MORGAN STANLEY DEAN WITTER INSTITUTIONAL FUND INC
497, 2000-01-27
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                       SUPPLEMENT DATED JANUARY 27, 2000
                        TO PROSPECTUS DATED MAY 1, 1999

                                       OF

                           U.S. EQUITY PLUS PORTFOLIO

                                PORTFOLIO OF THE

              MORGAN STANLEY DEAN WITTER INSTITUTIONAL FUND, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                   02208-2798
                             ---------------------

    The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the U.S. Equity Plus Portfolio (the "Portfolio"). Eugene
Flood, Jr. no longer serves as a Portfolio Manager to the Portfolio. Narayan
Ramachandran, who previously shared primary responsibility with Mr. Flood, will
continue to have primary responsibility for managing the assets of the
Portfolio. Accordingly, the paragraph on page 6 is hereby deleted and replaced
with the following:

NARAYAN RAMACHANDRAN

Narayan Ramachandran is a Managing Director of MSDW Investment Management and
Morgan Stanley and is a Portfolio Manager and head of the Structured Asset
Management business at MSDW Investment Management. Prior to joining MSDW
Investment Management in 1996, he was Managing Director of RogersCasey
Associates, Inc. ("RogersCasey"), an investment consulting and special assets
advisory firm based in Darien, Connecticut. As President of RogersCasey's
investment advisory subsidiary, he was responsible for leading the special
assets advisory business with $2 billion in assets under management. Prior to
that, he was Director of Research for RogersCasey, with his research efforts
focused on quantitative investment models. He holds a B.S. in Chemical
Engineering from the Indian Institute of Technology in Bombay and an M.B.A. from
the University of Michigan at Ann Arbor. He is also a Chartered Financial
Analyst. Mr. Ramachandran has had primary responsibility for managing the
Portfolio's assets since its inception.

                            ------------------------

               PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE


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