and other factors.
Generally, the values of fixed income securities vary inversely with changes in
interest rates, so that during periods of falling interest rates, the values of
outstanding fixed income securities generally rise and during periods of rising
interest rates, the values of such securities generally decline. While
securities with longer maturities tend to produce higher yields, the prices of
longer maturity securities are subject to greater market fluctuations as a
result of changes in interest rates.
 
    FOREIGN CURRENCY FORWARD CONTRACTS.  Each Portfolio may enter into foreign
currency forward contracts ("forward contracts") that provide for the purchase
or sale of an amount of a specified currency at a future date. The Portfolios
may use such contracts to protect against a decline in a foreign currency
against the U.S. dollar between the trade date and settlement date when the
Portfolio purchases or sells securities, lock in the U.S. dollar value of
dividends and interest on securities held by the Portfolio, and generally to
protect the U.S. dollar value of securities held by the Portfolio against
exchange rate fluctuation. While forward contracts may limit losses as a result
of exchange rate fluctuations, they will also limit any gains that might
otherwise have been realized. The Portfolio's Custodian may be required to place
cash or liquid securities in a segregated account in an amount equal to the
value of the Portfolio's total assets committed to the consummation of forward
contracts. If the value of the securities placed in the segregated account
declines, additional cash or securities will be placed in the account on a daily
basis so that the value of the account will be at least equal to the amount of
the Portfolio's commitments with respect to such contracts.
 
    FOREIGN INVESTMENT.  Each Portfolio may invest in the securities of foreign
issuers. Investment in securities of foreign issuers involves investment risks
somewhat different from those affecting securities of U.S. issuers. The
Portfolio's investments will be subject to political and economic events that
affect the countries in which it invests. Foreign issuers may be subject to
different accounting, auditing and financial standards and requirements. There
also may be less government supervision and regulation of foreign securities
exchanges, brokers and listed companies than in the United States. Many foreign
securities markets have substantially less trading volume than U.S. national
securities exchanges and, therefore, securities of some foreign issuers are less
liquid and more volatile than securities of comparable U.S. issuers. Brokerage
commissions and other transaction costs on foreign securities exchanges are
generally higher than in the United States. Dividends and interest paid by
foreign issuers may be subject to withholding and other foreign taxes, which may
decrease the net return on foreign investments as compared to dividends and
interest paid to the Portfolios by domestic companies. Investments in securities
of foreign issuers are generally denominated in foreign currencies and, since a
 
                                       16
<PAGE>
Portfolio may temporarily hold uninvested reserves in bank deposits in foreign
currencies, the value of a Portfolio's assets as measured in U.S. dollars may be
affected favorably or unfavorably by changes in currency exchange rates and
exchange control regulations, and a Portfolio may incur costs in connection with
conversions between various currencies.
 
    LOANS OF PORTFOLIO SECURITIES.  The Portfolios may lend their securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing net investment income. These loans must be secured
continuously by cash or equivalent collateral, or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be a risk of delay in recovery of the securities or even loss
of rights in the collateral should the borrower of the securities fail
financially. A Portfolio will not enter into securities loan transactions
exceeding, in the aggregate, 33 1/3% of the market value of its total assets.
 
    MONEY MARKET INSTRUMENTS.  Each Portfolio is permitted to invest in money
market instruments, although the Portfolios intend to stay invested in
securities satisfying their primary investment objective to the extent
practical. Consistent with their investment policies, the Portfolios may make
money market investments pending other investment or settlement for liquidity.
In addition, the Portfolios may invest in money market instruments for temporary
defensive purposes during adverse market conditions. The money market
investments permitted for the Portfolios include: obligations of the U.S.
Government and its agencies and instrumentalities, commercial paper, bank
obligations (including certificates of deposit), other debt securities and
repurchase agreements.
 
    NON-PUBLICLY TRADED SECURITIES, PRIVATE PLACEMENTS AND RESTRICTED
SECURITIES.  The Equity Growth and Aggressive Equity Portfolios may invest in
securities that are neither listed on a stock exchange nor traded
over-the-counter. Such unlisted equity securities may involve a higher degree of
business and financial risk that can result in substantial losses. As a result
of the absence of a public trading market for these securities, they may be less
liquid than publicly traded securities. Although these securities may be resold
in privately negotiated transactions, the prices realized from these sales could
be less than those originally paid by the Portfolios or less than what may be
considered the fair value of such securities. Further, companies whose
securities are not publicly traded may not be subject to the disclosure and
other investor protection requirements which might be applicable if their
securities were publicly traded. If such securities are required to be
registered under the securities laws of one or more jurisdictions before being
resold, the Portfolio may be required to bear the expenses of registration.
 
    As a general matter, a Portfolio may not invest more than 15% of its net
assets in illiquid securities, including securities for which there is no
readily available secondary market. Securities that are not registered under the
Securities Act of 1933, as amended, but that can be offered and sold to
qualified institutional buyers under Rule 144A under that Act ("Rule 144A
Securities") will not be included within the foregoing 15% restriction if the
securities are determined to be liquid. The Board of Directors has adopted
guidelines and delegated to the Adviser, subject to the supervision of the Board
of Directors, the daily function of determining and monitoring the liquidity of
Rule 144A Securities. Rule 144A Securities may become illiquid if qualified
institutional buyers are not interested in acquiring the securities.
 
                                       17
<PAGE>
    REPURCHASE AGREEMENTS.  The Portfolios may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines established by
the Fund's Board of Directors. In a repurchase agreement, the Portfolio buys a
security from a seller that has agreed to repurchase it at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of the
agreement. The term of these agreements is usually from overnight to one week,
and never exceeds one year. A repurchase agreement may be viewed as a fully
collateralized loan of money by the Portfolio to the seller. The Portfolio
always receives securities, with a market value at least equal to the purchase
price (including accrued interest) as collateral and this value is maintained
during the term of the agreement. If the seller defaults and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with respect to the seller, the Portfolio's realization upon the
collateral may be delayed or limited. The Portfolios may not enter into
repurchase agreements with more than seven days to maturity if, as a result,
more than 15% of the market value of the Portfolio's net assets are invested in
these agreements and other investments for which market quotations are not
readily available or which are otherwise illiquid.
 
    SHORT SALES.  The Aggressive Equity Portfolio may from time to time sell
securities short consistent with applicable legal requirements. A short sale is
a transaction in which the Portfolio sells securities it either owns or has the
right to acquire at no added cost (i.e., "against the box") or does not own (but
has borrowed) in anticipation of a decline in the market price of the
securities. To deliver the securities to the buyer, the Portfolio arranges
through a broker to borrow the securities and, in so doing, the Portfolio will
become obligated to replace the securities borrowed at their market price at the
time of the replacement, whatever that price may be. When the Portfolio makes a
short sale of borrowed securities, the proceeds it receives from the sale will
be held on behalf of a broker until the Portfolio replaces the borrowed
securities. The Portfolio may have to pay a premium to borrow the securities and
must pay any dividends or interest payable on the securities until they are
replaced.
 
    The Portfolio's obligation to replace the securities borrowed in connection
with a short sale will be secured by collateral deposited with the broker that
consists of cash or other liquid securities. In addition, if the short sale is
not "against the box", the Portfolio will place in a segregated account with the
Custodian an amount of cash or other liquid securities equal to the difference,
if any, between (i) the market value of the securities sold at the time they
were sold short, and (ii) any cash or other liquid securities deposited as
collateral with the broker in connection with the short sale. Short sales by the
Portfolio involve certain risks and special considerations. Possible losses from
short sales differ from losses that could be incurred from a purchase of a
security, because losses from short sales may be unlimited, whereas losses from
purchases can equal only the total amount invested.
 
    SMALL- AND MEDIUM-SIZED COMPANIES.  The Emerging Growth Portfolio seeks
long-term capital appreciation by investing primarily in small- to medium-sized
companies, which generally are more vulnerable to financial and other risks than
larger, more established companies. Accordingly, investments in this Portfolio
may involve a higher degree of risk and price volatility than the general equity
markets. The Aggressive Equity Portfolio may invest in small- to medium-sized
companies to a lesser extent.
 
    TEMPORARY INVESTMENTS.  During periods in which the Adviser believes changes
in economic, financial or political conditions make it advisable, each Portfolio
may, for temporary defensive purposes, invest up to 100% of its total assets in
certain short-term and medium-term debt obligations or hold cash. The short-term
and
 
                                       18
<PAGE>
medium-term debt obligations in which a Portfolio may invest consist of (i)
obligations of the U.S. or foreign governments, their respective agencies or
instrumentalities; (ii) money market instruments; and (iii) instruments
denominated in any currency issued by international development agencies.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  The Portfolios may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Delivery of and payment for these securities may take
as long as a month or more after the date of the purchase commitment, but will
take place no more than 120 days after the trade date. The Portfolio will
maintain with the Custodian a segregated account of cash or liquid securities in
an amount at least equal to these commitments. The payment obligation and the
interest rates that will be received are each fixed at the time a Portfolio
enters into the commitment and no interest accrues to the Portfolio until
settlement. Thus, it is possible that the market value at the time of settlement
could be higher or lower than the purchase price if the general level of
interest rates has changed. It is a current policy of the Portfolios not to
enter into when-issued commitments exceeding in the aggregate 15% of the
Portfolio's net assets other than the obligations created by these commitments.
 
DERIVATIVE PRODUCTS (DERIVATIVES)
 
    The Portfolios are permitted to utilize various exchange-traded and
over-the-counter derivative instruments and derivative securities, both for
hedging and non-hedging purposes. Permitted derivative products include, but are
not limited to: futures contracts ("futures"); forward contracts ("forwards");
options; swaps, caps, collars and floors; structured notes; and other derivative
products yet to be developed, so long as these new products are used in a manner
consistent with the objectives of the Portfolios. These derivative products may
be based upon a wide variety of underlying rates, indices, instruments,
securities and other products, such as interest rates, foreign currencies,
foreign and domestic fixed income and equity securities, groups or "baskets" of
securities and securities indices (for each derivative product, the
"underlying"). Exclusive of forward foreign currency contracts and any
derivative products used for hedging purposes, each Portfolio will limit its use
of derivative products to 33 1/3% of its total assets, measured by the aggregate
notional amount of outstanding derivative products.
 
    The Portfolios may use derivative products under a number of different
circumstances to further their investment objectives. For example, a Portfolio
may purchase derivatives to gain exposure to a market quickly in response to
changes in the Portfolio's investment strategy, upon the inflow of investable
cash or when the derivative provides greater liquidity than the underlying
market. A Portfolio may also use derivatives when it is restricted from directly
owning the "underlying" or when derivatives provide a pricing advantage or lower
transaction costs. The Portfolios also may purchase combinations of derivatives
in order to gain exposure to an investment in lieu of actually purchasing such
investment. Derivatives may also be used by a Portfolio for hedging or risk
management purposes and in other circumstances when the Adviser believes it
advantageous to do so consistent with the Portfolio's investment objectives and
policies. The Portfolios will not use derivatives in a manner that creates
leverage, except to the extent that the use of leverage is expressly permitted
by a particular Portfolio's investment policies, and then only in a manner
consistent with such policies.
 
                                       19
<PAGE>
    The use of derivative products is a highly specialized activity which
involves investment techniques and risks different from those associated with
ordinary portfolio securities transactions. If the Adviser is incorrect in
forecasts of market values, interest rates, and currency exchange rates, the
investment performance of the Portfolios will be less favorable than it would
have been if these investment techniques had not been used.
 
    Some of the derivative products in which the Portfolios may invest and some
of the risks related thereto are described in more detail below.
 
FUTURES CONTRACTS (FUTURES) AND FORWARD CONTRACTS (FORWARDS)
 
    The Portfolios may purchase and sell futures contracts, such as futures on
securities indices, baskets of securities, foreign currencies and interest rates
of the type generally known as financial futures. These are standardized
contracts that are bought and sold on organized exchanges. A futures contract
obligates a party to buy or sell a specific amount of the "underlying," such as
for example, a particular foreign currency, on a specified future date at a
specified price or to settle the value in cash.
 
    The Portfolios may also purchase and sell forward contracts, such as forward
rate agreements and other financial forward contracts. The Portfolios may also
use foreign currency forward contracts which are separately discussed elsewhere
in this Prospectus. See "Foreign Currency Forward Contracts" above. These
forward contracts are privately negotiated and are bought and sold in the
over-the-counter market. Like a future, a forward contract obligates a party to
buy or sell a specific amount of the underlying on a specified future date at a
specified price. The terms of the forward contract are customized. Forward
contracts, like other over-the-counter contracts that are negotiated directly
with an individual counterparty, subject the Portfolio to the risk of
counterparty default.
 
    In some cases, the Portfolios may be able to use either futures contracts,
forward contracts or exchange-traded or over-the-counter options to accomplish
similar purposes. In all cases, the Portfolios will use these products only as
permitted by applicable laws and regulations. Some of the ways in which the
Portfolios may utilize futures contracts, forward contracts and related options
are as follows:
 
    The Portfolios may sell securities index futures contracts and/or index
options thereon in anticipation of or during a market decline to attempt to
offset the decrease in market value of investments in its portfolio, or may
purchase securities index futures or options in order to gain market exposure.
There currently are limited securities index futures and options on such futures
in many countries, particularly emerging countries. The nature of the strategies
adopted by the Adviser, and the extent to which those strategies are used, may
depend on the development of such markets. The Portfolios may also purchase and
sell foreign currency futures to hedge their respective holdings and commitments
against changes in the level of future currency rates or to adjust their
exposure to a particular currency.
 
    The Portfolios may engage in transactions in interest rate futures and
related products. The value of these contracts rises and falls inversely with
changes in interest rates. The Portfolios may engage in such transactions to
hedge their holdings of debt instruments against future changes in interest
rates or for other purposes.
 
    The Portfolios may also purchase or sell futures and forwards on other
financial instruments, such as U.S. Government securities and certificates of
deposit. The value of these contracts also rises and falls inversely with
changes in interest rates. The Portfolios may engage in financial futures and
forward contracts for both hedging and non-hedging purposes.
 
                                       20
<PAGE>
    Gains and losses on futures contracts, forward contracts and related options
depend on the Adviser's ability to predict correctly the direction of securities
prices, interest rates and other economic factors. Other risks associated with
the use of these instruments include (i) imperfect correlation between the
change in market value of investments held by a Portfolio and the prices of
derivative products relating to investments purchased or sold by the Portfolio,
and (ii) possible lack of a liquid secondary market for a derivative product and
the resulting inability to close out a position. The risk that a Portfolio will
be unable to close out a position will be minimized by only entering into
transactions for which there appears to be a liquid exchange or secondary
market. In some strategies, the risk of loss in trading on futures and related
transactions can be substantial, due both to the low margin deposits required
and the extremely high degree of leverage involved in pricing.
 
    Under rules adopted by the Commodity Futures Trading Commission (the
"CFTC"), each Portfolio may, without registering with the CFTC as a Commodity
Pool Operator, enter into futures contracts and options thereon for both hedging
and non-hedging purposes, provided that not more than 5% of such Portfolio's
total assets at the time of entering the transaction are required as margin and
option premiums to secure obligations under such contracts relating to non-bona
fide hedging activities.
 
OPTION TRANSACTIONS
 
    The Portfolios may seek to increase their returns or may hedge their
portfolio investments through options transactions with respect to individual
securities, indices or baskets in which such Portfolios may invest; other
financial instruments; and foreign currency. Various options may be purchased
and sold on either the exchange-traded or over-the-counter markets.
 
    Each Portfolio may purchase put and call options. Purchasing a put option
gives a Portfolio the right, but not the obligation, to sell the underlying
(such as a securities index or a particular foreign currency) at the exercise
price either on a specific date or during a specified exercise period.
Purchasing a call option gives a Portfolio a similar right, but not the
obligation, to purchase the underlying. The purchaser pays a premium to the
seller (also known as the writer) of the option.
 
    Each Portfolio also may write put and call options on investments held in
its portfolio, as well as foreign currency options. A Portfolio that has written
an option receives a premium that increases the Portfolio's return on the
underlying in the event the option expires unexercised or is closed out at a
profit. However, by writing a call option, a Portfolio will limit its
opportunity to profit from an increase in the market value of the underlying
above the exercise price of the option. By writing a put option, a Portfolio
will be exposed to the amount by which the price of the underlying is less than
the strike price.
 
    By writing an option, a Portfolio incurs an obligation either to buy (in the
case of a put option) or sell (in the case of a call option) the underlying from
the purchaser of the option at the option's exercise price, upon exercise by the
purchaser. Pursuant to guidelines established by the Board of Directors, the
Portfolios may only write options that are "covered." A covered call option
means that until the expiration of the option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will continue to own (i) the underlying; (ii) securities or instruments
convertible or exchangeable without the payment of any consideration into the
underlying; or (iii) a call option on the same underlying with a strike price no
higher than the price at which the underlying was sold pursuant to a short
option position. In the case of a put option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will own another put option on the same underlying with an equal or higher
strike price.
 
                                       21
<PAGE>
    There currently are limited options markets in many countries, particularly
emerging market countries, and the nature of the strategies adopted by the
Adviser and the extent to which those strategies are used will depend on the
development of these options markets. The primary risks associated with the
Portfolios' use of options as described include (i) imperfect correlation
between the change in market value of investments held, purchased or sold by a
Portfolio and the prices of options relating to such investments, and (ii)
possible lack of a liquid secondary market for an option.
 
INTEREST RATE, CURRENCY, COMMODITY AND EQUITY SWAPS, CAPS, COLLARS AND FLOORS
 
    Swaps are privately negotiated over-the-counter derivative products in which
two parties agree to exchange payment streams calculated in relation to a rate,
index, instrument or certain securities and a particular "notional amount." As
with many of the other derivative products available to the Portfolios, the
underlying may include an interest rate (fixed or floating), a currency exchange
rate, a commodity price index, and a security, securities index or a combination
thereof. A great deal of flexibility is possible in the way the products may be
structured, with the effect being that the parties may have exchanged amounts
equal to the return on one rate, index or group of securities for another. For
example, in a simple fixed-to-floating interest rate swap, one party makes
payments equivalent to a fixed interest rate, and the other makes payments
equivalent to a specified interest rate index. A Portfolio may engage in simple
or more complex swap transactions involving a wide variety of underlyings. The
currency swaps that the Portfolios may enter will generally involve an agreement
to pay interest streams in one currency based on a specified index in exchange
for receiving interest streams denominated in another currency. Such swaps may
involve initial and final exchanges that correspond to the agreed upon notional
amount.
 
    Caps, collars and floors are privately-negotiated option-based derivative
products. A Portfolio may use one or more of these products in addition to or in
lieu of a swap involving a similar rate or index. As in the case of a put or
call option, the buyer of a cap or floor pays a premium to the writer. In
exchange for that premium, the buyer receives the right to a payment equal to
the differential if the specified index or rate rises above (in the case of a
cap) or falls below (in the case of a floor) a pre-determined strike level. As
in the case of swaps, obligations under caps and floors are calculated based
upon an agreed notional amount, and like most swaps (other than foreign currency
swaps), the entire notional amount is not exchanged and thus is not at risk. A
collar is a combination product in which the same party, such as the Portfolio,
buys a cap from and sells a floor to the other party. As with put and call
options, the amount at risk is limited for the buyer, but, if the cap or floor
is not hedged or covered, may be unlimited for the seller. Under current market
practice, caps, collars and floors between the same two parties are generally
documented under the same "master agreement." In some cases, options and forward
agreements may also be governed by the same master agreement. In the event of a
default, amounts owed under all transactions entered into under, or covered by,
the same master agreement would be netted and only a single payment would be
made.
 
    Swaps, caps, collars and floors are credit-intensive products. A Portfolio
that enters into a swap transaction bears the risk of default, i.e. nonpayment,
by the other party. The guidelines under which each Portfolio enters derivative
transactions, along with some features of the transactions themselves, are
intended to reduce these risks to the extent reasonably practicable, although
they cannot eliminate the risks entirely. Under guidelines established by the
Board of Directors, a Portfolio may enter into swaps only with parties that meet
certain credit rating guidelines. Consistent with current market practices, a
Portfolio will generally enter into swap transactions on a net basis, and all
swap transactions with the same party will be documented under a single master
 
                                       22
<PAGE>
agreement to provide for net payment upon default. In addition, a Portfolio's
obligations under an agreement will be accrued daily (offset against any amounts
owing to the Portfolio) and any accrued, but unpaid, net amounts owed to the
other party to a master agreement will be covered by the maintenance of a
segregated account consisting of cash or liquid securities.
 
    Interest rate and total rate of return (fixed income or equity) swaps
generally do not involve the delivery of securities, other underlying assets, or
principal. In such case, if the other party to an interest rate or total rate of
return swap defaults, a Portfolio's risk of loss will consist of the payments
that a Portfolio is contractually entitled to receive from the other party. This
may not be true for currency swaps that require the delivery of the entire
notional amount of one designated currency in exchange for the other. If there
is a default by the other party, a Portfolio may have contractual remedies
pursuant to the agreements related to the transaction.
 
STRUCTURED NOTES
 
    Structured notes are derivative securities for which the amount of principal
repayment and/or interest payments is based upon the movement of one or more
factors. These factors include, but are not limited to, currency exchange rates,
interest rates (such as the prime lending rate and LIBOR) and stock indices,
such as the S&P 500. In some cases, the impact of the movements of these factors
may increase or decrease through the use of multipliers or deflators. The
Portfolios may use structured notes to tailor their investments to the specific
risks and returns the Adviser wishes to accept while avoiding or reducing
certain other risks.
 
                             INVESTMENT LIMITATIONS
 
    Each of the Equity Growth and Emerging Growth Portfolios is a diversified
investment company and is therefore subject to the following fundamental
limitations: (i) as to 75% of its total assets, a Portfolio may not invest more
than 5% of its total assets in the securities of any one issuer, except
obligations of the U.S. Government and its agencies and instrumentalities, and
(ii) a Portfolio may not own more than 10% of the outstanding voting securities
of any one issuer.
 
    The Aggressive Equity Portfolio is a non-diversified portfolio under the
Investment Company Act of 1940, as amended (the "1940 Act"), which means that
the Portfolio is not limited by the 1940 Act in the proportion of its assets
that may be invested in the obligations of a single issuer. Thus, the Portfolio
may invest a greater proportion of its assets in the securities of a small
number of issuers and as a result will be subject to greater risk with respect
to its portfolio securities. Nevertheless, the Portfolio intends to comply with
more limited diversification requirements imposed by the Internal Revenue Code
of 1986, as amended (the "Code"), for qualification as a regulated investment
company.
 
    Each Portfolio also operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of the
holders of a majority of such Portfolio's outstanding shares and under certain
non-fundamental investment limitations that may be changed without shareholder
approval. For additional information on fundamental and non-fundamental
investment limitations, see "Investment Limitations" in the Statement of
Additional Information.
 
                                       23
<PAGE>
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and each Portfolio. The Adviser provides investment
advice and portfolio management services, pursuant to an Investment Advisory
Agreement and, subject to the supervision of the Fund's Board of Directors,
makes each of the Portfolio's day-to-day investment decisions, arranges for the
execution of portfolio transactions and generally manages each of the
Portfolio's investments. Set forth below as an annual percentage of average
daily net assets are the management fees payable to the Adviser quarterly by
each Portfolio pursuant to the terms of the Investment Advisory Agreement. The
fees for the Emerging Growth and Aggressive Equity Portfolios are higher than
most investment companies because each of the Portfolios invests
internationally. The Adviser believes that the fees are comparable to those of
other investment companies that invest internationally. The Adviser has
voluntarily agreed to a reduction in the fees payable to it and to reimburse the
Portfolios, if necessary, if such fees would cause the total annual operating
expenses of the Portfolios to exceed the maximums set forth below.
 
<TABLE>
<CAPTION>
                                                                  MAXIMUM TOTAL OPERATING
                                                                     EXPENSES AFTER FEE
                                                                           WAIVER
                                                                  ------------------------
PORTFOLIO                                       MANAGEMENT FEE      CLASS A      CLASS B
- ---------------------------------------------  -----------------  -----------  -----------
<S>                                            <C>                <C>          <C>
Equity Growth Portfolio                                0.60%           0.80%        1.05%
Emerging Growth Portfolio                              1.00%           1.25%        1.50%
Aggressive Equity Portfolio                            0.80%           1.00%        1.25%
</TABLE>
 
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to customers in the
United States and abroad. Morgan Stanley Dean Witter & Co. ("MSDW") is the
direct parent of the Adviser and Morgan Stanley. MSDW is a preeminent global
financial services firm that maintains leading market positions in each of its
three primary businesses -- securities, asset management and credit services. At
March 31, 1998, the Adviser, together with its affiliated asset management
companies, managed assets of approximately $166 billion, including assets under
fiduciary advice. See "Management of the Fund" in the Statement of Additional
Information.
 
    PORTFOLIO MANAGERS.  The following persons have primary responsibility for
managing the Portfolios indicated.
 
    EQUITY GROWTH PORTFOLIO -- KURT A. FEUERMAN AND MARGARET K. JOHNSON.  Kurt
A. Feuerman joined the Adviser in July 1993 as a Managing Director in the
Institutional Equity Group. Previously Mr. Feuerman was a Managing Director of
Morgan Stanley's Research Department, where he was responsible for emerging
growth stocks, gaming and restaurants. Mr. Feuerman earned an M.B.A. from
Columbia University in 1982, an M.A. from Syracuse University in 1980, and a
B.A. from McGill University in 1977. Margaret K. Johnson is a Principal of the
Adviser and Morgan Stanley and a Portfolio Manager in the Institutional Equity
Group. She joined the Adviser in 1984. She holds a B.A. degree from Yale College
and is a Chartered Financial Analyst. Mr. Feuerman and Ms. Johnson have had
primary responsibility for managing the Portfolio's assets since July 1993 and
April 1991, respectively.
 
                                       24
<PAGE>
    EMERGING GROWTH -- KURT A. FEUERMAN AND DANIEL R. LASCANO.  Information
about Mr. Feuerman is included under the Equity Growth Portfolio above. Daniel
R. Lascano is a Vice President of the Adviser and Morgan Stanley. He joined the
Adviser in 1993 as an equity analyst. Prior to joining the Adviser, Mr. Lascano
worked at Morgan Stanley as a research assistant to Kurt Feuerman. Mr. Lascano
graduated from the University of California at Berkeley with a B.A. in Economics
and Statistics.
 
    AGGRESSIVE EQUITY PORTFOLIOS -- KURT A. FEUERMAN.  Information about Mr.
Feuerman is included under the Equity Growth Portfolio above.
 
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the officers and the
Board of Directors of the Fund and include day-to-day administration of matters
related to the corporate existence of the Fund, maintenance of its records,
preparation of reports, supervision of the Fund's arrangements with its
custodian, and assistance in the preparation of the Fund's registration
statements under federal laws. The Administration Agreement also provides that
the Administrator, through its agents, will provide dividend disbursing and
transfer agent services to the Fund. For its services under the Administration
Agreement, the Fund pays the Adviser a monthly fee which on an annual basis
equals 0.15% of the average daily net assets of each Portfolio.
 
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors such administrative services provided by CGFSC.
Their services are also subject to the supervision of the Board of Directors of
the Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of each Portfolio upon the terms and at the current
offering price described in this Prospectus. Morgan Stanley is not obligated to
sell any certain number of shares of any Portfolio.
 
    The Portfolios currently offer only the classes of shares offered by this
Prospectus. The Portfolios may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares of each Portfolio pursuant to Rule 12b-1 under the 1940 Act (each, a
"Plan"). Under each Plan, the Distributor is entitled to receive from each
Portfolio a distribution fee, which is accrued daily and paid quarterly, of
0.25% of the Class B shares' average daily net assets on an annualized basis.
Each Plan is designed to compensate the Distributor for its services in
connection with distribution assistance. The Distributor may retain any portion
of the fee that it does not expend in meeting its obligations to the Fund. The
Distributor may compensate financial intermediaries, plan fiduciaries and
administrators for providing distribution-related services, including account
maintenance services, to shareholders (including, where applicable, underlying
beneficial owners) of Class B shares.
 
                                       25
<PAGE>
    EXPENSES.  Each Portfolio is responsible for payment of certain other fees
and expenses (including legal fees, accountants' fees, custodial fees, and
printing and mailing costs) as specified in its agreements with the Adviser and
Morgan Stanley.
 
    YEAR 2000.  The management and distribution services provided to the Fund by
the Adviser and Morgan Stanley depend on the smooth functioning of their
computer systems. Many computer software systems in use today cannot recognize
the year 2000, but revert to 1900 or some other date, due to the manner in which
dates were encoded and calculated. That failure could have a negative impact on
the handling of securities trades, pricing and account services. The Adviser and
Morgan Stanley have been actively working on necessary changes to their own
computer systems to deal with the year 2000 problem and expect that their
systems will be adapted before that date. There can be no assurance, however,
that they will be successful. In addition, other unaffiliated service providers
may be faced with similar problems. The Adviser and Morgan Stanley are
monitoring their remedial efforts, however, there can be no assurance that they
and the services they provide will not be adversely affected.
 
    In addition, it is possible that the markets for securities in which the
Portfolios invest may be detrimentally affected by computer failures throughout
the financial services industry beginning January 1, 2000. Improperly
functioning trading systems may result in settlement problems and liquidity
issues. In addition, corporate and governmental data processing errors may
result in production problems for individual companies and overall economic
uncertainties. Earnings of individual issuers will be affected by remediation
costs, which may be substantial and may be reported inconsistently in U.S. and
foreign financial statements. Accordingly, the Portfolios' investments may be
adversely affected.
 
                               PURCHASE OF SHARES
 
    Class A shares of each Portfolio and Class B shares of each Portfolio may be
purchased at the net asset value per share next determined after receipt by the
Fund of a purchase order as described under "Methods of Purchase." The net asset
value per share of each Portfolio is calculated on days that the New York Stock
Exchange ("NYSE") and Chase (the "Custodian Bank") are open for business as of
the close of trading of the NYSE, normally 4:00 p.m. Eastern Time (the "Pricing
Time").
 
MINIMUM INVESTMENT
 
    The minimum initial investment is $500,000 for Class A shares and $100,000
for Class B shares of each Portfolio. These minimums may be waived at the
discretion of the Adviser for certain types of investors, including trust
departments, brokers, dealers, agents, financial planners, financial services
firms, investment advisers or various retirement and deferred compensation plans
("Financial Intermediaries"), certain accounts managed by the Adviser and its
affiliates ("Managed Accounts"), and certain employees and customers of Morgan
Stanley and its affiliates. The Fund's determination of an investor's
eligibility to purchase shares of a given class will take precedence over the
investor's selection of a class.
 
METHODS OF PURCHASE
 
    Shares may be purchased directly from the Fund by Federal Funds wire, by
bank wire or by check. Investors may also invest in the Portfolios by purchasing
shares through Financial Intermediaries that have made arrangements with Morgan
Stanley. Some Financial Intermediaries may charge an additional service or
transaction fee. If a purchase is canceled due to nonpayment or because your
check does not clear, you will be
 
                                       26
<PAGE>
responsible for any loss the Fund or its agents incur. If you are already a
shareholder, the Fund may redeem shares from your account(s) to reimburse the
Fund or its agents for any loss. In addition, you may be prohibited or
restricted from making future investments in the Fund.
 
    FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire Federal
Funds to the Fund's bank account. Federal Funds purchase orders will be accepted
only on a day on which the Fund and the Custodian Bank are open for business.
Your bank may charge a service fee for wiring Federal Funds. In order to ensure
proper handling of your purchase by Federal Funds wire, please follow these
steps:
 
    1.    Place your order by telephoning the Fund at 1-800-548-7786. A Fund
          representative will request certain purchase information and provide
          you with a confirmation number.
 
    2.    Instruct your bank to wire the specified amount to the Fund's Wire
          Concentration Bank Account as follows:
 
          The Chase Manhattan Bank
       One Manhattan Plaza
       New York, NY 10081-1000
       ABA# 021000021
       DDA# 910-2-733293
       Attn: Morgan Stanley Institutional Fund, Inc.
       Ref: (Portfolio name, your account number, your account name)
 
          Please call the Fund at 1-800-548-7786 prior to wiring the funds.
 
    3.    Complete and sign the Account Registration Form and mail it to the
          address shown thereon.
 
    When a purchase order is received prior to the Pricing Time and Federal
Funds are received prior to the close of the Federal Funds Wire Control Center
("FFWCC") (normally 6:00 p.m. Eastern Time), the purchase will be executed at
the net asset value computed on the date of receipt. Purchases for which an
order is received after the Pricing Time or for which Federal Funds are received
after the close of the FFWCC, will be executed at the net asset value next
determined. Certain institutional investors and financial institutions have
entered into an arrangement with Morgan Stanley, pursuant to which they may
place orders prior to the Pricing Time, but make payment in Federal Funds for
those shares on the following business day.
 
    BANK WIRE.  A purchase of shares by bank wire must follow the same procedure
as for a Federal Funds wire, described above. However, depending on the time the
bank wire is sent and which bank is handling the wire, money transferred by bank
wire may or may not be converted into Federal Funds prior to the close of the
FFWCC. Prior to conversion to Federal Funds and receipt by the Fund, an
investor's money will not be invested.
 
    CHECK.  An account may be opened by completing and signing an Account
Registration Form and mailing it, together with a check payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio name]" to:
 
    Morgan Stanley Institutional Fund, Inc.
    P.O. Box 2798
    Boston, Massachusetts 02208-2798
 
                                       27
<PAGE>
    The Fund ordinarily is credited with Federal Funds within one business day
of deposit of a check. Thus, a purchase of shares by check ordinarily will be
credited to your account at the net asset value per share of each of the
Portfolios determined on the next business day after receipt. An investor's
money will not be invested prior to crediting of Federal Funds.
 
    INVESTMENT THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to receive purchase and
redemption orders from underlying beneficial owners, such as retirement plan
participants, generally on each business day. Each business evening, the
Financial Intermediary aggregates all orders received from underlying beneficial
owners prior to the Pricing Time on that business day and places a net purchase
and/or redemption order(s) by the morning of the next business day. These orders
normally are executed at the net asset value that was computed for each
Portfolio as of the close of the previous business day.
 
    ADDITIONAL INVESTMENTS.  You may purchase additional shares for your account
at any time by purchasing shares at net asset value by any of the methods
described above. The minimum additional investment generally is $1,000 per
Portfolio. The minimum additional investment may be lower for certain accounts,
described above under "Minimum Investment." For purchases directly from the
Fund, your account name, the Portfolio name and the class selected must be
specified in the letter or wire to assure proper crediting to your account.
 
INVOLUNTARY CONVERSION AND REDEMPTION OF NEW ACCOUNT SHARES
 
    Class A and Class B shares of each Portfolio may be subject to the
involuntary conversion and redemption features described below. The conversion
and redemption features may be waived at the discretion of the Adviser for
shares held in a Managed Account and shares purchased through a Financial
Intermediary. Accounts that were open prior to January 2, 1996 are not subject
to involuntary conversion or redemption. The Fund reserves the right to modify
or terminate the conversion or redemption features of the shares at any time
upon 60 days notice to shareholders.
 
    CONVERSION FROM CLASS A TO CLASS B SHARES.  If the value of an account
containing Class A shares falls below $500,000 (but remains at or above
$100,000) because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $500,000 (but remains at or
above $100,000) for a continuous 60-day period, the Class A shares in such
account will convert to Class B shares and will be subject to the distribution
fee and other features applicable to Class B shares. The Fund will not convert
Class A shares to Class B shares based solely upon changes in the market that
reduce the net asset value of shares. Under current tax law, conversion between
share classes is not a taxable event to the shareholder.
 
    CONVERSION FROM CLASS B TO CLASS A SHARES.  If the value of an account
containing Class B shares increases to $500,000 or more, whether due to
shareholder purchases or market activity, the Class B shares will convert to
Class A shares. Class B shares purchased through a Financial Intermediary that
has entered into an arrangement with the Fund for the purchase of such shares
may not be converted. Under current tax law, such conversion is not a taxable
event to the shareholder. Class A shares converted from Class B shares are
subject to the same minimum account size requirements as are applicable to New
Accounts containing Class A shares described above.
 
                                       28
<PAGE>
    INVOLUNTARY REDEMPTION OF SHARES.  If the value of an account falls below
$100,000 because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $100,000 for a continuous
60-day period, the shares in such account will be subject to redemption by the
Fund. The Fund will not redeem shares based solely upon changes in the market
that reduce the net asset value of shares. If redeemed, redemption proceeds will
be promptly paid to the shareholder.
 
                              REDEMPTION OF SHARES
 
    Class A and Class B shares of each Portfolio may be redeemed at any time and
without charge at the net asset value per share next determined after receipt by
the Fund of a redemption order as described under "Methods of Redemption."
Redemption proceeds may be more or less than the purchase price of your shares
depending on, among other factors, the market value of the investment securities
held by a Portfolio.
 
METHODS OF REDEMPTION
 
    Shares may be redeemed directly from the Fund by mail or by telephone.
However, shares purchased through a Financial Intermediary must be redeemed
through a Financial Intermediary. Certain Financial Intermediaries may charge an
additional service or transaction fee.
 
    BY MAIL.  Each Portfolio will redeem shares upon receipt of a redemption
request in "good order." Redemption requests may be sent by regular mail to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798 or, by overnight courier, to Morgan Stanley Institutional Fund, Inc.,
c/o Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913.
 
    "Good order" means that the request to redeem shares must include the
following:
 
    1. A letter of instruction or a stock assignment specifying the class and
       number of shares or dollar amount to be redeemed, signed by all
       registered owners of the shares in the exact names in which they are
       registered;
 
    2. Any required signature guarantees; and
 
    3. Other supporting legal documents, if required, in the case of estates,
       trusts, guardianships, custodianships, corporations, pension and
       profit-sharing plans and other organizations.
 
    Redemption requests received in "good order" prior to the Pricing Time will
be executed at the net asset value computed on the date of receipt. Redemption
requests received after the Pricing Time will be executed at the next determined
net asset value. Shareholders who are uncertain of requirements for redemption
by mail should consult with a Fund representative.
 
    BY TELEPHONE.  If you have previously elected the Telephone Redemption
Option on the Account Registration Form, you can redeem Portfolio shares by
calling the Fund and requesting that the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. To change the commercial bank or account designated to receive
redemption proceeds, send a written request to the Fund at the address above.
Requests to change the bank or account must be signed by each shareholder and
each signature must be guaranteed. The telephone redemption option may be
difficult to implement at times, particularly during volatile market conditions.
If you experience difficulty in making a telephone redemption, you may redeem
shares by mail as described above.
 
                                       29
<PAGE>
    The Fund and the Transfer Agent will employ reasonable procedures to confirm
that instructions communicated by telephone are genuine. An investor may be
required to provide personal identification information at the time an account
is opened and prior to effecting each telephone transaction. In addition, all
telephone transaction requests will be recorded and investors may be required to
provide additional telecopied written instructions regarding transaction
requests. Neither the Fund nor the Transfer Agent will be responsible for any
loss, liability, cost or expense for following instructions received by
telephone that either of them reasonably believes to be genuine.
 
    REDEMPTION THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to accept redemption
requests from underlying beneficial owners. These redemptions may be processed
in the same way as purchases made through such Financial Intermediaries, as
described above.
 
FURTHER REDEMPTION INFORMATION
 
    The Fund normally makes payment for all shares redeemed within one business
day of receipt of the request, and in no event more than seven days after
receipt of a redemption request in good order. However, payments to investors
redeeming shares which were purchased by check will not be made until payment
for the purchase has been collected, which may take up to eight days after the
date of purchase. The Fund may suspend the right of redemption or postpone the
date upon which redemptions are effected at times when the NYSE is closed, or
under any emergency conditions as determined by the Securities and Exchange
Commission (the "Commission").
 
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of a Portfolio to make payment in
cash, the Fund may pay redemption proceeds in whole or in part by a
distribution-in-kind of readily marketable portfolio securities in accordance
with applicable rules of the Commission. Shareholders may incur brokerage
charges on the sale of portfolio securities received in payment of redemptions.
 
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required to verify the identity of the person who has authorized
certain redemptions. Please contact the Fund or see the Statement of Additional
Information for further information.
 
                         ACCOUNT POLICIES AND SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares of each Portfolio that you own for shares of any
other available portfolio(s) of the Fund, subject to certain limitations. You
cannot exchange for shares of the International Equity, Emerging Markets, Small
Cap Value Equity, Balanced or Gold Portfolios because they are currently closed
to new investors. In addition, certain portfolios may be unavailable to
shareholders who purchased portfolio shares through a Financial Intermediary.
Contact your Financial Intermediary to determine which portfolios are available
for exchange.
 
    Before you make an exchange, you should read the prospectus of the
portfolio(s) in which you seek to invest. The class of shares you receive in the
exchange will be determined in the same manner as any other purchase of shares,
including minimum initial investment and account size requirements, and will not
be based on the class of shares you surrender for the exchange. Exchange
transactions are treated as a redemption
 
                                       30
<PAGE>
followed by a purchase. Therefore, an exchange will be considered a taxable
event for shareholders subject to tax. Exchange transactions will be processed
at the net asset value per share next determined after receipt of the request.
Shares of the portfolios may be exchanged by mail or telephone. The telephone
exchange privilege is automatic and made available without shareholder election.
The exchange privilege may be modified or terminated by the Fund at any time
upon 60-days notice to shareholders.
 
    BY MAIL.  To exchange shares by mail, send a written exchange request to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798. Your written exchange request should include (i) the name, class of
shares and account number of your current Portfolio; (ii) the name(s) and
class(es) of shares of the portfolio(s) into which you intend to exchange
shares; and (iii) the signatures of all registered account holders.
 
    BY TELEPHONE.  To exchange shares by telephone, call the Fund at the phone
number provided on the cover of this Prospectus. A Fund representative will
request (i) the name, class of shares and account number of your current
Portfolio, and (ii) the name(s) and class(es) of shares of the portfolio(s) into
which you intend to exchange shares. For additional information regarding
responsibility for the authenticity of telephoned instructions, see "Redemption
of Shares" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by sending a written request to Morgan Stanley Institutional Fund, Inc.,
P.O. Box 2798, Boston, Massachusetts 02208-2798. It may not be possible to
transfer the registration of certain shares purchased through a Financial
Intermediary. As with redemptions, the written request must be received in "good
order" before any transfer can be made. Transferring the registration of shares
may affect the eligibility of your account for a given class of shares and may
result in involuntary conversion or redemption of your shares.
 
OTHER ACCOUNT INFORMATION
 
    The Fund does not issue share certificates for the Portfolios. All shares
purchased are confirmed to you and credited to your account on the Fund's books
maintained by the Adviser or its agents. You will have the same rights and
ownership with respect to such shares as if certificates had been issued.
 
EXCESSIVE TRADING
 
    Frequent trades in your account(s) can disrupt management of a Portfolio and
raise its expenses. Consequently, the Fund may, in its discretion and in the
interest of each Portfolio's shareholders and performance, bar a shareholder who
trades excessively from making further share purchases for an indefinite period.
The Fund considers excessive trading to be more than one purchase and sale
involving shares of the same class of a portfolio of the Fund within any 120-day
period. For example, the following series of transactions would amount to
excessive trading: exchanging shares of Portfolio A for shares of Portfolio B,
then exchanging shares of Portfolio B for shares of Portfolio C and then
exchanging shares of Portfolio C for shares of Portfolio A within a 120-day
period. Two types of transactions are exempt from these excessive trading
restrictions: (i) trades exclusively between money market portfolios, and (ii)
trades made in connection with an asset allocation service managed or advised by
the Adviser and/or any of its affiliates.
 
                                       31
<PAGE>
INVESTMENT IN PORTFOLIOS BY OTHER INVESTMENT ACCOUNTS
 
    Morgan Stanley or its affiliates, including Morgan Stanley Asset Management
Inc., manage investment accounts for other clients, including other investment
companies, that invest in Class A or Class B shares of the portfolios. From time
to time, one or more of the Portfolios used for investment by these accounts may
experience relatively large investments or redemptions due to investment
decisions made on behalf of these accounts. These transactions will affect the
portfolios, since portfolios that experience significant redemptions may have to
sell portfolio securities and portfolios that receive additional cash will have
to invest it in additional portfolio securities. It is impossible to predict the
overall impact of these transactions over time, however, there could be adverse
effects on portfolio management. These transactions also could have tax
consequences if sales of portfolio securities result in gains or could increase
transaction costs. The Adviser, representing the interests of the portfolios, is
committed to minimizing the impact of these transactions to the portfolios. The
Adviser, however, will have a conflict in fulfilling this responsibility in that
it also advises these investment accounts. The Adviser will monitor the impact
of these transactions on the Portfolios.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of each of the Portfolios
is determined by dividing the total market value of the Portfolio's investments
and other assets attributable to such class, less any liabilities attributable
to such class, by the total number of outstanding shares of such class of the
Portfolio. Net asset value is calculated separately for each class of a
Portfolio. Net asset value per share is determined as of the close of the NYSE
(normally 4:00 p.m. Eastern Time) on each day that the NYSE is open for
business. Price information on listed securities is taken from the exchange
where the security is primarily traded. Securities listed on a U.S. securities
exchange for which market quotations are available are valued at the last quoted
sale price on the day the valuation is made. Securities listed on a foreign
exchange are valued at their closing price. Unlisted securities and listed
securities not traded on the valuation date and for which market quotations are
not readily available are valued at a price within a range not exceeding the
current asked price nor less than the current bid price. The current bid and
asked prices are determined based on the average of the bid and asked prices
quoted on such valuation date by reputable brokers.
 
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily. In addition, bonds and other fixed income securities may be
valued on the basis of prices provided by a pricing service when such prices are
believed to reflect the fair market value of such securities. The prices
provided by a pricing service are determined without regard to bid or last sale
prices, but take into account institutional-size trading in similar groups of
securities and any developments related to the specific securities. Securities
not priced in this manner are valued at the most recently quoted bid price or,
when securities exchange valuations are used, at the latest quoted sale price on
the day of valuation. If there is no such reported sale, the latest quoted bid
price will be used. Securities purchased with remaining maturities of 60 days or
less are valued at amortized cost, if it approximates market value. In the event
that amortized cost does not approximate market value, market prices as
determined above will be used.
 
    The value of other assets and securities for which quotations are not
readily available (including restricted and unlisted foreign securities) and
those securities for which it is inappropriate to determine prices in
 
                                       32
<PAGE>
accordance with the above-stated procedures are determined in good faith at fair
value using methods determined by the Board of Directors. For purposes of
calculating net asset value per share, all assets and liabilities initially
expressed in foreign currencies will be translated into U.S. dollars at the mean
of the bid and asked price of such currencies against the U.S. dollar as quoted
by a major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distribution expense accrual differential among the classes. The
net asset value of Class B shares will generally be lower than the net asset
value of the Class A shares as a result of the distribution expense charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise total return for each class of the
Portfolios. THESE FIGURES ARE BASED ON HISTORICAL EARNINGS AND ARE NOT INTENDED
TO INDICATE FUTURE PERFORMANCE.
 
    Each of the Portfolios may advertise "total return" which shows what an
investment in a class of a Portfolio would have earned over a specified period
of time (such as one, five or ten years), assuming that all distributions and
dividends by the Portfolio were reinvested in the same class on the reinvestment
dates during the period. Total return does not take into account any federal or
state income taxes that may be payable on dividends and distributions or on
redemption. The Fund may also include comparative performance information in
advertising or marketing the Portfolios' shares, including data from Lipper
Analytical Services, Inc., other industry publications, business periodicals,
rating services and market indices.
 
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains distributions for a class of shares
will be automatically reinvested in additional shares at net asset value, except
when, upon written notice to the Fund or by checking off the appropriate box in
the Distribution Option Section on the Account Registration Form, a shareholder
elects to receive income dividends and capital gains distributions in cash.
 
    The Emerging Growth Portfolio expects to distribute substantially all of its
taxable net investment income in the form of annual dividends and the Equity
Growth and the Aggressive Equity Portfolios expect to distribute substantially
all of their net investment income in the form of quarterly dividends. Net
realized gains for each Portfolio, if any, after reduction for any available tax
loss carryforwards will also be distributed annually.
 
    Undistributed net investment income is included in each Portfolio's net
assets for the purpose of calculating net asset value per share. Therefore, on
the "ex-dividend" date, the net asset value per share excludes the dividend
(i.e., is reduced by the per share amount of the dividend). Dividends paid
shortly after the purchase of shares by an investor, although in effect a return
of capital, are taxable to shareholders subject to income tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
 
                                       33
<PAGE>
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of the Portfolios will differ at times.
Expenses of the Portfolios allocated to a particular class of shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of a Portfolio or its shareholders.
Accordingly, shareholders are urged to consult their tax advisors regarding
specific questions as to federal, state and local income taxes.
 
    Each Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other portfolios. Each Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Code, so that the Portfolio will be relieved
of federal income tax on that part of its net investment income and net capital
gain that is distributed to shareholders.
 
    Each Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, net short-term capital gain) to
shareholders. Dividends from a Portfolio's net investment income are taxable to
shareholders as ordinary income, whether received in cash or in additional
shares. Such dividends paid by a Portfolio will generally qualify for the
dividends-received deduction for corporate shareholders only to the extent of
the aggregate qualifying dividend income received by the Portfolio from U.S.
corporations. Each Portfolio will report annually to its shareholders the amount
of dividend income qualifying for such treatment.
 
    Distributions of net capital gain are taxable to shareholders as a 20% rate
gain distribution (taxed at a rate of 20%) or a 28% rate gain distribution
(taxed at a rate of 28%), depending upon the designation by the Portfolio (such
designation being dependent upon the holding period of the Portfolio in the
underlying asset generating the net capital gain), regardless of how long
shareholders have held their shares. Each Portfolio will send reports annually
to its shareholders of the federal income tax status of all distributions made
during the preceding year.
 
    Each Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gain over short-term and long-term capital
loss, including any available capital loss carryforwards), prior to the end of
each calendar year to avoid liability for federal excise tax.
 
    Dividends and other distributions declared by a Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders in that year if the distributions are paid by the Portfolio at
any time during the following January.
 
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any dividends, capital gains distributions and redemption proceeds paid to any
individual or certain other non-corporate shareholder (i) who has failed to
provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Account Registration Form; (ii) who is subject to
 
                                       34
<PAGE>
backup withholding by the Internal Revenue Service; or (iii) who has not
certified to the Fund that such shareholder is not subject to backup
withholding. This backup withholding is not an additional tax, and any amounts
withheld may be credited against the shareholder's ultimate U.S. tax liability.
 
    The sale, exchange or redemption of shares will result in taxable gain or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the sale, exchange or redemption proceeds exceeds or is
less than the shareholder's adjusted tax basis in the sold, exchanged or
redeemed shares. If capital gains distributions have been made with respect to
shares that are sold at a loss after being held for six months or less, however,
then the loss is treated as a long-term capital loss to the extent of the
capital gains distributions.
 
    Conversions of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisors concerning the
application of state and local income taxes to investments in a Portfolio, which
may differ from the federal income tax consequences described above.
 
    Investment income received by a Portfolio from sources within foreign
countries may be subject to foreign income taxes withheld at the source. To the
extent that a Portfolio is liable for foreign income taxes so withheld, it is
not expected that a Portfolio or its shareholders would be able to claim a
credit for U.S. tax purposes with respect to any such foreign taxes.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN A PORTFOLIO.
 
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolio
for their clients.
 
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other remuneration paid to Morgan Stanley or other affiliates must be
fair and reasonable in comparison to those of other broker-dealers for
comparable transactions involving similar securities being purchased or sold
during a comparable time period.
 
                                       35
<PAGE>
PORTFOLIO TURNOVER
 
    The Portfolios generally do not invest for short-term trading purposes,
however, when circumstances warrant, each Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolios will not consider portfolio turnover rate
a limiting factor in making investment decisions consistent with their
respective objectives and policies. For the fiscal year ended December 31, 1997,
the Equity Growth, Emerging Growth and Aggressive Equity Portfolios had
portfolio turnover rates of 177%, 228% and 302%, respectively. Higher portfolio
turnover (e.g., over 100%) necessarily will cause the Portfolios to pay
correspondingly increased brokerage and trading costs. In addition to
transaction costs, higher portfolio turnover may result in the realization of
capital gains. As discussed under "Taxes," to the extent net short-term capital
gains are realized, any distributions resulting from such gains are considered
ordinary income for federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 40 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of each
Portfolio are currently classified into two classes, the Class A shares and the
Class B shares.
 
    The shares of the Portfolios, when issued, will be fully paid,
nonassessable, fully transferable and redeemable at the option of the holder.
The shares have no preference as to conversion, exchange, dividends, retirement
or other features and have no pre-emptive rights. The shares of each Portfolio
have non-cumulative voting rights, which means that the holders of more than 50%
of the shares voting for the election of Directors can elect 100% of the
Directors if they choose to do so. Persons or organizations owning 25% or more
of the outstanding shares of a Portfolio may be presumed to "control" (as
defined in the 1940 Act) such Portfolio. Under Maryland law, the Fund is not
required to hold an annual meeting of its shareholders unless required to do so
under the 1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual and semi-annual reports. The
financial statements appearing in annual reports are audited by independent
accountants. Monthly unaudited portfolio data is also available from the Fund
upon request.
 
    In addition, the Adviser or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
                                       36
<PAGE>
CUSTODIAN
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs subcustodians approved by the Board of Directors of the Fund
in accordance with regulations of the Commission for the purpose of providing
custodial services for such assets. MSTC may also hold certain domestic assets
for the Fund. For more information on the custodians, see "General Information
- -- Custody Arrangements" in the Statement of Additional Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits the annual financial statements of each Portfolio.
 
FUND COUNSEL
 
    Morgan, Lewis & Bockius LLP acts as the Fund's legal counsel.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       37
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
          EQUITY GROWTH, EMERGING GROWTH
           AND AGGRESSIVE EQUITY PORTFOLIOS
           P.O. BOX 2798, BOSTON, MA 02208-2798
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                                           <C>
                                                                    If you need assistance in filling out this form for the
      ACCOUNT INFORMATION                                           Morgan Stanley Institutional Fund, Inc., please contact your
      Fill in where applicable                                      Morgan Stanley representative or call us toll free
                                                                    1-800-548-7786. Please print all items except signature, and
                                                                    mail to the Fund at the address above.
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
        (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
        TENANCY IN COMMON
        IS INDICATED)
</TABLE>
 
1.
                               First
Name                          Initial                               Last Name
2.
                               First
Name                          Initial                               Last Name
                               First
Name                          Initial                               Last Name
 
<TABLE>
<C>   <S>                                       <C>
      3. CORPORATIONS,
        TRUSTS AND OTHERS
        Please call the Fund for additional
      documents that may be required to set up
      account and to authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                    <C>               <C>                        <C>               <C>
Type of Registration:  / / INCORPORATED  / / UNINCORPORATED         / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                         ASSOCIATION                                    (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
 
<TABLE>
<C>   <S>                                       <C>
  B)  MAILING ADDRESS
      Please fill in completely, including
      telephone number(s).
</TABLE>
 
<TABLE>
<C>   <S>                                       <C>                             <C>
/ / United States Citizen  / / Resident Alien
 
                   Street or P.O. Box
 
                                                                                OR
                                                1.          TAXPAYER            SOCIAL SECURITY NUMBER
                                                IDENTIFICATION NUMBER           ("SSN")
                                                ("TIN")                         ------------- -------------
                                                ------------ ------------       ------------- - - - - - - - -
                                                ------------ - - - - - - - -    -
                                                -
                                                --
 
                   City
                   State                   Zip
 
Home Telephone No.                   Business Telephone No.
 
/ / Non-Resident Alien
 
Permanent Address (Where you reside permanently for tax purposes)
      of a minor (Uniform                       --        --                    OR                             SSN
                                                2.    TIN        - - - - - - -  ------------- -------------
                                                -- - - -                        ------------- - - - - - - - -
                                                --                              -
 
                   Street Address
 
                   City
                   Country                   Postal Code
                                                --        --      TIN        -                                 SSN
                                                -- - - - - - - - - -            ------------- -------------
                                                                                ------------- - - - - - - - -
                                                                                -
 
Home Telephone No.                    Business Telephone No.
                                                IMPORTANT TAX INFORMATION
                                                You (as a payee) are required by law to provide us (as payer)
                                                with your correct TIN(s) or SSN(s). Accounts that have a
                                                missing or incorrect
                                                --
 
Current Mailing Address (If different from Permanent Address)
 
                   Street Address
 
                   City
                   Country
 
Postal Code
Home Telephone No.                   Business Telephone No.
                                                --        --
                                                TIN(s) or SSN(s) will be subject to backup withholding at a
                                                31% rate on dividends, distributions and other payments. If
                                                you have not provided us with your correct TIN(s) or SSN(s),
                                                you may be subject to a $50 penalty imposed by the Internal
                                                Revenue Service.
                                                Backup withholding is not an additional tax; the tax liability
                                                of persons subject to backup withholding will be reduced by
                                                the amount of tax withheld. If withholding results in an
                                                overpayment of taxes, a refund may be obtained.
                                                You may be notified that you are subject to backup withholding
                                                under Section 3406(a)(1)(C) of the Internal Revenue Code
  C)  TAXPAYER                                  because you have underreported interest or dividends or you
      IDENTIFICATION
      NUMBER
      1. INDIVIDUAL
      2. JOINT TENANTS
        (RIGHTS OF SURVIVORSHIP PRESUMED        were required to, but failed to, file a return which would
      UNLESS                                    have included a reportable interest or dividend payment.
        TENANCY IN COMMON                       Enter your Taxpayer Identification Number. For most individual
        IS INDICATED)                           taxpayers, this is your Social Security Number.
      For Custodian account
      Gifts/Transfers to Minor                                                  OR
      Acts), give the Social
      Security Number of
      the minor.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                       <C>                             <C>                   <C>
  D)  PORTFOLIO AND                             For Purchase of the following   / / Class A Shares $  / / Class B Shares $
      CLASS SECTION                             Portfolio(s):                   / / Class A Shares $  / / Class B Shares $
      (Class A shares minimum $500,000 for      Equity Growth Portfolio         / / Class A Shares $  / / Class B Shares $
      each Portfolio and Class B shares         Emerging Growth Portfolio
      minimum $100,000 for each Portfolio).     Aggressive Equity Portfolio
      Please indicate Portfolio, class and
      amount.
                                                                                Total Initial Investment $
</TABLE>
 
<TABLE>
<C>   <S>                                       <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate portfolio and manner of
      payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                                 <C>
/ / Exchange $ From                                                                           -- - - - - - - - - - -- - -
                                                                Name of Portfolio                     Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on                       -- - - - - - - - - - -- - -
                                                                                            Account No.               (Check
                                                                                      (Previously assigned by the Fund)     Digit)
                                                                            Date
</TABLE>
 
<TABLE>
<C>   <S>                                       <C>
  F)  DISTRIBUTION                              Income dividends and capital gains distributions (if any) to
      OPTION                                    be reinvested in additional shares unless either box below
                                                is checked.
                                                / / Income dividends to be paid in cash, capital gains
                                                distributions (if any) in shares.
                                                / / Income dividends and capital gains distributions (if
                                                any) to be paid in cash.
</TABLE>
<TABLE>
<C>   <S>                             <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone
      AND EXCHANGE                    requests to wire redemption proceeds to
      OPTION                          the commercial bank indicated at right
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund
      wish to redeem or exchange      account is registered if such requests
      shares by telephone. A          are believed to be authentic.
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated
      YOUR FUND ACCOUNT.              by telephone are genuine. These
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal
      NOT BE HONORED UNLESS THE BOX   identification information at the time
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
 
<CAPTION>
  G)
      Name of COMMERCIAL Bank (Not Savings Bank)
      Bank Account No.
                                                   Bank ABA No.
      Name(s) in which your Bank Account is Established
      Bank's Street Address
      City                           State                           Zip
</TABLE>
 
<TABLE>
<C>   <S>                                       <C>
  H)  INTERESTED PARTY                          Name
      OPTION                                    Address
      In addition to the account statement      City         State         Zip Code
      sent to my/our registered address, I/we
      hereby authorize the Fund to mail
      duplicate statements to the name and
      address provided at right.
</TABLE>
 
<TABLE>
<C>   <S>                                       <C>
  I)  DEALER
      INFORMATION
                                                Representative Name                        Representative
                                                No.                            Branch
                                                No.
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here ,
</TABLE>
 
<TABLE>
<S>                                  <C>
The undersigned certify that I/we have full authority and legal capacity
to purchase and redeem shares of the Fund and affirm that I/we have
received a current Prospectus of the Morgan Stanley Institutional Fund,
Inc. and agree to be bound by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF
PERJURY THAT THE INFORMATION ON THIS APPLICATION IS COMPLETE AND CORRECT
AND THAT AS REQUIRED BY FEDERAL LAW (PLEASE CHECK APPLICABLE BOXES
BELOW):
/ / U.S. CITIZEN(S)/TAXPAYER(S):
       / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM
           IS/ARE THE CORRECT SSN(S) OR TIN(S) AND (2) I/WE ARE NOT
           SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE ARE
           EXEMPT FROM BACKUP WITHHOLDING; (B) I/WE HAVE NOT BEEN
           NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT I/WE
           ARE SUBJECT TO BACKUP WITHHOLDING AS A RESULT OF A FAILURE TO
           REPORT ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED
           ME/US THAT I AM/WE ARE NO LONGER SUBJECT TO BACKUP
           WITHHOLDING.
       / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE
           HAVE APPLIED, OR INTEND TO APPLY, TO THE IRS OR THE SOCIAL
           SECURITY ADMINISTRATION FOR A TIN OR A SSN AND I/WE
           UNDERSTAND THAT IF I/WE DO NOT PROVIDE EITHER NUMBER TO CHASE
           GLOBAL FUNDS SERVICES COMPANY ("CGFSC") WITHIN 60 DAYS OF THE
           DATE OF THIS APPLICATION OR IF I/WE FAIL TO FURNISH MY/OUR
           CORRECT SSN(S) OR TIN(S), I/WE MAY BE SUBJECT TO A PENALTY
           AND A 31% BACKUP WITHHOLDING ON DISTRIBUTIONS AND REDEMPTION
           PROCEEDS. (PLEASE PROVIDE EITHER NUMBER ON IRS FORM W-9). YOU
           MAY REQUEST SUCH FORM BY CALLING CGFSC AT 800-282-4404.
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
  UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S.
CITIZENS OR RESIDENTS AND I/WE ARE EXEMPT FOREIGN PERSONS AS DEFINED BY
THE INTERNAL REVENUE SERVICE.
 
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY
PROVISION OF THIS DOCUMENT OTHER THAN THE CERTIFICATIONS REQUIRED TO
AVOID BACKUP WITHHOLDING.
 
                                     (X)
(X)                                  Signature (if joint account, both
Signature                                            Date must sign)              Date
</TABLE>
<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<S>                                                 <C>
                                                    PAGE
                                                    ----
Fund Expenses.....................................    2
Financial Highlights..............................    4
Prospectus Summary................................    8
Investment Objectives and Policies................   12
Additional Investment Information.................   14
Investment Limitations............................   23
Management of the Fund............................   24
Purchase of Shares................................   26
Redemption of Shares..............................   29
Account Policies and Services.....................   30
Valuation of Shares...............................   32
Performance Information...........................   33
Dividends and Capital Gains Distributions.........   33
Taxes.............................................   34
Portfolio Transactions............................   35
General Information...............................   36
Account Registration Form
</TABLE>
 
                            EQUITY GROWTH PORTFOLIO
                           EMERGING GROWTH PORTFOLIO
                          AGGRESSIVE EQUITY PORTFOLIO
                               PORTFOLIOS OF THE
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
 
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  Incorporated
 
                                 Morgan Stanley
                            Institutional Fund, Inc.
                      P.O. Box 2798, Boston, MA 02208-2798
 
- ---------------------------------
- ---------------------------------
- ---------------------------------
- ---------------------------------
<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
     ----------------------------------------------------------------------
 
                         EUROPEAN REAL ESTATE PORTFOLIO
                          ASIAN REAL ESTATE PORTFOLIO
                           U.S. REAL ESTATE PORTFOLIO
 
                               PORTFOLIOS OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
 
                                ----------------
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a series of diversified and non-diversified investment portfolios
("portfolios"). The Fund is designed to provide clients with attractive
alternatives for meeting their investment needs. The Fund currently consists of
thirty-two portfolios representing a broad range of investment choices. This
prospectus (the "Prospectus") pertains to the Class A and the Class B shares of
the European Real Estate, Asian Real Estate and U.S. Real Estate Portfolios
(each a "Portfolio" and together, the "Portfolios"). The Class A and Class B
shares currently offered by the Portfolios have different minimum investment
requirements and fund expenses. Shares of the Portfolios are offered with no
sales charge, exchange fee or redemption fee.
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator"), and with Morgan Stanley & Co. Incorporated ("Morgan Stanley")
as Distributor, the Fund makes available to institutional and high net worth
individual investors a series of portfolios which benefit from the investment
expertise and commitment to excellence associated with Morgan Stanley and its
affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under "Prospectus Summary" below. The Fund
currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging Markets,
European Equity, European Real Estate, Global Equity, International Equity,
International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) EQUITY AND FIXED INCOME -- Balanced
Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global
Fixed Income, High Yield and Municipal Bond Portfolios; and (v) MONEY MARKET --
Money Market and Municipal Money Market Portfolios. Additional information about
the Fund is contained in a "Statement of Additional Information" dated May 1,
1998, which is incorporated herein by reference. The Statement of Additional
Information and the prospectuses pertaining to the other portfolios of the Fund
are available upon request and without charge by writing or calling the Fund at
the address and telephone number set forth above.
 
THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
  EXCHANGE COMMISSION, NOR HAS THE SECURITIES AND EXCHANGE COMMISSION
     PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY
               REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
                  THE DATE OF THIS PROSPECTUS IS MAY 1, 1998.
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates the expenses and fees that a shareholder of
each Portfolio will incur:
 
<TABLE>
<CAPTION>
                                                              EUROPEAN      ASIAN       U.S.
                                                                REAL        REAL        REAL
                                                               ESTATE      ESTATE      ESTATE
SHAREHOLDER TRANSACTION EXPENSES                              PORTFOLIO   PORTFOLIO   PORTFOLIO
- ------------------------------------------------------------  ---------   ---------   ---------
<S>                                                           <C>         <C>         <C>
Maximum Sales Load Imposed on Purchases
  Class A...................................................       None        None        None
  Class B...................................................       None        None        None
Maximum Sales Load Imposed on Reinvested Dividends
  Class A...................................................       None        None        None
  Class B...................................................       None        None        None
Deferred Sales Load
  Class A...................................................       None        None        None
  Class B...................................................       None        None        None
Redemption Fees
  Class A...................................................       None        None        None
  Class B...................................................       None        None        None
Exchange Fees
  Class A...................................................       None        None        None
  Class B...................................................       None        None        None
</TABLE>
 
<TABLE>
<CAPTION>
ANNUAL FUND OPERATING EXPENSES
 (AS A PERCENTAGE OF AVERAGE NET ASSETS)
- ------------------------------------------------------------
Management Fee (Net of Fee Waivers)*
<S>                                                           <C>         <C>         <C>
  Class A...................................................      0.00%       0.00%       0.76%
  Class B...................................................      0.00%       0.00%       0.76%
12b-1 Fees
  Class A...................................................       None        None        None
  Class B...................................................      0.25%       0.25%       0.25%
Other Expenses
  Class A...................................................      1.00%       1.00%       0.24%
  Class B...................................................      1.00%       1.00%       0.24%
                                                                   ---         ---         ---
Total Operating Expenses (Net of Fee Waivers)*
  Class A...................................................      1.00%       1.00%       1.00%
  Class B...................................................      1.25%       1.25%       1.25%
                                                                   ---         ---         ---
                                                                   ---         ---         ---
</TABLE>
 
- ------------------------
*The Adviser has agreed to waive its management fees and/or reimburse the
 Portfolios, if necessary, if such fees would cause the total annual operating
 expenses of each of the Portfolios to exceed a specified percentage of its
 respective average daily net assets. As a result of these reductions, the
 Management Fees stated above are lower than the contractual fees stated under
 "Management of the Fund." The Adviser reserves the right to terminate any of
 its fee waivers and/or expense reimbursements at any time in its sole
 discretion. For further information on Fund expenses, see "Management of the
 Fund." Set forth below, for each Portfolio, are the management fees and total
 operating expenses absent such fee waivers and/or expense reimbursements as a
 percentage of the average daily net assets of the Class A shares and Class B
 shares, respectively.
 
                                       2
<PAGE>
 
<TABLE>
<CAPTION>
                                                             TOTAL OPERATING
                                          MANAGEMENT            EXPENSES
                                              FEE          ABSENT FEE WAIVERS
                                          ABSENT FEE    -------------------------
PORTFOLIO                                   WAIVERS       CLASS A       CLASS B
- ----------------------------------------  -----------   -----------   -----------
<S>                                       <C>           <C>           <C>
European Real Estate Portfolio..........     0.80%            3.05%         3.12%
Asian Real Estate Portfolio.............     0.80%           12.95%        13.20%
U.S. Real Estate Portfolio..............     0.80%            1.04%         1.28%
</TABLE>
 
    The purpose of the table above is to assist the investor in understanding
the various expenses that an investor in the Portfolios will bear directly or
indirectly. Expenses and fees for the U.S. Real Estate Portfolio are based on
actual figures for the period ended December 31, 1997. Expenses and fees for the
European Real Estate and Asian Real Estate Portfolios are based on estimates
assuming that the average daily net assets of both the Class A and Class B
shares of the Portfolios will be $50,000,000. Due to the continuous nature of
Rule 12b-1 fees, long term Class B shareholders may pay more than the equivalent
of the maximum front-end sales charges otherwise permitted by the National
Association of Securities Dealers, Inc. ("NASD") Conduct Rules.
 
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (i) a 5% annual rate of return, and (ii) redemption
at the end of each time period. As noted in the table above, the Portfolios
charge no redemption fees of any kind. The example is based on total operating
expenses of the Portfolios after fee waivers.
 
<TABLE>
<CAPTION>
                                                                       1 YEAR       3 YEARS      5 YEARS     10 YEARS
                                                                     -----------  -----------  -----------  -----------
<S>                                                                  <C>          <C>          <C>          <C>
European Real Estate Portfolio
  Class A..........................................................   $      10    $      32        *            *
  Class B..........................................................          13           40        *            *
Asian Real Estate Portfolio
  Class A..........................................................          10           32        *            *
  Class B..........................................................          13           40        *            *
U.S. Real Estate Portfolio
  Class A..........................................................          10           32           55          122
  Class B..........................................................          13           40           69          151
</TABLE>
 
- ------------------------
*Because the European Real Estate and Asian Real Estate Portfolios are new, the
 Fund has not projected expenses for these Portfolios beyond the three year
 period shown.
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. ACTUAL EXPENSES MAY BE GREATER OR LESS THAN THOSE
SHOWN.
 
                                       3
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following table provides financial highlights for the Class A and Class
B shares of each of the Portfolios for each of the periods presented. The
audited financial highlights for each Portfolio's shares for each of the periods
presented are part of the Fund's financial statements which appear in the Fund's
December 31, 1997 Annual Report to Shareholders and which are incorporated by
reference into the Fund's Statement of Additional Information. Each Portfolio's
financial highlights for each of the periods presented have been audited by
Price Waterhouse LLP, whose unqualified report thereon is also incorporated by
reference into the Statement of Additional Information. Additional performance
information is included in the Annual Report. The Annual Report and the
financial statements therein, along with the Statement of Additional
Information, are available at no cost from the Fund at the address and telephone
number noted on the cover page of this Prospectus. The following information
should be read in conjunction with the financial statements and notes thereto.
 
                                       4
<PAGE>
                           U.S. REAL ESTATE PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                       CLASS A                            CLASS B
                                                         ------------------------------------   ---------------------------
                                                                                 PERIOD FROM                   PERIOD FROM
                                                          YEAR ENDED DECEMBER    FEBRUARY 24,                   JANUARY 2,
                                                                  31,              1995* TO      YEAR ENDED     1996*** TO
                                                         ---------------------   DECEMBER 31,   DECEMBER 31,   DECEMBER 31,
                                                           1997        1996          1995           1997           1996
                                                         ---------   ---------   ------------   ------------   ------------
<S>                                                      <C>         <C>         <C>            <C>            <C>
NET ASSET VALUE, BEGINNING OF PERIOD...................  $   14.41   $   11.42     $ 10.00        $ 14.39        $ 11.50
                                                         ---------   ---------   ------------   ------------   ------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)............................       0.42        0.37        0.26           0.47           0.35
  Net Realized and Unrealized Gain on Investments......       3.40        4.02        1.84           3.29           3.92
                                                         ---------   ---------   ------------   ------------   ------------
    Total from Investment Operations...................       3.82        4.39        2.10           3.76           4.27
                                                         ---------   ---------   ------------   ------------   ------------
DISTRIBUTIONS
  Net Investment Income................................      (0.43)      (0.39)      (0.24)         (0.39)         (0.37)
  Net Realized Gain....................................      (2.16)      (1.01)      (0.44)         (2.16)         (1.01)
  In Excess of Net Realized Gain.......................      (0.26)     --          --              (0.26)        --
                                                         ---------   ---------   ------------   ------------   ------------
    Total Distributions................................      (2.85)      (1.40)      (0.68)         (2.81)         (1.38)
                                                         ---------   ---------   ------------   ------------   ------------
NET ASSET VALUE, END OF PERIOD.........................  $   15.38   $   14.41     $ 11.42        $ 15.34        $ 14.39
                                                         ---------   ---------   ------------   ------------   ------------
                                                         ---------   ---------   ------------   ------------   ------------
TOTAL RETURN...........................................      27.62%      39.56%      21.07%         27.21%         38.23%
                                                         ---------   ---------   ------------   ------------   ------------
                                                         ---------   ---------   ------------   ------------   ------------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)................   $361,549    $210,368     $69,509        $21,231         $8,734
  Ratio of Expenses to Average Net Assets (1)..........       1.00%       1.00%       1.00%**        1.25%          1.25%**
  Ratio of Net Investment Income to Average Net
   Assets (1)..........................................       2.72%       3.08%       4.04%**        3.49%          2.91%**
  Portfolio Turnover Rate..............................        135%        171%        158%           135%           171%
  Average Commission Rate Per Share #..................  $  0.0593     $0.0568         N/A        $0.0593        $0.0568
</TABLE>
 
- ------------------------------
 
<TABLE>
<C>  <S>                                                    <C>          <C>            <C>            <C>            <C>
(1)  Effect of voluntary expense limitation during the
      period:
       Per share benefit to net investment income......       $0.01        $0.02         $0.02          $0.00+         $0.02
     Ratios before expense limitation:
       Expenses to Average Net Assets..................        1.04%        1.14%         1.33%**        1.28%          1.37%**
       Net Investment Income to Average Net Assets.....        2.68%        2.93%         3.71%**        3.46%          2.79%**
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996
 
  + Amount is less than $0.01 per share.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period.
 
                                       5
<PAGE>
                         EUROPEAN REAL ESTATE PORTFOLIO
 
<TABLE>
<CAPTION>
                                                 CLASS A        CLASS B
                                               ------------   ------------
                                               PERIOD FROM    PERIOD FROM
                                                OCTOBER 1,     OCTOBER 1,
                                                 1997* TO       1997* TO
                                               DECEMBER 31,   DECEMBER 31,
                                                   1997           1997
                                               ------------   ------------
<S>                                            <C>            <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........    $ 10.00        $ 10.00
                                               ------------   ------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)..................       0.05           0.02
  Net Realized and Unrealized Loss on
   Investments...............................      (0.52)         (0.50)
                                               ------------   ------------
    Total from Investment Operations.........      (0.47)         (0.48)
                                               ------------   ------------
DISTRIBUTIONS
  Net Investment Income......................      (0.01)        --
                                               ------------   ------------
    Total Distributions......................      (0.01)        --
                                               ------------   ------------
NET ASSET VALUE, END OF PERIOD...............    $  9.52        $  9.52
                                               ------------   ------------
                                               ------------   ------------
TOTAL RETURN.................................      (4.72)%        (4.76)%
                                               ------------   ------------
                                               ------------   ------------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)......    $15,177           $789
  Ratio of Expenses to Average Net
   Assets (1)................................       1.00%**        1.25%**
  Ratio of Net Investment Income to Average
   Net Assets (1)............................       2.08%**        1.51%**
  Portfolio Turnover Rate....................         47%            47%
  Average Commission Rate Per Share..........    $0.0155        $0.0155
</TABLE>
 
- ------------------------------
 
<TABLE>
<C>  <S>                                            <C>            <C>
Average Commission Rate as a Percentage of
Trade Amount.................................         0.23%          0.23%
(1)  Effect of voluntary expense limitation
      during the period:
       Per share benefit to net investment
        income...............................        $0.05          $0.03
     Ratios before expense limitation:
       Expenses to Average Net Assets........         3.05%**        3.12%**
       Net Investment Income to Average Net
        Assets...............................         0.03%**       (0.36)%**
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 
 ** Annualized
 
                                       6
<PAGE>
                          ASIAN REAL ESTATE PORTFOLIO
 
<TABLE>
<CAPTION>
                                                 CLASS A        CLASS B
                                               ------------   ------------
                                               PERIOD FROM    PERIOD FROM
                                                OCTOBER 1,     OCTOBER 1,
                                                 1997* TO       1997* TO
                                               DECEMBER 31,   DECEMBER 31,
                                                   1997           1997
                                               ------------   ------------
<S>                                            <C>            <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........    $ 10.00        $ 10.00
                                               ------------   ------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1)..................       0.11         --
  Net Realized and Unrealized Loss on
   Investments...............................      (2.10)         (1.97)
                                               ------------   ------------
    Total from Investment Operations.........      (1.99)         (1.97)
                                               ------------   ------------
DISTRIBUTIONS
  Net Investment Income......................      (0.07)        --
                                               ------------   ------------
    Total Distributions......................      (0.07)        --
                                               ------------   ------------
NET ASSET VALUE, END OF PERIOD...............    $  7.94        $  8.03
                                               ------------   ------------
                                               ------------   ------------
TOTAL RETURN.................................     (19.92)%       (19.70)%
                                               ------------   ------------
                                               ------------   ------------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)......     $2,385             $0+
  Ratio of Expenses to Average Net
   Assets (1)................................       1.08%**        1.18%**
  Ratio of Expenses to Average Net Assets
   Excluding Interest Expense................       1.00%**      N/A
  Ratio of Net Investment Income to Average
   Net Assets (1)............................       5.21%**        4.24%**
  Portfolio Turnover Rate....................         38%            38%
  Average Commission Rate Per Share..........    $0.0061        $0.0061
</TABLE>
 
- ------------------------------
 
<TABLE>
<C>  <S>                                            <C>            <C>
Average Commission Rate as a Percentage of
Trade Amount.................................         0.43%          0.43%
(1)  Effect of voluntary expense limitation
      during the period:
       Per share benefit to net investment
        income...............................        $0.25            N/A
     Ratios before expense limitation:
       Expenses to Average Net Assets........        12.95%**         N/A
       Net Investment Loss to Average Net
        Assets...............................        (6.66)%**        N/A
</TABLE>
 
- --------------------------------------------------------------------------------
 * Commencement of operations
 
** Annualized
 
 + Less than $500.
 
                                       7
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and high net worth individual investors a broad range of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates providing customized services as Adviser, Administrator and
Distributor. Each portfolio offers Class A shares and Class B shares, except for
the International Small Cap and Municipal Money Market Portfolios which offer
only Class A shares. Each portfolio has its own investment objective and
policies designed to meet its specific goals. The investment objective of each
Portfolio described in this Prospectus is as follows:
 
     -     The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income
           and long-term capital appreciation by investing primarily in equity
           securities of companies in the European real estate industry.
     -     The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
           appreciation by investing primarily in equity securities of
           companies in the Asian real estate industry.
     -     The U.S. REAL ESTATE PORTFOLIO seeks to provide above-average
           current income and long-term capital appreciation by investing
           primarily in equity securities of companies in the U.S. real estate
           industry, including substantial investment in real estate investment
           trusts.
 
    The other portfolios of the Fund are described in other prospectuses which
may be obtained from the Fund at the address and phone number noted on the cover
page of this Prospectus. The investment objectives of these other portfolios are
listed below:
 
     GLOBAL AND INTERNATIONAL EQUITY:
     -     The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
           appreciation by investing in accordance with country weightings
           determined by the Adviser in equity securities of non-U.S. issuers
           which, in the aggregate, replicate broad country indices.
     -     The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by
           investing primarily in equity securities of Asian issuers.
     -     The CHINA GROWTH PORTFOLIO seeks to provide long-term capital
           appreciation by investing primarily in equity securities of issuers
           in The People's Republic of China, Hong Kong and Taiwan.
     -     The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation
           by investing primarily in equity securities of emerging country
           issuers.
     -     The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation
           by investing primarily in equity securities of European issuers.
     -     The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
           investing primarily in equity securities of issuers throughout the
           world, including U.S. issuers.
     -     The GOLD PORTFOLIO seeks long-term capital appreciation by investing
           primarily in equity securities of foreign and domestic issuers
           engaged in gold-related activities.
     -     The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital
           appreciation by investing primarily in equity securities of non-U.S.
           issuers.
 
                                       8
<PAGE>
 
<TABLE>
     <S>   <C>
     -     The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital
           appreciation by investing primarily in equity securities of non-U.S.
           issuers domiciled in EAFE countries.
     -     The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital
           appreciation by investing primarily in equity securities of non-U.S.
           issuers with equity market capitalizations of less than $1 billion.
     -     The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation
           by investing primarily in equity securities of Japanese issuers.
     -     The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
           investing primarily in equity securities of Latin American issuers
           and, from time to time, debt securities issued or guaranteed by
           Latin American governments or governmental entities.
 
     U.S. EQUITY:
     -     The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by
           investing primarily in corporate equity and equity-linked
           securities.
     -     The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation
           by investing primarily in growth-oriented equity securities of
           small- to medium-sized corporations.
     -     The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
           investing primarily in growth-oriented equity securities of medium
           and large capitalization companies.
     -     The MICROCAP PORTFOLIO seeks long-term capital appreciation by
           investing primarily in growth-oriented equity securities of small
           corporations.
     -     The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total
           return by investing in equity securities of small- to medium-sized
           companies which the Adviser believes to be undervalued.
     -     The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by
           investing primarily in equity securities of companies that, in the
           opinion of the Adviser, are expected to benefit from their
           involvement in technology and technology-related industries.
     -     The U.S. EQUITY PLUS PORTFOLIO seeks long-term capital appreciation
           by investing primarily in equity securities of issuers included in
           the Standard & Poor's 500 Index ("S&P 500").
     -     The VALUE EQUITY PORTFOLIO seeks high total return by investing in
           equity securities which the Adviser believes to be undervalued
           relative to the stock market in general at the time of purchase.
 
     EQUITY AND FIXED INCOME:
     -     The BALANCED PORTFOLIO seeks high total return while preserving
           capital by investing in a combination of equity securities which the
           Adviser believes to be undervalued and fixed income securities.
 
     FIXED INCOME:
     -     The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by
           investing primarily in debt securities of government,
           government-related and corporate issuers located in emerging
           countries.
     -     The FIXED INCOME PORTFOLIO seeks to produce a high total return
           consistent with the preservation of capital by investing in a
           diversified portfolio of fixed income securities.
     -     The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive
           real rate of return while preserving capital by investing in fixed
           income securities of issuers throughout the world, including U.S.
           issuers.
</TABLE>
 
                                       9
<PAGE>
 
<TABLE>
     <S>   <C>
     -     The HIGH YIELD PORTFOLIO seeks to maximize total return by investing
           in a diversified portfolio of high yield fixed income securities
           that offer a yield above that generally available on debt securities
           in the four highest rating categories of the recognized rating
           services.
     -     The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a
           level of current income as is consistent with the preservation of
           capital by investing primarily in a variety of investment grade
           mortgage-backed securities.
     -     The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of
           current income consistent with preservation of principal by
           investing in municipal obligations, the interest on which is exempt
           from federal income tax.
 
     MONEY MARKET:
     -     The MONEY MARKET PORTFOLIO seeks to maximize current income and
           preserve capital while maintaining high levels of liquidity through
           investing in high quality money market instruments with remaining
           maturities of one year or less.
     -     The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current
           tax-exempt income and preserve capital while maintaining high levels
           of liquidity through investing in high quality money market
           instruments with remaining maturities of one year or less which are
           exempt from federal income tax.
</TABLE>
 
    THE CHINA GROWTH, GOLD, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS
    ARE CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley Dean Witter & Co., acts as investment adviser to the Fund and each of
its portfolios. As of March 31, 1998, Morgan Stanley Asset Management Inc. and
its affiliated institutional asset management companies managed assets of
approximately $166 billion, including assets under fiduciary advice. See
"Management of the Fund -- Investment Adviser" and "Management of the Fund --
Administrator."
 
HOW TO INVEST
 
    Class A shares of each Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of each
Portfolio are offered at net asset value with no sales commission, but with a
12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25% of the
Class B shares' average daily net assets on an annualized basis. Share purchases
may be made by sending investments directly to the Fund or through the
Distributor. The minimum initial investment, generally, is $500,000 for Class A
shares of each Portfolio and $100,000 for the Class B shares of each Portfolio.
The minimum initial investment amount is reduced for certain categories of
investors. For additional information on how to purchase shares and minimum
initial investments, see "Purchase of Shares."
 
HOW TO REDEEM
 
    Class A shares or Class B shares of each Portfolio may be redeemed at any
time, without cost, at the net asset value per share of shares of the applicable
class next determined after receipt of the redemption request. The redemption
price may be more or less than the purchase price. Certain redemptions that
cause the value of an account to remain for a continuous 60-day period below the
minimum investment amount for Class A shares
 
                                       10
<PAGE>
or for Class B shares may result in involuntary redemption or automatic
conversion. For additional information on how to redeem shares and involuntary
redemption or conversion, see "Purchase of Shares" and "Redemption of Shares."
 
RISK FACTORS
 
    Investing in each of the Portfolios entails certain risks and considerations
of which an investor should be aware. The Portfolios' share prices and
investment returns fluctuate and, when redeemed, an investment in the Portfolios
may be worth more or less than its original cost. The investment policies of the
Portfolios may entail the following risk factors:
 
    - EQUITY SECURITIES. Each Portfolio may invest in equity securities. Prices
     of equity securities fluctuate in response to many factors, including the
     financial health of the issuer and changes in economic and market
     conditions.
 
    - REAL ESTATE INVESTING. Each Portfolio will invest in the securities of
     companies principally engaged in the real estate industry and may be
     subject to the risks associated with the direct ownership of real estate
     and investment in real estate investment trusts ("REITs"). Risks commonly
     associated with the direct ownership of real estate include fluctuations in
     the value of underlying properties and defaults by borrowers or tenants. In
     addition to these risks, REITs are dependent on specialized management
     skills and some REITs may have limited diversification, subjecting them to
     risks inherent in investments in a limited number of properties, in a
     narrow geographic area, or in a single property type.
 
    - FIXED INCOME SECURITIES. Each Portfolio will be subject to credit risk and
     market risk associated with investment in fixed income securities. Credit
     risk is the possibility that an issuer may be unable to meet scheduled
     principal and interest payments. Market risk is the possibility that a
     change in interest rates or the market's perception of the issuer's
     prospects may adversely affect the value of a fixed income security.
 
    - FOREIGN INVESTMENT. Each Portfolio may invest in the securities of foreign
     issuers. The risks of foreign investment include fluctuations in foreign
     currency values, political events affecting the country of issuance and
     potentially greater market volatility and lower liquidity.
 
    - EMERGING MARKET COUNTRY SECURITIES. The European Real Estate and Asian
     Real Estate Portfolios may invest in emerging market country securities
     which entail risks typically associated with investment in more established
     foreign markets. However, these risks may be intensified due to higher
     volatility and less liquidity of emerging markets, possible political risks
     associated with the country of issuance and generally weaker financial
     condition of issuers in these markets.
 
    - DERIVATIVES. Each Portfolio may invest in instruments that derive their
     values from those of specified securities, indices, currencies or other
     points of reference. These derivatives, including those used to manage
     risk, are themselves subject to the risks of the different markets in which
     they are traded and, therefore, may or may not serve their intended
     purposes.
 
For additional information about risk factors, see also "Investment Objectives
and Policies" and "Additional Investment Information."
 
                                       11
<PAGE>
                       INVESTMENT OBJECTIVES AND POLICIES
 
    The investment objective of each Portfolio is described below, together with
the policies each Portfolio will employ in its efforts to achieve its objective.
Each Portfolio's investment objective is a fundamental policy which may not be
changed without the approval of a majority of the Portfolio's outstanding voting
securities. There is no assurance that the Portfolios will attain their
objectives. The investment policies described below are non-fundamental policies
unless otherwise noted and may be changed without shareholder approval.
 
    Each of the Portfolios invests in equity securities of companies in the real
estate industry. Equity securities include common stocks, rights or warrants to
purchase common stocks, securities convertible into common stocks, preferred
stocks, equity-linked securities and shares or units of beneficial interest in
specialized ownership vehicles, such as property unit trusts and real estate
investment trusts ("REITs"). For purposes of each Portfolio's investment
policies, a company is principally engaged in the real estate industry if (i) it
derives at least 50% of its revenues or profits from the ownership,
construction, management, financing or sale of residential, commercial or
industrial real estate, or (ii) it has at least 50% of the fair market value of
its assets invested in residential, commercial or industrial real estate. For
example, companies in the real estate industry may include, among others: real
estate development companies, real estate operating companies, companies
principally engaged in the ownership of income-producing real property,
specialized ownership vehicles, and companies with substantial real estate
holdings, such as hotel companies, residential builders and land-rich companies.
In addition to the investments and strategies described below, the Portfolios
may invest in certain securities and obligations as set forth in "Additional
Investment Information" below.
 
EUROPEAN REAL ESTATE PORTFOLIO
 
    The investment objective of the European Real Estate Portfolio is to provide
current income and long-term capital appreciation by investing primarily in
equity securities of companies in the European real estate industry. The
Portfolio seeks to achieve its objective by investing primarily in securities of
European issuers, including those located in Germany, France, Switzerland,
Belgium, Italy, Spain, Portugal, Finland, Sweden, Denmark, Norway, Ireland and
the United Kingdom. Investments may also be made in equity securities of
companies located in the smaller and emerging markets of Europe.
 
