COMMONWEALTH ASSOCIATES
SC 13D, 1996-10-24
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549


                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                           (Amendment No. _________)*


                           AccuMed International, Inc.
                                (Name of Issuer)

                           Common Stock, no par value
                         (Title of Class of Securities)

                                    010740108
                                 (CUSIP Number)

                                J.P. Wilson, Esq.
                                 General Counsel
                             Commonwealth Associates
             733 3rd Avenue, New York, New York 10017 (212) 297-5652
                 (Name, Address and Telephone Number of Person
                Authorized to Receive Notice and Communications)

                                October 12, 1993
             (Date of Event which Requires Filing of this Statement)


     If the filing person has previously filed a statement on Schedule 13G to
     report the acquisition which is the subject of this Schedule 13D, and is
     filing this schedule because of Rule 13d-1(b)(3) or (4), check the
     following box |_|.

     Check the following box if a fee is being paid with the statement|X|. (A
     fee is not required only if the reporting person: (1) has a previous
     statement on file reporting beneficial ownership of more than five percent
     of the class of securities described in Item 1; and (2) has filed no
     amendment subsequent thereto reporting beneficial ownership of five percent
     or less of such class.) (See Rule 13d-7).

     Note: Six copies of this statement, including all exhibits, should be filed
     with the Commission. See Rule 13d-1(a) for other parties to whom copies are
     to be sent.

*    The remainder of this cover page shall be filled out for a reporting
     person's initial filing on this form with respect to the subject class of
     securities, and for any subsequent amendment containing information which
     would alter disclosures provided in a prior cover page.

     The information required on the remainder of this cover page shall not be
     deemed to be "filed" for the purpose of Section 18 of the Securities
     Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
     that section of the Act but shall be subject to all other provisions of the
     Act (however, see the Notes).



                                Page 1 of 9 Pages

<PAGE>

                                  SCHEDULE 13D

CUSIP NO. 010740108                                          Page 2 of 10 Pages



- --------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       Michael S. Falk

- --------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [ ]
                                                             (b)  [X]

- --------------------------------------------------------------------------------
   3   SEC USE ONLY


- --------------------------------------------------------------------------------
   4   SOURCE OF FUNDS*

       OO

- --------------------------------------------------------------------------------
   5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
       ITEMS 2(d) OR 2(e)                                         [  ]


- --------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

       United States

- --------------------------------------------------------------------------------
                  7    SOLE VOTING POWER
                       807,631 (of which 585,409 shares of Common Stock are 
  NUMBER OF            issuable upon exercise of warrants)
                  --------------------------------------------------------------
   SHARES         8    SHARED VOTING POWER
BENEFICIALLY           2,696,931 (of which 2,252,931 shares of Common Stock
  OWNED BY             are issuable upon exercise of warrants)
                  --------------------------------------------------------------
    EACH          9    SOLE DISPOSITIVE POWER
 REPORTING             807,631  (of which  585,409  shares of Common  Stock are
   PERSON              issuable upon exercise of warrants)
                  --------------------------------------------------------------
    WITH          10   SHARED DISPOSITIVE POWER
                       2,696,931 (of which 2,252,487 shares of Common Stock
                       are issuable upon exercise of warrants)

- --------------------------------------------------------------------------------
  11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

       3,504,562 (of which 2,838,896 shares of Common Stock are issuable upon
       exercise of warrants)

- --------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [  ]

- --------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

       15.97%

- --------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON*

       IN

- --------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEM 1-7 (INCLUDING EXHIBITS)
OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.


                                Page 2 of 9 Pages

<PAGE>


                                  SCHEDULE 13D

CUSIP NO. 010740108                                          Page 3 of 10 Pages



- --------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       Commonwealth Associates Management Company, Inc.

- --------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [ ]
                                                             (b)  [X]

- --------------------------------------------------------------------------------
   3   SEC USE ONLY


- --------------------------------------------------------------------------------
   4   SOURCE OF FUNDS*

       AF

- --------------------------------------------------------------------------------
   5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
       ITEMS 2(d) OR 2(e)                                         [  ]


- --------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

       New York

- --------------------------------------------------------------------------------
                  7    SOLE VOTING POWER
                       1,889,300 (of which 1,667,078 shares of Common Stock are 
  NUMBER OF            issuable upon exercise of warrants)
                  --------------------------------------------------------------
   SHARES         8    SHARED VOTING POWER
BENEFICIALLY           0
  OWNED BY             
                  --------------------------------------------------------------
    EACH          9    SOLE DISPOSITIVE POWER
 REPORTING             1,889,300 (of which 1,667,078 shares of Common Stock are 
   PERSON              issuable upon exercise of warrants)
                  --------------------------------------------------------------
    WITH          10   SHARED DISPOSITIVE POWER
                       0

- --------------------------------------------------------------------------------
  11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

       1,889,300 (of which 1,667,078 shares of Common Stock are issuable upon 
       exercise of warrants)

- --------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [  ]

- --------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

       8.61%


- --------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON*

       CO

- --------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEM 1-7 (INCLUDING EXHIBITS)
OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.


                                Page 3 of 9 Pages

<PAGE>


                                  SCHEDULE 13D

CUSIP NO. 010740108                                          Page 4 of 10 Pages



- --------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       Commonwealth Associates

- --------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [ ]
                                                             (b)  [X]

- --------------------------------------------------------------------------------
   3   SEC USE ONLY


- --------------------------------------------------------------------------------
   4   SOURCE OF FUNDS*

       WC, OO

- --------------------------------------------------------------------------------
   5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
       ITEMS 2(d) OR 2(e)                                         [  ]


- --------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

       New York

- --------------------------------------------------------------------------------
                  7    SOLE VOTING POWER
                       1,889,300 (of which 1,667,078 shares of Common Stock are 
  NUMBER OF            issuable upon exercise of warrants)
                  --------------------------------------------------------------
   SHARES         8    SHARED VOTING POWER
BENEFICIALLY           0
  OWNED BY             
                  --------------------------------------------------------------
    EACH          9    SOLE DISPOSITIVE POWER
 REPORTING             1,889,300 (of which 1,667,078 shares of Common Stock are 
   PERSON              issuable upon exercise of warrants)
                  --------------------------------------------------------------
    WITH          10   SHARED DISPOSITIVE POWER
                       0

- --------------------------------------------------------------------------------
  11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

       1,889,300 (of which 1,667,078 shares of Common Stock are issuable upon 
       exercise of warrants)

- --------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [  ]

- --------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

       8.61%


- --------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON*

       BD, PN

- --------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEM 1-7 (INCLUDING EXHIBITS)
OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.


                                Page 4 of 9 Pages

<PAGE>


Item 1.     Security and Issuer.

            This  Schedule  relates to the Common Stock,  no par value  ("Common
Stock"),  issued by AccuMed  International,  Inc. a California  corporation (the
"Company"), whose principal executive offices are located at 900 North Franklin,
Suite 401, Chicago, IL 60610.

Item 2.     Identity and Background.

