MORGAN STANLEY DEAN WITTER INSTITUTIONAL FUND INC
497, 2000-02-22
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                       SUPPLEMENT DATED FEBRUARY 22, 2000
           TO STATEMENT OF ADDITIONAL INFORMATION DATED MAY 1, 1999,
             AS AMENDED AND SUPPLEMENTED THROUGH DECEMBER 27, 1999

              MORGAN STANLEY DEAN WITTER INSTITUTIONAL FUND, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                   02208-2798

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    The Statement of Additional Information is being supplemented to reflect
that the Latin American Portfolio will invest at least 25%, but no more than
50%, of its total assets in companies involved in the telecommunications
industry or financial services industry. Accordingly, the last paragraph on page
24 is hereby deleted and replaced with the following:

    In accordance with fundamental investment limitation number (7), the Latin
    American Portfolio will invest at least 25%, but no more than 50%, of its
    total assets in companies involved in the telecommunications industry or
    financial services industry if the Board of Directors determines that the
    Latin American markets are dominated by securities of issuers in such
    industries and that, in light of the anticipated return, investment quality,
    availability and liquidity of the issuers in such industries, the
    Portfolio's ability to achieve its investment objective would, in light of
    the investment policies and limitations, be materially adversely affected if
    the Portfolio was not able to invest greater than 25% of its total assets in
    such industries. The Board of Directors has made the foregoing determination
    and, accordingly, the Latin American Portfolio will invest between 25% and
    50% of its assets in securities of issuers engaged in the telecommunications
    industry.

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               PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE


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