    The Portfolio will invest primarily in securities which are traded on
recognized stock exchanges in Europe and in equity securities of companies
organized under the laws of a European country whose business is conducted
principally in Europe. The Portfolio may also invest in Depositary Receipts of
European issuers and, to the extent that they become available, REITs that
invest in Europe. At least 65% of the total assets of the Portfolio will be
invested in equity securities of companies principally engaged in the European
real estate industry. While the Portfolio is not limited in the portion of its
assets that may be invested in a single country, it currently intends to spread
its investments among several countries to reduce investment risk and currency
risk.
 
    The Portfolio's investments may include securities of companies located in
emerging countries and traded in emerging markets. These securities pose greater
liquidity risks and other risks than securities of companies located in
developed countries and traded in more established markets. For a description of
special considerations and certain risks associated with investment in foreign
issuers, see "Additional Investment Information."
 
                                       12
<PAGE>
ASIAN REAL ESTATE PORTFOLIO
 
    The investment objective of the Asian Real Estate Portfolio is to provide
long-term capital appreciation by investing primarily in equity securities of
companies in the Asian real estate industry. The Portfolio seeks to achieve its
objective by investing primarily in equity securities which are traded on
recognized stock exchanges in Asia and in equity securities of companies
organized under the laws of an Asian country whose business is conducted
principally in Asia. The Portfolio may also invest in Depositary Receipts of
Asian issuers and, to the extent that they become available, REITs that invest
in Asia.
 
    The Portfolio will invest primarily in the more established Asian markets,
including Singapore, Malaysia, Hong Kong and Thailand, but additional
opportunities also are sought in markets such as South Korea and Taiwan and
other emerging markets that are open to foreign investment. In addition, the
Portfolio may invest in Japan, Australia and New Zealand. At least 65% of the
total assets of the Portfolio will be invested in equity securities of companies
principally engaged in the Asian real estate industry. While the Portfolio is
not limited in the portion of its assets that may be invested in a single
country, it currently intends to spread its investments among several countries
to reduce investment risk and currency risk. Allocation of investments will
depend on the relative attractiveness of the stocks of companies in the
respective countries. Government regulation and restrictions in many of the
countries of Asia may limit the amount, mode and extent of investment in
companies of such countries.
 
    The Portfolio's investments will include securities of companies located in
emerging countries and traded in emerging markets. These securities pose greater
liquidity risks and other risks than securities of companies located in
developed countries and traded in more established markets. For a description of
special considerations and certain risks associated with investment in foreign
issuers, see "Additional Investment Information."
 
U.S. REAL ESTATE PORTFOLIO
 
    The investment objective of the U.S. Real Estate Portfolio is to provide
above-average current income and long-term capital appreciation by investing
primarily in equity securities of companies in the U.S. real estate industry,
including substantial investment in REITs. Under normal circumstances, at least
65% of the Portfolio's total assets will be invested in income producing equity
securities of U.S. and non-U.S. companies principally engaged in the U.S. real
estate industry. The Portfolio seeks to invest in equity securities of companies
that provide a dividend yield that exceeds the composite dividend yield of
securities comprising the S&P 500.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    CONVERTIBLE SECURITIES, WARRANTS AND EQUITY-LINKED SECURITIES.  The
Portfolios may invest in securities such as convertible securities, preferred
stock, warrants or other securities exchangeable under certain circumstances for
shares of common stock. Warrants are instruments giving holders the right, but
not the obligation, to buy shares of a company at a given price during a
specified period. The Portfolios may also invest in equity-linked securities,
which are securities that are convertible into, or the value of which is based
upon the value of, equity securities upon certain terms and conditions. The
amount received by an investor at maturity of such securities is not fixed but
is based on the price of the underlying common stock. It is impossible to
predict whether the price of the underlying common stock will rise or fall.
Trading prices of the underlying common stock will be influenced by the issuer's
operational results, by complex, interrelated political, economic, financial, or
other factors affecting the capital markets, the stock exchanges on which the
underlying common
 
                                       13
<PAGE>
stock is traded and the market segment of which the issuer is a part. In
addition, it is not possible to predict how equity-linked securities will trade
in the secondary market, although the market for such securities is fairly
developed and generally liquid. The market for such securities may be shallow,
however, and high volume trades may be possible only with discounting. In
addition to the foregoing risks, the return on such securities depends on the
creditworthiness of the issuer of the securities, which may be the issuer of the
underlying securities or a third party investment banker or other lender. The
creditworthiness of such third party issuer of equity-linked securities may, and
often does, exceed the creditworthiness of the issuer of the underlying
securities. The advantage of using equity-linked securities over traditional
equity and debt securities is that the former are income-producing vehicles that
may provide a higher income than the dividend income on the underlying equity
securities while allowing some participation in the capital appreciation of the
underlying equity securities. Another advantage of using equity-linked
securities is that they may be used for hedging to reduce the risk of investing
in the generally more volatile underlying equity securities.
 
    DEPOSITARY RECEIPTS.  The Portfolios may invest in Depositary Receipts,
including American Depositary Receipts ("ADRs"), Global Depositary Receipts
("GDRs"), European Depositary Receipts ("EDRs") and other Depositary Receipts
(which, together with ADRs, GDRs and EDRs, are hereinafter collectively referred
to as "Depositary Receipts"), to the extent that such Depositary Receipts are or
become available. ADRs are securities, typically issued by a U.S. financial
institution (a "depositary"), that evidence ownership interests in a security or
a pool of securities issued by a foreign issuer (the "underlying issuer") and
deposited with the depositary. ADRs may be "sponsored" or "unsponsored."
Sponsored ADRs are established jointly by a depositary and the underlying
issuer, whereas unsponsored ADRs may be established by a depositary without
participation by the underlying issuer. The issuers of the stock of unsponsored
ADRs are not obligated to disclose material information in the United States
and, therefore, there may not be a correlation between such information and the
market value of the ADR. GDRs, EDRs and other types of Depositary Receipts are
typically issued by foreign depositaries, although they may also be issued by
U.S. depositaries, and evidence ownership interests in a security or pool of
securities issued by either a foreign or a U.S. corporation. Generally,
Depositary Receipts in registered form are designed for use in the U.S.
securities market and Depositary Receipts in bearer form are designed for use in
securities markets outside the United States. The Portfolios may invest in
sponsored and unsponsored Depositary Receipts. For purposes of the Portfolios'
investment policies, the Portfolios' investments in Depositary Receipts will be
deemed to be investments in the underlying securities.
 
    FIXED INCOME SECURITIES.  Under normal circumstances, each Portfolio may
invest up to 35% of its total assets in (i) debt securities issued or guaranteed
by real estate companies or secured by real estate assets which are, at the time
of purchase, rated investment grade by a nationally recognized statistical
rating organization ("NRSRO") or determined by the Adviser to be of comparable
quality, and (ii) high-grade debt securities, consisting of corporate debt
securities and U.S. and foreign government securities. Investment grade
securities are securities that are rated in one of the four highest rating
categories by an NRSRO. Securities rated in the lowest category of investment
grade securities have speculative characteristics. Although a Portfolio is not
required to sell securities whose quality declines below investment grade, the
Adviser will consider such quality in determining whether to maintain the
Portfolio's investment in such securities. The market value of the fixed income
securities in which a Portfolio invests will be affected by changes in the
creditworthiness of issuers and will change in response to interest rate changes
and other factors. Generally, the values of fixed income securities vary
inversely with changes in interest rates, so that during periods of falling
interest rates, the values of outstanding fixed income securities generally rise
and during periods of rising interest rates, the values of
 
                                       14
<PAGE>
such securities generally decline. Changes in the value of portfolio securities
will not necessarily affect cash income derived from these securities, but will
affect a Portfolio's net asset value. While securities with longer maturities
tend to produce higher yields, the prices of longer maturity securities are
subject to greater market fluctuations as a result of changes in interest rates.
 
    FOREIGN CURRENCY FORWARD CONTRACTS.  The Portfolios may enter into foreign
currency forward contracts ("forward contracts") that provide for the purchase
or sale of an amount of a specified currency at a future date. The Portfolios
may use such contracts to protect against a decline in a foreign currency
against the U.S. dollar between the trade date and settlement date when the
Portfolio purchases or sells securities, lock in the U.S. dollar value of
dividends and interest on securities held by the Portfolio, and generally to
protect the U.S. dollar value of securities held by the Portfolio against
exchange rate fluctuation. While forward contracts may limit losses as a result
of exchange rate fluctuations, they will also limit any gains that might
otherwise have been realized. The Portfolio's Custodian may be required to place
cash or liquid securities in a segregated account in an amount equal to the
value of the Portfolio's total assets committed to the consummation of forward
contracts. If the value of the securities placed in the segregated account
declines, additional cash or securities will be placed in the account on a daily
basis so that the value of the account will be at least equal to the amount of
the Portfolio's commitments with respect to such contracts. The Portfolios may
also invest in currency options, futures and options on futures. See "Derivative
Instruments" below.
 
    FOREIGN INVESTMENT.  Each Portfolio may invest in the securities of foreign
issuers. Investment in securities of foreign issuers involves investment risks
somewhat different from those affecting securities of U.S. issuers. The
Portfolio's investments will be subject to political and economic events that
affect the countries in which it invests. Foreign issuers may be subject to
different accounting, auditing and financial standards and requirements. There
also may be less government supervision and regulation of foreign securities
exchanges, brokers and listed companies than in the United States. Many foreign
securities markets have substantially less trading volume than U.S. national
securities exchanges and, therefore, securities of some foreign issuers are less
liquid and more volatile than securities of comparable U.S. issuers. Brokerage
commissions and other transaction costs on foreign securities exchanges are
generally higher than in the United States. Dividends and interest paid by
foreign issuers may be subject to withholding and other foreign taxes, which may
decrease the net return on foreign investments as compared to dividends and
interest paid to the Portfolios by domestic companies. Investments in securities
of foreign issuers are generally denominated in foreign currencies and, since a
Portfolio may temporarily hold uninvested reserves in bank deposits in foreign
currencies, the value of a Portfolio's assets as measured in U.S. dollars may be
affected favorably or unfavorably by changes in currency exchange rates and
exchange control regulations, and a Portfolio may incur costs in connection with
conversions between various currencies.
 
    The European Real Estate and Asian Real Estate Portfolios may also invest in
emerging market country securities. Investing in emerging markets entails the
risks associated with foreign investment described above, however, these risks
may be intensified in emerging markets. Emerging markets can include every
nation in the world except the United States, Canada, Japan, Australia, New
Zealand and most nations located in Western Europe. Certain emerging market
countries have historically experienced, and may continue to experience, high
rates of inflation, high interest rates, exchange rate fluctuations, large
amounts of external debt, trade difficulties and unemployment. Further, the
economies of developing countries generally are heavily dependent upon
international trade and, accordingly, have been, and may continue to be,
adversely affected by trade
 
                                       15
<PAGE>
barriers, exchange controls and other protectionist measures imposed or
negotiated by the countries in which they trade. There also are risks associated
with the possibility of nationalization, expropriation or confiscatory taxation,
political changes, government regulation, social instability or diplomatic
developments (including war) that could adversely affect the economies of such
countries or the value of a Portfolio's investments in those countries.
 
    The Asian Real Estate Portfolio may invest in securities of issuers located
in Hong Kong. Hong Kong was established as a British colony in the 1840's and,
until recently, was governed by Great Britain through an appointed Governor.
Effective July 1, 1997, Hong Kong reverted to Chinese sovereignty and is
governed as a Special Administrative Region of China. Although China has made
certain commitments to preserve the economic and social freedoms enjoyed in Hong
Kong during British rule, there can be no assurances that China's commitments
will be maintained. Action taken by the Chinese government which limits or
causes uncertainty with regard to these economic and social freedoms could have
an adverse affect on the Portfolio's investments in securities of issuers
located in Hong Kong.
 
    INVESTMENT FUNDS.  Some emerging countries have laws and regulations that
currently preclude direct foreign investment in the securities of their
companies. However, indirect foreign investment in the securities of companies
listed and traded on the stock exchanges in these countries is permitted by
certain emerging countries through investment funds which have been specifically
authorized. The Portfolios may invest in these investment funds subject to the
provisions of the Investment Company Act of 1940, as amended (the "1940 Act")
and other applicable laws. If a Portfolio invests in such investment funds, the
Portfolio's shareholders will bear not only their proportionate share of the
expenses of the Portfolio (including operating expenses and the fees of the
Adviser), but also will indirectly bear similar expenses of the underlying
investment funds.
 
    Certain of the investment funds referred to in the preceding paragraph are
advised by the Adviser. The Portfolios may, to the extent permitted under the
1940 Act and other applicable law, invest in these investment funds. If a
Portfolio elects to make an investment in such an investment fund, it will only
purchase the securities of such investment fund in the secondary market.
 
    LOANS OF PORTFOLIO SECURITIES.  Each Portfolio may lend its securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing net investment income. These loans must be secured
continuously by cash or equivalent collateral, or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be a risk of delay in recovery of the securities or even loss
of rights in the collateral should the borrower of the securities fail
financially. Each Portfolio will not enter into securities loan transactions
exceeding, in the aggregate, 33 1/3% of the market value of its total assets.
 
    MONEY MARKET INSTRUMENTS.  The Portfolios are permitted to invest in money
market instruments, although the Portfolios intend to stay invested in
securities satisfying their primary investment objectives to the extent
practical. Consistent with their investment policies, the Portfolios may make
money market investments pending other investment or settlement for liquidity.
In addition, the Portfolios may invest in money market instruments for temporary
defensive purposes during adverse market conditions. The money market
investments permitted for the Portfolios include: obligations of the U.S.
Government and its agencies and instrumentalities, commercial paper, bank
obligations (including certificates of deposit), other debt securities and
repurchase agreements.
 
                                       16
<PAGE>
    NON-PUBLICLY TRADED SECURITIES, PRIVATE PLACEMENTS AND RESTRICTED
SECURITIES.  Each Portfolio may invest in securities that are neither listed on
a stock exchange nor traded over-the-counter. Such unlisted equity securities
may involve a higher degree of business and financial risk that can result in
substantial losses. As a result of the absence of a public trading market for
these securities, they may be less liquid than publicly traded securities.
Although these securities may be resold in privately negotiated transactions,
the prices realized from these sales could be less than those originally paid by
the Portfolio or less than what may be considered the fair value of such
securities. Further, companies whose securities are not publicly traded may not
be subject to the disclosure and other investor protection requirements which
might be applicable if their securities were publicly traded. If such securities
are required to be registered under the securities laws of one or more
jurisdictions before being resold, the Portfolio may be required to bear the
expenses of registration.
 
    As a general matter, each Portfolio may not invest more than 15% of its net
assets in illiquid securities, including securities for which there is no
readily available secondary market. Securities that are not registered under the
Securities Act of 1933, as amended (the "1933 Act"), but that can be offered and
sold to qualified institutional buyers under Rule 144A under the 1933 Act ("Rule
144A Securities") will not be included within the foregoing 15% restriction if
the securities are determined to be liquid. The Board of Directors has adopted
guidelines and delegated to the Adviser, subject to the supervision of the Board
of Directors, the daily function of determining and monitoring the liquidity of
Rule 144A Securities. Rule 144A Securities may become illiquid if qualified
institutional buyers are not interested in acquiring the securities.
 
    REITS.  A substantial portion of the U.S. Real Estate Portfolio's total
assets will be invested in securities of REITs. The European Real Estate and
Asian Real Estate Portfolios may also, to the extent they become available,
invest in REITs that invest in Europe or Asia, respectively. REITs pool
investors' funds for investment primarily in income producing real estate or
real estate related loans or interests. A REIT is not taxed on income
distributed to its shareholders or unitholders if it complies with regulatory
requirements relating to its organization, ownership, assets and income, and
with a regulatory requirement that it distribute to its shareholders or
unitholders at least 95% of its taxable income for each taxable year. Generally,
REITs can be classified as Equity REITs, Mortgage REITs or Hybrid REITs. Equity
REITs invest the majority of their assets directly in real property and derive
their income primarily from rents and capital gains from appreciation realized
through property sales. Equity REITs are further categorized according to the
types of real estate securities they own, e.g., apartment properties, retail
shopping centers, office and industrial properties, hotels, health-care
facilities, manufactured housing and mixed-property types. Mortgage REITs invest
the majority of their assets in real estate mortgages and derive their income
primarily from interest payments. Hybrid REITs combine the characteristics of
both Equity and Mortgage REITs. The U.S. Real Estate Portfolio will invest
primarily in Equity REITs.
 
    A shareholder in any of the Portfolios should realize that, by investing in
REITs indirectly through the Portfolio, he will bear not only his proportionate
share of the expenses of the Portfolio, but also, indirectly, the management
expenses of underlying REITs. Because it is expected that the U.S. Real Estate
Portfolio will invest a substantial portion of its assets in REITs and the
European Real Estate and Asian Real Estate Portfolios may invest a portion of
their assets in REITs, the Portfolios will also be subject to certain risks
associated with the direct investments of REITs. REITs may be affected by
changes in the value of their underlying properties and by defaults by borrowers
or tenants. Mortgage REITs may be affected by the quality of the credit
extended.
 
                                       17
<PAGE>
Furthermore, REITs are dependent on specialized management skills. Some REITs
may have limited diversification and may be subject to risks inherent in
investments in a limited number of properties, in a narrow geographic area, or
in a single property type. REITs depend generally on their ability to generate
cash flow to make distributions to shareholders or unitholders, and may be
subject to defaults by borrowers and to self-liquidations. In addition, the
performance of a REIT may be affected by its failure to qualify for tax-free
pass-through of income under the Internal Revenue Code of 1986, as amended (the
"Code"), or its failure to maintain exemption from registration under the 1940
Act.
 
    REAL ESTATE INVESTING.  Each of the Portfolios invests primarily in equity
securities of issuers engaged in the real estate industry, which entails certain
risks and considerations of which an investor should be aware. In particular,
securities of such issuers may be subject to the risks associated with the
direct ownership of real estate. These risks include: the cyclical nature of
real estate values, risks related to general and local economic conditions,
overbuilding and increased competition, increases in property taxes and
operating expenses, demographic trends and variations in rental income, changes
in zoning laws, casualty or condemnation losses, environmental risks, regulatory
limitations on rents, changes in neighborhood values, changes in the appeal of
properties to tenants, increases in interest rates and other real estate capital
market influences. Generally, increases in interest rates will increase the
costs of obtaining financing, which could directly and indirectly decrease the
value of the Portfolios' investments.
 
    REPURCHASE AGREEMENTS.  The Portfolios may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines established by
the Fund's Board of Directors. In a repurchase agreement, the Portfolio buys a
security from a seller that has agreed to repurchase it at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of the
agreement. The term of these agreements is usually from overnight to one week,
and never exceeds one year. A repurchase agreement may be viewed as a fully
collateralized loan of money by the Portfolio to the seller. The Portfolio
always receives securities with a market value at least equal to the purchase
price (including accrued interest) as collateral and this value is maintained
during the term of the agreement. If the seller defaults and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with respect to the seller, the Portfolio's realization upon the
collateral may be delayed or limited. The Portfolios may not enter into
repurchase agreements with more than seven days to maturity if, as a result,
more than 15% of the market value of the Portfolio's net assets are invested in
these agreements and other investments for which market quotations are not
readily available or which are otherwise illiquid.
 
    SPECIALIZED OWNERSHIP VEHICLES.  Each Portfolio may invest in specialized
ownership vehicles which pool investors' funds for investment primarily in
income-producing real estate or real estate related loans or interests. Such
specialized ownership vehicles in which the Portfolios may invest include
property unit trusts, REITs and other similar specialized investment vehicles.
Investments in such specialized ownership vehicles may have favorable or
unfavorable legal, regulatory or tax implications for a Portfolio and, to the
extent such vehicles are structured similarly to investment funds, may cause the
Portfolios' shareholders to indirectly bear certain additional operating
expenses.
 
    TEMPORARY INVESTMENTS.  During periods in which the Adviser believes changes
in economic, financial or political conditions make it advisable, each Portfolio
may, for temporary defensive purposes, invest up to 100% of its total assets in
certain short-term and medium-term debt obligations or hold cash. The short-term
and
 
                                       18
<PAGE>
medium-term debt obligations in which a Portfolio may invest consist of (i)
obligations of the U.S. or foreign governments, their respective agencies or
instrumentalities; (ii) money market instruments; and (iii) instruments
denominated in any currency issued by international development agencies.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  The Portfolios may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Delivery of and payment for these securities may take
as long as a month or more after the date of the purchase commitment, but will
take place no more than 120 days after the trade date. The Portfolios will
maintain with the Custodian a segregated account of cash or liquid securities in
an amount at least equal to these commitments. The payment obligation and the
interest rates that will be received are each fixed at the time the Portfolio
enters into the commitment and no interest accrues to the Portfolio until
settlement. Thus, it is possible that the market value at the time of settlement
could be higher or lower than the purchase price if the general level of
interest rates has changed. It is a current policy of the Portfolios not to
enter into when-issued commitments exceeding, in the aggregate, 15% of the
market value of the Portfolio's total assets less liabilities other than the
obligations created by these commitments.
 
DERIVATIVE PRODUCTS (DERIVATIVES)
 
    The Portfolios are permitted to utilize various exchange-traded and
over-the-counter derivative instruments and derivative securities, both for
hedging and non-hedging purposes. Permitted derivative products include, but are
not limited to: futures contracts ("futures"); forward contracts ("forwards");
options; swaps, caps, collars and floors; structured notes; and other derivative
products yet to be developed, so long as these new products are used in a manner
consistent with the objectives of the Portfolios. These derivative products may
be based upon a wide variety of underlying rates, indices, instruments,
securities and other products, such as interest rates, foreign currencies,
foreign and domestic fixed income and equity securities, groups or "baskets" of
securities and securities indices (for each derivative product, the
"underlying"). Exclusive of forward foreign currency contracts and any
derivative products used for hedging purposes, each Portfolio will limit its use
of derivative products to 33 1/3% of its total assets, measured by the aggregate
notional amount of outstanding derivative products.
 
    The Portfolios may use derivative products under a number of different
circumstances to further their investment objectives. For example, a Portfolio
may purchase derivatives to gain exposure to a market quickly in response to
changes in the Portfolio's investment strategy, upon the inflow of investable
cash or when the derivative provides greater liquidity than the underlying
market. A Portfolio may also use derivatives when it is restricted from directly
owning the "underlying" or when derivatives provide a pricing advantage or lower
transaction costs. The Portfolios also may purchase combinations of derivatives
in order to gain exposure to an investment in lieu of actually purchasing such
investment. Derivatives may also be used by a Portfolio for hedging or risk
management purposes and in other circumstances when the Adviser believes it
advantageous to do so consistent with the Portfolio's investment objectives and
policies. The Portfolios will not use derivatives in a manner that creates
leverage, except to the extent that the use of leverage is expressly permitted
by a particular Portfolio's investment policies, and then only in a manner
consistent with such policies.
 
                                       19
<PAGE>
    The use of derivative products is a highly specialized activity which
involves investment techniques and risks different from those associated with
ordinary portfolio securities transactions. If the Adviser is incorrect in
forecasts of market values, interest rates, and currency exchange rates, the
investment performance of the Portfolios will be less favorable than it would
have been if these investment techniques had not been used.
 
    Some of the derivative products in which the Portfolios may invest and some
of the risks related thereto are described in more detail below.
 
FUTURES CONTRACTS (FUTURES) AND FORWARD CONTRACTS (FORWARDS)
 
    The Portfolios may purchase and sell futures contracts, such as futures on
securities indices, baskets of securities, foreign currencies and interest rates
of the type generally known as financial futures. These are standardized
contracts that are bought and sold on organized exchanges. A futures contract
obligates a party to buy or sell a specific amount of the "underlying," such as
for example, a particular foreign currency, on a specified future date at a
specified price or to settle the value in cash.
 
    The Portfolios may also purchase and sell forward contracts, such as forward
rate agreements and other financial forward contracts. The Portfolios may also
use foreign currency forward contracts which are separately discussed elsewhere
in this Prospectus. See "Foreign Currency Forward Contracts" above. These
forward contracts are privately negotiated and are bought and sold in the
over-the-counter market. Like a future, a forward contract obligates a party to
buy or sell a specific amount of the underlying on a specified future date at a
specified price. The terms of the forward contract are customized. Forward
contracts, like other over-the-counter contracts that are negotiated directly
with an individual counterparty, subject the Portfolio to the risk of
counterparty default.
 
    In some cases, the Portfolios may be able to use either futures contracts,
forward contracts or exchange-traded or over-the-counter options to accomplish
similar purposes. In all cases, the Portfolios will use these products only as
permitted by applicable laws and regulations. Some of the ways in which the
Portfolios may utilize futures contracts, forward contracts and related options
are as follows:
 
    The Portfolios may sell securities index futures contracts and/or index
options thereon in anticipation of or during a market decline to attempt to
offset the decrease in market value of investments in its portfolio, or may
purchase securities index futures or options in order to gain market exposure.
There currently are limited securities index futures and options on such futures
in many countries, particularly emerging countries. The nature of the strategies
adopted by the Adviser, and the extent to which those strategies are used, may
depend on the development of such markets. The Portfolios may also purchase and
sell foreign currency futures to hedge their respective holdings and commitments
against changes in the level of future currency rates or to adjust their
exposure to a particular currency.
 
    The Portfolios may engage in transactions in interest rate futures and
related products. The value of these contracts rises and falls inversely with
changes in interest rates. The Portfolios may engage in such transactions to
hedge their holdings of debt instruments against future changes in interest
rates or for other purposes.
 
    The Portfolios may also purchase or sell futures and forwards on other
financial instruments, such as U.S. Government securities and certificates of
deposit. The value of these contracts also rises and falls inversely with
changes in interest rates. The Portfolios may engage in financial futures and
forward contracts for both hedging and non-hedging purposes.
 
                                       20
<PAGE>
    Gains and losses on futures contracts, forward contracts and related options
depend on the Adviser's ability to predict correctly the direction of securities
prices, interest rates and other economic factors. Other risks associated with
the use of these instruments include (i) imperfect correlation between the
change in market value of investments held by a Portfolio and the prices of
derivative products relating to investments purchased or sold by the Portfolio,
and (ii) possible lack of a liquid secondary market for a derivative product and
the resulting inability to close out a position. The risk that a Portfolio will
be unable to close out a position will be minimized by only entering into
transactions for which there appears to be a liquid exchange or secondary
market. In some strategies, the risk of loss in trading on futures and related
transactions can be substantial, due both to the low margin deposits required
and the extremely high degree of leverage involved in pricing.
 
    Under rules adopted by the Commodity Futures Trading Commission (the
"CFTC"), each Portfolio may, without registering with the CFTC as a Commodity
Pool Operator, enter into futures contracts and options thereon for both hedging
and non-hedging purposes, provided that not more than 5% of such Portfolio's
total assets at the time of entering the transaction are required as margin and
option premiums to secure obligations under such contracts relating to non-bona
fide hedging activities.
 
OPTION TRANSACTIONS
 
    The Portfolios may seek to increase their returns or may hedge their
portfolio investments through options transactions with respect to individual
securities, indices or baskets in which such Portfolios may invest; other
financial instruments; and foreign currency. Various options may be purchased
and sold on either the exchange-traded or over-the-counter markets.
 
    Each Portfolio may purchase put and call options. Purchasing a put option
gives a Portfolio the right, but not the obligation, to sell the underlying
(such as a securities index or a particular foreign currency) at the exercise
price either on a specific date or during a specified exercise period.
Purchasing a call option gives a Portfolio a similar right, but not the
obligation, to purchase the underlying. The purchaser pays a premium to the
seller (also known as the writer) of the option.
 
    Each Portfolio also may write put and call options on investments held in
its portfolio, as well as foreign currency options. A Portfolio that has written
an option receives a premium that increases the Portfolio's return on the
underlying in the event the option expires unexercised or is closed out at a
profit. However, by writing a call option, a Portfolio will limit its
opportunity to profit from an increase in the market value of the underlying
above the exercise price of the option. By writing a put option, a Portfolio
will be exposed to the amount by which the price of the underlying is less than
the strike price.
 
    By writing an option, a Portfolio incurs an obligation either to buy (in the
case of a put option) or sell (in the case of a call option) the underlying from
the purchaser of the option at the option's exercise price, upon exercise by the
purchaser. Pursuant to guidelines established by the Board of Directors, the
Portfolios may only write options that are "covered." A covered call option
means that until the expiration of the option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will continue to own (i) the underlying; (ii) securities or instruments
convertible or exchangeable without the payment of any consideration into the
underlying; or (iii) a call option on the same underlying with a strike price no
higher than the price at which the underlying was sold pursuant to a short
option position. In the case of a put option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will own another put option on the same underlying with an equal or higher
strike price.
 
                                       21
<PAGE>
    There currently are limited options markets in many countries, particularly
emerging market countries, and the nature of the strategies adopted by the
Adviser and the extent to which those strategies are used will depend on the
development of these options markets. The primary risks associated with the
Portfolios' use of options as described include (i) imperfect correlation
between the change in market value of investments held, purchased or sold by a
Portfolio and the prices of options relating to such investments, and (ii)
possible lack of a liquid secondary market for an option.
 
INTEREST RATE, CURRENCY, COMMODITY AND EQUITY SWAPS, CAPS, COLLARS AND FLOORS
 
    Swaps are privately negotiated over-the-counter derivative products in which
two parties agree to exchange payment streams calculated in relation to a rate,
index, instrument or certain securities and a particular "notional amount." As
with many of the other derivative products available to the Portfolios, the
underlying may include an interest rate (fixed or floating), a currency exchange
rate, a commodity price index, and a security, securities index or a combination
thereof. A great deal of flexibility is possible in the way the products may be
structured, with the effect being that the parties may have exchanged amounts
equal to the return on one rate, index or group of securities for another. For
example, in a simple fixed-to-floating interest rate swap, one party makes
payments equivalent to a fixed interest rate, and the other makes payments
equivalent to a specified interest rate index. A Portfolio may engage in simple
or more complex swap transactions involving a wide variety of underlyings. The
currency swaps that the Portfolios may enter will generally involve an agreement
to pay interest streams in one currency based on a specified index in exchange
for receiving interest streams denominated in another currency. Such swaps may
involve initial and final exchanges that correspond to the agreed upon notional
amount.
 
    Caps, collars and floors are privately-negotiated option-based derivative
products. A Portfolio may use one or more of these products in addition to or in
lieu of a swap involving a similar rate or index. As in the case of a put or
call option, the buyer of a cap or floor pays a premium to the writer. In
exchange for that premium, the buyer receives the right to a payment equal to
the differential if the specified index or rate rises above (in the case of a
cap) or falls below (in the case of a floor) a pre-determined strike level. As
in the case of swaps, obligations under caps and floors are calculated based
upon an agreed notional amount, and like most swaps (other than foreign currency
swaps), the entire notional amount is not exchanged and thus is not at risk. A
collar is a combination product in which the same party, such as the Portfolio,
buys a cap from and sells a floor to the other party. As with put and call
options, the amount at risk is limited for the buyer, but, if the cap or floor
is not hedged or covered, may be unlimited for the seller. Under current market
practice, caps, collars and floors between the same two parties are generally
documented under the same "master agreement." In some cases, options and forward
agreements may also be governed by the same master agreement. In the event of a
default, amounts owed under all transactions entered into under, or covered by,
the same master agreement would be netted and only a single payment would be
made.
 
    Swaps, caps, collars and floors are credit-intensive products. A Portfolio
that enters into a swap transaction bears the risk of default, i.e. nonpayment,
by the other party. The guidelines under which each Portfolio enters derivative
transactions, along with some features of the transactions themselves, are
intended to reduce these risks to the extent reasonably practicable, although
they cannot eliminate the risks entirely. Under guidelines established by the
Board of Directors, a Portfolio may enter into swaps only with parties that meet
certain credit rating guidelines. Consistent with current market practices, a
Portfolio will generally enter into swap transactions on a net basis, and all
swap transactions with the same party will be documented under a single master
 
                                       22
<PAGE>
agreement to provide for net payment upon default. In addition, a Portfolio's
obligations under an agreement will be accrued daily (offset against any amounts
owing to the Portfolio) and any accrued, but unpaid, net amounts owed to the
other party to a master agreement will be covered by the maintenance of a
segregated account consisting of cash or liquid securities.
 
    Interest rate and total rate of return (fixed income or equity) swaps
generally do not involve the delivery of securities, other underlying assets, or
principal. In such case, if the other party to an interest rate or total rate of
return swap defaults, a Portfolio's risk of loss will consist of the payments
that a Portfolio is contractually entitled to receive from the other party. This
may not be true for currency swaps that require the delivery of the entire
notional amount of one designated currency in exchange for the other. If there
is a default by the other party, a Portfolio may have contractual remedies
pursuant to the agreements related to the transaction.
 
STRUCTURED NOTES
 
    Structured notes are derivative securities for which the amount of principal
repayment and/or interest payments is based upon the movement of one or more
factors. These factors include, but are not limited to, currency exchange rates,
interest rates (such as the prime lending rate and LIBOR) and stock indices,
such as the S&P 500. In some cases, the impact of the movements of these factors
may increase or decrease through the use of multipliers or deflators. The
Portfolios may use structured notes to tailor their investments to the specific
risks and returns the Adviser wishes to accept while avoiding or reducing
certain other risks.
 
                             INVESTMENT LIMITATIONS
 
    As non-diversified investment companies, the Portfolios are not limited by
the 1940 Act in the proportion of their assets that may be invested in the
obligations of a single issuer. Thus, each Portfolio may invest a greater
proportion of its assets in the securities of a smaller number of issuers and,
as a result, will be subject to greater risk with respect to its portfolio
securities. Any economic, political, or regulatory developments affecting the
value of the securities the Portfolio holds could have a greater impact on the
total value of the Portfolio's holdings than would be the case if the
Portfolio's securities were diversified among more issuers. The Portfolios,
however, intend to comply with the diversification requirements imposed by the
Code for qualification as regulated investment companies. In addition, each
Portfolio will concentrate in the real estate industry, but will not invest more
than 25% of its total assets in the securities of companies in any one other
industry (for these purposes the U.S. Government and its agencies and
instrumentalities are not considered an industry). See "Investment Limitations"
in the Statement of Additional Information.
 
    Each Portfolio operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of the
holders of a majority of the Portfolio's outstanding shares and under certain
non-fundamental investment limitations that may be changed without shareholder
approval. For additional information on fundamental and non-fundamental
limitations, see "Investment Limitations" in the Statement of Additional
Information.
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and each Portfolio. The Adviser provides investment
advice and portfolio management services pursuant to an Investment Advisory
Agreement and, subject to the supervision of the Fund's Board of Directors,
makes
 
                                       23
<PAGE>
each Portfolio's day-to-day investment decisions, arranges for the execution of
portfolio transactions and generally manages each Portfolio's investments. Set
forth below as an annual percentage of average daily net assets are the
management fees payable to the Adviser quarterly by each Portfolio pursuant to
terms of the Investment Advisory Agreement. The Adviser has voluntarily agreed
to a reduction in the fees payable to it and to reimburse the Portfolios, if
necessary, if such fees would cause total annual operating expenses of the
Portfolios to exceed the maximums set forth in the table below.
 
<TABLE>
<CAPTION>
                                                                                            MAXIMUM TOTAL OPERATING
                                                                                           EXPENSES AFTER FEE WAIVERS
                                                                                           --------------------------
PORTFOLIO                                                               MANAGEMENT FEE       CLASS A       CLASS B
- --------------------------------------------------------------------  -------------------  ------------  ------------
<S>                                                                   <C>                  <C>           <C>
European Real Estate Portfolio......................................           0.80%             1.00%         1.25%
Asian Real Estate Portfolio.........................................           0.80%             1.00%         1.25%
U.S. Real Estate Portfolio..........................................           0.80%             1.00%         1.25%
</TABLE>
 
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to customers in the
United States and abroad. Morgan Stanley Dean Witter & Co. ("MSDW") is the
direct parent of the Adviser and Morgan Stanley. MSDW is a preeminent global
financial services firm that maintains leading market positions in each of its
three primary businesses -- securities, asset management and credit services. At
March 31, 1998, the Adviser, together with its affiliated institutional asset
management companies, managed assets of approximately $166 billion, including
assets under fiduciary advice. See "Management of the Fund" in the Statement of
Additional Information.
 
    PORTFOLIO MANAGERS.  The following individuals have primary portfolio
management responsibility for the Portfolios noted below:
 
    EUROPEAN REAL ESTATE PORTFOLIO. -- JAN WILLEM DE GEUS.  Jan Willem de Geus
joined the Adviser in 1997. He is responsible for the Adviser's real estate
investment management business in Europe, with a focus on real estate securities
research. He has had primary management responsibility for the Portfolio since
it commenced operations. Before joining the Adviser, he was employed at the
Dutch Metalworkers Pensionfund (MPMA), where he worked for four years in the
international real estate department. At the MPMA he was involved in the
acquisition of direct real estate, was responsible for selecting REIT managers
in the United States, and was a portfolio manager of international real estate
securities. He graduated from the University of Nijmegen in 1991 with a
doctorate in city planning with a specialization in real estate and received a
masters degree in real estate investment from the Pennsylvania State University
in 1993. He is currently in the final stage of finishing his RBA (the Dutch
equivalent of an American CFA).
 
    ASIAN REAL ESTATE PORTFOLIO. -- KIAT SENG SEAH.  Kiat Seng Seah joined the
Adviser's Singapore office in 1990 as a portfolio manager/analyst specializing
in the Southeast Asian markets. He is currently a Principal and is responsible
for investments in Taiwan, Korea and Singapore. He has had primary management
responsibility for the Portfolio since it commenced operations. Previously, Kiat
Seng worked at Barclays de Zoete Wedd (BZW), where he was a senior investment
analyst, with particular responsibility for coverage of the real estate sectors
in Singapore and Malaysia, and helped pioneer BZW's research effort in
Singapore. Kiat Seng is a Chartered Financial Analyst and a qualified real
estate valuer who spent a total of four years as a real estate
 
                                       24
<PAGE>
appraiser, first for the New Zealand Government and then for the Singapore
Ministry of Finance. He was a Colombo Plan Scholar at the University of
Auckland, New Zealand and graduated with a degree in Property Administration.
 
    U.S. REAL ESTATE PORTFOLIO. -- RUSSELL C. PLATT AND THEODORE R.
BIGMAN.  Russell C. Platt joined Morgan Stanley in 1982 and currently is a
Managing Director of the Adviser. Mr. Platt has primary responsibility for
managing the real estate securities investment business for the Adviser and
serves as a member of the Investment Committee of The Morgan Stanley Real Estate
Fund ("MSREF"). Previously, Mr. Platt served as a Director of MSREF, where he
was involved in capital raising, acquisitions, oversight of investments and
investor relations. From 1991 to 1993, Mr. Platt was head of Morgan Stanley's
Transaction Development Group, which was responsible for identifying and
structuring real estate investment opportunities for the Firm and its clients
worldwide. From 1990 to 1991, Mr. Platt was based in Morgan Stanley Realty's
London office, where he was responsible for European transaction development.
Prior to this, he had extensive transaction responsibilities involving
portfolio, retail, office, hotel and apartment sales and financings. Mr. Platt
graduated from Williams College in 1982 with a B.A. in Economics and received
his M.B.A. from Harvard Business School in 1986.
 
    Theodore R. Bigman joined Morgan Stanley in 1995 and currently is a
Principal of the Adviser. Together with Russell Platt, he is responsible for the
Adviser's real estate securities research. Prior to joining the Adviser, he was
a Director at CS First Boston, where he worked for eight years in the Real
Estate Group. While at CS First Boston, Mr. Bigman established and managed the
REIT effort, including primary responsibility for $2.5 billion of initial public
offerings by real estate investment trusts. Previously, Mr. Bigman had extensive
real estate experience in a wide variety of transactions involving the financing
and sale of both individual assets and portfolios of real estate assets as well
as the acquisition and sale of several real estate companies. Mr. Bigman
graduated from Brandeis University in 1983 with a B.A. in Economics and received
his M.B.A. from Harvard University in 1987.
 
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the officers and the
Board of Directors of the Fund and include day-to-day administration of matters
related to the corporate existence of the Fund, maintenance of its records,
preparation of reports, supervision of the Fund's arrangements with its
custodian, and assistance in the preparation of the Fund's registration
statements under federal laws. The Administration Agreement also provides that
the Administrator, through its agents, will provide dividend disbursing and
transfer agent services to the Fund. For its services under the Administration
Agreement, the Fund pays the Adviser a monthly fee which on an annual basis
equals 0.15% of the average daily net assets of each Portfolio.
 
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors such administrative services provided by CGFSC.
Their services are also subject to the supervision of the Board of Directors of
the Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
                                       25
<PAGE>
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of each Portfolio upon the terms and at the current
offering price described in this Prospectus. Morgan Stanley is not obligated to
sell any certain number of shares of any Portfolio.
 
    The Portfolios currently offer only the classes of shares offered by this
Prospectus. The Portfolios may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares of each Portfolio pursuant to Rule 12b-1 under the 1940 Act (each, a
"Plan"). Under each Plan, the Distributor is entitled to receive from each
Portfolio a distribution fee, which is accrued daily and paid quarterly, of
0.25% of the Class B shares' average daily net assets on an annualized basis.
Each Plan is designed to compensate the Distributor for its services in
connection with distribution assistance. The Distributor may retain any portion
of the fee that it does not expend in meeting its obligations to the Fund. The
Distributor may compensate financial intermediaries, plan fiduciaries and
administrators for providing distribution-related services, including account
maintenance services, to shareholders (including, where applicable, underlying
beneficial owners) of Class B shares.
 
    EXPENSES.  Each Portfolio is responsible for payment of certain other fees
and expenses (including legal fees, accountant's fees, custodial fees, and
printing and mailing costs) as specified in its agreements with the Adviser and
Morgan Stanley.
 
    YEAR 2000.  The management and distribution services provided to the Fund by
the Adviser and Morgan Stanley depend on the smooth functioning of their
computer systems. Many computer software systems in use today cannot recognize
the year 2000, but revert to 1900 or some other date, due to the manner in which
dates were encoded and calculated. That failure could have a negative impact on
the handling of securities trades, pricing and account services. The Adviser and
Morgan Stanley have been actively working on necessary changes to their own
computer systems to deal with the year 2000 problem and expect that their
systems will be adapted before that date. There can be no assurance, however,
that they will be successful. In addition, other unaffiliated service providers
may be faced with similar problems. The Adviser and Morgan Stanley are
monitoring their remedial efforts, however, there can be no assurance that they
and the services they provide will not be adversely affected.
 
    In addition, it is possible that the markets for securities in which the
Portfolios invest may be detrimentally affected by computer failures throughout
the financial services industry beginning January 1, 2000. Improperly
functioning trading systems may result in settlement problems and liquidity
issues. In addition, corporate and governmental data processing errors may
result in production problems for individual companies and overall economic
uncertainties. Earnings of individual issuers will be affected by remediation
costs, which may be substantial and may be reported inconsistently in U.S. and
foreign financial statements. Accordingly, the Portfolios' investments may be
adversely affected.
 
                                       26
<PAGE>
                               PURCHASE OF SHARES
 
    Class A shares of each Portfolio and Class B shares of each Portfolio may be
purchased at the net asset value per share next determined after receipt by the
Fund of a purchase order as described under "Methods of Purchase." The net asset
value per share of each Portfolio is calculated on days that the New York Stock
Exchange ("NYSE") and Chase (the "Custodian Bank") are open for business as of
the close of trading of the NYSE, normally 4:00 p.m. Eastern Time (the "Pricing
Time").
 
MINIMUM INVESTMENT
 
    The minimum initial investment is $500,000 for Class A shares and $100,000
for Class B shares of each Portfolio. These minimums may be waived at the
discretion of the Adviser for certain types of investors, including trust
departments, brokers, dealers, agents, financial planners, financial services
firms, investment advisers or various retirement and deferred compensation plans
("Financial Intermediaries"), certain accounts managed by the Adviser and its
affiliates ("Managed Accounts"), and certain employees and customers of Morgan
Stanley and its affiliates. The Fund's determination of an investor's
eligibility to purchase shares of a given class will take precedence over the
investor's selection of a class.
 
METHODS OF PURCHASE
 
    Shares may be purchased directly from the Fund by Federal Funds wire, by
bank wire or by check. Investors may also invest in the Portfolios by purchasing
shares through Financial Intermediaries that have made arrangements with Morgan
Stanley. Some Financial Intermediaries may charge an additional service or
transaction fee. If a purchase is canceled due to nonpayment or because your
check does not clear, you will be responsible for any loss the Fund or its
agents incur. If you are already a shareholder, the Fund may redeem shares from
your account(s) to reimburse the Fund or its agents for any loss. In addition,
you may be prohibited or restricted from making future investments in the Fund.
 
    FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire Federal
Funds to the Fund's bank account. Federal Funds purchase orders will be accepted
only on a day on which the Fund and the Custodian Bank are open for business.
Your bank may charge a service fee for wiring Federal Funds. In order to ensure
proper handling of your purchase by Federal Funds wire, please follow these
steps:
 
    1.    Place your order by telephoning the Fund at 1-800-548-7786. A Fund
          representative will request certain purchase information and provide
          you with a confirmation number.
 
    2.    Instruct your bank to wire the specified amount to the Fund's Wire
          Concentration Bank Account as follows:
 
          The Chase Manhattan Bank
          One Manhattan Plaza
          New York, NY 10081-1000
          ABA# 021000021
          DDA# 910-2-733293
          Attn: Morgan Stanley Institutional Fund, Inc.
          Ref: (Portfolio name, your account number, your account name)
 
        Please call the Fund at 1-800-548-7786 prior to wiring the funds.
 
    3.    Complete and sign the Account Registration Form and mail it to the
          address shown thereon.
 
                                       27
<PAGE>
    When a purchase order is received prior to the Pricing Time and Federal
Funds are received prior to the close of the Federal Funds Wire Control Center
("FFWCC") (normally 6:00 p.m. Eastern Time), the purchase will be executed at
the net asset value computed on the date of receipt. Purchases for which an
order is received after the Pricing Time or for which Federal Funds are received
after the close of the FFWCC, will be executed at the net asset value next
determined. Certain institutional investors and financial institutions have
entered into an arrangement with Morgan Stanley, pursuant to which they may
place orders prior to the Pricing Time, but make payment in Federal Funds for
those shares on the following business day.
 
    BANK WIRE.  A purchase of shares by bank wire must follow the same procedure
as for a Federal Funds wire, described above. However, depending on the time the
bank wire is sent and which bank is handling the wire, money transferred by bank
wire may or may not be converted into Federal Funds prior to the close of the
FFWCC. Prior to conversion to Federal Funds and receipt by the Fund, an
investor's money will not be invested.
 
    CHECK.  An account may be opened by completing and signing an Account
Registration Form and mailing it, together with a check payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio name]" to:
 
    Morgan Stanley Institutional Fund, Inc.
    P.O. Box 2798
    Boston, Massachusetts 02208-2798
 
    The Fund ordinarily is credited with Federal Funds within one business day
of deposit of a check. Thus, a purchase of shares by check ordinarily will be
credited to your account at the net asset value per share of each of the
Portfolios determined on the next business day after receipt. An investor's
money will not be invested prior to crediting of Federal Funds.
 
    INVESTMENT THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to receive purchase and
redemption orders from underlying beneficial owners, such as retirement plan
participants, generally on each business day. Each business evening, the
Financial Intermediary aggregates all orders received from underlying beneficial
owners prior to the Pricing Time on that business day and places a net purchase
and/or redemption order(s) by the morning of the next business day. These orders
normally are executed at the net asset value that was computed for each
Portfolio as of the close of the previous business day.
 
    ADDITIONAL INVESTMENTS.  You may purchase additional shares for your account
at any time by purchasing shares at net asset value by any of the methods
described above. The minimum additional investment generally is $1,000 per
Portfolio. The minimum additional investment may be lower for certain accounts,
described above under "Minimum Investment." For purchases directly from the
Fund, your account name, the Portfolio name and the class selected must be
specified in the letter or wire to assure proper crediting to your account.
 
INVOLUNTARY CONVERSION AND REDEMPTION OF NEW ACCOUNT SHARES
 
    Class A and Class B shares of each Portfolio may be subject to the
involuntary conversion and redemption features described below. The conversion
and redemption features may be waived at the discretion of the Adviser for
shares held in a Managed Account and shares purchased through a Financial
Intermediary. Accounts
 
                                       28
<PAGE>
that were open prior to January 2, 1996 are not subject to involuntary
conversion or redemption. The Fund reserves the right to modify or terminate the
conversion or redemption features of the shares at any time upon 60 days notice
to shareholders.
 
    CONVERSION FROM CLASS A TO CLASS B SHARES.  If the value of an account
containing Class A shares falls below $500,000 (but remains at or above
$100,000) because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $500,000 (but remains at or
above $100,000) for a continuous 60-day period, the Class A shares in such
account will convert to Class B shares and will be subject to the distribution
fee and other features applicable to Class B shares. The Fund will not convert
Class A shares to Class B shares based solely upon changes in the market that
reduce the net asset value of shares. Under current tax law, conversion between
share classes is not a taxable event to the shareholder.
 
    CONVERSION FROM CLASS B TO CLASS A SHARES.  If the value of an account
containing Class B shares increases to $500,000 or more, whether due to
shareholder purchases or market activity, the Class B shares will convert to
Class A shares. Class B shares purchased through a Financial Intermediary that
has entered into an arrangement with the Fund for the purchase of such shares
may not be converted. Under current tax law, such conversion is not a taxable
event to the shareholder. Class A shares converted from Class B shares are
subject to the same minimum account size requirements as are applicable to New
Accounts containing Class A shares described above.
 
    INVOLUNTARY REDEMPTION OF SHARES.  If the value of an account falls below
$100,000 because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $100,000 for a continuous
60-day period, the shares in such account will be subject to redemption by the
Fund. The Fund will not redeem shares based solely upon changes in the market
that reduce the net asset value of shares. If redeemed, redemption proceeds will
be promptly paid to the shareholder.
 
                              REDEMPTION OF SHARES
 
    Class A and Class B shares of each Portfolio may be redeemed at any time and
without charge at the net asset value per share next determined after receipt by
the Fund of a redemption order as described under "Methods of Redemption."
Redemption proceeds may be more or less than the purchase price of your shares
depending on, among other factors, the market value of the investment securities
held by a Portfolio.
 
METHODS OF REDEMPTION
 
    Shares may be redeemed directly from the Fund by mail or by telephone.
However, shares purchased through a Financial Intermediary must be redeemed
through a Financial Intermediary. Certain Financial Intermediaries may charge an
additional service or transaction fee.
 
    BY MAIL.  Each Portfolio will redeem shares upon receipt of a redemption
request in "good order." Redemption requests may be sent by regular mail to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798 or, by overnight courier, to Morgan Stanley Institutional Fund, Inc.,
c/o Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913.
 
    "Good order" means that the request to redeem shares must include the
following:
 
    1. A letter of instruction or a stock assignment specifying the class and
number of shares or dollar amount to be redeemed, signed by all registered
owners of the shares in the exact names in which they are registered;
 
                                       29
<PAGE>
    2. Any required signature guarantees; and
 
    3. Other supporting legal documents, if required, in the case of estates,
trusts, guardianships, custodianships, corporations, pension and profit-sharing
plans and other organizations.
 
    Redemption requests received in "good order" prior to the Pricing Time will
be executed at the net asset value computed on the date of receipt. Redemption
requests received after the Pricing Time will be executed at the next determined
net asset value. Shareholders who are uncertain of requirements for redemption
by mail should consult with a Fund representative.
 
    BY TELEPHONE.  If you have previously elected the Telephone Redemption
Option on the Account Registration Form, you can redeem Portfolio shares by
calling the Fund and requesting that the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. To change the commercial bank or account designated to receive
redemption proceeds, send a written request to the Fund at the address above.
Requests to change the bank or account must be signed by each shareholder and
each signature must be guaranteed. The telephone redemption option may be
difficult to implement at times, particularly during volatile market conditions.
If you experience difficulty in making a telephone redemption, you may redeem
shares by mail as described above.
 
    The Fund and the Transfer Agent will employ reasonable procedures to confirm
that instructions communicated by telephone are genuine. An investor may be
required to provide personal identification information at the time an account
is opened and prior to effecting each telephone transaction. In addition, all
telephone transaction requests will be recorded and investors may be required to
provide additional telecopied written instructions regarding transaction
requests. Neither the Fund nor the Transfer Agent will be responsible for any
loss, liability, cost or expense for following instructions received by
telephone that either of them reasonably believes to be genuine.
 
    REDEMPTION THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to accept redemption
requests from underlying beneficial owners. These redemptions may be processed
in the same way as purchases made through such Financial Intermediaries, as
described above.
 
FURTHER REDEMPTION INFORMATION
 
    The Fund normally makes payment for all shares redeemed within one business
day of receipt of the request, and in no event more than seven days after
receipt of a redemption request in good order. However, payments to investors
redeeming shares which were purchased by check will not be made until payment
for the purchase has been collected, which may take up to eight days after the
date of purchase. The Fund may suspend the right of redemption or postpone the
date upon which redemptions are effected at times when the NYSE is closed, or
under any emergency conditions as determined by the Securities and Exchange
Commission (the "Commission").
 
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of a Portfolio to make payment in
cash, the Fund may pay redemption proceeds in whole or in part by a
distribution-in-kind of readily marketable portfolio securities in accordance
with applicable rules of the Commission. Shareholders may incur brokerage
charges on the sale of portfolio securities received in payment of redemptions.
 
                                       30
<PAGE>
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required to verify the identity of the person who has authorized
certain redemptions. Please contact the Fund or see the Statement of Additional
Information for further information.
 
                         ACCOUNT POLICIES AND SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares of each Portfolio that you own for shares of any
other available portfolio(s) of the Fund, subject to certain limitations. You
cannot exchange for shares of the International Equity, Emerging Markets, Small
Cap Value Equity, Balanced or Gold Portfolios because they are currently closed
to new investors. In addition, certain portfolios may be unavailable to
shareholders who purchased portfolio shares through a Financial Intermediary.
Contact your Financial Intermediary to determine which portfolios are available
for exchange.
 
    Before you make an exchange, you should read the prospectus of the
portfolio(s) in which you seek to invest. The class of shares you receive in the
exchange will be determined in the same manner as any other purchase of shares,
including minimum initial investment and account size requirements, and will not
be based on the class of shares you surrender for the exchange. Exchange
transactions are treated as a redemption followed by a purchase. Therefore, an
exchange will be considered a taxable event for shareholders subject to tax.
Exchange transactions will be processed at the net asset value per share next
determined after receipt of the request. Shares of the portfolios may be
exchanged by mail or telephone. The telephone exchange privilege is automatic
and made available without shareholder election. The exchange privilege may be
modified or terminated by the Fund at any time upon 60-days notice to
shareholders.
 
    BY MAIL.  To exchange shares by mail, send a written exchange request to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798. Your written exchange request should include (i) the name, class of
shares and account number of your current Portfolio; (ii) the name(s) and
class(es) of shares of the portfolio(s) into which you intend to exchange
shares; and (iii) the signatures of all registered account holders.
 
    BY TELEPHONE.  To exchange shares by telephone, call the Fund at the phone
number provided on the cover of this Prospectus. A Fund representative will
request (i) the name, class of shares and account number of your current
Portfolio, and (ii) the name(s) and class(es) of shares of the portfolio(s) into
which you intend to exchange shares. For additional information regarding
responsibility for the authenticity of telephoned instructions, see "Redemption
of Shares" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by sending a written request to Morgan Stanley Institutional Fund, Inc.,
P.O. Box 2798, Boston, Massachusetts 02208-2798. It may not be possible to
transfer the registration of certain shares purchased through a Financial
Intermediary. As with redemptions, the written request must be received in "good
order" before any transfer can be made. Transferring the registration of shares
may affect the eligibility of your account for a given class of shares and may
result in involuntary conversion or redemption of your shares.
 
                                       31
<PAGE>
OTHER ACCOUNT INFORMATION
 
    The Fund does not issue share certificates for the Portfolios. All shares
purchased are confirmed to you and credited to your account on the Fund's books
maintained by the Adviser or its agents. You will have the same rights and
ownership with respect to such shares as if certificates had been issued.
 
EXCESSIVE TRADING
 
    Frequent trades in your account(s) can disrupt management of a Portfolio and
raise its expenses. Consequently, the Fund may, in its discretion and in the
interest of each Portfolio's shareholders and performance, bar a shareholder who
trades excessively from making further share purchases for an indefinite period.
The Fund considers excessive trading to be more than one purchase and sale
involving shares of the same class of a portfolio of the Fund within any 120-day
period. For example, the following series of transactions would amount to
excessive trading: exchanging shares of Portfolio A for shares of Portfolio B,
then exchanging shares of Portfolio B for shares of Portfolio C and then
exchanging shares of Portfolio C for shares of Portfolio A within a 120-day
period. Two types of transactions are exempt from these excessive trading
restrictions: (i) trades exclusively between money market portfolios, and (ii)
trades made in connection with an asset allocation service managed or advised by
the Adviser and/or any of its affiliates.
 
INVESTMENT IN PORTFOLIOS BY OTHER INVESTMENT ACCOUNTS
 
    Morgan Stanley or its affiliates, including Morgan Stanley Asset Management
Inc., manage investment accounts for other clients, including other investment
companies, that invest in Class A or Class B shares of the portfolios. From time
to time, one or more of the Portfolios used for investment by these accounts may
experience relatively large investments or redemptions due to investment
decisions made on behalf of these accounts. These transactions will affect the
portfolios, since portfolios that experience significant redemptions may have to
sell portfolio securities and portfolios that receive additional cash will have
to invest it in additional portfolio securities. It is impossible to predict the
overall impact of these transactions over time, however, there could be adverse
effects on portfolio management. These transactions also could have tax
consequences if sales of portfolio securities result in gains or could increase
transaction costs. The Adviser, representing the interests of the portfolios, is
committed to minimizing the impact of these transactions to the portfolios. The
Adviser, however, will have a conflict in fulfilling this responsibility in that
it also advises these investment accounts. The Adviser will monitor the impact
of these transactions on the Portfolios.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of each of the Portfolios
is determined by dividing the total market value of the Portfolio's investments
and other assets attributable to such class, less any liabilities attributable
to such class, by the total number of outstanding shares of each class of the
Portfolio. Net asset value is calculated separately for each class of the
Portfolios. Net asset value per share is determined as of the close of the NYSE
(normally 4:00 p.m. Eastern Time) on each day that the NYSE is open for
business. Price information on listed securities is taken from the exchange
where the security is primarily traded. Securities listed on a U.S. securities
exchange for which market quotations are available are valued at the last quoted
sale price on the day the valuation is made. Securities listed on a foreign
exchange are valued at their closing price. Unlisted securities and listed
securities not traded on the valuation date and for which market quotations are
not readily
 
                                       32
<PAGE>
available are valued at a price within a range not exceeding the current asked
price nor less than the current bid price. The current bid and asked prices are
determined based on the average of the bid and asked prices quoted on such
valuation date by reputable brokers.
 
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily. In addition, bonds and other fixed income securities may be
valued on the basis of prices provided by a pricing service when such prices are
believed to reflect the fair market value of such securities. The prices
provided by a pricing service are determined without regard to bid or last sale
prices but take into account institutional-size trading in similar groups of
securities and any developments related to the specific securities. Securities
not priced in this manner are valued at the most recently quoted bid price or,
when securities exchange valuations are used, at the latest quoted sale price on
the day of valuation. If there is no such reported sale, the latest quoted bid
price will be used. Securities purchased with remaining maturities of 60 days or
less are valued at amortized cost, if it approximates market value. In the event
that amortized cost does not approximate market value, market prices as
determined above will be used.
 
    The value of other assets and securities for which quotations are not
readily available (including restricted and unlisted foreign securities) and
those securities for which it is inappropriate to determine the prices in
accordance with the above-stated procedures are determined in good faith at fair
value using methods determined by the Board of Directors. For purposes of
calculating net asset value per share, all assets and liabilities initially
expressed in foreign currencies will be translated into U.S. dollars at the mean
of the bid and asked price for such currencies against the U.S. dollar last
quoted by a major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distribution expense accrual differential among the classes. The
net asset value of Class B shares will generally be lower than the net asset
value of the Class A shares as a result of the distribution expense charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise total return for each class of a
Portfolio. THESE FIGURES ARE BASED ON HISTORICAL EARNINGS AND ARE NOT INTENDED
TO INDICATE FUTURE PERFORMANCE.
 
    Each of the Portfolios may advertise "total return" which shows what an
investment in a class of a Portfolio would have earned over a specified period
of time (such as one, five or ten years), assuming that all distributions and
dividends by the Portfolio were reinvested in the same class on the reinvestment
dates during the period. Total return does not take into account any federal or
state income taxes that may be payable on dividends and distributions or on
redemption. The Fund may also include comparative performance information in
advertising or marketing the Portfolios' shares, including data from Lipper
Analytical Services, Inc., other industry publications, business periodicals,
rating services and market indices.
 
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                                       33
<PAGE>
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains distributions for a class of shares
will be automatically reinvested in additional shares at net asset value, except
when, upon written notice to the Fund or by checking off the appropriate box in
the Distribution Option Section on the Account Registration Form, a shareholder
elects to receive income dividends and capital gains distributions in cash.
 
    Each Portfolio expects to distribute substantially all of its taxable net
investment income in the form of quarterly dividends. Net realized capital
gains, if any, after reduction for any available tax loss carryforwards will
also be distributed annually.
 
    Undistributed net investment income is included in a Portfolio's net assets
for the purpose of calculating net asset value per share. Therefore, on the
"ex-dividend" date, the net asset value per share excludes the dividend (i.e.,
is reduced by the per share amount of the dividend). Dividends paid shortly
after the purchase of shares by an investor, although in effect a return of
capital, are taxable to shareholders subject to income tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of the Portfolios will differ at times.
Expenses of the Portfolios allocated to a particular class of shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of the Portfolios or their shareholders.
Accordingly, shareholders are urged to consult their tax advisers regarding
specific questions as to federal, state and local income taxes.
 
    Each Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other portfolios. Each Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Code, so that the Portfolio will be relieved
of federal income tax on that part of its net investment income and net capital
gain that is distributed to shareholders.
 
    Each Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, the excess of net short-term
capital gain over net long-term capital loss) to shareholders. Dividends from a
Portfolio's net investment income are taxable to shareholders as ordinary
income, whether received in cash or in additional shares. Such dividends paid by
a Portfolio will generally qualify for the corporate dividends received
deduction only to the extent of the aggregate qualifying dividend income
received by the Portfolio from U.S. corporations. Each Portfolio will report
annually to its shareholders the amount of dividend income qualifying for the
corporate dividend received deduction.
 
    Distributions of net capital gain are taxable to shareholders as a 20% rate
gain distribution (taxed at a rate of 20%) or a 28% rate gain distribution
(taxed at a rate of 28%), depending upon the designation by the Portfolio
 
                                       34
<PAGE>
(such designation being dependent upon the holding period of the Portfolio in
the underlying asset generating the net capital gain), regardless of how long
shareholders have held their shares. Each Portfolio will send reports annually
to its shareholders of the federal income tax status of all distributions made
during the preceding year.
 
    Each Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gain over short-term and long-term capital
loss) prior to the end of each calendar year to avoid liability for federal
excise tax.
 
    Dividends and other distributions declared by a Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders in that year if the distributions are paid by the Portfolio at
any time during the following January.
 
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any dividends, capital gains distributions and redemption proceeds paid to any
individual or certain other non-corporate shareholder (i) who has failed to
provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Account Registration Form; (ii) who is subject to backup withholding by the
Internal Revenue Service; or (iii) who has not certified to the Fund that such
shareholder is not subject to backup withholding. This backup withholding is not
an additional tax, and any amounts withheld may be credited against the
shareholder's ultimate U.S. tax liability.
 
    The sale, redemption or exchange of shares will result in taxable gain or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the sale, exchange or redemption proceeds exceeds or is
less than the shareholder's adjusted tax basis in the redeemed, exchanged or
sold shares. Any such taxable gain or loss generally will be treated as
long-term capital gain or loss if the shares have been held for more than one
year and otherwise generally will be treated as short-term capital gain or loss.
If capital gains distributions have been made with respect to shares that are
sold at a loss after being held for six months or less, however, the loss is
treated as a long-term capital loss to the extent of the capital gains
distributions.
 
    Conversions of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisers concerning the
application of state and local income taxes to investments in a Portfolio, which
may differ from the federal income tax consequences described above.
 
    Investment income received by a Portfolio from sources within foreign
countries may be subject to foreign income taxes withheld at the source. To the
extent that the Asian Real Estate Portfolio or the European Real Estate
Portfolio is liable for foreign income taxes so withheld, such Portfolio intends
to operate so as to meet the requirements of the Code to pass through to its
shareholders credit, if any, for foreign income taxes paid. Although each of the
Asian Real Estate and European Real Estate Portfolios intends to meet Code
requirements to pass through credit for such taxes, there can be no assurance
that it will be able to do so.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN A PORTFOLIO.
 
                                       35
<PAGE>
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolios
for their clients.
 
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other remuneration paid to Morgan Stanley or other affiliates must be
fair and reasonable in comparison to those of other broker-dealers for
comparable transactions involving similar securities being purchased or sold
during a comparable time period.
 
PORTFOLIO TURNOVER
 
    The Portfolios generally do not invest for short-term trading purposes,
however, when circumstances warrant, each Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolios will not consider portfolio turnover rate
a limiting factor in making investment decisions consistent with its respective
objective and policies. For the fiscal year ended December 31, 1997, the U.S.
Real Estate Portfolio had a portfolio turnover rate of 135%. Higher portfolio
turnover (e.g., over 100%) necessarily will cause the Portfolios to pay
correspondingly increased brokerage and trading costs. In addition to
transaction costs, higher portfolio turnover may result in the realization of
capital gains. As discussed under "Taxes," to the extent net short-term capital
gains are realized, any distributions resulting from such gains are considered
ordinary income for federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 40 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of each
Portfolio are currently classified into two classes, the Class A shares and the
Class B shares.
 
    The shares of each Portfolio, when issued, will be fully paid,
nonassessable, fully transferable and redeemable at the option of the holder.
The shares have no preference as to conversion, exchange, dividends, retirement
 
                                       36
<PAGE>
or other features and have no pre-emptive rights. The shares of each Portfolio
have non-cumulative voting rights, which means that the holders of more than 50%
of the shares voting for the election of Directors can elect 100% of the
Directors if they choose to do so. Persons or organizations owning 25% or more
of the outstanding shares of the Portfolio may be presumed to "control" (as
defined in the 1940 Act) such Portfolio. Under Maryland law, the Fund is not
required to hold an annual meeting of its shareholders unless required to do so
under the 1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual and semi-annual reports. The
financial statements appearing in annual reports are audited by independent
accountants. Monthly unaudited portfolio data is also available from the Fund
upon request.
 
    In addition, the Adviser, or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
CUSTODIAN
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs subcustodians approved by the Board of Directors of the Fund
in accordance with regulations of the Securities and Exchange Commission for the
purpose of providing custodial services for such assets. MSTC may also hold
certain domestic assets for the Fund. For more information on the custodians,
see "General Information -- Custody Arrangements" in the Statement of Additional
Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits the annual financial statements of each Portfolio.
 
FUND COUNSEL
 
    Morgan, Lewis & Bockius LLP acts as the Fund's legal counsel.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       37
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
          EUROPEAN REAL ESTATE, ASIAN REAL ESTATE AND U.S. REAL ESTATE
PORTFOLIOS
           P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                                 <C>
                                                          If you need assistance in filling out this
                                                          form for the Morgan Stanley Institutional
      ACCOUNT INFORMATION                                 Fund, Inc., please contact your Morgan
      Fill in where applicable                            Stanley representative or call us toll free
                                                          1-800-548-7786. Please print all items except
                                                          signature, and mail to the Fund at the
                                                          address above.
 
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
        (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
        TENANCY IN COMMON
        IS INDICATED)
</TABLE>
 
1.
                               First
Name                          Initial                               Last Name
 
2.
                               First
Name                          Initial                               Last Name
 
                               First
Name                          Initial                               Last Name
 
<TABLE>
<S>   <C>
<FN>
 
3.    CORPORATIONS,
      TRUSTS AND OTHERS
      Please call the Fund for additional documents that may be required to set
      up account and to authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                   <C>               <C>                  <C>              <C>
Type of               / / INCORPORATED  / / UNINCORPORATED   / / PARTNERSHIP  / / UNIFORM GIFT/TRANSFER TO MINOR
Registration:                           ASSOCIATION                             (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
 
<TABLE>
<C>   <S>                                            <C>
  B)  MAILING ADDRESS
      Please fill in completely, including
      telephone number(s).
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
 
/ / Non-Resident Alien
 
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
 
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
 
<TABLE>
<C>   <S>                                       <C>                                       <C>
  C)  TAXPAYER                                  Enter your Taxpayer Identification Number. For most individual taxpayers, this is
      IDENTIFICATION                            your Social Security Number.
      NUMBER
      1. INDIVIDUAL
      2. JOINT TENANTS
        (RIGHTS OF SURVIVORSHIP PRESUMED
      UNLESS
        TENANCY IN COMMON
        IS INDICATED)
      For Custodian account
      of a minor (Uniform
      Gifts/Transfers to Minor
      Acts), give the Social
      Security Number of
      the minor.
                                                1.           TAXPAYER IDENTIFICATION      OR               SOCIAL SECURITY NUMBER
                                                NUMBER ("TIN")                            ("SSN")
                                                2. TIN                                    OR SSN
                                                TIN                                       OR SSN
</TABLE>
<PAGE>
<TABLE>
<C>   <S>                                       <C>                                       <C>
                                                IMPORTANT TAX INFORMATION
                                                You (as a payee) are required by law to provide us (as payer) with your correct
                                                TIN(s) or SSN(s). Accounts that have a missing or incorrect TIN(s) or SSN(s) will
                                                be subject to backup withholding at a 31% rate on dividends, distributions and
                                                other payments. If you have not provided us with your correct TIN(s) or SSN(s),
                                                you may be subject to a $50 penalty imposed by the Internal Revenue Service.
                                                Backup withholding is not an additional tax; the tax liability of persons subject
                                                to backup withholding will be reduced by the amount of tax withheld. If
                                                withholding results in an overpayment of taxes, a refund may be obtained.
                                                You may be notified that you are subject to backup withholding under Section
                                                3406(a)(1)(C) of the Internal Revenue Code because you have underreported interest
                                                or dividends or you were required to, but failed to, file a return which would
                                                have included a reportable interest or dividend payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                       <C>                             <C>                   <C>
  D)  PORTFOLIO AND                             For Purchase of the following
      CLASS SECTION                             Portfolio:                      / / Class A Shares $  / / Class B Shares $
      (Class A shares minimum $500,000 for      European Real Estate Portfolio  / / Class A Shares $  / / Class B Shares $
      each Portfolio and Class B shares         Asian Real Estate Portfolio     / / Class A Shares $  / / Class B Shares $
      minimum $100,000 for each Portfolio).     U.S. Real Estate Portfolio
      Please indicate name of Portfolio, class
      and amount.
                                                                                Total Initial Investment $
</TABLE>
 
<TABLE>
<C>   <S>                                       <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate portfolio and manner of
      payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                                 <C>
/ / Exchange $ From                                                                           -- - - - - - - - - - -- - -
                                                      Name of Portfolio             Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on                       - - - - - - - - - - - -- - -
                                                                                            Account No.               (Check
                                                                                      (Previously assigned by the Fund)     Digit)
                                                                            Date
</TABLE>
 
<TABLE>
<C>   <S>                                       <C>
  F)  DISTRIBUTION                              Income dividends and capital gains distributions (if any) to
      OPTION                                    be reinvested in additional shares unless either box below
                                                is checked.
                                                / / Income dividends to be paid in cash, capital gains
                                                distributions (if any) in shares.
                                                / / Income dividends and capital gains distributions (if
                                                any) to be paid in cash.
</TABLE>
<TABLE>
<C>   <S>                             <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone
      AND EXCHANGE                    requests to wire redemption proceeds to
      OPTION                          the commercial bank indicated at right
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund
      wish to redeem or exchange      account is registered if such requests
      shares by telephone. A          are believed to be authentic.
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated
      YOUR FUND ACCOUNT.              by telephone are genuine. These
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal
      NOT BE HONORED UNLESS THE BOX   identification information at the time
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
 
<CAPTION>
  G)
      Name of COMMERCIAL Bank (Not Savings Bank)
      Bank Account No.
                                                   Bank ABA No.
      Name(s) in which your Bank Account is Established
      Bank's Street Address
      City                           State                           Zip
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  H)  INTERESTED PARTY
      OPTION                                                                                      Name
      In addition to the
      account statement sent to
      my/our registered                                                                          Address
      address, I/we hereby
      authorize the Fund to      City         State         Zip Code
      mail duplicate statements
      to the name and address
      provided at right.
</TABLE>
 
<TABLE>
<C>   <S>                                       <C>
  I)  DEALER
      INFORMATION
                                                Representative Name                        Representative
                                                No.                            Branch
                                                No.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                       <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here ,
</TABLE>
 
<TABLE>
<S>                                                           <C>
The undersigned certify that I/we have full authority and legal capacity to purchase and redeem shares of the Fund and
affirm that I/we have received a current Prospectus of the Morgan Stanley Institutional Fund, Inc. and agree to be bound
by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF PERJURY THAT THE INFORMATION ON THIS APPLICATION IS
COMPLETE AND CORRECT AND THAT AS REQUIRED BY FEDERAL LAW (PLEASE CHECK APPLICABLE BOXES BELOW):
/ / U.S. CITIZEN(S)/TAXPAYER(S):
       / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM IS/ARE THE CORRECT SSN(S) OR TIN(S) AND (2) I/WE
           ARE NOT SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE ARE EXEMPT FROM BACKUP WITHHOLDING; (B) I/WE
           HAVE NOT BEEN NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT I/WE ARE SUBJECT TO BACKUP WITHHOLDING AS A
           RESULT OF A FAILURE TO REPORT ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED ME/US THAT I AM/WE ARE NO
           LONGER SUBJECT TO BACKUP WITHHOLDING.
       / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE HAVE APPLIED, OR INTEND TO APPLY, TO THE IRS OR THE
           SOCIAL SECURITY ADMINISTRATION FOR A TIN OR A SSN AND I/WE UNDERSTAND THAT IF I/WE DO NOT PROVIDE EITHER NUMBER
           TO CHASE GLOBAL FUNDS SERVICES COMPANY ("CGFSC") WITHIN 60 DAYS OF THE DATE OF THIS APPLICATION OR IF I/WE FAIL
           TO FURNISH MY/OUR CORRECT SSN(S) OR TIN(S), I/WE MAY BE SUBJECT TO A PENALTY AND A 31% BACKUP WITHHOLDING ON
           DISTRIBUTIONS AND REDEMPTION PROCEEDS. (PLEASE PROVIDE EITHER NUMBER ON IRS FORM W-9). YOU MAY REQUEST SUCH
           FORM BY CALLING CGFSC AT 800-282-4404.
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
  UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S. CITIZENS OR RESIDENTS AND I/WE ARE EXEMPT FOREIGN
PERSONS AS DEFINED BY THE INTERNAL REVENUE SERVICE.
 
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY PROVISION OF THIS DOCUMENT OTHER THAN THE CERTIFICATIONS
REQUIRED TO AVOID BACKUP WITHHOLDING.
 
(X)                                                           (X)
Signature                                            Date     Signature (if joint account, both must sign)   Date
</TABLE>
<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<S>                                                                         <C>
                                                                            PAGE
                                                                            ----
Fund Expenses.............................................................    2
Financial Highlights......................................................    4
Prospectus Summary........................................................    8
Investment Objectives and Policies........................................   12
Additional Investment Information.........................................   13
Investment Limitations....................................................   23
Management of the Fund....................................................   23
Purchase of Shares........................................................   27
Redemption of Shares......................................................   29
Account Policies and Services.............................................   31
Valuation of Shares.......................................................   32
Performance Information...................................................   33
Dividends and Capital Gains Distributions.................................   34
Taxes.....................................................................   34
Portfolio Transactions....................................................   36
General Information.......................................................   36
Account Registration Form
</TABLE>
 
                         EUROPEAN REAL ESTATE PORTFOLIO
                          ASIAN REAL ESTATE PORTFOLIO
                           U.S. REAL ESTATE PORTFOLIO
                               PORTFOLIOS OF THE
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
 
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  Incorporated
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
                      P.O. BOX 2798, BOSTON, MA 02208-2798
<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
     ----------------------------------------------------------------------
 
                         INTERNATIONAL MAGNUM PORTFOLIO
 
                               A PORTFOLIO OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
 
                                ----------------
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a series of diversified and non-diversified investment portfolios
("portfolios"). The Fund is designed to provide clients with attractive
alternatives for meeting their investment needs. The Fund currently consists of
thirty-two portfolios representing a broad range of investment choices. This
prospectus (the "Prospectus") pertains to the Class A and Class B shares of the
International Magnum Portfolio (the "Portfolio"). The Class A and Class B shares
currently offered by the Portfolio have different minimum investment
requirements and fund expenses. Shares of the Portfolio are offered with no
sales charge, exchange fee or redemption fee.
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator"), and with Morgan Stanley & Co. Incorporated ("Morgan Stanley")
as Distributor, the Fund makes available to institutional and high net worth
individual investors a series of portfolios which benefit from the investment
expertise and commitment to excellence associated with Morgan Stanley and its
affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under "Prospectus Summary" below. The Fund
currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging Markets,
European Equity, European Real Estate, Global Equity, International Equity,
International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) EQUITY AND FIXED INCOME -- Balanced
Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global
Fixed Income, High Yield and Municipal Bond Portfolios; and (v) MONEY MARKET --
Money Market and Municipal Money Market Portfolios. Additional information about
the Fund is contained in a "Statement of Additional Information," dated May 1,
1998, which is incorporated herein by reference. The Statement of Additional
Information and the prospectuses pertaining to the other portfolios of the Fund
are available upon request and without charge by writing or calling the Fund at
the address and telephone number set forth above.
 
  THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
   AND EXCHANGE COMMISSION NOR HAS THE SECURITIES AND EXCHANGE COMMISSION
    PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS.     ANY
             REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
                  THE DATE OF THIS PROSPECTUS IS MAY 1, 1998.
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates all expenses and fees that a shareholder of
the International Magnum Portfolio will incur:
<TABLE>
<CAPTION>
SHAREHOLDER TRANSACTION EXPENSES
- ------------------------------------------------------------------------------------------
<S>                                                                                         <C>
Maximum Sales Load Imposed on Purchases
  Class A.................................................................................        None
  Class B.................................................................................        None
Maximum Sales Load Imposed on Reinvested Dividends
  Class A.................................................................................        None
  Class B.................................................................................        None
Deferred Sales Load
  Class A.................................................................................        None
  Class B.................................................................................        None
Redemption Fees
  Class A.................................................................................        None
  Class B.................................................................................        None
Exchange Fees
  Class A.................................................................................        None
  Class B.................................................................................        None
 
<CAPTION>
 
ANNUAL FUND OPERATING EXPENSES
  (AS A PERCENTAGE OF AVERAGE NET ASSETS)
- ------------------------------------------------------------------------------------------
<S>                                                                                         <C>
Management Fee (Net of Fee Waiver)*
  Class A.................................................................................       0.61%
  Class B.................................................................................       0.61%
12b-1 Fees
  Class A.................................................................................        None
  Class B.................................................................................       0.25%
Other Expenses
  Class A.................................................................................       0.39%
  Class B.................................................................................       0.39%
                                                                                            -----------
Total Operating Expenses (Net of Fee Waivers)*
  Class A.................................................................................       1.00%
  Class B.................................................................................       1.25%
                                                                                            -----------
                                                                                            -----------
</TABLE>
 
- ------------------------
* The Adviser has agreed to waive its management fees and/or to reimburse the
  Portfolio, if necessary, if such fees would cause the total annual operating
  expenses of the Portfolio to exceed a specified percentage of its average
  daily net assets. Absent the fee waiver, the management fee would be 0.80%.
  Absent the fee waiver and/or expense reimbursement, the Portfolio's total
  operating expenses would be 1.19% of the average daily net assets of the Class
  A shares and 1.44% of the average daily net assets of the Class B shares. As a
  result of this reduction, the Management Fee stated above is lower than the
  contractual fee stated under "Management of the Fund." The Adviser reserves
  the right to terminate any of its fee waivers and/or expense reimbursements at
  any time in its sole discretion. For further information on Fund expenses, see
  "Management of the Fund."
 
                                       2
<PAGE>
    The purpose of the table above is to assist the investor in understanding
the various expenses that an investor in the Portfolio will bear directly or
indirectly. Expenses and fees are based on actual figures for the fiscal year
ended December 31, 1997. Due to the continuous nature of Rule 12b-1 fees,
long-term Class B shareholders may pay more than the equivalent of the maximum
front-end sales charges otherwise permitted by the National Association of
Securities Dealers, Inc. ("NASD") Conduct Rules.
 
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (i) a 5% annual rate of return, and (ii) redemption
at the end of each time period. As noted in the table above, the Portfolio
charges no redemption fees of any kind. The following example is based on the
total operating expenses of the Portfolio after fee waivers.
 
<TABLE>
<CAPTION>
                                                                       1 YEAR       3 YEARS      5 YEARS     10 YEARS
                                                                     -----------  -----------  -----------  -----------
<S>                                                                  <C>          <C>          <C>          <C>
International Magnum Portfolio
  Class A..........................................................   $      10    $      32    $      55    $     122
  Class B..........................................................          13           40           69          151
</TABLE>
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. ACTUAL EXPENSES MAY BE GREATER OR LESS THAN THOSE
SHOWN.
 
                                       3
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following table provides financial highlights for the Class A and Class
B shares of the International Magnum Portfolio for each of the periods
presented. The audited financial highlights for the Portfolio's shares for each
of the periods presented are part of the Fund's financial statements which
appear in the Fund's December 31, 1997 Annual Report to Shareholders and which
are incorporated by reference into the Fund's Statement of Additional
Information. The Portfolio's financial highlights for each of the periods
presented have been audited by Price Waterhouse LLP, whose unqualified report
thereon is also incorporated by reference into the Statement of Additional
Information. Additional performance information is included in the Annual
Report. The Annual Report and the financial statements therein, along with the
Statement of Additional Information, are available at no cost from the Fund at
the address and telephone number noted on the cover page of this Prospectus. The
following information should be read in conjunction with the financial
statements and notes thereto.
 
                                       4
<PAGE>
                         INTERNATIONAL MAGNUM PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                CLASS A                           CLASS B
                                                    --------------------------------  --------------------------------
                                                                       PERIOD FROM                       PERIOD FROM
                                                      YEAR ENDED     MARCH 15, 1996*    YEAR ENDED     MARCH 15, 1996*
                                                     DECEMBER 31,    TO DECEMBER 31,   DECEMBER 31,    TO DECEMBER 31,
                                                         1997             1996             1997             1996
                                                    ---------------  ---------------  ---------------  ---------------
<S>                                                 <C>              <C>              <C>              <C>
NET ASSET VALUE, BEGINNING OF PERIOD..............    $     10.66       $   10.00        $   10.63        $   10.00
                                                    ---------------       -------          -------          -------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1).......................           0.17            0.06             0.16             0.01
  Net Realized and Unrealized Gain on
   Investments....................................           0.54            0.76             0.52             0.78
                                                    ---------------       -------          -------          -------
    Total from Investment Operations..............           0.71            0.82             0.68             0.79
                                                    ---------------       -------          -------          -------
DISTRIBUTIONS
  Net Investment Income...........................          (0.41)          (0.13)           (0.38)           (0.13)
  In Excess of Net Investment Income..............             --           (0.02)              --            (0.02)
  Net Realized Gain...............................          (0.09)          (0.01)           (0.09)           (0.01)
                                                    ---------------       -------          -------          -------
    Total Distributions...........................          (0.50)          (0.16)           (0.47)           (0.16)
                                                    ---------------       -------          -------          -------
NET ASSET VALUE, END OF PERIOD....................    $     10.87       $   10.66        $   10.84        $   10.63
                                                    ---------------       -------          -------          -------
                                                    ---------------       -------          -------          -------
TOTAL RETURN......................................           6.58%           8.25%            6.33%            7.90%
                                                    ---------------       -------          -------          -------
                                                    ---------------       -------          -------          -------
RATIOS AND SUPPLEMENTAL DATA:.....................
  Net Assets, End of Period (Thousands)...........    $   159,096       $  85,316        $  28,217        $  23,173
  Ratio of Expenses to Average Net Assets (1).....           1.00%           1.00%**          1.25%            1.25%**
  Ratio of Net Investment Income to Average Net
   Assets (1).....................................           1.44%           0.99%**          1.19%            0.60%**
  Portfolio Turnover Rate.........................             41%             18%              41%              18%
  Average Commission Rate Per Share#..............        $0.0198         $0.0211           $0.0198          $0.0211
</TABLE>
 
- ------------------------
 
<TABLE>
<C>  <S>                                              <C>              <C>              <C>              <C>
Average Commission Rate as a Percentage of Trade
 Amount.............................................          0.27   %         0.25   %         0.27   %         0.25   %
(1)  Effect of voluntary expense limitation during
      the period:
       Per share benefit to net investment income...         $0.02            $0.03            $0.02            $0.01
     Ratios before expense limitation:
       Expenses to Average Net Assets...............          1.19   %         1.54   %**         1.44   %         1.69   %**
       Net Investment Income to Average Net
        Assets......................................          1.25   %         0.44   %**         1.00   %         0.15   %**
</TABLE>
 
- --------------------------------------------------------------------------------
 * Commencement of operations
 ** Annualized
 
                                       5
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and high net worth individual investors a broad range of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates providing customized services as Adviser, Administrator and
Distributor. Each portfolio offers Class A and Class B shares, except for the
International Small Cap and Municipal Money Market Portfolios, which offer only
Class B shares. Each portfolio has its own investment objective and policies
designed to meet its specific goals. The investment objective of the Portfolio
described in this Prospectus is as follows:
 
    -The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers domiciled in
     EAFE countries.
 
    The other portfolios of the Fund are described in other prospectuses which
may be obtained from the Fund at the address and phone number noted on the cover
of this Prospectus. The investment objectives of these other portfolios are
listed below.
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    -The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
     appreciation by investing in accordance with country weightings determined
     by the Adviser in equity securities of non-U.S. issuers which, in the
     aggregate, replicate broad country indices.
 
    -The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Asian issuers.
 
    -The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
     appreciation by investing primarily in equity securities of companies in
     the Asian real estate industry.
 
    -The CHINA GROWTH PORTFOLIO seeks to provide long-term capital appreciation
     by investing primarily in equity securities of issuers in The People's
     Republic of China, Hong Kong and Taiwan.
 
    -The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of emerging country issuers.
 
    -The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of European issuers.
 
    -The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income and
     long-term capital appreciation by investing primarily in equity securities
     of companies in the European real estate industry.
 
    -The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers throughout the world,
     including U.S. issuers.
 
    -The GOLD PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of foreign and domestic issuers engaged in
     gold-related activities.
 
    -The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers.
 
    -The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
     by investing primarily in equity securities of non-U.S. issuers with equity
     market capitalizations of less than $1 billion.
 
                                       6
<PAGE>
    -The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Japanese issuers.
 
    -The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Latin American issuers and,
     from time to time, debt securities issued or guaranteed by Latin American
     governments or governmental entities.
 
    U.S. EQUITY:
 
    -The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by investing
     primarily in corporate equity and equity-linked securities.
 
    -The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing primarily in growth-oriented equity securities of small- to
     medium-sized corporations.
 
    -The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing in growth-oriented equity securities of medium and large
     capitalization companies.
 
    -The MICROCAP PORTFOLIO seeks long-term capital appreciation by investing
     primarily in growth-oriented equity securities of small corporations.
 
    -The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total return by
     investing in equity securities of small- to medium-sized companies which
     the Adviser believes to be undervalued.
 
    -The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of companies that, in the opinion of the
     Adviser, are expected to benefit from their involvement in technology and
     technology-related industries.
 
    -The U.S. EQUITY PLUS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers included in the
     Standard & Poor's 500 Index ("S&P 500").
 
    -The U.S. REAL ESTATE PORTFOLIO seeks to provide above-average current
     income and long-term capital appreciation by investing primarily in equity
     securities of companies in the U.S. real estate industry, including
     substantial investment in real estate investment trusts.
 
    -The VALUE EQUITY PORTFOLIO seeks high total return by investing in equity
     securities which the Adviser believes to be undervalued relative to the
     stock market in general at the time of purchase.
 
    EQUITY AND FIXED INCOME:
 
    -The BALANCED PORTFOLIO seeks high total return while preserving capital by
     investing in a combination of equity securities which the Adviser believes
     to be undervalued and fixed income securities.
 
    FIXED INCOME:
 
    -The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by investing
     primarily in debt securities of government, government-related and
     corporate issuers located in emerging countries.
 
    -The FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
     with the preservation of capital by investing in a diversified portfolio of
     fixed income securities.
 
    -The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
     of return while preserving capital by investing in fixed income securities
     of issuers throughout the world, including U.S. issuers.
 
                                       7
<PAGE>
    -The HIGH YIELD PORTFOLIO seeks to maximize total return by investing in a
     diversified portfolio of high yield fixed income securities that offer a
     yield above that generally available on debt securities in the four highest
     rating categories of the recognized rating services.
 
    -The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a level
     of current income as is consistent with preservation of capital by
     investing primarily in a variety of investment grade mortgage-backed
     securities.
 
    -The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of current
     income consistent with preservation of principal by investing in municipal
     obligations, the interest on which is exempt from federal income tax.
 
    MONEY MARKET:
 
    -The MONEY MARKET PORTFOLIO seeks to maximize current income and preserve
     capital while maintaining high levels of liquidity through investing in
     high quality money market instruments with remaining maturities of one year
     or less.
 
    -The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current tax-exempt
     income and preserve capital while maintaining high levels of liquidity
     through investing in high-quality money market instruments with remaining
     maturities of one year or less which are exempt from federal income tax.
 
   THE CHINA GROWTH, GOLD, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS
   ARE CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley Dean Witter & Co., acts as investment adviser to the Fund and each of
its portfolios. As of March 31, 1998, Morgan Stanley Asset Management Inc. and
its affiliated institutional asset management companies managed assets of
approximately $166 billion, including assets under fiduciary advice. See
"Management of the Fund -- Investment Adviser" and "Management of the Fund --
Administrator."
 
HOW TO INVEST
 
    Class A shares of the Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of the
Portfolio are offered at net asset value with no sales commission, but with a
12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25%, on an
annualized basis, of the Class B shares' average daily net assets. The minimum
initial investment, generally, is $500,000 for Class A shares and $100,000 for
Class B shares of the Portfolio. The minimum initial investment amount is
reduced for certain categories of investors. For additional information on how
to purchase shares and minimum initial investments, see "Purchase of Shares."
 