            This Schedule is filed by: (i) Commonwealth Associates ("CA"), a New
York limited  partnership,  which is registered as a broker/dealer under Section
15 of the  Securities  Exchange  Act of  1934,  as  amended;  (ii)  Commonwealth
Associates  Management Company,  Inc., a New York corporation  ("CAMCI") and the
sole general  partner of CA; and (iii) Michael S. Falk  ("Falk"),  president,  a
director  and  majority  stockholder  of  CAMCI  (CA,  CAMCI  and  Falk are each
hereinafter  sometimes  referred to as a "Reporting  Person" and collectively as
the  "Reporting  Persons").  The  address  of the  Reporting  Persons is 733 3rd
Avenue, New York, New York 10017. Falk is a United States citizen.

            During the last five (5) years,  none of the  Reporting  Persons has
been: (i) convicted in a criminal  proceeding  (excluding  traffic violations or
similar  misdemeanors),  or (ii) a party to a civil  proceeding of a judicial or
administrative body of competent jurisdiction and as a result of such proceeding
was or is  subject  to a  judgment,  decree  or  final  order  enjoining  future
violations  of, or prohibiting  or mandating  activities  subject to, federal or
state securities laws or finding any violations with respect to such laws.

Item 3.     Source and Amount of Funds or Other Consideration.

            Falk  acquired  redeemable  warrants to purchase 10 shares of Common
Stock, as components of units consisting of Common Stock and redeemable warrants
of the Company at a price of $5.50 per unit in March 1993, using personal funds.
A trust for the benefit of a minor child of Falk,  of which Falk's spouse is the
sole  trustee,  acquired  1,000  shares of Common Stock in April 1994 in an open
market  transaction at $1.25 per share using funds constituting a portion of the
principal of the trust.  In December  1994 the Company  issued to each of CA and
Falk,  warrants to purchase 320,000 and 80,000 shares,  respectively,  of Common
Stock,  exercisable  at any time until December 31, 1999 at a price of $0.25 per
share.  Such warrants  were issued to CA and Falk  partially to reimburse CA for
certain  expenses  it  incurred  in  connection  with  a  proposed  offering  of
Securities  of the  Company  in  1994  that  was  not  consummated  and  also in
consideration of the cancellation of certain Underwriter's Warrants issued to CA
and certain of its designees, including Falk (such Warrants consisting of Common
Stock and a  redeemable  warrant to  purchase  one share of Common  Stock).  The
Underwriter's Warrants were


                                Page 5 of 9 Pages

<PAGE>


issued to CA (and its designees) in consideration for services rendered by CA as
underwriter of the Company's  initial public offering of Common Stock in October
1992. The Company issued to each of CA, Falk and his wife,  warrants to purchase
17,427 and has 211,376 shares, respectively, of Common Stock, exercisable at any
time until May 9, 2000 at a price of $0.625 per share. Such warrants were issued
to CA and certain of its designees, including Falk and his wife in consideration
for services  rendered by CA as  placement  agent in  connection  with a private
offering of  securities  by the Company that was  consummated  in May 1995.  The
Company  has also  issued to CA and Falk,  as a  designee  of CA,  for  services
rendered by CA in August 1995 as placement agent for certain  private  offerings
of securities of the Company (i) warrants to purchase 33,196 and 184,871 shares,
respectively;  of Common Stock  exercisable at any time until August 18, 2000 at
$0.625 per share and (ii) warrants to purchase 3,648 and 34,161 shares of Common
Stock, respectively, exercisable at any time until August 22, 2000 at $0.625 per
share.  In  connection  with the December 29, 1995 merger  ("Merger") of AccuMed
International, Inc. into the Company, CA was paid a fee for acting as a "finder"
in connection  with the Merger.  The fee consisted of $50,000 paid in cash,  the
issuance of 444,444 shares of Common Stock (the "Merger Shares") and a five-year
warrant (the "Merger  Warrants") to purchase  750,000 shares of the Common Stock
at an exercise of $1.25 per share.  CA has  distributed  to Falk  222,222 of the
Merger  Shares and 175,000 of the Merger  Warrants.  The 2,673  shares of Common
Stock and redeemable warrants to purchase 980,840 shares of Common Stock held by
CA in its investment and trading  accounts as of May 31, 1996,  were acquired by
CA from  time  to  time  in open  market  transactions  at  varying  prices  for
investment  or in the ordinary  course of its market  making  activities,  using
working capital funds.  The warrants held in such account are exercisable at any
time until October 14, 1997 at $5.00 per share.

Item 4.     Purpose of Transaction.

            The  purpose  of the  acquisition  of  shares  of  Common  Stock and
warrants  to  purchase  Common  Stock by each of the  Reporting  Persons  is for
investment,  except for shares of Common  Stock  acquired  by CA and held in its
trading  account.  Securities held in the trading account were acquired by CA in
open market transactions in the ordinary course of its market making activities.

            The Reporting Persons may, for investment  purposes,  make purchases
of Common Stock and warrants to purchase  Common Stock from time to time and may
dispose of any or all of the shares of Common Stock and warrants held by them at
any time. CA may also acquire or dispose of shares of Comon Stock and redeemable
warrants to purchase Common Stock in the course of its market making activities.
The  Reporting  Persons  have no plans or  proposals  which  relate to, or could
result in, any of the matters  referred to in Paragraphs (b) through (j) of Item
4 of Schedule


                                Page 6 of 9 Pages

<PAGE>



13D, except that,  pursuant to the Agreement and Plan of  Reorganization,  dated
April 21, 1995,  entered into in connection with the Merger,  CA was granted the
right to appoint  with a third party three (3) members of the Board of Directors
and has exercised its right,  pursuant thereto. The Reporting Persons may review
or reconsider  their position with respect to the Company or formulate  plans or
proposals  with  respect to any such  matter,  but have no present  intention of
doing so.

Item 5.     Interest in Securities of the Issuer.

            As of May 31, 1996, CA beneficially  owned an aggregate of 1,889,300
shares of Common  Stock  (including  common  stock  issuable  upon  exercise  of
warrants),  constituting  approximately  10.05% of the outstanding Common Stock;
CAMCI  beneficially  owned an  aggregate  of  1,889,300  shares of Common  Stock
(attributing  all of the  shares  owned or deemed  to be owned by CA to  CAMCI),
constituting  approximately  10.05% of the  outstanding  Common Stock;  and Falk
beneficially  owned an aggregate of 3,504,562  shares of common stock (including
2,837,896   shares  of  common  stock   issuable  upon  exercise  of  warrants),
constituting  approximately  19.48% of the outstanding Common Stock (attributing
all of the shares  deemed to be owned by CAMCI to Falk).  The  percentages  used
herein are calculated based upon the number of shares of Common Stock issued and
outstanding at June 19, 1996 as provided by the transfer agent for the Company's
Common  Stock.  Except for the shares  owned or deemed  owned by CA, as to which
CAMCI and Falk share voting and  dispositive  power,  the 1,000 shares of Common
Stock  held by the trust  for the  benefit  of Mr.  Falk's  minor  child and the
warrants to purchase  100,000 shares of Common Stock owned by his wife, Falk has
sole voting and dispositive power with respect to all the shares of Common Stock
to which this  Schedule  relates.  The  Reporting  Persons have not effected any
transactions  in shares of the Common Stock in the past 60 days,  except that CA
has effectuated  transactions in the Common Stock and redeemable warrants in the
ordinary course of its market making activities.

            No  person,  other  than the  Reporting  Persons,  has the  right to
receive or the power to direct receipt of dividends from, or the proceeds of the
sale of, Common Stock.

Item 6.     Contracts, Arrangements, Understandings or
            Relationships with Respect to Securities of the Issuer.

            Pursuant  to the Merger  Agreement  the number of  directors  of the
Company  has been set at seven,  of which CA and  American  Equities,  a foreign
broker/dealer,  have the joint right to appoint  three  director  until the next
shareholders' meeting, at present unscheduled.

            The  Company has granted CA and its  designees  certain  "piggyback"
and/or demand registration rights with respect to the


                                Page 7 of 9 Pages

<PAGE>


shares of Common Stock  issuable  upon  exercise of the Merger  Warrants and the
warrants issued in December 1994 and in connection with the private offerings of
securities that were consummated in May 1995 and August 1995.

            Other than as set forth above, there are no contracts, arrangements,
understandings  or relationships  with the Reporting Persons or any other person
with respect to the  securities of the Company,  including,  but not limited to,
transfer or voting of any other securities,  finders' fees, joint ventures, loan
or option  arrangements,  puts or calls,  guaranties  of profits,  divisions  of
profits or loss or the giving or withholding of proxies.


Item 7.     Material to be Filed as Exhibits.


Exhibit 2.0    Agreement of Merger and Plan of  Reorganization,  dated April 21,
               1995, between the Company and Almar BioSciences, Inc.

Exhibit 2.1    Amendment No. 1 to Agreement and Plan of Reorganization

Exhibit 2.2    Amendment No. 2 to Agreement and Plan of Reorganization

Exhibit 2.3    Agreement of Merger

Exhibit 2.4    Affiliate Agreement

Exhibit 2.5    Waiver Under Merger Agreement

Exhibit 2.6    Mutual Waiver

Exhibit 4.0    Warrant  Agreement,  dated December 31, 1994, between the Company
               and CA to purchase up to 420,000 shares of Common Stock issued by
               the Company to CA and its designee(s).

Exhibit 4.1    Warrant  Agreement,  dated December 28, 1995, between the Company
               and CA to purchase up to 750,000 shares of Common Stock issued by
               the Company to CA and/or its designee(s).

Exhibit 4.2    Warrant Agreement,  dated May 9, 1995, between the Company and CA
               to purchase up to 264,840  shares of Common  Stock  issued by the
               Company to CA and/or its designee(s).

Exhibit 4.3    Warrant Agreement, dated August 18, 1995, between the Company and
               CA to purchase up to 258,700 shares of Common Stock issued by the
               Company to CA and/or its designee(s).

Exhibit 4.4    Warrant Agreement, dated August 22, 1994, between the Company and
               CA to purchase up to 41,300  shares of Common Stock issued by the
               Company to CA and/or its designee(s).

Exhibit 99     Joint Filing Agreement among the Reporting Persons, dated October
               23, 1996.



                                Page 8 of 9 Pages

<PAGE>




                                   SIGNATURES


            After reasonable inquiry and to the best of his or its knowledge and
belief, each of the undersigned certifies that the information set forth in this
statement is true, complete and correct.

DATE: October 23, 1996
                                          /s/ Michael S. Falk
                                      --------------------------------
                                          Michael S. Falk


                                    COMMONWEALTH ASSOCIATES MANAGEMENT
                                      COMPANY, INC.


                                    By:   /s/ Michael S. Falk
                                       -------------------------------
                                          Michael S. Falk, President


                                    COMMONWEALTH ASSOCIATES
                                    By: Commonwealth Associates
                                          Management Company, Inc.,
                                          its General Partner



                                    By:   /s/ Michael S. Falk
                                       -------------------------------
                                          Michael S. Falk, President



                                Page 9 of 9 Pages





                     AGREEMENT AND PLAN OF REORGANIZATION


      This AGREEMENT AND PLAN OF  REORGANIZATION  (the  "Agreement") is made and
entered  into as of April 21, 1995 by and between  ALAMAR  BIOSCIENCES,  INC., a
California  corporation  ("Alamar") and ACCUMED,  INC., an Illinois  corporation
("AccuMed").

                                   RECITALS

      A. The Boards of Directors of AccuMed and Alamar believe that it is in the
best interests of each company and their  respective  shareholders  that AccuMed
and Alamar combine into a single company  through the merger of AccuMed with and
into Alamar (the  "Merger")  and, in  furtherance  thereof,  have  approved  the
Merger.

      B. Pursuant to the Merger,  among other things,  the outstanding shares of
Common Stock of AccuMed shall be converted into shares of Common Stock of Alamar
at the rate  determined  herein,  subject to the  forfeiture  by the  pre-merger
shareholders of AccuMed (the "AccuMed  Shareholders")  of certain of such shares
of  Common  Stock  of  Alamar  if  certain  performance  targets  are not met as
determined herein.

      C.  AccuMed  and  Alamar  desire  to  make  certain   representations  and
warranties and other agreements in connection with the Merger.

      D. The parties  intend,  by executing this  Agreement,  to adopt a plan of
reorganization within the meaning of Section 368 of the Internal Revenue Code of
1986, as amended (the "Code").

      NOW,   THEREFORE,   in  consideration  of  the  covenants,   promises  and
representations set forth herein, and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged,  the parties agree
as follows:


                                  ARTICLE I
                                  THE MERGER

      1.1 The Merger. At the Effective Time (as hereinafter defined) and subject
to and upon the  terms  and  conditions  of this  Agreement  and the  applicable
provisions  of the  Illinois  Business  Corporation  Act  of  1983,  as  amended
("Illinois  Law"),  and the  California  General  Corporation  Law,  as  amended
("California  Law"),  AccuMed shall be merged with and into Alamar, the separate
corporate  existence  of AccuMed  shall cease and Alamar  shall  continue as the
surviving  corporation.  Alamar as the surviving corporation after the Merger is
hereinafter sometimes referred to as the "Surviving Corporation".



<PAGE>



      1.2  Effective  Time.  Subject to the  provisions of this  Agreement,  the
parties  hereto shall cause the Merger to be consummated by filing the Agreement
of Merger of Alamar and AccuMed  substantially in the form of Exhibit A attached
hereto  (the  "Agreement  of  Merger")  with the  Secretary  of State of each of
Illinois and California,  in accordance with the relevant provisions of Illinois
Law and California  Law (the time of such filing being the "Effective  Time") as
soon as  practicable  on or after the  Closing  Date (as  herein  defined).  The
closing of the Merger (the "Closing")  shall take place at the offices of Katten
Muchin & Zavis at a time and date to be specified by the parties, which shall be
no later than the second  business day after the  satisfaction  or waiver of the
conditions  set forth in Article VIII, or at such other time,  date and location
as the parties hereto agree (the "Closing Date").