                                       8
<PAGE>
HOW TO REDEEM
 
    Class A shares or Class B shares of the Portfolio may be redeemed at any
time, without cost, at the net asset value per share of the applicable class
next determined after receipt of the redemption request. The redemption price
may be more or less than the purchase price. Certain redemptions that cause the
value of an account to remain for a continuous 60-day period below the minimum
investment amount for Class A or for Class B shares may result in involuntary
redemption or automatic conversion. For additional information on how to redeem
shares and involuntary redemption or conversion, see "Purchase of Shares" and
"Redemption of Shares."
 
RISK FACTORS
 
    Investing in the Portfolio entails certain risks and considerations of which
an investor should be aware. The Portfolio's share price and investment returns
fluctuate and, when redeemed, an investment in the Portfolio may be worth more
or less than its original cost. The investment policies of the Portfolio may
entail the following risk factors:
 
    -EQUITY SECURITIES.  The Portfolio may invest in equity securities. Prices
     of equity securities fluctuate in response to many factors, including the
     financial health of the issuers and changes in economic and market
     conditions.
 
    -FIXED INCOME SECURITIES.  The Portfolio will be subject to credit risk and
     market risk associated with investment in fixed income securities. Credit
     risk is the possibility that an issuer may be unable to meet scheduled
     principal and interest payments. Market risk is the possibility that a
     change in interest rates or the market's perception of the issuer's
     prospects may adversely affect the value of a fixed income security.
 
    -FOREIGN INVESTMENT.  The Portfolio may invest in the securities of foreign
     issuers. The risks of foreign investment include fluctuations in foreign
     currency values, political events affecting the country of issuance and
     potentially greater market volatility and lower liquidity.
 
    -DERIVATIVES.  The Portfolio may invest in instruments that derive their
     values from those of specified securities, indices, currencies or other
     points of reference. These derivatives, including those used to manage
     risk, are themselves subject to the risks of the different markets in which
     they are traded and, therefore, may or may not serve their intended
     purposes.
 
For additional information about risk factors, see also "Investment Objectives
and Policies" and "Additional Investment Information."
 
                                       9
<PAGE>
                       INVESTMENT OBJECTIVE AND POLICIES
 
    The investment objective of the Portfolio is to provide long-term capital
appreciation. The production of any current income is incidental to this
objective. The Portfolio seeks to achieve its objective by investing primarily
in equity securities of non-U.S. issuers domiciled in the EAFE countries
(defined below). The countries in which the Portfolio primarily will invest are
those comprising the Morgan Stanley Capital International EAFE Index (the
"Index"), which includes Australia, Japan, New Zealand, most nations located in
Western Europe and certain developed countries in Asia, such as Hong Kong and
Singapore (each an "EAFE country," and collectively the "EAFE countries"). The
Portfolio's investment objective is a fundamental policy which may not be
changed without the approval of a majority of the Portfolio's outstanding voting
securities. There is no assurance that the Portfolio will attain its objective.
The investment policies described below are not fundamental policies unless
otherwise noted and may be changed without shareholder approval.
 
    The Portfolio invests primarily in equity securities, which include common
and preferred stocks, convertible securities and rights and warrants to purchase
common stocks and may be denominated in any currency. At least 65% of the total
assets of the Portfolio will be invested in equity securities of issuers in at
least three different EAFE countries under normal circumstances. The Portfolio
also may invest up to 5% of its total assets in the securities of issuers
domiciled in countries which do not comprise part of the Index. By analyzing a
variety of macroeconomic and political factors, the Adviser develops fundamental
projections on comparative interest rates, currencies, corporate profits and
economic growth among the various regions represented in the Index. These
projections are used to establish regional allocation strategies. Within these
regional allocations, the Adviser then selects equity securities among issuers
of a region.
 
    The Adviser's approach in selecting among equity securities within EAFE
countries is oriented to individual stock selection and is value driven. The
Adviser identifies those equity securities which it believes to be undervalued
in relation to the issuer's assets, cash flow, earnings and revenues. In
selecting investments, the Adviser utilizes the research of a number of sources,
including Morgan Stanley Capital International, an affiliate of the Adviser
located in Geneva, Switzerland. Portfolio holdings are regularly reviewed and
subjected to fundamental analysis to determine whether they continue to conform
to the Adviser's investment criteria. Equity securities which no longer conform
to such investment criteria are sold.
 
    Although the Portfolio intends to invest primarily in equity securities
listed on stock exchanges in EAFE countries, the Portfolio may invest in equity
securities that are traded over the counter or that are not listed on a stock
exchange or dealt in a regulated market. As a result of the absence of a public
trading market, such securities may pose liquidity risks. The Portfolio may also
invest in private placements or initial public offerings. Such investments
generally entail short-term liquidity risks.
 
    The Portfolio may invest up to 10% of its total assets in (i) investment
funds with investment objectives similar to that of the Portfolio, and (ii) for
temporary defensive purposes, money market funds and pooled investment vehicles.
If the Portfolio invests in other investment funds, stockholders will bear not
only their proportionate share of the expenses of the Portfolio (including
operating expenses and fees of the Adviser), but also will indirectly bear
similar expenses of the underlying investment fund. Although the Portfolio
anticipates being fully invested in the equity securities described above, the
Portfolio may invest, under normal circumstances for cash management purposes,
up to 35% of its total assets in certain short-term (less than twelve months to
maturity) and medium-term (not greater than five years to maturity) fixed income
securities or hold
 
                                       10
<PAGE>
cash. In addition to the investments and strategies described above, the
Portfolio may invest in certain securities and obligations as set forth in
"Additional Investment Information" below and as described under "Investment
Objectives and Policies" in the Statement of Additional Information.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    FIXED INCOME SECURITIES.  The short-term and medium-term fixed income
securities in which the Portfolio may invest consist of (i) obligations of
governments, agencies or instrumentalities of any member state of the
Organization for Economic Cooperation and Development ("OECD"), including the
United States; (ii) bank deposits and bank obligations (including certificates
of deposit, time deposits and bankers' acceptances) of banks organized under the
laws of any member state of the OECD, including the United States, denominated
in any currency; and (iii) finance company and corporate commercial paper and
other short-term corporate debt obligations of corporations organized under the
laws of any member state of the OECD, including the United States, meeting the
Portfolio's credit quality standards, provided that no more than 20% of the
Portfolio's assets is invested in any one of such issuers. The short-term and
medium-term debt securities in which the Portfolio may invest will be rated
investment grade by recognized rating services such as Moody's Investors
Service, Inc. ("Moody's") or Standard & Poor's Ratings Group ("S&P") (in the
case of Moody's and S&P, meaning rated A or higher by either), or if unrated,
will be determined to be of comparable quality by the Adviser. The Portfolio
will be subject to credit risk and market risk associated with investment in
fixed income securities. Credit risk is the possibility that an issuer may be
unable to meet scheduled principal and interest payments. Market risk is the
possibility that a change in interest rates or the market's perception of the
issuer's prospects, may adversely affect the value of a fixed income security.
 
    FOREIGN CURRENCY FORWARD CONTRACTS.  The Portfolio may enter into foreign
currency forward contracts ("forward contracts") that provide for the purchase
or sale of an amount of a specified currency at a future date. The Portfolio may
use such contracts to protect against a decline in a foreign currency against
the U.S. dollar between the trade date and settlement date when the Portfolio
purchases or sells securities, lock in the U.S. dollar value of dividends and
interest on securities held by the Portfolio, and generally to protect the U.S.
dollar value of securities held by the Portfolio against exchange rate
fluctuation. While forward contracts may limit losses as a result of exchange
rate fluctuations, they will also limit any gains that might otherwise have been
realized. The Portfolio's Custodian may be required to place cash or liquid
securities in a segregated account in an amount equal to the value of the
Portfolio's total assets committed to the consummation of forward contracts. If
the value of the securities placed in the segregated account declines,
additional cash or securities will be placed in the account on a daily basis so
that the value of the account will be at least equal to the amount of the
Portfolio's commitments with respect to such contracts.
 
    FOREIGN INVESTMENT.  The Portfolio may invest in the securities of foreign
issuers. Investment in securities of foreign issuers involves investment risks
somewhat different from those affecting securities of U.S. issuers. The
Portfolio's investments will be subject to political and economic events that
affect the countries in which it invests. Foreign issuers may be subject to
different accounting, auditing and financial standards and requirements. There
also may be less government supervision and regulation of foreign securities
exchanges, brokers and listed companies than in the United States. Many foreign
securities markets have substantially less traded volume than U.S. national
securities exchanges and, therefore, securities of some foreign issuers are less
liquid and more volatile than securities of comparable U.S. issuers. Brokerage
commissions and other
 
                                       11
<PAGE>
transaction costs on foreign securities exchanges are generally higher than in
the United States. Dividends and interest paid by foreign issuers may be subject
to withholding and other foreign taxes, which may decrease the net return on
foreign investments as compared to dividends and interest paid to the Portfolio
by domestic companies. Investments in securities of foreign issuers are
generally denominated in foreign currencies and, since the Portfolio may
temporarily hold uninvested reserves in bank deposits in foreign currencies, the
value of the Portfolio's assets as measured in U.S. dollars may be affected
favorably or unfavorably by changes in currency exchange rates and exchange
control regulations, and the Portfolio may incur costs in connection with
conversions between various currencies.
 
    INVESTMENT FUNDS.  Some foreign countries have laws and regulations that
currently preclude direct foreign investment in the securities of their
companies. However, indirect foreign investment in the securities of companies
listed and traded on the stock exchanges in these countries is sometimes
permitted through investment funds which have been specifically authorized. The
Portfolio may invest in these investment funds subject to the provisions of the
Investment Company Act of 1940, as amended (the "1940 Act"), and other
applicable laws. If the Portfolio invests in such investment funds, the
Portfolio's shareholders will bear not only their proportionate share of the
expenses of the Portfolio (including operating expenses and the fees of the
Adviser), but also will indirectly bear similar expenses of the underlying
investment funds. Certain of these investment funds are advised by the Adviser.
The Portfolio may, to the extent permitted under the 1940 Act and other
applicable law, invest in these investment funds.
 
    LOANS OF PORTFOLIO SECURITIES.  The Portfolio may lend its securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing net investment income. These loans must be secured
continuously by cash or equivalent collateral or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be risks of delay in recovery of the securities or even loss
of rights in the collateral should the borrower of the securities fail
financially. The Portfolio will not enter into securities loan transactions
exceeding in the aggregate 33 1/3% of the market value of the Portfolio's total
assets.
 
    MONEY MARKET INSTRUMENTS.  The Portfolio is permitted to invest in money
market instruments, although the Portfolio intends to stay invested in
securities satisfying its primary investment objective to the extent practical.
Consistent with its investment policies, the Portfolio may make money market
investments pending other investment or settlement for liquidity. In addition,
the Portfolio may invest in money market instruments for temporary defensive
purposes during adverse market conditions. The money market investments
permitted for the Portfolio include: obligations of the U.S. Government and its
agencies and instrumentalities, obligations of foreign sovereignties, commercial
paper, bank obligations (including certificates of deposit), other debt
securities and repurchase agreements.
 
    NON-PUBLICLY TRADED SECURITIES, PRIVATE PLACEMENTS AND RESTRICTED
SECURITIES.  The Portfolio may invest in securities that are neither listed on a
stock exchange nor traded over-the-counter, including privately placed
securities. Such unlisted equity securities may involve a higher degree of
business and financial risk that can result in substantial losses. As a result
of the absence of a public trading market for these securities, they may be less
liquid than publicly traded securities. Although these securities may be resold
in privately negotiated transactions, the prices realized from these sales could
be less than those originally paid by the Portfolio or less than what may be
considered the fair value of such securities. Further, companies whose
securities are not publicly traded may not be subject to the disclosure and
other investor protection requirements which might be
 
                                       12
<PAGE>
applicable if their securities were publicly traded. If such securities are
required to be registered under the securities laws of one or more jurisdictions
before being resold, the Portfolio may be required to bear the expenses of
registration.
 
    As a general matter, the Portfolio may not invest more than 15% of its net
assets in illiquid securities, including securities for which there is no
readily available secondary market. Also, as a general matter, the Portfolio may
not invest more than 10% of its total assets in securities that are restricted
from sale to the public without registration ("Restricted Securities") under the
Securities Act of 1933, as amended (the "1933 Act"). However, the Portfolio may
invest up to 25% of its total assets in liquid Restricted Securities that can be
offered and sold to qualified institutional buyers under Rule 144A under that
Act ("Rule 144A Securities"). The Board of Directors has adopted guidelines and
delegated to the Adviser, subject to the supervision of the Board of Directors,
the daily function of determining and monitoring the liquidity of Rule 144A
Securities. Rule 144A Securities may become illiquid if qualified institutional
buyers are not interested in acquiring the securities.
 
    REPURCHASE AGREEMENTS.  The Portfolio may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines established by
the Fund's Board of Directors. In a repurchase agreement, the Portfolio buys a
security from a seller that has agreed to repurchase it at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of the
agreement. The term of these agreements is usually from overnight to one week
and never exceeds one year. A repurchase agreement may be viewed as a fully
collateralized loan of money by the Portfolio to the seller. The Portfolio
always receives securities with a market value at least equal to the purchase
price (including accrued interest) as collateral, and this value is maintained
during the term of the agreement. If the seller defaults and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with respect to the seller, the Portfolio's realization upon the
collateral may be delayed or limited. The Portfolio may not enter into
repurchase agreements with more than seven days to maturity if, as a result,
more than 15% of the market value of the Portfolio's net assets would be
invested in such repurchase agreements and in other investments for which market
quotations are not readily available or which are otherwise illiquid.
 
    TEMPORARY INVESTMENTS.  During periods in which the Adviser believes changes
in economic, financial or political conditions make it advisable, each Portfolio
may, for temporary defensive purposes, invest up to 100% of its total assets in
certain short-term and medium-term debt obligations or hold cash. The short-term
and medium-term debt obligations in which a Portfolio may invest consist of (i)
obligations of the U.S. or foreign governments, their respective agencies or
instrumentalities; (ii) money market instruments; and (iii) instruments
denominated in any currency issued by international development agencies.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  The Portfolio may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Delivery of and payment for these securities may take
as long as a month or more after the date of the purchase commitment but will
take place no more than 120 days after the trade date. The Portfolio will
maintain with the custodian a separate account with a segregated portfolio of
cash or liquid securities in an amount at least equal to these commitments. The
payment obligation and the interest rates that will be received are each fixed
at the time the Portfolio enters into the commitment and no interest accrues to
the Portfolio until settlement. Thus, it is possible that the market value at
the time of settlement could be higher or lower than the
 
                                       13
<PAGE>
purchase price if, among other factors, the general level of interest rates has
changed. It is a current policy of the Portfolio not to enter into when-issued
commitments exceeding in the aggregate 15% of the market value of the
Portfolio's total assets less liabilities, other than the obligations created by
these commitments.
 
DERIVATIVE PRODUCTS (DERIVATIVES)
 
    The Portfolio is permitted to utilize various exchange-traded and
over-the-counter derivative instruments and derivative securities, both for
hedging and non-hedging purposes. Permitted derivative products include, but are
not limited to: futures contracts ("futures"); forward contracts ("forwards");
options; swaps, caps, collars and floors; structured notes; and other derivative
products yet to be developed, so long as these new products are used in a manner
consistent with the objective of the Portfolio. These derivative products may be
based upon a wide variety of underlying rates, indices, instruments, securities
and other products, such as interest rates, foreign currencies, foreign and
domestic fixed income and equity securities, groups or "baskets" of securities
and securities indices (for each derivative product, the "underlying").
Exclusive of forward foreign currency contracts and any derivative products used
for hedging purposes, the Portfolio will limit its use of derivative products to
33 1/3% of its total assets, measured by the aggregate notional amount of
outstanding derivative products.
 
    The Portfolio may use derivative products under a number of different
circumstances to further its investment objective. For example, the Portfolio
may purchase derivatives to gain exposure to a market quickly in response to
changes in the Portfolio's investment strategy, upon the inflow of investable
cash or when the derivative provides greater liquidity than the underlying
market. The Portfolio may also use derivatives when it is restricted from
directly owning the "underlying" or when derivatives provide a pricing advantage
or lower transaction costs. The Portfolio also may purchase combinations of
derivatives in order to gain exposure to an investment in lieu of actually
purchasing such investment. Derivatives may also be used by the Portfolio for
hedging or risk management purposes and in other circumstances when the Adviser
believes it advantageous to do so consistent with the Portfolio's investment
objective and policies. The Portfolio will not use derivatives in a manner that
creates leverage, except to the extent that the use of leverage is expressly
permitted by the Portfolio's investment policies, and then only in a manner
consistent with such policies.
 
    The use of derivative products is a highly specialized activity which
involves investment techniques and risks different from those associated with
ordinary portfolio securities transactions. If the Adviser is incorrect in
forecasts of market values, interest rates, and currency exchange rates, the
investment performance of the Portfolio will be less favorable than it would
have been if these investment techniques had not been used.
 
    Some of the derivative products in which the Portfolio may invest and some
of the risks related thereto are described in more detail below.
 
FUTURES CONTRACTS (FUTURES) AND FORWARD CONTRACTS (FORWARDS)
 
    The Portfolio may purchase and sell futures contracts, such as futures on
securities indices, baskets of securities, foreign currencies and interest rates
of the type generally known as financial futures. These are standardized
contracts that are bought and sold on organized exchanges. A futures contract
obligates a party to buy or sell a specific amount of the "underlying", such as
for example, a particular foreign currency, on a specified future date at a
specified price or to settle the value in cash.
 
                                       14
<PAGE>
    The Portfolio may also purchase and sell forward contracts, such as forward
rate agreements and other financial forward contracts. The Portfolio may also
use foreign currency forward contracts which are separately discussed elsewhere
in this Prospectus. See "Foreign Currency Forward Contracts" above. These
forward contracts are privately negotiated and are bought and sold in the
over-the-counter market. Like a future, a forward contract obligates a party to
buy or sell a specific amount of the underlying on a specified future date at a
specified price. The terms of the forward contract are customized. Forward
contracts, like other over-the-counter contracts that are negotiated directly
with an individual counterparty, subject the Portfolio to the risk of
counterparty default.
 
    In some cases, the Portfolio may be able to use either futures contracts,
forward contracts or exchange-traded or over-the-counter options to accomplish
similar purposes. In all cases, the Portfolio will use these products only as
permitted by applicable laws and regulations. Some of the ways in which the
Portfolio may utilize futures contracts, forward contracts and related options
are as follows:
 
    The Portfolio may sell securities index futures contracts and/or index
options thereon in anticipation of or during a market decline to attempt to
offset the decrease in market value of investments in its portfolio, or may
purchase securities index futures or options in order to gain market exposure.
There currently are limited securities index futures and options on such futures
in many countries, particularly emerging countries. The nature of the strategies
adopted by the Adviser, and the extent to which those strategies are used, may
depend on the development of such markets. The Portfolio may also purchase and
sell foreign currency futures to hedge its respective holdings and commitments
against changes in the level of future currency rates or to adjust its exposure
to a particular currency.
 
    The Portfolio may engage in transactions in interest rate futures and
related products. The value of these contracts rises and falls inversely with
changes in interest rates. The Portfolio may engage in such transactions to
hedge its holdings of debt instruments against future changes in interest rates
or for other purposes.
 
    The Portfolio may also purchase or sell futures and forwards on other
financial instruments, such as U.S. Government securities and certificates of
deposit. The value of these contracts also rises and falls inversely with
changes in interest rates. The Portfolio may engage in financial futures and
forward contracts for both hedging and non-hedging purposes.
 
    Gains and losses on futures contracts, forward contracts and related options
depend on the Advisers ability to predict correctly the direction of securities
prices, interest rates and other economic factors. Other risks associated with
the use of these instruments include (i) imperfect correlation between the
change in market value of investments held by the Portfolio and the prices of
derivative products relating to investments purchased or sold by the Portfolio,
and (ii) possible lack of a liquid secondary market for a derivative product and
the resulting inability to close out a position. The risk that the Portfolio
will be unable to close out a position will be minimized by only entering into
transactions for which there appears to be a liquid exchange or secondary
market. In some strategies, the risk of loss in trading on futures and related
transactions can be substantial, due both to the low margin deposits required
and the extremely high degree of leverage involved in pricing.
 
    Under rules adopted by the Commodity Futures Trading Commission (the
"CFTC"), the Portfolio may, without registering with the CFTC as a Commodity
Pool Operator, enter into futures contracts and options
 
                                       15
<PAGE>
thereon for both hedging and non-hedging purposes, provided that not more than
5% of the Portfolio's total assets at the time of entering the transaction are
required as margin and option premiums to secure obligations under such
contracts relating to non-bona fide hedging activities.
 
OPTION TRANSACTIONS
 
    The Portfolio may seek to increase its returns or may hedge its portfolio
investments through options transactions with respect to individual securities,
indices or baskets in which the Portfolio may invest; other financial
instruments; and foreign currency. Various options may be purchased and sold on
either the exchange-traded or over-the-counter markets.
 
    The Portfolio may purchase put and call options. Purchasing a put option
gives the Portfolio the right, but not the obligation, to sell the underlying
(such as a securities index or a particular foreign currency) at the exercise
price either on a specific date or during a specified exercise period.
Purchasing a call option gives the Portfolio a similar right, but not the
obligation, to purchase the underlying. The purchaser pays a premium to the
seller (also known as the writer) of the option.
 
    The Portfolio also may write put and call options on investments held in its
portfolio, as well as foreign currency options. The Portfolio that has written
an option receives a premium that increases the Portfolio's return on the
underlying in the event the option expires unexercised or is closed out at a
profit. However, by writing a call option, the Portfolio will limit its
opportunity to profit from an increase in the market value of the underlying
above the exercise price of the option. By writing a put option, the Portfolio
will be exposed to the amount by which the price of the underlying is less than
the strike price.
 
    By writing an option, the Portfolio incurs an obligation either to buy (in
the case of a put option) or sell (in the case of a call option) the underlying
from the purchaser of the option at the option's exercise price, upon exercise
by the purchaser. Pursuant to guidelines established by the Board of Directors,
the Portfolio may only write options that are "covered." A covered call option
means that until the expiration of the option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will continue to own (i) the underlying; (ii) securities or instruments
convertible or exchangeable without the payment of any consideration into the
underlying; or (iii) a call option on the same underlying with a strike price no
higher than the price at which the underlying was sold pursuant to a short
option position. In the case of a put option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will own another put option on the same underlying with an equal or higher
strike price.
 
    There currently are limited options markets in many countries, particularly
emerging market countries, and the nature of the strategies adopted by the
Adviser and the extent to which those strategies are used will depend on the
development of these options markets. The primary risks associated with the
Portfolio's use of options as described include (i) imperfect correlation
between the change in market value of investments held, purchased or sold by the
Portfolio and the prices of options relating to such investments, and (ii)
possible lack of a liquid secondary market for an option.
 
INTEREST RATE, CURRENCY, COMMODITY AND EQUITY SWAPS, CAPS, COLLARS AND FLOORS
 
    Swaps are privately negotiated over-the-counter derivative products in which
two parties agree to exchange payment streams calculated in relation to a rate,
index, instrument or certain securities and a particular "notional amount." As
with many of the other derivative products available to the Portfolio, the
underlying may
 
                                       16
<PAGE>
include an interest rate (fixed or floating), a currency exchange rate, a
commodity price index, and a security, securities index or a combination
thereof. A great deal of flexibility is possible in the way the products may be
structured, with the effect being that the parties may have exchanged amounts
equal to the return on one rate, index or group of securities for another. For
example, in a simple fixed-to-floating interest rate swap, one party makes
payments equivalent to a fixed interest rate, and the other makes payments
equivalent to a specified interest rate index. The Portfolio may engage in
simple or more complex swap transactions involving a wide variety of
underlyings. The currency swaps that the Portfolio may enter will generally
involve an agreement to pay interest streams in one currency based on a
specified index in exchange for receiving interest streams denominated in
another currency. Such swaps may involve initial and final exchanges that
correspond to the agreed upon notional amount.
 
    Caps, collars and floors are privately-negotiated option-based derivative
products. The Portfolio may use one or more of these products in addition to or
in lieu of a swap involving a similar rate or index. As in the case of a put or
call option, the buyer of a cap or floor pays a premium to the writer. In
exchange for that premium, the buyer receives the right to a payment equal to
the differential if the specified index or rate rises above (in the case of a
cap) or falls below (in the case of a floor) a pre-determined strike level. As
in the case of swaps, obligations under caps and floors are calculated based
upon an agreed notional amount, and like most swaps (other than foreign currency
swaps), the entire notional amount is not exchanged and thus is not at risk. A
collar is a combination product in which the same party, such as the Portfolio,
buys a cap from and sells a floor to the other party. As with put and call
options, the amount at risk is limited for the buyer, but, if the cap or floor
is not hedged or covered, may be unlimited for the seller. Under current market
practice, caps, collars and floors between the same two parties are generally
documented under the same "master agreement." In some cases, options and forward
agreements may also be governed by the same master agreement. In the event of a
default, amounts owed under all transactions entered into under, or covered by,
the same master agreement would be netted and only a single payment would be
made.
 
    Swaps, caps, collars and floors are credit-intensive products. When the
Portfolio that enters into a swap transaction it bears the risk of default, i.e.
nonpayment, by the other party. The guidelines under which the Portfolio enters
derivative transactions, along with some features of the transactions
themselves, are intended to reduce these risks to the extent reasonably
practicable, although they cannot eliminate the risks entirely. Under guidelines
established by the Board of Directors, the Portfolio may enter into swaps only
with parties that meet certain credit rating guidelines. Consistent with current
market practices, the Portfolio will generally enter into swap transactions on a
net basis, and all swap transactions with the same party will be documented
under a single master agreement to provide for net payment upon default. In
addition, the Portfolios obligations under an agreement will be accrued daily
(offset against any amounts owing to the Portfolio) and any accrued, but unpaid,
net amounts owed to the other party to a master agreement will be covered by the
maintenance of a segregated account consisting of cash or liquid securities.
 
    Interest rate and total rate of return (fixed income or equity) swaps
generally do not involve the delivery of securities, other underlying assets, or
principal. In such case, if the other party to an interest rate or total rate of
return swap defaults, the Portfolio's risk of loss will consist of the payments
that the Portfolio is contractually entitled to receive from the other party.
This may not be true for currency swaps that require the delivery of the entire
notional amount of one designated currency in exchange for the other. If there
is a default by the other party, the Portfolio may have contractual remedies
pursuant to the agreements related to the transaction.
 
                                       17
<PAGE>
STRUCTURED NOTES
 
    Structured notes are derivative securities for which the amount of principal
repayment and/or interest payments is based upon the movement of one or more
factors. These factors include, but are not limited to, currency exchange rates,
interest rates (such as the prime lending rate and LIBOR) and stock indices,
such as the S&P 500. In some cases, the impact of the movements of these factors
may increase or decrease through the use of multipliers or deflators. The
Portfolio may use structured notes to tailor its investments to the specific
risks and returns the Adviser wishes to accept while avoiding or reducing
certain other risks.
 
                             INVESTMENT LIMITATIONS
 
    The Portfolio is a non-diversified investment company under the 1940 Act,
which means that the Portfolio is not limited by the 1940 Act in the proportion
of its total assets that may be invested in the obligations of a single issuer.
Thus, the Portfolio may invest a greater proportion of its total assets in the
securities of a smaller number of issuers and, as a result, will be subject to
greater risk with respect to its respective portfolio securities. Nevertheless,
the Portfolio intends to comply with the more limited diversification
requirements imposed by the Internal Revenue Code of 1986, as amended (the
"Code"), for qualification as a regulated investment company.
 
    The Portfolio also operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of the
holders of a majority of the Portfolio's outstanding shares and certain
non-fundamental investment limitations that may be changed without shareholder
approval. For additional information on the fundamental and non-fundamental
investment limitations, see "Investment Limitations" in the Statement of
Additional Information.
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and the Portfolio. The Adviser provides investment
advice and portfolio management services pursuant to an Investment Advisory
Agreement and, subject to the supervision of the Fund's Board of Directors,
makes each Portfolio's day-to-day investment decisions, arranges for the
execution of portfolio transactions and generally manages each Portfolio's
investments. The Adviser is entitled to receive an annual management fee,
payable quarterly, equal to 0.80% of the average daily net assets of the
International Magnum Portfolio.
 
    The fees of the Portfolio are higher than those of most investment companies
because the Portfolio invests internationally. The Adviser believes that the
fees are comparable to those of other investment companies that invest
internationally. The Adviser has voluntarily agreed to a reduction in the fees
payable to it and to reimburse the Portfolio, if necessary, if such fees would
cause total annual operating expenses of the Portfolio to exceed 1.00% of the
average daily net assets of the Class A shares of the Portfolio and 1.25% of the
average daily net assets of the Class B shares of the Portfolio.
 
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to customers in the
United States and abroad. Morgan Stanley Dean Witter & Co. ("MSDW") is the
direct parent of the Adviser and Morgan Stanley. MSDW is a preeminent global
financial services firm that maintains leading market positions in each of its
three primary businesses -- securities, asset management and credit services. At
 
                                       18
<PAGE>
March 31, 1998, the Adviser, together with its affiliated institutional asset
management companies, managed assets of approximately $166 billion, including
assets under fiduciary advice. See "Management of the Fund" in the Statement of
Additional Information.
 
    PORTFOLIO MANAGER.  FRANCINE J. BOVICH. Francine J. Bovich, a Managing
Director of Morgan Stanley and MSAM, joined the Adviser in 1993. She is
responsible for portfolio management and communication of the Adviser's asset
allocation strategy to institutional investor clients. Previously, Ms. Bovich
was a Principal and Executive Vice President of Westwood Management Corp.
("Westwood"), a registered investment adviser. Before joining Westwood, she was
a Managing Director of Citicorp Investment Management, Inc. (now Chancellor
Capital Management), where she was responsible for the Institutional Investment
Management group. Ms. Bovich began her investment career with Banker's Trust
Company. She holds a B.A. in Economics from Connecticut College and an M.B.A. in
Finance from New York University.
 
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the officers and the
Board of Directors of the Fund and include day-to-day administration of matters
related to the corporate existence of the Fund, maintenance of its records,
preparation of reports, supervision of the Fund's arrangements with its
custodian and assistance in the preparation of the Fund's registration
statements under federal laws. The Administration Agreement also provides that
the Administrator, through its agents, will provide dividend disbursing and
transfer agent services to the Fund. For its services under the Administration
Agreement, the Fund pays the Adviser a monthly fee which on an annual basis
equals 0.15% of the average daily net assets of the Portfolio.
 
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors such administrative services provided by CGFSC.
Their services are also subject to the supervision of the Board of Directors of
the Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of the Portfolio upon the terms and at the current offering
price described in this Prospectus. Morgan Stanley is not obligated to sell any
certain number of shares of the Fund.
 
    The Portfolio currently offers only the classes of shares offered by this
Prospectus. The Portfolio may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares pursuant to Rule 12b-1 under the 1940 Act (the "Plan"). Under the Plan,
the Distributor is entitled to receive from the Portfolio a distribution fee,
which is accrued daily and paid quarterly, of 0.25% of the Class B shares'
average daily net assets on an annualized basis. Each Plan is designed to
compensate the Distributor for its services in connection
 
                                       19
<PAGE>
with distribution assistance. The Distributor may retain any portion of the fee
that it does not expend in meeting its obligations to the Fund. The Distributor
may compensate financial intermediaries, plan fiduciaries and administrators for
providing distribution-related services, including account maintenance services,
to shareholders (including, where applicable, underlying beneficial owners) of
Class B shares.
 
    EXPENSES.  The Portfolio is responsible for payment of certain other fees
and expenses (including legal fees, accountants' fees, custodial fees and
printing and mailing costs) as specified in its agreements with the Adviser and
Morgan Stanley.
 
    YEAR 2000.  The management and distribution services provided to the Fund by
the Adviser and Morgan Stanley depend on the smooth functioning of their
computer systems. Many computer software systems in use today cannot recognize
the year 2000, but revert to 1900 or some other date, due to the manner in which
dates were encoded and calculated. That failure could have a negative impact on
the handling of securities trades, pricing and account services. The Adviser and
Morgan Stanley have been actively working on necessary changes to their own
computer systems to deal with the year 2000 problem and expect that their
systems will be adapted before that date. There can be no assurance, however,
that they will be successful. In addition, other unaffiliated service providers
may be faced with similar problems. The Adviser and Morgan Stanley are
monitoring their remedial efforts, however, there can be no assurance that they
and the services they provide will not be adversely affected.
 
    In addition, it is possible that the markets for securities in which the
Portfolio invests may be detrimentally affected by computer failures throughout
the financial services industry beginning January 1, 2000. Improperly
functioning trading systems may result in settlement problems and liquidity
issues. In addition, corporate and governmental data processing errors may
result in production problems for individual companies and overall economic
uncertainties. Earnings of individual issuers will be affected by remediation
costs, which may be substantial and may be reported inconsistently in U.S. and
foreign financial statements. Accordingly, the Portfolio's investments may be
adversely affected.
 
                               PURCHASE OF SHARES
 
    Class A shares and Class B shares of the Portfolio may be purchased at the
net asset value per share next determined after receipt by the Fund of a
purchase order as described under "Methods of Purchase." The net asset value per
share of the Portfolio is calculated on days that the New York Stock Exchange
("NYSE") and Chase (the "Custodian Bank") are open for business as of the close
of trading of the NYSE, normally 4:00 p.m. Eastern Time (the "Pricing Time").
 
MINIMUM INVESTMENT
 
    The minimum initial investment is $500,000 for Class A shares and $100,000
for Class B shares of the Portfolio. These minimums may be waived at the
discretion of the Adviser for certain types of investors, including trust
departments, brokers, dealers, agents, financial planners, financial services
firms, investment advisers or various retirement and deferred compensation plans
("Financial Intermediaries"), certain accounts managed by the Adviser and its
affiliates ("Managed Accounts"), and certain employees and customers of Morgan
Stanley and its affiliates. The Fund's determination of an investor's
eligibility to purchase shares of a given class will take precedence over the
investor's selection of a class.
 
                                       20
<PAGE>
METHODS OF PURCHASE
 
    Shares may be purchased directly from the Fund by Federal Funds wire, by
bank wire or by check. Investors may also invest in the Portfolio by purchasing
shares through Financial Intermediaries that have made arrangements with Morgan
Stanley. Some Financial Intermediaries may charge an additional service or
transaction fee. If a purchase is canceled due to nonpayment or because your
check does not clear, you will be responsible for any loss the Fund or its
agents incur. If you are already a shareholder, the Fund may redeem shares from
your account(s) to reimburse the Fund or its agents for any loss. In addition,
you may be prohibited or restricted from making future investments in the Fund.
 
    FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire Federal
Funds to the Fund's bank account. Federal Funds purchase orders will be accepted
only on a day on which the Fund and the Custodian Bank are open for business.
Your bank may charge a service fee for wiring Federal Funds. In order to ensure
proper handling of your purchase by Federal Funds wire, please follow these
steps:
 
    1.  Place your order by telephoning the Fund at 1-800-548-7786. A Fund
       representative will request certain purchase information and provide you
       with a confirmation number.
 
    2.  Instruct your bank to wire the specified amount to the Fund's Wire
       Concentration Bank Account as follows:
 
        The Chase Manhattan Bank
       One Manhattan Plaza
       New York, NY 10081-1000
       ABA# 021000021
       DDA# 910-2-733293
       Attn: Morgan Stanley Institutional Fund, Inc.
       Ref: (Portfolio name, your account number, your account name)
       Please call the Fund at 1-800-548-7786 prior to wiring the funds.
 
    3.  Complete and sign the Account Registration Form and mail it to the
       address shown thereon.
 
    When a purchase order is received prior to the Pricing Time and Federal
Funds are received prior to the close of the Federal Funds Wire Control Center
("FFWCC") (normally 6:00 p.m. Eastern Time), the purchase will be executed at
the net asset value computed on the date of receipt. Purchases for which an
order is received after the Pricing Time or for which Federal Funds are received
after the close of the FFWCC, will be executed at the net asset value next
determined. Certain institutional investors and financial institutions have
entered into an arrangement with Morgan Stanley, pursuant to which they may
place orders prior to the Pricing Time, but make payment in Federal Funds for
those shares on the following business day.
 
    BANK WIRE.  A purchase of shares by bank wire must follow the same procedure
as for a Federal Funds wire, described above. However, depending on the time the
bank wire is sent and which bank is handling the wire, money transferred by bank
wire may or may not be converted into Federal Funds prior to the close of the
FFWCC. Prior to conversion to Federal Funds and receipt by the Fund, an
investor's money will not be invested.
 
                                       21
<PAGE>
    CHECK.  An account may be opened by completing and signing an Account
Registration Form and mailing it, together with a check payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio name]" to:
 
    Morgan Stanley Institutional Fund, Inc.
    P.O. Box 2798
    Boston, Massachusetts 02208-2798
 
    The Fund ordinarily is credited with Federal Funds within one business day
of deposit of a check. Thus, a purchase of shares by check ordinarily will be
credited to your account at the net asset value per share determined on the next
business day after receipt. An investor's money will not be invested prior to
crediting of Federal Funds.
 
    INVESTMENT THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to receive purchase and
redemption orders from underlying beneficial owners, such as retirement plan
participants, generally on each business day. Each business evening, the
Financial Intermediary aggregates all orders received from underlying beneficial
owners prior to the Pricing Time on that business day and places a net purchase
and/or redemption order(s) by the morning of the next business day. These orders
normally are executed at the net asset value that was computed for the Portfolio
as of the close of the previous business day.
 
    ADDITIONAL INVESTMENTS.  You may purchase additional shares for your account
at any time by purchasing shares at net asset value by any of the methods
described above. The minimum additional investment generally is $1,000 for the
Portfolio. The minimum additional investment may be lower for certain accounts,
described above under "Minimum Investment." For purchases directly from the
Fund, your account name, the Portfolio name and the class selected must be
specified in the letter or wire to assure proper crediting to your account.
 
INVOLUNTARY CONVERSION AND REDEMPTION OF NEW ACCOUNT SHARES
 
    Class A and Class B shares of the Portfolio may be subject to the
involuntary conversion and redemption features described below. The conversion
and redemption features may be waived at the discretion of the Adviser for
shares held in a Managed Account and shares purchased through a Financial
Intermediary. Accounts that were open prior to January 2, 1996 are not subject
to involuntary conversion or redemption. The Fund reserves the right to modify
or terminate the conversion or redemption features of the shares at any time
upon 60 days notice to shareholders.
 
    CONVERSION FROM CLASS A TO CLASS B SHARES.  If the value of an account
containing Class A shares falls below $500,000 (but remains at or above
$100,000) because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $500,000 (but remains at or
above $100,000) for a continuous 60-day period, the Class A shares in such
account will convert to Class B shares and will be subject to the distribution
fee and other features applicable to Class B shares. The Fund will not convert
Class A shares to Class B shares based solely upon changes in the market that
reduce the net asset value of shares. Under current tax law, conversion between
share classes is not a taxable event to the shareholder.
 
    CONVERSION FROM CLASS B TO CLASS A SHARES.  If the value of an account
containing Class B shares increases to $500,000 or more, whether due to
shareholder purchases or market activity, the Class B shares will convert to
Class A shares. Class B shares purchased through a Financial Intermediary that
has entered into an arrangement with the Fund for the purchase of such shares
may not be converted. Under current tax law, such
 
                                       22
<PAGE>
conversion is not a taxable event to the shareholder. Class A shares converted
from Class B shares are subject to the same minimum account size requirements as
are applicable to New Accounts containing Class A shares described above.
 
    INVOLUNTARY REDEMPTION OF SHARES.  If the value of an account falls below
$100,000 because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $100,000 for a continuous
60-day period, the shares in such account will be subject to redemption by the
Fund. The Fund will not redeem shares based solely upon changes in the market
that reduce the net asset value of shares. If redeemed, redemption proceeds will
be promptly paid to the shareholder.
 
                              REDEMPTION OF SHARES
 
    Class A and Class B shares of the Portfolio may be redeemed at any time and
without charge at the net asset value per share next determined after receipt by
the Fund of a redemption order as described under "Methods of Redemption."
Redemption proceeds may be more or less than the purchase price of your shares
depending on, among other factors, the market value of the investment securities
held by the Portfolio.
 
METHODS OF REDEMPTION
 
    Shares may be redeemed directly from the Fund by mail or by telephone.
However, shares purchased through a Financial Intermediary must be redeemed
through a Financial Intermediary. Certain Financial Intermediaries may charge an
additional service or transaction fee.
 
    BY MAIL.  The Portfolio will redeem shares upon receipt of a redemption
request in "good order." Redemption requests may be sent by regular mail to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798 or, by overnight courier, to Morgan Stanley Institutional Fund, Inc.,
c/o Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913.
 
    "Good order" means that the request to redeem shares must include the
following:
 
    1.  A letter of instruction or a stock assignment specifying the class and
       number of shares or dollar amount to be redeemed, signed by all
       registered owners of the shares in the exact names in which they are
       registered;
 
    2.  Any required signature guarantees; and
 
    3.  Other supporting legal documents, if required, in the case of estates,
       trusts, guardianships, custodianships, corporations, pension and
       profit-sharing plans and other organizations.
 
    Redemption requests received in "good order" prior to the Pricing Time will
be executed at the net asset value computed on the date of receipt. Redemption
requests received after the Pricing Time will be executed at the next determined
net asset value. Shareholders who are uncertain of requirements for redemption
by mail should consult with a Fund representative.
 
    BY TELEPHONE.  If you have previously elected the Telephone Redemption
Option on the Account Registration Form, you can redeem Portfolio shares by
calling the Fund and requesting that the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. To change the commercial bank or account designated to receive
redemption proceeds, send a written request to
 
                                       23
<PAGE>
the Fund at the address above. Requests to change the bank or account must be
signed by each shareholder and each signature must be guaranteed. The telephone
redemption option may be difficult to implement at times, particularly during
volatile market conditions. If you experience difficulty in making a telephone
redemption, you may redeem shares by mail as described above.
 
    The Fund and the Transfer Agent will employ reasonable procedures to confirm
that instructions communicated by telephone are genuine. An investor may be
required to provide personal identification information at the time an account
is opened and prior to effecting each telephone transaction. In addition, all
telephone transaction requests will be recorded and investors may be required to
provide additional telecopied written instructions regarding transaction
requests. Neither the Fund nor the Transfer Agent will be responsible for any
loss, liability, cost or expense for following instructions received by
telephone that either of them reasonably believes to be genuine.
 
    REDEMPTION THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to accept redemption
requests from underlying beneficial owners. These redemptions may be processed
in the same way as purchases made through such Financial Intermediaries, as
described above.
 
FURTHER REDEMPTION INFORMATION
 
    The Fund normally makes payment for all shares redeemed within one business
day of receipt of the request, and in no event more than seven days after
receipt of a redemption request in good order. However, payments to investors
redeeming shares which were purchased by check will not be made until payment
for the purchase has been collected, which may take up to eight days after the
date of purchase. The Fund may suspend the right of redemption or postpone the
date upon which redemptions are effected at times when the NYSE is closed, or
under any emergency conditions as determined by the Securities and Exchange
Commission (the "Commission").
 
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of the Portfolio to make payment in
cash, the Fund may pay redemption proceeds in whole or in part by a
distribution-in-kind of readily marketable portfolio securities in accordance
with applicable rules of the Commission. Shareholders may incur brokerage
charges on the sale of portfolio securities received in payment of redemptions.
 
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required to verify the identity of the person who has authorized
certain redemptions. Please contact the Fund or see the Statement of Additional
Information for further information.
 
                         ACCOUNT POLICIES AND SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares of the Portfolio that you own for shares of any
other available portfolio(s) of the Fund, subject to certain limitations. You
cannot exchange for shares of the International Equity, Emerging Markets, Small
Cap Value Equity, Balanced or Gold Portfolios because they are currently closed
to new investors. In addition, certain portfolios may be unavailable to
shareholders who purchased portfolio shares through a Financial Intermediary.
Contact your Financial Intermediary to determine which portfolios are available
for exchange.
 
                                       24
<PAGE>
    Before you make an exchange, you should read the prospectus of the
portfolio(s) in which you seek to invest. The class of shares you receive in the
exchange will be determined in the same manner as any other purchase of shares,
including minimum initial investment and account size requirements, and will not
be based on the class of shares you surrender for the exchange. Exchange
transactions are treated as a redemption followed by a purchase. Therefore, an
exchange will be considered a taxable event for shareholders subject to tax.
Exchange transactions will be processed at the net asset value per share next
determined after receipt of the request. Shares of the portfolios may be
exchanged by mail or telephone. The telephone exchange privilege is automatic
and made available without shareholder election. The exchange privilege may be
modified or terminated by the Fund at any time upon 60-days notice to
shareholders.
 
    BY MAIL.  To exchange shares by mail, send a written exchange request to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798. Your written exchange request should include (i) the name, class of
shares and account number of your current Portfolio; (ii) the name(s) and
class(es) of shares of the portfolio(s) into which you intend to exchange
shares; and (iii) the signatures of all registered account holders.
 
    BY TELEPHONE.  To exchange shares by telephone, call the Fund at the phone
number provided on the cover of this Prospectus. A Fund representative will
request (i) the name, class of shares and account number of your current
Portfolio, and (ii) the name(s) and class(es) of shares of the portfolio(s) into
which you intend to exchange shares. For additional information regarding
responsibility for the authenticity of telephoned instructions, see "Redemption
of Shares" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by sending a written request to Morgan Stanley Institutional Fund, Inc.,
P.O. Box 2798, Boston, Massachusetts 02208-2798. It may not be possible to
transfer the registration of certain shares purchased through a Financial
Intermediary. As with redemptions, the written request must be received in "good
order" before any transfer can be made. Transferring the registration of shares
may affect the eligibility of your account for a given class of shares and may
result in involuntary conversion or redemption of your shares.
 
OTHER ACCOUNT INFORMATION
 
    The Fund does not issue share certificates for the Portfolio. All shares
purchased are confirmed to you and credited to your account on the Fund's books
maintained by the Adviser or its agents. You will have the same rights and
ownership with respect to such shares as if certificates had been issued.
 
EXCESSIVE TRADING
 
    Frequent trades in your account(s) can disrupt management of the Portfolio
and raise its expenses. Consequently, the Fund may, in its discretion and in the
interest of the Portfolio's shareholders and performance, bar a shareholder who
trades excessively from making further share purchases for an indefinite period.
The Fund considers excessive trading to be more than one purchase and sale
involving shares of the same class of a portfolio of the Fund within any 120-day
period. For example, the following series of transactions would amount to
excessive trading: exchanging shares of Portfolio A for shares of Portfolio B,
then exchanging shares of Portfolio B for shares of Portfolio C and then
exchanging shares of Portfolio C for shares of Portfolio A within a
 
                                       25
<PAGE>
120-day period. Two types of transactions are exempt from these excessive
trading restrictions: (i) trades exclusively between money market portfolios,
and (ii) trades made in connection with an asset allocation service managed or
advised by the Adviser and/or any of its affiliates.
 
INVESTMENT IN PORTFOLIOS BY OTHER INVESTMENT ACCOUNTS
 
    Morgan Stanley or its affiliates, including Morgan Stanley Asset Management
Inc., manage investment accounts for other clients, including other investment
companies, that invest in Class A or Class B shares of the portfolios. From time
to time, one or more of the portfolios used for investment by these accounts may
experience relatively large investments or redemptions due to investment
decisions made on behalf of these accounts. These transactions will affect the
portfolios, since portfolios that experience significant redemptions may have to
sell portfolio securities and portfolios that receive additional cash will have
to invest it in additional portfolio securities. It is impossible to predict the
overall impact of these transactions over time, however, there could be adverse
effects on portfolio management. These transactions also could have tax
consequences if sales of portfolio securities result in gains or could increase
transaction costs. The Adviser, representing the interests of the portfolios, is
committed to minimizing the impact of these transactions to the portfolios. The
Adviser, however, will have a conflict in fulfilling this responsibility in that
it also advises these investment accounts. The Adviser will monitor the impact
of these transactions on the portfolio.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of the Portfolio is
determined by dividing the total market value of the Portfolio's investments and
other assets attributable to such class, less any liabilities attributable to
such class, by the total number of outstanding shares of each class of the
Portfolio. Net asset value is calculated separately for each class of the
Portfolio. Net asset value per share is determined as of the close of the NYSE
(normally 4:00 p.m. Eastern Time) on each day that the NYSE is open for
business. Price information on listed securities is taken from the exchange
where the security is primarily traded. Securities listed on a U.S. securities
exchange for which market quotations are available are valued at the last quoted
sale price on the day the valuation is made. Securities listed on a foreign
exchange are valued at their closing price. Unlisted securities and listed
securities not traded on the valuation date and for which market quotations are
not readily available are valued at a price within a range not exceeding the
current asked price nor less than the current bid price. The current bid and
asked prices are determined based on the average of the bid and asked prices
quoted on such valuation date by reputable brokers.
 
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily. In addition, bonds and other fixed income securities may be
valued on the basis of prices provided by a pricing service when such prices are
believed to reflect the fair market value of such securities. The prices
provided by a pricing service are determined without regard to bid or last sale
prices, but take into account institutional size, trading in similar groups of
securities and any developments related to the specific securities. Securities
not priced in this manner are valued at the most recently quoted bid price or,
when securities exchange valuations are used, at the latest quoted sale price on
the day of valuation. If there is no such reported sale, the latest quoted bid
price will be used. Securities purchased with remaining maturities of 60 days or
less are valued at amortized cost, if it approximates market value. In the event
that amortized cost does not approximate market value, market prices as
determined above will be used.
 
                                       26
<PAGE>
    The value of other assets and securities for which quotations are not
readily available (including restricted and unlisted foreign securities) and
those securities for which it is inappropriate to determine prices in accordance
with the above-stated procedure are determined in good faith at fair value using
methods determined by the Board of Directors. For purposes of calculating net
asset value per share, all assets and liabilities initially expressed in foreign
currencies will be translated into U.S. dollars at the mean of the bid and asked
price of such currencies against the U.S. dollar last quoted by a major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distribution expense accrual differential among the classes. The
net asset value of Class B shares will generally be lower than the net asset
value of the Class A shares as a result of the distribution expense charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise total return for each class of the
Portfolio. THESE FIGURES ARE BASED ON HISTORICAL EARNINGS AND ARE NOT INTENDED
TO INDICATE FUTURE PERFORMANCE.
 
    "Total return" shows what an investment in a class of the Portfolio would
have earned over a specified period of time (such as one, five or ten years),
assuming that all distributions and dividends by the Portfolio were reinvested
in the same class on the reinvestment dates during the period. Total return does
not take into account any federal or state income taxes that may be payable on
dividends and distributions or on redemption. The Fund may also include
comparative performance information in advertising or marketing the Portfolio's
shares, including data from Lipper Analytical Services, Inc., other industry
publications, business periodicals, rating services and market indices.
 
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains distributions for a class of shares
will be automatically reinvested in additional shares of such class at net asset
value, except when, upon written notice to the Fund or by checking off the
appropriate box in the Distribution Option Section on the Account Registration
Form, a shareholder elects to receive income dividends and capital gains
distributions in cash.
 
    The Portfolio expects to distribute substantially all of its taxable net
investment income in the form of annual dividends. Net realized capital gains,
if any, after reduction for any available tax loss carryforwards will also be
distributed annually.
 
    Undistributed net investment income is included in the Portfolio's net
assets for the purpose of calculating net asset value per share. Therefore, on
the "ex-dividend" date, the net asset value per share excludes the dividend
(i.e., is reduced by the per share amount of the dividend). Dividends paid
shortly after the purchase of shares by an investor, although in effect a return
of capital, are taxable to shareholders subject to income tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
 
                                       27
<PAGE>
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of the Portfolio will differ at times.
Expenses of the Portfolio allocated to a particular class of shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of the Portfolio or its shareholders.
Accordingly, shareholders are urged to consult their tax advisers regarding
specific questions as to federal, state and local income taxes.
 
    The Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other portfolios. The Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Code, so that the Portfolio will be relieved
of federal income tax on that part of its net investment income and net capital
gain that is distributed to shareholders.
 
    The Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, net short-term capital gain) to
shareholders. Dividends from the Portfolio's net investment income are taxable
to shareholders as ordinary income, whether received in cash or reinvested in
additional shares. Such dividends paid by the Portfolio will generally not
qualify for the dividends-received deduction for corporate shareholders. The
Portfolio will report annually to its shareholders the amount of dividend income
qualifying for such treatment.
 
    Distributions of net capital gain are taxable to shareholders as a 20% rate
gain distribution (taxed at a rate of 20%) or a 28% rate gain distribution
(taxed at a rate of 28%), depending upon the designation by the Portfolio (such
designation being dependent upon the holding period of the Portfolio in the
underlying asset generating the net capital gain), regardless of how long the
shareholder has held the Portfolio's shares. The Portfolio will send reports
annually to shareholders of the federal income tax status of all distributions
made during the preceding year.
 
    The Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gain over short-term and long-term capital
losses, including any available capital loss carryforwards) prior to the end of
each calendar year to avoid liability for federal excise tax.
 
    Dividends and other distributions declared by the Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders in that year if the distributions are paid by the Portfolio at
any time during the following January.
 
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any dividends, capital gains distributions and redemption proceeds paid to any
individual or certain other non-corporate shareholder (i) who has failed to
provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Account Registration Form; (ii) who is subject to
 
                                       28
<PAGE>
backup withholding by the Internal Revenue Service; or (iii) who has not
certified to the Fund that such shareholder is not subject to backup
withholding. This backup withholding is not an additional tax, and any amounts
withheld may be credited against the shareholder's ultimate U.S. tax liability.
 
    The sale, exchange or redemption of shares will result in taxable gain or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the sale, exchange or redemption proceeds exceed or are
less than the shareholder's adjusted tax basis in the sold, exchanged or
redeemed shares. If capital gains distributions have been made with respect to
shares that are sold at a loss after being held for six months or less, then the
loss is treated as a long-term capital loss to the extent of the capital gains
distributions.
 
    Conversions of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisers concerning the
application of state and local income taxes to investments in the Portfolio,
which may differ from the federal income tax consequences described above.
 
    Investment income received by the Portfolio from sources within foreign
countries may be subject to foreign income taxes withheld at the source. To the
extent that the Portfolio is liable for foreign income taxes so withheld, the
Portfolio intends to operate so as to meet the requirements of the Code to pass
through to the shareholders credit for foreign income taxes paid. Although the
Portfolio intends to meet Code requirements to pass through credit for such
taxes, there can be no assurance that the Portfolio will be able to do so.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN THE PORTFOLIO.
 
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolio
for their clients.
 
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other remuneration paid to Morgan Stanley or other affiliates must be
fair and reasonable in comparison to those of
other broker-dealers for comparable transactions involving similar securities
being purchased or sold during a comparable time period.
 
                                       29
<PAGE>
PORTFOLIO TURNOVER
 
    The Portfolio generally does not invest for short-term trading purposes,
however, when circumstances warrant, the Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolio will not consider portfolio turnover rate a
limiting factor in making investment decisions consistent with its respective
objective and policies. Higher portfolio turnover (e.g., over 100%) necessarily
will cause the Portfolio to pay correspondingly increased brokerage and trading
costs. In addition to transaction costs, higher portfolio turnover may result in
the realization of capital gains. As discussed under "Taxes," to the extent net
short-term capital gains are realized, any distributions resulting from such
gains are considered ordinary income for federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 40 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of the
Portfolio are currently classified into two classes, the Class A shares and the
Class B shares.
 
    The shares of the Portfolio, when issued, will be fully paid, nonassessable,
fully transferable and redeemable at the option of the holder. The shares have
no preference as to conversion, exchange, dividends, retirement or other
features and have no pre-emptive rights. The shares of the Portfolio have
non-cumulative voting rights, which means that the holders of more than 50% of
the shares voting for the election of Directors can elect 100% of the Directors
if they choose to do so. Persons or organizations owning 25% or more of the
outstanding shares of the Portfolio may be presumed to "control" (as that term
is defined in the 1940 Act) the Portfolio. Under Maryland law, the Fund is not
required to hold an annual meeting of its shareholders unless required to do so
under the 1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual and semi-annual reports. The
financial statements appearing in annual reports are audited by independent
accountants. Monthly unaudited portfolio data is also available from the Fund
upon request.
 
    In addition, the Adviser or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
CUSTODIAN
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs
 
                                       30
<PAGE>
subcustodians approved by the Board of Directors of the Fund in accordance with
regulations of the Commission for the purpose of providing custodial services
for such assets. MSTC may also hold certain domestic assets for the Fund. For
more information on the custodians, see "General Information -- Custody
Arrangements" in the Statement of Additional Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits its annual financial statements.
 
FUND COUNSEL
 
    Morgan, Lewis & Bockius LLP acts as the Fund's legal counsel.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       31
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
  INTERNATIONAL MAGNUM PORTFOLIO
   P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                            <C>
      ACCOUNT INFORMATION                            If you need assistance in filling out this form for the Morgan Stanley
      Fill in where applicable                       Institutional Fund, Inc., please contact your Morgan Stanley
                                                     representative or call us toll free 1-800-548-7786. Please print all
                                                     items except signature, and mail to the Fund at the address above.
 
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
         TENANCY IN COMMON
         IS INDICATED)
</TABLE>
 
1.
         First Name    Initial         Last Name
 
2.
         First Name    Initial         Last Name
 
         First Name    Initial         Last Name
 
<TABLE>
<C>   <S>                                            <C>
      3. CORPORATIONS,
         TRUSTS AND OTHERS
         Please call the Fund for additional
      documents that may be required to set up
      account and to authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                     <C>                 <C>                   <C>               <C>
Type of Registration:   / / INCORPORATED    / / UNINCORPORATED    / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                            ASSOCIATION                               (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
 
<TABLE>
<C>   <S>                                            <C>
  B)  MAILING ADDRESS
      Please fill in completely, including
      telephone number(s).
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
 
/ / Non-Resident Alien
 
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
 
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
 
<TABLE>
<C>   <S>                                            <C>                                  <C>
  C)  TAXPAYER                                       Enter your Taxpayer Identification Number. For most individual
      IDENTIFICATION                                 taxpayers, this is your Social Security Number.
      NUMBER
      1. INDIVIDUAL
      2.   JOINT TENANTS
           (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
           TENANCY IN COMMON
           IS INDICATED)
      For Custodian account
      of a minor (Uniform
      Gifts/Transfers to Minor
      Acts), give the Social
      Security Number of
      the minor.
</TABLE>
<PAGE>
<TABLE>
<C>   <S>                                            <C>                                  <C>
                                                                                          OR
                                                     1.         TAXPAYER IDENTIFICATION                      SOCIAL SECURITY
                                                     NUMBER ("TIN")                                NUMBER ("SSN")
                                                                                              OR
                                                     2.                             TIN
                                                                                                                             SSN
                                                                                              OR
                                                     TIN
                                                                                                                             SSN
 
                                                     IMPORTANT TAX INFORMATION
                                                     You (as a payee) are required by law to provide us (as payer) with your
                                                     correct TIN(s) or SSN(s). Accounts that have a missing or incorrect
                                                     TIN(s) or SSN(s) will be subject to backup withholding at a 31% rate on
                                                     dividends, distributions and other payments. If you have not provided us
                                                     with your correct TIN(s) or SSN(s), you may be subject to a $50 penalty
                                                     imposed by the Internal Revenue Service.
                                                     Backup withholding is not an additional tax; the tax liability of
                                                     persons subject to backup withholding will be reduced by the amount of
                                                     tax withheld. If withholding results in an overpayment of taxes, a
                                                     refund may be obtained.
                                                     You may be notified that you are subject to backup withholding under
                                                     Section 3406(a)(1)(C) of the Internal Revenue Code because you have
                                                     underreported interest or dividends or you were required to, but failed
                                                     to, file a return which would have included a reportable interest or
                                                     dividend payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>                             <C>                   <C>
  D)  PORTFOLIO AND                        For Purchase of the following
      CLASS SECTION                        Portfolio:                      / / Class A Shares $  / / Class B Shares $
      (Class A shares minimum $500,000     International Magnum Portfolio
      for the Portfolio and Class B
      shares minimum $100,000 for the
      Portfolio). Please indicate class
      and amount.
                                                                           Total Initial Investment $
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate portfolio
      and manner of payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                          <C>
/ / Exchange $ From                                                                     -- - - - - - - - - - -- - -
                            Name of Portfolio                                                   Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on                 -- - - - - - - - - - -- - -
                                                                                      Account No.               (Check
                                                                                (Previously assigned by the Fund)     Digit)
                                                                                                                          Date
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  F)  DISTRIBUTION               Income dividends and capital gains distributions (if any) to
      OPTION                     be reinvested in additional shares unless either box below
                                 is checked.
                                 / / Income dividends to be paid in cash, capital gains
                                 distributions (if any) in shares.
                                 / / Income dividends and capital gains distributions (if
                                 any) to be paid in cash.
</TABLE>
 
<TABLE>
<C>   <S>                             <C>                                       <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone         Name of COMMERCIAL Bank (Not Savings
      AND EXCHANGE                    requests to wire redemption proceeds to   Bank)
      OPTION                          the commercial bank indicated at right    Bank Account No.
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund
      wish to redeem or exchange      account is registered if such requests                                        Bank
      shares by telephone. A          are believed to be authentic.                                                  ABA
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent                                         No.
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated    Name(s) in which your Bank Account is
      YOUR FUND ACCOUNT.              by telephone are genuine. These           Established
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal      Bank's Street
      NOT BE HONORED UNLESS THE BOX   identification information at the time    Address
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by   City  State  Zip
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  H)  INTERESTED PARTY
      OPTION                                                                                                Name
      In addition to the account
      statement sent to my/our registered
      address, I/we hereby authorize the                                                                   Address
      Fund to mail duplicate statements
      to the name and address provided at  City         State         Zip Code
      right.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  I)  DEALER
      INFORMATION
                                           Representative Name              Representative No.             Branch
                                           No.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here ,
</TABLE>
 
<TABLE>
<S>                                  <C>
The undersigned certify that I/we have full authority and legal capacity
to purchase and redeem shares of the Fund and affirm that I/we have
received a current Prospectus of the Morgan Stanley Institutional Fund,
Inc. and agree to be bound by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF
PERJURY THAT THE INFORMATION ON THIS APPLICATION IS COMPLETE AND CORRECT
AND THAT AS REQUIRED BY FEDERAL LAW (PLEASE CHECK APPLICABLE BOXES
BELOW):
 
/ / U.S. CITIZEN(S)/TAXPAYER(S):
 
      / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM
          IS/ARE THE CORRECT SSN(S) OR TIN(S) AND (2) I/WE ARE NOT
          SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE ARE
          EXEMPT FROM BACKUP WITHHOLDING; (B) I/WE HAVE NOT BEEN
          NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT I/WE ARE
          SUBJECT TO BACKUP WITHHOLDING AS A RESULT OF A FAILURE TO
          REPORT ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED
          ME/US THAT I AM/WE ARE NO LONGER SUBJECT TO BACKUP
          WITHHOLDING.
 
      / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE HAVE
          APPLIED, OR INTEND TO APPLY, TO THE IRS OR THE SOCIAL SECURITY
          ADMINISTRATION FOR A TIN OR A SSN AND I/WE UNDERSTAND THAT IF
          I/ WE DO NOT PROVIDE EITHER NUMBER TO CHASE GLOBAL FUNDS
          SERVICES COMPANY ("CGFSC") WITHIN 60 DAYS OF THE DATE OF THIS
          APPLICATION OR IF I/WE FAIL TO FURNISH MY/OUR CORRECT SSN(S)
          OR TIN(S), I/WE MAY BE SUBJECT TO A PENALTY AND A 31% BACKUP
          WITHHOLDING ON DISTRIBUTIONS AND REDEMPTION PROCEEDS. (PLEASE
          PROVIDE EITHER NUMBER ON IRS FORM W-9). YOU MAY REQUEST SUCH
          FORM BY CALLING CGFSC AT 800-282-4404.
 
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
  UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S.
CITIZENS OR RESIDENTS AND I/WE ARE EXEMPT FOREIGN PERSONS AS DEFINED BY
THE INTERNAL REVENUE SERVICE.
 
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY
PROVISION OF THIS DOCUMENT OTHER THAN THE CERTIFICATIONS REQUIRED TO
AVOID BACKUP WITHHOLDING.
 
                                     (X)
(X)                                  Signature (if joint account, both
Signature            Date            must sign)      Date
</TABLE>
<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<S>                                                 <C>
                                                    PAGE
                                                    ----
Fund Expenses.....................................    2
Financial Highlights..............................    4
Prospectus Summary................................    6
Investment Objective and Policies.................   10
Additional Investment Information.................   11
Investment Limitations............................   18
Management of the Fund............................   18
Purchase of Shares................................   20
Redemption of Shares..............................   23
Account Policies and Services.....................   24
Valuation of Shares...............................   26
Performance Information...........................   27
Dividends and Capital Gains Distributions.........   27
Taxes.............................................   28
Portfolio Transactions............................   29
General Information...............................   30
Account Registration Form
</TABLE>
 
                         INTERNATIONAL MAGNUM PORTFOLIO
 
                               A PORTFOLIO OF THE
 
                                 MORGAN STANLEY
 
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
 
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  Incorporated
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                      P.O. BOX 2798, BOSTON, MA 02208-2798
 
- ---------------------------------------
- ---------------------------------------
- ---------------------------------------
- ---------------------------------------
<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
     ----------------------------------------------------------------------
 
                              TECHNOLOGY PORTFOLIO
 
                               A PORTFOLIO OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
 
                                ----------------
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a series of diversified and nondiversified investment portfolios ("portfolios").
The Fund is designed to provide clients with attractive alternatives for meeting
their investment needs. The Fund currently consists of thirty-two portfolios
representing a broad range of investment choices. This prospectus (the
"Prospectus") pertains to the Class A and Class B shares of the Technology
Portfolio (the "Portfolio"). The Class A and Class B shares currently offered by
the Portfolio have different minimum investment requirements and fund expenses.
Shares of the Portfolio are offered with no sales charge, exchange fee or
redemption fee.
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator"), and with Morgan Stanley & Co. Incorporated ("Morgan Stanley")
as Distributor, the Fund makes available to institutional and high net worth
individual investors a series of portfolios which benefit from the investment
expertise and commitment to excellence associated with Morgan Stanley and its
affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under "Prospectus Summary" below. The Fund
currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging Markets,
European Equity, European Real Estate, Global Equity, International Equity,
International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) EQUITY AND FIXED INCOME -- Balanced
Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global
Fixed Income, High Yield and Municipal Bond Portfolios; and (v) MONEY MARKET --
Money Market and Municipal Money Market Portfolios. Additional information about
the Fund is contained in a "Statement of Additional Information," dated May 1,
1998, which is incorporated herein by reference. The Statement of Additional
Information and the prospectuses pertaining to the other portfolios of the Fund
are available upon request and without charge by writing or calling the Fund at
the address and telephone number set forth above.
 
  THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
   AND EXCHANGE COMMISSION, NOR HAS THE SECURITIES AND EXCHANGE COMMISSION
    PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS.     ANY
             REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
                  THE DATE OF THIS PROSPECTUS IS MAY 1, 1998.
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates all expenses and fees that a shareholder of
the Technology Portfolio will incur:
<TABLE>
<CAPTION>
SHAREHOLDER TRANSACTION EXPENSES
- --------------------------------------------------------------------------------------------
<S>                                                                                           <C>
Maximum Sales Load Imposed on Purchases
  Class A...................................................................................       None
  Class B...................................................................................       None
Maximum Sales Load Imposed on Reinvested Dividends
  Class A...................................................................................       None
  Class B...................................................................................       None
Deferred Sales Load
  Class A...................................................................................       None
  Class B...................................................................................       None
Redemption Fees
  Class A...................................................................................       None
  Class B...................................................................................       None
Exchange Fees
  Class A...................................................................................       None
  Class B...................................................................................       None
 
<CAPTION>
 
ANNUAL FUND OPERATING EXPENSES
 (AS A PERCENTAGE OF AVERAGE NET ASSETS)
- --------------------------------------------------------------------------------------------
<S>                                                                                           <C>
Management Fee (Net of Fee Waiver)*
  Class A...................................................................................      0.00%
  Class B...................................................................................      0.00%
12b-1 Fees
  Class A...................................................................................       None
  Class B...................................................................................      0.25%
Other Expenses
  Class A...................................................................................      1.25%
  Class B...................................................................................      1.25%
                                                                                              ---------
Total Operating Expenses (Net of Fee Waivers or Expense Reimbursements)*
  Class A...................................................................................      1.25%
  Class B...................................................................................      1.50%
                                                                                              ---------
                                                                                              ---------
</TABLE>
 
- --------------
 
*The Adviser has agreed to waive its management fees and/or reimburse the
 Portfolio, if necessary, if such fees would cause the total annual operating
 expenses of the Portfolio to exceed a specified percentage of its average daily
 net assets. Absent the fee waiver, the management fee would be 1.00%. Absent
 the fee waivers and/or expense reimbursements, the Portfolio's total operating
 expenses would be 2.47% of the average daily net assets of the Class A shares
 and 2.72% of the average daily net assets of the Class B shares. As a result of
 this reduction, the Management Fee stated above is lower than the contractual
 fee stated under "Management of the Fund." The Adviser reserves the right to
 terminate any of its fee waivers and/or expense reimbursements at any time in
 its sole discretion. For further information on Portfolio expenses, see
 "Management of the Fund."
 
                                       2
<PAGE>
    The purpose of the table above is to assist the investor in understanding
the various expenses that an investor in the Portfolio will bear directly or
indirectly. Expenses and fees for the Portfolio are based on actual figures for
the fiscal period ended December 31, 1997. Due to the continuous nature of Rule
12b-1 fees, long-term Class B shareholders may pay more than the equivalent of
the maximum front-end sales charges otherwise permitted by the National
Association of Securities Dealers, Inc. ("NASD") Conduct Rules.
 
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (i) a 5% annual rate of return, and (ii) redemption
at the end of each time period. As noted in the table above, the Portfolio
charges no redemption fees of any kind. The following example is based on the
total operating expenses of the Portfolio after fee waivers.
 
<TABLE>
<CAPTION>
                                                                       1 YEAR       3 YEARS      5 YEARS     10 YEARS
                                                                     -----------  -----------  -----------  -----------
<S>                                                                  <C>          <C>          <C>          <C>
Technology Portfolio
  Class A..........................................................   $      13    $      40    $      69    $     151
  Class B..........................................................          15           47           82          179
</TABLE>
 
- ------------------
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. THE PORTFOLIO IS NEW AND ACTUAL EXPENSES MAY BE GREATER
OR LESS THAN THOSE SHOWN.
 
                                       3
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following table provides financial highlights for the Class A and Class
B shares for the Technology Portfolio. The audited financial highlights for the
Portfolio's shares for the fiscal period ended December 31, 1997 are included in
the Fund's financial statements which appear in the Fund's December 31, 1997
Annual Report to Shareholders and which are incorporated by reference into the
Fund's Statement of Additional Information. The Portfolio's financial highlights
have been audited by Price Waterhouse LLP, whose unqualified report thereon is
also incorporated by reference into the Statement of Additional Information.
Additional information is included in the Annual Report. The Annual Report and
the financial statements therein, along with the Statement of Additional
Information, are available at no cost from the Fund at the address and telephone
number noted on the cover page of this Prospectus. The following information
should be read in conjunction with the financial statements and notes thereto.
 
                                       4
<PAGE>
                            THE TECHNOLOGY PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                 CLASS A                       CLASS B
                                                       ----------------------------  ----------------------------
                                                                       PERIOD FROM                   PERIOD FROM
                                                                      SEPTEMBER 16,                 SEPTEMBER 16,
                                                        YEAR ENDED      1996* TO      YEAR ENDED      1996* TO
                                                       DECEMBER 31,   DECEMBER 31,   DECEMBER 31,   DECEMBER 31,
                                                           1997           1996           1997           1996
                                                       -------------  -------------  -------------  -------------
<S>                                                    <C>            <C>            <C>            <C>
NET ASSET VALUE, BEGINNING OF PERIOD.................    $   10.71      $   10.00      $   10.71      $   10.00
                                                       -------------  -------------  -------------  -------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (Loss) (1)...................         0.07          (0.02)          0.04          (0.02)
  Net Realized and Unrealized Gain on Investments....         3.75           0.73           3.74           0.73
                                                       -------------  -------------  -------------  -------------
    Total from Investment Operations.................         3.82           0.71           3.78           0.71
                                                       -------------  -------------  -------------  -------------
DISTRIBUTIONS
  Net Investment Income..............................        (0.26)        --              (0.25)        --
  Net Realized Gain..................................        (1.28)        --              (1.28)        --
  In Excess of Net Realized Gain.....................        (1.00)        --              (1.00)        --
  Return of Capital..................................        (0.26)        --              (0.24)        --
                                                       -------------  -------------  -------------  -------------
    Total Distributions..............................        (2.80)        --              (2.77)        --
                                                       -------------  -------------  -------------  -------------
NET ASSET VALUE, END OF PERIOD.......................    $   11.73      $   10.71      $   11.72      $   10.71
                                                       -------------  -------------  -------------  -------------
                                                       -------------  -------------  -------------  -------------
TOTAL RETURN.........................................        37.27%          7.10%         36.90%          7.10%
                                                       -------------  -------------  -------------  -------------
                                                       -------------  -------------  -------------  -------------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)..............    $  31,788      $   3,595      $   2,394      $   1,487
  Ratio of Expenses to Average Net Assets (1)........         1.25%          1.25%**        1.50%          1.50%**
  Ratio of Net Investment Income (Loss) to Average
   Net Assets (1)....................................        (1.07)%        (0.70)%**       (1.41)%       (1.00)%**
  Portfolio Turnover Rate............................          622%            77%           622%            77%
  Average Commission Rate............................    $  0.0370      $  0.0374      $  0.0370      $  0.0374
- ------------------------
(1) Effect of voluntary expense limitation during the period:
     Per share benefit to net investment loss........        $0.08          $0.22          $0.04          $0.19
   Ratios before expense limitation:
     Expenses to Average Net Assets..................         2.47%          8.51%**        2.72%          9.14%**
     Net Investment Loss to Average Net Assets.......        (2.30)%        (7.96)%**       (2.63)%       (8.65)%**
</TABLE>
 
- --------------------------------------------------------------------------------
 
 * Commencement of operations
 
** Annualized
 
                                       5
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and high net worth individual investors a broad range of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates providing customized services as Adviser, Administrator and
Distributor. Each portfolio offers Class A shares and Class B shares, except for
the International Small Cap and Municipal Money Market Portfolios which offer
only Class A shares. Each portfolio has its own investment objective and
policies designed to meet its specific goals. This Prospectus pertains to the
Class A and Class B shares of the Technology Portfolio, the investment objective
of which is as follows:
 
    -The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of companies that, in the opinion of the
     Adviser, are expected to benefit from their involvement in technology and
     technology-related industries.
 
    The other portfolios of the Fund are described in other prospectuses which
may be obtained from the Fund at the address and phone number noted on the cover
of this Prospectus. The investment objectives of these other portfolios are
listed below.
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    -The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
     appreciation by investing in accordance with country weightings determined
     by the Adviser in equity securities of non-U.S. issuers which, in the
     aggregate, replicate broad country indices.
 
    -The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Asian issuers.
 
    -The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
     appreciation by investing primarily in equity securities of companies in
     the Asian real estate industry.
 
    -The CHINA GROWTH PORTFOLIO seeks to provide long-term capital appreciation
     by investing primarily in equity securities of issuers in The People's
     Republic of China, Hong Kong and Taiwan.
 
    -The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of emerging country issuers.
 
    -The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of European issuers.
 
    -The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income and
     long-term capital appreciation by investing primarily in equity securities
     in the European real estate industry.
 
    -The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers throughout the world,
     including U.S. issuers.
 
    -The GOLD PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of foreign and domestic issuers engaged in
     gold-related activities.
 
    -The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers.
 
    -The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers domiciled in
     EAFE countries.
 
                                       6
<PAGE>
    -The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
     by investing primarily in equity securities of non-U.S. issuers with equity
     market capitalizations of less than $1 billion.
 
    -The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Japanese issuers.
 
    -The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Latin American issuers and,
     from time to time, debt securities issued or guaranteed by Latin American
     governments or governmental entities.
 
    U.S. EQUITY:
 
    -The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by investing
     primarily in corporate equity and equity-linked securities.
 
    -The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing primarily in growth-oriented equity securities of small- to
     medium-sized corporations.
 
    -The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing in growth-oriented equity securities of medium and large
     capitalization companies.
 
    -The MICROCAP PORTFOLIO seeks long-term capital appreciation by investing
     primarily in growth-oriented equity securities of small corporations.
 
    -The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total return by
     investing in equity securities of small- to medium-sized companies which
     the Adviser believes to be undervalued.
 
    -The U.S. EQUITY PLUS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers included in the
     Standard & Poor's 500 Index ("S&P 500").
 
    -The U.S. REAL ESTATE PORTFOLIO seeks to provide above-average current
     income and long-term capital appreciation by investing primarily in equity
     securities of companies in the U.S. real estate industry, including
     substantial investment in real estate investment trusts.
 
    -The VALUE EQUITY PORTFOLIO seeks high total return by investing in equity
     securities which the Adviser believes to be undervalued relative to the
     stock market in general at the time of purchase.
 
    EQUITY AND FIXED INCOME:
 
    -The BALANCED PORTFOLIO seeks high total return while preserving capital by
     investing in a combination of equity securities which the Adviser believes
     to be undervalued and fixed income securities.
 
    FIXED INCOME:
 
    -The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by investing
     primarily in debt securities of government, government-related and
     corporate issuers located in emerging countries.
 
    -The FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
     with the preservation of capital by investing in a diversified portfolio of
     fixed income securities.
 
    -The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
     of return while preserving capital by investing in fixed income securities
     of issuers throughout the world, including U.S. issuers.
 
    -The HIGH YIELD PORTFOLIO seeks to maximize total return by investing in a
     diversified portfolio of high yield fixed income securities that offer a
     yield above that generally available on debt securities in the four highest
     rating categories of the recognized rating services.
 
                                       7
<PAGE>
    -The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a level
     of current income as is consistent with the preservation of capital by
     investing primarily in a variety of investment grade mortgage-backed
     securities.
 
    -The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of current
     income consistent with preservation of principal by investing in municipal
     obligations, the interest on which is exempt from federal income tax.
 
    MONEY MARKET:
 
    -The MONEY MARKET PORTFOLIO seeks to maximize current income and preserve
     capital while maintaining high levels of liquidity through investing in
     high quality money market instruments with remaining maturities of one year
     or less.
 
    -The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current tax-exempt
     income and preserve capital while maintaining high levels of liquidity
     through investing in high quality money market instruments with remaining
     maturities of one year or less which are exempt from federal income tax.
 
   THE CHINA GROWTH, GOLD, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS
   ARE CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley Dean Witter & Co., acts as investment adviser to the Fund and each of
its portfolios. As of March 31, 1998, Morgan Stanley Asset Management Inc. and
its affiliated institutional asset management companies managed assets of
approximately $166 billion, including assets under fiduciary advice. See
"Management of the Fund -- Investment Adviser" and "Management of the Fund --
Administrator."
 
HOW TO INVEST
 
    Class A shares of the Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of the
Portfolio are offered at net asset value with no sales commission, but with a
12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25% of the
Class B shares' average daily net assets on an annualized basis. The minimum
initial investment, generally, is $250,000 for Class A shares of the Portfolio
and $50,000 for Class B shares of the Portfolio. The minimum initial investment
amount is reduced for certain categories of investors. For additional
information on how to purchase shares and minimum initial investments, see
"Purchase of Shares."
 
HOW TO REDEEM
 
    Class A shares or Class B shares of the Portfolio may be redeemed at any
time, without cost, at the net asset value per share of the applicable class
next determined after receipt of the redemption request. The redemption price
may be more or less than the purchase price. Certain redemptions that cause the
value of an account to remain for a continuous 60-day period below the minimum
investment amount for Class A shares or for Class B shares may result in
involuntary redemption or automatic conversion. For additional information on
how to redeem shares and involuntary redemption or conversion, see "Purchase of
Shares" and "Redemption of Shares."
 
                                       8
<PAGE>
RISK FACTORS
 
    Investing in the Portfolio entails certain risks and considerations of which
an investor should be aware. The Portfolio's share price and investment returns
fluctuate and, when redeemed, an investment in the Portfolio may be worth more
or less than its original cost. The investment policies of the Portfolio may
entail the following risk factors:
 
    -EQUITY SECURITIES.  The Portfolio may invest in equity securities. Prices
     of equity securities fluctuate in response to many factors, including the
     financial health of the issuers and changes in economic and market
     conditions.
 
    -FIXED INCOME SECURITIES.  The Portfolio will be subject to credit risk and
     market risk associated with investment in fixed income securities. Credit
     risk is the possibility that an issuer may be unable to meet scheduled
     principal and interest payments. Market risk is the possibility that a
     change in interest rates or the market's perception of the issuer's
     prospects may adversely affect the value of a fixed income security.
 
    -HIGH YIELD SECURITIES.  The Portfolio may invest in lower rated and unrated
     fixed income securities (i.e., high yield or high risk securities), which
     are often issued by smaller or less creditworthy companies. High yield
     securities generally are subject to greater market risk and credit risk
     than other fixed income securities.
 
    -FOREIGN INVESTMENT.  The Portfolio may invest in the securities of foreign
     issuers. The risks of foreign investment include fluctuations in foreign
     currency values, political events affecting the country of issuance and
     potentially greater market volatility and lower liquidity.
 
    -EMERGING MARKET COUNTRY SECURITIES.  The Portfolio may invest in emerging
     market country securities which entail risks typically associated with
     investment in more established foreign markets. However, these risks may be
     intensified due to higher volatility and less liquidity of emerging
     markets, possible political risks associated with the country of issuance
     and generally weaker financial condition of issuers in these markets.
 
    -DERIVATIVES.  The Portfolio may invest in instruments that derive their
     values from those of specified securities, indices, currencies or other
     points of reference. These derivatives, including those used to manage
     risk, are themselves subject to the risks of the different markets in which
     they are traded and, therefore, may or may not serve their intended
     purposes.
 
    For additional information about risk factors, see also "Investment
Objectives and Policies" and "Additional Investment Information."
 
                                       9
<PAGE>
                       INVESTMENT OBJECTIVE AND POLICIES
 
    The investment objective of the Portfolio is to provide long-term capital
appreciation by investing primarily in equity securities of companies that, in
the opinion of the Adviser, are expected to benefit from their investment in
technology and technology-related industries. The production of current income
is incidental to this objective. Under normal circumstances, at least 65% of the
total assets of the Portfolio will be invested in the equity securities of such
"technology" companies. The Portfolio expects to invest in companies in a broad
range of technology and technology-related industries including, but not limited
to: computers, software and peripheral products; electronics; communications
equipment and services; entertainment; multimedia; and information services.
With respect to the Portfolio, equity securities include common and preferred
stocks, convertible securities, rights and warrants to purchase common stocks,
and any similar equity interests, such as trust or partnership interests. Such
equity securities may or may not pay dividends or distributions and may or may
not carry voting rights. The Portfolio's investment objective is a fundamental
policy which may not be changed without the approval of a majority of the
Portfolio's outstanding voting securities. There is no assurance that the
Portfolio will attain its objective. Other investment policies described below
are not fundamental policies unless otherwise noted and may be changed without
shareholder approval. In addition to the investments and strategies described
below, the Portfolio may invest in certain securities and obligations as set
forth in "Additional Investment Information" and as described under "Investment
Objectives and Policies" in the Statement of Additional Information.
 
    The Portfolio may invest up to 35% of its total assets in the equity or
fixed income securities of foreign issuers to permit the Portfolio to
participate sufficiently in the global technology market. The Portfolio's
investments in foreign issuers may be denominated in any currency and may be in
the form of Depositary Receipts or direct investment in listed or unlisted
securities.
 
    The Portfolio may invest in the equity securities of both large and small
companies. While the Adviser believes that smaller companies may provide greater
growth potential than larger, more established firms, investing in the
securities of smaller companies also involves greater risk and portfolio price
volatility. Among the reasons for this greater price volatility are the lower
degree of market liquidity (the securities of companies with small stock market
capitalizations may trade less frequently and in limited volume) and the greater
sensitivity of small companies to changing economic conditions.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    CONVERTIBLE SECURITIES, WARRANTS AND EQUITY-LINKED SECURITIES.  The
Portfolio may invest in securities such as convertible securities, preferred
stock, warrants or other securities exchangeable under certain circumstances for
shares of common stock. Warrants are instruments giving holders the right, but
not the obligation, to buy shares of a company at a given price during a
specified period.
 
    The Portfolio may invest in equity-linked securities, which are securities
that are convertible into, or the value of which is based upon the value of,
equity securities upon certain terms and conditions. The amount received by an
investor at maturity of such securities is not fixed but is based on the price
of the underlying common stock. It is impossible to predict whether the price of
the underlying common stock will rise or fall. Trading prices of the underlying
common stock will be influenced by the issuer's operational results, by complex,
interrelated political, economic, financial, or other factors affecting the
capital markets, the stock
 
                                       10
<PAGE>
exchanges on which the underlying common stock is traded and the market segment
of which the issuer is a part. In addition, it is not possible to predict how
equity-linked securities will trade in the secondary market, which is fairly
developed and liquid. The market for such securities may be shallow, however,
and high volume trades may be possible only with discounting. In addition to the
foregoing risks, the return on such securities depends on the creditworthiness
of the issuer of the securities, which may be the issuer of the underlying
securities or a third party investment bank or other lender. The
creditworthiness of such third party issuer of equity-linked securities may, and
often does, exceed the creditworthiness of the issuer of the underlying
securities. The advantage of using equity-linked securities over traditional
equity and debt securities is that the former are income producing vehicles that
may provide a higher income than the dividend income on the underlying equity
securities while allowing some participation in the capital appreciation of the
underlying equity securities. Another advantage of using equity-linked
securities is that they may be used for hedging to reduce the risk of investing
in the generally more volatile underlying equity securities.
 
    DEPOSITARY RECEIPTS.  The Portfolio may invest in Depositary Receipts,
including American Depositary Receipts ("ADRs"), Global Depositary Receipts
("GDRs"), European Depositary Receipts ("EDRs") and other Depositary Receipts
(which, together with ADRs, GDRs and EDRs, are hereinafter collectively referred
to as "Depositary Receipts"), to the extent that such Depositary Receipts are or
become available. ADRs are securities typically issued by a U.S. financial
institution (a "depositary"), that evidence ownership interests in a security or
pool of securities issued by a foreign issuer (the "underlying issuer") and
deposited with the depositary. ADRs may be "sponsored" or "unsponsored."
Sponsored ADRs are established jointly by a depositary and the underlying
issuer, whereas unsponsored ADRs may be established by a depositary without
participation by the underlying issuer. The issuers of the stock of unsponsored
ADRs are not obligated to disclose material information in the United States and
therefore, there may not be a correlation between such information and the
market value of the ADR. GDRs, EDRs and other types of Depositary Receipts are
typically issued by foreign depositaries, although they may also be issued by
U.S. depositaries, and evidence ownership interests in a security or pool of
securities issued by either a foreign or a U.S. corporation. Generally,
Depositary Receipts in registered form are designed for use in the U.S.
securities market and Depositary Receipts in bearer form are designed for use in
securities markets outside the United States. The Portfolio may invest in
sponsored and unsponsored Depositary Receipts. For purposes of the Portfolio's
investment policies, the Portfolio's investments in Depositary Receipts will be
deemed to be investments in the underlying securities.
 
    FIXED INCOME SECURITIES.  The Portfolio may invest in fixed income (debt)
securities. The market value of the fixed income securities in which the
Portfolio invests will be affected by changes in the creditworthiness of issuers
and will change in response to interest rate changes and other factors.
Generally, the values of fixed income securities vary inversely with changes in
interest rates, so that during periods of falling interest rates, the values of
outstanding fixed income securities generally rise and during periods of rising
interest rates, the values of such securities generally decline. While
securities with longer maturities tend to produce higher yields, the prices of
longer maturity securities are subject to greater market fluctuations as a
result of changes in interest rates.
 
    FOREIGN CURRENCY FORWARD CONTRACTS.  The Portfolio may enter into foreign
currency forward contracts ("forward contracts") that provide for the purchase
or sale of an amount of a specified currency at a future date. The Portfolio may
use such contracts to protect against a decline in a foreign currency against
the U.S. dollar between the trade date and settlement date when the Portfolio
purchases or sells securities, lock in the U.S.
 
                                       11
<PAGE>
dollar value of dividends and interest on securities held by the Portfolio, and
generally to protect the U.S. dollar value of securities held by the Portfolio
against exchange rate fluctuation. While forward contracts may limit losses as a
result of exchange rate fluctuations, they will also limit any gains that might
otherwise have been realized. The Portfolio's Custodian may be required to place
cash or liquid securities in a segregated account in an amount equal to the
value of the Portfolio's total assets committed to the consummation of forward
contracts. If the value of the securities placed in the segregated account
declines, additional cash or securities will be placed in the account on a daily
basis so that the value of the account will be at least equal to the amount of
the Portfolio's commitments with respect to such contracts.
 
    FOREIGN INVESTMENT.  The Portfolio may invest in the securities of foreign
issuers. Investment in securities of foreign issuers involves investment risks
somewhat different from those affecting securities of U.S. issuers. The
Portfolio's investments will be subject to political and economic events that
affect the countries in which it invests. Foreign issuers may be subject to
different accounting, auditing and financial standards and requirements. There
also may be less government supervision and regulation of foreign securities
exchanges, brokers and listed companies than in the United States. Many foreign
securities markets have substantially less trading volume than U.S. national
securities exchanges and, therefore, securities of some foreign issuers are less
liquid and more volatile than securities of comparable U.S. issuers. Brokerage
commissions and other transaction costs on foreign securities exchanges are
generally higher than in the United States. Dividends and interest paid by
foreign issuers may be subject to withholding and other foreign taxes, which may
decrease the net return on foreign investments as compared to dividends and
interest paid to the Portfolio by domestic companies. Investments in securities
of foreign issuers are generally denominated in foreign currencies and, since
the Portfolio may temporarily hold uninvested reserves in bank deposits in
foreign currencies, the value of the Portfolio's assets as measured in U.S.
dollars may be affected favorably or unfavorably by changes in currency exchange
rates and exchange control regulations, and the Portfolio may incur costs in
connection with conversions between various currencies.
 