      1.3 Effect of the Merger.  At the Effective Time, the effect of the Merger
shall be as provided in this Agreement and the applicable provisions of Illinois
Law and California Law.  Without  limiting the generality of the foregoing,  and
subject thereto,  at the Effective Time, all the property,  rights,  privileges,
powers  and  franchises  of  AccuMed  and  Alamar  shall  vest in the  Surviving
Corporation,  and all debts,  liabilities and duties of AccuMed and Alamar shall
become the debts, liabilities and duties of the Surviving Corporation.

      1.4   Articles of Incorporation; Bylaws.

            (a) At the Effective Time, the Articles of  Incorporation of Alamar,
      as in  effect  immediately  prior  to the  Effective  Time,  shall  be the
      Articles of Incorporation of the Surviving Corporation.

            (b) At the  Effective  Time,  the  Bylaws  of  Alamar,  as in effect
      immediately  prior  to the  Effective  Time,  shall be the  Bylaws  of the
      Surviving Corporation.

      1.5 Directors and Officers. The directors and officers of AccuMed shall be
the initial  directors  and officers of the Surviving  Corporation,  until their
respective successors are duly elected or appointed and qualified. The Surviving
Corporation  will elect new  directors and new officers as per Sections 7.17 and
7.18 hereof.

      1.6 Effect on  Capital  Stock.  At the  Effective  Time,  by virtue of the
Merger and  without  any action on the part of AccuMed or the  holders of any of
the following securities:

            (a) Conversion of AccuMed Capital Stock. Each share of Common Stock,
      no par value, of AccuMed  ("AccuMed Capital Stock") issued and outstanding
      immediately prior to the Effective Time will be cancelled and extinguished
      and will be converted automatically into the right to receive its pro rata
      portion of  5,750,000  shares of Common  Stock,  no par  value,  of Alamar
      ("Alamar  Common  Stock").  Each share of AccuMed  Capital  Stock shall be
      cancelled and converted as set forth in this Section 1.6(a) upon surrender
      of the certificate representing such share of AccuMed Capital Stock in the
      manner  provided  in  Section  1.7 (or in the  case of a lost,  stolen  or
      destroyed  certificate,  upon  delivery  of an  affidavit  (and  bond,  if
      required) in the manner provided in Section 1.9).


                                  -2-

<PAGE>


            (b)  Adjustments to Exchange  Ratio.  The number of shares of Alamar
      Common Stock into which each share of AccuMed  Common Stock shall  convert
      pursuant to this  Article I shall be adjusted to reflect  fully the effect
      of any split,  reverse stock split, stock dividend (including any dividend
      or  distribution  of  securities  convertible  into Alamar Common Stock or
      AccuMed Capital  Stock),  reorganization,  recapitalization  or other like
      change  with  respect  to Alamar  Common  Stock or AccuMed  Capital  Stock
      occurring  after the date hereof and prior to the Effective  Time,  except
      for the issuance of any shares of Alamar  Common  Stock  pursuant to the S
      Private Placement and/or the D Private Placement.

            (c) Fractional Shares. No fraction of a share of Alamar Common Stock
      will be  issued  by  virtue of the  Merger,  but in lieu of  thereof  each
      AccuMed  Shareholder  who would  otherwise  be entitled to a fraction of a
      share of Alamar Common Stock (after  aggregating all fractional  shares of
      Alamar  Common  Stock to be received by such  holder)  shall  receive from
      Alamar  one  additional  share of Alamar  Common  Stock in the event  such
      fraction  is one-half or more and no  additional  shares of Alamar  Common
      Stock in the event such fraction is less than one-half.

      1.7   Exchange of Certificates.

            (a) Alamar to Provide  Common  Stock.  Promptly  after the Effective
      Time, Alamar shall make available to each AccuMed Shareholder for exchange
      in accordance with this Article I, through such  reasonable  procedures as
      Alamar may adopt,  the shares of Alamar Common Stock issuable  pursuant to
      Section 1.6 in exchange for outstanding shares of AccuMed Capital Stock.

            (b) Exchange  Procedures.  Promptly after the Effective Time, Alamar
      shall  cause to be mailed to each  holder  of  record  of  certificate  or
      certificates (the "Certificates") which immediately prior to the Effective
      Time represented  outstanding shares of AccuMed Capital Stock whose shares
      were  converted  into the right to receive  shares of Alamar  Common Stock
      pursuant to Section 1.6, (i) a letter of transmittal  (which shall specify
      that  delivery  shall  be  effected,  and  risk of loss  and  title to the
      Certificates  shall pass, only upon delivery of the Certificates to Alamar
      and shall be in such form and have such  other  provisions  as Alamar  may
      reasonably  specify)  and  (ii)  instructions  for  use in  effecting  the
      surrender of the Certificates in exchange for three separate  certificates
      representing  shares of  Alamar  Common  Stock,  one such  certificate  to
      represent  Alamar Common Stock not subject to forfeiture  ("Vested  Alamar
      Common  Stock"),  one such  certificate  to represent  Alamar Common Stock
      subject to forfeiture  pursuant to Section 3.1 (as defined in such Section
      3.1,  the "First  Year  Performance  Stock") and one such  certificate  to
      represent  Alamar Common Stock  subject to forfeiture  pursuant to Section
      3.2 (as defined in such Section 3.2, "Second Year Performance Stock") (the
      Vested Alamar Common Stock,  First Year Performance  Stock and Second Year
      Performance Stock are sometimes collectively referred to as the "Exchanged
      Alamar Common Stock").


                                  -3-

<PAGE>



      Upon  surrender of a  Certificate  for  cancellation  to Alamar or to such
      other agent or agents as may be  appointed by Alamar,  together  with such
      letter of transmittal,  duly completed and validly  executed in accordance
      with the instructions  thereto,  the holder of such  Certificate  shall be
      entitled to receive in exchange therefor the certificates representing the
      number of whole shares of Exchanged  Alamar Common Stock which such holder
      has the right to receive  pursuant to Section 1.6, and the  Certificate so
      surrendered  shall  forthwith  be  canceled.  Until so  surrendered,  each
      outstanding  certificate that, prior to the Effective Time,  represented a
      share of AccuMed Capital Stock will be deemed from and after the Effective
      Time, for all corporate  purposes,  other than the payment of dividends or
      other  distributions,  to  evidence  the  ownership  of the number of full
      shares of Alamar  Common  Stock into which such shares of AccuMed  Capital
      Stock shall have been so converted in accordance with Section 1.6.

            (c) Distributions  With Respect to Unexchanged  Shares. No dividends
      or other  distributions  declared or made after the date of this Agreement
      with respect to Alamar Common Stock with a record date after the Effective
      Time will be paid to the  holder  of any  unsurrendered  Certificate  with
      respect to the shares of Alamar Common Stock represented thereby until the
      holder of record of such  Certificate  shall  surrender such  Certificate.
      Subject to applicable law,  following  surrender of any such  Certificate,
      there shall be paid to the record holder of the certificates  representing
      whole shares of Alamar Common Stock issued in exchange  therefor,  without
      interest, at the time of such surrender,  the amount of dividends or other
      distributions  with a record date after the  Effective  Time  payable with
      respect to such whole shares of Alamar Common Stock.

            (d) Transfers of Ownership.  If any certificate for shares of Alamar
      Common  Stock is to be  issued  in a name  other  than  that in which  the
      certificate  surrendered in exchange therefor is registered,  it will be a
      condition of the issuance thereof that the certificate so surrendered will
      be properly  endorsed  and  otherwise in proper form for transfer and that
      the person  requesting  such  exchange will have (i) paid to Alamar or any
      agent  designated by it any transfer or other taxes  required by reason of
      the  issuance of a  certificate  for shares of Alamar  Common Stock in any
      name  other  than  that  of  the  registered  holder  of  the  certificate
      surrendered or (ii) established to the satisfaction of Alamar or any agent
      designated by it that such tax has been paid or is not payable.

            (e) No Liability.  Notwithstanding  anything to the contrary in this
      Section 1.7, none of Alamar, AccuMed or the Surviving Corporation shall be
      liable to a holder of shares of Alamar  Common  Stock or  AccuMed  Capital
      Stock for any amount  properly paid to a public  official  pursuant to any
      applicable abandoned property, escheat or similar law.

      1.8 No Further  Ownership  Rights in AccuMed Capital Stock.  All shares of
Alamar  Common Stock issued upon the surrender for exchange of shares of AccuMed
Capital Stock in accordance  with the terms hereof  (including  any cash paid in
respect thereof) shall be deemed to have been issued in full satisfaction of all
rights pertaining to such shares of AccuMed Capital


                                     -4-

<PAGE>



Stock, and there shall be no further registration of transfers on the records of
the  Surviving  Corporation  of shares  of  AccuMed  Capital  Stock  which  were
outstanding  immediately  prior to the Effective  Time.  If, after the Effective
Time,  Certificates  are presented to the Surviving  Corporation for any reason,
they shall be canceled and exchanged as provided in this Article I.

      1.9 Lost, Stolen or Destroyed Certificates.  In the event any certificates
evidencing  shares of AccuMed  Capital  Stock  shall  have been lost,  stolen or
destroyed,  Alamar  shall issue in exchange  for such lost,  stolen or destroyed
certificates,  upon  the  making  of an  affidavit  of that  fact by the  holder
thereof,  such  shares  of  Exchanged  Alamar  Common  Stock as may be  required
pursuant to Section 1.6; provided,  however,  that Alamar may, in its discretion
and as a condition precedent to the issuance thereof,  require the owner of such
lost,  stolen or destroyed  certificates to deliver a bond in such sum as it may
reasonably direct as indemnity against any claim that may be made against Alamar
with respect to the certificates  alleged to have been lost, stolen or destroyed
or such other indemnity as may be reasonably requested by Alamar.

      1.10 Tax and Accounting Consequences. It is intended by the parties hereto
that the Merger shall constitute a reorganization  within the meaning of Section
368 of the Code.

      1.11 Taking of Necessary Action; Further Action. If, at any time after the
Effective  Time,  any further  action is necessary or desirable to carry out the
purposes  of this  Agreement  and to vest the  Surviving  Corporation  with full
right, title and possession to all assets, property, rights, privileges,  powers
and franchises of AccuMed and Alamar,  the officers and directors of AccuMed and
Alamar are fully  authorized  in the name of their  respective  corporations  or
otherwise to take, and will take, all such lawful and necessary  action, so long
as such action is consistent with this Agreement.

      1.12  Restrictions  on  Transfer.  No more  than 10% of the  shares of the
Exchanged  Alamar  Common  Stock  issued  to  each of the  AccuMed  Shareholders
pursuant  to this  Article I may be  offered  for  sale,  sold,  disposed  of or
otherwise  transferred or pledged or otherwise  encumbered until 18 months after
the  Effective  Time.  Transfers  by  gift,  will  or  intestacy  to an  AccuMed
Shareholder's  immediate  family or to a trust,  the  beneficiaries of which are
exclusively  such AccuMed  Shareholder  and/or  members of his or her  immediate
family,  will be  exempted,  so long as the  certificate  continues  to bear the
legend below. The Surviving Corporation will maintain stop transfer instructions
with its transfer agent at all appropriate  times to enforce this restriction on
transfer. The certificates  representing Exchanged Alamar Common Stock issued to
each AccuMed Shareholder  pursuant to this Agreement will bear substantially the
following legend:

      "The  securities  represented by this  certificate  are subject to certain
      restrictions  on  transfer  as set  forth  in the  Agreement  and  Plan of
      Reorganization by and between Alamar Biosciences, Inc. (the "Company") and
      AccuMed, Inc. dated April 21, 1995, a copy of which may be obtained at the
      principal  executive  office of the  Company.  Any  transfer  or pledge in
      conflict  with or in  derogation  of this  legend  is void and of no legal
      force, effect or validity whatsoever."


                                  -5-

<PAGE>



The  restriction  on transfer  imposed by this Section  1.12 shall  terminate 18
months  after  the  Effective  Time.  At any time 18  months  or more  after the
Effective  Time,  each  AccuMed  Shareholder  may  request,  and  the  Surviving
Corporation  will issue,  new  certificates of like tenor and amount without the
aforesaid restrictive legend.


                                  ARTICLE II
               OPTION TO PURCHASE ADDITIONAL ALAMAR COMMON STOCK

      2.1 Grant of Options.  In further  consideration of AccuMed's execution of
this  Agreement  and  consummation  of the Merger and the operation of AccuMed's
business by its management and employees  during the period from the date hereof
until the Closing Time for the ultimate benefit of Alamar,  Alamar shall, on the
Closing Date, grant to AccuMed's officers and employees, options (the "Options")
to purchase  from Alamar an  additional  750,000  shares of Alamar  Common Stock
plus, if the Option Price (as defined below) is greater than $1.25,  such number
of shares of Alamar  Common Stock as shall be determined  by  subtracting  $1.25
from the Option Price,  then  multiplying  by 750,000 and dividing by the Option
Price (collectively, the "Option Shares"). The Options shall be granted pursuant
to the Stock Option Plan of Alamar in effect as of the Closing Date (the "Option
Plan").  The  Option  Shares  shall  be  distributed  on the  Closing  Date,  as
determined  by the Board of  Directors  of AccuMed  prior to the  Closing  Date,
subject to  applicable  law and the terms of the Option Plan.  Alamar  covenants
that,  at all times from the date hereof until the earlier of the  expiration of
the Option Period (as hereinafter defined) or the exercise in full of all of the
Options,  Alamar  will have  reserved  for  issuance  under the Option Plan such
number of authorized but not issued and not outstanding  shares of Alamar Common
Stock as equals (a) the aggregate number of Option Shares issuable upon exercise
of  Options,  less (b) such  number of shares  of  Alamar  Common  Stock as have
previously  been  issued  upon  exercise  of  Options.  The Option Plan shall be
amended,  if necessary,  so that a sufficient  number of shares of Alamar Common
Stock are reserved for issuance upon exercise of Options, and any such amendment
shall  be  submitted  to  Alamar's  shareholders  for  approval  at  the  Alamar
Shareholders' Meeting.