    The Portfolio may also invest in emerging market country securities.
Investing in emerging markets entails the risks associated with foreign
investment described above, however, these risks may be intensified in emerging
markets. Emerging markets can include every nation in the world except the
United States, Canada, Japan, Australia, New Zealand and most nations located in
Western Europe. Certain emerging market countries have historically experienced,
and may continue to experience, high rates of inflation, high interest rates,
exchange rate fluctuations, large amounts of external debt, trade difficulties
and unemployment. Further, the economies of developing countries generally are
heavily dependent upon international trade and, accordingly, have been, and may
continue to be, adversely affected by trade barriers, exchange controls and
other protectionist measures imposed or negotiated by the countries in which
they trade. There also are risks associated with the possibility of
nationalization, expropriation or confiscatory taxation, political changes,
government regulation, social instability or diplomatic developments (including
war) that could adversely affect the economies of such countries or the value of
the Portfolio's investments in those countries.
 
    HIGH YIELD SECURITIES.  The Portfolio may invest in lower rated or unrated
debt securities, commonly referred to as high yield, high risk securities or
junk bonds. High yield securities are debt securities rated below the four
highest rating categories (i.e., Ba through C by Moody's Investors Service, Inc.
or BB through D by
 
                                       12
<PAGE>
Standard & Poor's Ratings Group ("S&P")), and unrated securities considered to
be of equivalent quality by the Adviser. Such securities carry a high degree of
risk and are considered speculative by the major credit rating agencies.
 
    While such securities offer high yields, they also normally carry with them
a greater degree of risk than securities with higher ratings. The values of high
yield securities are more volatile and may react with greater sensitivity to
market changes. Also, high yield securities are often issued by smaller, less
creditworthy companies, or by highly leveraged (indebted) companies, which are
generally less able than more established or less leveraged companies to make
scheduled payments of interest and principal. The price movement of these
securities is influenced less by changes in interest rates and more by the
financial position of the issuing corporation.
 
    INVESTMENT FUNDS.  Some foreign countries have laws and regulations that
currently preclude direct foreign investment in the securities of their
companies. However, indirect foreign investment in the securities of companies
listed and traded on the stock exchanges in these countries is permitted by
certain foreign countries through investment funds which have been specifically
authorized. The Portfolio may invest in these investment funds subject to the
provisions of the Investment Company Act of 1940, as amended (the "1940 Act"),
and other applicable laws. If the Portfolio invests in such investment funds,
the Portfolio's shareholders will bear not only their proportionate share of the
expenses of the Portfolio (including operating expenses and the fees of the
Adviser), but also will indirectly bear similar expenses of the underlying
investment funds. Certain of the investment funds are advised by the Adviser.
The Portfolio may, to the extent permitted under the 1940 Act and other
applicable law, invest in these investment funds.
 
    LOANS OF PORTFOLIO SECURITIES.  The Portfolio may lend its securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing net investment income. These loans must be secured
continuously by cash or equivalent collateral or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be risks of delay in recovery of the securities or even loss
of rights in the collateral should the borrower of the securities fail
financially. The Portfolio will not enter into securities loan transactions
exceeding, in the aggregate, 33 1/3% of the market value of the Portfolio's
total assets.
 
    MONEY MARKET INSTRUMENTS.  The Portfolio is permitted to invest in money
market instruments, although the Portfolio intends to stay invested in
securities satisfying its primary investment objective to the extent practical.
Consistent with its investment policies, the Portfolio may make money market
investments pending other investment or settlement for liquidity. In addition,
the Portfolio may invest in money market instruments for temporary defensive
purposes during adverse market conditions. The money market investments
permitted for the Portfolio include: obligations of the U.S. Government and its
agencies and instrumentalities, obligations of foreign sovereignties, commercial
paper, bank obligations (including certificates of deposit), other debt
securities and repurchase agreements.
 
    NON-PUBLICLY TRADED SECURITIES, PRIVATE PLACEMENTS AND RESTRICTED
SECURITIES.  The Portfolio may invest in securities that are neither listed on a
stock exchange nor traded over the counter. Such unlisted equity securities may
involve a higher degree of business and financial risk that can result in
substantial losses. As a result of the absence of a public trading market for
these securities, they may be less liquid than publicly traded securities.
Although these securities may be resold in privately negotiated transactions,
the prices realized from
 
                                       13
<PAGE>
these sales could be less than those originally paid by the Portfolio or less
than what may be considered the fair value of such securities. Further,
companies whose securities are not publicly traded may not be subject to the
disclosure and other investor protection requirements which might be applicable
if their securities were publicly traded. If such securities are required to be
registered under the securities laws of one or more jurisdictions before being
resold, the Portfolio may be required to bear the expenses of registration.
 
    As a general matter, the Portfolio may not invest more than 15% of its net
assets in illiquid securities, including securities for which there is no
readily available secondary market. Securities that are not registered under the
Securities Act of 1933, as amended, but that can be offered and sold to
qualified institutional buyers under Rule 144A under that Act ("Rule 144A
Securities") will not be included within the foregoing 15% restriction if the
securities are determined to be liquid. The Board of Directors has adopted
guidelines and delegated to the Adviser, subject to the supervision of the Board
of Directors, the daily function of determining and monitoring the liquidity of
Rule 144A securities. Rule 144A securities may become illiquid if qualified
institutional buyers are not interested in acquiring the securities. In
addition, the Portfolio may invest up to 10% of its total assets in restricted
securities, and up to 25% of its total assets in restricted securities that are
Rule 144A securities.
 
    REPURCHASE AGREEMENTS.  The Portfolio may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines established by
the Fund's Board of Directors. In a repurchase agreement, the Portfolio buys a
security from a seller that has agreed to repurchase it at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of the
agreement. The term of these agreements is usually from overnight to one week
and never exceeds one year. A repurchase agreement may be viewed as a fully
collateralized loan of money by the Portfolio to the seller. The Portfolio
always receives securities with a market value at least equal to the purchase
price (including accrued interest) as collateral, and this value is maintained
during the term of the agreement. If the seller defaults and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with respect to the seller, the Portfolio's realization upon the
collateral may be delayed or limited. The Portfolio may not enter into
repurchase agreements with more than seven days to maturity if, as a result,
more than 15% of the market value of the Portfolio's net assets are invested in
these agreements and other investments for which market quotations are not
readily available or which are otherwise illiquid.
 
    SHORT SALES.  The Portfolio may, and currently intends to, from time to
time, sell securities short without limitation, but consistent with applicable
legal requirements. A short sale is a transaction in which the Portfolio sells
securities it owns or has the right to acquire at no added cost (i.e., "against
the box") or does not own (but has borrowed) in anticipation of a decline in the
market price of the securities. To deliver the securities to the buyer, the
Portfolio arranges through a broker to borrow the securities and, in so doing,
the Portfolio becomes obligated to replace the securities borrowed at their
market price at the time of replacement. When the Portfolio makes a short sale
of borrowed securities, the proceeds it receives from the sale will be held on
behalf of a broker until the Portfolio replaces the borrowed securities. The
Portfolio may have to pay a premium to borrow the securities and must pay any
dividends or interest payable on the securities until they are replaced.
 
    The Portfolio's obligation to replace the securities borrowed in connection
with a short sale will be secured by collateral deposited with the broker that
consists of cash or other liquid securities. In addition, if the short sale is
not "against the box", the Portfolio will place in a segregated account with the
Custodian an amount of cash or other liquid securities equal to the difference,
if any, between (i) the market value of the securities sold at
 
                                       14
<PAGE>
the time they were sold short, and (ii) any cash or other liquid securities
deposited as collateral with the broker in connection with the short sale. Short
sales by the Portfolio involve certain risks and special considerations.
Possible losses from short sales differ from losses that could be incurred from
a purchase of a security, because losses from short sales may be unlimited,
whereas losses from purchases can equal only the total amount invested.
 
    TEMPORARY INVESTMENTS.  During periods in which the Adviser believes changes
in economic, financial or political conditions make it advisable, the Portfolio
may, for temporary defensive purposes, invest up to 100% of its total assets in
certain short-term and medium-term debt obligations or hold cash. The short-term
and medium-term debt obligations in which the Portfolio may invest consist of
(i) obligations of the U.S. or foreign governments, their respective agencies or
instrumentalities; (ii) money market instruments; and (iii) instruments
denominated in any currency issued by international development agencies.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  The Portfolio may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Delivery of and payment for these securities may take
as long as a month or more after the date of the purchase commitment but will
take place no more than 120 days after the trade date. The Portfolio will
maintain with the custodian a segregated account of cash or liquid securities in
an amount at least equal to these commitments. The payment obligation and the
interest rates that will be received are each fixed at the time the Portfolio
enters into the commitment and no interest accrues to the Portfolio until
settlement. Thus, it is possible that the market value at the time of settlement
could be higher or lower than the purchase price if, among other factors, the
general level of interest rates has changed. It is a current policy of the
Portfolio not to enter into when-issued commitments exceeding in the aggregate
15% of the market value of the Portfolio's total assets less liabilities, other
than the obligations created by these commitments.
 
DERIVATIVE PRODUCTS (DERIVATIVES)
 
    The Portfolio is permitted to utilize various exchange-traded and
over-the-counter derivative instruments and derivative securities, both for
hedging and non-hedging purposes. Permitted derivative products include, but are
not limited to: futures contracts ("futures"); forward contracts ("forwards");
options; swaps, caps, collars and floors; structured notes; and other derivative
products yet to be developed, so long as these new products are used in a manner
consistent with the objective of the Portfolio. These derivative products may be
based upon a wide variety of underlying rates, indices, instruments, securities
and other products, such as interest rates, foreign currencies, foreign and
domestic fixed income and equity securities, groups or "baskets" of securities
and securities indices (for each derivative product, the "underlying").
Exclusive of forward foreign currency contracts and any derivative products used
for hedging purposes, the Portfolio will limit its use of derivative products to
33 1/3% of its total assets, measured by the aggregate notional amount of
outstanding derivative products.
 
    The Portfolio may use derivative products under a number of different
circumstances to further its investment objective. For example, the Portfolio
may purchase derivatives to gain exposure to a market quickly in response to
changes in the Portfolio's investment strategy, upon the inflow of investable
cash or when the derivative provides greater liquidity than the underlying
market. The Portfolio may also use derivatives when it is restricted from
directly owning the "underlying" or when derivatives provide a pricing advantage
or lower
 
                                       15
<PAGE>
transaction costs. The Portfolio also may purchase combinations of derivatives
in order to gain exposure to an investment in lieu of actually purchasing such
investment. Derivatives may also be used by the Portfolio for hedging or risk
management purposes and in other circumstances when the Adviser believes it
advantageous to do so consistent with the Portfolio's investment objective and
policies. The Portfolio will not use derivatives in a manner that creates
leverage, except to the extent that the use of leverage is expressly permitted
by the Portfolio's investment policies, and then only in a manner consistent
with such policies.
 
    The use of derivative products is a highly specialized activity which
involves investment techniques and risks different from those associated with
ordinary portfolio securities transactions. If the Adviser is incorrect in
forecasts of market values, interest rates, and currency exchange rates, the
investment performance of the Portfolio will be less favorable than it would
have been if these investment techniques had not been used.
 
    Some of the derivative products in which the Portfolio may invest and some
of the risks related thereto are described in more detail below.
 
FUTURES CONTRACTS (FUTURES) AND FORWARD CONTRACTS (FORWARDS)
 
    The Portfolio may purchase and sell futures contracts, such as futures on
securities indices, baskets of securities, foreign currencies and interest rates
of the type generally known as financial futures. These are standardized
contracts that are bought and sold on organized exchanges. A futures contract
obligates a party to buy or sell a specific amount of the "underlying," such as
for example, a particular foreign currency, on a specified future date at a
specified price or to settle the value in cash.
 
    The Portfolio may also purchase and sell forward contracts, such as forward
rate agreements and other financial forward contracts. The Portfolio may also
use foreign currency forward contracts which are separately discussed elsewhere
in this Prospectus. See "Foreign Currency Forward Contracts" above. These
forward contracts are privately negotiated and are bought and sold in the
over-the-counter market. Like a future, a forward contract obligates a party to
buy or sell a specific amount of the underlying on a specified future date at a
specified price. The terms of the forward contract are customized. Forward
contracts, like other over-the-counter contracts that are negotiated directly
with an individual counterparty, subject the Portfolio to the risk of
counterparty default.
 
    In some cases, the Portfolio may be able to use either futures contracts,
forward contracts or exchange-traded or over-the-counter options to accomplish
similar purposes. In all cases, the Portfolio will use these products only as
permitted by applicable laws and regulations. Some of the ways in which the
Portfolio may utilize futures contracts, forward contracts and related options
are as follows:
 
    The Portfolio may sell securities index futures contracts and/or index
options thereon in anticipation of or during a market decline to attempt to
offset the decrease in market value of investments in its portfolio, or may
purchase securities index futures or options in order to gain market exposure.
There currently are limited securities index futures and options on such futures
in many countries, particularly emerging countries. The nature of the strategies
adopted by the Adviser, and the extent to which those strategies are used, may
depend on the development of such markets. The Portfolio may also purchase and
sell foreign currency futures to hedge its respective holdings and commitments
against changes in the level of future currency rates or to adjust its exposure
to a particular currency.
 
                                       16
<PAGE>
    The Portfolio may engage in transactions in interest rate futures and
related products. The value of these contracts rises and falls inversely with
changes in interest rates. The Portfolio may engage in such transactions to
hedge its holdings of debt instruments against future changes in interest rates
or for other purposes.
 
    The Portfolio may also purchase or sell futures and forwards on other
financial instruments, such as U.S. Government securities and certificates of
deposit. The value of these contracts also rises and falls inversely with
changes in interest rates. The Portfolio may engage in financial futures and
forward contracts for both hedging and non-hedging purposes.
 
    Gains and losses on futures contracts, forward contracts and related options
depend on the Adviser's ability to predict correctly the direction of securities
prices, interest rates and other economic factors. Other risks associated with
the use of these instruments include (i) imperfect correlation between the
change in market value of investments held by the Portfolio and the prices of
derivative products relating to investments purchased or sold by the Portfolio,
and (ii) possible lack of a liquid secondary market for a derivative product and
the resulting inability to close out a position. The risk that the Portfolio
will be unable to close out a position will be minimized by only entering into
transactions for which there appears to be a liquid exchange or secondary
market. In some strategies, the risk of loss in trading on futures and related
transactions can be substantial, due both to the low margin deposits required
and the extremely high degree of leverage involved in pricing.
 
    Under rules adopted by the Commodity Futures Trading Commission (the
"CFTC"), the Portfolio may, without registering with the CFTC as a Commodity
Pool Operator, enter into futures contracts and options thereon for both hedging
and non-hedging purposes, provided that not more than 5% of the Portfolio's
total assets at the time of entering the transaction are required as margin and
option premiums to secure obligations under such contracts relating to non-bona
fide hedging activities.
 
OPTION TRANSACTIONS
 
    The Portfolio may seek to increase its returns or may hedge its portfolio
investments through options transactions with respect to individual securities,
indices or baskets in which the Portfolio may invest; other financial
instruments; and foreign currency. Various options may be purchased and sold on
either the exchange-traded or over-the-counter markets.
 
    The Portfolio may purchase put and call options. Purchasing a put option
gives the Portfolio the right, but not the obligation, to sell the underlying
(such as a securities index or a particular foreign currency) at the exercise
price either on a specific date or during a specified exercise period.
Purchasing a call option gives the Portfolio a similar right, but not the
obligation, to purchase the underlying. The purchaser pays a premium to the
seller (also known as the writer) of the option.
 
    The Portfolio also may write put and call options on investments held in its
portfolio, as well as foreign currency options. The Portfolio that has written
an option receives a premium that increases the Portfolio's return on the
underlying in the event the option expires unexercised or is closed out at a
profit. However, by writing a call option, the Portfolio will limit its
opportunity to profit from an increase in the market value of the underlying
above the exercise price of the option. By writing a put option, the Portfolio
will be exposed to the amount by which the price of the underlying is less than
the strike price.
 
    By writing an option, the Portfolio incurs an obligation either to buy (in
the case of a put option) or sell (in the case of a call option) the underlying
from the purchaser of the option at the option's exercise price, upon
 
                                       17
<PAGE>
exercise by the purchaser. Pursuant to guidelines established by the Board of
Directors, the Portfolio may only write options that are "covered." A covered
call option means that until the expiration of the option, the Portfolio will
either earmark or segregate sufficient liquid assets to cover its obligations
under the option or will continue to own (i) the underlying; (ii) securities or
instruments convertible or exchangeable without the payment of any consideration
into the underlying; or (iii) a call option on the same underlying with a strike
price no higher than the price at which the underlying was sold pursuant to a
short option position. In the case of a put option, the Portfolio will either
earmark or segregate sufficient liquid assets to cover its obligations under the
option or will own another put option on the same underlying with an equal or
higher strike price.
 
    There currently are limited options markets in many countries, particularly
emerging market countries, and the nature of the strategies adopted by the
Adviser and the extent to which those strategies are used will depend on the
development of these options markets. The primary risks associated with the
Portfolio's use of options as described include (i) imperfect correlation
between the change in market value of investments held, purchased or sold by the
Portfolio and the prices of options relating to such investments, and (ii)
possible lack of a liquid secondary market for an option.
 
INTEREST RATE, CURRENCY, COMMODITY AND EQUITY SWAPS, CAPS, COLLARS AND FLOORS
 
    Swaps are privately negotiated over-the-counter derivative products in which
two parties agree to exchange payment streams calculated in relation to a rate,
index, instrument or certain securities and a particular "notional amount." As
with many of the other derivative products available to the Portfolio, the
underlying may include an interest rate (fixed or floating), a currency exchange
rate, a commodity price index, and a security, securities index or a combination
thereof. A great deal of flexibility is possible in the way the products may be
structured, with the effect being that the parties may have exchanged amounts
equal to the return on one rate, index or group of securities for another. For
example, in a simple fixed-to-floating interest rate swap, one party makes
payments equivalent to a fixed interest rate, and the other makes payments
equivalent to a specified interest rate index. The Portfolio may engage in
simple or more complex swap transactions involving a wide variety of
underlyings. The currency swaps that the Portfolio may enter will generally
involve an agreement to pay interest streams in one currency based on a
specified index in exchange for receiving interest streams denominated in
another currency. Such swaps may involve initial and final exchanges that
correspond to the agreed upon notional amount.
 
    Caps, collars and floors are privately-negotiated option-based derivative
products. The Portfolio may use one or more of these products in addition to or
in lieu of a swap involving a similar rate or index. As in the case of a put or
call option, the buyer of a cap or floor pays a premium to the writer. In
exchange for that premium, the buyer receives the right to a payment equal to
the differential if the specified index or rate rises above (in the case of a
cap) or falls below (in the case of a floor) a pre-determined strike level. As
in the case of swaps, obligations under caps and floors are calculated based
upon an agreed notional amount, and like most swaps (other than foreign currency
swaps), the entire notional amount is not exchanged and thus is not at risk. A
collar is a combination product in which the same party, such as the Portfolio,
buys a cap from and sells a floor to the other party. As with put and call
options, the amount at risk is limited for the buyer, but, if the cap or floor
is not hedged or covered, may be unlimited for the seller. Under current market
practice, caps, collars and floors between the same two parties are generally
documented under the same "master agreement." In some cases, options and forward
agreements may also be governed by the same master agreement. In the event of a
default, amounts owed under all transactions entered into under, or covered by,
the same master agreement would be netted and only a single payment would be
made.
 
                                       18
<PAGE>
    Swaps, caps, collars and floors are credit-intensive products. When the
Portfolio enters into a swap transaction it bears the risk of default, i.e.
nonpayment, by the other party. The guidelines under which the Portfolio enters
derivative transactions, along with some features of the transactions
themselves, are intended to reduce these risks to the extent reasonably
practicable, although they cannot eliminate the risks entirely. Under guidelines
established by the Board of Directors, the Portfolio may enter into swaps only
with parties that meet certain credit rating guidelines. Consistent with current
market practices, the Portfolio will generally enter into swap transactions on a
net basis, and all swap transactions with the same party will be documented
under a single master agreement to provide for net payment upon default. In
addition, the Portfolio's obligations under an agreement will be accrued daily
(offset against any amounts owing to the Portfolio) and any accrued, but unpaid,
net amounts owed to the other party to a master agreement will be covered by the
maintenance of a segregated account consisting of cash or liquid securities.
 
    Interest rate and total rate of return (fixed income or equity) swaps
generally do not involve the delivery of securities, other underlying assets, or
principal. In such case, if the other party to an interest rate or total rate of
return swap defaults, the Portfolio's risk of loss will consist of the payments
that the Portfolio is contractually entitled to receive from the other party.
This may not be true for currency swaps that require the delivery of the entire
notional amount of one designated currency in exchange for the other. If there
is a default by the other party, the Portfolio may have contractual remedies
pursuant to the agreements related to the transaction.
 
STRUCTURED NOTES
 
    Structured notes are derivative securities for which the amount of principal
repayment and/or interest payments is based upon the movement of one or more
factors. These factors include, but are not limited to, currency exchange rates,
interest rates (such as the prime lending rate and LIBOR) and stock indices,
such as the S&P 500. In some cases, the impact of the movements of these factors
may increase or decrease through the use of multipliers or deflators. The
Portfolio may use structured notes to tailor its investments to the specific
risks and returns the Adviser wishes to accept while avoiding or reducing
certain other risks.
 
                             INVESTMENT LIMITATIONS
 
    The Portfolio is a non-diversified portfolio under the 1940 Act, which means
that the Portfolio is not limited by the 1940 Act in the proportion of its
assets that may be invested in the obligations of a single issuer. Thus, the
Portfolio may invest a greater proportion of its assets in the securities of a
small number of issuers and as a result will be subject to greater risk with
respect to its portfolio securities. However, the Portfolio intends to comply
with diversification requirements imposed by the Internal Revenue Code of 1986,
as amended (the "Code"), for qualification as a regulated investment company.
See "Investment Limitations" in the Statement of Additional Information.
 
    The Portfolio also operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of the
holders of a majority of the Portfolio's outstanding shares and under certain
non-fundamental investment limitations that may be changed without shareholder
approval. For additional information on fundamental and non-fundamental
investment limitations, see "Investment Limitations" in the Statement of
Additional Information.
 
                                       19
<PAGE>
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and each Portfolio. The Adviser provides investment
advice and portfolio management services pursuant to an Investment Advisory
Agreement and, subject to the supervision of the Fund's Board of Directors,
makes each of the Portfolio's day-to-day investment decisions, arranges for the
execution of portfolio transactions and generally manages each of the
Portfolio's investments. The Adviser is entitled to receive from the Portfolio
an annual management fee, payable quarterly, equal to 1.00% of the average daily
net assets of the Portfolio. The Adviser has voluntarily agreed to a reduction
in the fees payable to it and to reimburse the Portfolio, if necessary, if such
fees would cause total annual operating expenses of the Portfolio to exceed
1.25% of the average daily net assets of the Class A shares of the Portfolio and
1.50% of the average daily net assets of the Class B shares of the Portfolio.
 
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to customers in the
United States and abroad. Morgan Stanley Dean Witter & Co. ("MSDW") is the
direct parent of the Adviser and Morgan Stanley. MSDW is a preeminent global
financial services firm that maintains leading market positions in each of its
three primary businesses--securities, asset management and credit services. At
March 31, 1998, the Adviser, together with its affiliated institutional asset
management companies, managed assets of approximately $166 billion, including
assets under fiduciary advice. See "Management of the Fund" in the Statement of
Additional Information.
 
    PORTFOLIO MANAGERS.  STEPHEN C. SEXAUER.  Stephen C. Sexauer is a Principal
of Morgan Stanley and the Adviser and is a member of the Adviser's investment
management team. In addition to portfolio management, his equity research
responsibilities include financials, energy, utilities and technology. Mr.
Sexauer joined the Adviser in July 1989 after three years as Vice President at
Salomon Brothers. Previously, he was with Merrill Lynch Economics and Wharton
Econometrics. Mr. Sexauer received a B.S. in Economics from the University of
Illinois and an M.B.A. in Economics and Statistics from the University of
Chicago.
 
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the officers and the
Board of Directors of the Fund and include day-to-day administration of matters
related to the corporate existence of the Fund, maintenance of its records,
preparation of reports, supervision of the Fund's arrangements with its
custodian and assistance in the preparation of the Fund's registration
statements under federal laws. The Administration Agreement also provides that
the Administrator, through its agents, will provide dividend disbursing and
transfer agent services to the Fund. For its services under the Administration
Agreement, the Fund pays the Adviser a monthly fee which on an annual basis
equals 0.15% of the average daily net assets of the Portfolio.
 
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors such administrative services provided by CGFSC.
Their services are also subject to the supervision of the Board of Directors of
the Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
                                       20
<PAGE>
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of the Portfolio upon the terms and at the current offering
price described in this Prospectus. Morgan Stanley is not obligated to sell any
certain number of shares of any Portfolio.
 
    The Portfolio currently offers only the classes of shares offered by this
Prospectus. The Portfolio may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares pursuant to Rule 12b-1 under the 1940 Act (the "Plan"). Under the Plan,
the Distributor is entitled to receive from the Portfolio a distribution fee,
which is accrued daily and paid quarterly, of 0.25% of the Class B shares'
average daily net assets on an annualized basis. Each Plan is designed to
compensate the Distributor for its services in connection with distribution
assistance. The Distributor may retain any portion of the fee that it does not
expend in meeting its obligations to the Fund. The Distributor may compensate
financial intermediaries, plan fiduciaries and administrators for providing
distribution-related services, including account maintenance services, to
shareholders (including, where applicable, underlying beneficial owners) of
Class B shares.
 
    EXPENSES.  The Portfolio is responsible for payment of certain other fees
and expenses (including legal fees, accountants' fees, custodial fees and
printing and mailing costs) as specified in its agreements with the Adviser and
Morgan Stanley.
 
    YEAR 2000.  The management and distribution services provided to the Fund by
the Adviser and Morgan Stanley depend on the smooth functioning of their
computer systems. Many computer software systems in use today cannot recognize
the year 2000, but revert to 1900 or some other date, due to the manner in which
dates were encoded and calculated. That failure could have a negative impact on
the handling of securities trades, pricing and account services. The Adviser and
Morgan Stanley have been actively working on necessary changes to their own
computer systems to deal with the year 2000 problem and expect that their
systems will be adapted before that date. There can be no assurance, however,
that they will be successful. In addition, other unaffiliated service providers
may be faced with similar problems. The Adviser and Morgan Stanley are
monitoring their remedial efforts, however, there can be no assurance that they
and the services they provide will not be adversely affected.
 
    In addition, it is possible that the markets for securities in which the
Portfolio invests may be detrimentally affected by computer failures throughout
the financial services industry beginning January 1, 2000. Improperly
functioning trading systems may result in settlement problems and liquidity
issues. In addition, corporate and governmental data processing errors may
result in production problems for individual companies and overall economic
uncertainties. Earnings of individual issuers will be affected by remediation
costs, which may be substantial and may be reported inconsistently in U.S. and
foreign financial statements. Accordingly, the Portfolio's investments may be
adversely affected.
 
                                       21
<PAGE>
                               PURCHASE OF SHARES
 
    Class A shares and Class B shares of the Portfolio may be purchased at the
net asset value per share next determined after receipt by the Fund of a
purchase order as described under "Methods of Purchase." The net asset value per
share of the Portfolio is calculated on days that the New York Stock Exchange
("NYSE") and Chase (the "Custodian Bank") are open for business as of the close
of trading of the NYSE, normally 4:00 p.m. Eastern Time (the "Pricing Time").
 
MINIMUM INVESTMENT
 
    The minimum initial investment is $250,000 for Class A shares and $50,000
for Class B shares of the Portfolio. These minimums may be waived at the
discretion of the Adviser for certain types of investors, including trust
departments, brokers, dealers, agents, financial planners, financial services
firms, investment advisers or various retirement and deferred compensation plans
("Financial Intermediaries"), certain accounts managed by the Adviser and its
affiliates ("Managed Accounts"), and certain employees and customers of Morgan
Stanley and its affiliates. The Fund's determination of an investor's
eligibility to purchase shares of a given class will take precedence over the
investor's selection of a class.
 
METHODS OF PURCHASE
 
    Shares may be purchased directly from the Fund by Federal Funds wire, by
bank wire or by check. Investors may also invest in the Portfolio by purchasing
shares through Financial Intermediaries that have made arrangements with Morgan
Stanley. Some Financial Intermediaries may charge an additional service or
transaction fee. If a purchase is canceled due to nonpayment or because your
check does not clear, you will be responsible for any loss the Fund or its
agents incur. If you are already a shareholder, the Fund may redeem shares from
your account(s) to reimburse the Fund or its agents for any loss. In addition,
you may be prohibited or restricted from making future investments in the Fund.
 
    FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire Federal
Funds to the Fund's bank account. Federal Funds purchase orders will be accepted
only on a day on which the Fund and the Custodian Bank are open for business.
Your bank may charge a service fee for wiring Federal Funds. In order to ensure
proper handling of your purchase by Federal Funds wire, please follow these
steps:
 
    1. Place your order by telephoning the Fund at 1-800-548-7786. A Fund
       representative will request certain purchase information and provide you
       with a confirmation number.
 
    2. Instruct your bank to wire the specified amount to the Fund's Wire
       Concentration Bank Account as follows:
 
       The Chase Manhattan Bank
       One Manhattan Plaza
       New York, NY 10081-1000
       ABA# 021000021
       DDA# 910-2-733293
       Attn: Morgan Stanley Institutional Fund, Inc.
       Ref: (Portfolio name, your account number, your account name)
 
       Please call the Fund at 1-800-548-7786 prior to wiring the funds.
 
                                       22
<PAGE>
    3. Complete and sign the Account Registration Form and mail it to the
       address shown thereon.
 
    When a purchase order is received prior to the Pricing Time and Federal
Funds are received prior to the close of the Federal Funds Wire Control Center
("FFWCC") (normally 6:00 p.m. Eastern Time), the purchase will be executed at
the net asset value computed on the date of receipt. Purchases for which an
order is received after the Pricing Time or for which Federal Funds are received
after the close of the FFWCC, will be executed at the net asset value next
determined. Certain institutional investors and financial institutions have
entered into an arrangement with Morgan Stanley, pursuant to which they may
place orders prior to the Pricing Time, but make payment in Federal Funds for
those shares on the following business day.
 
    BANK WIRE.  A purchase of shares by bank wire must follow the same procedure
as for a Federal Funds wire, described above. However, depending on the time the
bank wire is sent and which bank is handling the wire, money transferred by bank
wire may or may not be converted into Federal Funds prior to the close of the
FFWCC. Prior to conversion to Federal Funds and receipt by the Fund, an
investor's money will not be invested.
 
    CHECK.  An account may be opened by completing and signing an Account
Registration Form and mailing it, together with a check payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio name]" to:
 
    Morgan Stanley Institutional Fund, Inc.
    P.O. Box 2798
    Boston, Massachusetts 02208-2798
 
    The Fund ordinarily is credited with Federal Funds within one business day
of deposit of a check. Thus, a purchase of shares by check ordinarily will be
credited to your account at the net asset value per share determined on the next
business day after receipt. An investor's money will not be invested prior to
crediting of Federal Funds.
 
    INVESTMENT THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to receive purchase and
redemption orders from underlying beneficial owners, such as retirement plan
participants, generally on each business day. Each business evening, the
Financial Intermediary aggregates all orders received from underlying beneficial
owners prior to the Pricing Time on that business day and places a net purchase
and/or redemption order(s) by the morning of the next business day. These orders
normally are executed at the net asset value that was computed for the Portfolio
as of the close of the previous business day.
 
    ADDITIONAL INVESTMENTS.  You may purchase additional shares for your account
at any time by purchasing shares at net asset value by any of the methods
described above. The minimum additional investment generally is $1,000 for the
Portfolio. The minimum additional investment may be lower for certain accounts,
described above under "Minimum Investment." For purchases directly from the
Fund, your account name, the Portfolio name and the class selected must be
specified in the letter or wire to assure proper crediting to your account.
 
INVOLUNTARY CONVERSION AND REDEMPTION OF NEW ACCOUNT SHARES
 
    Class A and Class B shares of the Portfolio may be subject to the
involuntary conversion and redemption features described below. The conversion
and redemption features may be waived at the discretion of the Adviser for
shares held in a Managed Account and shares purchased through a Financial
Intermediary. Accounts
 
                                       23
<PAGE>
that were open prior to January 2, 1996 are not subject to involuntary
conversion or redemption. The Fund reserves the right to modify or terminate the
conversion or redemption features of the shares at any time upon 60 days notice
to shareholders.
 
    CONVERSION FROM CLASS A TO CLASS B SHARES.  If the value of an account
containing Class A shares falls below $250,000 (but remains at or above $50,000)
because of shareholder redemption(s), the Fund will notify the shareholder, and
if the account value remains below $250,000 (but remains at or above $50,000)
for a continuous 60-day period, the Class A shares in such account will convert
to Class B shares and will be subject to the distribution fee and other features
applicable to Class B shares. The Fund will not convert Class A shares to Class
B shares based solely upon changes in the market that reduce the net asset value
of shares. Under current tax law, conversion between share classes is not a
taxable event to the shareholder.
 
    CONVERSION FROM CLASS B TO CLASS A SHARES.  If the value of an account
containing Class B shares increases to $250,000 or more, whether due to
shareholder purchases or market activity, the Class B shares will convert to
Class A shares. Class B shares purchased through a Financial Intermediary that
has entered into an arrangement with the Fund for the purchase of such shares
may not be converted. Under current tax law, such conversion is not a taxable
event to the shareholder. Class A shares converted from Class B shares are
subject to the same minimum account size requirements as are applicable to New
Accounts containing Class A shares described above.
 
    INVOLUNTARY REDEMPTION OF SHARES.  If the value of an account falls below
$50,000 because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $50,000 for a continuous
60-day period, the shares in such account will be subject to redemption by the
Fund. The Fund will not redeem shares based solely upon changes in the market
that reduce the net asset value of shares. If redeemed, redemption proceeds will
be promptly paid to the shareholder.
 
                              REDEMPTION OF SHARES
 
    Class A and Class B shares of the Portfolio may be redeemed at any time and
without charge at the net asset value per share next determined after receipt by
the Fund of a redemption order as described under "Methods of Redemption."
Redemption proceeds may be more or less than the purchase price of your shares
depending on, among other factors, the market value of the investment securities
held by the Portfolio.
 
METHODS OF REDEMPTION
 
    Shares may be redeemed directly from the Fund by mail or by telephone.
However, shares purchased through a Financial Intermediary must be redeemed
through a Financial Intermediary. Certain Financial Intermediaries may charge an
additional service or transaction fee.
 
    BY MAIL.  The Portfolio will redeem shares upon receipt of a redemption
request in "good order." Redemption requests may be sent by regular mail to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798 or, by overnight courier, to Morgan Stanley Institutional Fund, Inc.,
c/o Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913.
 
    "Good order" means that the request to redeem shares must include the
following:
 
                                       24
<PAGE>
    1. A letter of instruction or a stock assignment specifying the class and
       number of shares or dollar amount to be redeemed, signed by all
registered owners of the shares in the exact names in which they are registered;
 
    2. Any required signature guarantees; and
 
    3. Other supporting legal documents, if required, in the case of estates,
       trusts, guardianships, custodianships, corporations, pension and
profit-sharing plans and other organizations.
 
    Redemption requests received in "good order" prior to the Pricing Time will
be executed at the net asset value computed on the date of receipt. Redemption
requests received after the Pricing Time will be executed at the next determined
net asset value. Shareholders who are uncertain of requirements for redemption
by mail should consult with a Fund representative.
 
    BY TELEPHONE.  If you have previously elected the Telephone Redemption
Option on the Account Registration Form, you can redeem Portfolio shares by
calling the Fund and requesting that the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. To change the commercial bank or account designated to receive
redemption proceeds, send a written request to the Fund at the address above.
Requests to change the bank or account must be signed by each shareholder and
each signature must be guaranteed. The telephone redemption option may be
difficult to implement at times, particularly during volatile market conditions.
If you experience difficulty in making a telephone redemption, you may redeem
shares by mail as described above.
 
    The Fund and the Transfer Agent will employ reasonable procedures to confirm
that instructions communicated by telephone are genuine. An investor may be
required to provide personal identification information at the time an account
is opened and prior to effecting each telephone transaction. In addition, all
telephone transaction requests will be recorded and investors may be required to
provide additional telecopied written instructions regarding transaction
requests. Neither the Fund nor the Transfer Agent will be responsible for any
loss, liability, cost or expense for following instructions received by
telephone that either of them reasonably believes to be genuine.
 
    REDEMPTION THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to accept redemption
requests from underlying beneficial owners. These redemptions may be processed
in the same way as purchases made through such Financial Intermediaries, as
described above.
 
FURTHER REDEMPTION INFORMATION
 
    The Fund normally makes payment for all shares redeemed within one business
day of receipt of the request, and in no event more than seven days after
receipt of a redemption request in good order. However, payments to investors
redeeming shares which were purchased by check will not be made until payment
for the purchase has been collected, which may take up to eight days after the
date of purchase. The Fund may suspend the right of redemption or postpone the
date upon which redemptions are effected at times when the NYSE is closed, or
under any emergency conditions as determined by the Securities and Exchange
Commission (the "Commission").
 
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of the Portfolio to make payment in
cash, the Fund may pay redemption proceeds in whole or in
 
                                       25
<PAGE>
part by a distribution-in-kind of readily marketable portfolio securities in
accordance with applicable rules of the Commission. Shareholders may incur
brokerage charges on the sale of portfolio securities received in payment of
redemptions.
 
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required to verify the identity of the person who has authorized
certain redemptions. Please contact the Fund or see the Statement of Additional
Information for further information.
 
                         ACCOUNT POLICIES AND SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares of the Portfolio that you own for shares of any
other available portfolio(s) of the Fund, subject to certain limitations. You
cannot exchange for shares of the International Equity, Emerging Markets, Small
Cap Value Equity, Balanced or Gold Portfolios because they are currently closed
to new investors. In addition, certain portfolios may be unavailable to
shareholders who purchased portfolio shares through a Financial Intermediary.
Contact your Financial Intermediary to determine which portfolios are available
for exchange.
 
    Before you make an exchange, you should read the prospectus of the
portfolio(s) in which you seek to invest. The class of shares you receive in the
exchange will be determined in the same manner as any other purchase of shares,
including minimum initial investment and account size requirements, and will not
be based on the class of shares you surrender for the exchange. Exchange
transactions are treated as a redemption followed by a purchase. Therefore, an
exchange will be considered a taxable event for shareholders subject to tax.
Exchange transactions will be processed at the net asset value per share next
determined after receipt of the request. Shares of the portfolios may be
exchanged by mail or telephone. The telephone exchange privilege is automatic
and made available without shareholder election. The exchange privilege may be
modified or terminated by the Fund at any time upon 60-days notice to
shareholders.
 
    BY MAIL.  To exchange shares by mail, send a written exchange request to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798. Your written exchange request should include (i) the name, class of
shares and account number of your current Portfolio; (ii) the name(s) and
class(es) of shares of the portfolio(s) into which you intend to exchange
shares; and (iii) the signatures of all registered account holders.
 
    BY TELEPHONE.  To exchange shares by telephone, call the Fund at the phone
number provided on the cover of this Prospectus. A Fund representative will
request (i) the name, class of shares and account number of your current
Portfolio, and (ii) the name(s) and class(es) of shares of the portfolio(s) into
which you intend to exchange shares. For additional information regarding
responsibility for the authenticity of telephoned instructions, see "Redemption
of Shares" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by sending a written request to Morgan Stanley Institutional Fund, Inc.,
P.O. Box 2798, Boston, Massachusetts 02208-2798. It may not be possible to
transfer the registration of certain shares purchased through a Financial
Intermediary. As with
 
                                       26
<PAGE>
redemptions, the written request must be received in "good order" before any
transfer can be made. Transferring the registration of shares may affect the
eligibility of your account for a given class of shares and may result in
involuntary conversion or redemption of your shares.
 
OTHER ACCOUNT INFORMATION
 
    The Fund does not issue share certificates for the Portfolio. All shares
purchased are confirmed to you and credited to your account on the Fund's books
maintained by the Adviser or its agents. You will have the same rights and
ownership with respect to such shares as if certificates had been issued.
 
EXCESSIVE TRADING
 
    Frequent trades in your account(s) can disrupt management of the Portfolio
and raise its expenses. Consequently, the Fund may, in its discretion and in the
interest of the Portfolio's shareholders and performance, bar a shareholder who
trades excessively from making further share purchases for an indefinite period.
The Fund considers excessive trading to be more than one purchase and sale
involving shares of the same class of a portfolio of the Fund within any 120-day
period. For example, the following series of transactions would amount to
excessive trading: exchanging shares of Portfolio A for shares of Portfolio B,
then exchanging shares of Portfolio B for shares of Portfolio C and then
exchanging shares of Portfolio C for shares of Portfolio A within a 120-day
period. Two types of transactions are exempt from these excessive trading
restrictions: (i) trades exclusively between money market portfolios, and (ii)
trades made in connection with an asset allocation service managed or advised by
the Adviser and/or any of its affiliates.
 
INVESTMENT IN PORTFOLIOS BY OTHER INVESTMENT ACCOUNTS
 
    Morgan Stanley or its affiliates, including Morgan Stanley Asset Management
Inc., manage investment accounts for other clients, including other investment
companies, that invest in Class A or Class B shares of the portfolios. From time
to time, one or more of the portfolios used for investment by these accounts may
experience relatively large investments or redemptions due to investment
decisions made on behalf of these accounts. These transactions will affect the
portfolios, since portfolios that experience significant redemptions may have to
sell portfolio securities and portfolios that receive additional cash will have
to invest it in additional portfolio securities. It is impossible to predict the
overall impact of these transactions over time, however, there could be adverse
effects on portfolio management. These transactions also could have tax
consequences if sales of portfolio securities result in gains or could increase
transaction costs. The Adviser, representing the interests of the portfolios, is
committed to minimizing the impact of these transactions to the portfolios. The
Adviser, however, will have a conflict in fulfilling this responsibility in that
it also advises these investment accounts. The Adviser will monitor the impact
of these transactions on the portfolio.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of the Portfolio is
determined by dividing the total market value of the Portfolio's investments and
other assets attributable to such class, less any liabilities attributable to
such class, by the total number of outstanding shares of such class of the
Portfolio. Net asset value is calculated separately for each class of the
Portfolio. Net asset value per share is determined as of the close of the NYSE
(normally 4:00 p.m. Eastern Time) on each day that the NYSE is open for
business. Price information on listed securities is taken from the exchange
where the security is primarily traded. Securities listed on a U.S. securities
exchange for which market quotations are available are valued at the last quoted
sale price on the day the
 
                                       27
<PAGE>
valuation is made. Securities listed on a foreign exchange are valued at their
closing price. Unlisted securities and listed securities not traded on the
valuation date and for which market quotations are not readily available are
valued at a price within a range not exceeding the current asked price nor less
than the current bid price. The current bid and asked prices are determined
based on the average of the bid and asked prices quoted on such valuation date
by reputable brokers.
 
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily. In addition, bonds and other fixed income securities may be
valued on the basis of prices provided by a pricing service when such prices are
believed to reflect the fair market value of such securities. The prices
provided by a pricing service are determined without regard to bid or last sale
prices but take into account institutional size trading in similar groups of
securities and any developments related to the specific securities. Securities
not priced in this manner are valued at the most recently quoted bid price or
when securities exchange valuations are used, at the latest quoted sale price on
the day of valuation. If there is no such reported sale, the latest quoted bid
price will be used. Securities purchased with remaining maturities of 60 days or
less are valued at amortized cost, if it approximates market value. In the event
that amortized cost does not approximate market value, market prices as
determined above will be used.
 
    The value of other assets and securities for which quotations are not
readily available (including restricted and unlisted foreign securities) and
those securities for which it is inappropriate to determine prices in accordance
with the above-stated procedure are determined in good faith at fair value using
methods determined by the Board of Directors. For purposes of calculating net
asset value per share, all assets and liabilities initially expressed in foreign
currencies will be translated into U.S. dollars at the mean of the bid and asked
price of such currencies against the U.S. dollar last quoted by a major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distribution expense accrual differential among the classes. The
net asset value of Class B shares will generally be lower than the net asset
value of the Class A shares as a result of the distribution expense charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise total return for each class of the
Portfolio. THESE FIGURES ARE BASED ON HISTORICAL EARNINGS AND ARE NOT INTENDED
TO INDICATE FUTURE PERFORMANCE.
 
    "Total return" shows what an investment in a class of the Portfolio would
have earned over a specified period of time (such as one, five or ten years),
assuming that all distributions and dividends by the Portfolio were reinvested
in the same class on the reinvestment dates during the period. Total return does
not take into account any federal or state income taxes that may be payable on
dividends and distributions or on redemption. The Fund may also include
comparative performance information in advertising or marketing the Portfolio's
shares, including data from Lipper Analytical Services, Inc., other industry
publications, business periodicals, rating services and market indices.
 
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                                       28
<PAGE>
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains distributions for a class of shares
will be automatically reinvested in additional shares at net asset value, except
when, upon written notice to the Fund or by checking off the appropriate box in
the Distribution Option Section on the Account Registration Form, a shareholder
elects to receive income dividends and capital gains distributions in cash.
 
    The Portfolio expects to distribute substantially all of its taxable net
investment income in the form of annual dividends. Net realized capital gains,
if any, after reduction for any available tax loss carryforwards will also be
distributed annually.
 
    Undistributed net investment income is included in the Portfolio's net
assets for the purpose of calculating net asset value per share. Therefore, on
the "ex-dividend" date, the net asset value per share excludes the dividend
(i.e., is reduced by the per share amount of the dividend). Dividends paid
shortly after the purchase of shares by an investor, although in effect a return
of capital, are taxable to shareholders subject to income tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of the Portfolio will differ at times.
Expenses of the Portfolio allocated to a particular class of shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of the Portfolio or its shareholders.
Accordingly, shareholders are urged to consult their tax advisers regarding
specific questions as to federal, state and local income taxes.
 
    The Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other portfolios. The Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Code, so that the Portfolio will be relieved
of federal income tax on that part of its net investment income and net capital
gain that is distributed to shareholders.
 
    The Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, the excess of net short-term
capital gain over net long-term capital loss) to shareholders. Dividends from
the Portfolio's net investment income are taxable to shareholders as ordinary
income, whether received in cash or in additional shares. Such dividends paid by
the Portfolio will generally qualify for the 70% dividends-received deduction
for corporate shareholders to the extent of qualifying dividend income received
by the Portfolio from U.S. corporations. The Portfolio will report annually to
its shareholders the amount of dividend income qualifying for such treatment.
 
    Distributions of net capital gains are taxable to shareholders as a 20% rate
gain distribution (taxed at a rate of 20%) or a 28% rate gain distribution
(taxed at a rate of 28%), depending upon the designation by the Portfolio (such
designation being dependent upon the holding period of the Portfolio in the
underlying asset generating
 
                                       29
<PAGE>
the net capital gain), regardless of how long the shareholder has held the
Portfolio's shares. The Portfolio will send reports annually to shareholders of
the federal income tax status of all distributions made during the preceding
year.
 
    The Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gain over short-term and long-term capital
loss, including any available capital loss carryforwards), prior to the end of
each calendar year to avoid liability for federal excise tax.
 
    Dividends and other distributions declared by the Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders in that year if the distributions are paid by the Portfolio at
any time during the following January.
 
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any dividends, capital gains distributions and redemption proceeds paid to any
individual or certain other non-corporate shareholder (i) who has failed to
provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Account Registration Form; (ii) who is subject to backup withholding by the
Internal Revenue Service; or (iii) who has not certified to the Fund that such
shareholder is not subject to backup withholding. This backup withholding is not
an additional tax, and any amounts withheld may be credited against the
shareholder's ultimate U.S. tax liability.
 
    The sale, redemption or exchange of shares will result in taxable gain or
loss to the selling, redeeming or exchanging shareholder, depending upon whether
the fair market value of the sale, redemption or exchange proceeds exceed or is
less than the shareholder's adjusted tax basis in the sold, redeemed or
exchanged shares. If capital gains distributions have been made with respect to
shares that are sold at a loss after being held for six months or less, then the
loss is treated as a long-term capital loss to the extent of the capital gains
distributions.
 
    Conversions of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisers concerning the
application of state and local income taxes to investments in the Portfolio,
which may differ from the federal income tax consequences described above.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN THE PORTFOLIO.
 
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
                                       30
<PAGE>
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolio
for their clients.
 
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other remuneration paid to Morgan Stanley or other affiliates must be
fair and reasonable in comparison to those of other broker-dealers for
comparable transactions involving similar securities being purchased or sold
during a comparable time period.
 
PORTFOLIO TURNOVER
 
    The Portfolio generally does not invest for short-term trading purposes,
however, when circumstances warrant, the Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolio will not consider portfolio turnover rate a
limiting factor in making investment decisions consistent with their respective
objective and policies. For the fiscal year ended December 31, 1997, the
Technology Portfolio had a portfolio turnover rate of 622%. Higher portfolio
turnover (e.g., over 100%) necessarily will cause the Portfolio to pay
correspondingly increased brokerage and trading costs. In addition to
transaction costs, higher portfolio turnover may result in the realization of
capital gains. As discussed under "Taxes," to the extent net short-term capital
gains are realized, any distributions resulting from such gains are considered
ordinary income for federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 40 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of the
Portfolio are currently classified into two classes, the Class A shares and the
Class B shares.
 
    The shares of the Portfolio, when issued, will be fully paid, nonassessable,
fully transferable and redeemable at the option of the holder. The shares have
no preference as to conversion, exchange, dividends, retirement or other
features and have no pre-emptive rights. The shares of the Portfolio have
non-cumulative voting rights, which means that the holders of more than 50% of
the shares voting for the election of Directors can elect 100% of the Directors
if they choose to do so. Persons or organizations owning 25% or more of the
outstanding shares of the Portfolio may be presumed to "control" (as that term
is defined in the 1940 Act) the Portfolio. Under Maryland law, the Fund is not
required to hold an annual meeting of its shareholders unless required to do so
under the 1940 Act.
 
                                       31
<PAGE>
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual and semi-annual reports. The
financial statements appearing in annual reports are audited by independent
accountants. Monthly unaudited portfolio data is also available from the Fund
upon request.
 
    In addition, the Adviser or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
CUSTODIAN
 
    Chase is the Fund's Custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs subcustodians approved by the Board of Directors of the Fund
in accordance with regulations of the Commission for the purpose of providing
custodial services for such assets. MSTC may also hold certain domestic assets
for the Fund. For more information on the custodians, see "General Information
- -- Custody Arrangements" in the Statement of Additional Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits its annual financial statements.
 
FUND COUNSEL
 
    Morgan, Lewis & Bockius LLP acts as the Fund's legal counsel.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       32
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
          TECHNOLOGY PORTFOLIO
           P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                             <C>
                                      If you need assistance in filling out this form for the
      ACCOUNT INFORMATION             Morgan Stanley Institutional Fund, Inc., please contact your
      Fill in where applicable        Morgan Stanley representative or call us toll free
                                      1-800-548-7786. Please print all items except signature, and
                                      mail to the Fund at the address above.
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP
      PRESUMED UNLESS
         TENANCY IN COMMON
         IS INDICATED)
</TABLE>
 
1.
First Name                          Initial      Last Name
2.
First Name                          Initial      Last Name
First Name                          Initial      Last Name
 
<TABLE>
<C>   <S>                        <C>
      3. CORPORATIONS,
         TRUSTS AND OTHERS
         Please call the Fund
      for additional documents
      that may be required to
      set up account and to
      authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                     <C>                 <C>                   <C>               <C>
Type of Registration:   / / INCORPORATED    / / UNINCORPORATED    / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                            ASSOCIATION                               (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
 
<TABLE>
<C>   <S>                        <C>
  B)  MAILING ADDRESS
      Please fill in
      completely, including
      telephone number(s).
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
/ / Non-Resident Alien
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
 
<TABLE>
<C>   <S>                        <C>         <C>                             <C>         <C>
  C)  TAXPAYER                   Enter your Taxpayer Identification Number. For most individual taxpayers, this is your
      IDENTIFICATION             Social Security Number.
      NUMBER
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF
      SURVIVORSHIP PRESUMED
      UNLESS
         TENANCY IN COMMON
         IS INDICATED)
      For Custodian account
      of a minor (Uniform
      Gifts/Transfers to Minor
      Acts), give the Social
      Security Number of
      the minor.
                                 1.          TAXPAYER IDENTIFICATION NUMBER              SOCIAL SECURITY NUMBER ("SSN")
                                                        ("TIN")
                                                                                 OR
                                 2.                       TIN                                         SSN
                                                                                 OR
                                                          TIN                                         SSN
                                                                                 OR
                                 IMPORTANT TAX INFORMATION
                                 You (as a payee) are required by law to provide us (as payer) with your correct TIN(s)
                                 or SSN(s). Accounts that have a missing or incorrect TIN(s) or SSN(s) will be subject
                                 to backup withholding at a 31% rate on dividends, distributions and other payments. If
                                 you have not provided us with your correct TIN(s) or SSN(s), you may be subject to a
                                 $50 penalty imposed by the Internal Revenue Service.
                                 Backup withholding is not an additional tax; the tax liability of persons subject to
                                 backup withholding will be reduced by the amount of tax withheld. If withholding
                                 results in an overpayment of taxes, a refund may be obtained.
                                 You may be notified that you are subject to backup withholding under Section
                                 3406(a)(1)(C) of the Internal Revenue Code because you have underreported interest or
                                 dividends or you were required to, but failed to, file a return which would have
                                 included a reportable interest or dividend payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                        <C>                             <C>
  D)  PORTFOLIO AND              For Purchase of the following
      CLASS SECTION              Portfolio:                      / / Class A Shares $ / / Class B
      (Class A shares minimum    Technology Portfolio            Shares $
      $250,000 for the                                           Total Initial Investment $
      Portfolio and Class B
      shares minimum $50,000
      for the Portfolio).
      Please indicate class and
      amount.
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate portfolio
      and manner of payment.
</TABLE>
 
Payment by:
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                    <C>
/ / Exchange $ From                                                                   - - - - - - - - - - - -- - -
                                                      Name of
Portfolio                                                                                      Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire
on                                                                                     -- - - - - - - - - - -- - -
                                                                                    Account No.               (Check
                                                                              (Previously assigned by the Fund)     Digit)
                                                                            Date
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  F)  DISTRIBUTION               Income dividends and capital gains distributions (if any) to
      OPTION                     be reinvested in additional shares unless either box below
                                 is checked.
                                 / / Income dividends to be paid in cash, capital gains
                                 distributions (if any) in shares.
                                 / / Income dividends and capital gains distributions (if
                                 any) to be paid in cash.
</TABLE>
 
<TABLE>
<C>   <S>                             <C>                                       <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone         Name of COMMERCIAL Bank (Not Savings
      AND EXCHANGE                    requests to wire redemption proceeds to   Bank)
      OPTION                          the commercial bank indicated at right    Bank Account No.
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund     Bank ABA No.
      wish to redeem or exchange      account is registered if such requests
      shares by telephone. A          are believed to be authentic.             Name(s) in which your Bank Account is
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent    Established
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated    Bank's Street
      YOUR FUND ACCOUNT.              by telephone are genuine. These           Address
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal      City  State  Zip
      NOT BE HONORED UNLESS THE BOX   identification information at the time
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  H)  INTERESTED PARTY
      OPTION                                                                                      Name
      In addition to the
      account statement sent to
      my/our registered                                                                          Address
      address, I/we hereby
      authorize the Fund to      City         State         Zip Code
      mail duplicate statements
      to the name and address
      provided at right.
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  I)  DEALER
      INFORMATION
                                 Representative Name   Representative No.   Branch No.
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here ,
</TABLE>
 
<TABLE>
<S>                                  <C>
The undersigned certify that I/we have full authority and legal capacity to purchase
and redeem shares of the Fund and affirm that I/we have received a current Prospectus
of the Morgan Stanley Institutional Fund, Inc. and agree to be bound by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF PERJURY THAT THE
INFORMATION ON THIS APPLICATION IS COMPLETE AND CORRECT AND THAT AS REQUIRED BY FEDERAL
LAW (PLEASE CHECK APPLICABLE BOXES BELOW):
/ / U.S. CITIZEN(S)/TAXPAYER(S):
       / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM IS/ARE THE
           CORRECT SSN(S) OR TIN(S) AND (2) I/WE ARE NOT SUBJECT TO ANY BACKUP
           WITHHOLDING EITHER BECAUSE (A) I/WE ARE EXEMPT FROM BACKUP WITHHOLDING; (B)
           I/WE HAVE NOT BEEN NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT
           I/WE ARE SUBJECT TO BACKUP WITHHOLDING AS A RESULT OF A FAILURE TO REPORT
           ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED ME/US THAT I AM/WE
           ARE NO LONGER SUBJECT TO BACKUP WITHHOLDING.
       / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE HAVE APPLIED, OR
           INTEND TO APPLY, TO THE IRS OR THE SOCIAL SECURITY ADMINISTRATION FOR A TIN
           OR A SSN AND I/WE UNDERSTAND THAT IF I/WE DO NOT PROVIDE EITHER NUMBER TO
           CHASE GLOBAL FUNDS SERVICES COMPANY ("CGFSC") WITHIN 60 DAYS OF THE DATE OF
           THIS APPLICATION OR IF I/WE FAIL TO FURNISH MY/OUR CORRECT SSN(S) OR TIN(S),
           I/WE MAY BE SUBJECT TO A PENALTY AND A 31% BACKUP WITHHOLDING ON
           DISTRIBUTIONS AND REDEMPTION PROCEEDS. (PLEASE PROVIDE EITHER NUMBER ON IRS
           FORM W-9). YOU MAY REQUEST SUCH FORM BY CALLING CGFSC AT 800-282-4404.
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
  UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S. CITIZENS OR RESIDENTS
AND I/WE ARE EXEMPT FOREIGN PERSONS AS DEFINED BY THE INTERNAL REVENUE SERVICE.
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY PROVISION OF THIS
DOCUMENT OTHER THAN THE CERTIFICATIONS REQUIRED TO AVOID BACKUP WITHHOLDING.
                                     (X)
(X)                                  Signature (if joint account, both must
Signature                                                         Date sign)                       Date
</TABLE>
<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<S>                                                 <C>
                                                    PAGE
                                                    ----
Fund Expenses.....................................    2
Financial Highlights..............................    4
Prospectus Summary................................    6
Investment Objective and Policies.................   10
Additional Investment Information.................   10
Investment Limitations............................   19
Management of the Fund............................   20
Purchase of Shares................................   22
Redemption of Shares..............................   24
Account Policies and Services.....................   26
Valuation of Shares...............................   27
Performance Information...........................   28
Dividends and Capital Gains Distributions.........   29
Taxes.............................................   29
Portfolio Transactions............................   30
General Information...............................   31
Account Registration Form
</TABLE>
 
                              TECHNOLOGY PORTFOLIO
 
                               A PORTFOLIO OF THE
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
 
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  INCORPORATED
 
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                      P.O. BOX 2798, BOSTON, MA 02208-2798
 
- ---------------------------------------
- ---------------------------------------
- ---------------------------------------
- ---------------------------------------
<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
- --------------------------------------------------------------------------------
 
                             ASIAN EQUITY PORTFOLIO
                           JAPANESE EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
 
                                ----------------
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a series of diversified and non-diversified investment portfolios
("portfolios"). The Fund is designed to provide clients with attractive
alternatives for meeting their investment needs. The Fund currently consists of
thirty-two portfolios representing a broad range of investment choices. This
prospectus (the "Prospectus") pertains to the Class A and the Class B shares of
the Asian Equity and Japanese Equity Portfolios (each, a "Portfolio" and
collectively, the "Portfolios"). The Class A and Class B shares currently
offered by the Portfolios have different minimum investment requirements and
fund expenses. Shares of the Portfolios are offered with no sales charge,
exchange fee or redemption fee.
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator"), and with Morgan Stanley as Distributor, the Fund makes
available to institutional and high net worth individual investors a series of
portfolios which benefit from the investment expertise and commitment to
excellence associated with Morgan Stanley and its affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under "Prospectus Summary" below. The Fund
currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging Markets,
European Equity, European Real Estate, Global Equity, International Equity,
International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) EQUITY AND FIXED INCOME -- Balanced
Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global
Fixed Income, High Yield and Municipal Bond Portfolios; and (v) MONEY MARKET --
Money Market and Municipal Money Market Portfolios. Additional information about
the Fund is contained in a "Statement of Additional Information," dated May 1,
1998, which is incorporated herein by reference. The Statement of Additional
Information and the prospectuses pertaining to the other portfolios of the Fund
are available upon request and without charge by writing or calling the Fund at
the address and telephone number set forth above.
 
 THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
   EXCHANGE COMMISSION, NOR HAS THE SECURITIES AND EXCHANGE COMMISSION
    PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY
             REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
                   THE DATE OF THIS PROSPECTUS IS MAY 1, 1998
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates the expenses and fees that a shareholder of
each Portfolio listed below will incur.
 
<TABLE>
<CAPTION>
                                                                                       ASIAN EQUITY   JAPANESE EQUITY
SHAREHOLDER TRANSACTION EXPENSES                                                         PORTFOLIO       PORTFOLIO
- -------------------------------------------------------------------------------------  -------------  ---------------
<S>                                                                                    <C>            <C>
Maximum Sales Load Imposed on Purchases
  Class A............................................................................         None            None
  Class B............................................................................         None            None
Maximum Sales Load Imposed on Reinvested Dividends
  Class A............................................................................         None            None
  Class B............................................................................         None            None
Deferred Sales Load
  Class A............................................................................         None            None
  Class B............................................................................         None            None
Redemption Fees
  Class A............................................................................         None            None
  Class B............................................................................         None            None
Exchange Fees
  Class A............................................................................         None            None
  Class B............................................................................         None            None
</TABLE>
 
<TABLE>
<CAPTION>
                                                                                ASIAN
ANNUAL FUND OPERATING EXPENSES                                                 EQUITY     JAPANESE EQUITY
 (AS A PERCENTAGE OF AVERAGE NET ASSETS)                                      PORTFOLIO      PORTFOLIO
- ---------------------------------------------------------------------------  -----------  ---------------
Management Fee (Net of Fee Waivers)*
<S>                                                                          <C>          <C>
  Class A..................................................................       0.61%          0.72%
  Class B..................................................................       0.61%          0.72%
12b-1 Fees
  Class A..................................................................        None           None
  Class B..................................................................       0.25%          0.25%
Other Expenses
  Class A..................................................................       0.39%**        0.28%
  Class B..................................................................       0.39%**        0.28%
                                                                             -----------       -------
Total Operating Expenses (Net of Fee Waivers)*
  Class A..................................................................       1.00%          1.00%
  Class B..................................................................       1.25%          1.25%
                                                                             -----------       -------
                                                                             -----------       -------
</TABLE>
 
 * The Adviser has agreed to waive its management fees and/or reimburse the
   Portfolios, if necessary, if such fees would cause the total annual operating
   expenses of each of the Portfolios to exceed a specified percentage of its
   respective average daily net assets. As a result of these reductions, the
   Management Fees stated above are lower than the contractual fees stated under
   "Management of the Fund." The Adviser reserves the right to terminate any of
   its fee waivers and/or expense reimbursements at any time in its sole
   discretion. For further information on Fund expenses, see "Management of the
   Fund." Set forth below, for each Portfolio, as applicable, are the management
   fees and total operating expenses absent such fee waivers and/or expense
   reimbursements as a percentage of average daily net assets of the Class A and
   Class B shares of the Portfolios.
 
<TABLE>
<CAPTION>
                                                                                           TOTAL
                                                                                     OPERATING EXPENSES
                                                                                           ABSENT
                                                                  MANAGEMENT            FEE WAIVERS
                                                                FEES ABSENT FEE  --------------------------
PORTFOLIO                                                           WAIVERS        CLASS A       CLASS B
- --------------------------------------------------------------  ---------------  ------------  ------------
<S>                                                             <C>              <C>           <C>
Asian Equity..................................................         0.80%           1.31%         1.56%
Japanese Equity...............................................         0.80%           1.14%         1.38%
</TABLE>
 
** Other expenses for the fiscal year ended December 31, 1997 would have been
   0.51% if certain expenses not expected to recur in 1998 had been included.
 
                                       2
<PAGE>
    The purpose of the table is to assist the investor in understanding the
various expenses that an investor in the Portfolios will bear directly or
indirectly. Expenses and fees are based on actual figures for the fiscal year
ended December 31, 1997. Due to the continuous nature of Rule 12b-1 fees,
long-term Class B shareholders may pay more than the equivalent of the maximum
front-end sales charges otherwise permitted by the National Association of
Securities Dealers, Inc. ("NASD") Conduct Rules.
 
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (i) a 5% annual rate of return, and (ii) redemption
at the end of each time period. As noted in the table above, the Portfolios
charge no redemption fees of any kind. The following example is based on total
operating expenses of the Portfolios after fee waivers.
 
<TABLE>
<CAPTION>
                                               3       5       10
                                     1 YEAR  YEARS   YEARS    YEARS
                                     ------  ------  ------  -------
<S>                                  <C>     <C>     <C>     <C>
Asian Equity Portfolio
  Class A..........................  $  10   $  32   $  55   $  122
  Class B..........................     13      40      69      151
Japanese Equity Portfolio
  Class A..........................     10      32      55      122
  Class B..........................     13      40      69      151
</TABLE>
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. ACTUAL EXPENSES MAY BE GREATER OR LESS THAN THOSE
SHOWN.
 
                                       3
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following tables provide financial highlights for the Class A and Class
B shares of the Portfolios for each of the periods presented. The audited
financial highlights for each of the Portfolio's shares for each of the periods
in the five years ended December 31, 1997 are part of the Fund's financial
statements which appear in the Fund's December 31, 1997 Annual Report to
Shareholders and which are incorporated by reference into the Fund's Statement
of Additional Information. Each Portfolio's financial highlights for each of the
periods presented have been audited by Price Waterhouse LLP, whose unqualified
report thereon is also incorporated by reference into the Statement of
Additional Information. Additional performance information is included in the
Annual Report. The Annual Report and the financial statements therein, along
with the Statement of Additional Information, are available at no cost from the
Fund at the address and telephone number noted on the cover page of this
Prospectus. After October 31, 1992, the Fund changed its fiscal year end to
December 31. The following information should be read in conjunction with
financial statements and notes thereto.
 
                                       4
<PAGE>
                             ASIAN EQUITY PORTFOLIO
<TABLE>
<CAPTION>
                                                                          CLASS A
                           -----------------------------------------------------------------------------------------------------
                                                                                                       TWO MONTHS
                                                   YEAR ENDED DECEMBER 31,                               ENDED       YEAR ENDED
                           ------------------------------------------------------------------------     DEC. 31,      OCT. 31,
                               1997           1996           1995           1994           1993           1992          1992
                           ------------   ------------   ------------   ------------   ------------   ------------   -----------
<S>                        <C>            <C>            <C>            <C>            <C>            <C>            <C>
NET ASSET VALUE,
 BEGINNING OF PERIOD.....    $    18.73     $    19.48     $    21.54     $    26.20     $    13.11     $    13.63     $    9.67
                           ------------   ------------   ------------   ------------   ------------   ------------   -----------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Income
   (1)...................          0.14           0.17           0.18           0.11           0.10           0.01          0.14
  Net Realized and
   Unrealized Gain (Loss)
   on Investments........         (8.93)          0.50           1.11          (4.15)         13.38          (0.53)         3.86
                           ------------   ------------   ------------   ------------   ------------   ------------   -----------
    Total from Investment
     Operations..........         (8.79)          0.67           1.29          (4.04)         13.48          (0.52)         4.00
                           ------------   ------------   ------------   ------------   ------------   ------------   -----------
DISTRIBUTIONS
  Net Investment
   Income................         (0.00)+        (0.15)         (0.34)         (0.09)         (0.01)            --         (0.04)
  In Excess of Net
   Investment Income.....            --          (0.00)+        (0.00+            --          (0.13)            --            --
  Net Realized Gain......            --          (1.27)         (3.01)         (0.53)         (0.12)            --            --
  In Excess of Net
   Realized Gain.........         (0.51)            --             --             --          (0.13)            --            --
                           ------------   ------------   ------------   ------------   ------------   ------------   -----------
    Total
     Distributions.......         (0.51)         (1.42)         (3.35)         (0.62)         (0.39)            --         (0.04)
                           ------------   ------------   ------------   ------------   ------------   ------------   -----------
NET ASSET VALUE, END OF
 PERIOD..................    $     9.43     $    18.73     $    19.48     $    21.54     $    26.20     $    13.11     $   13.63
                           ------------   ------------   ------------   ------------   ------------   ------------   -----------
                           ------------   ------------   ------------   ------------   ------------   ------------   -----------
TOTAL RETURN.............        (48.29)%         3.49%          6.87%        (15.81)%       105.71%         (3.82)%       41.50%
                           ------------   ------------   ------------   ------------   ------------   ------------   -----------
                           ------------   ------------   ------------   ------------   ------------   ------------   -----------
RATIOS AND SUPPLEMENTAL
 DATA:
  Net Assets, End of
   Period (Thousands)....    $   85,503     $  363,498     $  314,884     $  276,906     $  287,136     $   41,978     $  41,017
  Ratio of Expenses to
   Average Net Assets
   (1)...................          1.12%          1.00%          1.00%          1.00%          1.00%          1.00%**        1.00%
  Ratio of Expenses to
   Average Net Assets
   Excluding Country Tax
   Expense and Interest
   Expense...............          1.00%          1.00%          1.00%          1.00%          1.00%          1.00%**        1.00%
  Ratio of Net Investment
   Income to Average Net
   Assets (1)............          0.47%          0.74%          0.97%          0.52%          0.83%          0.61%**        1.53%
  Portfolio Turnover
   Rate..................           107%           %69             42%            47%            18%            10%           33%
  Average Commission Rate
   Per Share#............    $   0.0102     $   0.0111            N/A            N/A            N/A            N/A           N/A
 
<CAPTION>
                                                    CLASS B
                                          ---------------------------
                                                         PERIOD FROM
                                                           JAN. 2,
                            JULY 1* TO     YEAR ENDED     1996*** TO
                             OCT. 31,       DEC. 31,       DEC. 31,
                               1991           1997           1996
                           ------------   ------------   ------------
<S>                        <C>            <C>            <C>
NET ASSET VALUE,
 BEGINNING OF PERIOD.....    $    10.00     $    18.74     $  19.55
                           ------------   ------------   ------------
INCOME FROM INVESTMENT
 OPERATIONS
  Net Investment Income
   (1)...................          0.03           0.03         0.11
  Net Realized and
   Unrealized Gain (Loss)
   on Investments........         (0.36)         (8.86)        0.46
                           ------------   ------------   ------------
    Total from Investment
     Operations..........         (0.33)         (8.83)        0.57
                           ------------   ------------   ------------
DISTRIBUTIONS
  Net Investment
   Income................            --          (0.00)+      (0.11)
  In Excess of Net
   Investment Income.....            --             --           --
  Net Realized Gain......            --             --        (1.27)
  In Excess of Net
   Realized Gain.........            --          (0.51)          --
                           ------------   ------------   ------------
    Total
     Distributions.......            --          (0.51)       (1.38)
                           ------------   ------------   ------------
NET ASSET VALUE, END OF
 PERIOD..................    $     9.67     $     9.40     $  18.74
                           ------------   ------------   ------------
                           ------------   ------------   ------------
TOTAL RETURN.............         (3.30)%       (48.48)%      2.92%
                           ------------   ------------   ------------
                           ------------   ------------   ------------
RATIOS AND SUPPLEMENTAL
 DATA:
  Net Assets, End of
   Period (Thousands)....    $   10,719     $    1,468     $ 11,002
  Ratio of Expenses to
   Average Net Assets
   (1)...................          1.00%**         1.37%       1.25%**
  Ratio of Expenses to
   Average Net Assets
   Excluding Country Tax
   Expense and Interest
   Expense...............          1.00%**         1.25%       1.25%**
  Ratio of Net Investment
   Income to Average Net
   Assets (1)............          1.13%**         0.18%       0.58%**
  Portfolio Turnover
   Rate..................            %2            107%          69%
  Average Commission Rate
   Per Share#............           N/A     $   0.0102     $ 0.0111
</TABLE>
 
- ----------------------------------
<TABLE>
<C> <S>                     <C>         <C>         <C>             <C>            <C>            <C>            <C>
Average Commission Rate
as a
 Percentage of Trade
Amount#..................       0.46%       0.52%        N/A             N/A            N/A            N/A            N/A
(1) Effect of voluntary
     expense limitation
     during the period:
      Per share benefit
       to net
       investment
       income............      $0.05       $0.05       $0.03           $0.04          $0.05          $0.02          $0.06
    Ratios before expense
     limitation:
      Expenses to Average
       Net Assets........       1.31%       1.25%       1.18%           1.20%          1.38%          2.02%**        1.63%
      Net Investment
       Income to Average
       Net Assets........       0.29%       0.54%       0.79%           0.32%          0.45%        (0.41)%**        0.90%
 
<CAPTION>
Ave
 Pe
Amo       N/A        0.46%         0.52%
(1)
 
        $0.02       $0.04         $0.04
 
         2.52%**     1.56%         1.52%**
 
      (0.39)%**    (0.01)%         0.37%**
 
<CAPTION>
as
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
  + Amount is less than $0.01 per share.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
 
   commissions were charged, during the period.
 
                                       5
<PAGE>
                           JAPANESE EQUITY PORTFOLIO
<TABLE>
<CAPTION>
                                                                          CLASS A                                 CLASS B
                                               -------------------------------------------------------------   -------------
                                                                                                PERIOD FROM
                                                                                                 APRIL 25,
                                                          YEAR ENDED DECEMBER 31,                1994* TO       YEAR ENDED
                                               ---------------------------------------------   DECEMBER 31,    DECEMBER 31,
                                                   1997           1996++           1995            1994            1997
                                               -------------   -------------   -------------   -------------   -------------
<S>                                            <C>             <C>             <C>             <C>             <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........  $    7.96       $    9.27       $    9.83       $   10.00       $    7.94
                                               -------------   -------------   -------------   -------------   -------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (Loss) (1)...........       0.17              --            0.04           (0.01)           0.09
  Net Realized and Unrealized Loss on
   Investments+..............................      (0.94)          (0.13)          (0.40)          (0.16)          (0.89)
                                               -------------   -------------   -------------   -------------   -------------
    Total from Investment Operations.........      (0.77)          (0.13)          (0.36)          (0.17)          (0.80)
                                               -------------   -------------   -------------   -------------   -------------
DISTRIBUTIONS
  Net Investment Income......................      (1.30)          (0.66)             --              --           (1.27)
  In Excess of Net Investment Income.........         --           (0.52)          (0.20)             --              --
                                               -------------   -------------   -------------   -------------   -------------
    Total Distributions......................      (1.30)          (1.18)          (0.20)             --           (1.27)
                                               -------------   -------------   -------------   -------------   -------------
NET ASSET VALUE, END OF PERIOD...............  $    5.89       $    7.96       $    9.27       $    9.83       $    5.87
                                               -------------   -------------   -------------   -------------   -------------
                                               -------------   -------------   -------------   -------------   -------------
TOTAL RETURN.................................      (9.23)%         (1.40)%         (3.64)%         (1.70)%         (9.64)%
                                               -------------   -------------   -------------   -------------   -------------
                                               -------------   -------------   -------------   -------------   -------------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)......  $  77,086       $ 152,229       $ 119,278       $  50,332       $   1,703
  Ratio of Expenses to Average Net Assets
   (1).......................................       1.06%           1.00%           1.00%           1.00%**         1.31%
  Ratio of Expenses to Average Net Assets
   Excluding Interest Expense................       1.00%           1.00%           1.00%           1.00%**         1.25%
  Ratio of Net Investment Income (Loss) to
   Average Net Assets (1)....................      (0.21)%         (0.04)%          0.15%          (0.10)%**       (0.53)%
  Portfolio Turnover Rate....................         40%             38%             52%              1%             40%
  Average Commission Rate Per Share#.........    $0.0425         $0.0561             N/A             N/A         $0.0425
 
<CAPTION>
 
                                                PERIOD FROM
                                                JANUARY 2,
                                                1996*** TO
                                               DECEMBER 31,
                                                  1996++
                                               -------------
<S>                                            <C>
NET ASSET VALUE, BEGINNING OF PERIOD.........  $    9.25
                                               -------------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (Loss) (1)...........      (0.02)
  Net Realized and Unrealized Loss on
   Investments+..............................      (0.14)
                                               -------------
    Total from Investment Operations.........      (0.16)
                                               -------------
DISTRIBUTIONS
  Net Investment Income......................      (0.64)
  In Excess of Net Investment Income.........      (0.51)
                                               -------------
    Total Distributions......................      (1.15)
                                               -------------
NET ASSET VALUE, END OF PERIOD...............  $    7.94
                                               -------------
                                               -------------
TOTAL RETURN.................................      (1.67)%
                                               -------------
                                               -------------
RATIOS AND SUPPLEMENTAL DATA:
  Net Assets, End of Period (Thousands)......     $3,431
  Ratio of Expenses to Average Net Assets
   (1).......................................       1.25%**
  Ratio of Expenses to Average Net Assets
   Excluding Interest Expense................       1.25%**
  Ratio of Net Investment Income (Loss) to
   Average Net Assets (1)....................      (0.26)%**
  Portfolio Turnover Rate....................         38%
  Average Commission Rate Per Share#.........    $0.0561
</TABLE>
 
- ------------------------------
 
<TABLE>
<C> <S>                                         <C>         <C>             <C>             <C>         <C>             <C>
Average Commission Rate as
 a Percentage of Trade Amount#...............       0.41%       0.43%            N/A             N/A        0.41%           0.43%
(1) Effect of voluntary expense limitation
     during the period:
      Per share benefit to net investment
       income (loss).........................      $0.01       $0.01           $0.06           $0.02       $0.01           $0.01
    Ratios before expense limitation:
      Expenses to Average Net Assets.........       1.14%       1.07%           1.20%           1.27%**     1.38%           1.31%**
      Net Investment Income (Loss) to Average
       Net Assets............................      (0.28)%     (0.11)%         (0.05)%         (0.37)%**    (0.60)%        (0.32)%**
</TABLE>
 
- --------------------------------------------------------------------------------
  * Commencement of operations
 
 ** Annualized
 
*** The Portfolio began offering Class B shares on January 2, 1996.
 
  + The amount shown for the year ended December 31, 1995 for a share
    outstanding throughout the year does not agree with the amount of aggregate
    net gains on investments for the year because of the timing of sales and
    repurchases of the Portfolio shares in relation to fluctuating market value
    of the investments in the Portfolio.
 
 ++ Per share amounts for the year ended December 31, 1996 are based on average
    shares outstanding.
 
 # Beginning with fiscal year 1996, the Portfolio is required to disclose the
   average commission rate per share it paid for portfolio trades, on which
   commissions were charged, during the period.
 
                                       6
<PAGE>
                               PROSPECTUS SUMMARY
 
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and high net worth individual investors a broad range of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates providing customized services as Adviser, Administrator and
Distributor. Each portfolio offers Class A shares and Class B shares, except for
the International Small Cap and Municipal Money Market Portfolios which offer
only Class A shares. Each portfolio has its own investment objective and
policies designed to meet its specific goals. The investment objective of each
Portfolio described in this Prospectus is as follows:
 
    -The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Asian issuers.
 
    -The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Japanese issuers.
 
    The other portfolios of the Fund are described in other prospectuses which
may be obtained from the Fund at the address and phone number noted on the cover
page of this Prospectus. The investment objectives of these other portfolios are
listed below:
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    -The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
     appreciation by investing in accordance with country weightings determined
     by the Adviser in equity securities of non-U.S. issuers which, in the
     aggregate, replicate broad country indices.
 
    -The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
     appreciation by investing primarily in equity securities of companies in
     the Asian real estate industry.
 
    -The CHINA GROWTH PORTFOLIO seeks to provide long-term capital appreciation
     by investing primarily in equity securities of issuers in The People's
     Republic of China, Hong Kong and Taiwan.
 
    -The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of emerging country issuers.
 
    -The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of European issuers.
 
    -The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income and
     long-term capital appreciation by investing primarily in equity securities
     of companies in the European real estate industry.
 
    -The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers throughout the world,
     including U.S. issuers.
 
    -The GOLD PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of foreign and domestic issuers engaged in
     gold-related activities.
 
    -The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers.
 
    -The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers domiciled in
     EAFE countries.
 
                                       7
<PAGE>
    -The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
     by investing primarily in equity securities of non-U.S. issuers with equity
     market capitalizations of less than $1 billion.
 
    -The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Latin American issuers and,
     from time to time, debt securities issued or guaranteed by Latin American
     governments or governmental entities.
 
    U.S. EQUITY:
 
    -The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by investing
     primarily in corporate equity and equity-linked securities.
 
    -The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing primarily in growth-oriented equity securities of small- to
     medium-sized corporations.
 
    -The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing in growth-oriented equity securities of medium and large
     capitalization companies.
 
    -The MICROCAP PORTFOLIO seeks long-term capital appreciation by investing
     primarily in growth-oriented equity securities of small corporations.
 
    -The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total return by
     investing in equity securities of small- to medium-sized companies which
     the Adviser believes to be undervalued.
 
    -The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of companies that, in the opinion of the
     Adviser, are expected to benefit from their involvement in technology and
     technology-related industries.
 
    -The U.S. EQUITY PLUS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers included in the S&P 500
     Index ("S&P 500").
 
    -The U.S. REAL ESTATE PORTFOLIO seeks to provide above-average current
     income and long-term capital appreciation by investing primarily in equity
     securities of companies in the U.S. real estate industry, including
     substantial investment in real estate investment trusts.
 
    -The VALUE EQUITY PORTFOLIO seeks high total return by investing in equity
     securities which the Adviser believes to be undervalued relative to the
     stock market in general at the time of purchase.
 
    EQUITY AND FIXED INCOME:
 
    -The BALANCED PORTFOLIO seeks high total return while preserving capital by
     investing in a combination of equity securities which the Adviser believes
     to be undervalued and fixed income securities.
 
    FIXED INCOME:
 
    -The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by investing
     primarily in debt securities of government, government-related and
     corporate issuers located in emerging countries.
 
    -The FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
     with the preservation of capital by investing in a diversified portfolio of
     fixed income securities.
 
    -The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
     of return while preserving capital by investing in fixed income securities
     of issuers throughout the world, including U.S. issuers.
 
                                       8
<PAGE>
    -The HIGH YIELD PORTFOLIO seeks to maximize total return by investing in a
     diversified portfolio of high yield fixed income securities that offer a
     yield above that generally available on debt securities in the four highest
     rating categories of the recognized rating services.
 
    -The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a level
     of current income as is consistent with the preservation of capital by
     investing primarily in a variety of investment grade mortgage-backed
     securities.
 
    -The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of current
     income consistent with preservation of principal by investing in municipal
     obligations, the interest on which is exempt from federal income tax.
 
    MONEY MARKET:
 
    -The MONEY MARKET PORTFOLIO seeks to maximize current income and preserve
     capital while maintaining high levels of liquidity through investing in
     high-quality money market instruments with remaining maturities of one year
     or less.
 
    -
    The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current tax-exempt
    income and preserve capital while maintaining high levels of liquidity
    through investing in high-quality money market instruments with remaining
    maturities of one year or less which are exempt from federal income tax.
 
    THE CHINA GROWTH, GOLD, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS
    ARE CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley Dean Witter & Co., acts as investment adviser to the Fund and each of
its portfolios. As of March 31, 1998, Morgan Stanley Asset Management Inc. and
its affiliated institutional asset management companies managed assets of
approximately $166 billion, including assets under fiduciary advice. See
"Management of the Fund -- Investment Adviser" and "Management of the Fund --
Administrator."
 
HOW TO INVEST
 
    Class A shares of each Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of each
Portfolio are offered at net asset value with no sales commission, but with a
12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25% of the
Class B shares' average daily net assets on an annualized basis. The minimum
initial investment, generally, is $500,000 for Class A shares of each Portfolio
and $100,000 for Class B shares of each Portfolio. The minimum initial
investment amount is reduced for certain categories of investors. For additional
information on how to purchase shares and minimum initial investments, see
"Purchase of Shares."
 
HOW TO REDEEM
 
    Class A shares or Class B shares of each Portfolio may be redeemed at any
time, without cost, at the net asset value per share of the applicable class
next determined after receipt of the redemption request. The redemption price
may be more or less than the purchase price. Certain redemptions that cause the
value of an account to remain for a continuous 60-day period below the minimum
investment amount for Class A shares or for Class B shares may result in
involuntary redemption or automatic conversion. For additional information on
how to redeem shares and involuntary redemption or conversion, see "Purchase of
Shares" and "Redemption of Shares."
 
                                       9
<PAGE>
RISK FACTORS
 
    Investing in each of the Portfolios entails certain risks and considerations
of which an investor should be aware. The Portfolios' share prices and
investment returns fluctuate and, when redeemed, an investment in the Portfolios
may be worth more or less than its original cost. The investment policies of the
Portfolios may entail the following risk factors:
 
    -
    EQUITY SECURITIES. Each Portfolio invests in equity securities. Prices of
    equity securities fluctuate in response to many factors, including the
    financial health of the issuer and changes in economic and market
    conditions.
 
    -
    FIXED INCOME SECURITIES. The Japanese Equity Portfolio will be subject to
    credit risk and market risk associated with investment in fixed income
    securities. Credit risk is the possibility that an issuer may be unable to
    meet scheduled principal and interest payments. Market risk is the
    possibility that a change in interest rates or the market's perception of
    the issuer's prospects may adversely affect the value of a fixed income
    security.
 
    -
    FOREIGN INVESTMENT. Each Portfolio will invest in the securities of foreign
    issuers. The risks of foreign investment include fluctuations in foreign
    currency values, political events affecting the country of issuance and
    potentially greater market volatility and lower liquidity.
 
    -
    EMERGING MARKET COUNTRY SECURITIES. The Asian Equity Portfolio may invest in
    emerging market country securities which entail risks typically associated
    with investment in more established foreign markets. However, these risks
    may be intensified due to higher volatility and less liquidity of emerging
    markets, possible political risks associated with the country of issuance
    and generally weaker financial condition of issuers in these markets.
 
    -
    DERIVATIVES. Each Portfolio may invest in instruments that derive their
    values from those of specified securities, indices, currencies or other
    points of reference. These derivatives, including those used to manage risk,
    are themselves subject to the risks of the different markets in which they
    are traded and, therefore, may or may not serve their intended purposes.
 
    For additional information about risk factors, see also "Investment
Objectives and Policies" and "Additional Investment Information."
 
                                       10
<PAGE>
                       INVESTMENT OBJECTIVES AND POLICIES
 
    The investment objective of each Portfolio is described below, together with
the policies each Portfolio will employ in its efforts to achieve its objective.
Each Portfolio's investment objective is a fundamental policy which may not be
changed without the approval of a majority of the Portfolio's outstanding voting
securities. There is no assurance that the Portfolios will attain their
objectives. Each of the Portfolios invests in equity securities, which include
common and preferred stocks, convertible securities, rights and warrants to
purchase common stocks. In addition to the investments and strategies described
below, the Portfolios may invest in certain securities and obligations as set
forth in "Additional Investment Information" and as described under "Investment
Objectives and Policies" in the Statement of Additional Information. The
investment policies described below are not fundamental policies unless
otherwise noted and may be changed without shareholder approval.
 
THE ASIAN EQUITY PORTFOLIO
 
    The investment objective of the Asian Equity Portfolio is to provide
long-term capital appreciation. The production of any current income is
incidental to this objective. The Portfolio seeks to achieve its objective by
investing primarily in equity securities which are traded on recognized stock
exchanges of the countries in Asia described below and in equity securities of
companies organized under the laws of an Asian country whose business is
conducted principally in Asia. The Portfolio does not intend to invest in equity
securities which are principally traded in markets in Japan or in companies
organized under the laws of Japan.
 
    The Portfolio will invest primarily in the more established Asian markets,
including Hong Kong, Singapore, Malaysia, Thailand, the Philippines and
Indonesia. The Portfolio may also invest in common stocks traded on markets in
Taiwan, South Korea, India, Pakistan, Sri Lanka and other emerging markets that
are open to foreign investment. There is no requirement that the Portfolio, at
any given time, invest in any or all of the countries listed above or in any
other Asian countries. The Portfolio has no set policy for allocating
investments among the various Asian countries. Allocation of investments will
depend on the relative attractiveness of the stocks of issuers in the respective
countries. Government regulation and restrictions in many of the countries of
interest may limit the amount, mode and extent of investment in companies of
such countries.
 
    Under normal circumstances, at least 65% of the total assets of the
Portfolio will be invested in common stocks of Asian countries. The Portfolio
may also invest in Depositary Receipts of Asian issuers and equity securities
traded in over-the-counter markets. The remaining portion of the Portfolio will
be kept in any combination of debt instruments, bills and bonds of governmental
entities in Asia and the United States, in notes, debentures and bonds of
companies in Asia and in money market instruments. Pending investment or
settlement, and for liquidity purposes, the Portfolio may invest in domestic,
Eurodollar and foreign short-term money market instruments. The Portfolio may
also invest in initial public offerings in the form of oversubscriptions or
private placements. Such investments generally entail short-term liquidity
risks.
 
    The Adviser's approach in selecting investments for the Portfolio is
oriented to individual stock selection, and is value driven. In selecting stocks
for the Portfolio, the Adviser initially identifies those stocks which it
believes to be undervalued in relation to the issuer's assets, cash flow,
earnings and revenues, and then evaluates the future value of such stocks by
running the results of an in-depth study of the issuer through a dividend
discount model. The Adviser utilizes the research of a number of sources,
including Morgan Stanley Capital International, an affiliate of the Adviser
located in Geneva, Switzerland, in identifying attractive securities, and
applies a number of proprietary screening criteria to identify those securities
it believes to be undervalued.
 
                                       11
<PAGE>
Portfolio holdings are regularly reviewed and subjected to fundamental analysis
to determine whether they continue to conform to the Adviser's value criteria.
Securities which no longer conform to such value criteria are sold. The Adviser
will analyze assets, revenues and earnings of an issuer. In selecting industries
and particular issuers, the Adviser will evaluate costs of labor and raw
materials, access to technology, export of products and government regulation.
Although the Portfolio seeks to invest in larger companies, it may invest in
medium-sized and small companies that, in the Adviser's opinion, have potential
for growth.
 