      2.2 Option  Price.  The  purchase  price of each Option Share shall be the
Fair  Market  Value of Alamar  Common  Stock on the  Closing  Date (the  "Option
Price"),  payable  pursuant  to the terms of the Option  Plan.  Upon  payment to
Alamar of the Option Price,  Alamar shall assign,  transfer,  convey and deliver
the Option Shares purchased to the Option holder exercising the Option.

      2.3 Vesting and  Exercise  Period.  Each Option  shall have a term of five
years from the Closing Date (the "Option  Period") and shall vest in three equal
installments on the Closing Date and the first two anniversaries  thereof.  Each
Option must be  exercised  by written  notice given to Alamar at any time during
the Option  Period.  The  certificate or  certificates  for the shares of Alamar
Common  Stock as to which  the  Option  shall  have been so  exercised  shall be
delivered to the Option holder as soon as practicable after receipt by Alamar of
such notice and payment pursuant to Section 2.2 above. If not so exercised,  the
Option shall lapse.


                                     -6-

<PAGE>



      2.4 Option Terms.  Each Option  granted to an AccuMed  Shareholder  may be
exercised in whole or in part, and if exercised in part any remaining  shares of
Alamar  Common  Stock which were  subject to the Option may still be  purchased,
pursuant to the terms of such  Option by the Option  holder at any time prior to
the expiration of the Option Period.  Each Option holder may exercise his or her
Option  without  regard to the  exercise  or lack of  exercise  by other  Option
holders,  and  there  is no  requirement  that  any or all  of  the  Options  be
exercised.

      2.5  Adjustments.   Except  for  the  transactions  contemplated  by  this
Agreement,  if after the  Closing  Date there is any  change in the  outstanding
shares of Alamar  Common Stock by reason of a stock  dividend,  stock split,  or
combination  or  exchange  of  such  shares,  or any  recapitalization,  merger,
consolidation,  reorganization,  exchange or similar event, the number of shares
of Alamar Common Stock  available  for purchase  pursuant to the exercise of the
Options,  the number of such shares covered by each outstanding  Option, and the
Option  Price  shall be  proportionately  adjusted  by  Alamar to  reflect  such
changes;  provided,  however,  that any  fractional  shares  resulting from such
adjustment  shall be  eliminated  by rounding to the next lower whole  number of
shares.


                                 ARTICLE III
                      FORFEITURE OF ALAMAR COMMON STOCK

      3.1 First Year Performance  Targets.  If for the 12-month period beginning
on the first day of the first full fiscal  quarter of the Surviving  Corporation
commencing after the Effective Time (the "First Year  Performance  Period") both
(i) the  earnings  per  share of the  Surviving  Corporation  Common  Stock on a
fully-diluted  basis are less than  $.01 and (ii) the Fair  Market  Value of the
Surviving  Corporation Common Stock does not equal or exceed $2.00 per share for
a period of 45 consecutive trading days (the "First Year Performance  Targets"),
then the AccuMed  Shareholders  shall  forfeit and  surrender  to the  Surviving
Corporation  1,000,000  of the shares of the Alamar  Common Stock issued to them
pursuant  to  Article  I  (the  "First  Year  Performance  Stock"),  ratably  in
proportion to the number of Alamar Common Stock shares originally issued to each
such AccuMed Shareholder.

      3.2 Second Year Performance Targets. If for the 12-month period commencing
immediately after the end of the First Year Performance Period (the "Second Year
Performance  Period" and together with the First Year  Performance  Period,  the
"Performance  Periods")  both  (i)  the  earnings  per  share  of the  Surviving
Corporation  Common  Stock on a  fully-diluted  basis  ("fully  diluted" for the
purposes of this  Article III shall  included the First Year  Performance  Stock
whether or not  forfeited  pursuant to Section  3.1) are less than $.03 and (ii)
the Fair Market Value of the Surviving  Corporation  Common Stock does not equal
or exceed  $2.50 per share  for a period  of 45  consecutive  trading  days (the
"Second Year  Performance  Targets" and together with the First Year Performance
Targets, the "Performance Targets"), then the AccuMed Shareholders shall forfeit
and surrender to the Surviving Corporation an additional 1,000,000 of the shares
of the Alamar  Common  Stock  issued to them  pursuant to Article I (the "Second
Year Performance  Stock" and together with the First Year Performance Stock, the
"Performance Stock"), ratably in proportion to the number of Alamar Common Stock
shares originally issued to each such AccuMed Shareholder.


                                     -7-

<PAGE>



      3.3 Earn-Back  Provision.  If the Surviving  Corporation fails to meet its
First Year Performance  Targets,  but, for the Second Year  Performance  Period,
both (i) the earnings per share of the Surviving  Corporation  Common Stock on a
fully  diluted  basis is  greater  than or equal to the sum of  $0.03,  plus the
amount of any net loss per share incurred by the Surviving  Corporation  for the
First Year Performance  Period,  and (ii) the Fair Market Value of the Surviving
Corporation  Common Stock  equals or exceeds  $2.50 per share for a period of 45
consecutive  trading  days  (the  "Earn-Back  Targets"),  then  the  First  Year
Performance  Stock shall not be  forfeited  pursuant to Section  3.1, but rather
shall  become  fully  vested.  The First  Year  Performance  Stock  shall not be
surrendered  and  cancelled  pursuant to Section 3.4 until the end of the Second
Year  Performance  Period and the  determination  that this  Section 3.3 has not
served to vest such First Year Performance Stock.

      3.4 Surrender Procedure for Forfeited Performance Stock.  Determination as
to whether applicable Performance Targets are met with respect to the applicable
Performance  Period will be made by the Surviving  Corporation in its reasonable
discretion as soon as practicable  after the end of the  applicable  Performance
Period.  If  both  of the  applicable  Performance  Targets  are not met for the
applicable  Performance  Period,  and, in the case of the First Year Performance
Stock,  either of the Earn-Back  Targets set forth in Section 3.3 is not met for
the Second Year Performance  Period, each AccuMed Shareholder shall surrender to
the  Surviving  Corporation  within 30 days after  receipt of written  notice of
failure to meet such Performance Targets, his or her certificate or certificates
which  represents the forfeited  Performance  Stock,  provided that Alamar gives
notice  to  the  AccuMed  Shareholders  that  such  Performance  Stock  is to be
forfeited  within 90 days after the end of the Second Year  Performance  Period.
Each Performance Stock certificate which immediately after the end of the Second
Year  Performance  Period is  subject  to  forfeiture  shall be  deemed  for all
purposes to be cancelled  and void as of the end of the Second Year  Performance
Period. If any such Performance Stock  certificates are not delivered to Alamar,
Alamar shall make appropriate notations on its stock records,  which may include
stop transfer instructions.

      3.4  Adjustment.  The Performance  Targets and Earn-Back  Targets shall be
adjusted to reflect  fully the effect of any stock split,  reverse  stock split,
stock dividend (including any dividend or distribution of securities convertible
into Alamar Common Stock), reorganization, recapitalization or other like change
with respect to Alamar Common Stock  occurring  after the Effective Time if such
adjustment  would fairly  advance the  essential  intent and  principles  of the
Performance  Targets  and  Earn-Back  Targets as  determined  in good faith by a
majority of the disinterested directors of the Surviving Corporation.

      3.5  Restrictive  Legend  on  Performance  Stock;   Nontransferability  of
Performance  Stock. The certificates  representing  Performance  Stock issued to
each AccuMed Shareholder  pursuant to this Agreement will bear substantially the
following legend:

     "The securities  represented by this  certificate are subject to forfeiture
     and certain restrictions on transfer as set forth in the Agreement and Plan
     of Reorganization by and between Alamar  Biosciences,  Inc. (the "Company")
     and AccuMed,  Inc. dated April 21, 1995 (the "Agreement"),  a copy of which
     may be obtained  at the  principal  executive  office of the  Company.  Any
     transfer or pledge in conflict


                                  -8-

<PAGE>



     with or in  derogation  of the  Agreement  is void and of no  legal  force,
     effect, or validity whatsoever."

No Performance Stock shall be offered for sale, sold,  disposed of, or otherwise
transferred, or pledged or otherwise encumbered until such time as either of the
applicable  Performance  Targets  has been met or, in the case of the First Year
Performance Stock, both of the Earn-Back Targets have been met or until any such
Performance Stock is forfeited  pursuant to this Article III. Transfers by gift,
will or intestacy  to a  Performance  Stock  holder's  immediate  family or to a
trust, the  beneficiaries of which are exclusively such holder and/or members of
his or her immediate family, will be exempted,  so long as the Performance Stock
certificate  continues to bear the aforesaid legend. If either of the applicable
Performance  Targets is met during the applicable  Performance Period or, in the
case of the First Year Performance Stock, both of the Earn-Back Targets are met,
the Surviving  Corporation  will promptly  notify each AccuMed  Shareholder,  at
which time each AccuMed  Shareholder  may request the Surviving  Corporation  to
issue a new certificate with respect to the applicable Performance Stock of like
tenor and  amount  without  the  aforesaid  restrictive  legend.  The  Surviving
Corporation will cause appropriate  stock transfer  instructions to be placed in
the records of its transfer agent.


                                  ARTICLE IV
                  REPRESENTATIONS AND WARRANTIES OF ACCUMED

      AccuMed  represents and warrants to Alamar as of the date hereof and again
as of the Effective Time, subject to the exceptions  disclosed in writing in the
disclosure letter supplied to Alamar by AccuMed (the "AccuMed  Schedules") which
identifies the Section numbers hereof to which the disclosures pertain and which
is dated as of the date hereof and again as of the  Effective  Time and which is
attached to this Agreement and incorporated by reference, as set forth below.

      4.1 Organization of AccuMed.  AccuMed, and each of its subsidiaries as set
forth  on the  AccuMed  Schedules,  is a  corporation  duly  organized,  validly
existing  and in  good  standing  under  the  laws  of the  jurisdiction  of its
incorporation,  has the corporate  power to own,  lease and operate its property
and to carry on its  business  as now  being  conducted  and as  proposed  to be
conducted,  and is duly  qualified  to do  business  and in good  standing  as a
foreign corporation in each jurisdiction in which the failure to be so qualified
would have a Material Adverse Effect on AccuMed. A true and complete list of all
of AccuMed's  subsidiaries,  together with the  jurisdiction of incorporation of
each subsidiary is listed on the AccuMed Schedules. AccuMed does not directly or
indirectly  own any equity or similar  interest in, or any interest  convertible
into or  exchangeable  or  exercisable  for any  interest  in, any  corporation,
partnership,  joint venture or other  business  association  or entity except as
listed  on the  AccuMed  Schedules.  The  AccuMed  Schedules  contain a true and
correct copy of the Articles of Incorporation  and Bylaws of AccuMed and similar
governing instruments of each of its subsidiaries, each as amended to date.

      4.2 AccuMed  Capital  Structure.  The authorized  capital stock of AccuMed
consists as of the date hereof,  and will consist as of the  Effective  Time, of
5,000,000  shares of Common Stock,  no par value, of which as of the date hereof
there are 1,835,500 shares issued and


                                     -9-

<PAGE>



outstanding.   All  outstanding   shares  of  AccuMed  Capital  Stock  are  duly
authorized, validly issued, fully paid and non-assessable and are not subject to
preemptive rights created by statute, the Articles of Incorporation or Bylaws of
AccuMed or any  agreement or document to which AccuMed is a party or by which it
is bound. The AccuMed Schedules include a list of all issuances of capital stock
by AccuMed since its inception and contain a true, accurate and complete list of
the names and  respective  number of shares of AccuMed Common Stock held by each
AccuMed  Shareholder.  All shares of AccuMed  capital  stock have been issued in
compliance with all applicable  federal and state  securities laws, and no right
of rescission inures to any shareholder of AccuMed.

      4.3  Obligations  With  Respect to Capital  Stock.  Except as set forth in
Section  4.2,  there are no equity  securities  of any class of AccuMed,  or any
security  exchangeable into or exercisable for such equity  securities,  issued,
reserved  for  issuance or  outstanding.  Except for  securities  AccuMed  owns,
directly or indirectly  through one or more  subsidiaries  (which securities are
listed in the AccuMed Schedules), there are no equity securities of any class of
any subsidiary of AccuMed, or any security  exchangeable into or exercisable for
such equity securities, issued, reserved for issuance or outstanding.  Except as
set forth in Section 4.2,  there are no options,  warrants,  equity  securities,
calls,  rights,  commitments  or agreements of any character to which AccuMed or
any of its subsidiaries is a party or by which it is bound obligating AccuMed or
any of its  subsidiaries  to  issue,  deliver  or sell,  or cause to be  issued,
delivered or sold,  additional  shares of capital stock of AccuMed or any of its
subsidiaries or obligating AccuMed or any of its subsidiaries to grant,  extend,
accelerate  the  vesting  of or  enter  into any such  option,  warrant,  equity
security,  call,  right,  commitment or agreement.  To the knowledge of AccuMed,
there are no voting trusts,  proxies or other agreements or understandings  with
respect to the shares of capital stock of AccuMed.

      4.4   Authority.

            (a) AccuMed has all requisite corporate power and authority to enter
      into this Agreement and the  Transaction  Documents to which it is or will
      be a party, subject to obtaining requisite  shareholder  approval,  and to
      consummate the transactions  contemplated hereby or thereby. The execution
      and  delivery of this  Agreement  and the  Transaction  Documents to which
      AccuMed  is or will be a party and the  consummation  of the  transactions
      contemplated hereby and thereby have been duly authorized by all necessary
      corporate  action on the part of AccuMed,  subject only to the approval of
      the Merger by the vote of the holders of a majority of the AccuMed Capital
      Stock.  This Agreement has been duly executed and delivered by AccuMed and
      constitutes  the valid and binding  obligation of AccuMed,  enforceable in
      accordance  with its  terms,  except as  enforceability  may be limited by
      bankruptcy and other similar laws and general principles of equity.