THE JAPANESE EQUITY PORTFOLIO
 
    The investment objective of the Japanese Equity Portfolio is to provide
long-term capital appreciation. The Portfolio seeks to achieve this objective by
investing primarily in equity securities of Japanese issuers. Under normal
circumstances, the Portfolio will invest at least 80% of its total assets in
securities of issuers that are organized under the laws of Japan, affiliates of
Japanese companies (wherever organized or traded) and issuers not organized
under the laws of Japan but deriving 50% or more of their revenues from Japan.
The Portfolio currently intends to focus its investments in Japanese companies
that have an active market for their shares and that the Adviser believes show a
potential for above-average growth. In making investment decisions, the Adviser
will consider, among other factors, the size of the company, its financial
condition, its marketing and technical strengths and its competitiveness in its
industry. The Portfolio anticipates that most equity securities of Japanese
companies in which it invests, either directly or indirectly by means of
Depositary Receipts or convertible debentures, will be listed on securities
exchanges in Japan. The Portfolio may also invest in equity securities of
Japanese companies that are traded in an over-the-counter market.
 
    The Portfolio also may invest in debt securities (issued by the Japanese
government or by Japanese companies) when the Adviser believes that the
potential for capital appreciation from investment in debt securities equals or
exceeds that available from investment in equity securities. All debt securities
in which the Portfolio may invest will be rated investment grade or, if unrated,
of comparable quality as determined by the Adviser. The convertible securities
in which the Portfolio may invest include bonds, notes, debentures, preferred
stocks and other securities convertible into common stocks and may be fixed
income or zero coupon debt securities. Prior to their conversion, convertible
securities may have characteristics similar to non-convertible debt securities.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    DEPOSITARY RECEIPTS.  The Portfolios may invest in Depositary Receipts,
including American Depositary Receipts ("ADRs"), Global Depositary Receipts
("GDRs"), European Depositary Receipts ("EDRs") and other Depositary Receipts
(which, together with ADRs, GDRs and EDRs, are hereinafter collectively referred
to as "Depositary Receipts"), to the extent that such Depositary Receipts are or
become available. ADRs are securities, typically issued by a U.S. financial
institution (a "depositary"), that evidence ownership interests in a security or
a pool of securities issued by a foreign issuer (the "underlying issuer") and
deposited with the depositary. ADRs may be "sponsored" or "unsponsored."
Sponsored ADRs are established jointly by a depositary and the underlying
issuer, whereas unsponsored ADRs may be established by a depositary without
participation by the underlying issuer. The issuers of the stock of unsponsored
ADRs are not obligated to disclose material information in the United States and
therefore, there may not be a correlation between such information and the
market value of the ADR. GDRs, EDRs and other types of Depositary Receipts are
typically issued by foreign depositaries, although they may also be issued by
U.S. depositaries, and evidence ownership
 
                                       12
<PAGE>
interests in a security or pool of securities issued by either a foreign or a
U.S. corporation. Generally, Depositary Receipts in registered form are designed
for use in the U.S. securities market and Depositary Receipts in bearer form are
designed for use in securities markets outside the United States. The Portfolios
may invest in sponsored and unsponsored Depositary Receipts. For purposes of the
Portfolios' investment policies, the Portfolios' investments in Depositary
Receipts will be deemed to be investments in the underlying securities.
 
    FIXED INCOME SECURITIES.  Each Portfolio will invest in fixed income (debt)
securities. The market value of the fixed income securities in which a Portfolio
invests will be affected by changes in the creditworthiness of issuers and will
change in response to interest rate changes and other factors. Generally, the
values of fixed income securities vary inversely with changes in interest rates,
so that during periods of falling interest rates, the values of outstanding
fixed income securities generally rise and during periods of rising interest
rates, the values of such securities generally decline. While securities with
longer maturities tend to produce higher yields, the prices of longer maturity
securities are subject to greater market fluctuations as a result of changes in
interest rates.
 
    FOREIGN CURRENCY FORWARD CONTRACTS.  Each Portfolio may enter into foreign
currency forward contracts ("forward contracts") that provide for the purchase
or sale of an amount of a specified currency at a future date. The Portfolios
may use such contracts to protect against a decline in a foreign currency
against the U.S. dollar between the trade date and settlement date when the
Portfolio purchases or sells securities, lock in the U.S. dollar value of
dividends and interest on securities held by the Portfolio, and generally to
protect the U.S. dollar value of securities held by the Portfolio against
exchange rate fluctuation. While forward contracts may limit losses as a result
of exchange rate fluctuations, they will also limit any gains that might
otherwise have been realized. The Portfolio's Custodian may be required to place
cash or liquid securities in a segregated account in an amount equal to the
value of the Portfolio's total assets committed to the consummation of forward
contracts. If the value of the securities placed in the segregated account
declines, additional cash or securities will be placed in the account on a daily
basis so that the value of the account will be at least equal to the amount of
the Portfolio's commitments with respect to such contracts.
 
    FOREIGN INVESTMENT.  Each Portfolio may invest in the securities of foreign
issuers. Investment in securities of foreign issuers involves investment risks
somewhat different from those affecting securities of U.S. issuers. The
Portfolio's investments will be subject to political and economic events that
affect the countries in which it invests. Foreign issuers may be subject to
different accounting, auditing and financial standards and requirements. There
also may be less government supervision and regulation of foreign securities
exchanges, brokers and listed companies than in the United States. Many foreign
securities markets have substantially less trading volume than U.S. national
securities exchanges and, therefore, securities of some foreign issuers are less
liquid and more volatile than securities of comparable U.S. issuers. Brokerage
commissions and other transaction costs on foreign securities exchanges are
generally higher than in the United States. Dividends and interest paid by
foreign issuers may be subject to withholding and other foreign taxes, which may
decrease the net return on foreign investments as compared to dividends and
interest paid to the Portfolios by domestic companies. Investments in securities
of foreign issuers are generally denominated in foreign currencies and, since a
Portfolio may temporarily hold uninvested reserves in bank deposits in foreign
currencies, the value of a Portfolio's assets as measured in U.S. dollars may be
affected favorably or unfavorably by changes in currency exchange rates and
exchange control regulations, and a Portfolio may incur costs in connection with
conversions between various currencies.
 
                                       13
<PAGE>
    The Asian Equity Portfolio may also invest in emerging market country
securities. Investing in emerging markets entails the risks associated with
foreign investment described above, however, these risks may be intensified in
emerging markets. Emerging markets can include every nation in the world except
the United States, Canada, Japan, Australia, New Zealand and most nations
located in Western Europe. Certain emerging market countries have historically
experienced, and may continue to experience, high rates of inflation, high
interest rates, exchange rate fluctuations, large amounts of external debt,
trade difficulties and unemployment. Further, the economies of developing
countries generally are heavily dependent upon international trade and,
accordingly, have been, and may continue to be, adversely affected by trade
barriers, exchange controls and other protectionist measures imposed or
negotiated by the countries in which they trade. There also are risks associated
with the possibility of nationalization, expropriation or confiscatory taxation,
political changes, government regulation, social instability or diplomatic
developments (including war) that could adversely affect the economies of such
countries or the value of the Portfolio's investments in those countries.
 
    The Asian Equity Portfolio may invest in securities of issuers located in
Hong Kong. Hong Kong was established as a British colony in the 1840's and,
until recently, was ruled by the British Government through an appointed
Governor. Effective July 1, 1997, Hong Kong reverted to Chinese sovereignty and
is governed as a Special Administrative Region of China. Although China has made
certain commitments to preserve the economic and social freedoms enjoyed in Hong
Kong during British rule, there can be no assurances China's commitments will be
maintained. Action taken by the Chinese government which limits or causes
uncertainty with regard to these economic and social freedoms could have an
adverse affect on the Portfolio's investments in securities of issuers located
in Hong Kong.
 
    LOANS OF PORTFOLIO SECURITIES.  Each Portfolio may lend its securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing net investment income. These loans must be secured
continuously by cash or equivalent collateral or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be risks of delay in recovery of the securities or even loss
of rights in the collateral should the borrower of the securities fail
financially. A Portfolio will not enter into securities loan transactions
exceeding in the aggregate 33 1/3% of the market value of the Portfolio's total
assets.
 
    MONEY MARKET INSTRUMENTS.  The Portfolios are permitted to invest in money
market instruments, although each Portfolio intends to stay invested in
securities satisfying its primary investment objective to the extent practical.
Consistent with their investment policies, each Portfolio may make money market
investments pending other investment or settlement for liquidity. In addition,
the Portfolios may invest in money market instruments for temporary defensive
purposes during adverse market conditions. The money market investments
permitted for the Portfolios include: obligations of the U.S. Government and its
agencies and instrumentalities, obligations of foreign sovereignties, commercial
paper, bank obligations (including certificates of deposit), other debt
securities and repurchase agreements.
 
    NON-PUBLICLY TRADED SECURITIES, PRIVATE PLACEMENTS AND RESTRICTED
SECURITIES.  The Asian Equity Portfolio may invest in securities that are
neither listed on a stock exchange nor traded over-the-counter, including
privately placed securities. Such unlisted equity securities may involve a
higher degree of business and financial risk that can result in substantial
losses. As a result of the absence of a public trading market for these
securities, they may be less liquid than publicly traded securities. Although
these securities may be resold in privately negotiated transactions, the prices
realized from these sales could be less than those originally paid
 
                                       14
<PAGE>
by the Portfolio or less than what may be considered the fair value of such
securities. Further, companies whose securities are not publicly traded may not
be subject to the disclosure and other investor protection requirements which
might be applicable if their securities were publicly traded. If such securities
are required to be registered under the securities laws of one or more
jurisdictions before being resold, the Portfolio may be required to bear the
expenses of registration.
 
    As a general matter, the Portfolio may not invest more than 15% of its net
assets in illiquid securities, including securities for which there is no
readily available secondary market. Also, as a general matter, the Portfolio may
not invest more than 10% of its total assets in securities that are restricted
from sale to the public without registration ("Restricted Securities") under the
Securities Act of 1933, as amended (the "1933 Act"). However, the Portfolio may
invest up to 25% of its total assets in liquid Restricted Securities that can be
offered and sold to qualified institutional buyers under Rule 144A under the
1933 Act ("Rule 144A Securities"). The Board of Directors has adopted guidelines
and delegated to the Adviser, subject to the supervision of the Board of
Directors, the daily function of determining and monitoring the liquidity of
Rule 144A Securities. Rule 144A Securities may become illiquid if qualified
institutional buyers are not interested in acquiring the securities.
 
    REPURCHASE AGREEMENTS.  Each Portfolio may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines established by
the Fund's Board of Directors. In a repurchase agreement, the Portfolio buys a
security from a seller that has agreed to repurchase it at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of the
agreement. The term of these agreements is usually from overnight to one week
and never exceeds one year. A repurchase agreement may be viewed as a fully
collateralized loan of money by the Portfolio to the seller. The Portfolio
always receives securities with a market value at least equal to the purchase
price (including accrued interest) as collateral, and this value is maintained
during the term of the agreement. If the seller defaults and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with respect to the seller, the Portfolio's realization upon the
collateral may be delayed or limited. The Portfolio may not enter into
repurchase agreements with more than seven days to maturity if, as a result,
more than 15% of the market value of the Portfolio's net assets are invested in
these agreements and other investments for which market quotations are not
readily available or which are otherwise illiquid.
 
    TEMPORARY INVESTMENTS.  During periods in which the Adviser believes changes
in economic, financial or political conditions make it advisable, each Portfolio
may, for temporary defensive purposes, invest up to 100% of its total assets in
certain short-term and medium-term debt obligations or hold cash. The short-term
and medium-term debt obligations in which a Portfolio may invest consist of (i)
obligations of the U.S. or foreign governments, their respective agencies or
instrumentalities; (ii) money market instruments; and (iii) instruments
denominated in any currency issued by international development agencies.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  Each Portfolio may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Delivery of and payment for these securities may take
as long as a month or more after the date of the purchase commitment but will
take place no more than 120 days after the trade date. Each Portfolio will
maintain with the Custodian a segregated account of cash or liquid securities in
an amount at least equal to these commitments. The payment obligation and the
interest rates that will be received are each fixed at the time a Portfolio
enters into the commitment and no interest accrues to the Portfolio until
settlement. Thus, it is possible
 
                                       15
<PAGE>
that the market value at the time of settlement could be higher or lower than
the purchase price if, among other factors, the general level of interest rates
has changed. It is a current policy of each Portfolio not to enter into
when-issued commitments or delayed delivery securities exceeding in the
aggregate 15% of the market value of the Portfolio's total assets less
liabilities, other than the obligations created by these commitments.
 
DERIVATIVE PRODUCTS (DERIVATIVES)
 
    The Portfolios are permitted to utilize various exchange-traded and
over-the-counter derivative instruments and derivative securities, both for
hedging and non-hedging purposes. Permitted derivative products include, but are
not limited to: futures contracts ("futures"); forward contracts ("forwards");
options; swaps, caps, collars and floors; structured notes; and other derivative
products yet to be developed, so long as these new products are used in a manner
consistent with the objectives of the Portfolios. These derivative products may
be based upon a wide variety of underlying rates, indices, instruments,
securities and other products, such as interest rates, foreign currencies,
foreign and domestic fixed income and equity securities, groups or "baskets" of
securities and securities indices (for each derivative product, the
"underlying"). Exclusive of forward foreign currency contracts and any
derivative products used for hedging purposes, each Portfolio will limit its use
of derivative products to 33 1/3% of its total assets, measured by the aggregate
notional amount of outstanding derivative products.
 
    The Portfolios may use derivative products under a number of different
circumstances to further their investment objectives. For example, a Portfolio
may purchase derivatives to gain exposure to a market quickly in response to
changes in the Portfolio's investment strategy, upon the inflow of investable
cash or when the derivative provides greater liquidity than the underlying
market. A Portfolio may also use derivatives when it is restricted from directly
owning the "underlying" or when derivatives provide a pricing advantage or lower
transaction costs. The Portfolios also may purchase combinations of derivatives
in order to gain exposure to an investment in lieu of actually purchasing such
investment. Derivatives may also be used by a Portfolio for hedging or risk
management purposes and in other circumstances when the Adviser believes it
advantageous to do so consistent with the Portfolio's investment objectives and
policies. The Portfolios will not use derivatives in a manner that creates
leverage, except to the extent that the use of leverage is expressly permitted
by a particular Portfolio's investment policies, and then only in a manner
consistent with such policies.
 
    The use of derivative products is a highly specialized activity which
involves investment techniques and risks different from those associated with
ordinary portfolio securities transactions. If the Adviser is incorrect in
forecasts of market values, interest rates, and currency exchange rates, the
investment performance of the Portfolios will be less favorable than it would
have been if these investment techniques had not been used.
 
    Some of the derivative products in which the Portfolios may invest and some
of the risks related thereto are described in more detail below.
 
FUTURES CONTRACTS (FUTURES) AND FORWARD CONTRACTS (FORWARDS)
 
    The Portfolios may purchase and sell futures contracts, such as futures on
securities indices, baskets of securities, foreign currencies and interest rates
of the type generally known as financial futures. These are standardized
contracts that are bought and sold on organized exchanges. A futures contract
obligates a party to buy or sell a specific amount of the "underlying," such as
for example, a particular foreign currency, on a specified future date at a
specified price or to settle the value in cash.
 
                                       16
<PAGE>
    The Portfolios may also purchase and sell forward contracts, such as forward
rate agreements and other financial forward contracts. The Portfolios may also
use foreign currency forward contracts which are separately discussed elsewhere
in this Prospectus. See "Foreign Currency Forward Contracts" above. These
forward contracts are privately negotiated and are bought and sold in the
over-the-counter market. Like a future, a forward contract obligates a party to
buy or sell a specific amount of the underlying on a specified future date at a
specified price. The terms of the forward contract are customized. Forward
contracts, like other over-the-counter contracts that are negotiated directly
with an individual counterparty, subject the Portfolio to the risk of
counterparty default.
 
    In some cases, the Portfolios may be able to use either futures contracts,
forward contracts or exchange-traded or over-the-counter options to accomplish
similar purposes. In all cases, the Portfolios will use these products only as
permitted by applicable laws and regulations. Some of the ways in which the
Portfolios may utilize futures contracts, forward contracts and related options
are as follows:
 
    The Portfolios may sell securities index futures contracts and/or index
options thereon in anticipation of or during a market decline to attempt to
offset the decrease in market value of investments in its portfolio, or may
purchase securities index futures or options in order to gain market exposure.
There currently are limited securities index futures and options on such futures
in many countries, particularly emerging countries. The nature of the strategies
adopted by the Adviser, and the extent to which those strategies are used, may
depend on the development of such markets. The Portfolios may also purchase and
sell foreign currency futures to hedge their respective holdings and commitments
against changes in the level of future currency rates or to adjust their
exposure to a particular currency.
 
    The Portfolios may engage in transactions in interest rate futures and
related products. The value of these contracts rises and falls inversely with
changes in interest rates. The Portfolios may engage in such transactions to
hedge their holdings of debt instruments against future changes in interest
rates or for other purposes.
 
    The Portfolios may also purchase or sell futures and forwards on other
financial instruments, such as U.S. Government securities and certificates of
deposit. The value of these contracts also rises and falls inversely with
changes in interest rates. The Portfolios may engage in financial futures and
forward contracts for both hedging and non-hedging purposes.
 
    Gains and losses on futures contracts, forward contracts and related options
depend on the Adviser's ability to predict correctly the direction of securities
prices, interest rates and other economic factors. Other risks associated with
the use of these instruments include (i) imperfect correlation between the
change in market value of investments held by a Portfolio and the prices of
derivative products relating to investments purchased or sold by the Portfolio,
and (ii) possible lack of a liquid secondary market for a derivative product and
the resulting inability to close out a position. The risk that a Portfolio will
be unable to close out a position will be minimized by only entering into
transactions for which there appears to be a liquid exchange or secondary
market. In some strategies, the risk of loss in trading on futures and related
transactions can be substantial, due both to the low margin deposits required
and the extremely high degree of leverage involved in pricing.
 
    Under rules adopted by the Commodity Futures Trading Commission (the
"CFTC"), each Portfolio may, without registering with the CFTC as a Commodity
Pool Operator, enter into futures contracts and options
 
                                       17
<PAGE>
thereon for both hedging and non-hedging purposes, provided that not more than
5% of such Portfolio's total assets at the time of entering the transaction are
required as margin and option premiums to secure obligations under such
contracts relating to non-bona fide hedging activities.
 
OPTION TRANSACTIONS
 
    The Portfolios may seek to increase their returns or may hedge their
portfolio investments through options transactions with respect to individual
securities, indices or baskets in which such Portfolios may invest; other
financial instruments; and foreign currency. Various options may be purchased
and sold on either the exchange-traded or over-the-counter markets.
 
    Each Portfolio may purchase put and call options. Purchasing a put option
gives a Portfolio the right, but not the obligation, to sell the underlying
(such as a securities index or a particular foreign currency) at the exercise
price either on a specific date or during a specified exercise period.
Purchasing a call option gives a Portfolio a similar right, but not the
obligation, to purchase the underlying. The purchaser pays a premium to the
seller (also known as the writer) of the option.
 
    Each Portfolio also may write put and call options on investments held in
its portfolio, as well as foreign currency options. A Portfolio that has written
an option receives a premium that increases the Portfolio's return on the
underlying in the event the option expires unexercised or is closed out at a
profit. However, by writing a call option, a Portfolio will limit its
opportunity to profit from an increase in the market value of the underlying
above the exercise price of the option. By writing a put option, a Portfolio
will be exposed to the amount by which the price of the underlying is less than
the strike price.
 
    By writing an option, a Portfolio incurs an obligation either to buy (in the
case of a put option) or sell (in the case of a call option) the underlying from
the purchaser of the option at the option's exercise price, upon exercise by the
purchaser. Pursuant to guidelines established by the Board of Directors, the
Portfolios may only write options that are "covered." A covered call option
means that until the expiration of the option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will continue to own (i) the underlying; (ii) securities or instruments
convertible or exchangeable without the payment of any consideration into the
underlying; or (iii) a call option on the same underlying with a strike price no
higher than the price at which the underlying was sold pursuant to a short
option position. In the case of a put option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will own another put option on the same underlying with an equal or higher
strike price.
 
    There currently are limited options markets in many countries, particularly
emerging market countries, and the nature of the strategies adopted by the
Adviser and the extent to which those strategies are used will depend on the
development of these options markets. The primary risks associated with the
Portfolios' use of options as described include (i) imperfect correlation
between the change in market value of investments held, purchased or sold by a
Portfolio and the prices of options relating to such investments, and (ii)
possible lack of a liquid secondary market for an option.
 
INTEREST RATE, CURRENCY, COMMODITY AND EQUITY SWAPS, CAPS, COLLARS AND FLOORS
 
    Swaps are privately negotiated over-the-counter derivative products in which
two parties agree to exchange payment streams calculated in relation to a rate,
index, instrument or certain securities and a particular "notional amount." As
with many of the other derivative products available to the Portfolios, the
underlying may
 
                                       18
<PAGE>
include an interest rate (fixed or floating), a currency exchange rate, a
commodity price index, and a security, securities index or a combination
thereof. A great deal of flexibility is possible in the way the products may be
structured, with the effect being that the parties may have exchanged amounts
equal to the return on one rate, index or group of securities for another. For
example, in a simple fixed-to-floating interest rate swap, one party makes
payments equivalent to a fixed interest rate, and the other makes payments
equivalent to a specified interest rate index. A Portfolio may engage in simple
or more complex swap transactions involving a wide variety of underlyings. The
currency swaps that the Portfolios may enter will generally involve an agreement
to pay interest streams in one currency based on a specified index in exchange
for receiving interest streams denominated in another currency. Such swaps may
involve initial and final exchanges that correspond to the agreed upon notional
amount.
 
    Caps, collars and floors are privately-negotiated option-based derivative
products. A Portfolio may use one or more of these products in addition to or in
lieu of a swap involving a similar rate or index. As in the case of a put or
call option, the buyer of a cap or floor pays a premium to the writer. In
exchange for that premium, the buyer receives the right to a payment equal to
the differential if the specified index or rate rises above (in the case of a
cap) or falls below (in the case of a floor) a pre-determined strike level. As
in the case of swaps, obligations under caps and floors are calculated based
upon an agreed notional amount, and like most swaps (other than foreign currency
swaps), the entire notional amount is not exchanged and thus is not at risk. A
collar is a combination product in which the same party, such as the Portfolio,
buys a cap from and sells a floor to the other party. As with put and call
options, the amount at risk is limited for the buyer, but, if the cap or floor
is not hedged or covered, may be unlimited for the seller. Under current market
practice, caps, collars and floors between the same two parties are generally
documented under the same "master agreement." In some cases, options and forward
agreements may also be governed by the same master agreement. In the event of a
default, amounts owed under all transactions entered into under, or covered by,
the same master agreement would be netted and only a single payment would be
made.
 
    Swaps, caps, collars and floors are credit-intensive products. A Portfolio
that enters into a swap transaction bears the risk of default, i.e. nonpayment,
by the other party. The guidelines under which each Portfolio enters derivative
transactions, along with some features of the transactions themselves, are
intended to reduce these risks to the extent reasonably practicable, although
they cannot eliminate the risks entirely. Under guidelines established by the
Board of Directors, a Portfolio may enter into swaps only with parties that meet
certain credit rating guidelines. Consistent with current market practices, a
Portfolio will generally enter into swap transactions on a net basis, and all
swap transactions with the same party will be documented under a single master
agreement to provide for net payment upon default. In addition, a Portfolio's
obligations under an agreement will be accrued daily (offset against any amounts
owing to the Portfolio) and any accrued, but unpaid, net amounts owed to the
other party to a master agreement will be covered by the maintenance of a
segregated account consisting of cash or liquid securities.
 
    Interest rate and total rate of return (fixed income or equity) swaps
generally do not involve the delivery of securities, other underlying assets, or
principal. In such case, if the other party to an interest rate or total rate of
return swap defaults, a Portfolio's risk of loss will consist of the payments
that a Portfolio is contractually entitled to receive from the other party. This
may not be true for currency swaps that require the delivery of the entire
notional amount of one designated currency in exchange for the other. If there
is a default by the other party, a Portfolio may have contractual remedies
pursuant to the agreements related to the transaction.
 
                                       19
<PAGE>
STRUCTURED NOTES
 
    Structured notes are derivative securities for which the amount of principal
repayment and/or interest payments is based upon the movement of one or more
factors. These factors include, but are not limited to, currency exchange rates,
interest rates (such as the prime lending rate and LIBOR) and stock indices,
such as the S&P 500. In some cases, the impact of the movements of these factors
may increase or decrease through the use of multipliers or deflators. The
Portfolios may use structured notes to tailor their investments to the specific
risks and returns the Adviser wishes to accept while avoiding or reducing
certain other risks.
 
                             INVESTMENT LIMITATIONS
 
    Each Portfolio is a diversified investment company under the Investment
Company Act of 1940, as amended (the "1940 Act") and is therefore subject to the
following limitations: (i) as to 75% of its total assets, a Portfolio may not
invest more than 5% of its total assets in the securities of any one issuer,
except obligations of the U.S. Government and its agencies and
instrumentalities, and (ii) a Portfolio may not own more than 10% of the
outstanding voting securities of any one issuer.
 
    Each Portfolio also operates under certain investment restrictions that are
deemed fundamental limitations and may be changed only with the approval of the
holders of a majority of such Portfolio's outstanding shares and under certain
non-fundamental investment limitations that may be changed without shareholder
approval. For additional information on fundamental and non-fundamental
investment limitations, see "Investment Limitations" in the Statement of
Additional Information.
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and each Portfolio. The Adviser provides investment
advice and portfolio management services pursuant to an Investment Advisory
Agreement and, subject to the supervision of the Fund's Board of Directors,
makes each of the Portfolio's day-to-day investment decisions, arranges for the
execution of portfolio transactions and generally manages each of the
Portfolio's investments. Set forth below as an annual percentage of average
daily net assets are the management fees payable to the Adviser quarterly by
each Portfolio pursuant to the terms of the Investment Advisory Agreement. The
Adviser has voluntarily agreed to a reduction in the fees payable to it and to
reimburse the Portfolios, if necessary, if such fees would cause total annual
operating expenses of the Portfolios to exceed the maximums set forth in the
table below.
 
<TABLE>
<CAPTION>
                                                                    MAXIMUM TOTAL ANNUAL
                                                                         OPERATING
                                              MANAGEMENT FEES    EXPENSES AFTER FEE WAIVERS
                                                ABSENT FEE       --------------------------
PORTFOLIO                                         WAIVERS          CLASS A       CLASS B
- ------------------------------------------  -------------------  ------------  ------------
<S>                                         <C>                  <C>           <C>
Asian Equity                                         0.80%             1.00%         1.25%
Japanese Equity                                      0.80%             1.00%         1.25%
</TABLE>
 
                                       20
<PAGE>
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to customers in the
United States and abroad. Morgan Stanley Dean Witter & Co. ("MSDW") is the
parent of the Adviser and Morgan Stanley. MSDW is a preeminent global financial
services firm that maintains leading market positions in each of its three
primary businesses -- securities, asset management and credit services. At March
31, 1998, the Adviser, together with its affiliated institutional asset
management companies, managed assets of approximately $166 billion, including
assets under fiduciary advice. See "Management of the Fund" in the Statement of
Additional Information.
 
    PORTFOLIO MANAGERS.  The following individuals have primary portfolio
management responsibility for the Portfolios noted below:
 
    ASIAN EQUITY PORTFOLIO -- VINOD SETHI. Vinod Sethi joined the Adviser in
1989 and since then, has been actively involved in the Adviser's emerging market
group. Mr. Sethi is a Managing Director of Morgan Stanley and the Adviser and is
the Adviser's Chief Investment Officer for the Asian region. He received his
undergraduate degree in Chemical Engineering from I.I.T. (Bombay) and his M.B.A.
from New York University School of Business.
 
    JAPANESE EQUITY PORTFOLIO -- JOHN R. ALKIRE AND KUNIHIKO SUGIO. John R.
Alkire is a Managing Director of Morgan Stanley and the Adviser. He has been
primarily responsible for managing the Portfolio's assets since June 1997. Mr.
Alkire joined the Adviser in 1981 to initiate foreign equity sales and trading
to Pacific basin institutions. He was appointed President of Morgan Stanley
Investment Advisory, Japan in October 1993. Prior to 1993, he specialized in
Japanese warrants and cash equity sales and trading to Japanese financial
institutions in the Tokyo office. Mr. Alkire is a graduate of University of
Victoria Canada. Kunihiko Sugio, a Principal of Morgan Stanley and the Adviser,
joined the Adviser in December 1993 and manages dedicated Japanese equity
portfolios. He has been primarily responsible for managing the Portfolio's
assets since its inception. Prior to joining the Adviser, he worked with Baring
International Investment Management, Tokyo, where he was a Director and fund
manager. He graduated from Wakayama Kokuritsu University.
 
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the officers and
Board of Directors of the Fund and include day-to-day administration of matters
related to the corporate existence of the Fund, maintenance of its records,
preparation of reports, supervision of the Fund's arrangements with its
custodian and assistance in the preparation of the Fund's registration
statements under federal laws. The Administration Agreement also provides that
the Administrator, through its agents, will provide dividend disbursing and
transfer agent services to the Fund. For its services under the Administration
Agreement, the Fund pays the Adviser a monthly fee which on an annual basis
equals 0.15% of the average daily net assets of each Portfolio.
 
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors such administrative services provided by CGFSC.
Their services are also subject to the supervision of the Board of Directors of
the Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
                                       21
<PAGE>
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of each Portfolio upon the terms and at the current
offering price described in this Prospectus. Morgan Stanley is not obligated to
sell any certain number of shares of any Portfolio.
 
    The Portfolios currently offer only the classes of shares offered by this
Prospectus. The Portfolios may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares of each Portfolio pursuant to Rule 12b-1 under the 1940 Act (each, a
"Plan"). Under each Plan, the Distributor is entitled to receive from each
Portfolio a distribution fee, which is accrued daily and paid quarterly, of
0.25% of the Class B shares' average daily net assets on an annualized basis.
Each Plan is designed to compensate the Distributor for its services in
connection with distribution assistance. The Distributor may retain any portion
of the fee that it does not expend in meeting its obligations to the Fund. The
Distributor may compensate financial intermediaries, plan fiduciaries and
administrators for providing distribution-related services, including account
maintenance services, to shareholders (including, where applicable, underlying
beneficial owners) of Class B shares.
 
    EXPENSES.  Each Portfolio is responsible for payment of certain other fees
and expenses (including legal fees, accountant's fees, custodial fees and
printing and mailing costs) as specified in its agreements with the Adviser and
Morgan Stanley.
 
    YEAR 2000.  The management and distribution services provided to the Fund by
the Adviser and Morgan Stanley depend on the smooth functioning of their
computer systems. Many computer software systems in use today cannot recognize
the year 2000, but revert to 1900 or some other date, due to the manner in which
dates were encoded and calculated. That failure could have a negative impact on
the handling of securities trades, pricing and account services. The Adviser and
Morgan Stanley have been actively working on necessary changes to their own
computer systems to deal with the year 2000 problem and expect that their
systems will be adapted before that date. There can be no assurance, however,
that they will be successful. In addition, other unaffiliated service providers
may be faced with similar problems. The Adviser and Morgan Stanley are
monitoring their remedial efforts, however, there can be no assurance that they
and the services they provide will not be adversely affected.
 
    In addition, it is possible that the markets for securities in which the
Portfolios invest may be detrimentally affected by computer failures throughout
the financial services industry beginning January 1, 2000. Improperly
functioning trading systems may result in settlement problems and liquidity
issues. In addition, corporate and governmental data processing errors may
result in production problems for individual companies and overall economic
uncertainties. Earnings of individual issuers will be affected by remediation
costs, which may be substantial and may be reported inconsistently in U.S. and
foreign financial statements. Accordingly, the Portfolios' investments may be
adversely affected.
 
                                       22
<PAGE>
                               PURCHASE OF SHARES
 
    Class A shares of each Portfolio and Class B shares of each Portfolio may be
purchased at the net asset value per share next determined after receipt by the
Fund of a purchase order as described under "Methods of Purchase." The net asset
value per share of each Portfolio is calculated on days that the New York Stock
Exchange ("NYSE") and Chase (the "Custodian Bank") are open for business as of
the close of trading of the NYSE, normally 4:00 p.m. Eastern Time (the "Pricing
Time").
 
MINIMUM INVESTMENT
 
    The minimum initial investment is $500,000 for Class A shares and $100,000
for Class B shares of each Portfolio. These minimums may be waived at the
discretion of the Adviser for certain types of investors, including trust
departments, brokers, dealers, agents, financial planners, financial services
firms, investment advisers or various retirement and deferred compensation plans
("Financial Intermediaries"), certain accounts managed by the Adviser and its
affiliates ("Managed Accounts"), and certain employees and customers of Morgan
Stanley and its affiliates. The Fund's determination of an investor's
eligibility to purchase shares of a given class will take precedence over the
investor's selection of a class.
 
METHODS OF PURCHASE
 
    Shares may be purchased directly from the Fund by Federal Funds wire, by
bank wire or by check. Investors may also invest in the Portfolios by purchasing
shares through Financial Intermediaries that have made arrangements with Morgan
Stanley. Some Financial Intermediaries may charge an additional service or
transaction fee. If a purchase is canceled due to nonpayment or because your
check does not clear, you will be responsible for any loss the Fund or its
agents incur. If you are already a shareholder, the Fund may redeem shares from
your account(s) to reimburse the Fund or its agents for any loss. In addition,
you may be prohibited or restricted from making future investments in the Fund.
 
    FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire Federal
Funds to the Fund's bank account. Federal Funds purchase orders will be accepted
only on a day on which the Fund and the Custodian Bank are open for business.
Your bank may charge a service fee for wiring Federal Funds. In order to ensure
proper handling of your purchase by Federal Funds wire, please follow these
steps:
 
    1.  Place your order by telephoning the Fund at 1-800-548-7786. A Fund
       representative will request certain purchase information and provide you
       with a confirmation number.
 
    2.  Instruct your bank to wire the specified amount to the Fund's Wire
        Concentration Bank Account as follows:
       The Chase Manhattan Bank
       One Manhattan Plaza
       New York, NY 10081-1000
       ABA# 021000021
       DDA# 910-2-733293
       Attn: Morgan Stanley Institutional Fund, Inc.
       Ref: (Portfolio name, your account number, your account name)
       Please call the Fund at 1-800-548-7786 prior to wiring the funds.
 
                                       23
<PAGE>
    3.  Complete and sign the Account Registration Form and mail it to the
       address shown thereon.
 
    When a purchase order is received prior to the Pricing Time and Federal
Funds are received prior to the close of the Federal Funds Wire Control Center
("FFWCC") (normally 6:00 p.m. Eastern Time), the purchase will be executed at
the net asset value computed on the date of receipt. Purchases for which an
order is received after the Pricing Time or for which Federal Funds are received
after the close of the FFWCC, will be executed at the net asset value next
determined. Certain institutional investors and financial institutions have
entered into an arrangement with Morgan Stanley, pursuant to which they may
place orders prior to the Pricing Time, but make payment in Federal Funds for
those shares on the following business day.
 
    BANK WIRE.  A purchase of shares by bank wire must follow the same procedure
as for a Federal Funds wire, described above. However, depending on the time the
bank wire is sent and which bank is handling the wire, money transferred by bank
wire may or may not be converted into Federal Funds prior to the close of the
FFWCC. Prior to conversion to Federal Funds and receipt by the Fund, an
investor's money will not be invested.
 
    CHECK.  An account may be opened by completing and signing an Account
Registration Form and mailing it, together with a check payable to "Morgan
Stanley Institutional Fund, Inc. -[portfolio name]" to:
 
       Morgan Stanley Institutional Fund, Inc.
       P.O. Box 2798
       Boston, Massachusetts 02208-2798
 
    The Fund ordinarily is credited with Federal Funds within one business day
of deposit of a check. Thus, a purchase of shares by check ordinarily will be
credited to your account at the net asset value per share of each of the
Portfolios determined on the next business day after receipt. An investor's
money will not be invested prior to crediting of Federal Funds.
 
    INVESTMENT THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to receive purchase and
redemption orders from underlying beneficial owners, such as retirement plan
participants, generally on each business day. Each business evening, the
Financial Intermediary aggregates all orders received from underlying beneficial
owners prior to the Pricing Time on that business day and places a net purchase
and/or redemption order(s) by the morning of the next business day. These orders
normally are executed at the net asset value that was computed for each
Portfolio as of the close of the previous business day.
 
    ADDITIONAL INVESTMENTS.  You may purchase additional shares for your account
at any time by purchasing shares at net asset value by any of the methods
described above. The minimum additional investment generally is $1,000 per
Portfolio. The minimum additional investment may be lower for certain accounts,
described above under "Minimum Investment." For purchases directly from the
Fund, your account name, the Portfolio name and the class selected must be
specified in the letter or wire to assure proper crediting to your account.
 
INVOLUNTARY CONVERSION AND REDEMPTION OF NEW ACCOUNT SHARES
 
    Class A and Class B shares of each Portfolio may be subject to the
involuntary conversion and redemption features described below. The conversion
and redemption features may be waived at the discretion of the Adviser for
shares held in a Managed Account and shares purchased through a Financial
Intermediary. Accounts
 
                                       24
<PAGE>
that were open prior to January 2, 1996 are not subject to involuntary
conversion or redemption. The Fund reserves the right to modify or terminate the
conversion or redemption features of the shares at any time upon 60 days notice
to shareholders.
 
    CONVERSION FROM CLASS A TO CLASS B SHARES.  If the value of an account
containing Class A shares falls below $500,000 (but remains at or above
$100,000) because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $500,000 (but remains at or
above $100,000) for a continuous 60-day period, the Class A shares in such
account will convert to Class B shares and will be subject to the distribution
fee and other features applicable to Class B shares. The Fund will not convert
Class A shares to Class B shares based solely upon changes in the market that
reduce the net asset value of shares. Under current tax law, conversion between
share classes is not a taxable event to the shareholder.
 
    CONVERSION FROM CLASS B TO CLASS A SHARES.  If the value of an account
containing Class B shares increases to $500,000 or more, whether due to
shareholder purchases or market activity, the Class B shares will convert to
Class A shares. Class B shares purchased through a Financial Intermediary that
has entered into an arrangement with the Fund for the purchase of such shares
may not be converted. Under current tax law, such conversion is not a taxable
event to the shareholder. Class A shares converted from Class B shares are
subject to the same minimum account size requirements as are applicable to New
Accounts containing Class A shares described above.
 
    INVOLUNTARY REDEMPTION OF SHARES.  If the value of an account falls below
$100,000 because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $100,000 for a continuous
60-day period, the shares in such account will be subject to redemption by the
Fund. The Fund will not redeem shares based solely upon changes in the market
that reduce the net asset value of shares. If redeemed, redemption proceeds will
be promptly paid to the shareholder.
 
                              REDEMPTION OF SHARES
 
    Class A and Class B shares of each Portfolio may be redeemed at any time and
without charge at the net asset value per share next determined after receipt by
the Fund of a redemption order as described under "Methods of Redemption."
Redemption proceeds may be more or less than the purchase price of your shares
depending on, among other factors, the market value of the investment securities
held by a Portfolio.
 
METHODS OF REDEMPTION
 
    Shares may be redeemed directly from the Fund by mail or by telephone.
However, shares purchased through a Financial Intermediary must be redeemed
through a Financial Intermediary. Certain Financial Intermediaries may charge an
additional service or transaction fee.
 
    BY MAIL.  Each Portfolio will redeem shares upon receipt of a redemption
request in "good order." Redemption requests may be sent by regular mail to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798 or, by overnight courier, to Morgan Stanley Institutional Fund, Inc.,
c/o Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913.
 
    "Good order" means that the request to redeem shares must include the
following:
 
                                       25
<PAGE>
    1.  A letter of instruction or a stock assignment specifying the class and
       number of shares or dollar amount to be redeemed, signed by all
       registered owners of the shares in the exact names in which they are
       registered;
 
    2.  Any required signature guarantees; and
 
    3.  Other supporting legal documents, if required, in the case of estates,
       trusts, guardianships, custodianships, corporations, pension and
       profit-sharing plans and other organizations.
 
    Redemption requests received in "good order" prior to the Pricing Time will
be executed at the net asset value computed on the date of receipt. Redemption
requests received after the Pricing Time will be executed at the next determined
net asset value. Shareholders who are uncertain of requirements for redemption
by mail should consult with a Fund representative.
 
    BY TELEPHONE.  If you have previously elected the Telephone Redemption
Option on the Account Registration Form, you can redeem Portfolio shares by
calling the Fund and requesting that the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. To change the commercial bank or account designated to receive
redemption proceeds, send a written request to the Fund at the address above.
Requests to change the bank or account must be signed by each shareholder and
each signature must be guaranteed. The telephone redemption option may be
difficult to implement at times, particularly during volatile market conditions.
If you experience difficulty in making a telephone redemption, you may redeem
shares by mail as described above.
 
    The Fund and the Transfer Agent will employ reasonable procedures to confirm
that instructions communicated by telephone are genuine. An investor may be
required to provide personal identification information at the time an account
is opened and prior to effecting each telephone transaction. In addition, all
telephone transaction requests will be recorded and investors may be required to
provide additional telecopied written instructions regarding transaction
requests. Neither the Fund nor the Transfer Agent will be responsible for any
loss, liability, cost or expense for following instructions received by
telephone that either of them reasonably believes to be genuine.
 
    REDEMPTION THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to accept redemption
requests from underlying beneficial owners. These redemptions may be processed
in the same way as purchases made through such Financial Intermediaries, as
described above.
 
FURTHER REDEMPTION INFORMATION
 
    The Fund normally makes payment for all shares redeemed within one business
day of receipt of the request, and in no event more than seven days after
receipt of a redemption request in good order. However, payments to investors
redeeming shares which were purchased by check will not be made until payment
for the purchase has been collected, which may take up to eight days after the
date of purchase. The Fund may suspend the right of redemption or postpone the
date upon which redemptions are effected at times when the NYSE is closed, or
under any emergency conditions as determined by the Securities and Exchange
Commission (the "Commission").
 
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of a Portfolio to make payment in
cash, the Fund may pay redemption proceeds in whole or in part
 
                                       26
<PAGE>
by a distribution-in-kind of readily marketable portfolio securities in
accordance with applicable rules of the Commission. Shareholders may incur
brokerage charges on the sale of portfolio securities received in payment of
redemptions.
 
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required to verify the identity of the person who has authorized
certain redemptions. Please contact the Fund or see the Statement of Additional
Information for further information.
 
                         ACCOUNT POLICIES AND SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares of each Portfolio that you own for shares of any
other available portfolio(s) of the Fund, subject to certain limitations. You
cannot exchange for shares of the International Equity, Emerging Markets, Small
Cap Value Equity, Balanced or Gold Portfolios because they are currently closed
to new investors. In addition, certain portfolios may be unavailable to
shareholders who purchased portfolio shares through a Financial Intermediary.
Contact your Financial Intermediary to determine which portfolios are available
for exchange.
 
    Before you make an exchange, you should read the prospectus of the
portfolio(s) in which you seek to invest. The class of shares you receive in the
exchange will be determined in the same manner as any other purchase of shares,
including minimum initial investment and account size requirements, and will not
be based on the class of shares you surrender for the exchange. Exchange
transactions are treated as a redemption followed by a purchase. Therefore, an
exchange will be considered a taxable event for shareholders subject to tax.
Exchange transactions will be processed at the net asset value per share next
determined after receipt of the request. Shares of the portfolios may be
exchanged by mail or telephone. The telephone exchange privilege is automatic
and made available without shareholder election. The exchange privilege may be
modified or terminated by the Fund at any time upon 60-days notice to
shareholders.
 
    BY MAIL.  To exchange shares by mail, send a written exchange request to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798. Your written exchange request should include (i) the name, class of
shares and account number of your current Portfolio; (ii) the name(s) and
class(es) of shares of the portfolio(s) into which you intend to exchange
shares; and (iii) the signatures of all registered account holders.
 
    BY TELEPHONE.  To exchange shares by telephone, call the Fund at the phone
number provided on the cover of this Prospectus. A Fund representative will
request (i) the name, class of shares and account number of your current
Portfolio, and (ii) the name(s) and class(es) of shares of the portfolio(s) into
which you intend to exchange shares. For additional information regarding
responsibility for the authenticity of telephoned instructions, see "Redemption
of Shares" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by sending a written request to Morgan Stanley Institutional Fund, Inc.,
P.O. Box 2798, Boston, Massachusetts 02208-2798. It may not be possible to
transfer the registration of certain shares purchased through a Financial
Intermediary. As with
 
                                       27
<PAGE>
redemptions, the written request must be received in "good order" before any
transfer can be made. Transferring the registration of shares may affect the
eligibility of your account for a given class of shares and may result in
involuntary conversion or redemption of your shares.
 
OTHER ACCOUNT INFORMATION
 
    The Fund does not issue share certificates for the Portfolios. All shares
purchased are confirmed to you and credited to your account on the Fund's books
maintained by the Adviser or its agents. You will have the same rights and
ownership with respect to such shares as if certificates had been issued.
 
EXCESSIVE TRADING
 
    Frequent trades in your account(s) can disrupt management of a Portfolio and
raise its expenses. Consequently, the Fund may, in its discretion and in the
interest of each Portfolio's shareholders and performance, bar a shareholder who
trades excessively from making further share purchases for an indefinite period.
The Fund considers excessive trading to be more than one purchase and sale
involving shares of the same class of a portfolio of the Fund within any 120-day
period. For example, the following series of transactions would amount to
excessive trading: exchanging shares of Portfolio A for shares of Portfolio B,
then exchanging shares of Portfolio B for shares of Portfolio C and then
exchanging shares of Portfolio C for shares of Portfolio A within a 120-day
period. Two types of transactions are exempt from these excessive trading
restrictions: (i) trades exclusively between money market portfolios, and (ii)
trades made in connection with an asset allocation service managed or advised by
the Adviser and/or any of its affiliates.
 
INVESTMENT IN PORTFOLIOS BY OTHER INVESTMENT ACCOUNTS
 
    Morgan Stanley or its affiliates, including Morgan Stanley Asset Management
Inc., manage investment accounts for other clients, including other investment
companies, that invest in Class A or Class B shares of the portfolios. From time
to time, one or more of the Portfolios used for investment by these accounts may
experience relatively large investments or redemptions due to investment
decisions made on behalf of these accounts. These transactions will affect the
portfolios, since portfolios that experience significant redemptions may have to
sell portfolio securities and portfolios that receive additional cash will have
to invest it in additional portfolio securities. It is impossible to predict the
overall impact of these transactions over time, however, there could be adverse
effects on portfolio management. These transactions also could have tax
consequences if sales of portfolio securities result in gains or could increase
transaction costs. The Adviser, representing the interests of the portfolios, is
committed to minimizing the impact of these transactions to the portfolios. The
Adviser, however, will have a conflict in fulfilling this responsibility in that
it also advises these investment accounts. The Adviser will monitor the impact
of these transactions on the Portfolios.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of each of the Portfolios
is determined by dividing the total market value of the Portfolio's investments
and other assets attributable to such class, less any liabilities attributable
to such class, by the total number of outstanding shares of each class of the
Portfolio. Net asset value is calculated separately for each class of the
Portfolios. Net asset value per share is determined as of the close of the NYSE
(normally 4:00 p.m. Eastern Time) on each day that the NYSE is open for
business. Price information on listed securities is taken from the exchange
where the security is primarily traded. Securities listed on a U.S. securities
exchange for which market quotations are available are valued at the last quoted
sale price on the day
 
                                       28
<PAGE>
the valuation is made. Securities listed on a foreign exchange are valued at
their closing price. Unlisted securities and listed securities not traded on the
valuation date and for which market quotations are not readily available are
valued at a price within a range not exceeding the current asked price nor less
than the current bid price. The current bid and asked prices are determined
based on the average of the bid and asked prices quoted on such valuation date
by reputable brokers.
 
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily. In addition, bonds and other fixed income securities may be
valued on the basis of prices provided by a pricing service when such prices are
believed to reflect the fair market value of such securities. The prices
provided by a pricing service are determined without regard to bid or last sale
prices but take into account institutional size trading in similar groups of
securities and any developments related to the specific securities. Securities
not priced in this manner are valued at the most recently quoted bid price or,
when securities exchange valuations are used, at the latest quoted sale price on
the day of valuation. If there is no such reported sale, the latest quoted bid
price will be used. Securities purchased with remaining maturities of 60 days or
less are valued at amortized cost, if it approximates market value. In the event
that amortized cost does not approximate market value, market prices as
determined above will be used.
 
    The value of other assets and securities for which quotations are not
readily available (including restricted and unlisted foreign securities) and
those securities for which it is inappropriate to determine the prices in
accordance with the above-stated procedures are determined in good faith at fair
value using methods determined by the Board of Directors. For purposes of
calculating net asset value per share, all assets and liabilities initially
expressed in foreign currencies will be translated into U.S. dollars at the mean
of the bid and asked price for such currencies against the U.S. dollar last
quoted by a major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distribution expense accrual differential among the classes. The
net asset value of Class B shares will generally be lower than the net asset
value of the Class A shares as a result of the distribution expenses charged to
Class B shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise the "total return" for each class
of a Portfolio. THESE FIGURES ARE BASED ON HISTORICAL EARNINGS AND ARE NOT
INTENDED TO INDICATE FUTURE PERFORMANCE.
 
    Each of the Portfolios may advertise "total return" which shows what an
investment in a class of a Portfolio would have earned over a specified period
of time (such as one, five or ten years) assuming that all distributions and
dividends by the Portfolio were reinvested in the same class on the reinvestment
dates during the period. Total return does not take into account any federal or
state income taxes that may be payable on dividends and distributions or on
redemption. The Fund may also include comparative performance information in
advertising or marketing the Portfolios' shares, including data from Lipper
Analytical Services, Inc., other industry publications, business periodicals,
rating services and market indices.
 
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                                       29
<PAGE>
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains distributions for a class of shares
will be automatically reinvested in additional shares at net asset value, except
when, upon written notice to the Fund or by checking off the appropriate box in
the Distribution Option Section on the Account Registration Form, a shareholder
elects to receive income dividends and capital gains distributions in cash.
 
    Each Portfolio expects to distribute substantially all of its taxable net
investment income in the form of annual dividends. Net realized capital gains,
if any, after reduction for any available tax loss carryforwards will also be
distributed annually.
 
    Undistributed net investment income is included in a Portfolio's net assets
for the purpose of calculating net asset value per share. Therefore, on the
"ex-dividend" date, the net asset value per share excludes the dividend (i.e.,
is reduced by the per share amount of the dividend). Dividends paid shortly
after the purchase of shares by an investor, although in effect a return of
capital, are taxable to shareholders subject to income tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of the Portfolios will differ at times.
Expenses of the Portfolios allocated to a particular class of shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of the Portfolios or their shareholders.
Accordingly, shareholders are urged to consult their tax advisers regarding
specific questions as to federal, state and local income taxes.
 
    Each Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other portfolios. Each Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Internal Revenue Code of 1986, as amended
(the "Code"), so that the Portfolio will be relieved of federal income tax on
that part of its net investment income and net capital gain that is distributed
to shareholders.
 
    Each Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, net short-term capital gain) to
shareholders. Dividends from a Portfolio's net investment income are taxable to
shareholders as ordinary income, whether received in cash or in additional
shares. Such dividends paid by a Portfolio will generally not qualify for the
dividends-received deduction for corporate shareholders. Each Portfolio will
report annually to its shareholders the amount of dividend income qualifying for
such treatment.
 
    Distributions of net capital gain are taxable to shareholders as a 20% rate
gain distribution (taxed at a rate of 20%) or a 28% rate gain distribution
(taxed at a rate of 28%), depending upon the designation by the Portfolio
 
                                       30
<PAGE>
(such designation being dependent upon the holding period of the Portfolio in
the underlying asset generating the net capital gain), regardless of how long
shareholders have held their shares. Each Portfolio will send reports annually
to its shareholders of the federal income tax status of all distributions made
during the preceding year.
 
    Each Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gain over short-term and long-term capital
loss, including any available capital loss carryforwards) prior to the end of
each calendar year to avoid liability for federal excise tax.
 
    Dividends and other distributions declared by a Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders in that year if the distributions are paid by the Portfolio at
any time during the following January.
 
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any dividends, capital gains distributions and redemption proceeds paid to any
individual or certain other non-corporate shareholder (i) who has failed to
provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Account Registration Form; (ii) who is subject to backup withholding by the
Internal Revenue Service; or (iii) who has not certified to the Fund that such
shareholder is not subject to backup withholding. This backup withholding is not
an additional tax, and any amounts withheld may be credited against the
shareholder's ultimate U.S. tax liability.
 
    The sale, exchange or redemption of shares will result in taxable gain or
loss to the selling, exchanging or redeeming shareholder, depending upon whether
the fair market value of the sale, exchange or redemption proceeds exceed or are
less than the shareholder's adjusted tax basis in the sold, exchanged or
redeemed shares. If capital gains distributions have been made with respect to
shares that are sold at a loss after being held for six months or less, then the
loss is treated as a long-term capital loss to the extent of the capital gains
distributions.
 
    Conversions of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisors concerning the
application of state and local income taxes to investments in a Portfolio, which
may differ from the federal income tax consequences described above.
 
    Investment income received by a Portfolio from sources within foreign
countries may be subject to foreign income taxes withheld at the source. To the
extent that a Portfolio is liable for foreign income taxes so withheld, each
Portfolio intends to operate so as to meet the requirements of the Code to pass
through to the shareholders credit for foreign income taxes paid. Although each
Portfolio intends to meet Code requirements to pass through credit for such
taxes, there can be no assurance that each Portfolio will be able to do so.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN A PORTFOLIO.
 
                                       31
<PAGE>
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolio
for their clients.
 
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other remuneration paid to Morgan Stanley or other affiliates must be
fair and reasonable in comparison to those of other broker-dealers for
comparable transactions involving similar securities being purchased or sold
during a comparable time period.
 
PORTFOLIO TURNOVER
 
    The Portfolios generally do not invest for short-term trading purposes,
however, when circumstances warrant, each Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolios will not consider portfolio turnover rate
a limiting factor in making investment decisions consistent with their
respective objectives and policies. For the fiscal year ended December 31, 1997,
the Asian Equity Portfolio had a portfolio turnover rate of 107%. Higher
portfolio turnover (e.g., over 100%) necessarily will cause the Portfolios to
pay correspondingly increased brokerage and trading costs. In addition to
transaction costs, higher portfolio turnover may result in the realization of
capital gains. As discussed under "Taxes," to the extent net short-term capital
gains are realized, any distributions resulting from such gains are considered
ordinary income for federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 40 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of each
Portfolio are currently classified into two classes, the Class A shares and the
Class B shares.
 
    The shares of each Portfolio, when issued, will be fully paid,
nonassessable, fully transferable and redeemable at the option of the holder.
The shares have no preference as to conversion, exchange, dividends, retirement
 
                                       32
<PAGE>
or other features and have no pre-emptive rights. The shares of each Portfolio
have non-cumulative voting rights, which means that the holders of more than 50%
of the shares voting for the election of Directors can elect 100% of the
Directors if they choose to do so. Persons or organizations owning 25% or more
of the outstanding shares of a Portfolio may be presumed to "control" (as
defined in the 1940 Act) such Portfolio. Under Maryland law, the Fund is not
required to hold an annual meeting of its shareholders unless required to do so
under the 1940 Act.
 
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual and semi-annual reports. The
financial statements appearing in annual reports are audited by independent
accountants. Monthly unaudited portfolio data is also available from the Fund
upon request.
 
    In addition, the Adviser or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
CUSTODIAN
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs sub-custodians approved by the Board of Directors of the Fund
in accordance with regulations of the Commission for the purpose of providing
custodial services for such assets. MSTC may also hold certain domestic assets
for the Fund. For more information on the custodians, see "General Information
- -- Custody Arrangements" in the Statement of Additional Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits its annual financial statements.
 
FUND COUNSEL
 
    Morgan, Lewis & Bockius LLP acts as the Fund's legal counsel.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       33
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
  ASIAN EQUITY AND JAPANESE EQUITY PORTFOLIOS
   P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                            <C>
      ACCOUNT INFORMATION                            If you need assistance in filling out this form for the Morgan Stanley
      Fill in where applicable                       Institutional Fund, Inc., please contact your Morgan Stanley
                                                     representative or call us toll free 1-800-548-7786. Please print all
                                                     items except signature, and mail to the Fund at the address above.
 
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
         TENANCY IN COMMON
         IS INDICATED)
</TABLE>
 
1.
         First Name    Initial         Last Name
 
2.
         First Name    Initial         Last Name
 
         First Name    Initial         Last Name
 
<TABLE>
<C>   <S>                                            <C>
      3. CORPORATIONS,
         TRUSTS AND OTHERS
         Please call the Fund for additional
      documents that may be required to set up
      account and to authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                     <C>                 <C>                   <C>               <C>
Type of Registration:   / / INCORPORATED    / / UNINCORPORATED    / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                            ASSOCIATION                               (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
 
<TABLE>
<C>   <S>                                            <C>
  B)  MAILING ADDRESS
      Please fill in completely, including
      telephone number(s).
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
 
/ / Non-Resident Alien
 
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
 
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
 
<TABLE>
<C>   <S>                                            <C>                                  <C>
  C)  TAXPAYER                                       Enter your Taxpayer Identification Number. For most individual
      IDENTIFICATION                                 taxpayers, this is your Social Security Number.
      NUMBER
      1. INDIVIDUAL
      2.   JOINT TENANTS
           (RIGHTS OF SURVIVORSHIP PRESUMED UNLESS
           TENANCY IN COMMON
           IS INDICATED)
      For Custodian account
      of a minor (Uniform
      Gifts/Transfers to Minor
      Acts), give the Social
      Security Number of
      the minor.
</TABLE>
<PAGE>
<TABLE>
<C>   <S>                                            <C>                                  <C>
                                                                                          OR
                                                     1.         TAXPAYER IDENTIFICATION                      SOCIAL SECURITY
                                                     NUMBER ("TIN")                                NUMBER ("SSN")
                                                                                              OR
                                                     2.                             TIN
                                                                                                                             SSN
                                                                                              OR
                                                     TIN
                                                                                                                             SSN
 
                                                     IMPORTANT TAX INFORMATION
                                                     You (as a payee) are required by law to provide us (as payer) with your
                                                     correct TIN(s) or SSN(s). Accounts that have a missing or incorrect
                                                     TIN(s) or SSN(s) will be subject to backup withholding at a 31% rate on
                                                     dividends, distributions and other payments. If you have not provided us
                                                     with your correct TIN(s) or SSN(s), you may be subject to a $50 penalty
                                                     imposed by the Internal Revenue Service.
                                                     Backup withholding is not an additional tax; the tax liability of
                                                     persons subject to backup withholding will be reduced by the amount of
                                                     tax withheld. If withholding results in an overpayment of taxes, a
                                                     refund may be obtained.
                                                     You may be notified that you are subject to backup withholding under
                                                     Section 3406(a)(1)(C) of the Internal Revenue Code because you have
                                                     underreported interest or dividends or you were required to, but failed
                                                     to, file a return which would have included a reportable interest or
                                                     dividend payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                                  <C>                             <C>                   <C>
  D)  PORTFOLIO AND                        For Purchase of the following   / / Class A Shares $  / / Class B Shares $
      CLASS SECTION                        Portfolio(s):                   / / Class A Shares $  / / Class B Shares $
      (Class A shares minimum $500,000     Asian Equity Portfolio
      for each Portfolio and Class B       Japanese Equity Portfolio
      shares minimum $100,000 for each
      Portfolio). Please indicate
      Portfolio, class and amount.
                                                                           Total Initial Investment $
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate portfolio
      and manner of payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                          <C>
/ / Exchange $ From                                                                     - - - - - - - - - - - -- - -
                            Name of Portfolio                                                   Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on                 -- - - - - - - - - - -- - -
                                                                                      Account No.               (Check
                                                                                (Previously assigned by the Fund)     Digit)
                                                                                                                          Date
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  F)  DISTRIBUTION               Income dividends and capital gains distributions (if any) to
      OPTION                     be reinvested in additional shares unless either box below
                                 is checked.
                                 / / Income dividends to be paid in cash, capital gains
                                 distributions (if any) in shares.
                                 / / Income dividends and capital gains distributions (if
                                 any) to be paid in cash.
</TABLE>
 
<TABLE>
<C>   <S>                             <C>                                       <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone         Name of COMMERCIAL Bank (Not Savings
      AND EXCHANGE                    requests to wire redemption proceeds to   Bank)
      OPTION                          the commercial bank indicated at right    Bank Account No.
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund
      wish to redeem or exchange      account is registered if such requests                                        Bank
      shares by telephone. A          are believed to be authentic.                                                  ABA
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent                                         No.
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated    Name(s) in which your Bank Account is
      YOUR FUND ACCOUNT.              by telephone are genuine. These           Established
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal      Bank's Street
      NOT BE HONORED UNLESS THE BOX   identification information at the time    Address
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by   City  State  Zip
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  H)  INTERESTED PARTY
      OPTION                                                                                                Name
      In addition to the account
      statement sent to my/our registered
      address, I/we hereby authorize the                                                                   Address
      Fund to mail duplicate statements
      to the name and address provided at  City         State         Zip Code
      right.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  I)  DEALER
      INFORMATION
                                           Representative Name              Representative No.             Branch
                                           No.
</TABLE>
 
<TABLE>
<C>   <S>                                  <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here ,
</TABLE>
 
<TABLE>
<S>                                  <C>
The undersigned certify that I/we have full authority and legal capacity
to purchase and redeem shares of the Fund and affirm that I/we have
received a current Prospectus of the Morgan Stanley Institutional Fund,
Inc. and agree to be bound by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF
PERJURY THAT THE INFORMATION ON THIS APPLICATION IS COMPLETE AND CORRECT
AND THAT AS REQUIRED BY FEDERAL LAW (PLEASE CHECK APPLICABLE BOXES
BELOW):
 
/ / U.S. CITIZEN(S)/TAXPAYER(S):
 
      / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM
          IS/ARE THE CORRECT SSN(S) OR TIN(S) AND (2) I/WE ARE NOT
          SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE ARE
          EXEMPT FROM BACKUP WITHHOLDING; (B) I/WE HAVE NOT BEEN
          NOTIFIED BY THE INTERNAL REVENUE SERVICE ("IRS") THAT I/WE ARE
          SUBJECT TO BACKUP WITHHOLDING AS A RESULT OF A FAILURE TO
          REPORT ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED
          ME/US THAT I AM/WE ARE NO LONGER SUBJECT TO BACKUP
          WITHHOLDING.
 
      / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE HAVE
          APPLIED, OR INTEND TO APPLY, TO THE IRS OR THE SOCIAL SECURITY
          ADMINISTRATION FOR A TIN OR A SSN AND I/WE UNDERSTAND THAT IF
          I/ WE DO NOT PROVIDE EITHER NUMBER TO CHASE GLOBAL FUNDS
          SERVICES COMPANY ("CGFSC") WITHIN 60 DAYS OF THE DATE OF THIS
          APPLICATION OR IF I/WE FAIL TO FURNISH MY/OUR CORRECT SSN(S)
          OR TIN(S), I/WE MAY BE SUBJECT TO A PENALTY AND A 31% BACKUP
          WITHHOLDING ON DISTRIBUTIONS AND REDEMPTION PROCEEDS. (PLEASE
          PROVIDE EITHER NUMBER ON IRS FORM W-9). YOU MAY REQUEST SUCH
          FORM BY CALLING CGFSC AT 800-282-4404.
 
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
  UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S.
CITIZENS OR RESIDENTS AND I/WE ARE EXEMPT FOREIGN PERSONS AS DEFINED BY
THE INTERNAL REVENUE SERVICE.
 
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY
PROVISION OF THIS DOCUMENT OTHER THAN THE CERTIFICATIONS REQUIRED TO
AVOID BACKUP WITHHOLDING.
 
                                     (X)
(X)                                  Signature (if joint account, both
Signature            Date            must sign)      Date
</TABLE>
 
<PAGE>
<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<CAPTION>
                                                    PAGE
                                                    ----
<S>                                                 <C>
Fund Expenses.....................................    2
Financial Highlights..............................    4
Prospectus Summary................................    7
Investment Objectives and Policies................   11
Additional Investment Information.................   12
Investment Limitations............................   20
Management of the Fund............................   20
Purchase of Shares................................   23
Redemption of Shares..............................   25
Account Policies and Services.....................   27
Valuation of Shares...............................   28
Performance Information...........................   29
Dividends and Capital Gains Distributions.........   30
Taxes.............................................   30
Portfolio Transactions............................   32
General Information...............................   32
Account Registration Form
</TABLE>
 
                             ASIAN EQUITY PORTFOLIO
                           JAPANESE EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
 
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  Incorporated
 
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                      P.O. BOX 2798, BOSTON, MA 02208-2798
 
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
<PAGE>
- --------------------------------------------------------------------------------
                              P R O S P E C T U S
     ----------------------------------------------------------------------
 
                           U.S. EQUITY PLUS PORTFOLIO
 
                               A PORTFOLIO OF THE
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                P.O. BOX 2798, BOSTON, MASSACHUSETTS 02208-2798
                      FOR INFORMATION CALL 1-800-548-7786
 
                                ----------------
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company, or mutual fund, which offers redeemable shares in
a series of diversified and nondiversified investment portfolios ("portfolios").
The Fund is designed to provide clients with attractive alternatives for meeting
their investment needs. The Fund currently consists of thirty-two portfolios
representing a broad range of investment choices. This prospectus (the
"Prospectus") pertains to the Class A and Class B shares of the U.S. Equity Plus
Portfolio (the "Portfolio"). The Class A and Class B shares currently offered by
the Portfolio have different minimum investment requirements and fund expenses.
Shares of the Portfolio are offered with no sales charge, exchange fee or
redemption fee.
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser and Administrator (the "Adviser" and the
"Administrator"), and with Morgan Stanley & Co. Incorporated ("Morgan Stanley")
as Distributor, the Fund makes available to institutional and high net worth
individual investors a series of portfolios which benefit from the investment
expertise and commitment to excellence associated with Morgan Stanley and its
affiliates.
 
    This Prospectus is designed to set forth concisely the information about the
Fund that a prospective investor should know before investing and it should be
retained for future reference. The Fund offers additional portfolios which are
described in other prospectuses and under "Prospectus Summary" below. The Fund
currently offers the following portfolios: (i) GLOBAL AND INTERNATIONAL EQUITY
- -- Active Country Allocation, Asian Equity, Asian Real Estate, Emerging Markets,
European Equity, European Real Estate, Global Equity, International Equity,
International Magnum, International Small Cap, Japanese Equity and Latin
American Portfolios; (ii) U.S. EQUITY -- Aggressive Equity, Emerging Growth,
Equity Growth, Small Cap Value Equity, Technology, U.S. Equity Plus, U.S. Real
Estate and Value Equity Portfolios; (iii) EQUITY AND FIXED INCOME -- Balanced
Portfolio; (iv) FIXED INCOME -- Emerging Markets Debt, Fixed Income, Global
Fixed Income, High Yield and Municipal Bond Portfolios; (v) MONEY MARKET --
Money Market and Municipal Money Market Portfolios. Additional information about
the Fund is contained in a "Statement of Additional Information," dated May 1,
1998, which is incorporated herein by reference. The Statement of Additional
Information and the prospectuses pertaining to the other portfolios of the Fund
are available upon request and without charge by writing or calling the Fund at
the address and telephone number set forth above.
 
  THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
   AND EXCHANGE COMMISSION, NOR HAS THE SECURITIES AND EXCHANGE COMMISSION
    PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS.     ANY
             REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
                  THE DATE OF THIS PROSPECTUS IS MAY 1, 1998.
<PAGE>
                                 FUND EXPENSES
 
    The following table illustrates all expenses and fees that a shareholder of
the U.S. Equity Plus Portfolio will incur:
<TABLE>
<CAPTION>
SHAREHOLDER TRANSACTION EXPENSES
- ----------------------------------------------------------------------------------------------
<S>                                                                                             <C>
Maximum Sales Load Imposed on Purchases
  Class A.....................................................................................       None
  Class B.....................................................................................       None
Maximum Sales Load Imposed on Reinvested Dividends
  Class A.....................................................................................       None
  Class B.....................................................................................       None
Deferred Sales Load
  Class A.....................................................................................       None
  Class B.....................................................................................       None
Redemption Fees
  Class A.....................................................................................       None
  Class B.....................................................................................       None
Exchange Fees
  Class A.....................................................................................       None
  Class B.....................................................................................       None
 
<CAPTION>
 
ANNUAL FUND OPERATING EXPENSES
 (AS A PERCENTAGE OF AVERAGE NET ASSETS)
- ----------------------------------------------------------------------------------------------
<S>                                                                                             <C>
Management Fee (Net of Fee Waiver)*
  Class A.....................................................................................      0.34%
  Class B.....................................................................................      0.34%
12b-1 Fees
  Class A.....................................................................................       None
  Class B.....................................................................................      0.25%
Other Expenses
  Class A.....................................................................................     0.46%+
  Class B.....................................................................................     0.46%+
                                                                                                ---------
Total Operating Expenses (Net of Fee Waivers or Expense Reimbursements)*
  Class A.....................................................................................      0.80%
  Class B.....................................................................................      1.05%
                                                                                                ---------
                                                                                                ---------
</TABLE>
 
- --------------
 
* The Adviser has agreed to waive its management fees and/or reimburse the
  Portfolio, if necessary, if such fees would cause the total annual operating
  expenses of the Portfolio to exceed a specified percentage of its average
  daily net assets. Absent the fee waiver, the management fee would be 0.45%.
  Absent the fee waivers and/or expense reimbursements, the Portfolio's total
  operating expenses are expected to be 0.91% of the average daily net assets of
  the Class A shares and 1.16% of the average daily net assets of the Class B
  shares. As a result of this reduction, the Management Fee stated above is
  lower than the contractual fee stated under "Management of the Fund." The
  Adviser reserves the right to terminate any of its fee waivers and/or expense
  reimbursements at any time in its sole discretion. For further information on
  Portfolio expenses, see "Management of the Fund."
+ Estimated.
 
                                       2
<PAGE>
    The purpose of the table above is to assist the investor in understanding
the various expenses that an investor in the Portfolio will bear directly or
indirectly. Expenses and fees for the Portfolio are based on estimates assuming
that the average daily net assets of both the Class A and Class B shares of the
Portfolio will be $50,000,000. Due to the continuous nature of Rule 12b-1 fees,
long-term Class B shareholders may pay more than the equivalent of the maximum
front-end sales charges otherwise permitted by the National Association of
Securities Dealers, Inc. ("NASD") Conduct Rules.
 
    The following example illustrates the expenses that you would pay on a
$1,000 investment assuming (i) a 5% annual rate of return, and (ii) redemption
at the end of each time period. As noted in the table above, the Portfolio
charges no redemption fees of any kind. The following example is based on the
total operating expenses of the Portfolio after fee waivers.
 
<TABLE>
<CAPTION>
                                                             1 YEAR       3 YEARS      5 YEARS     10 YEARS
                                                           -----------  -----------  -----------  -----------
<S>                                                        <C>          <C>          <C>          <C>
  Class A................................................   $       8    $      26        *            *
  Class B................................................   $      11    $      33        *            *
</TABLE>
 
- ------------------
* Because the Portfolio is new, the Fund has not projected expenses for the
  Portfolio beyond the three year period shown.
 
    THIS EXAMPLE SHOULD NOT BE CONSIDERED A REPRESENTATION OF PAST OR FUTURE
EXPENSES OR PERFORMANCE. THE PORTFOLIO IS NEW AND ACTUAL EXPENSES MAY BE GREATER
OR LESS THAN THOSE SHOWN.
 
                                       3
<PAGE>
                              FINANCIAL HIGHLIGHTS
 
    The following table provides financial highlights for the Class A and Class
B shares of the U.S. Equity Plus Portfolio for the period presented. The audited
financial highlights for the Portfolio's shares for the period presented are
part of the Fund's financial statements which appear in the Fund's December 31,
1997 Annual Report to Shareholders and which are incorporated by reference into
the Fund's Statement of Additional Information. The Portfolio's financial
highlights for the period presented have been audited by Price Waterhouse LLP,
whose unqualified report thereon is also included in the Annual Report. The
Annual Report and the financial statements therein, along with the Statement of
Additional Information, are available at no cost from the Fund at the address
and telephone number noted on the cover page of this Prospectus. The following
information should be read in conjunction with the financial statements and
notes thereto.
 
                                       4
<PAGE>
                           U.S. EQUITY PLUS PORTFOLIO
 
<TABLE>
<CAPTION>
                                                                     CLASS A                 CLASS B
                                                              ---------------------   ---------------------
                                                                   PERIOD FROM             PERIOD FROM
                                                                JULY 31, 1997* TO       JULY 31, 1997* TO
                                                               DECEMBER 31, 1997++     DECEMBER 31, 1997++
<S>                                                           <C>                     <C>
                                                              ---------------------------------------------
NET ASSET VALUE, BEGINNING OF PERIOD........................        $  10.00                $  10.00
                                                                     -------                 -------
INCOME FROM INVESTMENT OPERATIONS
  Net Investment Income (1).................................            0.06                    0.02
  Net Realized and Unrealized Gain on Investments...........            0.33                    0.37
                                                                     -------                 -------
    Total from Investment Operations........................            0.39                    0.39
                                                                     -------                 -------
                                                                     -------                 -------
DISTRIBUTIONS
  Net Investment Income.....................................           (0.05)                  (0.05)
  Net Realized Gain.........................................           (0.03)                  (0.03)
                                                                     -------                 -------
    Total Distributions.....................................           (0.08)                  (0.08)
                                                                     -------                 -------
NET ASSET VALUE, END OF PERIOD..............................        $  10.31                $  10.31
                                                                     -------                 -------
                                                                     -------                 -------
TOTAL RETURN................................................            3.94%                   3.93%
                                                                     -------                 -------
                                                                     -------                 -------
RATIOS AND SUPPLEMENTAL DATA:
Net Assets, End of Period (Thousands).......................        $ 20,914                $    102
Ratio of Expenses to Average Net Assets (1).................            0.80%**                 1.05%**
Ratio of Net Investment Income to Average Net Assets (1)....            1.32%**                 0.48%**
Portfolio Turnover Rate.....................................              15%                     15%
Average Commission Rate Per Share...........................        $ 0.0300                $ 0.0300
- ----------------
(1) Effect of voluntary expense limitation during the
 period:
      Per share benefit to net investment income............        $   0.07                $  0.00+
    Ratios before expense limitation:
      Expenses to Average Net Assets........................            2.37%**                 2.63%**
      Net Investment Loss to Average Net Assets.............           (0.25)%**               (0.32)%**
</TABLE>
 
- --------------------------------------------------------------------------------
 
 * Commencement of operations
** Annualized
 + Amount is less than $0.01 per share.
++ Per share amounts for the period ended December 31, 1997 are based on average
shares outstanding.
 
                                       5
<PAGE>
                               PROSPECTUS SUMMARY
THE FUND
 
    The Fund consists of thirty-two portfolios, offering institutional investors
and high net worth individual investors a broad range of investment choices
coupled with the advantages of a no-load mutual fund with Morgan Stanley and its
affiliates providing customized services as Adviser, Administrator and
Distributor. Each portfolio offers Class A shares and Class B shares, except for
the International Small Cap and Municipal Money Market Portfolios, which offer
only Class A shares. Each portfolio has its own investment objective and
policies designed to meet its specific goals. The investment objective of the
Portfolio described in this Prospectus is as follows:
    -The U.S. EQUITY PLUS PORTFOLIO seeks long term capital appreciation by
     investing primarily in equity securities of issuers included in the
     Standard & Poor's 500 Index ("S&P 500").
 
    The other portfolios of the Fund are described in other prospectuses which
may be obtained from the Fund at the address and phone number noted on the cover
of this Prospectus. The investment objectives of these other portfolios are
listed below.
 
    GLOBAL AND INTERNATIONAL EQUITY:
 
    -The ACTIVE COUNTRY ALLOCATION PORTFOLIO seeks long-term capital
     appreciation by investing in accordance with country weightings determined
     by the Adviser in equity securities of non-U.S. issuers which, in the
     aggregate, replicate broad country indices.
    -The ASIAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Asian issuers.
    -The ASIAN REAL ESTATE PORTFOLIO seeks to provide long-term capital
     appreciation by investing primarily in equity securities of companies in
     the Asian real estate industry.
    -The CHINA GROWTH PORTFOLIO seeks to provide long-term capital appreciation
     by investing primarily in equity securities of issuers in The People's
     Republic of China, Hong Kong and Taiwan.
    -The EMERGING MARKETS PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of emerging country issuers.
    -The EUROPEAN EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of European issuers.
    -The EUROPEAN REAL ESTATE PORTFOLIO seeks to provide current income and
     long-term capital appreciation by investing primarily in equity securities
     of companies in the European real estate industry.
    -The GLOBAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of issuers throughout the world,
     including U.S. issuers.
    -The GOLD PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of foreign and domestic issuers engaged in
     gold-related activities.
    -The INTERNATIONAL EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers.
    -The INTERNATIONAL MAGNUM PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of non-U.S. issuers domiciled in
     EAFE countries.
    -The INTERNATIONAL SMALL CAP PORTFOLIO seeks long-term capital appreciation
     by investing primarily in equity securities of non-U.S. issuers with equity
     market capitalizations of less than $1 billion.
 
                                       6
<PAGE>
    -The JAPANESE EQUITY PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Japanese issuers.
    -The LATIN AMERICAN PORTFOLIO seeks long-term capital appreciation by
     investing primarily in equity securities of Latin American issuers and,
     from time to time, debt securities issued or guaranteed by Latin American
     governments or governmental entities.
 
    U.S. EQUITY:
 
    -The AGGRESSIVE EQUITY PORTFOLIO seeks capital appreciation by investing
     primarily in corporate equity and equity-linked securities.
    -The EMERGING GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing primarily in growth-oriented equity securities of small- to
     medium-sized corporations.
    -The EQUITY GROWTH PORTFOLIO seeks long-term capital appreciation by
     investing in growth-oriented equity securities of medium and large
     capitalization companies.
    -The MICROCAP PORTFOLIO seeks long-term capital appreciation by investing
     primarily in growth-oriented equity securities of small corporations.
    -The SMALL CAP VALUE EQUITY PORTFOLIO seeks high long-term total return by
     investing in equity securities of small- to medium-sized companies which
     the Adviser believes to be undervalued.
    -The TECHNOLOGY PORTFOLIO seeks long-term capital appreciation by investing
     primarily in equity securities of companies that, in the opinion of the
     Adviser, are expected to benefit from their involvement in technology and
     technology-related industries.
    -The U.S. REAL ESTATE PORTFOLIO seeks to provide above-average current
     income and long-term capital appreciation by investing primarily in equity
     securities of companies in the U.S. real estate industry, including
     substantial investment in real estate investment trusts.
    -The VALUE EQUITY PORTFOLIO seeks high total return by investing in equity
     securities which the Adviser believes to be undervalued relative to the
     stock market in general at the time of purchase.
 
    EQUITY AND FIXED INCOME:
 
    -The BALANCED PORTFOLIO seeks high total return while preserving capital by
     investing in a combination of equity securities which the Adviser believes
     to be undervalued and fixed income securities.
 
    FIXED INCOME:
 
    -The EMERGING MARKETS DEBT PORTFOLIO seeks high total return by investing
     primarily in debt securities of government, government-related and
     corporate issuers located in emerging countries.
    -The FIXED INCOME PORTFOLIO seeks to produce a high total return consistent
     with the preservation of capital by investing in a diversified portfolio of
     fixed income securities.
    -The GLOBAL FIXED INCOME PORTFOLIO seeks to produce an attractive real rate
     of return while preserving capital by investing in fixed income securities
     of issuers throughout the world, including U.S. issuers.
    -The HIGH YIELD PORTFOLIO seeks to maximize total return by investing in a
     diversified portfolio of high yield fixed income securities that offer a
     yield above that generally available on debt securities in the four highest
     rating categories of the recognized rating services.
    -The MORTGAGE-BACKED SECURITIES PORTFOLIO seeks to produce as high a level
     of current income as is consistent with the preservation of capital by
     investing primarily in a variety of investment grade mortgage-backed
     securities.
 
                                       7
<PAGE>
    -The MUNICIPAL BOND PORTFOLIO seeks to produce a high level of current
     income consistent with preservation of principal by investing in municipal
     obligations, the interest on which is exempt from federal income tax.
 
    MONEY MARKET:
 
    -The MONEY MARKET PORTFOLIO seeks to maximize current income and preserve
     capital while maintaining high levels of liquidity through investing in
     high quality money market instruments with remaining maturities of one year
     or less.
    -The MUNICIPAL MONEY MARKET PORTFOLIO seeks to maximize current tax-exempt
     income and preserve capital while maintaining high levels of liquidity
     through investing in high quality money market instruments with remaining
     maturities of one year or less which are exempt from federal income tax.
 
   THE CHINA GROWTH, GOLD, MICROCAP AND MORTGAGE-BACKED SECURITIES PORTFOLIOS
   ARE CURRENTLY NOT BEING OFFERED.
 
INVESTMENT MANAGEMENT
 
    Morgan Stanley Asset Management Inc., a wholly owned subsidiary of Morgan
Stanley Dean Witter & Co., acts as investment adviser to the Fund and each of
its portfolios. As of March 31, 1998, Morgan Stanley Asset Management Inc. and
its affiliated institutional asset management companies managed assets of
approximately $166 billion, including assets under fiduciary advice. See
"Management of the Fund -- Investment Adviser" and "Management of the Fund --
Administrator."
 
HOW TO INVEST
 
    Class A shares of the Portfolio are offered directly to investors at net
asset value with no sales commission or 12b-1 charges. Class B shares of the
Portfolio are offered at net asset value with no sales commission, but with a
12b-1 fee, which is accrued daily and paid quarterly, equal to 0.25% of the
Class B shares' average daily net assets on an annualized basis. The minimum
initial investment, generally, is $500,000 for Class A shares of the Portfolio
and $100,000 for Class B shares of the Portfolio. The minimum initial investment
amount is reduced for certain categories of investors. For additional
information on how to purchase shares and minimum initial investments, see
"Purchase of Shares."
 
HOW TO REDEEM
 
    Class A shares or Class B shares of the Portfolio may be redeemed at any
time, without cost, at the net asset value per share of the applicable class
next determined after receipt of the redemption request. The redemption price
may be more or less than the purchase price. Certain redemptions that cause the
value of an account to remain for a continuous 60-day period below the minimum
investment amount for Class A shares or for Class B shares may result in
involuntary redemption or automatic conversion. For additional information on
how to redeem shares and involuntary redemption or conversion, see "Purchase of
Shares" and "Redemption of Shares."
 
                                       8
<PAGE>
RISK FACTORS
 
    Investing in the Portfolio entails certain risks and considerations of which
an investor should be aware. The Portfolio's share price and investment returns
fluctuate and, when redeemed, an investment in the Portfolio may be worth more
or less than its original cost. The investment policies of the Portfolio may
entail the following risk factors:
 
    -EQUITY SECURITIES. The Portfolio will invest in equity securities. Prices
     of equity securities fluctuate in response to many factors, including the
     financial health of the issuers and changes in economic and market
     conditions.
 
    -DERIVATIVES. The Portfolio may invest in instruments that derive their
     values from those of specified securities, indices, currencies or other
     points of reference. These derivatives, including those used to manage
     risk, are themselves subject to the risks of the different markets in which
     they are traded and, therefore, may or may not serve their intended
     purposes.
 
    For additional information about risk factors, see also "Investment
Objectives and Policies" and "Additional Investment Information."
 
                                       9
<PAGE>
                       INVESTMENT OBJECTIVE AND POLICIES
 
    The Portfolio's investment objective is to provide long-term capital
appreciation by investing primarily in equity securities of issuers included in
the S&P 500. The Portfolio's investment objective is a fundamental policy which
may not be changed without the approval of a majority of the Portfolio's
outstanding voting securities. There is no assurance that the Portfolio will
attain its objective. Other investment policies described below are not
fundamental policies unless otherwise noted and may be changed without
shareholder approval. In addition to the investments and strategies described
below, the Portfolio may invest in certain securities and obligations as set
forth in "Additional Investment Information" and as described under "Investment
Objectives and Policies" in the Statement of Additional Information.
 
    The Portfolio seeks a total return that exceeds the return of the S&P 500
with price volatility similar to that of the S&P 500. With respect to the
Portfolio, equity securities include common and preferred stocks, convertible
securities, and rights and warrants to purchase common stocks. Under normal
circumstances, the Portfolio will invest at least 65% of its assets in U.S.
equity securities (including American Depositary Receipts ("ADRs")) and at least
80% of its assets in equity securities. In addition, the Portfolio may enter
into securities index futures contracts that are traded on recognized securities
or futures exchanges. The Portfolio may enter into such futures contracts as an
efficient way to initiate an investment in a basket of securities and/or to gain
equity market exposure with small cash balances.
 
    The S&P 500 is a widely recognized, unmanaged index of U.S. equity market
activity. The performance of the S&P 500 is based upon the aggregate performance
of a selected portfolio of publicly traded common stocks which are market value
weighted (shares outstanding times stock price) so that each company's influence
on index performance is directly proportional to its market value. The S&P 500
includes monthly adjustments to reflect reinvestment of dividends and other
distributions thereby reflecting the total return of the securities comprising
the index. The S&P 500 is produced by Standard & Poor's, a division of The
McGraw-Hill Companies, Inc. ("S&P"). "Standard & Poor's", "S&P" and "S&P 500"
are trademarks of S&P and have been licensed for use by Morgan Stanley.
 
    The Adviser's approach in selecting among the issuers comprising the S&P 500
is both value and growth driven. By applying its proprietary portfolio
management process, the Adviser will seek to identify those securities which it
believes to be undervalued and/or to have superior growth potential. In
constructing the Portfolio's investment portfolio, the Adviser will apply a
systematic stock screening and selection process using current and historical
stock prices, earnings, cash flow, dividend yield information, consensus
earnings and earnings growth forecasts, and Morgan Stanley analyst
recommendations for the stocks represented in the S&P 500, as well as other
economic variables. In the selection process, the Adviser seeks to produce a
portfolio of stocks and portfolio weightings thereof which maximizes the
expected performance of the Portfolio relative to the S&P 500 while maintaining
a stable difference between the return of the Portfolio and the return of the
index.
 
                       ADDITIONAL INVESTMENT INFORMATION
 
    AMERICAN DEPOSITARY RECEIPTS.  The Portfolio may invest in ADRs. ADRs are
securities, typically issued by a U.S. financial institution (a "depositary"),
that evidence ownership interests in a security or a pool of securities issued
by a foreign issuer (the "underlying issuer") and deposited with the depositary.
ADRs include
 
                                       10
<PAGE>
American Depositary Shares and New York Shares and may be "sponsored" or
"unsponsored." Sponsored ADRs are established jointly by a depositary and the
underlying issuer, whereas unsponsored ADRs may be established by a depositary
without participation by the underlying issuer. The issuers of the stock of
unsponsored ADRs are not obligated to disclose material information in the
United States and therefore, there may not be a correlation between such
information and the market value of the ADR. Generally, ADRs in registered form
are designed for use in the U.S. securities market and ADRs in bearer form are
designed for use in securities markets outside the United States.
 
    CONVERTIBLE SECURITIES AND WARRANTS.  The Portfolio may invest in securities
such as convertible securities, preferred stock, warrants or other securities
exchangeable under certain circumstances for shares of common stock. Warrants
are instruments giving holders the right, but not the obligation, to buy shares
of a company at a given price during a specified period.
 
    LOANS OF PORTFOLIO SECURITIES.  The Portfolio may lend its securities to
brokers, dealers, domestic and foreign banks or other financial institutions for
the purpose of increasing net investment income. These loans must be secured
continuously by cash or equivalent collateral or by a letter of credit at least
equal to the market value of the securities loaned plus accrued interest or
income. There may be risks of delay in recovery of the securities or even loss
of rights in the collateral should the borrower of the securities fail
financially. The Portfolio will not enter into securities loan transactions
exceeding, in the aggregate, 33 1/3% of the market value of the Portfolio's
total assets.
 
    MONEY MARKET INSTRUMENTS.  The Portfolio is permitted to invest in money
market instruments, although the Portfolio intends to stay invested in
securities satisfying its primary investment objective to the extent practical.
Consistent with its investment policies, the Portfolio may make money market
investments pending other investment or settlement for liquidity. In addition,
the Portfolio may invest in money market instruments for temporary defensive
purposes during adverse market conditions. The money market investments
permitted for the Portfolio include: obligations of the U.S. Government and its
agencies and instrumentalities, obligations of foreign sovereignties, commercial
paper, bank obligations (including certificates of deposit), other debt
securities and repurchase agreements.
 
    REPURCHASE AGREEMENTS.  The Portfolio may enter into repurchase agreements
with brokers, dealers or banks that meet the credit guidelines established by
the Fund's Board of Directors. In a repurchase agreement, the Portfolio buys a
security from a seller that has agreed to repurchase it at a mutually agreed
upon date and price, reflecting the interest rate effective for the term of the
agreement. The term of these agreements is usually from overnight to one week
and never exceeds one year. A repurchase agreement may be viewed as a fully
collateralized loan of money by the Portfolio to the seller. The Portfolio
always receives securities with a market value at least equal to the purchase
price (including accrued interest) as collateral, and this value is maintained
during the term of the agreement. If the seller defaults and the collateral
value declines, the Portfolio might incur a loss. If bankruptcy proceedings are
commenced with respect to the seller, the Portfolio's realization upon the
collateral may be delayed or limited. The Portfolio may not enter into
repurchase agreements with more than seven days to maturity if, as a result,
more than 15% of the market value of the Portfolio's net assets are invested in
these agreements and other investments for which market quotations are not
readily available or which are otherwise illiquid.
 
                                       11
<PAGE>
    TEMPORARY INVESTMENTS.  During periods in which the Adviser believes changes
in economic, financial or political conditions make it advisable, each Portfolio
may, for temporary defensive purposes, invest up to 100% of its total assets in
certain short-term and medium-term debt obligations or hold cash. The short-term
and medium-term debt obligations in which a Portfolio may invest consist of (i)
obligations of the U.S. or foreign governments, their respective agencies or
instrumentalities; (ii) money market instruments; and (iii) instruments
denominated in any currency issued by international development agencies.
 
    WHEN-ISSUED AND DELAYED DELIVERY SECURITIES.  The Portfolio may purchase
securities on a when-issued or delayed delivery basis. In such transactions,
instruments are bought with payment and delivery taking place in the future in
order to secure what is considered to be an advantageous yield or price at the
time of the transaction. Delivery of and payment for these securities may take
as long as a month or more after the date of the purchase commitment but will
take place no more than 120 days after the trade date. The Portfolio will
maintain with the custodian a segregated account of cash or liquid securities in
an amount at least equal to these commitments. The payment obligation and the
interest rates that will be received are each fixed at the time the Portfolio
enters into the commitment and no interest accrues to the Portfolio until
settlement. Thus, it is possible that the market value at the time of settlement
could be higher or lower than the purchase price if, among other factors, the
general level of interest rates has changed. It is a current policy of the
Portfolio not to enter into when-issued commitments exceeding in the aggregate
15% of the market value of the Portfolio's total assets less liabilities, other
than the obligations created by these commitments.
 
DERIVATIVE PRODUCTS (DERIVATIVES)
 
    The Portfolio is permitted to utilize various exchange-traded and
over-the-counter derivative instruments and derivative securities, both for
hedging and non-hedging purposes. Permitted derivative products include, but are
not limited to: futures contracts ("futures"); forward contracts ("forwards");
options; swaps, caps, collars and floors; structured notes; and other derivative
products yet to be developed, so long as these new products are used in a manner
consistent with the objective of the Portfolio. These derivative products may be
based upon a wide variety of underlying rates, indices, instruments, securities
and other products, such as interest rates, foreign currencies, foreign and
domestic fixed income and equity securities, groups or "baskets" of securities
and securities indices (for each derivative product, the "underlying").
Exclusive of forward foreign currency contracts and any derivative products used
for hedging purposes, the Portfolio will limit its use of derivative products to
33 1/3% of its total assets, measured by the aggregate notional amount of
outstanding derivative products.
 
    The Portfolio may use derivative products under a number of different
circumstances to further its investment objective. For example, the Portfolio
may purchase derivatives to gain exposure to a market quickly in response to
changes in the Portfolio's investment strategy, upon the inflow of investable
cash or when the derivative provides greater liquidity than the underlying
market. The Portfolio may also use derivatives when it is restricted from
directly owning the "underlying" or when derivatives provide a pricing advantage
or lower transaction costs. The Portfolio also may purchase combinations of
derivatives in order to gain exposure to an investment in lieu of actually
purchasing such investment. Derivatives may also be used by the Portfolio for
hedging or risk management purposes and in other circumstances when the Adviser
believes it advantageous to do so consistent with the Portfolio's investment
objective and policies. The Portfolio will not use derivatives in a manner that
creates leverage, except to the extent that the use of leverage is expressly
permitted by the Portfolio's investment policies, and then only in a manner
consistent with such policies.
 
                                       12
<PAGE>
    The use of derivative products is a highly specialized activity which
involves investment techniques and risks different from those associated with
ordinary portfolio securities transactions. If the Adviser is incorrect in
forecasts of market values, interest rates, and currency exchange rates, the
investment performance of the Portfolio will be less favorable than it would
have been if these investment techniques had not been used.
 
    Some of the derivative products in which the Portfolio may invest and some
of the risks related thereto are describe in more detail below.
 
FUTURES CONTRACTS (FUTURES) AND FORWARD CONTRACTS (FORWARDS)
 
    The Portfolio may purchase and sell futures contracts, such as futures on
securities indices, baskets of securities, foreign currencies and interest rates
of the type generally known as financial futures. These are standardized
contracts that are bought and sold on organized exchanges. A futures contract
obligates a party to buy or sell a specific amount of the "underlying," such as
for example, a particular foreign currency, on a specified future date at a
specified price or to settle the value in cash.
 
    The Portfolio may also purchase and sell forward contracts, such as forward
rate agreements and other financial forward contracts. The Portfolio may also
use foreign currency forward contracts which are separately discussed elsewhere
in this Prospectus. See "Foreign Currency Forward Contracts" above. These
forward contracts are privately negotiated and are bought and sold in the
over-the-counter market. Like a future, a forward contract obligates a party to
buy or sell a specific amount of the underlying on a specified future date at a
specified price. The terms of the forward contract are customized. Forward
contracts, like other over-the-counter contracts that are negotiated directly
with an individual counterparty, subject the Portfolio to the risk of
counterparty default.
 
    In some cases, the Portfolio may be able to use either futures contracts,
forward contracts or exchange-traded or over-the-counter options to accomplish
similar purposes. In all cases, the Portfolio will use these products only as
permitted by applicable laws and regulations. Some of the ways in which the
Portfolio may utilize futures contracts, forward contracts and related options
are as follows:
 
    The Portfolio may sell securities index futures contracts and/or index
options thereon in anticipation of or during a market decline to attempt to
offset the decrease in market value of investments in its portfolio, or may
purchase securities index futures or options in order to gain market exposure.
There currently are limited securities index futures and options on such futures
in many countries, particularly emerging countries. The nature of the strategies
adopted by the Adviser, and the extent to which those strategies are used, may
depend on the development of such markets. The Portfolio may also purchase and
sell foreign currency futures to hedge its respective holdings and commitments
against changes in the level of future currency rates or to adjust its exposure
to a particular currency.
 
    The Portfolio may engage in transactions in interest rate futures and
related products. The value of these contracts rises and falls inversely with
changes in interest rates. The Portfolio may engage in such transactions to
hedge its holdings of debt instruments against future changes in interest rates
or for other purposes.
 
    The Portfolio may also purchase or sell futures and forwards on other
financial instruments, such as U.S. Government securities and certificates of
deposit. The value of these contracts also rises and falls inversely with
changes in interest rates. The Portfolio may engage in financial futures and
forward contracts for both hedging and non-hedging purposes.
 
                                       13
<PAGE>
    Gains and losses on futures contracts, forward contracts and related options
depend on the Adviser's ability to predict correctly the direction of securities
prices, interest rates and other economic factors. Other risks associated with
the use of these instruments include (i) imperfect correlation between the
change in market value of investments held by the Portfolio and the prices of
derivative products relating to investments purchased or sold by the Portfolio,
and (ii) possible lack of a liquid secondary market for a derivative product and
the resulting inability to close out a position. The risk that the Portfolio
will be unable to close out a position will be minimized by only entering into
transactions for which there appears to be a liquid exchange or secondary
market. In some strategies, the risk of loss in trading on futures and related
transactions can be substantial, due both to the low margin deposits required
and the extremely high degree of leverage involved in pricing.
 
    Under rules adopted by the Commodity Futures Trading Commission (the
"CFTC"), the Portfolio may, without registering with the CFTC as a Commodity
Pool Operator, enter into futures contracts and options thereon for both hedging
and non-hedging purposes, provided that not more than 5% of the Portfolio's
total assets at the time of entering the transaction are required as margin and
option premiums to secure obligations under such contracts relating to non-bona
fide hedging activities.
 
OPTION TRANSACTIONS
 
    The Portfolio may seek to increase its returns or may hedge its portfolio
investments through options transactions with respect to individual securities,
indices or baskets in which the Portfolio may invest; other financial
instruments; and foreign currency. Various options may be purchased and sold on
either the exchange-traded or over-the-counter markets.
 
    The Portfolio may purchase put and call options. Purchasing a put option
gives the Portfolio the right, but not the obligation, to sell the underlying
(such as a securities index or a particular foreign currency) at the exercise
price either on a specific date or during a specified exercise period.
Purchasing a call option gives the Portfolio a similar right, but not the
obligation, to purchase the underlying. The purchaser pays a premium to the
seller (also known as the writer) of the option.
 
    The Portfolio also may write put and call options on investments held in its
portfolio, as well as foreign currency options. The Portfolio that has written
an option receives a premium that increases the Portfolio's return on the
underlying in the event the option expires unexercised or is closed out at a
profit. However, by writing a call option, the Portfolio will limit its
opportunity to profit from an increase in the market value of the underlying
above the exercise price of the option. By writing a put option, the Portfolio
will be exposed to the amount by which the price of the underlying is less than
the strike price.
 
    By writing an option, the Portfolio incurs an obligation either to buy (in
the case of a put option) or sell (in the case of a call option) the underlying
from the purchaser of the option at the option's exercise price, upon exercise
by the purchaser. Pursuant to guidelines established by the Board of Directors,
the Portfolio may only write options that are "covered." A covered call option
means that until the expiration of the option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will continue to own (i) the underlying; (ii) securities or instruments
convertible or exchangeable without the payment of any consideration into the
underlying; or (iii) a call option on the same underlying with a strike price no
higher than the price at which the underlying was sold pursuant to a short
option position. In the case of a put option, the Portfolio will either earmark
or segregate sufficient liquid assets to cover its obligations under the option
or will own another put option on the same underlying with an equal or higher
strike price.
 
                                       14
<PAGE>
    There currently are limited options markets in many countries, particularly
emerging market countries, and the nature of the strategies adopted by the
Adviser and the extent to which those strategies are used will depend on the
development of these options markets. The primary risks associated with the
Portfolio's use of options as described include (i) imperfect correlation
between the change in market value of investments held, purchased or sold by the
Portfolio and the prices of options relating to such investments, and (ii)
possible lack of a liquid secondary market for an option.
 
INTEREST RATE, CURRENCY, COMMODITY AND EQUITY SWAPS, CAPS, COLLARS AND FLOORS
 
    Swaps are privately negotiated over-the-counter derivative products in which
two parties agree to exchange payment streams calculated in relation to a rate,
index, instrument or certain securities and a particular "notional amount." As
with many of the other derivative products available to the Portfolio, the
underlying may include an interest rate (fixed or floating), a currency exchange
rate, a commodity price index, and a security, securities index or a combination
thereof. A great deal of flexibility is possible in the way the products may be
structured, with the effect being that the parties may have exchanged amounts
equal to the return on one rate, index or group of securities for another. For
example, in a simple fixed-to-floating interest rate swap, one party makes
payments equivalent to a fixed interest rate, and the other makes payments
equivalent to a specified interest rate index. The Portfolio may engage in
simple or more complex swap transactions involving a wide variety of
underlyings. The currency swaps that the Portfolio may enter will generally
involve an agreement to pay interest streams in one currency based on a
specified index in exchange for receiving interest streams denominated in
another currency. Such swaps may involve initial and final exchanges that
correspond to the agreed upon notional amount.
 
    Caps, collars and floors are privately-negotiated option-based derivative
products. The Portfolio may use one or more of these products in addition to or
in lieu of a swap involving a similar rate or index. As in the case of a put or
call option, the buyer of a cap or floor pays a premium to the writer. In
exchange for that premium, the buyer receives the right to a payment equal to
the differential if the specified index or rate rises above (in the case of a
cap) or falls below (in the case of a floor) a pre-determined strike level. As
in the case of swaps, obligations under caps and floors are calculated based
upon an agreed notional amount, and like most swaps (other than foreign currency
swaps), the entire notional amount is not exchanged and thus is not at risk. A
collar is a combination product in which the same party, such as the Portfolio,
buys a cap from and sells a floor to the other party. As with put and call
options, the amount at risk is limited for the buyer, but, if the cap or floor
is not hedged or covered, may be unlimited for the seller. Under current market
practice, caps, collars and floors between the same two parties are generally
documented under the same "master agreement." In some cases, options and forward
agreements may also be governed by the same master agreement. In the event of a
default, amounts owed under all transactions entered into under, or covered by,
the same master agreement would be netted and only a single payment would be
made.
 
    Swaps, caps, collars and floors are credit-intensive products. When the
Portfolio enters into a swap transaction it bears the risk of default, i.e.
nonpayment, by the other party. The guidelines under which the Portfolio enters
derivative transactions, along with some features of the transactions
themselves, are intended to reduce these risks to the extent reasonably
practicable, although they cannot eliminate the risks entirely. Under guidelines
established by the Board of Directors, the Portfolio may enter into swaps only
with parties that meet certain credit rating guidelines. Consistent with current
market practices, the Portfolio will generally enter into swap transactions on a
net basis, and all swap transactions with the same party will be documented
under a single master agreement to provide for net payment upon default. In
addition, the Portfolio's obligations under
 
                                       15
<PAGE>
an agreement will be accrued daily (offset against any amounts owing to the
Portfolio) and any accrued, but unpaid, net amounts owed to the other party to a
master agreement will be covered by the maintenance of a segregated account
consisting of cash or liquid securities.
 
    Interest rate and total rate of return (fixed income or equity) swaps
generally do not involve the delivery of securities, other underlying assets, or
principal. In such case, if the other party to an interest rate or total rate of
return swap defaults, the Portfolio's risk of loss will consist of the payments
that the Portfolio is contractually entitled to receive from the other party.
This may not be true for currency swaps that require the delivery of the entire
notional amount of one designated currency in exchange for the other. If there
is a default by the other party, the Portfolio may have contractual remedies
pursuant to the agreements related to the transaction.
 
STRUCTURED NOTES
 
    Structured notes are derivative securities for which the amount of principal
repayment and/or interest payments is based upon the movement of one or more
factors. These factors include, but are not limited to, currency exchange rates,
interest rates (such as the prime lending rate and LIBOR) and stock indices,
such as the S&P 500. In some cases, the impact of the movements of these factors
may increase or decrease through the use of multipliers or deflators. The
Portfolio may use structured notes to tailor its investments to the specific
risks and returns the Adviser wishes to accept while avoiding or reducing
certain other risks.
 
                             INVESTMENT LIMITATIONS
 
    The Portfolio is a diversified investment company and is therefore subject
to the following fundamental limitations: as to 75% of its total assets, the
Portfolio may not (i) invest more than 5% of its total assets in the securities
of any one issuer, except obligations of the U.S. Government, its agencies, and
instrumentalities, or (ii) own more than 10% of the outstanding voting
securities of any one issuer.
 
    The Portfolio also operates under certain investment restrictions that are
deemed fundamental investment limitations and may be changed only with the
approval of the holders of a majority of the Portfolio's outstanding shares and
under certain non-fundamental investment limitations that may be changed without
shareholder approval. See "Investment Limitations" in the Statement of
Additional Information."
 
                             MANAGEMENT OF THE FUND
 
    INVESTMENT ADVISER.  Morgan Stanley Asset Management Inc. is the Adviser and
Administrator of the Fund and each Portfolio. The Adviser provides investment
advice and portfolio management services, pursuant to an Investment Advisory
Agreement and, subject to the supervision of the Fund's Board of Directors,
makes each of the Portfolio's day-to-day investment decisions, arranges for the
execution of portfolio transactions and generally manages each of the
Portfolio's investments. The Adviser is entitled to receive from the Portfolio
an annual management fee, payable quarterly, equal to 0.45% of the average daily
net assets of the Portfolio. The Adviser has voluntarily agreed to a reduction
in the fees payable to it and/or to reimburse the Portfolio, if necessary, if
such fees would cause total annual operating expenses of the Portfolio to exceed
0.80% of the average daily net assets of the Class A shares of the Portfolio and
1.05% of the average daily net assets of the Class B shares of the Portfolio.
 
                                       16
<PAGE>
    The Adviser, with principal offices at 1221 Avenue of the Americas, New
York, New York 10020, conducts a worldwide portfolio management business and
provides a broad range of portfolio management services to customers in the
United States and abroad. Morgan Stanley Dean Witter & Co. ("MSDW") is the
direct parent of the Adviser and Morgan Stanley. MSDW is a preeminent global
financial services firm that maintains leading market positions in each of its
three primary businesses -- securities, asset management and credit services. At
March 31, 1998, the Adviser, together with its affiliated institutional asset
management companies, managed assets of approximately $166 billion, including
assets under fiduciary advice. See "Management of the Fund" in the Statement of
Additional Information.
 
    PORTFOLIO MANAGERS.  NARAYAN RAMACHANDRAN AND EUGENE FLOOD JR. Narayan
Ramachandran joined the Adviser in 1996. He is a Principal of the Adviser and
Morgan Stanley and leads the quantitative equity strategies effort of the
Structured Asset Management business at the Adviser. He was previously Managing
Director at RogersCasey Associates, Inc. ("RogersCasey"), an investment
consulting and special assets advisory firm based in Darien, Connecticut. As
President of RogersCasey's investment advisory subsidiary, he was responsible
for leading the special assets advisory business with $2 billion in assets under
management. Prior to that, he was Director of Research for RogersCasey, with his
research efforts focused on quantitative investment models. He has a B.S. in
Chemical Engineering from the Indian Institute of Technology in Bombay and an
M.B.A. from the University of Michigan at Ann Arbor. Eugene Flood joined Morgan
Stanley in 1987. He is a Senior Equity Portfolio Manager of Structured Asset
Management and a Principal of the Adviser and Morgan Stanley. He has traded a
broad spectrum of instruments including equities, fixed income, foreign exchange
and commodities. Additionally, he has consulted for a variety of private sector
companies and government agencies. Prior to joining Morgan Stanley, Dr. Flood
was on the faculty of Stanford University's Graduate School of Business, where
he taught Finance. Dr. Flood received an A.B. in Economics from Harvard
University and a Ph.D. in Economics from the Massachusetts Institute of
Technology.
 
    ADMINISTRATOR.  The Adviser also provides administrative services to the
Fund pursuant to an Administration Agreement. The services provided under the
Administration Agreement are subject to the supervision of the officers and the
Board of Directors of the Fund and include day-to-day administration of matters
related to the corporate existence of the Fund, maintenance of its records,
preparation of reports, supervision of the Fund's arrangements with its
custodian and assistance in the preparation of the Fund's registration
statements under federal laws. The Administration Agreement also provides that
the Administrator, through its agents, will provide dividend disbursing and
transfer agent services to the Fund. For its services under the Administration
Agreement, the Fund pays the Adviser a monthly fee which on an annual basis
equals 0.15% of the average daily net assets of the Portfolio.
 
    Under an agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase provides certain administrative services to the Fund through
its corporate affiliate, Chase Global Funds Services Company ("CGFSC"). The
Adviser supervises and monitors such administrative services provided by CGFSC.
Their services are also subject to the supervision of the Board of Directors of
the Fund. CGFSC's business address is 73 Tremont Street, Boston, Massachusetts
02108-3913.
 
    DIRECTORS AND OFFICERS.  Pursuant to the Fund's Articles of Incorporation,
the Board of Directors decides upon matters of general policy and reviews the
actions of the Fund's Adviser, Administrator, Distributor and other service
providers. The officers of the Fund conduct and supervise its daily business
operations.
 
                                       17
<PAGE>
    DISTRIBUTOR.  Morgan Stanley serves as the exclusive Distributor of the
shares of the Fund. Under its Distribution Agreement with the Fund, Morgan
Stanley sells shares of the Portfolio upon the terms and at the current offering
price described in this Prospectus. Morgan Stanley is not obligated to sell any
certain number of shares of any Portfolio.
 
    The Portfolio currently offers only the classes of shares offered by this
Prospectus. The Portfolio may in the future offer one or more classes of shares
with features, distribution expenses or other expenses that are different from
those of the classes currently offered.
 
    The Fund has adopted a Plan of Distribution with respect to the Class B
shares pursuant to Rule 12b-1 under the 1940 Act (the "Plan"). Under the Plan,
the Distributor is entitled to receive from the Portfolio a distribution fee,
which is accrued daily and paid quarterly, of 0.25% of the Class B shares'
average daily net assets on an annualized basis. Each Plan is designed to
compensate the Distributor for its services in connection with distribution
assistance. The Distributor may retain any portion of the fee that it does not
expend in meeting its obligations to the Fund. The Distributor may compensate
financial intermediaries, plan fiduciaries and administrators for providing
distribution-related services, including account maintenance services, to
shareholders (including, where applicable, underlying beneficial owners) of
Class B shares.
 
    EXPENSES.  The Portfolio is responsible for payment of certain other fees
and expenses (including legal fees, accountants' fees, custodial fees and
printing and mailing costs) as specified in its agreements with the Adviser and
Morgan Stanley.
 
    YEAR 2000.  The management and distribution services provided to the Fund by
the Adviser and Morgan Stanley depend on the smooth functioning of their
computer systems. Many computer software systems in use today cannot recognize
the year 2000, but revert to 1900 or some other date, due to the manner in which
dates were encoded and calculated. That failure could have a negative impact on
the handling of securities trades, pricing and account services. The Adviser and
Morgan Stanley have been actively working on necessary changes to their own
computer systems to deal with the year 2000 problem and expect that their
systems will be adapted before that date. There can be no assurance, however,
that they will be successful. In addition, other unaffiliated service providers
may be faced with similar problems. The Adviser and Morgan Stanley are
monitoring their remedial efforts, however, there can be no assurance that they
and the services they provide will not be adversely affected.
 
    In addition, it is possible that the markets for securities in which the
Portfolio invests may be detrimentally affected by computer failures throughout
the financial services industry beginning January 1, 2000. Improperly
functioning trading systems may result in settlement problems and liquidity
issues. In addition, corporate and governmental data processing errors may
result in production problems for individual companies and overall economic
uncertainties. Earnings of individual issuers will be affected by remediation
costs, which may be substantial and may be reported inconsistently in U.S. and
foreign financial statements. Accordingly, the Portfolio's investments may be
adversely affected.
 
                                       18
<PAGE>
                               PURCHASE OF SHARES
 
    Class A shares and Class B shares of the Portfolio may be purchased at the
net asset value per share next determined after receipt by the Fund of a
purchase order as described under "Methods of Purchase." The net asset value per
share of the Portfolio is calculated on days that the New York Stock Exchange
("NYSE") and Chase (the "Custodian Bank") are open for business as of the close
of trading of the NYSE, normally 4:00 p.m. Eastern Time (the "Pricing Time").
 
MINIMUM INVESTMENT
 
    The minimum initial investment is $500,000 for Class A shares and $100,000
for Class B shares of the Portfolio. These minimums may be waived at the
discretion of the Adviser for certain types of investors, including trust
departments, brokers, dealers, agents, financial planners, financial services
firms, investment advisers or various retirement and deferred compensation plans
("Financial Intermediaries"), certain accounts managed by the Adviser and its
affiliates ("Managed Accounts"), and certain employees and customers of Morgan
Stanley and its affiliates. The Fund's determination of an investor's
eligibility to purchase shares of a given class will take precedence over the
investor's selection of a class.
 
METHODS OF PURCHASE
 
    Shares may be purchased directly from the Fund by Federal Funds wire, by
bank wire or by check. Investors may also invest in the Portfolio by purchasing
shares through Financial Intermediaries that have made arrangements with Morgan
Stanley. Some Financial Intermediaries may charge an additional service or
transaction fee. If a purchase is canceled due to nonpayment or because your
check does not clear, you will be responsible for any loss the Fund or its
agents incur. If you are already a shareholder, the Fund may redeem shares from
your account(s) to reimburse the Fund or its agents for any loss. In addition,
you may be prohibited or restricted from making future investments in the Fund.
 
    FEDERAL FUNDS WIRE.  Purchases may be made by having your bank wire Federal
Funds to the Fund's bank account. Federal Funds purchase orders will be accepted
only on a day on which the Fund and the Custodian Bank are open for business.
Your bank may charge a service fee for wiring Federal Funds. In order to ensure
proper handling of your purchase by Federal Funds wire, please follow these
steps:
 
    1. Place your order by telephoning the Fund at 1-800-548-7786. A Fund
       representative will request certain purchase information and provide you
       with a confirmation number.
 
    2. Instruct your bank to wire the specified amount to the Fund's Wire
       Concentration Bank Account as follows:
 
       The Chase Manhattan Bank
       One Manhattan Plaza
       New York, NY 10081-1000
       ABA# 021000021
       DDA# 910-2-733293
       Attn: Morgan Stanley Institutional Fund, Inc.
       Ref: (Portfolio name, your account number, your account name)
 
Please call the Fund at 1-800-548-7786 prior to wiring the funds.
 
    3. Complete and sign the Account Registration Form and mail it to the
       address shown thereon.
 
                                       19
<PAGE>
    When a purchase order is received prior to the Pricing Time and Federal
Funds are received prior to the close of the Federal Funds Wire Control Center
("FFWCC") (normally 6:00 p.m. Eastern Time), the purchase will be executed at
the net asset value computed on the date of receipt. Purchases for which an
order is received after the Pricing Time or for which Federal Funds are received
after the close of the FFWCC, will be executed at the net asset value next
determined. Certain institutional investors and financial institutions have
entered into an arrangement with Morgan Stanley, pursuant to which they may
place orders prior to the Pricing Time, but make payment in Federal Funds for
those shares on the following business day.
 
    BANK WIRE.  A purchase of shares by bank wire must follow the same procedure
as for a Federal Funds wire, described above. However, depending on the time the
bank wire is sent and which bank is handling the wire, money transferred by bank
wire may or may not be converted into Federal Funds prior to the close of the
FFWCC. Prior to conversion to Federal Funds and receipt by the Fund, an
investor's money will not be invested.
 
    CHECK.  An account may be opened by completing and signing an Account
Registration Form and mailing it, together with a check payable to "Morgan
Stanley Institutional Fund, Inc. -- [portfolio name]" to:
 
    Morgan Stanley Institutional Fund, Inc.
    P.O. Box 2798
    Boston, Massachusetts 02208-2798
 
    The Fund ordinarily is credited with Federal Funds within one business day
of deposit of a check. Thus, a purchase of shares by check ordinarily will be
credited to your account at the net asset value per share determined on the next
business day after receipt. An investor's money will not be invested prior to
crediting of Federal Funds.
 
    INVESTMENT THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to receive purchase and
redemption orders from underlying beneficial owners, such as retirement plan
participants, generally on each business day. Each business evening, the
Financial Intermediary aggregates all orders received from underlying beneficial
owners prior to the Pricing Time on that business day and places a net purchase
and/or redemption order(s) by the morning of the next business day. These orders
normally are executed at the net asset value that was computed for the Portfolio
as of the close of the previous business day.
 
    ADDITIONAL INVESTMENTS.  You may purchase additional shares for your account
at any time by purchasing shares at net asset value by any of the methods
described above. The minimum additional investment generally is $1,000 for the
Portfolio. The minimum additional investment may be lower for certain accounts,
described above under "Minimum Investment." For purchases directly from the
Fund, your account name, the Portfolio name and the class selected must be
specified in the letter or wire to assure proper crediting to your account.
 
INVOLUNTARY CONVERSION AND REDEMPTION OF NEW ACCOUNT SHARES
 
    Class A and Class B shares of the Portfolio may be subject to the
involuntary conversion and redemption features described below. The conversion
and redemption features may be waived at the discretion of the Adviser for
shares held in a Managed Account and shares purchased through a Financial
Intermediary. Accounts that were open prior to January 2, 1996 are not subject
to involuntary conversion or redemption. The Fund reserves the right to modify
or terminate the conversion or redemption features of the shares at any time
upon 60 days notice to shareholders.
 
                                       20
<PAGE>
    CONVERSION FROM CLASS A TO CLASS B SHARES.  If the value of an account
containing Class A shares falls below $500,000 (but remains at or above
$100,000) because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $500,000 (but remains at or
above $100,000) for a continuous 60-day period, the Class A shares in such
account will convert to Class B shares and will be subject to the distribution
fee and other features applicable to Class B shares. The Fund will not convert
Class A shares to Class B shares based solely upon changes in the market that
reduce the net asset value of shares. Under current tax law, conversion between
share classes is not a taxable event to the shareholder.
 
    CONVERSION FROM CLASS B TO CLASS A SHARES.  If the value of an account
containing Class B shares increases to $500,000 or more, whether due to
shareholder purchases or market activity, the Class B shares will convert to
Class A shares. Class B shares purchased through a Financial Intermediary that
has entered into an arrangement with the Fund for the purchase of such shares
may not be converted. Under current tax law, such conversion is not a taxable
event to the shareholder. Class A shares converted from Class B shares are
subject to the same minimum account size requirements as are applicable to New
Accounts containing Class A shares described above.
 
    INVOLUNTARY REDEMPTION OF SHARES.  If the value of an account falls below
$100,000 because of shareholder redemption(s), the Fund will notify the
shareholder, and if the account value remains below $100,000 for a continuous
60-day period, the shares in such account will be subject to redemption by the
Fund. The Fund will not redeem shares based solely upon changes in the market
that reduce the net asset value of shares. If redeemed, redemption proceeds will
be promptly paid to the shareholder.
 
                              REDEMPTION OF SHARES
 
    Class A and Class B shares of the Portfolio may be redeemed at any time and
without charge at the net asset value per share next determined after receipt by
the Fund of a redemption order as described under "Methods of Redemption."
Redemption proceeds may be more or less than the purchase price of your shares
depending on, among other factors, the market value of the investment securities
held by the Portfolio.
 
METHODS OF REDEMPTION
 
    Shares may be redeemed directly from the Fund by mail or by telephone.
However, shares purchased through a Financial Intermediary must be redeemed
through a Financial Intermediary. Certain Financial Intermediaries may charge an
additional service or transaction fee.
 
    BY MAIL.  The Portfolio will redeem shares upon receipt of a redemption
request in "good order." Redemption requests may be sent by regular mail to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798 or, by overnight courier, to Morgan Stanley Institutional Fund, Inc.,
c/o Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913.
 
    "Good order" means that the request to redeem shares must include the
following:
 
    1. A letter of instruction or a stock assignment specifying the class and
       number of shares or dollar amount to be redeemed, signed by all
       registered owners of the shares in the exact names in which they are
       registered;
 
    2. Any required signature guarantees; and
 
                                       21
<PAGE>
    3. Other supporting legal documents, if required, in the case of estates,
       trusts, guardianships, custodianships, corporations, pension and
       profit-sharing plans and other organizations.
 
    Redemption requests received in "good order" prior to the Pricing Time will
be executed at the net asset value computed on the date of receipt. Redemption
requests received after the Pricing Time will be executed at the next determined
net asset value. Shareholders who are uncertain of requirements for redemption
by mail should consult with a Fund representative.
 
    BY TELEPHONE.  If you have previously elected the Telephone Redemption
Option on the Account Registration Form, you can redeem Portfolio shares by
calling the Fund and requesting that the redemption proceeds be mailed to you or
wired to your bank. Please contact one of the Fund's representatives for further
details. To change the commercial bank or account designated to receive
redemption proceeds, send a written request to the Fund at the address above.
Requests to change the bank or account must be signed by each shareholder and
each signature must be guaranteed. The telephone redemption option may be
difficult to implement at times, particularly during volatile market conditions.
If you experience difficulty in making a telephone redemption, you may redeem
shares by mail as described above.
 
    The Fund and the Transfer Agent will employ reasonable procedures to confirm
that instructions communicated by telephone are genuine. An investor may be
required to provide personal identification information at the time an account
is opened and prior to effecting each telephone transaction. In addition, all
telephone transaction requests will be recorded and investors may be required to
provide additional telecopied written instructions regarding transaction
requests. Neither the Fund nor the Transfer Agent will be responsible for any
loss, liability, cost or expense for following instructions received by
telephone that either of them reasonably believes to be genuine.
 
    REDEMPTION THROUGH FINANCIAL INTERMEDIARIES.  Certain Financial
Intermediaries have made arrangements with the Fund to accept redemption
requests from underlying beneficial owners. These redemptions may be processed
in the same way as purchases made through such Financial Intermediaries, as
described above.
 
FURTHER REDEMPTION INFORMATION
 
    The Fund normally makes payment for all shares redeemed within one business
day of receipt of the request, and in no event more than seven days after
receipt of a redemption request in good order. However, payments to investors
redeeming shares which were purchased by check will not be made until payment
for the purchase has been collected, which may take up to eight days after the
date of purchase. The Fund may suspend the right of redemption or postpone the
date upon which redemptions are effected at times when the NYSE is closed, or
under any emergency conditions as determined by the Securities and Exchange
Commission (the "Commission").
 
    If the Board of Directors determines that it would be detrimental to the
best interests of the remaining shareholders of the Portfolio to make payment in
cash, the Fund may pay redemption proceeds in whole or in part by a
distribution-in-kind of readily marketable portfolio securities in accordance
with applicable rules of the Commission. Shareholders may incur brokerage
charges on the sale of portfolio securities received in payment of redemptions.
 
                                       22
<PAGE>
    To protect your account, the Fund and its agents from fraud, signature
guarantees are required to verify the identity of the person who has authorized
certain redemptions. Please contact the Fund or see the Statement of Additional
Information for further information.
 
                         ACCOUNT POLICIES AND SERVICES
 
EXCHANGE FEATURES
 
    You may exchange shares of the Portfolio that you own for shares of any
other available portfolio(s) of the Fund, subject to certain limitations. You
cannot exchange for shares of the International Equity, Emerging Markets, Small
Cap Value Equity, Balanced or Gold Portfolios because they are currently closed
to new investors. In addition, certain portfolios may be unavailable to
shareholders who purchased portfolio shares through a Financial Intermediary.
Contact your Financial Intermediary to determine which portfolios are available
for exchange.
 
    Before you make an exchange, you should read the prospectus of the
portfolio(s) in which you seek to invest. The class of shares you receive in the
exchange will be determined in the same manner as any other purchase of shares,
including minimum initial investment and account size requirements, and will not
be based on the class of shares you surrender for the exchange. Exchange
transactions are treated as a redemption followed by a purchase. Therefore, an
exchange will be considered a taxable event for shareholders subject to tax.
Exchange transactions will be processed at the net asset value per share next
determined after receipt of the request. Shares of the portfolios may be
exchanged by mail or telephone. The telephone exchange privilege is automatic
and made available without shareholder election. The exchange privilege may be
modified or terminated by the Fund at any time upon 60-days notice to
shareholders.
 
    BY MAIL.  To exchange shares by mail, send a written exchange request to
Morgan Stanley Institutional Fund, Inc., P.O. Box 2798, Boston, Massachusetts
02208-2798. Your written exchange request should include (i) the name, class of
shares and account number of your current Portfolio; (ii) the name(s) and
class(es) of shares of the portfolio(s) into which you intend to exchange
shares; and (iii) the signatures of all registered account holders.
 
    BY TELEPHONE.  To exchange shares by telephone, call the Fund at the phone
number provided on the cover of this Prospectus. A Fund representative will
request (i) the name, class of shares and account number of your current
Portfolio, and (ii) the name(s) and class(es) of shares of the portfolio(s) into
which you intend to exchange shares. For additional information regarding
responsibility for the authenticity of telephoned instructions, see "Redemption
of Shares" above.
 
TRANSFER OF REGISTRATION
 
    You may transfer the registration of any of your Portfolio shares to another
person by sending a written request to Morgan Stanley Institutional Fund, Inc.,
P.O. Box 2798, Boston, Massachusetts 02208-2798. It may not be possible to
transfer the registration of certain shares purchased through a Financial
Intermediary. As with redemptions, the written request must be received in "good
order" before any transfer can be made. Transferring the registration of shares
may affect the eligibility of your account for a given class of shares and may
result in involuntary conversion or redemption of your shares.
 
                                       23
<PAGE>
OTHER ACCOUNT INFORMATION
 
    The Fund does not issue share certificates for the Portfolio. All shares
purchased are confirmed to you and credited to your account on the Fund's books
maintained by the Adviser or its agents. You will have the same rights and
ownership with respect to such shares as if certificates had been issued.
 
EXCESSIVE TRADING
 
    Frequent trades in your account(s) can disrupt management of the Portfolio
and raise its expenses. Consequently, the Fund may, in its discretion and in the
interest of the Portfolio's shareholders and performance, bar a shareholder who
trades excessively from making further share purchases for an indefinite period.
The Fund considers excessive trading to be more than one purchase and sale
involving shares of the same class of a portfolio of the Fund within any 120-day
period. For example, the following series of transactions would amount to
excessive trading: exchanging shares of Portfolio A for shares of Portfolio B,
then exchanging shares of Portfolio B for shares of Portfolio C and then
exchanging shares of Portfolio C for shares of Portfolio A within a 120-day
period. Two types of transactions are exempt from these excessive trading
restrictions: (i) trades exclusively between money market portfolios, and (ii)
trades made in connection with an asset allocation service managed or advised by
the Adviser and/or any of its affiliates.
 
INVESTMENT IN PORTFOLIOS BY OTHER INVESTMENT ACCOUNTS
 
    Morgan Stanley or its affiliates, including Morgan Stanley Asset Management
Inc., manage investment accounts for other clients, including other investment
companies, that invest in Class A or Class B shares of the portfolios. From time
to time, one or more of the portfolios used for investment by these accounts may
experience relatively large investments or redemptions due to investment
decisions made on behalf of these accounts. These transactions will affect the
portfolios, since portfolios that experience significant redemptions may have to
sell portfolio securities and portfolios that receive additional cash will have
to invest it in additional portfolio securities. It is impossible to predict the
overall impact of these transactions over time, however, there could be adverse
effects on portfolio management. These transactions also could have tax
consequences if sales of portfolio securities result in gains or could increase
transaction costs. The Adviser, representing the interests of the portfolios, is
committed to minimizing the impact of these transactions to the portfolios. The
Adviser, however, will have a conflict in fulfilling this responsibility in that
it also advises these investment accounts. The Adviser will monitor the impact
of these transactions on the portfolio.
 
                              VALUATION OF SHARES
 
    The net asset value per share of a class of shares of the Portfolio is
determined by dividing the total market value of the Portfolio's investments and
other assets attributable to such class, less any liabilities attributable to
such class, by the total number of outstanding shares of such class of the
Portfolio. Net asset value is calculated separately for each class of the
Portfolio. Net asset value per share is determined as of the close of the NYSE
(normally 4:00 p.m. Eastern Time) on each day that the NYSE is open for
business. Price information on listed securities is taken from the exchange
where the security is primarily traded. Securities listed on a U.S. securities
exchange for which market quotations are available are valued at the last quoted
sale price on the day the valuation is made. Unlisted securities and listed
securities not traded on the valuation date and for which market quotations are
not readily available are valued at a price within a range not exceeding the
current asked price nor less than the current bid price. The current bid and
asked prices are determined based on the average of the bid and asked prices
quoted on such valuation date by reputable brokers.
 
                                       24
<PAGE>
    Bonds and other fixed income securities are valued according to the broadest
and most representative market, which will ordinarily be the over-the-counter
market. Net asset value includes interest on fixed income securities, which is
accrued daily. In addition, bonds and other fixed income securities may be
valued on the basis of prices provided by a pricing service when such prices are
believed to reflect the fair market value of such securities. The prices
provided by a pricing service are determined without regard to bid or last sale
prices, but take into account institutional-size trading in similar groups of
securities and any developments related to the specific securities. Securities
not priced in this manner are valued at the most recently quoted bid price or,
when securities exchange valuations are used, at the latest quoted sale price on
the day of valuation. If there is no such reported sale, the latest quoted bid
price will be used. Securities purchased with remaining maturities of 60 days or
less are valued at amortized cost, if it approximates market value. In the event
that amortized cost does not approximate market value, market prices as
determined above will be used.
 
    The value of other assets and securities for which quotations are not
readily available (including restricted securities) and those securities for
which it is inappropriate to determine prices in accordance with the above-
stated procedure are determined in good faith at fair value using methods
determined by the Board of Directors. For purposes of calculating net asset
value per share, all assets and liabilities initially expressed in foreign
currencies will be translated into U.S. dollars at the mean of the bid and asked
price of such currencies against the U.S. dollar last quoted by any major bank.
 
    Although the legal rights of Class A and Class B shares will be identical,
the different expenses borne by each class will result in different net asset
values and dividends for the class. Dividends will differ by approximately the
amount of the distribution expense differential among the classes. The net asset
value of Class B shares will generally be lower than the net asset value of the
Class A shares as a result of the distribution expense charged to Class B
shares.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time advertise total return for each class of the
Portfolio. THESE FIGURES ARE BASED ON HISTORICAL EARNINGS AND ARE NOT INTENDED
TO INDICATE FUTURE PERFORMANCE.
 
    The Portfolio may advertise"total return" which shows what an investment in
a class of the Portfolio would have earned over a specified period of time (such
as one, five or ten years), assuming that all distributions and dividends by the
Portfolio were reinvested in the same class on the reinvestment dates during the
period. Total return does not take into account any federal or state income
taxes that may be payable on dividends and distributions or on redemption. The
Fund may also include comparative performance information in advertising or
marketing the Portfolio's shares, including data from Lipper Analytical
Services, Inc., other industry publications, business periodicals, rating
services and market indices.
 
    The performance figures for Class B shares will generally be lower than
those for Class A shares because of the distribution fee charged to Class B
shares.
 
                                       25
<PAGE>
                   DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    All income dividends and capital gains distributions for a class of shares
will be automatically reinvested in additional shares at net asset value, except
when, upon written notice to the Fund or by checking off the appropriate box in
the Distribution Option Section on the Account Registration Form, a shareholder
elects to receive income dividends and capital gains distributions in cash.
 
    The Portfolio expects to distribute substantially all of its taxable net
investment income in the form of annual dividends. Net realized capital gains,
if any, after reduction for any available tax loss carryforwards will also be
distributed annually.
 
    Undistributed net investment income is included in the Portfolio's net
assets for the purpose of calculating net asset value per share. Therefore, on
the "ex-dividend" date, the net asset value per share excludes the dividend
(i.e., is reduced by the per share amount of the dividend). Dividends paid
shortly after the purchase of shares by an investor, although in effect a return
of capital, are taxable to shareholders subject to income tax.
 
    Because of the distribution fee and any other expenses that may be
attributable to the Class B shares, the net income attributable to and the
dividends payable on Class B shares will be lower than the net income
attributable to and the dividends payable on Class A shares. As a result, the
net asset value per share of the classes of the Portfolio will differ at times.
Expenses of the Portfolio allocated to a particular class of shares will be
borne on a pro rata basis by each outstanding share of that class.
 
                                     TAXES
 
    The following summary of certain federal income tax consequences is based on
current tax laws and regulations, which may be changed by legislative, judicial,
or administrative action.
 
    No attempt has been made to present a detailed explanation of the federal,
state, or local income tax treatment of the Portfolio or its shareholders.
Accordingly, shareholders are urged to consult their tax advisers regarding
specific questions as to federal, state and local income taxes.
 
    The Portfolio is treated as a separate entity for federal income tax
purposes and is not combined with the Fund's other portfolios. The Portfolio
intends to qualify for the special tax treatment afforded regulated investment
companies under Subchapter M of the Internal Revenue Code of 1986, as amended
(the "Code"), so that the Portfolio will be relieved of federal income tax on
that part of its net investment income and net capital gain that is distributed
to shareholders.
 
    The Portfolio intends to distribute substantially all of its taxable net
investment income (including, for this purpose, the excess of net short-term
capital gain over net long-term capital loss) to shareholders. Dividends from
the Portfolio's net investment income are taxable to shareholders as ordinary
income, whether received in cash or in additional shares. Such dividends paid by
the Portfolio will generally qualify for the dividends-received deduction for
corporate shareholders to the extent of qualifying dividend income received by
the Portfolio from U.S. corporations. The Portfolio will report annually to its
shareholders the amount of dividend income qualifying for such treatment.
 
    Distributions of net capital gains are taxable to shareholders as a 20% rate
gain distribution (taxed at a rate of 20%) or a 28% rate gain distribution
(taxed at a rate of 28%), depending upon the designation by the Portfolio
 
                                       26
<PAGE>
(such designation being dependent upon the holding period of the Portfolio in
the underlying asset generating the net capital gain), regardless of how long
the shareholder has held the Portfolio's shares. The Portfolio will send reports
annually to shareholders of the federal income tax status of all distributions
made during the preceding year.
 
    The Portfolio intends to make sufficient distributions or deemed
distributions of its ordinary income and capital gain net income (the excess of
short-term and long-term capital gain over short-term and long-term capital
loss, including any available capital loss carryforwards), prior to the end of
each calendar year to avoid liability for federal excise tax.
 
    Dividends and other distributions declared by the Portfolio in October,
November or December of any year and payable to shareholders of record on a date
in such month will be deemed to have been paid by the Portfolio and received by
the shareholders in that year if the distributions are paid by the Portfolio at
any time during the following January.
 
    The Fund may be required to withhold and remit to the U.S. Treasury 31% of
any dividends, capital gains distributions and redemption proceeds paid to any
individual or certain other non-corporate shareholder (i) who has failed to
provide a correct taxpayer identification number (generally an individual's
social security number or non-individual's employer identification number) on
the Account Registration Form; (ii) who is subject to backup withholding by the
Internal Revenue Service; or (iii) who has not certified to the Fund that such
shareholder is not subject to backup withholding. This backup withholding is not
an additional tax, and any amounts withheld may be credited against the
shareholder's ultimate U.S. tax liability.
 
    The sale, redemption or exchange of shares will result in taxable gain or
loss to the selling, redeeming or exchanging shareholder, depending upon whether
the fair market value of the sale, redemption or exchange proceeds exceed or is
less than the shareholder's adjusted tax basis in the sold, redeemed or
exchanged shares. If capital gains distributions have been made with respect to
shares that are sold at a loss after being held for six months or less, then the
loss is treated as a long-term capital loss to the extent of the capital gains
distributions.
 
    Conversions of shares between classes are not taxable events to the
shareholder.
 
    Shareholders are urged to consult with their tax advisers concerning the
application of state and local income taxes to investments in the Portfolio,
which may differ from the federal income tax consequences described above.
 
    THE TAX DISCUSSION SET FORTH ABOVE IS INCLUDED FOR GENERAL INFORMATION ONLY.
PROSPECTIVE INVESTORS SHOULD CONSULT THEIR OWN TAX ADVISERS WITH RESPECT TO THE
TAX CONSEQUENCES TO THEM OF AN INVESTMENT IN THE PORTFOLIO.
 
                             PORTFOLIO TRANSACTIONS
 
    The Adviser selects the brokers or dealers that will execute the purchases
and sales of investment securities for each of the Fund's portfolios. The
Adviser seeks the best execution of all portfolio transactions. A portfolio may
pay higher commission rates than the lowest available when the Adviser believes
it is reasonable to do so in light of the value of the research, statistical,
and pricing services provided by the broker effecting the transaction.
 
                                       27
<PAGE>
    It is not the Fund's practice to allocate brokerage or principal business on
the basis of sales of shares which may be made through intermediary brokers or
dealers. However, the Adviser may, consistent with NASD rules, place portfolio
orders with qualified broker-dealers who recommend the applicable portfolio to
their clients or who act as agents in the purchase of shares of the portfolio
for their clients.
 
    Subject to the overriding objective of obtaining the best execution of
orders, the Fund may use broker-dealer affiliates of the Adviser, including
Morgan Stanley, to effect portfolio brokerage transactions under procedures
adopted by the Fund's Board of Directors. For such transactions, the commission
rates and other remuneration paid to Morgan Stanley or other affiliates must be
fair and reasonable in comparison to those of other broker-dealers for
comparable transactions involving similar securities being purchased or sold
during a comparable time period.
 
PORTFOLIO TURNOVER
 
    The Portfolio generally does not invest for short-term trading purposes,
however, when circumstances warrant, the Portfolio may sell investment
securities without regard to the length of time they have been held. Market
conditions in a given year could result in a higher or lower portfolio turnover
rate than expected and the Portfolio will not consider portfolio turnover rate a
limiting factor in making investment decisions consistent with its objective and
policies. Higher portfolio turnover (e.g., over 100%) necessarily will cause the
Portfolio to pay correspondingly increased brokerage and trading costs. In
addition to transaction costs, higher portfolio turnover may result in the
realization of capital gains. As discussed under "Taxes," to the extent net
short-term capital gains are realized, any distributions resulting from such
gains are considered ordinary income for federal income tax purposes.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF COMMON STOCK
 
    The Fund was organized as a Maryland corporation on June 16, 1988. The
Articles of Incorporation, as amended and restated, permit the Fund to issue up
to 40 billion shares of common stock, with $.001 par value per share. Pursuant
to the Fund's Articles of Incorporation, the Board of Directors may increase the
number of shares the Fund is authorized to issue without the approval of the
shareholders of the Fund. The Board of Directors has the power to designate one
or more classes of shares of common stock and to classify and reclassify any
unissued shares with respect to such classes. The shares of common stock of each
portfolio are currently classified into two classes, the Class A shares and the
Class B shares, except for the International Small Cap, Money Market and
Municipal Money Market Portfolios, which offer only Class A shares.
 
    The shares of the Portfolio, when issued, will be fully paid, nonassessable,
fully transferable and redeemable at the option of the holder. The shares have
no preference as to conversion, exchange, dividends, retirement or other
features and have no pre-emptive rights. The shares of the Portfolio have
non-cumulative voting rights, which means that the holders of more than 50% of
the shares voting for the election of Directors can elect 100% of the Directors
if they choose to do so. Persons or organizations owning 25% or more of the
outstanding shares of the Portfolio may be presumed to "control" (as that term
is defined in the 1940 Act) the Portfolio. Under Maryland law, the Fund is not
required to hold an annual meeting of its shareholders unless required to do so
under the 1940 Act.
 
                                       28
<PAGE>
REPORTS TO SHAREHOLDERS
 
    The Fund will send to its shareholders annual and semi-annual reports. The
financial statements appearing in annual reports are audited by independent
accountants. Monthly unaudited portfolio data is also available from the Fund
upon request.
 
    In addition, the Adviser or its agent, as Transfer Agent, will send to each
shareholder having an account directly with the Fund a monthly statement showing
transactions in the account, the total number of shares owned, and any dividends
or distributions paid.
 
CUSTODIAN
 
    Chase is the Fund's Custodian for domestic and certain foreign assets. Chase
is not an affiliate of the Adviser or the Distributor. Morgan Stanley Trust
Company, Brooklyn, New York ("MSTC"), an affiliate of the Adviser and the
Distributor, acts as the Fund's custodian for assets held outside the United
States and employs subcustodians approved by the Board of Directors of the Fund
in accordance with regulations of the Commission for the purpose of providing
custodial services for such assets. MSTC may also hold certain domestic assets
for the Fund. For more information on the custodians, see "General Information
- -- Custody Arrangements" in the Statement of Additional Information.
 
DIVIDEND DISBURSING AND TRANSFER AGENT
 
    Chase Global Funds Services Company, 73 Tremont Street, Boston,
Massachusetts 02108-3913, acts as Dividend Disbursing and Transfer Agent for the
Fund.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits its annual financial statements.
 
FUND COUNSEL
 
    Morgan, Lewis & Bockius LLP acts as the Fund's legal counsel.
 
LITIGATION
 
    The Fund is not involved in any litigation.
 
                                       29
<PAGE>
   MORGAN STANLEY INSTITUTIONAL FUND, INC.
          U.S. EQUITY PLUS PORTFOLIO
           P.O. BOX 2798, BOSTON, MA 02208-2798
 
                           ACCOUNT REGISTRATION FORM
 
<TABLE>
<C>   <S>                                  <C>
                                           If you need assistance in filling out this form for the
      ACCOUNT INFORMATION                  Morgan Stanley Institutional Fund, Inc., please contact your
      Fill in where applicable             Morgan Stanley representative or call us toll free
                                           1-800-548-7786. Please print all items except signature, and
                                           mail to the Fund at the address above.
  A)  REGISTRATION
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF SURVIVORSHIP PRESUMED
      UNLESS
         TENANCY IN COMMON
         IS INDICATED)
</TABLE>
 
1.
  First Name  Initial  Last Name
 
2.
  First Name  Initial  Last Name
 
  First Name  Initial  Last Name
 
<TABLE>
<C>   <S>                                  <C>
      3. CORPORATIONS,
         TRUSTS AND OTHERS
         Please call the Fund for
         additional documents that may be
         required to set up account and
         to authorize transactions.
</TABLE>
 
3.
 
<TABLE>
<S>                     <C>                 <C>                   <C>               <C>
Type of Registration:   / / INCORPORATED    / / UNINCORPORATED    / / PARTNERSHIP   / / UNIFORM GIFT/TRANSFER TO MINOR
                                            ASSOCIATION                               (ONLY ONE CUSTODIAN AND MINOR PERMITTED)
</TABLE>
 
/ / TRUST ________________________  / / OTHER (Specify) ________________________
 
<TABLE>
<C>   <S>                        <C>
  B)  MAILING ADDRESS
      Please fill in
      completely, including
      telephone number(s).
</TABLE>
 
/ / United States Citizen  / / Resident Alien
                   Street or P.O. Box
                   City
                   State                   Zip
Home Telephone No.                   Business Telephone No.
 
/ / Non-Resident Alien
 
Permanent Address (Where you reside permanently for tax purposes)
                   Street Address
                   City
                   Country                   Postal Code
Home Telephone No.                    Business Telephone No.
 
Current Mailing Address (If different from Permanent Address)
                   Street Address
                   City
                   Country
Postal Code
Home Telephone No.                   Business Telephone No.
 
<TABLE>
<C>   <S>                        <C>                                                 <C>
  C)  TAXPAYER                   Enter your Taxpayer Identification Number. For most individual taxpayers, this is your Social
      IDENTIFICATION             Security Number.
      NUMBER
      1. INDIVIDUAL
      2. JOINT TENANTS
         (RIGHTS OF
      SURVIVORSHIP PRESUMED
      UNLESS
         TENANCY IN COMMON
         IS INDICATED)
      For Custodian account      1.  TAXPAYER IDENTIFICATION NUMBER ("TIN")          OR         SOCIAL SECURITY NUMBER ("SSN")
      of a minor (Uniform
      Gifts/Transfers to Minor
      Acts), give the Social
      Security Number of
      the minor.
                                 2.    TIN                                           OR    SSN
                                       TIN                                           OR    SSN
                                                         IMPORTANT TAX INFORMATION
                                 You (as a payee) are required by law to provide us (as payer) with your correct TIN(s) or SSN(s).
                                 Accounts that have a missing or incorrect TIN(s) or SSN(s) will be subject to backup withholding
                                 at a 31% rate on dividends, distributions and other payments. If you have not provided us with
                                 your correct TIN(s) or SSN(s), you may be subject to a $50 penalty imposed by the Internal
                                 Revenue Service.
                                 Backup withholding is not an additional tax; the tax liability of persons subject to backup
                                 withholding will be reduced by the amount of tax withheld. If withholding results in an
                                 overpayment of taxes, a refund may be obtained.
                                 You may be notified that you are subject to backup withholding under Section 3406(a)(1)(C) of the
                                 Internal Revenue Code because you have underreported interest or dividends or you were required
                                 to, but failed to, file a return which would have included a reportable interest or dividend
                                 payment.
</TABLE>
 
<PAGE>
 
<TABLE>
<C>   <S>                        <C>                             <C>
  D)  PORTFOLIO AND              For Purchase of the following
      CLASS SECTION              Portfolio(s):                   / / Class A Shares
      (Class A shares minimum    U.S. Equity Plus Portfolio      $ / / Class B Shares $
      $500,000 and Class B                                       Total Initial Investment
      shares minimum $100,000).                                  $
      Please indicate class and
      amount.
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  E)  METHOD OF
      INVESTMENT
      Please indicate portfolio
      and manner of payment.
</TABLE>
 
Payment by:
 
/ / Check (MAKE CHECK PAYABLE TO MORGAN STANLEY INSTITUTIONAL FUND,
INC.--PORTFOLIO NAME)
 
<TABLE>
<S>                                                                                 <C>
/ / Exchange $                           From
                                                      Name of Portfolio                               Account No.
/ / Account previously established by:  / / Phone exchange  / / Wire on
                                                                                       Account No.                         (Check
                                                                                      (Previously assigned by the Fund)     Digit)
                                                                            Date
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  F)  DISTRIBUTION               Income dividends and capital gains distributions (if any) to
      OPTION                     be reinvested in additional shares unless either box below
                                 is checked.
                                 / / Income dividends to be paid in cash, capital gains
                                 distributions (if any) in shares.
                                 / / Income dividends and capital gains distributions (if
                                 any) to be paid in cash.
</TABLE>
 
<TABLE>
<C>   <S>                             <C>                                       <C>
  G)  TELEPHONE                       / / I/we hereby authorize the Fund and
      REDEMPTION                      its agents to honor any telephone         Name of COMMERCIAL Bank (Not Savings
      AND EXCHANGE                    requests to wire redemption proceeds to   Bank)
      OPTION                          the commercial bank indicated at right    Bank Account No.
      Please select at time of        and/or mail redemption proceeds to the
      initial application if you      name and address in which my/our fund     Bank ABA No.
      wish to redeem or exchange      account is registered if such requests
      shares by telephone. A          are believed to be authentic.             Name(s) in which your Bank Account is
      SIGNATURE GUARANTEE IS          The Fund and the Fund's Transfer Agent    Established
      REQUIRED IF BANK ACCOUNT IS     will employ reasonable procedures to
      NOT REGISTERED IDENTICALLY TO   confirm that instructions communicated    Bank's Street
      YOUR FUND ACCOUNT.              by telephone are genuine. These           Address
      TELEPHONE REQUESTS FOR          procedures include requiring the
      REDEMPTIONS OR EXCHANGE WILL    investor to provide certain personal      City        State Zip
      NOT BE HONORED UNLESS THE BOX   identification information at the time
      IS CHECKED.                     an account is opened and prior to
                                      effecting each transaction requested by
                                      telephone. In addition, all telephone
                                      transaction requests will be recorded
                                      and investors may be required to provide
                                      additional telecopied written
                                      instructions of transaction requests.
                                      Neither the Fund nor the Transfer Agent
                                      will be responsible for any loss,
                                      liability, cost or expense for following
                                      instructions received by telephone that
                                      it reasonably believes to be genuine.
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  H)  INTERESTED PARTY
      OPTION                     Name
      In addition to the
      account statement sent to
      my/our registered          Address
      address, I/we hereby
      authorize the Fund to      City         State         Zip Code
      mail duplicate statements
      to the name and address
      provided at right.
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  I)  DEALER
      INFORMATION
                                 Representative Name       Representative No.       Branch No.
</TABLE>
 
<TABLE>
<C>   <S>                        <C>
  J)  SIGNATURE OF
      ALL HOLDERS
      AND TAXPAYER
      CERTIFICATION
      Sign Here
</TABLE>
 
<TABLE>
<S>                                                 <C>
The undersigned certify that I/we have full authority and legal capacity to purchase and redeem shares
of the Fund and affirm that I/we have received a current Prospectus of the Morgan Stanley
Institutional Fund, Inc. and agree to be bound by its terms.
  BY SIGNING THIS APPLICATION, I/WE HEREBY CERTIFY UNDER PENALTIES OF PERJURY THAT THE INFORMATION ON
THIS APPLICATION IS COMPLETE AND CORRECT AND THAT AS REQUIRED BY FEDERAL LAW (PLEASE CHECK APPLICABLE
BOXES BELOW):
/ / U.S. CITIZEN(S)/TAXPAYER(S):
       / / I/WE CERTIFY THAT (1) THE NUMBER(S) SHOWN ABOVE ON THIS FORM IS/ARE THE CORRECT SSN(S) OR
           TIN(S) AND (2) I/WE ARE NOT SUBJECT TO ANY BACKUP WITHHOLDING EITHER BECAUSE (A) I/WE ARE
           EXEMPT FROM BACKUP WITHHOLDING; (B) I/WE HAVE NOT BEEN NOTIFIED BY THE INTERNAL REVENUE
           SERVICE ("IRS") THAT I/WE ARE SUBJECT TO BACKUP WITHHOLDING AS A RESULT OF A FAILURE TO
           REPORT ALL INTEREST OR DIVIDENDS; OR (C) THE IRS HAS NOTIFIED ME/US THAT I AM/WE ARE NO
           LONGER SUBJECT TO BACKUP WITHHOLDING.
       / / IF NO TIN(S) OR SSN(S) HAS/HAVE BEEN PROVIDED ABOVE, I/WE HAVE APPLIED, OR INTEND TO APPLY,
           TO THE IRS OR THE SOCIAL SECURITY ADMINISTRATION FOR A TIN OR A SSN AND I/WE UNDERSTAND
           THAT IF I/WE DO NOT PROVIDE EITHER NUMBER TO CHASE GLOBAL FUNDS SERVICES COMPANY ("CGFSC")
           WITHIN 60 DAYS OF THE DATE OF THIS APPLICATION OR IF I/WE FAIL TO FURNISH MY/OUR CORRECT
           SSN(S) OR TIN(S), I/WE MAY BE SUBJECT TO A PENALTY AND A 31% BACKUP WITHHOLDING ON
           DISTRIBUTIONS AND REDEMPTION PROCEEDS. (PLEASE PROVIDE EITHER NUMBER ON IRS FORM W-9). YOU
           MAY REQUEST SUCH FORM BY CALLING CGFSC AT 800-282-4404.
 
/ / NON-U.S. CITIZEN(S)/TAXPAYER(S)
  UNDER PENALTIES OF PERJURY, I/WE CERTIFY THAT I/WE ARE NOT U.S. CITIZENS OR RESIDENTS AND I/WE ARE
EXEMPT FOREIGN PERSONS AS DEFINED BY THE INTERNAL REVENUE SERVICE.
 
THE INTERNAL REVENUE SERVICE DOES NOT REQUIRE YOUR CONSENT TO ANY PROVISION OF THIS DOCUMENT OTHER
THAN THE CERTIFICATIONS REQUIRED TO AVOID BACKUP WITHHOLDING.
 
(X)                                                 (X)
Signature         Date                              Signature (if joint account, both must sign)  Date
</TABLE>
<PAGE>
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
 
  NO DEALER, SALES REPRESENTATIVE OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS, OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS, IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND, IF
GIVEN OR MADE, SUCH OTHER INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON
AS HAVING BEEN AUTHORIZED BY THE FUND OR THE DISTRIBUTOR. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER BY THE FUND OR THE DISTRIBUTOR TO SELL OR A SOLICITATION
OF AN OFFER TO BUY ANY OF THE SECURITIES OFFERED HEREBY IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION IN SUCH
JURISDICTION.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<S>                                                 <C>
                                                    PAGE
                                                    ----
Fund Expenses.....................................    2
Financial Highlights..............................    4
Prospectus Summary................................    6
Investment Objective and Policies.................   10
Additional Investment Information.................   10
Investment Limitations............................   16
Management of the Fund............................   16
Purchase of Shares................................   19
Redemption of Shares..............................   21
Account Policies and Services.....................   23
Valuation of Shares...............................   24
Performance Information...........................   25
Dividends and Capital Gains Distributions.........   26
Taxes.............................................   26
Portfolio Transactions............................   27
General Information...............................   28
Account Registration Form
</TABLE>
 
                           U.S. EQUITY PLUS PORTFOLIO
 
                               A PORTFOLIO OF THE
                                 MORGAN STANLEY
                            INSTITUTIONAL FUND, INC.
 
                                  Common Stock
                               ($.001 PAR VALUE)
 
                                 -------------
                                   PROSPECTUS
                                 -------------
 
                               Investment Adviser
                                 Morgan Stanley
                             Asset Management Inc.
 
                                  Distributor
                              Morgan Stanley & Co.
                                  INCORPORATED
 
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
 
                      P.O. BOX 2798, BOSTON, MA 02208-2798
 
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
- -------------------------------------------
<PAGE>
                    MORGAN STANLEY INSTITUTIONAL FUND, INC.
                      STATEMENT OF ADDITIONAL INFORMATION
 
    Morgan Stanley Institutional Fund, Inc. (the "Fund") is a no-load, open-end
management investment company with diversified and non-diversified series
("Portfolios"). The Fund currently consists of thirty-two Portfolios offering a
broad range of investment choices. The Fund is designed to provide clients with
attractive alternatives for meeting their investment needs. Each Portfolio,
except the Municipal Money Market, International Small Cap and China Growth
Portfolios, offers two classes of shares, the Class A shares and the Class B
shares (each, a "Multiclass Portfolio"). The Class A shares and the Class B
shares currently offered by each Multiclass Portfolio have different minimum
investment requirements and fund expenses. Shares of each Portfolio are offered
with no sales charge or exchange or redemption fee (except that the
International Small Cap Portfolio may impose a 1.00% transaction fee). This
Statement of Additional Information ("SAI") addresses information applicable to
all of the Fund's Portfolios.
 
    The Fund is designed to meet the investment needs of discerning investors
who place a premium on quality and personal service. With Morgan Stanley Asset
Management Inc. as Adviser ("MSAM" or the "Adviser"), and with Morgan Stanley &
Co. Incorporated ("Morgan Stanley") as Distributor, the Fund makes available to
institutional and high net worth individual investors a series of portfolios
which benefit from the investment expertise and commitment to excellence
associated with Morgan Stanley and its affiliates.
 
    This SAI is not a prospectus but should be read in conjunction with the
several prospectuses of the Fund's Portfolios (the "Prospectuses"). To obtain
any of the Prospectuses, please call the Morgan Stanley Institutional Fund, Inc.
Services Group at 1-800-548-7786.
                                 --------------
 
                               TABLE OF CONTENTS
 
<TABLE>
<S>                                     <C>
                                        PAGE
                                        ----
INVESTMENT OBJECTIVES AND POLICIES......   2
TAXES...................................  17
GENERAL REGULATED INVESTMENT COMPANY
  QUALIFICATIONS........................  17
GENERAL TAX TREATMENT OF QUALIFYING RICs
  AND SHAREHOLDERS......................  18
SPECIAL TAX CONSIDERATIONS RELATING TO
  MUNICIPAL BOND AND MUNICIPAL MONEY
  MARKET PORTFOLIOS.....................  19
SPECIAL TAX CONSIDERATIONS RELATING TO
  FOREIGN INVESTMENTS...................  20
TAXES AND FOREIGN SHAREHOLDERS..........  20
PURCHASE OF SHARES......................  21
REDEMPTION OF SHARES....................  21
SHAREHOLDER SERVICES....................  21
INVESTMENT LIMITATIONS..................  22
DETERMINING MATURITIES OF CERTAIN
  INSTRUMENTS...........................  24
MANAGEMENT OF THE FUND..................  24
NET ASSET VALUE FOR MONEY MARKET
  PORTFOLIOS............................  33
PERFORMANCE INFORMATION.................  33
GENERAL INFORMATION.....................  41
DESCRIPTION OF RATINGS..................  42
FINANCIAL STATEMENTS....................  43
</TABLE>
 
STATEMENT OF ADDITIONAL INFORMATION DATED MAY 1, 1998
 
    Prospectus for the European Real Estate Portfolio, Asian Real Estate
    Portfolio and U.S. Real Estate Portfolio, dated May 1, 1998
 
    Prospectus for the Asian Equity Portfolio and Japanese Equity Portfolio,
    dated May 1, 1998
 
    Prospectus for the Emerging Markets Portfolio, Emerging Markets Debt
    Portfolio and Latin American Portfolio, dated May 1, 1998
 
    Prospectus for the Global Equity Portfolio, International Equity Portfolio,
    International Small Cap Portfolio and European Equity Portfolio, dated May
    1, 1998
 
    Prospectus for the U.S. Equity Plus Portfolio, dated May 1, 1998
 
    Prospectus for the International Magnum Portfolio, dated May 1, 1998
 
    Prospectus for the Fixed Income Portfolio, Municipal Bond Portfolio,
    Mortgage-Backed Securities Portfolio, Money Market Portfolio and Municipal
    Money Market Portfolio, dated May 1, 1998
 
    Prospectus for the Equity Growth Portfolio, Emerging Growth Portfolio and
    Aggressive Equity Portfolio, dated May 1, 1998
 
    Prospectus for the Small Cap Value Equity Portfolio, Value Equity Portfolio,
    Balanced Portfolio, Global Fixed Income Portfolio and High Yield Portfolio,
    dated May 1, 1998
 
    Prospectus for the Active Country Allocation Portfolio, dated May 1, 1998
 
    Prospectus for the Technology Portfolio, dated May 1, 1998
 
    Prospectus for the Gold Portfolio, dated May 1, 1998
 
    Prospectus for the China Growth Portfolio, dated May 1, 1998
 
    Prospectus for the MicroCap Portfolio dated May 1, 1998
 
                                                                           1
<PAGE>
                       INVESTMENT OBJECTIVES AND POLICIES
 
    The following policies supplement the investment objectives and policies set
forth in the Fund's Prospectuses. For additional discussion of the investment
policies and techniques of a particular Portfolio, see the Prospectus relating
to that Portfolio.
 
BRADY BONDS
 
    Certain Portfolios may invest in debt obligations customarily referred to as
"Brady Bonds," which are created through the exchange of existing commercial
bank loans to foreign entities for new obligations in connection with debt
restructuring under a plan introduced by former U.S. Secretary of the Treasury
Nicholas F. Brady (the "Brady Plan"). They may be collateralized or
uncollateralized and issued in various currencies (although most are U.S.
dollar-denominated) and they are actively traded in the over-the-counter
secondary market. The Portfolios may purchase Brady Bonds either in the primary
or secondary markets. The price and yield of Brady Bonds purchased in the
secondary market will reflect the market conditions at the time of purchase,
regardless of the stated face amount and the stated interest rate. With respect
to Brady Bonds with no or limited collateralization, a Portfolio will rely for
payment of interest and principal primarily on the willingness and ability of
the issuing government to make payment in accordance with the terms of the
bonds.
 
    U.S. dollar-denominated, collateralized Brady Bonds, which may be fixed rate
par bonds or floating rate discount bonds, are generally collateralized in full
as to principal due at maturity by U.S. Treasury zero coupon obligations which
have the same maturity as the Brady Bonds. Interest payments on these Brady
Bonds generally are collateralized by cash or securities in an amount that, in
the case of fixed rate bonds, is equal to at least one year of rolling interest
payments or, in the case of floating rate bonds, initially is equal to at least
one year's rolling interest payments based on the applicable interest rate at
that time and is adjusted at regular intervals thereafter. Certain Brady Bonds
are entitled to "value recovery payments" in certain circumstances, which in
effect constitute supplemental interest payments but generally are not
collateralized. Brady Bonds are often viewed as having three or four valuation
components: (i) the collateralized repayment of principal at final maturity;
(ii) the collateralized interest payments; (iii) the uncollateralized interest
payments; and (iv) any uncollateralized repayment of principal at maturity
(these uncollateralized amounts constitute the "residual risk"). In the event of
a default with respect to collateralized Brady Bonds that results in
acceleration of the payment obligations of the issuer, the U.S. Treasury zero
coupon obligations held as collateral for the payment of principal will not be
distributed to investors, nor will such obligations be sold and the proceeds
distributed. The collateral will be held to the scheduled maturity of the
defaulted Brady Bonds by the collateral agent, at which time the face amount of
the collateral will equal the principal payments which would have then been due
on the Brady Bonds in the normal course. In addition, in light of the residual
risk of the Brady Bonds and, among other factors, the history of defaults with
respect to commercial bank loans by public and private entities of countries
issuing Brady Bonds, investments in Brady Bonds should be viewed as speculative.
 
EMERGING COUNTRY EQUITY AND DEBT SECURITIES
 
    The definition of emerging country equity or debt securities includes
securities of companies that may have characteristics and business relationships
common to companies in a country or countries other than an emerging country. As
a result, the value of the securities of such companies may reflect economic and
market forces applicable to other countries, as well as to an emerging country.
The Adviser believes, however, that investment in such companies will be
appropriate because the Portfolio intends to invest only in those companies
which, in its view, have sufficiently strong exposure to economic and market
forces in an emerging country that their value will tend to reflect developments
in such emerging country to a greater extent than developments in another
country or countries. For example, a Portfolio may invest in companies organized
and located in countries other than an emerging country, including companies
having their entire production facilities outside of an emerging country, when
securities of such companies meet one or more elements of the Portfolio's
definition of an emerging country equity or debt security and so long as the
Adviser believes at the time of investment that the value of the company's
securities principally reflects conditions in such emerging country.
 
    Investments in emerging country government fixed income securities involve
special risks. Certain emerging countries have historically experienced, and may
continue to experience, high rates of inflation, high interest rates, currency
exchange rate fluctuations, large amounts of external debt, balance of payments
and trade difficulties and extreme poverty and unemployment. The issuer or
governmental authority that controls the repayment of an emerging country's debt
may be unable or unwilling to repay the principal and/or interest when due in
accordance with the terms of such debt. As a result, emerging country government
obligors may be more likely to default on their obligations. If such an event
occurs, a Portfolio may have limited legal recourse against the issuer and/or
guarantor. Remedies must, in some cases, be pursued in the courts of the
defaulting party itself, and the ability of the holder of foreign government
debt securities to obtain recourse may be subject to the political climate in
the relevant country. In addition, no assurance can be given that the holders of
commercial bank debt will not contest payments to the holders of other foreign
government debt obligations in the event of default under their commercial bank
loan agreements.
 
    2
<PAGE>
EQUITY-LINKED SECURITIES
 
    Certain Portfolios may invest in equity-linked securities, including, among
others, PERCS, ELKS and LYONs, which are securities that are convertible into or
the value of which is based upon the value of equity securities upon certain
terms and conditions. The amount received by an investor at maturity of such
securities is not fixed but is based on the price of the underlying common
stock. It is impossible to predict whether the price of the underlying common
stock will rise or fall. Trading prices of the underlying common stock will be
influenced by the issuer's operational results, by complex, interrelated
political, economic, financial, or other factors affecting the capital markets,
the stock exchanges on which the underlying common stock is traded and the
market segment of which the issuer is a part. In addition, it is not possible to
predict how equity-linked securities will trade in the secondary market,
although the market for such securities is fairly developed and generally
liquid. The market for such securities may be shallow, however, and high volume
trades may be possible only with discounting. In addition to the foregoing
risks, the return on such securities depends on the creditworthiness of the
issuer of the securities, which may be the issuer of the underlying securities
or a third party investment banker or other lender. The creditworthiness of such
third party issuer of equity-linked securities may, and often does, exceed the
creditworthiness of the issuer of the underlying securities. The advantage of
using equity-linked securities over traditional equity and debt securities is
that equity-linked securities are income producing vehicles that may provide a
higher income than the dividend income on the underlying equity securities while
allowing some participation in the capital appreciation of the underlying equity
securities. Another advantage of using equity-linked securities is that they may
be used for hedging to reduce the risk of investing in the generally more
volatile underlying equity securities.
 
    The following are three examples of equity-linked securities. The Portfolios
may invest in the securities described below or other similar equity-linked
securities.
 
    PERCS.  Preferred Equity Redemption Cumulative Stock ("PERCS") technically
is preferred stock with some characteristics of common stock. PERCS are
mandatorily converted into common stock after a period of time, usually three
years, during which the investors' capital gains are capped, usually at 30%.
Commonly, PERCS may be redeemed by the issuer at any time or if the issuer's
common stock is trading at a specified price level or better. The redemption
price starts at the beginning of the PERCS duration period at a price that is
above the cap by the amount of the extra dividends the PERCS holder is entitled
to receive relative to the common stock over the duration of the PERCS and
declines to the cap price shortly before maturity of the PERCS. In exchange for
having the cap on capital gains and giving the issuer the option to redeem the
PERCS at any time or at the specified common stock price level, a Portfolio may
be compensated with a substantially higher dividend yield than that on the
underlying common stock. Investors that seek current income find PERCS
attractive because PERCS provide a higher dividend income than that paid with
respect to a company's common stock.
 
    ELKS.  Equity-Linked Securities ("ELKS") differ from ordinary debt
securities, in that the principal amount received at maturity is not fixed but
is based on the price of the issuer's common stock. ELKS are debt securities
commonly issued in fully registered form for a term of three years under an
indenture trust. At maturity, the holder of ELKS will be entitled to receive a
principal amount equal to the lesser of a cap amount, commonly in the range of
30% to 55% greater than the current price of the issuer's common stock, or the
average closing price per share of the issuer's common stock, subject to
adjustment as a result of certain dilution events, for the 10 trading days
immediately prior to maturity. Unlike PERCS, ELKS are commonly not subject to
redemption prior to maturity. ELKS usually bear interest during the three-year
term at a substantially higher rate than the dividend yield on the underlying
common stock. In exchange for having the cap on the return that might have been
received as capital gains on the underlying common stock, a Portfolio may be
compensated with higher yield, contingent on how well the underlying common
stock does. Investors that seek current income find ELKS attractive because ELKS
provide a higher dividend income than that paid with respect to a company's
common stock.
 
    LYONS.  Liquid Yield Option Notes ("LYONs") differ from ordinary debt
securities, in that the amount received prior to maturity is not fixed but is
based on the price of the issuer's common stock. LYONs are zero-coupon notes
that sell at a large discount from face value. LYONs generally do not pay any
interest until the notes mature, typically in 15 to 20 years, when the notes are
redeemed at face, or par, value. The yield on LYONs, typically, is
lower-than-market rate for debt securities of the same maturity, due in part to
the fact that the LYONs are convertible into common stock of the issuer at any
time at the option of the holder of the LYON. Commonly, the LYONs are redeemable
by the issuer at any time after an initial period or if the issuer's common
stock is trading at a specified price level or better or, at the option of the
holder, on certain fixed dates. The redemption price typically is the purchase
price of the LYON plus accrued original issue discount to the date of
redemption, which amounts to the lower-than-market yield. An investor will
receive only the lower-than-market yield unless the underlying common stock
increases in value at a substantial rate. LYONs are attractive when it appears
that they will increase in value due to the rise in value of the underlying
common stock.
 
EUROPEAN CURRENCY TRANSITION
 
    On January 1, 1999, the European Monetary Union (EMU) plans to implement a
new currency unit, the Euro, which is expected to reshape financial markets,
banking systems and monetary policies in Europe and other parts of the world.
Implementation of this plan will mean that financial transactions and market
information, including share quotations and
 
                                                                           3
<PAGE>
company accounts, in participating countries will be denominated in Euros.
Monetary policy for participating countries will be uniformly managed by a new
central bank, the European Central Bank (ECB).
 
    The transition to the Euro may change the economic environment and behavior
of investors, particularly in European markets. For example, the process of
implementing the Euro may adversely affect financial markets world-wide and may
result in changes in the relative strength and value of the U.S. dollar or other
major currencies, as well as possible adverse tax consequences. The transition
to the Euro is likely to have a significant impact on fiscal and monetary policy
in the participating countries and may produce unpredictable effects on trade
and commerce generally. These resulting uncertainties could create increased
volatility in financial markets world-wide.
 
FIXED INCOME SECURITIES
 
    The market value of fixed income or debt securities held by a Portfolio
generally will vary inversely with changes in prevailing interest rates. Each
Portfolio will be subject to credit risk and market risk associated with
investment in fixed income securities. Credit risk is the possibility that an
issuer may be unable to meet scheduled principal and interest payments. Market
risk is the possibility that a change in interest rates or the market's
perception of the issuer's prospects may adversely affect the value of a fixed
income security. When interest rates are falling, the inflow of net new money to
a Portfolio will likely have to be invested in instruments producing lower
yields, thereby reducing portfolio income. While securities with longer
maturities tend to produce higher yields, the prices of longer maturity
securities are subject to greater market fluctuations as a result of changes in
interest rates.
 
FOREIGN CURRENCY FORWARD CONTRACTS
 
    The U.S. dollar value of the assets of the Portfolios, to the extent they
invest in securities denominated in foreign currencies, may be affected
favorably or unfavorably by changes in foreign currency exchange rates and
exchange control regulations, and the Portfolios may incur costs in connection
with conversions between various currencies. The Portfolios may conduct their
foreign currency exchange transactions either on a spot (i.e., cash) basis at
the spot rate prevailing in the foreign currency exchange market, but also may
enter into forward contracts to purchase or sell foreign currencies. A foreign
currency forward contract involves an obligation to purchase or sell a specific
currency at a future date, which may be any fixed number of days from the date
of the contract agreed upon by the parties, at a price set at the time of the
contract. These contracts are traded in the interbank market conducted directly
between currency traders (usually large commercial banks) and their customers. A
forward contract generally has no deposit requirement, and no commissions are
charged at any stage for such trades.
 
    The Portfolios may enter into foreign currency forward contracts in several
circumstances. When a Portfolio enters into a contract for the purchase or sale
of a security denominated in a foreign currency, or when a Portfolio anticipates
the receipt in a foreign currency of dividends or interest payments on a
security which it holds, the Portfolio may desire to "lock-in" the U.S. dollar
price of the security or the U.S. dollar equivalent of such dividend or interest
payment, as the case may be. By entering into a forward contract for a fixed
amount of dollars, for the purchase or sale of the amount of foreign currency
involved in the underlying transactions, the Portfolio will be able to protect
itself against a possible loss resulting from an adverse change in the
relationship between the U.S. dollar and the subject foreign currency during the
period between the date on which the security is purchased or sold, or on which
the dividend or interest payment is declared, and the date on which such
payments are made or received. Additionally, when any of the Portfolios
anticipates that the currency of a particular foreign country may suffer a
substantial decline against the U.S. dollar, it may enter into a forward
contract for a fixed amount of dollars, to sell the amount of foreign currency
approximating the value of some or all of such Portfolio's securities
denominated in such foreign currency.
 
    The precise matching of the forward contract amounts and the value of the
securities involved will not generally be possible since the future value of
securities in foreign currencies will change as a consequence of market
movements in the value of these securities between the date on which the forward
contract is entered into and the date it matures. The projection of short-term
currency market movement is extremely difficult, and the successful execution of
a short-term hedging strategy is highly uncertain. None of the Portfolios intend
to enter into such forward contracts to protect the value of portfolio
securities on a continuous basis. The Portfolios will not enter into such
forward contracts or maintain a net exposure to such contracts where the
consummation of the contracts would obligate such Portfolio to deliver an amount
of foreign currency in excess of the value of such Portfolio's securities or
other assets denominated in that currency.
 
    Under normal circumstances, consideration of the prospect for currency
parities will be incorporated into the long-term investment decisions made with
regard to overall diversification strategies. However, the management of the
Fund believes that it is important to have the flexibility to enter into such
forward contracts when it determines that the best interests of the performance
of each Portfolio will thereby be served. Except under circumstances where a
segregated account is not required under the Investment Company Act of 1940, as
amended (the "1940 Act") or the rules adopted thereunder, the Fund's Custodian
will place cash or liquid securities into a segregated account of a Portfolio in
an amount equal to the value of such Portfolio's total assets committed to the
consummation of forward currency exchange contracts. If the value of the
securities
 
    4
<PAGE>
placed in the segregated account declines, additional cash or securities will be
placed in the account on a daily basis so that the value of the account will be
equal to the amount of such Portfolio's commitments with respect to such
contracts.
 
    The Portfolios generally will not enter into a forward contract with a term
of greater than one year. At the maturity of a forward contract, a Portfolio may
either sell the portfolio security and make delivery of the foreign currency, or
it may retain the security and terminate its contractual obligation to deliver
the foreign currency by purchasing an "offsetting" contract with the same
currency trader obligating it to purchase, on the same maturity date, the same
amount of the foreign currency.
 
    It is impossible to forecast with absolute precision the market value of a
particular portfolio security at the expiration of the contract. Accordingly, it
may be necessary for a Portfolio to purchase additional foreign currency on the
spot market (and bear the expense of such purchase) if the market value of the
security is less than the amount of foreign currency that such Portfolio is
obligated to deliver and if a decision is made to sell the security and make
delivery of the foreign currency.
 
    If a Portfolio retains the portfolio security and engages in an offsetting
transaction, such Portfolio will incur a gain or a loss (as described below) to
the extent that there has been movement in forward contract prices. Should
forward prices decline during the period between a Portfolio entering into a
forward contract for the sale of a foreign currency and the date it enters into
an offsetting contract for the purchase of the foreign currency, such Portfolio
will realize a gain to the extent that the price of the currency it has agreed
to sell exceeds the price of the currency it has agreed to purchase. Should
forward prices increase, such Portfolio would suffer a loss to the extent that
the price of the currency it has agreed to purchase exceeds the price of the
currency it has agreed to sell.
 
    The Portfolios are not required to enter into such transactions with regard
to their foreign currency-denominated securities. It also should be realized
that this method of protecting the value of portfolio securities against a
decline in the value of a currency does not eliminate fluctuations in the
underlying prices of the securities. It simply establishes a rate of exchange
which one can achieve at some future point in time. Additionally, although such
contracts tend to minimize the risk of loss due to a decline in the value of the
hedged currency, at the same time, they tend to limit any potential gain which
might result should the value of such currency increase. For a discussion of the
special risks associated with foreign currency transactions, see "Risks
Associated with Foreign Currency Transactions," below in this SAI.
 
RISKS ASSOCIATED WITH FOREIGN CURRENCY TRANSACTIONS
 
    Transactions in foreign currency forward contracts, foreign currency futures
contracts and options thereon, and options on foreign currencies, are subject to
the risk of governmental actions affecting trading in or the prices of
currencies underlying such contracts, which could restrict or eliminate trading
and could have a substantial adverse effect on the value of positions held by
the Portfolios permitted to engage in such hedging transactions. In addition,
the value of such positions could be adversely affected by a number of other
complex political and economic factors applicable to the countries issuing the
underlying currencies.
 
    Furthermore, unlike trading in most other types of instruments, there is no
systematic reporting of last sale information with respect to the foreign
currencies underlying forward contracts, futures contracts and options. As a
result, the available information on which a Portfolio's trading systems will be
based may not be as complete as the comparable data on which such Portfolio
makes investment and trading decisions in connection with securities and other
transactions. Moreover, because the foreign currency market is a global,
twenty-four hour market, events could occur on that market which will not be
reflected in the forward, futures or options markets until the following day,
thereby preventing a Portfolio from responding to such events in a timely
manner.
 
    Settlement of over-the-counter ("OTC") forward contracts or the exercise of
foreign currency options generally must occur within the country issuing the
underlying currency, which in turn requires parties to such contracts to accept
or make delivery of such currencies in conformity with any United States or
foreign restrictions and regulations regarding the maintenance of foreign
banking relationships, fees, taxes or other charges.
 
    Unlike currency futures contracts and exchange-traded options, OTC options
on foreign currencies and foreign currency forward contracts are not traded on
contract markets or national securities exchanges regulated by the Commodity
Futures Trading Commission ("CFTC") or the Securities and Exchange Commission
(the "Commission"), respectively. In an OTC trading environment, many of the
protections associated with transactions on exchanges will not be available.
 
    For example, there are no daily price fluctuation limits, and adverse market
movements could therefore continue to an unlimited extent over a period of time.
Although the purchaser of an option cannot lose more than the amount of the
premium plus related transaction costs, this entire amount could be lost.
Moreover, an option writer could lose amounts substantially in excess of its
initial investment due to the margin and collateral requirements associated with
such option positions. Similarly, there is no limit on the amount of potential
losses on forward contracts to which a Portfolio is a party.
 
    In addition, OTC transactions can only be entered into with a financial
institution willing to take the opposite side, as principal, of a Portfolio's
position unless the institution acts as broker and is able to find another
counterparty willing to enter into the transaction with such Portfolio. Where no
such counterparty is available, it will not be possible to enter into a desired
transaction. There also may be no liquid secondary market in the trading of OTC
contracts, and a Portfolio may be unable to
 
                                                                           5
<PAGE>
close out options purchased or written, or forward contracts entered into, until
their exercise, expiration or maturity. This, in turn, could limit a Portfolio's
ability to realize profits or to reduce losses on open positions and could
result in greater losses.
 
    Furthermore, OTC transactions are not backed by the guarantee of an
exchange's clearing corporation. A Portfolio will therefore be subject to the
risk of default by, or the bankruptcy of, the financial institution serving as
its counterparty. One or more of such institutions also may decide to
discontinue its role as market-maker in a particular currency, thereby
restricting a Portfolio's ability to enter into desired hedging transactions. A
Portfolio will enter into OTC transactions only with parties whose
creditworthiness has been reviewed and found satisfactory by the Adviser.
 
    OTC options on foreign currencies are within the exclusive regulatory
jurisdiction of the CFTC. The CFTC currently permits the trading of such
options, but only subject to a number of conditions regarding the commercial
purpose of the purchaser of such options. The Portfolios are not able to
determine at this time whether or to what extent the CFTC may impose additional
restrictions on the trading of over-the-counter options on foreign currencies at
some point in the future, or the effect that any restrictions may have on the
hedging strategies to be implemented by the Portfolios. Forward contracts and
currency swaps are not presently subject to regulation by the CFTC, although the
CFTC may in the future assert or be granted authority to regulate such
instruments. In such event, a Portfolio's ability to utilize forward contracts
and currency swaps in the manner set forth above and in the applicable
Prospectus could be restricted.
 
    Options on foreign currencies traded on a national securities exchange are
within the jurisdiction of the Commission, as are other securities traded on
such exchanges. As a result, many of the protections provided to traders on
organized exchanges will be available with respect to such transactions. In
particular, all foreign currency options positions entered into on a national
securities exchange are cleared and guaranteed by the Options Clearing
Corporation ("OCC"), thereby reducing the risk of counterparty default. Further,
a liquid secondary market in options traded on a national securities exchange
may be more readily available than in the OTC market, potentially permitting a
Portfolio to liquidate open positions at a profit prior to exercise or
expiration, or to limit losses in the event of adverse market movements.
 
    The purchase and sale of exchange-traded foreign currency options, however,
is subject to the risks of the availability of a liquid secondary market
described above, as well as the risks regarding adverse market movements,
margining of options written, the nature of the foreign currency market,
possible intervention by governmental authorities and the effect of other
political and economic events. In addition, exchange-traded options on foreign
currencies involve certain risks not presented by the over-the-counter market.
For example, exercise and settlement of such options must be made exclusively
through the OCC, which has established banking relationships in applicable
foreign countries for this purpose. As a result, the OCC may, if it determines
that foreign governmental restrictions or taxes would prevent the orderly
settlement of foreign currency option exercises, or would result in undue
burdens on the OCC or its clearing members, impose special procedures for
exercise and settlement, such as technical changes in the mechanics of delivery
of currency, the fixing of dollar settlement prices or prohibitions on exercise.
 
FOREIGN INVESTMENTS
 
    Certain Portfolios may invest in securities of foreign issuers. Investing in
such foreign securities involves special considerations that are not typically
associated with investing in U.S. issuers. In addition to the effect on the
Portfolios of currency exchange rate fluctuation discussed under "Foreign
Currency Forward Contracts" above, foreign issuers may not be subject to uniform
accounting, auditing and financial reporting standards and may have policies
that are not comparable to those of domestic issuers. Accordingly, there may be
less information available about certain foreign companies than about domestic
issuers and domestic markets. Securities of some foreign issuers and foreign
markets are generally less liquid and more volatile than securities of
comparable domestic issuers. There is generally less government supervision and
regulation of stock exchanges, brokers and listed issuers than in the United
States. In addition, with respect to certain foreign countries, there is the
possibility of expropriation or confiscatory taxation, political or social
instability, or diplomatic developments which could affect Portfolio investments
in those countries. Foreign securities not listed on a recognized domestic or
foreign exchange may not be readily marketable and, if so, such investments will
be limited to 15% of a Portfolio's net asset value at the time of purchase.
 
    Although the Portfolios will endeavor to achieve the most favorable
execution costs in their portfolio transactions, fixed commissions on many
foreign stock exchanges are generally higher than negotiated commissions on U.S.
exchanges.
 
FUTURES CONTRACTS
 
    Certain Portfolios may enter into futures contracts and options on futures
contracts. Futures contracts provide for the future sale by one party and
purchase by another party of a specified amount of a specific security at a
specified future time and at a specified price. Futures contracts, which are
standardized as to maturity date and underlying financial instrument, are traded
on national futures exchanges. Futures exchanges and trading are regulated under
the Commodity Exchange Act by the CFTC.
 
    Although futures contracts by their terms call for actual delivery or
acceptance of the underlying securities or currencies, in most cases the
contracts are closed out before the settlement date without the making or taking
of delivery. Closing out an
 
    6
<PAGE>
open futures position is done by taking an opposite position ("buying" a
contract which has previously been "sold" or "selling" a contract previously
"purchased") in an identical contract to terminate the position. Brokerage
commissions are incurred when a futures contract is bought or sold.
 
    Futures contracts on securities indices or other indices do not require the
physical delivery of securities, but merely provide for profits and losses
resulting from changes in the market value of a contract to be credited or
debited at the close of each trading day to the respective accounts of the
parties to the contract. On the contract's expiration date a final cash
settlement occurs and the futures position is simply closed out. Changes in the
market value of a particular futures contract reflect changes in the level of
the index on which the futures contract is based.
 
    Futures traders are required to make a good faith margin deposit in cash or
government securities with a broker or custodian to initiate and maintain open
positions in futures contracts. A margin deposit is intended to assure
completion of the contract (delivery or acceptance of the underlying security)
if it is not terminated prior to the specified delivery date. Minimal initial
margin requirements are established by the futures exchange and may be changed.
Brokers may establish deposit requirements which are higher than the exchange
minimums. Futures contracts are customarily purchased and sold for prices that
may range upward from less than 5% of the value of the contract being traded.
 
    After a futures contract position is opened, the value of the contract is
marked to market daily. If the futures contract price changes to the extent that
the margin on deposit does not satisfy margin requirements, payment of an
additional "variation" margin will be required. Conversely, a change in the
contract value may reduce the required margin, resulting in a repayment of
excess margin to the contract holder. Variation margin payments are made to and
from the futures broker for as long as the contract remains open. The Portfolios
expect to earn interest income on their margin deposits. With respect to each
long position in a futures contract or option thereon, the underlying commodity
value of such contract will always be covered by cash and cash equivalents set
aside plus accrued profits held at the futures commission merchant.
 
    Portfolios may purchase and write call and put options on futures contracts
which are traded on a U.S. Exchange or on any recognized securities or futures
exchange to the extent permitted by the CFTC and enter into closing transactions
with respect to such options to terminate an existing position. An option on a
futures contract gives the purchaser the right (in return for the premium paid)
to assume a position in a futures contract (a long position if the option is a
call and a short position if the option is a put) at a specified exercise price
at any time during the term of the option. Upon exercise of the option, the
delivery of the futures position by the writer of the option to the holder of
the option will be accompanied by delivery of the accumulated balance in the
writer's futures margin account, which represents the amount by which the market
price of the futures contract exceeds, in the case of a call, or is less than,
in the case of a put, the exercise price of the option on the futures contract.
 
    The Portfolios will purchase and write options on futures contracts for
identical purposes to those set forth above for the purchase of a futures
contract (purchase of a call option or sale of a put option) and the sale of a
futures contract (purchase of a put option or sale of a call option), or to
close out a long or short position in futures contracts.
 
    Traders in futures contracts may be broadly classified as either "hedgers"
or "speculators." Hedgers use the futures markets primarily to offset
unfavorable changes in the value of securities otherwise held for investment
purposes or expected to be acquired by them. Speculators are less inclined to
own the underlying securities with futures contracts which they trade, and use
futures contracts with the expectation of realizing profits from market
fluctuations. The Portfolios intend to use futures contracts only for hedging
purposes.
 
    Regulations of the CFTC applicable to the Portfolios require that all
futures transactions constitute bona fide hedging transactions except that a
Portfolio may engage in futures transactions that do not constitute bona fide
hedging to the extent that not more than 5% of the liquidation value of a
Portfolio's total assets are required as margin deposits or premiums for such
transactions. The Portfolios will only sell futures contracts to protect
securities owned against declines in price or purchase contracts to protect
against an increase in the price of securities intended for purchase. As
evidence of this hedging interest, the Portfolios expect that approximately 75%
of their futures contracts will be "completed"; that is, equivalent amounts of
related securities will have been purchased or are being purchased by the
Portfolios upon sale of open futures contracts.
 
    Although techniques other than the sale and purchase of futures contracts
could be used to control the Portfolios' exposure to market fluctuations, the
use of futures contracts may be a more effective means of hedging this exposure.
While the Portfolios will incur commission expenses in both opening and closing
out futures positions, these costs are lower than transaction costs incurred in
the purchase and sale of the underlying securities.
 
    RESTRICTIONS ON THE USE OF FUTURES CONTRACTS.  None of the Portfolios will
enter into futures contract transactions to the extent that, immediately
thereafter, the sum of its initial margin deposits on open contracts exceeds 5%
of the market value of its total assets. In addition, each Portfolio will limit
its use of derivative instruments, including futures contracts, to 33 1/3% of
its total assets measured by the aggregate notional amount of outstanding
derivative instruments.
 
    RISK FACTORS IN FUTURES TRANSACTIONS.  Positions in futures contracts may be
closed out only on an exchange which provides a secondary market for such
futures. However, there can be no assurance that a liquid secondary market will
exist for any
 
                                                                           7
<PAGE>
particular futures contracts at any specific time. Thus, it may not be possible
to close a futures position. In the event of adverse price movements, the
Portfolios would continue to be required to make daily cash payments to maintain
their required margin. In such situations, if a Portfolio has insufficient cash,
it may have to sell portfolio securities to meet its daily margin requirement at
a time when it may be disadvantageous to do so. In addition, a Portfolio may be
required to make delivery of the instruments underlying futures contracts it
holds. The inability to close options and futures positions also could have an
adverse impact on the Portfolio's ability to effectively hedge.
 
    The Portfolios will minimize the risk that they will be unable to close out
a futures contract by generally entering into futures which are traded on
recognized international or national futures exchanges and for which there
appears to be a liquid secondary market, however the Portfolios may enter into
over-the-counter futures transactions to the extent permitted by applicable law.
 
    The risk of loss in trading futures contracts in some strategies can be
substantial, due both to the low margin deposits required, and the extremely
high degree of leverage involved in futures pricing. As a result, a relatively
small price movement in a futures contract may result in immediate and
substantial loss (as well as gain) to the investor. For example, if, at the time
of purchase, 10% of the value of the futures contract is deposited as margin, a
subsequent 10% decrease in the value of the futures contract would result in a
total loss of the margin deposit, before any deduction for the transaction
costs, if the account were then closed out. A 15% decrease would result in a
loss equal to 150% of the original margin deposit if the contract were closed
out. Thus, a purchase or sale of a futures contract may result in losses in
excess of the amount invested in the contract. However, because the Portfolios
engage in futures strategies only for hedging purposes, the Adviser does not
believe that the Portfolios are subject to the risks of loss frequently
associated with futures transactions. A Portfolio would presumably have
sustained comparable losses if, instead of the futures contract, it had invested
in the underlying security or currency and sold it after the decline.
 
    Utilization of futures transactions by the Portfolios does involve the risk
of imperfect or no correlation where the securities underlying futures contracts
have different maturities than the portfolio securities or currencies being
hedged. It is also possible that a Portfolio could both lose money on futures
contracts and also experience a decline in value of its portfolio securities.
There is also the risk of loss by a Portfolio of margin deposits in the event of
bankruptcy of a broker with whom the Portfolio has an open position in a futures
contract or related option.
 
    Most futures exchanges limit the amount of fluctuation permitted in futures
contract prices during a single trading day. The daily limit establishes the
maximum amount that the price of a futures contract may vary either up or down
from the previous day's settlement price at the end of a trading session. Once
the daily limit has been reached in a particular type of contract, no trades may
be made on that day at a price beyond that limit. The daily limit governs only
price movement during a particular trading day and therefore does not limit
potential losses, because the limit may prevent the liquidation of unfavorable
positions. Futures contract prices have occasionally moved to the daily limit
for several consecutive trading days with little or no trading, thereby
preventing prompt liquidation of futures positions and subjecting some futures
traders to substantial losses. For a discussion of the special risks associated
with foreign currency transactions, see "Risks Associated with Foreign Currency
Transactions" in this SAI.
 
HIGH YIELD SECURITIES
 
    The market for lower rated and unrated debt securities, also known as "high
yield securities" or "junk bonds", is relatively new and its recent growth
paralleled a long period of economic expansion and an increase in merger,
acquisition and leveraged buyout activity. Adverse economic developments may
disrupt the market for U.S. corporate lower rated and unrated debt securities
and for emerging country debt securities. Such disruptions may severely affect
the ability of issuers, especially highly leveraged issuers, to service their
debt obligations or to repay their obligations upon maturity. In addition, the
secondary market for lower rated and unrated debt securities, which is
concentrated in relatively few market makers, may not be as liquid as the
secondary market for more highly rated securities. As a result, the Adviser
could find it more difficult to sell these securities or may be able to sell the
securities only at prices lower than if such securities were widely traded. In
addition there may be limited trading markets for debt securities of issuers
located in emerging countries. Prices realized upon the sale of such lower rated
or unrated securities, under these circumstances, may be less than the prices
used in calculating a Portfolio's net asset value.
 
    Prices for lower rated and unrated debt securities may be affected by
legislative and regulatory developments. These laws could adversely affect a
Portfolio's net asset value and investment practices, the secondary market for
lower rated and unrated debt securities, the financial condition of issuers of
such securities and the value of outstanding lower rated and unrated debt
securities. For example, U.S. federal legislation requiring the divestiture by
federally insured savings and loan associations of their investments in lower
rated and unrated debt securities and limiting the deductibility of interest by
certain corporate issuers of lower rated and unrated debt securities has
adversely affected the market in recent years.
 
    Lower rated or unrated debt obligations also present risks based on payment
expectations. If an issuer calls the obligations for redemption, a Portfolio may
have to replace the security with a lower yielding security, resulting in a
decreased return for investors. If a Portfolio experiences unexpected net
redemptions, it may be forced to sell its higher rated securities,
 
    8
<PAGE>
resulting in a decline in the overall credit quality of a Portfolio's investment
portfolio and increasing the exposure of a Portfolio to the risks of lower rated
and unrated debt securities.
 
LOAN PARTICIPATIONS AND ASSIGNMENTS
 
    Certain Portfolios may invest in fixed and floating rate loans ("Loans")
arranged through private negotiations between an issuer of sovereign debt
obligations and one or more financial institutions ("Lenders"). The Portfolio's
investments in Loans are expected in most instances to be in the form of
participations in Loans ("Participations") and assignments of all or a portion
of Loans ("Assignments") from third parties. The Portfolio's investment in
Participations typically will result in the Portfolio having a contractual
relationship only with the Lender and not with the borrower. The Portfolio will
have the right to receive payments of principal, interest and any fees to which
it is entitled only from the Lender selling the Participation and only upon
receipt by the Lender of the payments from the borrower. In connection with
purchasing Participations, the Portfolio generally will have no right to enforce
compliance by the borrower with the terms of the loan agreement relating to the
Loan, nor any rights of set-off against the borrower, and the Portfolio may not
directly benefit from any collateral supporting the underlying Loan. As a
result, the Portfolio may be subject to the credit risk of both the borrower and
the Lender that is selling the Participation. In the event of the insolvency of
the Lender selling a Participation, the Portfolio may be treated as a general
creditor of the Lender and may not benefit from any set-off between the Lender
and the borrower. Certain Participations may be structured in a manner designed
to avoid purchasers of Participations being subject to the credit risk of the
Lender with respect to the Participation, but even under such a structure, in
the event of the Lender's insolvency, the Lender's servicing of the
Participation may be delayed and the assignability of the Participation
impaired. The Portfolio will acquire Participations only if the Lender
interpositioned between the Portfolio and the borrower is determined by the
Adviser to be creditworthy.
 
    When the Portfolio purchases Assignments from Lenders it will acquire direct
rights against the borrower on the Loan. Because Assignments are arranged
through private negotiations between potential assignees and potential
assignors, however, the rights and obligations acquired by the Portfolio as the
purchaser of an Assignment may differ from, and be more limited than, those held
by the assigning Lender. The assignability of certain sovereign debt obligations
is restricted by the governing documentation as to the nature of the assignee
such that the only way in which the Portfolio may acquire an interest in a Loan
is through a Participation and not an Assignment. The Portfolio may have
difficulty disposing of Assignments and Participations because to do so it will
have to assign such securities to a third party. Because there is no liquid
market for such securities, the Portfolio anticipates that such securities could
be sold only to a limited number of institutional investors. The lack of a
liquid secondary market may have an adverse impact on the value of such
securities and the Portfolio's ability to dispose of particular Assignments or
Participations when necessary to meet the Portfolio's liquidity needs or in
response to a specific economic event such as a deterioration in the
creditworthiness of the borrower. The lack of a liquid secondary market for
Assignments and Participations also may make it more difficult for the Portfolio
to assign a value to these securities for purposes of valuing the Portfolio's
securities and calculating its net asset value.
 
MORTGAGE RELATED SECURITIES
 
    Mortgage related securities are securities that, directly or indirectly,
represent a participation in, or are secured by and payable from, mortgage loans
on real property. Mortgage related securities include collateralized mortgage
obligations and mortgage-backed securities issued or guaranteed by agencies or
instrumentalities of the U.S. Government or by private sector entities.
 
    COLLATERALIZED MORTGAGE OBLIGATIONS.  Collateralized mortgage obligations
("CMOs") are debt obligations or multiclass pass-through certificates issued by
agencies or instrumentalities of the U.S. Government or by private originators
or investors in mortgage loans. They are backed by mortgage-backed securities
(discussed below) or whole loans (all such assets, the "Mortgage Assets") and
are evidenced by a series of bonds or certificates issued in multiple classes.
Each class of a CMO, often referred to as a "tranche," may be issued with a
specific fixed or floating coupon rate and has a stated maturity or final
scheduled distribution date. The principal and interest on the underlying
Mortgage Assets may be allocated among the several classes of a series of CMOs
in many ways. Interest is paid or accrues on CMOs on a monthly, quarterly or
semi-annual basis.
 
    CMOs may be issued by agencies or instrumentalities of the U.S. Government,
or by private originators of, or investors in, mortgage loans, including savings
and loan associations, mortgage bankers, commercial banks, investment banks and
special purpose subsidiaries of the foregoing. CMOs that are issued by private
sector entities and are backed by assets lacking a guarantee of an entity having
the credit status of a governmental agency or instrumentality are generally
structured with one or more types of credit enhancement as described below. An
issuer of CMOs may elect to be treated, for federal income tax purposes, as a
Real Estate Mortgage Investment Conduit (a "REMIC"). An issuer of CMOs issued
after 1991 must elect to be treated as a REMIC or it will be taxable as a
corporation under rules regarding taxable mortgage pools.
 
    The principal of and interest on the Mortgage Assets may be allocated among
the several classes of a CMO in many ways. The general goal in allocating cash
flows on Mortgage Assets to the various classes of a CMO is to create certain
tranches on which the expected cash flows have a higher degree of predictability
than the underlying Mortgage Assets. As a general matter, the more predictable
the cash flow is on a particular CMO tranche, the lower the anticipated yield
will be on that tranche at
 
                                                                           9
<PAGE>
the time of issuance relative to prevailing market yields on Mortgage Assets. As
part of the process of creating more predictable cash flows on certain tranches
of a CMO, one or more tranches generally must be created that absorb most of the
changes in the cash flows on the underlying Mortgage Assets. The yields on these
tranches are generally higher than prevailing market yields on other mortgage
related securities with similar average lives. Principal prepayments on the
underlying Mortgage Assets may cause the CMOs to be retired substantially
earlier than their stated maturities or final scheduled distribution dates.
Because of the uncertainty of the cash flows on these tranches, the market
prices of and yields on these tranches are more volatile. In addition, some
inverse floating rate obligation CMOs exhibit extreme sensitivity to changes in
prepayments. As a result, the yield to maturity of these CMOs is sensitive not
only to changes in interest rates, but also to changes in prepayment rates on
the related underlying Mortgage Assets.
 
    Included within the category of CMOs are PAC Bonds. PAC Bonds are a type of
CMO tranche or series designed to provide relatively predictable payments of
principal provided that, among other things, the actual prepayment experience on
the underlying mortgage loans falls within a predefined range. If the actual
prepayment experience on the underlying mortgage loans is at a rate faster or
slower than the predefined range or if deviations from other assumptions occur,
principal payments on the PAC Bond may be earlier or later than predicted. The
magnitude of the predefined range varies from one PAC Bond to another; a
narrower range increases the risk that prepayments on the PAC Bond will be
greater or smaller than predicted. Because of these features, PAC Bonds
generally are less subject to the risks of prepayment than are other types of
mortgage related securities.
 
    MORTGAGE-BACKED SECURITIES.  With mortgage-backed securities ("MBSs"), many
mortgagees' monthly payments to their lending institution are pooled together
and passed through to investors such as a Portfolio. The pools are assembled by
various governmental, Government-related and private organizations. A Portfolio
may invest in securities issued or guaranteed by Government National Mortgage
Association ("GNMA" or "Ginnie Mae"), Federal Home Loan Mortgage Corporation
("FHLMC" or Freddie Mac"), Fannie Mae, private issuers and other government
agencies. There can be no assurance that the private issuers can meet their
obligations under the policies. MBSs issued by non-agency issuers, whether or
not such securities are subject to guarantees, may entail greater risk. If there
is no guarantee provided by the issuer, MBSs purchased by a Portfolio will be
those which at the time of purchase are rated investment grade by one or more
nationally recognized statistical rating organizations ("NRSRO") or, if unrated,
are deemed by the Adviser to be of comparable quality.
 
    MBSs are issued or guaranteed by private sector originators of or investors
in mortgage loans and are structured similarly to governmental pass-through
securities. Because private pass-throughs typically lack a guarantee by an
entity having the credit status of a governmental agency or instrumentality,
they are generally structured with one or more types of credit enhancement
described below. Fannie Mae and FHLMC obligations are not backed by the full
faith and credit of the U.S. Government as GNMA certificates are, but Fannie Mae
and FHLMC securities are supported by the instrumentalities' right to borrow
from the U.S. Treasury. Each of GNMA, Fannie Mae and FHLMC guarantees timely
distributions of interest to certificate holders. Each of GNMA and Fannie Mae
also guarantees timely distributions of scheduled principal. FHLMC has in the
past guaranteed only the ultimate collection of principal of the underlying
mortgage loan; however, FHLMC has now issued MBSs (FHLMC Gold PCS) which also
guarantee timely payment of monthly principal reductions. Resolution Funding
Corporation ("REFCORP") obligations are backed, as to principal payments, by
zero coupon U.S. Treasury bonds, and as to interest payment, ultimately by the
U.S. Treasury. Obligations issued by such U.S. Governmental agencies and
instrumentalities are described more fully below.
 
    There are two methods of trading MBSs. A specified pool transaction is a
trade in which the pool number of the security to be delivered on the settlement
date is known at the time the trade is made. This is in contrast with the
typical MBS transaction, called a TBA (to be announced) transaction, in which
the type of MBS to be delivered is specified at the time of trade but the actual
pool numbers of the securities that will be delivered are not known at the time
of the trade. The pool numbers of the pools to be delivered at settlement will
be announced shortly before settlement takes place. The terms of the TBA trade
may be made more specific if desired. Generally, agency pass-through MBSs are
traded on a TBA basis.
 
    Like fixed income securities in general, MBSs will generally decline in
price when interest rates rise. Due to prepayment risk, rising interest rates
also tend to discourage refinancings of home mortgages, with the result that the
average life of MBSs held by a Portfolio may be lengthened. As average life
extends, price volatility generally increases. This extension of average life
causes the market price of the MBSs to decrease further than if their average
lives were fixed. However, when interest rates fall, mortgages may not enjoy as
large a gain in market value due to prepayment risk because additional mortgage
prepayments must be reinvested at lower interest rates. Faster prepayment will
shorten the average life and slower prepayments will lengthen it. However, it is
possible to determine what the range of that movement could be and to calculate
the effect that it will have on the price of the MBS. In selecting these MBSs,
the Adviser will look for those that offer a higher yield to compensate for any
variation in average maturity. If the underlying mortgage assets experience
greater than anticipated prepayments of principal, a Portfolio may fail to fully
recoup its initial investment in these securities, even if the security is in
one of the highest rating categories. A Portfolio may invest, without limit, in
MBSs issued by private issuers when the Adviser deems that the quality of the
investment, the quality of the issuer, and market conditions warrant such
investments. Securities issued by private issuers will be rated investment grade
by Moody's or S&P or be deemed by the Adviser to be of comparable investment
quality.
 
    10
<PAGE>
    FANNIE MAE CERTIFICATES.  Fannie Mae is a federally chartered and privately
owned corporation organized and existing under the Federal National Mortgage
Association Charter Act of 1938. The obligations of Fannie Mae are not backed by
the full faith and credit of the U.S. Government.
 
    Each Fannie Mae certificate represents a pro rata interest in one or more
pools of mortgage loans insured by the Federal Housing Administration under the
Housing Act, or Title V of the Housing Act of 1949 ("FHA Loans"), or guaranteed
by the Department of Veterans Affairs under the Servicemen's Readjustment Act of
1944, as amended ("VA Loans") or conventional mortgage loans (i.e., mortgage
loans that are not insured or guaranteed by any governmental agency) of the
following types: (i) fixed rate level payment mortgage loans; (ii) fixed rate
growing equity mortgage loans; (iii) fixed rate graduated payment mortgage
loans; (iv) variable rate California mortgage loans; (v) other adjustable rate
mortgage loans; and (vi) fixed rate and adjustable mortgage loans secured by
multi-family projects.
 
    FREDDIE MAC CERTIFICATES.  Freddie Mac is a corporate instrumentality of the
United States created pursuant to the Emergency Home Finance Act of 1970, as
amended (the "FHLMC Act"). The obligations of Freddie Mac are obligations solely
of Freddie Mac and are not backed by the full faith and credit of the U.S.
Government.
 
    Freddie Mac certificates represent a pro rata interest in a group of
mortgage loans (a "Freddie Mac Certificate group") purchased by Freddie Mac. The
mortgage loans underlying the Freddie Mac certificates consist of fixed rate or
adjustable rate mortgage loans with original terms to maturity of between ten
and thirty years, substantially all of which are secured by first liens on
one-to-four-family residential properties or multi-family projects. Each
mortgage loan must meet the applicable standards set forth in the FHLMC Act. A
Freddie Mac Certificate group may include whole loans, participation interests
in whole loans and undivided interests in whole loans and participations
comprising another Freddie Mac Certificate group.
 
    GINNIE MAE CERTIFICATES.  Ginnie Mae is a wholly-owned corporate
instrumentality of the United States within the Department of Housing and Urban
Development. The National Housing Act of 1934, as amended (the "Housing Act"),
authorizes Ginnie Mae to guarantee the timely payment of the principal of and
interest on certificates that are based on and backed by a pool of FHA Loans, VA
Loans or by pools of other eligible mortgage loans. The Housing Act provides
that the full faith and credit of the U.S. Government is pledged to the payment
of all amounts that may be required to be paid under any guaranty. In order to
meet its obligations under such guaranty, Ginnie Mae is authorized to borrow
from the U.S. Treasury with no limitations as to amount.
 
    Each Ginnie Mae certificate represents a pro rata interest in one or more of
the following types of mortgage loans: (i) fixed rate level payment mortgage
loans; (ii) fixed rate graduated payment mortgage loans; (iii) fixed rate
growing equity mortgage loans; (iv) fixed rate mortgage loans secured by
manufactured (mobile) homes; (v) mortgage loans on multi-family residential
properties under construction; (vi) mortgage loans on completed multi-family
projects; (vii) fixed rate mortgage loans as to which escrowed funds are used to
reduce the borrower's monthly payments during the early years of the mortgage
loans ("buydown" mortgage loans); (viii) mortgage loans that provide for
adjustments in payments based on periodical changes in interest rates or in
other payment terms of the mortgage loans; and (ix) mortgage-backed serial
notes. All of these mortgage loans will be FHA Loans or VA Loans and, except as
otherwise specified above, will be fully-amortizing loans secured by first liens
on one- to four-family housing units.
 
    CREDIT ENHANCEMENT.  Mortgage related securities are often backed by a pool
of assets representing the obligations of a number of different parties. To
lessen the effect of failure by obligors on underlying assets to make payments,
such securities may contain elements of credit support. Such credit support
falls into two categories: (i) liquidity protection, and (ii) protection against
losses resulting from ultimate default by an obligor on the underlying assets.
Liquidity protection generally refers to the provision of advances, typically by
the entity administering the pool of assets, to ensure that the pass-through of
payments due on the underlying pool occurs in a timely fashion. Protection
against losses resulting from ultimate default enhances the likelihood of
ultimate payment of the obligations on at least a portion of the assets in the
pool. Such protection may be provided through guarantees, insurance policies or
letters of credit obtained by the issuer or sponsor from third parties (referred
to herein as "third party credit support"), through various means of structuring
the transaction or through a combination of such approaches.
 
    The ratings of mortgage related securities for which third party credit
enhancement provides liquidity protection or protection against losses from
default are generally dependent upon the continued creditworthiness of the
provider of the credit enhancement. The ratings of such securities could be
subject to reduction in the event of deterioration in the creditworthiness of
the credit enhancement provider even in cases where the delinquency and loss
experience on the underlying pool of assets is better than expected.
 
    Examples of credit support arising out of the structure of the transaction
include "senior-subordinated securities" (multiple class securities with one or
more classes subordinate to other classes as to the payment of principal and
interest thereon, with defaults on the underlying assets being borne first by
the holders of the most subordinated class), creation of "reserve funds" (where
cash or investments, sometimes funded from a portion of the payments on the
underlying assets, are held in reserve against future losses) and
"over-collateralization" (where the scheduled payments on, or the principal
amount of, the underlying assets exceed those required to make payment of the
securities and pay any servicing or other fees). The degree of credit support
provided for each security is generally based on historical information with
respect to the level of credit risk associated with the underlying assets.
Delinquency or loss in excess of that which is anticipated could adversely
affect the return on an investment in such a security.
 
                                                                          11
<PAGE>
MORGAN STANLEY CAPITAL INTERNATIONAL EAFE INDEX
 
    The EAFE Index is one of seven International Indices, twenty National
Indices and thirty-eight International Industry Indices making up the Morgan
Stanley Capital International Indices. The EAFE Index is based on the share
prices of over 1,000 companies listed on the stock exchanges of Europe,
Australia, New Zealand and the Far East. "Europe" includes Austria, Belgium,
Denmark, Finland, France, Germany, Ireland, Italy, The Netherlands, Norway,
Portugal, Spain, Sweden, Switzerland and the United Kingdom. "Far East" includes
Japan, Hong Kong and Singapore/Malaysia.
 
MUNICIPAL BONDS
 
    Municipal Bonds generally include debt obligations issued by states and
their political subdivisions, and duly constituted authorities and corporations,
to obtain funds to construct, repair or improve various public facilities such
as airports, bridges, highways, hospitals, housing, schools, streets and water
and sewer works. Municipal Bonds may also be issued to refinance outstanding
obligations as well as to obtain funds for general operating expenses and for
loans to other public institutions
and facilities.
 
    The two principal classifications of Municipal Bonds are "general
obligation" and "revenue" or "special tax" bonds. General obligation bonds are
secured by the issuer's pledge of its full faith, credit and taxing power for
the payment of principal and interest. Revenue or special tax bonds are payable
only from the revenues derived from a particular facility or class of facilities
or, in some cases, from the proceeds of a special excise or other tax, but not
from general tax revenues. A Portfolio may also invest in tax-exempt industrial
development bonds, short-term municipal obligations, project notes, demand notes
and tax-exempt commercial paper in accordance with the Portfolio's investment
objectives and policies.
 
    Industrial revenue bonds (i.e., private activity bonds) in most cases are
revenue bonds and generally do not have the pledge of the credit of the issuer.
The payment of the principal and interest on such industrial revenue bonds is
dependent solely on the ability of the user of the facilities financed by the
bonds to meet its financial obligations and the pledge, if any, of real and
personal property so financed as security for such payment. Short-term municipal
obligations issued by states, cities, municipalities or municipal agencies
include Tax Anticipation Notes, Revenue Anticipation Notes, Bond Anticipation
Notes, Construction Loan Notes and Short-Term Discount Notes. Project Notes are
instruments guaranteed by the Department of Housing and Urban Development but
issued by a state or local housing agency. While the issuing agency has the
primary obligation on such Project notes, they are also secured by the full
faith and credit of the United States.
 
    Note obligations with demand or put options may have a stated maturity in
excess of one year, but allow any holder to demand payment of principal plus
accrued interest upon a specified number of days notice. Frequently, such
obligations are secured by letters of credit or other credit support
arrangements provided by banks. The issuer of such notes normally has a
corresponding right, after a given period, to repay in its discretion the
outstanding principal of the notes plus accrued interest upon a specific number
of days notice to the bondholders. The interest rate on a demand note may be
based upon a known lending rate, such as a bank's prime rate, and may be
adjusted when such rate changes, or the interest rate on a demand note may be a
market rate that is adjusted at specified intervals. The demand notes in which
the Municipal Money Market Portfolio will invest are payable on not more than
one year's notice.
 
    The yields of Municipal Bonds depend on, among other things, general money
market conditions, conditions in the Municipal Bond market, the size of a
particular offering, the maturity of the obligation, and the rating of the
issue. The ratings of Moody's and S&P represent their opinions of the quality of
the Municipal Bonds and such ratings are general and are not absolute standards
of quality. Consequently, Municipal Bonds with the same maturity, coupon and
rating may have different yields, while Municipal Bonds of the same maturity and
coupon, but with different ratings, also may have the same yield. It will be the
responsibility of the Adviser to appraise independently the fundamental quality
of the bonds held by the Portfolios.
 
    Municipal Bonds are sometimes purchased on a "when issued" basis meaning the
buyer has committed to purchasing certain specified securities at an agreed-upon
price when they are issued. The period between commitment date and issuance date
can be a month or more. It is possible that the securities will never be issued
and the commitment canceled.
 
    From time to time proposals have been introduced before Congress to restrict
or eliminate the Federal income tax exemption for interest on Municipal Bonds.
Similarly, from time to time proposals have been introduced before State and
local legislatures to restrict or eliminate the State and local income tax
exemption (to the extent such an exemption applies, which may not apply in all
cases) for interest on Municipal Bonds. Similar proposals may be introduced in
the future. If any such proposal were enacted, it might restrict or eliminate
the ability of a Portfolio to achieve its investment objective. In that event,
the Fund's Directors and officers would reevaluate such Portfolio's investment
objective and policies and consider recommending changes to its shareholders.
 
OPTIONS TRANSACTIONS
 
    GENERAL INFORMATION.  Certain Portfolios may purchase and sell options on
portfolio securities and securities indices. Additional information with respect
to option transactions is set forth below. Call and put options on equity
securities are
 
    12
<PAGE>
listed on various U.S. and foreign securities exchanges ("listed options") and
are written in over-the-counter transactions ("OTC Options").
 
    Listed options are issued or guaranteed by the exchange on which they trade
or by a clearing corporation, such as Options Clearing Corporation ("OCC") in
the United States. Ownership of a listed call option gives the fund the right to
buy from the clearing corporation or exchange, the underlying security covered
by the option at the state exercise price (the price per unit of the underlying
security or currency) by filing an exercise notice prior to the expiration date
of the option. The writer (seller) of the option would then have the obligation
to sell to the clearing corporation or exchange, the underlying security or
currency at that exercise price prior to the expiration date of the option,
regardless of the current market price. Ownership of listed put option would
give the Portfolio the right to sell the underlying security or currency to the
clearing corporation or exchange at the state exercise price. Upon notice of
exercise of the put option, the writer of the option would have the obligation
to purchase the underlying security from the clearing corporation or exchange at
the exercise price.
 
    OTC options are purchased from or sold (written) to dealers of financial
institutions which have entered into direct agreements with the Portfolio. With
OTC options, such variables as expiration date, exercise price and premium will
be agreed upon between the Portfolio and the transactions dealer, without the
intermediation of a third party such as a clearing corporation or exchange. If
the transacting dealer fails to make or take delivery of the securities
underlying an option it has written, in accordance with the terms of that
option, the Portfolio would lose the premium paid for the option as well as any
anticipated benefit of the transaction.
 
    COVERED CALL WRITING.  The Portfolios may write (i.e., sell) covered call
options on portfolio securities. By doing so, the Portfolio would become
obligated during the terms of the option to deliver the securities underlying
the option should the option holder choose to exercise the option before the
option's termination date. In return for the call it has written, the Portfolio
will receive from the purchaser (or option holder) a premium which is the price
of the option, less a commission charged by a broker. The Portfolio will keep
the premium regardless of whether the option is exercised. A call option is
"covered" if the Portfolio owns the security underlying the option it has
written or has an absolute or immediate right to acquire the security by holding
a call option on such security, or maintains a sufficient amount of cash, cash
equivalents or liquid securities to purchase the underlying security. When the
Portfolio writes covered call options, it augments its income by the premiums
received and is thereby hedged to the extent of that amount against a decline in
the price of the underlying securities and the premiums received will offset a
portion of the potential loss incurred by the Portfolio if the securities
underlying the options are ultimately sold by the Portfolio at a loss. However,
during the option period, the Portfolio has, in return for the premium on the
option, given up the opportunity for capital appreciation above the exercise
price should the market price of the underlying security increase, but has
retained the risk of loss should the price of the underlying security decline.
The size of premiums will fluctuate with varying market conditions.
 
    COVERED PUT WRITING.  The Portfolios may write covered put options on
portfolio securities. By doing so, the Portfolio incurs an obligation to buy the
security underlying the option from the purchaser of the put at the option's
exercise price at any time during the option period, at the purchaser's election
(certain listed and OTC options written by the Portfolio will be exercisable by
the purchaser only on a specific date). Generally, a put option is "covered" if
the Portfolio maintains cash or other liquid securities equal to the exercise
price of the option or if the Portfolio holds a put option on the same
underlying security with a similar or higher exercise price.
 
    The Portfolios may write put options to receive the premiums paid by
purchasers; when the Adviser (and also the Sub-Adviser with respect to the Gold
Portfolio) wishes to purchase the security underlying the option at a price
lower than its current market price, in which case it will write the covered put
at an exercise price reflecting the lower purchase price sought; and to close
out long put option positions.
 
    PURCHASE OF PUT AND CALL OPTIONS.  When the Portfolio purchases a call
option it acquires the right to purchase a designated security at a designated
price (the "exercise price"), and when the Portfolio purchases a put option it
acquires the right to sell a designated security at the exercise price, in each
case on or before a specified date (the "termination date"), usually not more
than nine months from the date the option is issued.
 
    The Portfolio may purchase call options to close out a covered call position
or to protect against an increase in the price of a security it anticipates
purchasing. The Portfolio may purchase put options on securities which it holds
in its portfolio only to protect itself against a decline in the value of the
security. If the value of the underlying security were to fall below the
exercise price of the put purchased in an amount greater than the premium paid
for the option, the Portfolio would incur no additional loss. The Portfolio may
also purchase put options to close out written put positions in a manner similar
to call option closing purchase transactions.
 
    The amount the Portfolio pays to purchase an option is called a "premium",
and the risk assumed by the Portfolio when it purchases an option is the loss of
this premium. Because the price of an option tends to move with that of its
underlying security, if the Portfolio is to make a profit, the price of the
underlying security must change and the change must be sufficient to cover the
premium and commissions paid. A price change in the security underlying the
option does not assure a profit since prices in the options market may not
always reflect such a change.
 
                                                                          13
<PAGE>
    OPTIONS ON SECURITIES INDICES.  The Portfolios may purchase and write put
and call options on securities indices and enter into related closing
transactions in order to hedge against the risk of market price fluctuations or
to increase income
to the Portfolio.
 
    Call and put options on indices are similar to options on securities except
that, rather than the right to purchase or sell particular securities at a
specified price, options on an index give the holder the right to receive, upon
exercise of the option, an amount of cash if the closing level of the underlying
index is greater than (or less than, in the case of puts) the exercise price of
the option. This amount of cash is equal to the difference between the closing
price of the index and the exercise price of the option, expressed in dollars
multiplied by a specified number. Thus, unlike options on individual securities,
all settlements are in cash, and gain or loss depends on price movements in the
particular market represented by the index generally (or in a particular
industry or segment of the market) rather than the price movements in individual
securities.
 
    All options written on indices must be covered. When the Portfolio writes an
option on an index, it will establish a segregated account containing cash or
liquid securities with its custodian in an amount at least equal to the market
or value of the option and will maintain the account while the option is open or
will otherwise cover the transaction.
 
    The Portfolio may choose to terminate an option position by entering into a
closing transaction. The ability of the Portfolio to enter into closing
transactions depends upon the existence of a liquid secondary market for such
transactions.
 
    OPTIONS ON CURRENCIES.  The Portfolios may purchase and write put and call
options on foreign currencies (traded on U.S. and foreign exchanges or
over-the-counter markets) to manage the Portfolio's exposure to changes in
dollar exchange rates. Call options on foreign currency written by the Portfolio
will be "covered," which means that the Portfolio will own an equal amount of
the underlying foreign currency. With respect to put options on foreign currency
written by the Portfolio, the Portfolio will establish a segregated account with
the Fund's Custodian consisting of cash or liquid securities in an amount equal
to the amount the Portfolio would be required to pay upon exercise of the put.
 
    RISK FACTORS IN OPTIONS TRANSACTIONS.  The use of options also involves
additional risks. Compared to the purchase or sale of futures contracts, the
purchase of call or put options involves less potential risk to a Portfolio
because the maximum amount of risk is the premium paid for the option. The
writing of a call option generates a premium which may partially offset a
decline in the value of a Portfolio's portfolio assets. By writing a call
option, the Portfolio becomes obligated to sell the underlying instrument, which
may have a value higher than the exercise price. Conversely, the writing of a
put option generates a premium, but the Portfolio becomes obligated to purchase
the underlying instrument, which may have a value lower than the exercise price.
Thus, the loss incurred by a Portfolio in writing options may exceed the amount
of the premium received.
 
    The effective use of options strategies is dependent, among other things, on
a Portfolio's ability to terminate options positions at a time when the
portfolio manager deems it desirable to do so. Although a Portfolio will enter
into options positions only if the portfolio manager believes that a liquid
secondary market exists for such options, there is no assurance that the
Portfolio will be able to effect closing transactions at any particular time or
at an acceptable price.
 
    A Portfolio's purchase or sale of put or call options will be based upon
predictions as to anticipated market trends and/or interest rate movements by
the portfolio manager, which could prove to be inaccurate. Even if the
expectations of the portfolio manager are correct, there may be an imperfect
correlation between the change in the value of the options and of the
Portfolio's portfolio securities.
 
    The writer of an option may have no control over when the underlying
securities must be sold, in the case of a call option, or purchased, in the case
of a put option; the writer may be assigned an exercise notice at any time prior
to the termination of the obligation. Whether or not an option expires
unexercised, the writer retains the amount of the premium. This amount, of
course, may, in the case of a covered call option, be offset by a decline in the
market value of the underlying security during the option period. If a call
option is exercised, the writer experiences a profit or loss from the sale of
the underlying security. If a put option is exercised, the writer must fulfill
the obligation to purchase the underlying security at the exercise price which
will usually exceed the then market value of the underlying security.
 
    The writer of an option that wishes to terminate its obligation may effect a
"closing purchase transaction." This is accomplished by buying an option of the
same series as the option previously written. The effect of the purchase is that
the writer's position will be canceled by the clearing corporation. However, a
writer may not effect a closing purchase transaction after being notified of the
exercise of an option. Likewise, an investor who is the holder of an option may
liquidate its position by effecting a "closing sale transaction." This is
accomplished by selling an option of the same series as the option previously
purchased. There is no guarantee that either a closing purchase or a closing
sale transaction can be effected.
 
    Effecting a closing transaction in the case of a written call option will
permit the Portfolio to write another call option on the underlying security
with either a different exercise price or expiration date or both, in the case
of a written put option, will permit the Portfolio to write another put option
to the extent that the exercise price thereof is secured by depositing liquid
assets. Also, effecting a closing transaction will permit the cash or proceeds
from the concurrent sale of any securities subject to the option to be used for
other Portfolio investments. If the Portfolio desires to sell a particular
security from its portfolio on which it has written a call option, it will
effect a closing transaction prior to or concurrent with the sale of the
security.
 
    14
<PAGE>
    A Portfolio will realize a profit from a closing transaction if the price of
the transaction is less than the premium received from writing the option or is
more than the premium paid to purchase the option; the Portfolio will realize a
loss from a closing transaction if the price of the transaction is more than the
premium received from writing the option or is less than the premium paid to
purchase the option. Because increases in the market price of a call option will
generally reflect increases in the market price of the underlying security, any
loss resulting from the repurchase of a call option is likely to be offset in
whole or in part by appreciation of the underlying security owned by the
Portfolio.
 
    An options position may be closed out only where there exists a secondary
market for an option of the same series. If a secondary market does not exist,
it might be possible to effect a closing transaction in particular options with
the result that the Portfolio would have to exercise the options in order to
realize any profit. If the Portfolio is unable to effect a closing purchase
transaction in a secondary market, it will not be able to sell the underlying
security until the option expires or it delivers the underlying security upon
exercise. Reasons for the absence of a liquid secondary market include the
following: (i) there may be insufficient trading interest in certain options;
(ii) restrictions may be imposed by an exchange on opening transactions or
closing transactions, or both; (iii) trading halts, suspensions or other
restrictions may be imposed with respect to particular classes or series of
options or underlying securities; (iv) unusual or unforeseen circumstances may
interrupt normal operation on an exchange; (v) the facilities of an exchange or
OCC may not at all times be adequate to handle current trading volume; or (vi)
one or more exchange could, for economic or other reasons, decide or be
compelled at some future date to discontinue the trading of options (or a
particular class or series of options), in which event the secondary market on
that Exchange (or in that class or series of options) would cease to exist,
although outstanding options on that exchange that had been issued by OCC as a
result of trades on that exchange would continue to be exercisable in accordance
with their terms.
 
PORTFOLIO TURNOVER
 
    The portfolio turnover rate for a year is the lesser of the value of the
purchases or sales for the year divided by the average monthly market value of
the Portfolio for the year, excluding U.S. Government securities and securities
with maturities of one year or less. The portfolio turnover rate for a year is
calculated by dividing the lesser of sales or the average monthly value of the
Portfolio's portfolio purchases of portfolio securities during that year by
securities, excluding money market instruments. The rate of portfolio turnover
will not be a limiting factor when a Portfolio deems it appropriate to purchase
or sell securities for the Portfolio.
 
PRECIOUS METALS FORWARD AND FUTURES CONTRACTS AND OPTIONS ON FUTURES CONTRACTS
 
    The Gold Portfolio may enter into futures contacts on precious metals
("precious metals futures") as a hedge against changes in the prices of precious
metals held or intended to be acquired by the Portfolio, but not for speculation
or for achieving leverage. The Portfolio's hedging activities may include
purchases of futures contracts as an offset against the effect of anticipated
increases in the price of a precious metal which the Portfolio intends to
acquire ("anticipatory hedge") or sales of futures contracts as an offset
against the effect of anticipated declines in the price of precious metal which
the Portfolio owns ("hedge against an existing position").
 
    The Portfolio will enter into precious metals forward contracts which are
similar to precious metals futures contracts, in that they provide for the
purchase or sale of precious metals at an agreed price with delivery to take
place at an agreed future time. However, unlike futures contracts, forward
contracts are negotiated contracts which are primarily used in the dealer
market. Unlike the futures contract market, which is regulated by the CFTC and
by the regulations of the commodity exchanges, the forward contract market is
unregulated. The Portfolio will use forward contracts for the same hedging
purposes as those applicable to futures contracts, as described above. When the
Portfolio enters into a forward contract it will establish with the custodian a
segregated account consisting of cash, liquid assets or bullion equal to the
market value of the forward contract purchased.
 
    Precious metals futures and forward contract prices can be volatile and are
influenced principally by changes in spot market prices, which in turn are
affected by a variety of political and economic factors. In addition,
expectations of changing market conditions may at times influence the prices of
such futures and forward contracts, and changes in the cost of holding physical
precious metals, including storage, insurance and interest expense, will also
affect the relationship between spot and futures or forward prices. While the
correlation between changes in prices of futures and forward contracts and
prices of the precious metals being hedged by such contracts has historically
been very strong, the correlation may at times be imperfect and even a well
conceived hedge may be unsuccessful to some degree because of market behavior or
unexpected precious metals price trends. To the extent that interest rates move
in a direction opposite to that anticipated, the Portfolio may realize a loss on
a futures transaction not offset by an increase in the value of portfolio
securities. Moreover there is a possibility of a lack of a liquid secondary
market for closing out a futures position or futures option. The success of any
hedging technique depends upon the Adviser's and Sub-Adviser's accuracy in
predicting the direction of a market. If these predictions are incorrect, the
Portfolio may realize a loss.
 
    The Portfolio may also purchase (buy) and write (sell) covered call or put
options on precious metals futures contracts. Such options would be purchased
solely for hedging purposes similar to those applicable to the purchase and sale
of futures contracts. Call options might be purchased to hedge against an
increase in the price of precious metals the Portfolio intends to
 
                                                                          15
<PAGE>
acquire, and put options may be purchased to hedge against a decline in the
price of precious metals owned by the Portfolio. As is the case with futures
contracts, options on precious metals futures may facilitate the Portfolio's
acquisition of precious metals or permit the Portfolio to defer disposition of
precious metals for tax or other purposes. The Portfolio may not purchase
options on precious metals and precious metals futures contracts if the premiums
paid for all such options, together with margin deposits on precious metals
future contracts, would exceed 5% of the Portfolio's total assets at the time
the option is purchased.
 
    One of the risks which may arise in employing futures contracts to protect
against the price volatility of the Portfolio's assets is that the price of
precious metals subject to futures contracts (and thereby the futures contracts
prices) may correlate imperfectly with the prices of such assets. A correlation
may also be distorted by the fact that the futures market is dominated by
short-term traders seeking to profit from the difference between a contract or
security price objective and their cost of borrowed funds. Such distortions are
generally minor and would diminish as the contract approached maturity.
 
SECURITIES LENDING
 
    A Portfolio may lend its investment securities to qualified institutional
investors who need to borrow securities in order to complete certain
transactions, such as covering short sales, avoiding failures to deliver
securities or completing arbitrage operations. By lending its investment
securities, a Portfolio attempts to increase its net investment income through
the receipt of interest on the loan. Any gain or loss in the market price of the
securities loaned that might occur during the term of the loan would be for the
account of the Portfolio. A Portfolio may lend its investment securities to
qualified brokers, dealers, domestic and foreign banks or other financial
institutions, so long as the terms, structure and the aggregate amount of such
loans are not inconsistent with the 1940 Act, or the Rules and Regulations or
interpretations of the Commission thereunder, which currently require that (i)
the borrower pledge and maintain with the portfolio collateral consisting of
cash, an irrevocable letter of credit issued by a domestic U.S. bank, or
securities issued or guaranteed by the U.S. Government having a value at all
times not less than 100% of the value of the securities loaned; (ii) the
borrower add to such collateral whenever the price of the securities loaned
rises (i.e., the borrower "marks to the market" on a daily basis); (iii) the
loan be made subject to termination by the Portfolio at any time; and (iv) the
Portfolio receive reasonable interest on the loan (which may include the
Portfolio investing any cash collateral in interest bearing short-term
investments), any distributions on the loaned securities and any increase in
their market value. There may be risks of delay in recovery of the securities or
even loss of rights in the collateral should the borrower of the securities fail
financially. However, loans will only be made to borrowers deemed by the Adviser
or Sub-Adviser to be of good standing and when, in the judgment of the Adviser
or Sub-Adviser, the consideration which can be earned currently from such
securities loans justifies the attendant risk. All relevant facts and
circumstances, including the creditworthiness of the broker, dealer or
institution, will be considered in making decisions with respect to the lending
of securities, subject to review by the Board of Directors of the Fund.
 
    At the present time, the staff of the Commission does not object if an
investment company pays reasonable negotiated fees in connection with loaned
securities, so long as such fees are set forth in a written contract and
approved by the investment company's Board of Directors. In addition, voting
rights may pass with the loaned securities, but if a material event will occur
affecting an investment on loan, the loan must be called and the securities
voted.
 
SHORT SALES
 
    Certain Portfolios may from time to time sell securities short without
limitation but consistent with applicable legal requirements. A short sale is a
transaction in which the Portfolio sells securities it owns or has the right to
acquire at no added cost (i.e., "against the box") or does not own (but has
borrowed) in anticipation of a decline in the market price of the securities.
When the Portfolio makes a short sale of borrowed securities, the proceeds it
receives from the sale will be held on behalf of a broker until the Portfolio
replaces the borrowed securities. To deliver the securities to the buyer, the
Portfolio will need to arrange through a broker to borrow the securities and, in
so doing, the Portfolio will become obligated to replace the securities borrowed
at their market price at the time of replacement, whatever that price may be.
The Portfolio may have to pay a premium to borrow the securities and must pay
any dividends or interest payable on the securities until they are replaced.
 
    The Portfolio's obligation to replace the securities borrowed in connection
with a short sale will be secured by collateral deposited with the broker that
consists of cash or liquid securities. In addition, if the short sale is not
"against the box," the Portfolio will place in a segregated account with its
custodian, or designated sub-custodian, an amount of cash or liquid securities
equal to the difference, if any, between the market value of the securities sold
short and any cash or liquid securities deposited as collateral with the broker
in connection with the short sale. Until it replaces the borrowed securities,
the Portfolio will maintain the segregated account daily at a level so that the
amount deposited in the account plus the amount deposited with the broker will
equal the current market value of the securities sold short.
 
    Short sales by the Portfolio involve certain risks and special
considerations. Possible losses from short sales differ from losses that could
be incurred from a purchase of a security, because losses from short sales may
be unlimited, whereas losses from purchases can equal only the total amount
invested.
 
    16
<PAGE>
U.S. GOVERNMENT SECURITIES
 
    The term "U.S. Government securities" refers to a variety of securities
which are issued or guaranteed by the U.S. Government, and by various
instrumentalities which have been established or sponsored by the U.S.
Government.
 
    U.S. Treasury securities are backed by the "full faith and credit" of the
United States. Securities issued or guaranteed by Federal agencies and U.S.
Government sponsored instrumentalities may or may not be backed by the full
faith and credit of the United States. In the case of securities not backed by
the full faith and credit of the United States, an investor must look
principally to the agency or instrumentality issuing or guaranteeing the
obligation for ultimate repayment, and may not be able to assert a claim against
the United States itself in the event the agency or instrumentality does not
meet its commitment. Agencies which are backed by the full faith and credit of
the United States include the Export-Import Bank, Farmers Home Administration,
Federal Financing Bank, and others. Certain agencies and instrumentalities, such
as the GNMA, are, in effect, backed by the full faith and credit of the United
States through provisions in their charters that they may make "indefinite and
unlimited" drawings on the Treasury if needed to service debt. Debt from certain
other agencies and instrumentalities, including the Federal Home Loan Bank and
Fannie Mae, are not guaranteed by the United States, but those institutions are
protected by the discretionary authority for the U.S. Treasury to purchase
certain amounts of their securities to assist the institution in meeting its
debt obligations. However, the U.S. Treasury has no lawful obligation to assume
the financial liabilities of these agencies or others. Finally, other agencies
and instrumentalities, such as the Farm Credit System and the FHLMC, are
federally chartered institutions under Government supervision, but their debt
securities are backed only by the creditworthiness of those institutions, not
the U.S. Government.
 
    Some of the U.S. Government agencies that issue or guarantee securities
include the Export-Import Bank of the United States, Farmers Home
Administration, Federal Housing Administration, Maritime Administration, Small
Business Administration, and the Tennessee Valley Authority.
 
    An instrumentality of the U.S. Government is a Government agency organized
under Federal charter with Government supervision. Instrumentalities issuing or
guaranteeing securities include, among others, Federal Home Loan Banks, the
Federal Land Banks, Central Bank for Cooperatives, Federal Immediate Credit
Banks, and Fannie Mae.
 
                                     TAXES
 
    The following is only a summary of certain additional federal income tax
considerations generally affecting the Fund and its shareholders that are not
described in the Prospectuses. No attempt is made to present a detailed
explanation of the federal, state or local tax treatment of the Fund or its
shareholders, and the discussion here and in the Fund's Prospectuses is not
intended as a substitute for careful tax planning.
 
    The following discussion of federal income tax consequences is based on the
Internal Revenue Code of 1986, as amended (the "Code") and the regulations
issued thereunder as in effect on the date of this Statement of Additional
Information. New legislation, as well as administrative changes or court
decisions, may significantly change the conclusions expressed herein, and may
have a retroactive effect with respect to the transactions contemplated herein.
 
    Each Portfolio within the Fund is generally treated as a separate
corporation for federal income tax purposes, and thus the provisions of the Code
generally will be applied to each Portfolio separately, rather than to the Fund
as a whole.
 
              GENERAL REGULATED INVESTMENT COMPANY QUALIFICATIONS
 
    Each Portfolio intends to qualify and elect to be treated for each taxable
year as a regulated investment company ("RIC") under Subchapter M of the Code.
Accordingly, each Portfolio must, among other things, (a) derive at least 90% of
its gross income each taxable year from dividends, interest, payments with
respect to securities loans, gains from the sale or other disposition of stock,
securities or foreign currencies, and certain other related income, including,
generally, certain gains from options, futures and forward contracts; and (b)
diversify its holdings so that, at the end of each fiscal quarter of the
Portfolio's taxable year, (i) at least 50% of the market value of the
Portfolio's total assets is represented by cash and cash items, United States
Government securities, securities of other RICs, and other securities, with such
other securities limited, in respect to any one issuer, to an amount not greater
than 5% of the value of the Portfolio's total assets or 10% of the outstanding
voting securities of such issuer, and (ii) not more than 25% of the value of its
total assets is invested in the securities (other than United States Government
securities or securities of other RICs) of any one issuer or two or more issuers
which the Portfolio controls and which are engaged in the same, similar, or
related trades or business. For purposes of the 90% of gross income requirement
described above, foreign currency gains which are not directly related to a
Portfolio's principal business of investing in stock or securities (or options
or futures with respect to stock or securities) may be excluded from income that
qualifies under the 90% requirement.
 
    In addition to the requirements described above, in order to qualify as a
RIC, a Portfolio must distribute at least 90% of its net investment income
(which generally includes dividends, taxable interest, and the excess of net
short-term capital gains over net long-term capital losses less operating
expenses) and at least 90% of its net tax-exempt interest income, for each tax
year, if any, to its shareholders. If a Portfolio meets all of the RIC
requirements, it will not be subject to federal income tax on any of its net
investment income or capital gains that it distributes to shareholders.
 
                                                                          17
<PAGE>
    If a Portfolio fails to qualify as a RIC for any year, all of its income
will be subject to tax at corporate rates, and its distributions (including
capital gains distributions) will be taxable as ordinary income dividends to its
shareholders to the extent of the Portfolio's current and accumulated earnings
and profits, and will be eligible for the corporate dividends received deduction
for corporate shareholders.
 
           GENERAL TAX TREATMENT OF QUALIFYING RICS AND SHAREHOLDERS
 
    Each Portfolio will decide whether to distribute or to retain all or part of
any net capital gains (the excess of net long-term capital gains over net
short-term capital losses) in any year for reinvestment. If any such gains are
retained, the Portfolio will pay federal income tax thereon, and, if the
Portfolio makes an election, the shareholders will include such undistributed
gains in their income, will increase their basis in Portfolio shares by 65% of
the amount included in their income and will be able to claim their share of the
tax paid by the Portfolio as a refundable credit.
 
    A gain or loss realized by a shareholder on the sale, exchange or redemption
of shares of a Portfolio held as a capital asset will be capital gain or loss,
and such gain or loss will be long-term if the holding period for the shares
exceeds 18 months, will be mid-term if the holding period exceeds 12 months, but
does not exceed 18 months, and otherwise will be short-term. Any loss realized
on a sale, exchange or redemption of shares of a Portfolio will be disallowed to
the extent the shares disposed of are replaced within the 61-day period
beginning 30 days before and ending 30 days after the shares are disposed of.
Any loss realized by a shareholder on the disposition of shares held 6 months or
less is treated as a long-term capital loss to the extent of any distributions
of net long-term capital gains received by the shareholder with respect to such
shares or any inclusion of undistributed capital gain with respect to such
shares.
 
    The conversion of Class A shares to Class B shares should not be a taxable
event to the shareholder.
 
    Each Portfolio will generally be subject to a nondeductible 4% federal
excise tax to the extent it fails to distribute by the end of any calendar year
at least 98% of its ordinary income for that year and 98% of its capital gain
net income (the excess of short- and long-term capital gains over short- and
long-term capital losses) for the one-year period ending on October 31 of that
year, plus certain other amounts.
 
    Each Portfolio is required by federal law to withhold 31% of reportable
payments (which may include dividends, capital gains distributions, and
redemptions) paid to shareholders who have not certified on the Account
Registration Form or on a separate form supplied by the Portfolio, that the
Social Security or Taxpayer Identification Number provided is correct and that
the shareholder is exempt from backup withholding or is not currently subject to
backup withholding.
 
    A Section 1256 position held by a Portfolio will generally be
marked-to-market (i.e. treated as if it were sold for fair market value) on the
last business day of a Fund's fiscal year, and all gain or loss associated with
fiscal year transactions and mark-to-market positions at fiscal year end (except
certain currency gain or loss covered by Section 988 of the Code) will generally
be treated as 60% long-term capital gain or loss and 40% short-term capital gain
or loss. The effect of Section 1256 mark-to-market rules may be to accelerate
income or to convert what otherwise would have been long-term capital gains into
short-term capital gains or short-term capital losses into long-term capital
losses within a Portfolio. The acceleration of income on Section 1256 positions
may require a Portfolio to accrue taxable income without the corresponding
receipt of cash. In order to generate cash to satisfy the distribution
requirements of the Code, a Portfolio may be required to dispose of portfolio
securities that they otherwise would have continued to hold or to use cash flows
from other sources such as the sale of Portfolio shares. In these ways, any or
all of these rules may affect the amount, character and timing of income earned
and in turn distributed to shareholders by a Portfolio.
 
    As discussed above, in order for each Portfolio to continue to qualify for
federal income tax treatment as a RIC, at least 90% of its gross income for a
taxable year must be derived from certain qualifying income, including
dividends, interest, income derived from loans of securities, and gains from the
sale or other disposition of stock, securities or foreign currencies, or other
related income, including gains from options, futures and forward contracts,
derived with respect to its business of investing in stock, securities or
currencies. Any net gain realized from the closing out of futures contracts will
therefore generally be qualifying income for purposes of the 90% requirement.
 
    SPECIAL RULES FOR CERTAIN FOREIGN CURRENCY TRANSACTIONS.  In general, gains
from foreign currencies and from foreign currency options, foreign currency
futures and forward foreign exchange contracts relating to investments in stock,
securities or foreign currencies are currently considered to be qualifying
income for purposes of determining whether the Portfolio qualifies as a
regulated investment company. It is currently unclear, however, who will be
treated as the issuer of certain foreign currency instruments or how foreign
currency options, futures, or forward foreign currency contracts will be valued
for purposes of the regulated investment company diversification requirements
applicable to the Portfolio. The Portfolio may request a private letter ruling
from the Internal Revenue Service on some or all of these issues.
 
    Under Code Section 988, special rules are provided for certain transactions
in a foreign currency other than the taxpayer's functional currency (i.e.,
unless certain special rules apply, currencies other than the U.S. dollar). In
general, foreign currency gains or losses from forward contracts, from futures
contracts that are not "regulated futures contracts", and from unlisted options
will be treated as ordinary income or loss under Code Section 988. Also, certain
foreign exchange gains or losses derived with respect to foreign fixed-income
securities are also subject to Section 988 treatment. In general, therefore,
Code Section 988 gains or losses will increase or decrease the amount of the
Portfolio's investment company taxable income
 
    18
<PAGE>
available to be distributed to shareholders as ordinary income, rather than
increasing or decreasing the amount of the Portfolio's net capital gain.
 
    If the Portfolio invests in an entity which is classified as a "passive
foreign investment company" ("PFIC") for U.S. tax purposes, the application of
certain technical tax provisions applying to such companies could result in the
imposition of federal income tax with respect to such investments at the
Portfolio level which could not be eliminated by distributions to shareholders.
The U.S. Treasury issued proposed regulation section 1.1291-8 which establishes
a mark-to-market regime which allows investment companies investing in PFIC's to
avoid most, if not all, of the difficulties posed by the PFIC rules. The mark to
market regime was codified by the Taxpayer Relief Act of 1997. In any event, it
is not anticipated that any taxes on the Portfolio with respect to investments
in PFIC's would be significant.
 
    A Portfolio's investment in options, swaps and related transactions, futures
contracts and forward contracts, options on futures contracts and stock indices
and certain other securities, including transactions involving actual or deemed
short sales or foreign exchange gains or losses are subject to many complex and
special tax rules. For example, over-the-counter options on debt securities and
equity options, including options on stock and on narrow-based stock indexes,
will be subject to tax under Section 1234 of the Code, generally producing a
long-term or short-term capital gain or loss upon exercise, lapse or closing out
of the option or sale of the underlying stock or security. By contrast, a
Portfolio's treatment of certain other options, futures and forward contracts
entered into by a Portfolio is generally governed by Section 1256 of the Code.
These "Section 1256" positions generally include listed options on debt
securities, options on broad-based stock indexes, options on securities indexes,
options on futures contracts, regulated futures contracts and certain foreign
currency contracts and options thereon.
 
    When a Portfolio holds options or contracts which substantially diminish
their risk of loss with respect to other positions (as might occur in some
hedging transactions), this combination of positions could be treated as a
"straddle" for tax purposes, resulting in possible deferral of losses,
adjustments in the holding periods of Portfolio securities and conversion of
short-term capital losses into long-term capital losses. Certain tax elections
exist for mixed straddles i.e., straddles comprised of at least one Section 1256
position and at least one non-Section 1256 position which may reduce or
eliminate the operation of these straddle rules.
 
           SPECIAL TAX CONSIDERATIONS RELATING TO MUNICIPAL BOND AND
                       MUNICIPAL MONEY MARKET PORTFOLIOS
 
    Each of the Municipal Bond Portfolio and the Municipal Money Market
Portfolio will qualify to pay "exempt interest dividends" to its shareholders
provided that, at the close of each quarter of its taxable year at least 50% of
the value of its total assets consists of obligations the interest on which is
exempt from federal income tax. Current federal tax law limits the types and
volume of bonds qualifying for federal income tax exemption of interest, which
may have an effect on the ability of these Portfolios to purchase sufficient
amounts of tax-exempt securities to satisfy this requirement. Any loss on the
sale or exchange of shares of the Municipal Bond Portfolio or the Municipal
Money Market Portfolio held for six months or less will be disallowed to the
extent of any exempt-interest dividends received by the selling shareholder with
respect to such shares.
 
    As noted in the Prospectus for the Municipal Bond Portfolio and the
Municipal Money Market Portfolio, exempt-interest dividends are excludable from
a shareholder's gross income for regular Federal income tax purposes.
Exempt-interest dividends may nevertheless be subject to the alternative minimum
tax (the "Alternative Minimum Tax") imposed by Section 55 of the Code or the
environmental tax (the "Environmental Tax") imposed by Section 59A of the Code.
The Alternative Minimum Tax is imposed at the rate of up to 28% in the case of
non-corporate taxpayers and at the rate of 20% in the case of corporate
taxpayers, to the extent it exceeds the taxpayer's regular tax liability. The
Environmental Tax is imposed at the rate of 0.12% and applies only to corporate
taxpayers. The Alternative Minimum Tax and the Environmental Tax may be affected
by the receipt of exempt-interest dividends in two circumstances. First,
exempt-interest dividends derived from certain "private activity bonds" issued
after August 7, 1986, will generally be an item of tax preference and therefore
potentially subject to the Alternative Minimum Tax and the Environmental Tax.
The Portfolios intend, when possible, to avoid investing in private activity
bonds. Second, in the case of exempt-interest dividends received by corporate
shareholders, all exempt-interest dividends, regardless of when the bonds from
which they are derived were issued or whether they are derived from private
activity bonds, will be included in the corporation's "adjusted current
earnings," as defined in Section 56(g) of the Code, in calculating the
corporation's alternative minimum taxable income for purposes of determining the
Alternative Minimum Tax and the Environmental Tax.
 
    The percentage of income that constitutes "exempt-interest dividends" will
be determined for each year for the Municipal Bond Portfolio and the Municipal
Money Market Portfolio and will be applied uniformly to all dividends declared
with respect to the Portfolios during that year. This percentage may differ from
the actual percentage for any particular day.
 
    Interest on indebtedness incurred or continued by shareholders to purchase
or carry shares of the Municipal Bond Portfolio or the Municipal Money Market
Portfolio will not be deductible for federal income tax purposes. The deduction
otherwise allowable to property and casualty insurance companies for "losses
incurred" will be reduced by an amount equal to a portion of exempt-interest
dividends received or accrued during any taxable year. Foreign corporations
engaged in a trade or business in the United States will be subject to a "branch
profits tax" on their "dividend equivalent amount" for the taxable year, which
will include exempt-interest dividends. Certain Subchapter S corporations may
also be subject to taxes on their "passive investment income," which could
include exempt-interest dividends. Up to 85% of the Social Security benefits or
railroad retirement benefits received by an individual during any taxable year
will be included in the gross income of such
 
                                                                          19
<PAGE>
individual if the individual's "modified adjusted gross income" (which includes
exempt-interest dividends) plus one-half of the Social Security benefits or
railroad retirement benefits received by such individual during that taxable
year exceeds the base amount described in Section 86 of the Code.
 
    Entities or persons who are "substantial users" (or persons related to
"substantial users") of facilities financed by industrial development bonds or
private activity bonds should consult their tax advisors before purchasing
shares of the Municipal Bond Portfolio or the Municipal Money Market Portfolio.
"Substantial user" is defined generally for these purposes as including a
"non-exempt person" who regularly uses in trade or business a part of a facility
financed from the proceeds of such bonds.
 
    Issuers of bonds purchased by the Municipal Bond Portfolio (or the
beneficiary of such bonds) may have made certain representations or covenants in
connection with the issuance of such bonds to satisfy certain requirements of
the Code that must be satisfied subsequent to the issuance of such bonds.
Investors should be aware that exempt-interest dividends derived from such bonds
may become subject to federal income taxation retroactively to the date thereof
if such representations are determined to have been inaccurate or if the issuer
of such bonds (or the beneficiary of such bonds) fails to comply with such
covenants.
 
    The state and local tax consequences of an investment in either the
Municipal Bond or Municipal Money Market Portfolios may differ from the federal
consequences described above and shareholders are urged to consult their tax
advisers with respect to such aspects.
 
           SPECIAL TAX CONSIDERATIONS RELATING TO FOREIGN INVESTMENTS
 
    Gains or losses attributable to foreign currency contracts, or to
fluctuations in exchange rates that occur between the time a Portfolio accrues
interest or other receivables or accrues expenses or other liabilities
denominated in a foreign currency and the time the Portfolio actually collects
such receivables or pays such liabilities are treated as ordinary income or
ordinary loss to the Portfolio. Similarly, gains or losses on disposition of
debt securities denominated in a foreign currency attributable to fluctuations
in the value of the foreign currency between the date of acquisition of the
security and the date of disposition also are treated as ordinary gain or loss
to the Portfolio. These gains or losses increase or decrease the amount of a
Portfolio's net investment income available to be distributed to its
shareholders as ordinary income.
 
    It is expected that each Portfolio will be subject to foreign withholding
taxes with respect to its dividend and interest income from foreign countries,
and a Portfolio may be subject to foreign income taxes with respect to other
income. So long as more than 50% in value of a Portfolio's total assets at the
close of the taxable year consists of stock or securities of foreign
corporations, the Portfolio may elect to treat certain foreign income taxes
imposed on it for U.S. federal income tax purposes as paid directly by its
shareholders. A Portfolio will make such an election only if it deems it to be
in the best interest of its shareholders and will notify shareholders in writing
each year if it makes an election and of the amount of foreign income taxes, if
any, to be treated as paid by the shareholders. If a Portfolio makes the
election, shareholders will be required to include in income their proportionate
shares of the amount of foreign income taxes treated as imposed on the Portfolio
and will be entitled to claim either a credit (subject to the limitations
discussed below) or, if they itemize deductions, a deduction, for their shares
of the foreign income taxes in computing their federal income tax liability.
 
    Certain foreign governments levy withholding or other taxes on dividend and
interest income. Although in some countries a portion of these taxes are
recoverable, the non-recovered portion of foreign withholding taxes will reduce
the income received from investments in such countries. Except in the case of
the International Equity, Global Equity, European Equity, Japanese Equity, Asian
Equity, Global Fixed Income, International Fixed Income, International Magnum,
International Small Cap, Latin American and China Growth Portfolios, it is not
expected that a Portfolio or its shareholders would be able to claim a credit
for U.S. tax purposes with respect to any such foreign taxes. However, these
foreign withholding taxes may not have a significant impact on such Portfolios,
because each Portfolio's investment objective is to seek long-term capital
appreciation and any dividend or interest income should be considered
incidental.
 
    Shareholders who choose to utilize a credit (rather than a deduction) for
foreign taxes will be subject to a number of complex limitations regarding the
availability and utilization of the credit. Because of these limitations,
shareholders may be unable to claim a credit for the full amount of their
proportionate shares of the foreign income taxes paid by a Portfolio.
Shareholders are urged to consult their tax advisors regarding the application
of these rules to their particular circumstances.
 
                         TAXES AND FOREIGN SHAREHOLDERS
 
    Taxation of a shareholder who, as to the United States, is a nonresident
alien individual, a foreign trust or estate, a foreign corporation, or a foreign
partnership ("Foreign Shareholder") depends on whether the income from the
Portfolio is "effectively connected" with a U.S. trade or business carried on by
such shareholder.
 
    If the income from the Portfolio is not effectively connected with a U.S.
trade or business carried on by a Foreign Shareholder, distributions of net
investment income plus the excess of net short-term capital gains over net
long-term capital losses will be subject to U.S. withholding tax at the rate of
30% (or such lower treaty rate as may be applicable) upon the gross amount of
the dividend. Furthermore, Foreign Shareholders will generally be exempt from
U.S. federal income tax on gains realized on the sale of shares of the
Portfolio, distributions of net long-term capital gains, and amounts retained by
the Fund which are designated as undistributed capital gains.
 
    20
<PAGE>
    If the income from the Portfolio is effectively connected with a U.S. trade
or business carried on by a Foreign Shareholder, then distributions from the
Portfolio and any gains realized upon the sale of shares of the Portfolio, will
be subject to U.S. federal income tax at the rates applicable to U.S. citizens
and residents or domestic corporations.
 
    The Portfolio may be required to withhold U.S. federal income tax on
distributions that are otherwise exempt from withholding tax (or taxable at a
reduced treaty rate) unless the Foreign Shareholder complies with Internal
Revenue Service certification requirements.
 
    The tax consequences to a Foreign Shareholder entitled to claim the benefits
of an applicable tax treaty may differ from those described here. Furthermore,
Foreign Shareholders are strongly urged to consult their own tax advisors with
respect to the particular tax consequences to them of an investment in a
Portfolio, including the potential application of the provisions of the Foreign
Investment in Real Estate Property Tax Act of 1980, as amended.
 
                               PURCHASE OF SHARES
 
    Shares of the Fund may be purchased on any day the New York Stock Exchange
(the "NYSE") is open. The NYSE will be closed on the following days: New Year's
Day, Martin Luther King, Jr. Day, Presidents' Day, Good Friday, Memorial Day,
Independence Day, Labor Day, Thanksgiving Day and Christmas Day. Each Portfolio
reserves the right in its sole discretion (i) to suspend the offering of its
shares, (ii) to reject purchase orders when in the judgment of management such
rejection is in the best interest of the Fund, and (iii) to reduce or waive the
minimum for initial and subsequent investments for certain accounts such as
employee benefit plans or under circumstances where certain economies can be
achieved in sales of a Portfolio's shares. The International Equity, Emerging
Markets, Small Cap Value Equity, Gold and Balanced Portfolios are currently
closed to new investors with the exception of certain Morgan Stanley customers,
employees of Morgan Stanley, certain tax-qualified retirement plans and other
investment companies advised by Morgan Stanley Asset Management Inc. and its
affiliates.
 
                              REDEMPTION OF SHARES
 
    Each Portfolio may suspend redemption privileges or postpone the date of
payment (i) during any period that the NYSE is closed, or trading on the NYSE is
restricted as determined by the Commission; (ii) during any period when an
emergency exists as defined by the rules of the Commission as a result of which
it is not reasonably practicable for a Portfolio to dispose of securities owned
by it, or fairly to determine the value of its assets; and (iii) for such other
periods as the Commission may permit.
 
    No charge is made by any Portfolio for redemptions except for the 1%
transaction fee that may be assessed upon redemption of the International Small
Cap Portfolio. Any redemption may be more or less than the shareholder's cost
depending on the market value of the securities held by the Portfolio.
 
    To protect your account and the Fund from fraud, signature guarantees are
required for certain redemptions. Signature guarantees enable the Fund to verify
the identity of the person who has authorized a redemption from your account.
Signature guarantees are required in connection with: (i) all redemptions,
regardless of the amount involved, when the proceeds are to be paid to someone
other than the registered owner(s) and/or registered address; and (ii) share
transfer requests. An "eligible guarantor institution" guarantor may include a
bank, a trust company, a credit union or savings and loan association, a member
firm of a domestic stock exchange, or a foreign branch of any of the foregoing.
Notaries public are not acceptable guarantors. The signature guarantees must
appear either: (i) on the written request for redemption; (ii) on a separate
instrument for assignment ("stock power") which should specify the total number
of shares to be redeemed; or (iii) on all stock certificates tendered for
redemption and, if shares held by the Fund are also being redeemed, on the
letter or stock power.
 
    The Fund has made an election with the Commission pursuant to Rule 18f-1
under the 1940 Act to pay in cash all redemptions requested by any shareholder
of record limited in amount during any 90-day period to the lesser of $250,000
or 1% of the net assets of a Portfolio at the beginning of such period. Such
commitment is irrevocable without the prior approval of the Commission.
Redemptions in excess of the above limits may be paid in whole or in part in
investment securities or in cash, as the Board of Directors may deem advisable
as being in the best interests of the Fund. If redemptions are paid in
investment securities, such securities will be valued as set forth in the Fund's
Prospectus under "Valuation of Shares". A redeeming shareholder would normally
incur brokerage expenses in converting these securities to cash.
 
                              SHAREHOLDER SERVICES
 
EXCHANGE FEATURES
 
    Shares of each Portfolio of the Fund may be exchanged for shares of any
other available Portfolio (other than the International Equity, Emerging
Markets, Small Cap Value Equity and Balanced Portfolios, which are closed to new
investors). Any such exchange will be based on the respective net asset values
of the shares involved. There is no sales commission or sales charge of any
kind. Before making an exchange, a shareholder should consider the investment
objectives of the Portfolio to be purchased.
 
                                                                          21
<PAGE>
    Exchange requests may be made either by mail or telephone. Exchange requests
by mail should be sent to Morgan Stanley Institutional Fund, Inc., P.O. Box
2798, Boston, Massachusetts 02208-2798. Telephone exchanges will be accepted
only if the certificates for the shares to be exchanged are held by the Fund for
the account of the shareholder and the registration of the two accounts will be
identical. Exchanges may be subject to limitations as to amounts or frequency,
and to other restrictions established by the Board of Directors to assure that
such exchanges do not disadvantage the Fund and its shareholders.
 
TRANSFER OF SHARES
 
    Shareholders may transfer shares of the Fund's Portfolios to another person
by making a written request to the Fund. The request should clearly identify the
account and number of shares to be transferred, and include the signature of all
registered owners and all stock certificates, if any, which are subject to the
transfer. The signature on the letter of request, the stock certificate or any
stock power must be guaranteed in the same manner as described under "Redemption
of Shares". As in the case of redemptions, the written request must be received
in good order before any transfer can be made. Transferring shares may affect
the eligibility of an account for a given class of the Portfolio's shares and
may result in involuntary conversion or redemption of such shares.
 
                             INVESTMENT LIMITATIONS
 
    Each current Portfolio has adopted the following restrictions which are
fundamental policies and may not be changed without the approval of the lesser
of: (i) at least 67% of the voting securities of the Portfolio present at a
meeting if the holders of more than 50% of the outstanding voting securities of
the Portfolio are present or represented by proxy; or (ii) more than 50% of the
outstanding voting securities of the Portfolio. Each Portfolio of the Fund will
not:
 
     (1) purchase or sell physical commodities unless acquired as a result of
ownership of securities or other instruments (except this shall not prevent the
Portfolio from purchasing or selling options or futures contracts or from
investing in securities or other instruments backed by physical commodities),
and except that the Gold Portfolio may invest in gold bullion in accordance with
its investment objectives and policies;
 
     (2) purchase or sell real estate, although it may purchase and sell
securities of companies that deal in real estate and may purchase and sell
securities that are secured by interests in real estate;
 
     (3) lend any security or make any other loan if, as a result, more than
33 1/3% of its total assets would be lent to other parties, but this limitation
does not apply to purchases of debt securities or repurchase agreements;
 
     (4) except with respect to the Global Fixed Income, Emerging Markets,
Emerging Markets Debt, China Growth, Latin American, MicroCap, Aggressive
Equity, European Real Estate, Asian Real Estate, Technology and U.S. Real Estate
Portfolios (i) purchase more than 10% of any class of the outstanding voting
securities of any issuer and (ii) purchase securities of an issuer (except
obligations of the U.S. Government and its agencies and instrumentalities) if as
a result, with respect to 75% of its total assets, more than 5% of the
Portfolio's total assets, at market value, would be invested in the securities
of such issuer;
 
     (5) issue senior securities and will not borrow, except from banks and as a
temporary measure for extraordinary or emergency purposes and then, in no event,
in excess of 33 1/3% of its total assets (including the amount borrowed) less
liabilities (other than borrowings), except that each of the Emerging Markets
Debt and Latin American Portfolios may borrow from banks and other entities, and
the Technology Portfolio may borrow from banks, in an amount not in excess of
33 1/3% of its total assets (including the amount borrowed) less liabilities in
accordance with its investment objectives and policies;
 
     (6) underwrite securities issued by others, except to the extent that the
Portfolio may be considered an underwriter within the meaning of the 1933 Act in
the disposition of restricted securities;
 
     (7) acquire any securities of companies within one industry if, as a result
of such acquisition, more than 25% of the value of the Portfolio's total assets
would be invested in securities of companies within such industry; provided,
however, that there shall be no limitation on the purchase of obligations issued
or guaranteed by the U.S. Government, its agencies or instrumentalities, or (in
the case of the Money Market Portfolio or the Municipal Money Market Portfolio)
instruments issued by U.S. Banks, except that (i) the Latin American Portfolio
may invest more than 25% of its total assets in companies involved in the
telecommunications industry or financial services industry; (ii) the Gold
Portfolio will invest more than 25% of its total assets in securities of
companies in the group of industries involved in gold-related or
precious-metals-related activities, as described in its prospectus, and may
invest more than 25% of its total assets in one or more of the industries that
are a part of such group of industries, as described in its prospectus; (iii)
each of the Asian Real Estate, European Real Estate and U.S. Real Estate
Portfolios will invest more than 25% of its total assets in the Asian, European
and U.S. real estate industries, respectively, as described in their
prospectuses; and (iv) the Technology Portfolio will invest more than 25% of its
assets in securities of companies in the technology or technology-related
industries; and
 
     (8) write or acquire options or interests in oil, gas or other mineral
exploration or development programs.
 
    In addition, each current Portfolio of the Fund has adopted non-fundamental
investment limitations as stated below and in their respective Prospectuses.
Such limitations may be changed without shareholder approval. Each current
Portfolio of the Fund will not:
 
    22
<PAGE>
     (1) purchase on margin or sell short, except (i) that the Emerging Markets
Debt, Latin American, Aggressive Equity and Technology Portfolios may from time
to time sell securities short without limitation but consistent with applicable
legal requirements as stated in its Prospectus; (ii) that each Portfolio, except
the Money Market and Municipal Money Market Portfolios may enter into option
transactions and futures contracts as described in its Prospectus; and (iii) as
specified above in fundamental investment limitation number (1) above;
 
     (2) except for the High Yield Portfolio, purchase or retain securities of
an issuer if those officers and Directors of the Fund or its investment adviser
owning more than 1/2 of 1% of such securities together own more than 5% of such
securities;
 
     (3) pledge, mortgage, or hypothecate any of its assets to an extent greater
than 10% of its total assets at fairmarket value, except that the High Yield
Portfolio may pledge, mortgage or hypothecate a maximum of 50% of its assets,
not counting assets segregated to comply with coverage requirements under
Section 18(f) of the 1940 Act, and the SEC's rules, regulations, orders, and
interpretations thereunder;
 
     (4) invest for the purpose of exercising control over management of any
company;
 
     (5) invest its assets in securities of any investment company, except as
permitted by the 1940 Act or the rules, regulations, interpretations or orders
of the SEC and its staff thereunder;
 
     (6) except for the U.S. Real Estate, European Real Estate and Asian Real
Estate Portfolios, invest in real estate limited partnership interests, and the
U.S. Real Estate, European Real Estate and Asian Real Estate Portfolios may not
invest in such interests that are not publicly traded;
 
     (7) make loans except (i) by purchasing bonds, debentures or similar
obligations (including repurchase agreements, subject to the limitations as
described in the respective Prospectuses) that are publicly distributed, except
that the High Yield Portfolio also may purchase such securities that are not
publicly distributed; (ii) by lending its portfolio securities to banks,
brokers, dealers and other financial institutions so long as such loans are not
inconsistent with the 1940 Act or the Rules and Regulations or interpretations
of the Commission thereunder; and (iii) the High Yield Portfolio may lend
securities to institutional investors in addition to entities described in (ii);
 
     (8) borrow money, except from banks for extraordinary or emergency
purposes, and then only in amounts up to 10% of the value of the Portfolio's
total assets, or purchase securities while borrowings exceed 5% of its total
assets, except that (i) the Latin American, Emerging Markets Debt and Technology
Portfolios may borrow in accordance with fundamental investment limitation
number (5) above; and (ii) the High Yield Portfolio may borrow up to 33 1/3% of
its total assets in the aggregate, including reverse repurchase agreements; and
 
     (9) except for the High Yield Portfolio, invest in fixed time deposits with
a duration of over seven calendar days or invest in fixed time deposits with a
duration of from two business days to seven calendar days if more than 10% of
the Portfolio's total assets would be invested in these deposits.
 
    The Balanced, Fixed Income and Value Equity Portfolios will only issue
shares for securities or assets other than cash in a bona fide reorganization,
statutory merger, or in other acquisitions of portfolio securities (except for
municipal debt securities issued by state political subdivisions or their
agencies or instrumentalities) which (i) meet their respective investment
objectives; and (ii) are acquired for investment and not for resale.
 
    Each of the Global Fixed Income, Emerging Markets, Emerging Markets Debt,
China Growth, Latin American, Aggressive Equity, European Real Estate, Asian
Real Estate and U.S. Real Estate Portfolios will diversify its holdings so that,
at the close of each quarter of its taxable year, (i) at least 50% of the market
value of the Portfolio's total assets is represented by cash (including cash
items and receivables), U.S. Government securities, and other securities, with
such other securities limited, in respect of any one issuer, for purposes of
this calculation to an amount not greater than 5% of the value of the
Portfolio's total assets and 10% of the outstanding voting securities of such
issuer; and (ii) not more than 25% of the value of its total assets is invested
in the securities of any one issuer (other than U.S. Government securities).
 
    With respect to fundamental investment limitation number (7), the Fund will
determine industry concentration in accordance with the classifications of
industries based on the Industry Numbers from the Standard Industrial
Classification Manual as prepared by the Office of Management and Budget, except
that (i) with respect to the Money Market, Municipal Money Market and High Yield
Portfolios, (a) financial service companies will be classified according to the
end users of their services, for example, automobile finance, bank finance and
diversified finance will each be considered a separate industry and (b)
asset-backed securities will be classified according to the underlying assets
securing such securities; and (ii) with respect to the High Yield Portfolio,
utility companies will be classified according to their services, for example,
electric, gas, gas transmission, and telephone will be treated as separate
industries.
 
    In accordance with fundamental investment limitation number (7), the Latin
American Portfolio will only invest more than 25% of its total assets in
companies involved in the telecommunications industry or financial services
industry if the Board of Directors determines that the Latin American markets
are dominated by securities of issuers in such industries and that, in light of
the anticipated return, investment quality, availability and liquidity of the
issuers in such industries, the Portfolio's ability to achieve its investment
objective would, in light of the investment policies and limitations, be
materially adversely affected if the Portfolio was not able to invest greater
than 25% of its total assets in such industries. As stated in the
 
                                                                          23
<PAGE>
Prospectus, the Board of Directors has made the foregoing determination and,
accordingly, the Latin American Portfolio will invest between 25% and 40% of its
assets in securities of issuers engaged in the telecommunications industry.
 
    The percentage limitations contained in these restrictions apply at the time
of purchase of securities. Future Portfolios of the Fund may adopt different
limitations.
 
                 DETERMINING MATURITIES OF CERTAIN INSTRUMENTS
 
    Generally, the maturity of a portfolio instrument shall be deemed to be the
period remaining until the date noted on the face of the instrument as the date
on which the principal amount must be paid, or in the case of an instrument
called for redemption, the date on which the redemption payment must be made.
However, instruments having variable or floating interest rates or demand
features may be deemed to have remaining maturities as follows: (i) a Government
Obligation with a variable rate of interest readjusted no less frequently than
annually may be deemed to have a maturity equal to the period remaining until
the next readjustment of the interest rate; (ii) an instrument with a variable
rate of interest, the principal amount of which is scheduled on the face of the
instrument to be paid in one year or less, may be deemed to have a maturity
equal to the period remaining until the next readjustment of the interest rate;
(iii) an instrument with a variable rate of interest that is subject to a demand
feature may be deemed to have a maturity equal to the longer of the period
remaining until the next readjustment of the interest rate or the period
remaining until the principal amount can be recovered through demand; (iv) an
instrument with a floating rate of interest that is subject to a demand feature
may be deemed to have a maturity equal to the period remaining until the
principal amount can be recovered through demand; and (v) a repurchase agreement
may be deemed to have a maturity equal to the period remaining until the date on
which the repurchase of the underlying securities is scheduled to occur, or
where no date is specified, but the agreement is subject to demand, the notice
period applicable to a demand for the repurchase of the securities.
 
                             MANAGEMENT OF THE FUND
OFFICERS AND DIRECTORS
 
    The Fund's officers, under the supervision of the Board of Directors, manage
the day-to-day operations of the Fund. The Directors set broad policies for the
Fund and choose its officers. Two Directors and all of the officers of the Fund
are directors, officers or employees of the Adviser, Morgan Stanley or the
administrative services provider. Directors and officers of the Fund are also
directors and officers of some or all of the other investment companies managed,
administered, advised or distributed by the Adviser or its affiliates. The other
Directors have no affiliation with the Adviser, Morgan Stanley or the
administrative services provider. A list of the Directors and officers of the
Fund and a brief statement of their present positions and principal occupations
during the past five years is set forth below:
 
<TABLE>
<CAPTION>
NAME, ADDRESS AND DATE OF BIRTH            POSITION WITH FUND    PRINCIPAL OCCUPATION DURING PAST FIVE YEARS
- ---------------------------------------  ----------------------  --------------------------------------------------
<S>                                      <C>                     <C>
Barton M. Biggs*                         Chairman and Director   Chairman, Director and Managing Director of Morgan
 1221 Avenue of the Americas                                       Stanley Asset Management Inc. and Morgan Stanley
 New York, NY 10020                                                Asset Management Limited; Managing Director of
 11/26/32                                                          Morgan Stanley & Co. Incorporated; Director of
                                                                   Rand McNally Company; Member of the Yale
                                                                   Development Board; Chairman and Director of
                                                                   various U.S. registered investment companies
                                                                   managed by Morgan Stanley Asset Management Inc.
Michael F. Klein*                        Director and President  Principal of Morgan Stanley & Co. Incorporated and
 1221 Avenue of the Americas                                       Morgan Stanley Asset Management Inc; President
 New York, NY 10020                                                and Director of various U.S. registered
 12/12/58                                                          investment companies managed by Morgan Stanley
                                                                   Asset Management Inc.; Previously practiced law
                                                                   with the New York firm of Rogers & Wells.
John D. Barrett, II                      Director                Chairman and Director of Barrett Associates, Inc.
 521 Fifth Avenue                                                  (investment counseling); Director of the
 New York, NY 10135                                                Ashforth Company (real estate); Director of
 8/21/35                                                           Morgan Stanley Universal Funds, Inc. and Morgan
                                                                   Stanley Strategic Adviser Fund, Inc.
Gerard E. Jones                          Director                Partner in Richards & O'Neil LLP (law firm);
 43 Arch Street                                                    Director of Morgan Stanley Universal Funds, Inc.
 Greenwich, CT 06830                                               and Morgan Stanley Strategic Adviser Fund, Inc.
 1/23/37
</TABLE>
 
    24
<PAGE>
<TABLE>
<CAPTION>
NAME, ADDRESS AND DATE OF BIRTH            POSITION WITH FUND    PRINCIPAL OCCUPATION DURING PAST FIVE YEARS
- ---------------------------------------  ----------------------  --------------------------------------------------
<S>                                      <C>                     <C>
Andrew McNally IV                        Director                Director of Allendale Insurance Co., Mercury
 8255 North Central Park Avenue                                    Finance (consumer finance); Zenith Electronics,
 Skokie, IL 60076                                                  Hubbell, Inc. (industrial electronics); Director
 11/11/39                                                          of Morgan Stanley Universal Funds, Inc. and
                                                                   Morgan Stanley Strategic Adviser Fund, Inc.;
                                                                   Formerly, Chairman and Chief Executive Officer
                                                                   of Rand McNally & Company (publishing).
Samuel T. Reeves                         Director                Chairman of the Board and CEO, Pinacle L.L.C.
 8211 North Fresno Street                                          (investments); Director, Pacific Gas and
 Fresno, CA 93720                                                  Electric and PG&E Enterprises (utilities);
 7/28/34                                                           Director of Morgan Stanley Universal Funds, Inc.
                                                                   and Morgan Stanley Strategic Adviser Fund, Inc.
Fergus Reid                              Director                Chairman and Chief Executive Officer of LumeLite
 85 Charles Colman Blvd                                            Plastics Corporation (injection molding firm);
 Pawling, NY 12564                                                 Trustee and Director of Vista Mutual Fund Group;
 8/12/32                                                           Director of Morgan Stanley Universal Funds, Inc.
                                                                   and Morgan Stanley Strategic Adviser Fund, Inc.
Frederick O. Robertshaw                  Director                Of Counsel, Copple, Chamberlin Boehm, P.C.;
 2800 North Central Avenue                                         Formerly of Counsel, Bryan, Cave LLP; (law
 Phoenix, AZ 85004                                                 firms); Director of Morgan Stanley Universal
 1/24/34                                                           Funds, Inc. and Morgan Stanley Strategic Adviser
                                                                   Fund, Inc.
Harold J. Schaaff, Jr.*                  Vice President          Principal of Morgan Stanley & Co. Incorporated and
 1221 Avenue of the Americas                                       of Morgan Stanley Asset Management Inc.; General
 New York, NY 10020                                                Counsel and Secretary of Morgan Stanley Asset
 6/10/60                                                           Management Inc.; Vice President of various U.S.
                                                                   registered investment companies managed by
                                                                   Morgan Stanley Asset Management Inc.
Joseph P. Stadler*                       Vice President          Principal of Morgan Stanley & Co. Incorporated and
 1221 Avenue of the Americas                                       Morgan Stanley Asset Management Inc.; Previously
 New York, NY 10020                                                with Price Waterhouse LLP (accounting); Vice
 6/7/54                                                            President of various U.S. registered investment
                                                                   companies managed by Morgan Stanley Asset
                                                                   Management Inc.
Stefanie V. Chang*                       Vice President          Vice President of Morgan Stanley & Co.
 1221 Avenue of the Americas                                       Incorporated and Morgan Stanley Asset Management
 New York, NY 10020                                                Inc.; Vice President of various U.S. registered
 11/30/66                                                          investment companies managed by Morgan Stanley
                                                                   Asset Management Inc. Previously practiced law
                                                                   with the New York law firm of Rogers & Wells.
Valerie Y. Lewis*                        Secretary               Vice President of Morgan Stanley & Co.
 1221 Avenue of the Americas                                       Incorporated and Morgan Stanley Asset Management
 New York, NY 10020                                                Inc.; Previously with Citicorp (banking);
 3/26/56                                                           Secretary of various U.S. registered investment
                                                                   companies managed by Morgan Stanley Asset
                                                                   Management Inc.
Karl O. Hartmann                         Assistant Secretary     Senior Vice President, Secretary and General
 73 Tremont Street                                                 Counsel of Chase Global Funds Services Company;
 Boston, MA 02108-3913                                             Previously, President, Secretary and General
 3/7/55                                                            Counsel, Leland, O'Brien, Rubinstein Associates,
                                                                   Inc. (investments).
Joanna Haigney                           Treasurer               Assistant Vice President, Senior Manager of Fund
 73 Tremont Street                                                 Administration and Compliance Services, Chase
 Boston, MA 02108-3913                                             Global Funds Services Company; Treasurer of
 10/10/66                                                          various U.S. registered investment companies
                                                                   managed by Morgan Stanley Asset Management Inc.
                                                                   Previously with Coopers & Lybrand LLP.
Rene J. Feuerman                         Assistant Treasurer     Manager of Fund Administration and Compliance
 73 Tremont Street                                                 Services, Chase Global Funds Services Company.
 Boston, MA 02108-3913                                             Previously Fund Administrator and Senior Fund
 1/25/67                                                           Accountant, Chase Global Funds Services Company.
</TABLE>
 
- --------------
* "Interested Person" within the meaning of the 1940 Act.
 
                                                                          25
<PAGE>
REMUNERATION OF DIRECTORS AND OFFICERS
 
    Effective June 28, 1995, the Fund and other funds managed by MSAM (the "Fund
Complex") will pay each of the Directors who is not an "interested person" an
annual aggregate fee of $55,000, plus out-of-pocket expenses. The Fund Complex
will pay each of the members of the Fund's Audit Committee, which consists of
the Fund's Directors who are not "interested persons," an additional annual
aggregate fee of $10,000 for serving on such committee. The allocation of such
fees will be among the funds in the Fund Complex in proportion to their
respective average net assets. For the fiscal year ended December 31, 1997, the
Fund paid approximately $431,000 in Directors' fees and expenses. Directors who
are also officers or affiliated persons receive no remuneration for their
services as Directors. The Fund's officers and employees are paid by the Adviser
or its agents. As of March 31, 1998, to Fund management's knowledge, the
Directors and officers of the Fund, as a group, owned more than 1% of the
outstanding common stock of the following portfolio of the Fund: 2.2% Latin
American Portfolio--Class A Shares. The following table shows aggregate
compensation paid to each of the Fund's Directors by the Fund and the Fund
Complex, respectively, in the fiscal year ended December 31, 1997.
 
    The Fund maintains an unfunded Deferred Compensation Plan ("Plan") which
allows each independent Director to defer payment of all, or a portion, of the
fees he or she receives for attending meetings of the Board of Directors
throughout the year. Each eligible Director may elect to have the deferred
amounts credited with a return equal to either of the following: (i) a rate
equal to the prevailing rate for 90-day U.S. Treasury Bills, or (ii) a rate
equal to the total return on any portfolios of the Fund selected by the
Director. Distributions generally are in the form of equal annual installments
over a period of five (5) years beginning on the first day of the year following
the year in which the Director's service terminates, except that the Board of
Directors, in its sole discretion, may accelerate or extend such distribution
schedule. The Fund intends that the Plan shall be maintained at all times on an
unfunded basis for federal income tax purposes under the Code. The rights of an
eligible Director and the beneficiaries to the amounts held under the Plan are
unsecured and such amounts are subject to the claims of the creditors of the
Fund.
 
                               COMPENSATION TABLE
 
<TABLE>
<CAPTION>
                                                                                               (4)
                                                         (2)                (3)             ESTIMATED            (5)
                                                      AGGREGATE    PENSION OR RETIREMENT     ANNUAL      TOTAL COMPENSATION
                                                    COMPENSATION     BENEFITS ACCRUED       BENEFITS       FROM REGISTRANT
                       (1)                              FROM          AS PART OF FUND         UPON        AND FUND COMPLEX
             NAME OF PERSON, POSITION                REGISTRANT          EXPENSES          RETIREMENT     PAID TO DIRECTORS
- --------------------------------------------------  -------------  ---------------------  -------------  -------------------
<S>                                                 <C>            <C>                    <C>            <C>
Barton M. Biggs,
 Director and Chairman of the Board...............         None                N/A                N/A              None
Warren J. Olsen,*
 Director and President...........................         None                N/A                N/A              None
Michael F. Klein,**
 Director and President...........................         None                N/A                N/A              None
John D. Barrett, II
 Director.........................................       63,379                N/A                N/A            68,900
Gerard E. Jones,
 Director.........................................       63,379                N/A                N/A            86,000
Andrew McNally, IV+
 Director.........................................       65,930                N/A                N/A            71,100
Samuel T. Reeves,+
 Director.........................................       65,930                N/A                N/A            75,840
Fergus Reid,+
 Director.........................................       63,379                N/A                N/A            86,000
Frederick O. Robertshaw,
 Director.........................................       65,930                N/A                N/A            71,100
Frederick B. Whittemore,***
 Director.........................................         None                N/A                N/A              None
</TABLE>
 
- ------------------
*   As of May 31, 1997, Mr. Olsen resigned from the Board of Directors.
**  Mr. Klein was appointed to the Board of Directors effective May 31, 1997.
*** As of March 14, 1997, Mr. Whittemore resigned from the Board of Directors.
+   Messrs. McNally, Reeves and Reid elected, pursuant to the deferred
    compensation plan, to defer all of their compensation received from the Fund
    for the fiscal year ended December 31, 1997.
 
INVESTMENT ADVISORY AND ADMINISTRATIVE AGREEMENTS
 
    MSAM is a wholly-owned subsidiary of Morgan Stanley Dean Witter & Co. The
principal offices of Morgan Stanley Dean Witter & Co. are located at 1585
Broadway, New York, NY 10036, and the principal offices of MSAM are located at
1221 Avenue of the Americas, New York, NY 10020. As compensation for advisory
services for the fiscal years ended December 31,
 
    26
<PAGE>
1995, December 31, 1996 and December 31, 1997, the Adviser earned fees of
approximately $40,534,000, $55,465,000 and $72,445,000, respectively, and from
such fees voluntarily waived fees of $3,526,000, $4,340,000 and $3,818,000,
respectively. For the fiscal years ended December 31, 1995, December 31, 1996
and December 31, 1997, the Fund paid brokerage commissions of approximately
$10,317,515, $17,014,335 and $26,051,356, respectively. For the fiscal years
ended December 31, 1995, December 31, 1996 and December 31, 1997, the Fund paid
in the aggregate $377,000, $826,686 and $1,060,894, respectively, as brokerage
commissions to Morgan Stanley & Co. Incorporated ("Morgan Stanley" or the
"Distributor"), an affiliated broker-dealer, which represented 4%, 5% and 4.10%
of the total amount of brokerage commissions paid in each respective period. For
the fiscal year ended December 31, 1997, the Fund paid in the aggregate $1,988
as brokerage commissions to Dean Witter Reynolds, Inc., an affiliated
broker-dealer which represented 0.03% of the total amount of brokerage
commissions paid in the period. For the fiscal years ended December 31, 1995,
December 31, 1996 and December 31, 1997, the Fund paid administrative fees to
MSAM of approximately $5,238,000, $7,298,531 and $9,371,400, respectively.
 
    Sun Valley Gold Company (the "Sub-Adviser"), with principal offices at 620
Sun Valley Road, Sun Valley, Idaho, serves as the investment sub-adviser of the
Gold Portfolio, pursuant to a sub-advisory agreement among the Fund, the Adviser
and the Sub-Adviser (the "Sub-Advisory Agreement"). The Adviser and the
Sub-Adviser have entered into an indemnification agreement under which,
generally, the Sub-Adviser has agreed to indemnify the Adviser and the Fund for
claims or losses in connection with any failure by the Sub-Adviser to comply
with its obligations under the Sub-Advisory Agreement or related agreements or
any act or omission that amounts to negligence, misfeasance or bad faith, and
the Adviser has agreed to indemnify the Sub-Adviser for claims or losses in
connection with any failure by the Adviser to comply with its obligations under
the Sub-Advisory Agreement or related agreements. As compensation for
sub-advisory services for the fiscal years ended December 31, 1995, December 31,
1996 and December 31, 1997, the Sub-Adviser earned fees of approximately
$73,000, $110,000 and $106,000, respectively, and from such fees voluntarily
waived fees of $37,000, $52,000 and $46,000, respectively. For the fiscal years
ended December 31, 1995, December 31, 1996 and December 31, 1997, the Fund paid
$450, $0 and $0, respectively, as brokerage commissions to Sun Valley Gold
Trading, Inc., a broker-dealer affiliated with the Sub-Adviser.
 
    Pursuant to the MSAM Administration Agreement between the Adviser and the
Fund, the Adviser provides Administrative Services. For its services under the
Administration Agreement, the Fund pays the Adviser a monthly fee which on an
annual basis equals 0.15 of 1% of the average daily net assets of each
Portfolio.
 
    Under the Agreement between the Adviser and The Chase Manhattan Bank
("Chase"), Chase Global Funds Services Company ("CGFSC," a corporate affiliate
of Chase) provides certain administrative services to the Fund. CGFSC provides
operational and administrative services to investment companies with
approximately $161 billion in assets and having approximately 216,918
shareholder accounts as of March 31, 1998. CGFSC's business address is 73
Tremont Street, Boston, Massachusetts 02108-3913.
 
DISTRIBUTION OF FUND SHARES
 
    The Distributor, a wholly-owned subsidiary of Morgan Stanley, Dean Witter,
Discover & Co., serves as the Distributor of the Fund's shares pursuant to a
Distribution Agreement for the Fund and a Plan of Distribution for the Class B
shares of the Portfolios (except the Municipal Money Market and International
Small Cap Portfolios which do not have Class B shares) pursuant to Rule 12b-1
under the 1940 Act (each, a "Plan" and collectively, the "Plans"). Under each
Plan the Distributor is entitled to receive as compensation from these
Portfolios a fee, which is accrued daily and paid quarterly, at an annual rate
of up to 0.25% of the average daily net assets of the Class B shares of these
Portfolios. The Plans for the Class B shares were most recently approved by the
Fund's Board of Directors, including those directors who are not "interested
persons" of the Fund as that term is defined in the 1940 Act and who have no
direct or indirect financial interest in the operation of a Plan or in any
agreements related thereto, on December 11, 1997.
 
    The Class B shares commenced operations on January 2, 1996. Therefore, no
Rule 12b-1 fees were paid to the Distributor for the fiscal year ended December
31, 1995. For the fiscal years ended December 31, 1996 and December 31, 1997,
the Fund paid to the Distributor fees of approximately $178,205 and $305,000,
respectively, pursuant to the Distribution Plan in accordance with Rule 12b-1
under the 1940 Act. The Mortgage-Backed Securities, China Growth and MicroCap
Portfolios had not commenced operations as of December 31, 1997.
 
CODE OF ETHICS
 
    The Board of Directors of the Fund has adopted a Code of Ethics under Rule
17j-1 of the 1940 Act which incorporates the Code of Ethics of the Adviser
(together, the "Codes"). The Codes significantly restrict the personal investing
activities of all employees of the Adviser and, as described below, impose
additional, more onerous, restrictions on the Fund's investment personnel.
 
    The Codes require that all employees of the Adviser preclear any personal
securities investment (with limited exceptions, such as government securities).
The preclearance requirement and associated procedures are designed to identify
any substantive prohibition or limitation applicable to the proposed investment.
The substantive restrictions applicable to all employees of the Adviser include
a ban on acquiring any securities in a "hot" initial public offering and a
prohibition from profiting on short-term trading in securities. In addition, no
employee may purchase or sell any security that at the time is
 
                                                                          27
<PAGE>
being purchased or sold (as the case may be), or to the knowledge of the
employee is being considered for purchase or sale, by any fund advised by the
Adviser. Furthermore, the Codes provide for trading "blackout periods" that
prohibit trading by investment personnel of the Fund within periods of trading
by the Fund in the same (or equivalent) security.
 
CONTROL PERSONS AND PRINCIPAL HOLDERS OF SECURITIES
 
    The names and addresses of the holders of 5% or more of the outstanding
shares of any class of the Fund as of April 28, 1998 and the percentage of
outstanding shares of such classes owned beneficially or of record by such
shareholders as of such date are, to Fund management's knowledge, as follows:
 
    ACTIVE COUNTRY ALLOCATION PORTFOLIO:  The Trustees of Columbia University in
the City of New York, 475 Riverside Drive, Suite 401, New York, NY 10115, owned
15% of such Portfolio's total outstanding Class A shares.
 
    Key Trust Company of Ohio, N.A., FBO Oglebay Norton Company, 127 Public
Square, Cleveland, OH 44114, owned 10% of such Portfolio's total outstanding
Class A shares.
 
    University of Illinois Foundation, 1305 West Green Street, Urbana, IL 61801
owned 8% of such Portfolio's total outstanding Class A shares.
 
    Barton M. Biggs, 390 Riversville Road, Greenwich, CT 06830 owned 8% of such
Portfolio's total outstanding Class A shares.
 
    Kinghugh S.A. c/o Morgan Stanley Asset Management Inc., 1221 Avenue of the
Americas, New York, NY 10020, owned 8% of such Portfolio's total outstanding
Class A shares.
 
    State Street Bank & Trust Co., FBO MEMC Pension Plan, 200 Newport Avenue,
North Quincy, MA 02171, owned 7% of such Portfolio's total outstanding Class A
shares.
 
    Sahara Enterprises, Inc., 3 First National Plaza, Suite 2000, Chicago, IL
60602-4260, owned 6% of such Portfolio's total outstanding Class A shares.
 
    Wallace Global Fund, 1990 M Street, Suite 250, Washington, D.C. 20036, owned
6% of such Portfolio's total outstanding Class A shares.
 
    Georgetown Memorial Hospital Depreciation Fund, P.O. Box 1718, Georgetown,
SC 29442-1718, owned 5% of such Portfolio's total outstanding Class A shares.
 
    Fidelity Investments Institutional Operations Co. As Agent For Certain
Employee Benefit Plans, 100 Magellan Way, Covington, KY 41015, owned 83% of such
Portfolio's total outstanding Class B shares.
 
    David M. & Sharon M. Platter, 9 Palmer Lane, Riverside, CT 06878, owned 17%
of such Portfolio's total outstanding Class B shares.
 
    AGGRESSIVE EQUITY PORTFOLIO:  Morgan Stanley & Co. Pension Fund c/o Northern
Trust Co. Custodian, 770 Broadway, New York, NY 10003 owned 14% of such
Portfolio's total outstanding Class A shares.
 
    Ministers and Missionaries Benefit Board of the American Baptist Churches,
Morgan Stanley Asset Management Inc., 1221 Avenue of the Americas, New York, NY
10020 owned 13% of such Portfolio's total outstanding Class A shares.
 
    Bank Morgan Stanley AG, Bahnhogstrasse 92, Zurich CH-8023 Switzerland owned
6% of such Portfolio's total outstanding Class A shares.
 
    ASIAN EQUITY PORTFOLIO:  Association De Biefsaissance Et De Retraite Des
Pollciers De La Communaute Urbaine De Montreal, 480 Gilford Street, Suite 200,
Montreal, Quebec H2J1N3, owned 18% of such Portfolio's total outstanding Class A
shares.
 
    Morgan Stanley & Co. Pension Fund c/o Northern Trust Co. Custodian, 770
Broadway, New York, NY 10003 owned 15% of such Portfolio's total outstanding
Class A shares.
 
    Dim & Co., P.O. Box 9800, Calabasas, CA 91302-9800, owned 12% of such
Portfolio's total outstanding Class B shares.
 
    W.H. O' Brien, P.O. Box 9618, Amarillo, TX 79105-9618, owned 11% of such
Portfolio's total outstanding Class B shares.
 
    Rosekrans Family Partnership, 220 Montgomery Street, Suite 1940, San
Francisco, CA 94104, owned 11% of such Portfolio's total outstanding Class B
shares.
 
    Steve & Julie Gerhardt, 6030 Quail Hill Drive, Cincinnati, OH 45233, owned
8% of such Portfolio's total outstanding Class B shares.
 
    John A. Mansour, 111 Congress Avenue, Suite 3000, Austin, TX 78701-4043,
owned 7% of such Portfolio's total outstanding Class B shares.
 
    28
<PAGE>
    John Mobley, 4807 Spicewood Springs Road, Suite 1245, Stillhouse Canyon
Office Park, Building One, Austin, TX 78759-8435 owned 6% of such Portfolio's
total outstanding Class B shares.
 
    Berl Bernhard and Karen Bernhard, Trustee FBO The Berl Bernhard Trust, 1693
Epping Farms Lane, Annapolis, MD 21401 owned 6% of such Portfolio's total
outstanding Class B shares.
 
    ASIAN REAL ESTATE PORTFOLIO:  Morgan Stanley Asset Management Inc., 1221
Avenue of the Americas, New York, NY 10020, owned 21% of such Portfolio's total
outstanding Class A shares.
 
    Donna Karen c/o Stephen Weiss, The Donna Karen Co., 550 Seventh Avenue, New
York, NY 10018-3201 owned 12% of such Portfolio's total outstanding Class A
shares.
 
    Trustees of Dartmouth College, One Rope Ferry Road, Hanover, NH 03755 owned
9% of such Portfolio's total outstanding Class A shares.
 
    Barry Bergman and Lisa H. Bergman, 42 Overlook Road, Great Neck, NY
11020-1109, owned 44% of such Portfolio's total outstanding Class B shares.
 
    Oliver Trucking Co. Inc., P.O. Box 53, Winchester, KY 40392-0053, owned 35%
of such Portfolio's total outstanding Class B shares.
 
    Kevin L. Jackson, 3112 Grimes Ranch Road, Austin, TX 78732-2124 owned 18% of
such Portfolio's total outstanding Class B shares.
 
    BALANCED PORTFOLIO:  First Bank, N.A. Trustee, Kinney Printing Co., P.O. Box
64010, St. Paul, MN 55154-0010, owned 23% of such Portfolio's total outstanding
Class A shares.
 
    H. Conrad & Sarah Meyer, One Woodland Avenue, Bronxville, NY 10708-3208,
owned 17% of such Portfolio's total outstanding Class A shares.
 
    Jeffery R. Holzschuh, 21 Kenilworth Terrace, Greenwich, CT 06830, owned 11%
of such Portfolio's total outstanding Class A shares.
 
    Guarantee & Trust Company, Trustee FBO H. Conrad Meyer III, IRA Rollover,
One Woodland Avenue, Bronxville, NY 10708-3208, owned 10% of such Portfolio's
total outstanding Class A shares.
 
    William Guthrie, IRA Rollover, MSTC Custodian, 435 Sheridan Road, Winnetka,
IL 60093-2626, owned 62% of such Portfolio's total outstanding Class B shares.
 
    Ramakrishna Kothalanka M.D., Profit Sharing Plan, MSTC Custodian, 126
Bentley Avenue, Jersey City, NJ 07304-1702, owned 38% of such Portfolio's total
outstanding Class B shares.
 
    EMERGING GROWTH PORTFOLIO:  Morgan Stanley & Co. Pension Fund c/o Northern
Trust Co. Custodian, 770 Broadway, New York, NY 10003 owned 54% of such
Portfolio's total outstanding Class A shares.
 
    Allendale Mutual Insurance Co., P.O. Box 7500, Johnston, RI 02919-0750,
owned 20% of such Portfolio's total outstanding Class A shares.
 
    NOAM/A/EC, c/o Philip Winters, Morgan Stanley Asset Management Inc., 1221
6th Avenue, New York, NY 10020, owned 9% of such Portfolio's total outstanding
Class A shares.
 
    Penthouse Manufacturers Co., Inc., 225 Buffalo Avenue, Freeport, NY
11520-4709, owned 7% of such Portfolio's total outstanding Class B shares.
 
    Lawrence M. Howell, Howell Capital, One Maritime Plaza, Suite 1700, San
Francisco, CA 94104, owned 7% of such Portfolio's total outstanding Class B
shares.
 
    Paul E. Blondin, 50 Battery St., Apt. 304, Boston, MA 02109, owned 7% of
such Portfolio's total outstanding Class B shares.
 
    Donald Axinn #2, 131 Jericho Turnpike, Jericho, NY 11753-1017, owned 7% of
such Portfolio's total outstanding Class B shares.
 
    John J. Hogan, Jr., St. Andrews, 10 Old Jackson Avenue, Hastings On Hudson,
NY 10706 owned 7% of such Portfolio's total outstanding Class B shares.
 
    Julian Eisner, 871 Oak Lane, North Woodmere, NY 11581, owned 7% of such
Portfolio's total outstanding Class B shares.
 
    H. Conrad & Sarah Meyer, One Woodland Avenue, Bronxville, NY 10708, owned 6%
of such Portfolio's total outstanding Class B shares.
 
                                                                          29
<PAGE>
    Bruce S. Ives, 163 Gallows Hill Road, West Redding, CT 06896, owned 6% of
such Portfolio's total outstanding Class B shares.
 
    William B. O'Connor, 18 Monfort Road, Port Washington, NY 11050, owned 5% of
such Portfolio's total outstanding Class B shares.
 
    EMERGING MARKETS PORTFOLIO:  Ewing Marion Kauffman Foundation, 4900 Oak
Street, Kansas City, MO 64172-2776 owned 6% of such Portfolio's total
outstanding Class A shares.
 
    Ministers and Missionaries Benefit Board of the American Baptist Churches,
475 Riverside Drive, New York, NY 10115-0049, owned 6% of such Portfolio's total
outstanding Class A shares.
 
    EMERGING MARKETS DEBT PORTFOLIO:  Northwestern University, 633 Clark Street,
Evanston, IL 60208-1122 owned 14% of such Portfolio's total outstanding Class A
shares.
 
    Commonwealth of Pennsylvania Public School Employees Retirement System, 5
North 5th Street, Harrisburg, PA 17101 owned 9% of such Portfolio's total
outstanding Class A shares.
 
    Morgan Stanley & Co. Pension Fund c/o Northern Trust Co. Custodian, 770
Broadway, New York, NY 10003 owned 6% of such Portfolio's total outstanding
Class A shares.
 
    Swarthmore College, 500 College Avenue, Swarthmore, PA 19081-1110 owned 6%
of such Portfolio's total outstanding Class A shares.
 
    Charles Schwab & Co. Inc., 101 Montgomery Street, San Francisco, CA 94104
owned 5% of such Portfolio's total outstanding Class A shares.
 
    Herbert Ross IRA, MSTC Custodian, 160 E. 72nd Street, New York, NY
10021-4364, owned 8% of such Portfolio's total outstanding Class B shares.
 
    Dr. Russell Warren, IRA, MSTC Custodian, 215 John St., Greenwich, CT
06831-2516, owned 7% of such Portfolio's total outstanding Class B shares.
 
    Papapopen L.P., P.O. Box 21830, Shreveport, LA 71120, owned 6% of such
Portfolio's total outstanding Class B shares.
 
    EQUITY GROWTH PORTFOLIO:  Fidelity Management Trust Company as Trustee for
GTE Master Savings Trust, 82 Devonshire Street, Boston, MA 02109, owned 18% of
such Portfolio's total outstanding Class A shares.
 
    Morgan Stanley & Co. Pension Fund c/o Northern Trust Co. Custodian, 770
Broadway, New York, NY 10003 owned 16% of such Portfolio's total outstanding
Class A shares.
 
    Fidelity Investments Institutional Operations Company As Agent for Certain
Employee Benefit Plans, 100 Magellan Way, Covington, KY 41015, owned 11% of such
Portfolio's total outstanding Class A shares.
 
    Bankers Trust Co. As Custodian For Marriott International Inc. Employees'
Profit Sharing, Retirement and Savings Plan and Trust, 100 Plaza One, Jersey
City, NJ 073111-3999 owned 45% of such Portfolio's total outstanding Class B
shares.
 
    Bankers Trust, Trustee for Marriott Services Inc., 401k Employees Retirement
Savings Plan, 100 Plaza One, Jersey City, NJ 07311-3999, owned 18% of such
Portfolio's total outstanding Class B shares.
 
    FNB Nominee Co., c/o First Commonwealth Trust, 614 Philadelphia St.,
Indiana, PA 15701, owned 14% of such Portfolio's total outstanding Class B
shares.
 
    EUROPEAN EQUITY PORTFOLIO:  Wayne Gretzky, Trustee of the Gretzky Trust of
1989, 9100 Wilshire Blvd, Suite 10000, Beverly Hills, CA 90210, owned 7% of such
Portfolio's total outstanding Class B shares.
 
    David Weiss and Andrew Nelson, Trustees, FAO The Adam Williams 1998
Irrevocable Trust, 30752 Paseo Del Niguel, Laguna Niguel, CA 92677, owned 7% of
such Portfolio's total outstanding Class B shares.
 
    EUROPEAN REAL ESTATE PORTFOLIO:  Mantucket LLC, Re: Kenra, 5910 S.
University Blvd., Littleton, CO 80121-2800, owned 8% of such Portfolio's total
outstanding Class A shares.
 
    Irene R. Miller & Anoush Khoshkish, 186 Riverside Drive, Apt 10E, New York,
NY 10024-1007 owned 9% of such Portfolio's total outstanding Class B shares.
 
    Donald E. Axinn, 131 Jericho Turnpike, Jericho, NY 11753-1017 owned 9% of
such Portfolio's total outstanding Class B shares.
 
    Oliver Trucking Co. Inc., Attn: David Oliver, P.O. Box 53, Winchester, KY
40392-0053, owned 8% of such Portfolio's total outstanding Class B shares.
 
    30
<PAGE>
    Robert T. Manfuso, 8401 Connecticut Avenue, Chevy Chase, MD 20815-5803 owned
6% of such Portfolio's total outstanding Class B shares.
 
    Della Golbus Self Declaration of Trust, 5701 North Sheridan, Chicago, IL
60660 owned 5% of such Portfolio's total outstanding Class B shares.
 
    John Segal Special Trust. No 1, 1373 Brinkley Avenue, Los Angeles, CA,
90049-3619 owned 5% of such Portfolio total outstanding Class B shares.
 
    FIXED INCOME PORTFOLIO:  Morgan Stanley & Co. Pension Fund c/o Northern
Trust Co. Custodian, 770 Broadway, New York, NY 10003 owned 26% of such
Portfolio's total outstanding Class A shares.
 
    Burton D. Cohen, 3912 Zenith Avenue South, Minneapolis, MN 55410-1169, owned
8% of such Portfolio's total outstanding Class B shares.
 
    Michael S. Virgil, Trustee, Mary Ann Young Brownsey Trust, 330 N. Wabash
Avenue, 22nd Floor, Chicago, IL 60611, owned 7% of such Portfolio's total
outstanding Class B shares.
 
    Max Jeffrey Baum, IRA Rollover, MSTC Custodian, 620 Green Bay Road, Highland
Park, IL 60035, owned 7% of such Portfolio's total outstanding Class B shares.
 
    Joan M. Hunt Trust, 8627 Madison Drive, Niles, IL 60648, owned 6% of such
Portfolio's total outstanding Class B shares.
 
    Laverne M. Brownsey Trust, 330 N. Wabash Avenue, 22nd Floor, Chicago, IL
60611-3603, owned 6% of such Portfolio's total outstanding Class B shares.
 
    Catholic Medical Center of Brooklyn & Queens, Inc., Deferred Compensation
Plan, 88-25 153rd Street, Apt. 1-C, Jamaica, NY 11432-3748, owned 5% of such
Portfolio's total outstanding Class B shares.
 
    GLOBAL EQUITY PORTFOLIO:  Ministers and Missionaries Benefit Board of the
American Baptist Churches, 475 Riverside Drive, New York, NY 10115-0049 owned
33% of such Portfolio's total outstanding Class A shares.
 
    Robert College of Istanbul Turkey c/o Morgan Stanley Asset Management Inc.,
1221 Avenue of the Americas, New York, NY 10020, owned 26% of such Portfolio's
total outstanding Class A shares.
 
    JM Kaplan Fund, Inc., 880 Third Avenue, 3rd Floor, New York, NY 10022, owned
7% of such Portfolio's total outstanding Class A shares.
 
    Charles Schwab & Co. Inc., 101 Montgomery Street, San Francisco, CA 94104,
owned 6% of such Portfolio's total outstanding Class A shares.
 
    Kaplan, Choate Value Partners, L.P., 880 Third Avenue, New York, NY
10022-4730, owned 5% of such Portfolio's total outstanding Class A shares.
 
    Fidelity Investments Institutional Operations Co. as Agent for Certain
Employee Benefit Plans, 100 Magellan Way, Covington, KY 41015, owned 29% of such
Portfolio's total outstanding Class B shares.
 
    GLOBAL FIXED INCOME PORTFOLIO:  American Industries Trust Company Inc.,
Trustee for AG First Farm Credit Bank Retirement Plan, 5700 NW Central Drive,
4th Floor, Houston, TX 77092, owned 26% of such Portfolio's total outstanding
Class A shares.
 
    Northern Trust Company as Custodian, FBO The Lund Foundation, P.O. Box
92956, Chicago, IL 60675, owned 21% of such Portfolio's total outstanding Class
A shares.
 
    Northern Trust Company as Custodian, FBO The LBD Foundation, P.O. Box 92956,
Chicago, IL 60675, owned 8% of such Portfolio's total outstanding Class A
shares.
 
    National Bank of Commerce Trustee, FBO National Bank of Commerce Pension
Plan, c/o NBC Trust Dept., One Commerce Square, Memphis, TN 38150, owned 7% of
such Portfolio's total outstanding Class A shares.
 
    Radiology Associates PA, Employee Benefit Plan, 500 South University, Suite
604, Little Rock, AR 72205 owned 7% of such Portfolio's total outstanding Class
A shares.
 
    Investment and Research In Education c/o Philip W. Winters, Morgan Stanley
Asset Management Inc., 1221 Avenue of the Americas, New York, NY 10020, owned 6%
of such Portfolio's total outstanding Class A shares.
 
    David Brooks Gendron, 2 Montpelier Place, London SW7 1HJ, England, UK, owned
67% of such Portfolio's total outstanding Class B shares.
 
    George N. Fugelsang & Susan P. Fugelsang, 17 Calhoun Drive, Greenwich, CT
06831, owned 19% of such Portfolio's total outstanding Class B shares.
 
    Anthony F. Rowland and Colette H. Rowland, c/o Cambrian Management, 1114
Avenue of the Americas #2702, New York, NY 10036-7703, owned 11% of such
Portfolio's total outstanding Class B shares.
 
                                                                          31
<PAGE>
    HIGH YIELD PORTFOLIO:  Morgan Stanley & Co. Pension Fund c/o Northern Trust
Co. Custodian, 770 Broadway, New York, NY 10003 owned 17% of such Portfolio's
total outstanding Class A shares.
 
    Briarwoods Insurance Company Ltd., c/o Gavin Cray, Midland Bank Building,
P.O. Box 1109, Grand Cayman BWI owned 11% of such Portfolio's total outstanding
Class A shares.
 
    Granite Properties Management Corp. c/o Keith Suehnolz, One Cablevision
Center, Liberty, NY 12754 owned 7% of such Portfolio's total outstanding Class A
shares.
 
    INTERNATIONAL EQUITY PORTFOLIO:  Memphis Commerce Square, c/o National Bank
of Commerce Trust Division, One Commerce Square, Memphis, TN 38150, owned 51% of
such Portfolio's total outstanding Class B shares.
 
    Vanguard Fiduciary Trust Company, FBO Ball Corp. Plan 91324, The Vanguard
Group, P.O. Box 2600, Valley Forge, PA 19482, owned 17% of such Portfolio's
total outstanding Class B shares.
 
    INTERNATIONAL MAGNUM PORTFOLIO:  Bankers Trust, Trustee Harris Corporation
Retirement Plan and Harris Corporation Union Retirement Plan, 1025 W. Nasa
Blvd., Melbourne, FL 32919 owned 20% of such Portfolio's total outstanding Class
A shares.
 
    Lutheran Brotherhood, 625 Fourth Avenue S., Minneapolis, MN 55415 owned 9%
of such Portfolio's total outstanding Class A shares.
 
    Fidelity Investments Institutional Operations Co. As Agent for Certain
Employee Benefit Plans, 100 Magellan Way, Covington, KY 41015, owned 72% of such
Portfolio's total outstanding Class B shares.
 
    INTERNATIONAL SMALL CAP PORTFOLIO:  The Skillman Foundation, Attn: Jean E.
Gregory, 600 Renaissance Center, Suite 1700, Detroit, MI 48243, owned 10% of
such Portfolio's total outstanding Class A shares.
 
    Trustees of Boston College Attn: Paul Haran Associate Treasurer, St. Thomas
More Hall 310, Chestnut Hill, MA 02167, owned 7% of such Portfolio's total
outstanding Class A shares.
 
    General Mills, Inc. Master Trust: Pooled International Fund, One General
Mills Blvd., Minneapolis, MN 55426, owned 7% of such Portfolio's total
outstanding Class A shares.
 
    State Street Bank & Trust Co. As Trustee for Nissan Retirement Savings Plan,
P.O. Box 1992, Boston, MA 02105-1992, owned 6% of such Portfolio's total
outstanding Class A shares.
 
    Cornell University, c/o Gail Reeke, Morgan Stanley Asset Management Inc.,
1221 Avenue of the Americas, New York, NY 10020, owned 5% of such Portfolio's
total outstanding Class A shares.
 
    JAPANESE EQUITY PORTFOLIO:  The Northern Trust Company as Trustee FBO
Portland General Holdings, Inc. Investment Plan Trust, 121 SW Salmon Street,
Portland, OR 97204 owned 8% of such Portfolio's total outstanding Class A
shares.
 
    John A. Mansour, 111 Congress Avenue, Suite 3000, Austin, TX 78701-4043,
owned 28% of such Portfolio's total outstanding Class B shares.
 
    Barlett and Company Profit Sharing Plan and Trust, 4800 Main Street, Suite
600, Kansas City, MO 64112, owned 16% of such Portfolio's total outstanding
Class B shares.
 
    Kimtar Investments LLC, P.O. Box 2720, Wilmington, DE 19805-0720, owned 14%
of such Portfolio's total outstanding Class B shares.
 
    Darwin K. Hoop, 2315 Lancashire Drive 1A, Ann Harbor, MI 48105-1357 owned 6%
of such Portfolio's total outstanding Class B shares.
 
    Mark A. Kelton, 2716 Ocean Park Blvd., Santa Monica, CA 90405 owned 6% of
such Portfolio's total outstanding Class B shares.
 
    Wayne Gretzky Trustee of the Gretzky Trust of 1989, 9100 Wilshire Blvd.,
Suite 10000, Beverly Hills, CA 90210, owned 6% of such Portfolio's total
outstanding Class B shares.
 
    LATIN AMERICAN PORTFOLIO:  The Hostetter Foundation, The Pilot House, Lewis
Wharf, Boston MA 02110 owned 11% of such Portfolio's total outstanding Class A
shares.
 
    Richard L. Scott and F. Annette Scott Family Limited Partnership, 104
Woodmont Blvd., Suite 101, Nashville, TN 37205 owned 7% of such Portfolio's
total outstanding Class A shares.
 
    T.R. Ansco & Company, P.O. Box 48698, Wichita, KS 67201, owned 16% of such
Portfolio's total outstanding Class B shares.
 
    32
<PAGE>
    MONEY MARKET PORTFOLIO:  Bruce R. McCaw, P.O. Box 1717, Bellevue, WA
98009-1717 owned 8% of such Portfolio's total outstanding Class A shares.
 
    MUNICIPAL BOND PORTFOLIO:  Frank R. Mori, 935 Park Avenue, Apt. #16A, New
York, NY 10028-0212 owned 13% of such Portfolio's total outstanding Class A
shares.
 
    Cushman Trust, c/o Cambrian Services, 1114 Avenue of the Americas, Suite
2702, New York, NY 10036 owned 12% of such Portfolio's total outstanding Class A
shares.
 
    Donna Karen c/o Stephen Weiss, The Donna Karen Co., 550 Seventh Avenue, New
York, NY 10018-3201 owned 6% of such Portfolio's total outstanding Class A
shares.
 
    William E. Noyes and Colleen A. Noyes, 260 Otis Road, Barrington, IL
60010-5124 owned 6% of such Portfolio's total outstanding Class A shares.
 
    SMALL CAP VALUE EQUITY PORTFOLIO:  James E. Himoff, IRA Rollover, 7201 State
Route 8, Brant Lake, NY 12815-2236, owned 5% of such Portfolio's total
outstanding Class B shares.
 
    TECHNOLOGY PORTFOLIO:  Valassis Enterprises c/o Franklin Enterprises, 520
Lake Cook Road, Suite 380, Deerfield, IL 60015 owned 16% of such Portfolio's
total outstanding Class A shares.
 
    Bruce W. Bastian and McKay S. Matthews Trustees FBO Bruce W. Bastian
Charitable Trust, 51 West Center #755, Orem, UT 84057-4605 owned 15% of such
Portfolio's total outstanding Class A shares.
 
    Kinghugh S.A. c/o Morgan Stanley Asset Management Inc., 1221 Avenue of the
Americas, New York, NY 10020 owned 10% of such Portfolio's total outstanding
Class A shares.
 
    U.S. EQUITY PLUS PORTFOLIO:  Morgan Stanley Asset Management Inc., Attn:
Elisa Divito, 1221 Avenue of the Americas, New York, NY 10020, owned 42% of such
Porfolio's total outstanding Class A shares.
 
    The Flinn Foundation, Northern Trust Co., Attn: Thomas Hackett, Master Trust
Department, 7th Floor, P.O. Box 92984, Chicago, IL 60675, owned 37% of such
Portfolio's total outstanding Class A shares.
 
    Merchants National Bank of Aurora, Attn: Terrence Kothe, Sr. VP, P.O. Box
289 Aurora, IL 60507-2089, owned 10% of such Portfolio's outstanding Class A
shares.
 
    Memphis Commerce Square c/o National Bank of Commerce, Trust Division, One
Commerce Square, Memphis, TN 38150, owned 65% of such Portfolio's total
outstanding Class B shares.
 
    Gururai Deshpande, 9 Sparta Way, Andover, MA 01810, owned 16% of such
Portfolio's total outstanding Class B shares.
 
    Lawrence Menaker and Cecelia Menaker, 734 Ninth Street, Wilmette, IL
60091-2616, owned 10% of such Portfolio's total outstanding Class B shares.
 
    Paul E. Blondin, 50 Battery St., Apt. 304, Boston, MA 02109, owned 9% of
such Portfolio's total outstanding Class B shares.
 
    U.S. REAL ESTATE PORTFOLIO:  The Northern Trust As Trustee FBO Anderson
Worldwide Profit Sharing 401k Retirement Trust, P.O. Box 92956, Chicago, IL
60675 owned 13% of such Portfolio's total outstanding Class A shares.
 
    Northwestern University, 633 Clark Street, Evanston, IL 60208-1122 owned 8%
of such Portfolio's total outstanding Class A shares.
 
    Commonwealth of Pennsylvania Public School Employees Retirement System, 5
North 5th Street, Harrisburg, PA 17101 owned 6% of such Portfolio's total
outstanding Class A shares.
 
    Morgan Stanley & Co. Pension Fund c/o Northern Trust Company Custodian, 770
Broadway, New York, NY 10003 owned 5% of such Portfolio's total outstanding
Class A shares.
 
    Merrill Lynch Trust Co., Trustee FBO Qualified Retirement Plans, 265
Davidson Avenue, 4th Floor, Somerset, NJ 08873, owned 51% of such Portfolio's
total outstanding Class B shares.
 
    VALUE EQUITY PORTFOLIO:  The World Bank, 1818 H Street, Washington, DC
20433, owned 10% of such Portfolio's total outstanding Class A shares.
 
    Paul D. Bartlett, Jr., 4800 Main Street, Suite 600, Kansas City, MO 64112,
owned 12% of such Portfolio's total outstanding Class B shares.
 
    R. Douglas Spedding, Trustee of R. Douglas Spedding 1996 Trust, c/o ROS 4380
E. Alameda, Glendale, CO 80222, owned 10% of such Portfolio's total outstanding
Class B shares.
 
                                                                          33
<PAGE>
    Arthur Logan Harris Holmes & Phyllis Janet Holmes, Trustees of the Holmes
Family Trust, 1701 Monte Viento Drive, Malibu, CA 90265-3025, owned 8% of such
Portfolio's total outstanding Class B shares.
 
    David Brooks Gendron, 2 Montpelier Place, London SW7 1HJ England, UK, owned
8% of such Portfolio's total outstanding Class B shares.
 
    George N. Fugelsang and Susan P. Fugelsang, 17 Calhoun Drive, Greenwich, CT
06831 owned 6% of such Portfolio's total outstanding Class B shares.
 
                  NET ASSET VALUE FOR MONEY MARKET PORTFOLIOS
 
    The Money Market Portfolio and the Municipal Money Market Portfolio seek to
maintain a stable net asset value per share of $1.00. These Portfolios use the
amortized cost method of valuing their securities, which does not take into
account unrealized gains or losses. The use of amortized cost and the
maintenance of each Portfolio's per share net asset value at $1.00 is based on
the Portfolio's election to operate under the provisions of Rule 2a-7 under the
1940 Act. As a condition of operating under that Rule, each of the Money Market
Portfolios must maintain a dollar-weighted average portfolio maturity of 90 days
or less, purchase only instruments having remaining maturities of 397 days or
less, and invest only in securities which are of "eligible quality" as
determined in accordance with regulations of the Commission.
 
    The Rule also requires that the Directors, as a particular responsibility
within the overall duty of care owed to shareholders, establish procedures
reasonably designed, taking into account current market conditions and each
Portfolio's investment objectives, to stabilize the net asset value per share as
computed for the purposes of sales and redemptions at $1.00. These procedures
include periodic review, as the Directors deem appropriate and at such intervals
as are reasonable in light of current market conditions, of the relationship
between the amortized cost value per share and a net asset value per share based
upon available indications of market value. In such review, investments for
which market quotations are readily available are valued at the most recent bid
price or quoted yield available for such securities or for securities of
comparable maturity, quality and type as obtained from one or more of the major
market makers for the securities to be valued. Other investments and assets are
valued at fair value, as determined in good faith by the Directors.
 
    In the event of a deviation of over 1/2 of 1% between a Portfolio's net
asset value based upon available market quotations or market equivalents and
$1.00 per share based on amortized cost, the Directors will promptly consider
what action, if any, should be taken. The Directors will also take such action
as they deem appropriate to eliminate or to reduce to the extent reasonably
practicable any material dilution or other unfair results which might arise from
differences between the two. Such action may include redemption in kind, selling
instruments prior to maturity to realize capital gains or losses or to shorten
the average maturity, withholding dividends, paying distributions from capital
or capital gains or utilizing a net asset value per share as determined by using
available market quotations.
 
    There are various methods of valuing the assets and of paying dividends and
distributions from a money market fund. Each of the Money Market and Municipal
Money Market Portfolios values its assets at amortized cost while also
monitoring the available market bid price, or yield equivalents. Since dividends
from net investment income will be declared daily and paid monthly, the net
asset value per share of each Portfolio will ordinarily remain at $1.00, but
each Portfolio's daily dividends will vary in amount. Net realized gains, if
any, will normally be declared and paid monthly.
 
                            PERFORMANCE INFORMATION
 
    The Fund may from time to time quote various performance figures to
illustrate the Portfolios' past performance.
 
    Performance quotations by investment companies are subject to rules adopted
by the Commission, which require the use of standardized performance quotations.
In the case of total return, non-standardized performance quotations may be
furnished by the Fund but must be accompanied by certain standardized
performance information computed as required by the Commission. Current yield
and average annual compounded total return quotations used by the Fund are based
on the standardized methods of computing performance mandated by the Commission.
An explanation of those and other methods used by the Fund to compute or express
performance follows.
 
TOTAL RETURN
 
    From time to time each Portfolio, except the Money Market and Municipal
Money Market Portfolios, may advertise total return for each class of shares of
the Portfolio. Total return figures are based on historical earnings and are not
intended to indicate future performance. The average annual total return is
determined by finding the average annual compounded rates of return over 1-, 5-,
and 10-year periods (or over the life of the Portfolio) that would equate an
initial hypothetical $1,000 investment to its ending redeemable value. The
calculation assumes that all dividends and distributions are reinvested when
paid. The quotation assumes the amount was completely redeemed at the end of
each 1-, 5-, and 10-year period (or over the life of the Portfolio) and the
deduction of all applicable Fund expenses on an annual basis.
 
    34
<PAGE>
    The average annual compounded rates of return (unless otherwise noted) for
the Fund's Portfolios for the one year and five year periods ended December 31,
1997 and for the period from inception through December 31, 1997 are as follows:
 
<TABLE>
<CAPTION>
                                                                                             AVERAGE ANNUAL
                                                    INCEPTION     ONE       AVERAGE ANNUAL       SINCE
NAME OF PORTFOLIO+                                    DATE        YEAR        FIVE YEARS       INCEPTION
- --------------------------------------------------  ---------  ----------   --------------   --------------
<S>                                                 <C>        <C>          <C>              <C>
Active Country Allocation
  Class A.........................................    1/17/92        8.61%       11.37%            8.69%
  Class B.........................................    1/02/96        8.35%         N/A             7.65%
Aggressive Equity
  Class A.........................................    3/08/95       33.31%         N/A            41.36%
  Class B.........................................    1/02/96       32.90%         N/A            36.62%
Asian Equity
  Class A.........................................    7/01/91      (48.29)%      (0.14)%           4.16%
  Class B.........................................    1/02/96      (48.48)%        N/A           (27.21)%
Asian Real Estate
  Class A.........................................   10/01/97      (19.92)%*        N/A             N/A
  Class B.........................................   10/01/97      (19.70)%*        N/A             N/A
Balanced
  Class A.........................................    2/20/90       17.30%       11.98%           11.25%
  Class B.........................................    1/02/96       16.94%         N/A            13.56%
Emerging Growth
  Class A.........................................   11/01/89       11.36%        8.88%           11.88%
  Class B.........................................    1/02/96       11.13%         N/A             7.30%
Emerging Markets
  Class A.........................................    9/25/92       (1.03)%      10.23%           10.13%
  Class B.........................................    1/02/96       (1.31)%        N/A             4.69%
Emerging Markets Debt
  Class A.........................................    2/01/94       18.29%         N/A            18.77%
  Class B.........................................    1/02/96       18.05%         N/A            32.46%
Equity Growth
  Class A.........................................    4/02/91       31.32%       21.86%           19.07%
  Class B.........................................    1/02/96       31.05%         N/A            30.53%
European Equity
  Class A.........................................    4/02/93       17.88%         N/A            19.25%
  Class B.........................................    1/02/96       17.73%         N/A            19.26%
European Real Estate
  Class A.........................................   10/01/97       (4.76)%*        N/A             N/A
  Class B.........................................   10/01/97       (4.76)%*        N/A             N/A
Fixed Income
  Class A.........................................    5/15/91        9.54%        7.54%            8.53%
  Class B.........................................    1/02/96        9.48%         N/A             6.89%
Global Equity
  Class A.........................................    7/15/92       23.75%       22.71%           20.03%
  Class B.........................................    1/02/96       23.37%         N/A            22.74%
Global Fixed Income
  Class A.........................................    5/01/91        1.50%        6.91%            7.42%
  Class B.........................................    1/02/96        1.29%         N/A             3.68%
Gold
  Class A.........................................    2/01/94      (55.64)%        N/A           (14.67)%
  Class B.........................................    1/02/96      (55.17)%        N/A           (28.74)%
High Yield
  Class A.........................................    9/28/92       15.87%       13.98%           13.46%
  Class B.........................................    1/02/96       15.48%         N/A            14.94%
International Equity
  Class A.........................................    8/04/89       13.91%       20.19%           12.19%
  Class B.........................................    1/02/96       13.57%         N/A            16.07%
International Magnum
  Class A.........................................    3/15/96        6.58%*        N/A             8.28%
  Class B.........................................    3/15/96        6.33%*        N/A             7.94%
International Small Cap
  Class A.........................................   12/15/92       (0.55)%      12.76%           12.84%
</TABLE>
 
                                                                          35
<PAGE>
<TABLE>
<CAPTION>
                                                                                             AVERAGE ANNUAL
                                                    INCEPTION     ONE       AVERAGE ANNUAL       SINCE
NAME OF PORTFOLIO+                                    DATE        YEAR        FIVE YEARS       INCEPTION
- --------------------------------------------------  ---------  ----------   --------------   --------------
<S>                                                 <C>        <C>          <C>              <C>
Japanese Equity
  Class A.........................................    4/25/94       (9.23)%        N/A            (4.38)%
  Class B.........................................    1/02/96       (9.64)%        N/A            (5.75)%
Latin American
  Class A.........................................    1/18/95       41.28%         N/A            24.70%
  Class B.........................................    1/02/96       40.37%         N/A            41.47%
Municipal Bond
  Class A.........................................    1/18/95        7.25%         N/A             6.66%
  Class B.........................................    1/02/96       (0.01)%**        N/A            N/A
Small Cap Value Equity
  Class A.........................................   12/17/92       36.80%       18.30%           18.46%
  Class B.........................................    1/02/96       36.51%         N/A            29.27%
Technology
  Class A.........................................    9/16/96       37.27%         N/A            34.80%
  Class B.........................................    9/16/96       36.90%         N/A            34.52%
U.S. Equity Plus
  Class A.........................................    7/31/97        3.94%*        N/A              N/A
  Class B.........................................    7/31/97        3.93%*        N/A              N/A
U.S. Real Estate
  Class A.........................................    2/24/95       27.62%         N/A            30.92%
  Class B.........................................    1/02/96       27.21%         N/A            32.66%
Value Equity
  Class A.........................................    1/31/90       29.20%       18.64%           14.89%
  Class B.........................................    1/02/96       28.70%         N/A            23.56%
</TABLE>
 
- ------------------
 + The China Growth, Mortgage-Backed Securities and MicroCap Portfolios had not
   commenced operations as of December 31, 1997.
 * Cumulative (unannualized) total return since inception of the Portfolio.
**Per share amounts for the year ended December 31, 1997 and for the period
  ended November 5, 1997 are based on average shares outstanding. As of November
  5, 1997, and for the period from March 19 through October 30, 1997, there were
  no outstanding Class B shares for the Municipal Bond Portfolio.
 
    These figures were calculated according to the following formula:
 
<TABLE>
<C>                             <C>    <S>
       P(1+T)to the power of n    =    ERV
</TABLE>
 
    where:
 
<TABLE>
<C>         <C>        <S>
         P      =      a hypothetical initial payment of $1,000
         T      =      average annual total return
         n      =      number of years
       ERV      =      ending redeemable value of hypothetical $1,000 payment made at the beginning
                       of the 1-, 5-, or 10-year periods at the end of the 1-, 5-, or 10-year
                       periods (or fractional portion thereof).
</TABLE>
 
CALCULATION OF YIELD FOR NON-MONEY MARKET PORTFOLIOS
 
    From time to time certain of the Fund's Portfolios may advertise yield.
 
    Current yield reflects the income per share earned by a Portfolio's
investments.
 
    Current yield is determined by dividing the net investment income per share
earned during a 30-day base period by the maximum offering price per share on
the last day of the period and annualizing the result. Expenses accrued for the
period include any fees charged to all shareholders during the base period.
 
    The respective current yields for certain of the Fund's Portfolios for the
30-day period ended December 31, 1997 were as follows:
 
<TABLE>
<CAPTION>
                                                     CLASS A
PORTFOLIO NAME                                       SHARES    CLASS B SHARES
- --------------------------------------------------  ---------  --------------
<S>                                                 <C>        <C>
Emerging Markets Debt.............................     10.24%         9.95%
Fixed Income......................................      5.95%         5.80%
Global Fixed Income...............................      4.87%         4.72%
High Yield........................................      8.34%         8.10%
Municipal Bond....................................      4.20%           --%
</TABLE>
 
    36
<PAGE>
    These figures were obtained using the following formula:
 
    Yield = 2 [( (a-b) + 1)(6) - 1 ]
                 -----
                  (cd)
 
CALCULATION OF YIELD FOR MONEY MARKET PORTFOLIOS
 
    The current yield of the Money Market and Municipal Money Market Portfolios
is calculated daily on a base period return for a hypothetical account having a
beginning balance of one share for a particular period of time (generally 7
days). The return is determined by dividing the net change (exclusive of any
capital changes in such account) by its average net asset value for the period,
and then multiplying it by 365/7 to determine the annualized current yield. The
calculation of net change reflects the value of additional shares purchased with
the dividends by the Portfolio, including dividends on both the original share
and on such additional shares. The current yields of the Money Market and
Municipal Money Market Portfolios for the 7-day period ended December 31, 1997
were 5.25% and 3.40%, respectively. An effective yield, which reflects the
effects of compounding and represents an annualization of the current yield with
all dividends reinvested, may also be calculated for each Portfolio by dividing
the base period return by 7, adding 1 to the quotient, raising the sum to the
365th power, and subtracting 1 from the result. The effective yields of the
Money Market and Municipal Money Market Portfolios for the 7-day period ended
December 31, 1997 were 5.39% and 3.46%, respectively.
 
    The yield of a Portfolio will fluctuate. The annualization of a week's
dividend is not a representation by the Portfolio as to what an investment in
the Portfolio will actually yield in the future. Actual yields will depend on
such variables as investment quality, average maturity, the type of instruments
the Portfolio invests in, changes in interest rates on instruments, changes in
the expenses of the Fund and other factors. Yields are one basis investors may
use to analyze the Portfolios of the Fund, and other investment vehicles;
however, yields of other investment vehicles may not be comparable because of
the factors set forth in the preceding sentence, differences in the time periods
compared, and differences in the methods used in valuing portfolio instruments,
computing net asset value and calculating yield.
 
TAXABLE EQUIVALENT YIELDS FOR THE MUNICIPAL BOND AND MUNICIPAL MONEY MARKET
PORTFOLIOS
 
    It is easy to calculate your own taxable equivalent yield if you know your
tax bracket. The formula is:
 
<TABLE>
<C>                   <C>        <S>
   Tax Free Yield
- -------------------       =      Your Taxable Equivalent
1 - Your Tax Bracket             Yield
</TABLE>
 
    For example, if you are in the 28% tax bracket and can earn a tax-free yield
of 7.5%, the taxable equivalent yield would be 10.42%.
 
    The table below indicates the advantages of investments in Municipal Bonds
for certain investors. Tax-exempt rates of interest payable on a Municipal Bond
(shown at the top of each column) are equivalent to the taxable yields set forth
opposite the respective income tax levels, based on income tax rates effective
for the tax year 1997 under the Internal Revenue Code. There can, of course, be
no guarantee that the Municipal Bond Portfolio or Municipal Money Market
Portfolio will achieve a specific yield. Also, it is possible that some portion
of the Portfolio's dividends may be subject to Federal income taxes. A
substantial portion, if not all, of such dividends may be subject to state and
local taxes.
 
                                                                          37
<PAGE>
                         TAXABLE EQUIVALENT YIELD TABLE
 
<TABLE>
<CAPTION>
           SAMPLE LEVEL OF              FEDERAL
           TAXABLE INCOME               INCOME       TAXABLE EQUIVALENT RATES BASED ON TAX-EXEMPT YIELD OF:
- -------------------------------------    TAX    -----------------------------------------------------------------
  JOINT RETURN       SINGLE RETURN      BRACKETS  3%    4%     5%     6%     7%      8%      9%      10%     11%
- -----------------  ------------------   -----   ----   ----   ----   ----   -----   -----   -----   -----   -----
<S>                <C>                  <C>     <C>    <C>    <C>    <C>    <C>     <C>     <C>     <C>     <C>
$0-39,000          $0-23,350            15.0%   3.5%   4.7%   5.9%   7.1%    8.2%    9.4%   10.6%   11.8%   12.9%
39,000-94,250      23,350-56,550        28.0    4.2    5.6    6.9    8.3     9.7    11.1    12.5    13.9    15.3
94,250-143,600     56,550-117,950       31.0    4.3    5.8    7.2    8.7    10.1    11.6    13.0    14.5    15.9
143,600-256,500    117,950-256,500      36.0    4.7    6.3    7.8    9.4    10.9    12.5    14.1    15.6    17.2
over 256,500       over 256,500         39.6    5.0    6.6    8.3    9.9    11.6    13.2    14.9    16.6    18.2
</TABLE>
 
- ------------------
* Net amount subject to 1997 Federal Income Tax after deductions and exemptions,
  not indexed for 1996 income tax rates.
 
    The taxable equivalent yields for the Municipal Money Market and Municipal
Bond Portfolios for the seven days ended December 31, 1997 assuming a Federal
income tax rate of 39.6% (maximum rate), were 5.60% and 6.16%, respectively. The
taxable equivalent effective yields for the Municipal Money Market and Municipal
Bond Portfolios for the seven days ended December 31, 1997, assuming the same
tax rate, were 5.68% and 6.27%, respectively.
 
COMPARISONS
 
    To help investors better evaluate how an investment in a Portfolio of Morgan
Stanley Institutional Fund, Inc. might satisfy their investment objective,
advertisements regarding the Fund may discuss various measures of Fund
performance as reported by various financial publications. Advertisements may
also compare performance (as calculated above) to performance as reported by
other investments, indices and averages. The following publications may be used:
 
    (a) CDA Mutual Fund Report, published by CDA Investment Technologies, Inc.
- -- analyzes price, current yield, risk, total return and average rate of return
(average annual compounded growth rate) over specified time periods for the
mutual fund industry.
 
    (b) Financial publications: Business Week, Changing Times, Financial World,
Forbes, Fortune, Money, Barron's, Consumer's Digest, Financial Times, Global
Investor, Investor's Daily, Lipper Analytical Services, Inc., Morningstar, Inc.,
New York Times, Personal Investor, Wall Street Journal and Weisenberger
Investment Companies Service -- publications that rate fund performance over
specified time periods.
 
    (c) Historical data supplied by the research departments of C.S. First
Boston Corporation, the J.P. Morgan companies, Salomon Smith Barney, Merrill
Lynch, Pierce, Fenner & Smith, Lehman Brothers and Bloomberg L.P.
 
    (d) Lipper -- Mutual Fund Performance Analysis and Lipper -- Fixed Income
Fund Performance Analysis -- measures total return and average current yield for
the mutual fund industry. Ranks individual mutual fund performance over
specified time periods, assuming reinvestment of all distributions, exclusive of
any applicable sales charges.
 
    (e) Mutual Fund Source Book, published by Morningstar, Inc. -- analyzes
price, yield, risk and total return for equity funds.
 
    (f) Savings and Loan Historical Interest Rates -- as published in the U.S.
Savings & Loan League Fact Book.
 
    (g) Stocks, Bonds, Bills and Inflation, published by Hobson Associates --
historical measure of yield, price and total return for common and small company
stock, long-term government bonds, U.S. Treasury bills and inflation.
 
    The following indices and averages may also be used:
 
    (a) Composite Indices -- 70% Standard & Poor's 500 Stock Index and 30%
NASDAQ Industrial Index; 35% Standard & Poor's 500 Stock Index and 65% Salomon
Brothers High Grade Bond Index; and 65% Standard & Poor's 500 Stock Index and
35% Salomon Brothers High Grade Bond Index.
 
    (b) Consumer Price Index (or cost of Living Index), published by the U.S.
Bureau of Labor Statistics -- a statistical measure of change, over time, in the
price of goods and services in major expenditure groups.
 
    (c) Donoghue's Money Fund Average -- an average of all major money market
fund yields, published weekly for 7 and 30-day yields.
 
    (d) Dow Jones Composite Average or its component averages -- an unmanaged
index composed of 30 blue-chip industrial corporation stocks (Dow Jones
Industrial Average), 15 utilities company stocks and 20 transportation stocks.
Comparisons of performance assume reinvestment of dividends.
 
    (e) CS First Boston High Yield Index -- generally includes over 180 issues
with an average maturity range of seven to ten years with a minimum
capitalization of $100 million. All issues are individually trader-priced
monthly.
 
    (f) CS First Boston Upper/Middle Tier High Yield Index -- an unmanaged index
of bonds rated B to BBB.
 
    38
<PAGE>
    (g) Goldman Sachs 100 Convertible Bond Index -- currently includes 67 bonds
and 33 preferred. The original list of names was generated by screening for
convertible issues of 100 million or greater in market capitalization. The index
is priced monthly.
 
    (h) GPR Life European Real Estate T.R. Index -- a European market
capitalization weighted index of listed property/ real estate securities
measuring total return.
 
    (i) GPR Life Far East Asia Real Estate T.R. Index -- a Far East market
capitalization weighted index of listed property/ real estate securities
measuring total return.
 
    (j)  Hambrecht and Quist Technology Index -- an index of computer and chip
makers, biotechnology concerns and other high-tech companies.
 
    (k) IFC Global Total Return Composite Index -- an unmanaged index of common
stocks and includes 18 developing countries in Latin America, East and South
Asia, Europe, the Middle East and Africa (net of dividends reinvested).
 
    (l) Indata Balanced-Median Index -- an unmanaged index and includes an asset
allocation of 0.5% cash, 37.9% bonds and 61.6% equity based on $52.5 billion in
assets among 431 portfolios for the year ended December 31, 1997 (assumes
dividends reinvested).
 
    (m) Indata Equity-Median Stock Index -- an unmanaged index which includes an
average asset allocation of 8.3% cash and 91.7% equity based on $491.5 billion
in assets among 979 portfolios for the year ended December 31, 1997.
 
    (n) J.P. Morgan Emerging Markets Bond Index -- a market-weighted index
composed of all Brady bonds outstanding and includes Argentina, Brazil,
Bulgaria, Mexico, Nigeria, the Philippines, Poland and Venezuela.
 
    (o) J.P. Morgan Emerging Markets Bond Plus Index -- expanding on the J.P.
Morgan Emerging Markets Bond Index, which only trades Brady Bonds, this index
reflects total returns for external debt instruments which have been traded in
emerging markets. Brady Bonds are included among such instruments, as well as
Eurobonds, loans and U.S. dollar denominated local market instruments. Countries
included in the index are Argentina, Brazil, Bulgaria, Ecuador, Mexico, Morocco,
Nigeria, Panama, Peru, the Phillipines, Poland, Russia, South Africa and
Venezuela. A more comprehensive benchmark than the EMBI, the EMBI+ covers 49
instruments from these countries. At $96 billion, its market cap is nearly 50%
higher than the EMBI's. The EMBI+ is not, however, intended to replace the EMBI
but rather to complement it. The EMBI continues to represent the most liquid,
most easily traded segment of the market, including more of the assets that
investors typically hold in their portfolios. Both of these indices are
published daily.
 
    (p) J.P. Morgan Traded Global Bond Index -- an unmanaged index of securities
and includes Australia, Belgium, Canada, Denmark, France, Germany, Italy, Japan,
The Netherlands, Spain, Sweden, United Kingdom and the United States.
 
    (q) Lehman Brothers Aggregate Bond Index -- an unmanaged index made up of
the Government/Corporate Index, the Mortgage Backed Securities Index and the
Asset-Backed Securities Index.
 
    (r) Lehman Brothers LONG-TERM Treasury Bond Index -- composed of all bonds
covered by the Lehman Brothers Treasury Bond Index with maturities of 10 years
or greater.
 
    (s) The Lehman 7 Year Municipal Bond Index -- an unmanaged index which
consists of investment grade bonds with maturities between 6-8 years rated BAA
or better. All bonds have been taken from deals done within the last 5 years,
with assets of $50 million or larger.
 
    (t) Lipper Capital Appreciation Index -- a composite of mutual funds managed
for maximum capital gains.
 
    (u) Lipper Science and Technology Fund Index -- a composite index of the
mutual funds which invest at least 65% of their assets in science and technology
stocks.
 
    (v) Morgan Stanley Capital International Combined Far East Free ex-Japan
Index -- a market-capitalization weighted index comprising stocks in China Free
Hong Kong, Indonesia, Korea, Malaysia, Philippines, Singapore, Taiwan and
Thailand. Korea is included in the MSCI Combined Far East Free ex-Japan Index at
20% of its market capitalization.
 
    (w) Morgan Stanley Capital International EAFE Index -- an arithmetic, market
value-weighted average of the performance of over 1,000 securities on the stock
exchanges of countries in Europe, Australia, New Zealand and the Far East.
 
    (x) Morgan Stanley Capital International EAFE Small Cap Index -- an
arithmetic, unmanaged, market value-weighted average of the performance of all
companies in Europe, Australia and the Far East with a market capitalization of
U.S. $200 million -- $800 million.
 
    (y) Morgan Stanley Capital International Emerging Markets Free Index -- a
market capitalization weighted equity index composed of companies that are
representative of the market structure of the following countries: Argentina,
Brazil, Chile, China Free, Colombia, Czech Republic, Greece, Hungary, India,
Indonesia, Israel, Jordan, Korea (at 50%), Malaysia, Mexico Free, Pakistan,
Peru, Philippines Free, Poland, Portugal, Russia, South Africa, Sri Lanka,
Taiwan (at 50%), Thailand, Turkey,
 
                                                                          39
<PAGE>
Venezuela Free. The base date for the index is December 31, 1987. "Free" MSCI
indices excludes those shares which are not purchasable by foreign investors.
The average size of the emerging market companies within this index is U.S. $800
million.
 
    (z) Morgan Stanley Capital International Emerging Markets Global Latin
America Index -- an unmanaged, arithmetic market value weighted average of the
performance of over 196 securities on the stock exchanges of Argentina, Brazil,
Chile, Colombia, Mexico, Peru and Venezuela (Assumes reinvestment of dividends).
 
    (aa) Morgan Stanley Capital International Europe Index -- an unmanaged index
of common stocks and includes 14 countries throughout Europe.
 
    (bb) Morgan Stanley Capital International Japan Index -- an unmanaged index
of common stocks (assumes dividends reinvested).
 
    (cc) Morgan Stanley Capital International Latin America Index -- a
broad-based market capitalization-weighted composite index covering at least 60%
of markets in Mexico, Argentina, Brazil, Chile, Colombia, Peru and Venezuela
(assumes dividends reinvested).
 
    (dd) Morgan Stanley Capital International World Index -- an arithmetic,
market value-weighted average of the performance of over 1,470 securities listed
on the stock exchanges of countries in Europe, Australia, the Far East, Canada
and the United States.
 
    (ee)  Morgan Stanley High Tech 35 Index -- an index comprised of thirty-five
technology stocks chosen by Morgan Stanley.
 
    (ff) NASDAQ Composite Index -- an unmanaged index of common stocks.
 
    (gg) NASDAQ Industrial Index -- a capitalization-weighted index composed of
more than 3,000 domestic stocks taken from the following industry sectors:
agriculture, mining, construction, manufacturing, electronic components,
services and public administration enterprises. It is a value-weighted index
calculated on price change only and does not include income.
 
    (hh) National Association of Real Estate Investment Trusts ("NAREIT") Index
- -- an unmanaged market weighted index of tax qualified REITs (excluding
healthcare REITs) listed on the New York Stock Exchange, American Stock Exchange
and the NASDAQ National Market System including dividends.
 
    (ii) The New York Stock Exchange composite or component indices -- unmanaged
indices of all industrial, utilities, transportation and finance company stocks
listed on the New York Stock Exchange.
 
    (jj)  Pacific Stock Exchange Index -- an index consisting of approximately
100 technology and healthcare technology concerns.
 
    (kk) Philadelphia Gold and Silver Index -- an unmanaged index comprised of
seven leading companies involved in the mining of gold and silver.
 
    (ll) Russell 2000 Growth Index -- comprised of those Russell 2000 Securities
with an above-average growth orientation. Here, securities tend to exhibit
higher price-to-book and price-earnings ratios, lower divided yields and higher
forecasted growth than the Value universe.
 
    (mm)Russell 2500 Index -- comprised of the bottom 500 stocks in the Russell
1000 Index which represents the universe of stocks from which most active money
managers typically select; and all the stocks in the Russell 2000 Index. The
largest security in the index has a market capitalization of approximately 1.3
billion.
 
    (nn) Salomon Smith Barney GNMA Index -- includes pools of mortgages
originated by private lenders and guaranteed by the mortgage pools of the
Government National Association.
 
    (oo) Salomon Smith Barney High Grade Corporate Bond Index -- consists of
publicly issued, non-convertible corporate bonds rated AA or AAA. It a is
value-weighted, total return index, including approximately 800 issues with
maturities of 12 years or greater.
 
    (pp) Salomon Smith Barney Broad Investment Grade Bond -- a market-weighted
index that contains approximately 4700 individually priced investment grade
corporate bonds rated BBB or better, U.S. Treasury/agency issues and mortgage
pass-through securities.
 
    (qq)  Sound View Technology Index -- an unweighted index consisting of more
than 100 technology companies.
 
    (rr) Standard & Poor's 500 Stock Index or its component indices -- unmanaged
index composed of 400 industrial stocks, 40 financial stocks, 40 utilities
company stocks and 20 transportation stocks. Comparisons of performance assume
reinvestment of dividends.
 
    (ss) Standard & Poor's Small Cap 600 Index -- a capitalization-weighted
index of 600 domestic stocks having market capitalizations which reside within
the 50th and the 83rd percentiles of the market capitalization of the entire
stock market, chosen for certain liquidity characteristics and for industry
representation.
 
    40
<PAGE>
    (tt) Wilshire 5000 Equity Index or its component indices -- represents the
return on the market value of all common equity securities for which daily
pricing is available. Comparisons of performance assume reinvestment of
dividends.
 
    In assessing such comparisons of performance an investor should keep in mind
that the composition of the investments in the reported indices and averages is
not identical to the composition of investments in the Fund's Portfolios, that
the averages are generally unmanaged, and that the items included in the
calculations of such averages may not be identical to the formula used by the
Fund to calculate its futures. In addition, there can be no assurance that the
Fund will continue this performance as compared to such other averages.
 
GENERAL PERFORMANCE INFORMATION
 
    Each Portfolio's performance will fluctuate, unlike bank deposits or other
investments which pay a fixed yield for a stated period of time. Past
performance is not necessarily indicative of future return. Actual performance
will depend on such variables as portfolio quality, average portfolio maturity,
the type of portfolio instruments acquired, changes in interest rates, portfolio
expenses and other factors. Performance is one basis investors may use to
analyze a Portfolio as compared to other funds and other investment vehicles.
However, performance of other funds and other investment vehicles may not be
comparable because of the foregoing variables, and differences in the methods
used in valuing their portfolio instruments, computing net asset value and
determining performance.
 
    From time to time, a Portfolio's performance may be compared to other mutual
funds tracked by financial or business publications and periodicals. For
example, a Portfolio may quote Morningstar, Inc. in its advertising materials.
Morningstar, Inc. is a mutual fund rating service that rates mutual funds on the
basis of risk-adjusted performance. Rankings that compare the performance of the
Funds to one another in appropriate categories over specific periods of time may
also be quoted in advertising.
 
    Portfolio advertising may include data on historical returns of the capital
markets in the United States compiled or published by Ibbotson Associates of
Chicago, Illinois ("Ibbotson"), including returns on common stocks, small
capitalization stocks, long-term corporate bonds, intermediate-term government
bonds, long-term government bonds, Treasury bills, the U.S. rate of inflation
(based on the Consumer Price Index), and combinations of various capital
markets. The performance of these capital markets is based on the returns of
different indices. The Portfolios may use the performance of these capital
markets in order to demonstrate general risk-versus-reward investment scenarios.
Performance comparisons may also include the value of a hypothetical investment
in any of these capital markets. The risks associated with the security types in
any capital market may or may not correspond directly to those of the
Portfolios. The Portfolios may also compare their performance to that of other
compilations or indices that may be developed and made available in the future.
 
    The Portfolios may include in advertisements, charts, graphs or drawings
which illustrate the potential risks and rewards of investment in various
investment vehicles, including but not limited to, foreign securities, stocks,
bonds, treasury bills and shares of a Portfolio. In addition, advertisements may
include a discussion of certain attributes or benefits to be derived by an
investment in a Portfolio and/or other mutual funds, shareholder profiles and
hypothetical investor scenarios, timely information on financial management, tax
and retirement planning and various investment alternatives. Advertisements may
include lists of representative Morgan Stanley clients. The Portfolios may also
from time to time include discussions or illustrations of the effects of
compounding in advertisements. "Compounding" refers to the fact that, if
dividends or other distributions on a Portfolio investment are reinvested by
being paid in additional Portfolio shares, any future income or capital
appreciation of a Portfolio would increase the value, not only of the original
investment in the Portfolio, but also of the additional Portfolio shares
received through reinvestment.
 
    The Portfolios may include in its advertisements, discussions or
illustrations of the potential investment goals of a prospective investor
(including materials that describe general principles of investing, such as
asset allocation, diversification, risk tolerance, goal setting, questionnaires
designed to help create a personal financial profile, worksheets used to project
savings needs based on assumed rates of inflation and hypothetical rates of
return and action plans offering investment alternatives), investment management
techniques, policies or investment suitability of a Portfolio (such as value
investing, market timing, dollar cost averaging, asset allocation, constant
ratio transfer, automatic account rebalancing, the advantages and disadvantages
of investing in tax-deferred and taxable investments). Advertisements and sales
materials relating to a Portfolio may include information regarding the
background and experience of its portfolio managers; the resources, expertise
and support made available to the portfolio managers by Morgan Stanley; and the
portfolio manager's goals, strategies and investment techniques.
 
    The Portfolios' advertisements may discuss economic and political conditions
of the United States and foreign countries, the relationship between sectors of
the U.S., a foreign, or the global economy and the U.S., a foreign, or the
global economy as a whole and the effects of inflation. The Portfolios may
include discussions and illustrations of the growth potential of various global
markets including, but not limited to, Africa, Asia, Europe, Latin America,
North America, South America, Emerging Markets and individual countries. These
discussions may include the past performance of the various markets or market
sectors; forecasts of population, gross national product and market performance;
and the underlying data which supports such forecasts. From time to time,
advertisements, sales literature, communications to shareholders or other
materials may
 
                                                                          41
<PAGE>
summarize the substance of information contained in the Portfolios' shareholder
reports (including the investment composition of a Portfolio), as well as the
views of Morgan Stanley as to current market, economic, trade and interest rate
trends, legislative, regulatory and monetary developments, investment strategies
and related matters believed to be of relevance to a Portfolio.
 
    The Portfolios may quote various measures of volatility and benchmark
correlation in advertising. The Portfolios may compare these measures to those
of other funds. Measures of volatility seek to compare the historical share
price fluctuations or total returns to those of a benchmark. Measures of
benchmark correlation indicate how valid a comparative benchmark may be.
Measures of volatility and correlation may be calculated using averages of
historical data. A Portfolio may also advertise its current interest rate
sensitivity, duration, weighted average maturity or similar maturity
characteristics.
 
    The Portfolio may advertise examples of the effects of periodic investment
plans, including the principle of dollar cost averaging. In such a program, an
investor invests a fixed dollar amount in a Portfolio at periodic intervals,
thereby purchasing fewer shares when prices are high and more shares when prices
are low. While such a strategy does not assure a profit or guard against loss in
a declining market, the investor's average cost per share can be lower than if
fixed numbers of shares are purchased at the same intervals. In evaluating such
a plan, investors should consider their ability to continue purchasing shares
during periods of low price levels.
 
                              GENERAL INFORMATION
 
DESCRIPTION OF SHARES AND VOTING RIGHTS
 
    The Fund's Articles of Incorporation, as amended and restated, permit the
Directors to issue 40 billion shares of common stock, par value $.001 per share,
from an unlimited number of classes ("Portfolios") of shares. Currently the Fund
consists of shares of thirty-two Portfolios (the China Growth, Mortgage-Backed
Securities and MicroCap Portfolios are not currently offering shares).
 
    The shares of each Portfolio of the Fund are fully paid and nonassessable,
and have no preference as to conversion, exchange, dividends, retirement or
other features. The shares of each Portfolio of the Fund have no pre-emptive
rights. The shares of the Fund have non-cumulative voting rights, which means
that the holders of more than 50% of the shares voting for the election of
Directors can elect 100% of the Directors if they choose to do so. A shareholder
is entitled to one vote for each full share held (and a fractional vote for each
fractional share held), then standing in his name on the books of the Fund.
 
DIVIDENDS AND CAPITAL GAINS DISTRIBUTIONS
 
    The Fund's policy is to distribute substantially all of each Portfolio's net
investment income, if any. The Fund may also distribute any net realized capital
gains in the amount and at the times that will avoid both income (including
taxable gains) taxes on it and the imposition of the federal excise tax on
income and capital gains (see discussion under "Taxes" in this Statement of
Additional Information). However, the Fund may also choose to retain net
realized capital gains and pay taxes on such gains. The amounts of any income
dividends or capital gains distributions cannot be predicted.
 
    Any dividend or distribution paid shortly after the purchase of shares of a
Portfolio by an investor may have the effect of reducing the per share net asset
value of that Portfolio by the per share amount of the dividend or distribution.
Furthermore, such dividends or distributions, although in effect a return of
capital, are subject to income taxes for shareholders subject to tax as set
forth herein and in the applicable Prospectus.
 
    As set forth in the Prospectuses, unless the shareholder elects otherwise in
writing, all dividends and capital gains distributions for a class of shares are
automatically received in additional shares of such class of that Portfolio of
the Fund at net asset value (as of the business day following the record date).
This automatic reinvestment of dividends and distributions will remain in effect
until the Fund is notified by the shareholder in writing at least three days
prior to the record date that either the Income Option (income dividends in cash
and capital gains distributions in additional shares at net asset value) or the
Cash Option (both income dividends and capital gains distributions in cash) has
been elected.
 
    LOCAL ADMINISTRATORS FOR THE EMERGING MARKETS PORTFOLIO.  The Portfolio has,
as required by local law, entered into administration agreements with local
administrators in Brazil and Colombia. A local administrator provides certain
services for the Portfolio with respect to the Portfolio's investments in that
country, including services relating to foreign exchange, local taxes,
remittance of income and capital gains, and repatriation of investments. The
Portfolio's local administrator in Brazil, Unibanco-Uniao, a Brazilian
corporation, is paid by an annual fee of 0.125% of the Portfolio's average
weekly net assets invested in Brazil. The Portfolio's local administrator in
Colombia, CitiTrust S.A., a Colombian trust company, is paid by the Fund an
annual fee of $1,000 plus 0.20% per transaction in Colombia.
 
    LOCAL ADMINISTRATORS FOR THE LATIN AMERICAN PORTFOLIO.  The Portfolio has,
as required by local law, entered into administration agreements with local
administrators in Brazil, Chile, and Colombia. A local administrator provides
certain services for the Portfolio with respect to the Portfolio's investments
in that country, including services relating to foreign exchange, local taxes,
remittance of income and capital gains, and repatriation of investments. The
Portfolio's local administrator in Brazil, Unibanco-Uniao, a Brazilian
corporation, is paid by the Fund an annual fee of 0.125% of the Portfolio's
average weekly net
 
    42
<PAGE>
assets invested in Brazil. The Portfolio's local administrator in Chile, Bice
Chileconsult Agente de Valores S.A., a Chilean corporation, is paid by the Fund
an annual fee of 0.125% of the Portfolio's average weekly net assets invested in
Chile. The Portfolio's local administrator in Colombia, CitiTrust S.A., a
Colombian trust company, is paid by the Fund an annual fee of $1,000 plus 0.20%
per transaction in Colombia.
 
CUSTODY ARRANGEMENTS
 
    Chase is the Fund's custodian for domestic and certain foreign assets. Chase
is not affiliated with the Adviser or Morgan Stanley. Morgan Stanley Trust
Company, Brooklyn, NY, acts as the Fund's custodian for foreign assets held
outside the United States and employs subcustodians who were approved by the
Directors of the Fund in accordance with Rule 17f-5 adopted by the Commission
under the 1940 Act. Morgan Stanley Trust Company is an affiliate of the Adviser
and Morgan Stanley. In the selection of foreign subcustodians, the Directors
consider a number of factors, including, but not limited to, the reliability and
financial stability of the institution, the ability of the institution to
provide efficiently the custodial services required for the Fund, and the
reputation of the institution in the particular country or region.
 
FUND COUNSEL
 
    Morgan, Lewis & Bockius LLP acts as the Fund's legal counsel.
 
INDEPENDENT ACCOUNTANTS
 
    Price Waterhouse LLP serves as independent accountants for the Fund and
audits the annual financial statements of each Portfolio.
 
ADVISER'S USE OF COMPANIES COMPRISING THE S&P 500 INDEX
 
    The Adviser uses the 500 companies included in the S&P 500 Index as the
universe of potential investments for the U.S. Equity Plus Portfolio. The U.S.
Equity Plus Portfolio is not sponsored, endorsed, sold or promoted by Standard &
Poor's ("S&P"), a division of The McGraw-Hill Companies, Inc. S&P makes no
representation or warranty, express or implied, to investors in the U.S. Equity
Plus Portfolio or any member of the public regarding the advisability of
investing in the U.S. Equity Plus Portfolio or the ability of the S&P 500 Index
to track general stock market performance. S&P's only relationship to the
Adviser is the licensing of certain trademarks and trade names of S&P and of the
S&P 500 Index which is determined, composed and calculated by S&P without regard
to the Adviser or the U.S. Equity Plus Portfolio. S&P has no obligation to take
the needs of the Adviser or the investors in the U.S. Equity Plus Portfolio into
consideration in determining, composing or calculating the S&P 500 Index. S&P is
not responsible for, does not participate in and has no obligation or liability
in connection with the management, administration or marketing of the U.S.
Equity Plus Portfolio.
 
    S&P DOES NOT GUARANTEE THE ACCURACY AND/OR COMPLETENESS OF THE S&P 500 INDEX
OR ANY DATA INCLUDED THEREIN AND S&P SHALL HAVE NO LIABILITY FOR ANY ERRORS,
OMISSIONS OR INTERRUPTIONS THEREIN. S&P MAKES NO WARRANTY, EXPRESS OR IMPLIED,
AS TO THE PERFORMANCE OF THE ADVISER OR THE U.S. EQUITY PLUS PORTFOLIO, AND
EXPRESSLY DISCLAIMS ALL WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A
PARTICULAR PURPOSE OR USE WITH RESPECT TO THE S&P 500 INDEX OR ANY DATA INCLUDED
THEREIN. WITHOUT LIMITING ANY OF THE FOREGOING, IN NO EVENT SHALL S&P HAVE ANY
LIABILITY FOR ANY SPECIAL, PUNITIVE, INDIRECT, OR CONSEQUENTIAL DAMAGES
(INCLUDING LOST PROFITS) ARISING OUT OF ANY USE OF THE S&P 500 INDEX OR ANY DATA
INCLUDED THEREIN, EVEN IF NOTIFIED OF THE POSSIBILITY OF SUCH DAMAGES.
 
                             DESCRIPTION OF RATINGS
 
DESCRIPTION OF COMMERCIAL PAPER AND BOND RATINGS
 
    EXCERPTS FROM MOODY'S INVESTORS SERVICE, INC. ("MOODY'S") DESCRIPTION OF
BOND RATINGS:  Aaa -- Bonds which are rated Aaa are judged to be of the best
quality. They carry the smallest degree of investment risk and are generally
referred to as "gilt-edged." Interest payments are protected by a large or by an
exceptionally stable margin and principal is secure. While the various
protective elements are likely to change, such changes as can be visualized are
most unlikely to impair the fundamentally strong position of such issues. Aa --
Bonds which are rated Aa are judged to be of high quality by all standards.
Together with the Aaa group they comprise what are generally known as high-grade
bonds. They are rated lower than the best bonds because margins of protection
may not be as large as in Aaa securities or fluctuation of protective elements
may be of greater amplitude or there may be other elements present which make
the long-term risks appear somewhat larger than Aaa securities. A -- Bonds which
are rated A possess many favorable investment attributes and are to be
considered as upper-medium-grade obligations. Factors giving security to
principal and interest are considered adequate, but elements may be present
which suggest a susceptibility to impairment some time in the future. Baa --
Bonds which are rated Baa are considered as medium-grade obligations, i.e., they
are neither highly protected nor poorly secured. Interest payments and principal
security appear adequate for the present but certain protective elements may be
lacking or may be characteristically
 
                                                                          43
<PAGE>
unreliable over any great length of time. Such bonds lack outstanding investment
characteristics and in fact have speculative characteristics as well. Ba --
Bonds which are rated Ba are judged to have speculative elements; their future
cannot be considered as well assured. Often the protection of interest and
principal payments may be very moderate, and thereby not well safeguarded during
both good and bad times over the future. Uncertainty of position characterizes
bonds in this class. B -- Bonds which are rated B generally lack characteristics
of the desirable investment. Assurance of interest and principal payments or of
maintenance of other terms of the contract over any long period of time may be
small. Moody's applies numerical modifiers 1, 2 and 3 in each generic voting
classification from Aa through B. The modifier 1 indicates that the security
ranks at a higher end of the rating category; modifier 2 indicates a mid-range
rating; and the modifier 3 indicates that the issue ranks at the lower end of
the rating category. Caa -- Bonds which are rated Caa are of poor standing. Such
issues may be in default or there may be present elements of danger with respect
to principal or interest. Ca -- Bonds which are rated Ca represent obligations
which are speculative in a high degree. Such issues are often in default or have
other marked shortcomings. C -- Bonds which are rated C are the lowest rated
class of bonds, and issues so rated can be regarded as having extremely poor
prospects of ever attaining any real investment standing.
 
    EXCERPTS FROM S&P'S DESCRIPTION OF BOND RATINGS:  AAA -- Bonds rated AAA
have the highest rating assigned by Standard & Poor's to a debt obligation and
indicate an extremely strong capacity to pay principal and interest. AA -- Bonds
rated AA have a very strong capacity to pay interest and repay principal and
differ from the highest rated issues only to a small degree. A -- Bonds rated A
have a strong capacity to pay interest and repay principal although they are
somewhat more susceptible to the adverse effects of changes in circumstances and
economic conditions than bonds in higher rated categories. BBB -- Bonds rated
BBB are regarded as having an adequate capacity to pay interest and repay
principal. Whereas they normally exhibit adequate protection parameters, adverse
economic conditions or changing circumstances are more likely to lead to a
weakened capacity to pay interest and repay principal for debt in this category
than for debt in higher rated categories. BB, B, CCC, CC and C -- Debt rated BB,
B, CCC, CC and C is regarded, on balance, as predominantly speculative with
respect to
capacity to pay interest and repay principal in accordance with the terms of the
obligation. BB indicates the lowest degree of speculation and C the highest
degree of speculation. While such debt will likely have some quality and
protective characteristics, these are outweighed by large uncertainties or major
risk exposures to adverse conditions. C -- The rating C may be used to cover a
situation where a bankruptcy petition has been filed or similar action has been
taken, but payments on this obligation are being continued. D -- Debt rated D is
in default, and payment of interest and/or repayment of principal is in arrears.
 
    DESCRIPTION OF MOODY'S RATINGS OF STATE AND MUNICIPAL NOTES:  Moody's
ratings for state and municipal notes and other short-term obligations are
designated Moody's Investment Grade ("MIG"). Symbols used are as follows: MIG-1
- -- best quality, enjoying strong protection from established cash flows of funds
for their servicing or from established broad-based access to the market for
refinancing, or both; MIG-2 -- high quality with margins of protection ample
although not so large as in the preceding group; MIG-3 - favorable quality, with
all security elements accounted for but lacking the undeniable strength of the
preceding grades.
 
    DESCRIPTION OF MOODY'S HIGHEST COMMERCIAL PAPER RATING:  Prime-1 ("P1") --
Judged to be of the best quality. Their short-term debt obligations carry the
smallest degree of investment risk.
 
    EXCERPT FROM S&P'S RATING OF MUNICIPAL NOTE ISSUES:  SP-1+ -- very strong
capacity to pay principal and interest; SP-2 -- strong capacity to pay principal
and interest.
 
    DESCRIPTION OF S&P'S HIGHEST COMMERCIAL PAPER RATINGS:  A-1+ -- this
designation indicates the degree of safety regarding timely payment is extremely
strong. A-1 -- this designation indicates the degree of safety regarding timely
payment is strong.
 
                              FINANCIAL STATEMENTS
 
    The Fund's audited financial statements for the fiscal year ended December
31, 1997, including notes thereto and the report of Price Waterhouse LLP are
herein incorporated by reference from the Fund's Annual Report. A copy of the
Fund's Annual Report to Shareholders must accompany the delivery of this
Statement of Additional Information. The China Growth, Mortgage-Backed
Securities and MicroCap Portfolios had not commenced operations at December 31,
1997.
 
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