            (b) The execution and delivery by AccuMed of this  Agreement and the
      Transaction  Documents  to which  AccuMed  is or will be a party do not or
      will not, and the consummation of the transactions  contemplated hereby or
      thereby will not, conflict with, or result in any violation of, or default
      under (with or without notice or lapse of time, or both),  or give rise to
      a right of termination,


                                  -10-

<PAGE>



      cancellation  or  acceleration  of any  obligation  or loss of any benefit
      under (i) any provision of the Articles of Incorporation,  as amended,  or
      Bylaws, as amended, of AccuMed or similar governing  instruments of any of
      its subsidiaries or (ii) any material mortgage, indenture, lease, contract
      or other agreement or instrument, permit, concession,  franchise, license,
      judgment,  order,  decree,  statute,  law,  ordinance,  rule or regulation
      applicable  to AccuMed  or its  properties  or assets  other than any such
      conflicts,   violations,   defaults,   terminations,    cancellations   or
      accelerations which would not have a Material Adverse Effect on AccuMed or
      have a material adverse effect on the ability of AccuMed to consummate the
      transactions contemplated hereby or thereby.

            (c)  No   consent,   approval,   order  or   authorization   of,  or
      registration,  declaration  or filing  with,  any  Governmental  Entity is
      required by or with respect to AccuMed in  connection  with the  execution
      and  delivery  of  this  Agreement  or the  Transaction  Documents  or the
      consummation of the transactions  contemplated  hereby or thereby,  except
      for  (i) the  filing  of the  Agreement  of  Merger  with  the  California
      Secretary  of State,  (ii) the filing of the  Agreement of Merger with the
      Illinois  Secretary  of State,  (iii) such  consents,  approvals,  orders,
      authorizations, registrations, declarations and filings as may be required
      under  applicable  federal and state  securities  laws and the laws of any
      foreign  country and (iv) such other  consents,  authorizations,  filings,
      approvals and registrations which, if not obtained or made, would not have
      a Material Adverse Effect on AccuMed.

      4.5 Taxes and Tax Returns.  Except as disclosed in the AccuMed  Schedules,
AccuMed and its subsidiaries  have timely filed all Tax Returns required to have
been filed, and such returns are true and correct.  AccuMed and its subsidiaries
have paid or have adequately  reserved for the payment of all Taxes that have or
may become due  pursuant to said Tax  Returns,  or  pursuant  to any  assessment
received with respect thereto. There are no present or threatened disputes as to
Taxes payable by AccuMed.  There have been no federal,  state,  foreign or local
audits of income,  sales, ad valorem or other Taxes payable by AccuMed or any of
its  subsidiaries.  There are no  unexpired  waivers  by  AccuMed  or any of its
subsidiaries  of any  statute of  limitations  with  respect  to any Taxes,  and
neither  AccuMed  nor any of its  subsidiaries  is a  party  to any  actions  or
proceedings  by any  Governmental  Entity for the  collection  or  assessment of
Taxes.

      4.6 Restrictions on Business  Activities.  There is no material agreement,
judgment,  injunction,  order  or  decree  binding  upon  AccuMed  or any of its
subsidiaries  which has or could  reasonably  be  expected to have the effect of
prohibiting or materially  impairing any material current  business  practice of
AccuMed or any of its  subsidiaries,  any  acquisition  of material  property by
AccuMed or any of its  subsidiaries or the conduct of business by AccuMed or any
of its  subsidiaries  as  currently  conducted or as proposed to be conducted by
AccuMed or any of its subsidiaries.

      4.7  Absence  of  Liens  and   Encumbrances.   AccuMed  and  each  of  its
subsidiaries  has good and valid title to, or, in the case of leased  properties
and  assets,  valid  leasehold  interests  in,  all of their  material  tangible
properties and assets,  real,  personal and mixed, used in their business,  free
and clear of any liens or encumbrances except as reflected in the AccuMed


                                     -11-

<PAGE>



Schedules  and  except  for liens for  taxes  not yet due and  payable  and such
imperfections  of title and  encumbrances,  if any,  which are not  material  in
character, amount or extent, and which do not materially detract from the value,
or materially interfere with the present use, of the property subject thereto or
affected  thereby.  A complete  list of all leased  and owned real  property  of
AccuMed and each of its subsidiaries is set forth in the AccuMed Schedules.

      4.8  Proprietary  Rights.  The AccuMed  Schedules  contain a complete  and
accurate list of all patented and registered Proprietary Rights owned by AccuMed
and  each  of  its  subsidiaries   and  all  pending  patent   applications  and
applications for the registration of other Proprietary  Rights owned or filed by
AccuMed and each of its  subsidiaries.  The  AccuMed  Schedules  also  contain a
complete and accurate  list of all trade or corporate  names used by AccuMed and
each of its  subsidiaries  and a complete and accurate  list of all licenses and
other rights granted by AccuMed and each of its  subsidiaries to any third party
with respect to Proprietary  Rights and licenses and other rights granted by any
third party to AccuMed and each of its subsidiaries.  Except as set forth on the
AccuMed Schedules,  (a) AccuMed and each of its subsidiaries own and possess all
right, title and interest in and to, or have a valid and enforceable  license to
use, all of the Proprietary  Rights necessary for the operation of AccuMed's and
each of its  subsidiaries'  respective  businesses as presently  conducted or as
currently  proposed by AccuMed to be conducted;  (b) no claim by any third party
contesting  the  validity,   enforceability,   use  or  ownership  of  any  such
Proprietary Rights has been made, is currently  outstanding or, to the knowledge
of AccuMed or any of its  subsidiaries,  is threatened,  and to the knowledge of
AccuMed or any of its  subsidiaries,  there is no reasonable  basis for any such
claim;  (c) neither AccuMed nor any of its subsidiaries nor any registered agent
of AccuMed or any of its  subsidiaries  has  received  any notices of, nor is it
aware  of any  reasonable  basis  for an  allegation  of,  any  infringement  or
misappropriation  by, or conflict  with,  any third  party with  respect to such
Proprietary Rights, nor has AccuMed or any of its subsidiaries or any registered
agent of AccuMed or any of its subsidiaries  received any claims of infringement
or  misappropriation  of or other  conflict with any  Proprietary  Rights of any
third party;  and (d) neither AccuMed nor any of its subsidiaries has infringed,
misappropriated  or  otherwise  violated  any  Proprietary  Rights  of any third
parties,  nor is AccuMed or any of its subsidiaries  aware of any  infringement,
misappropriation  or  conflict  which  will  occur as a result of the  continued
operation  of  AccuMed's  or any  of its  subsidiaries'  business  as  presently
conducted  or as  currently  proposed  by  AccuMed  to be  conducted.  Except as
disclosed in the AccuMed  Schedules,  to the  knowledge of AccuMed or any of its
subsidiaries,  AccuMed and each of its  subsidiaries  are not obligated or under
any  liability  whatsoever  to make any  payments by way of  royalties,  fees or
otherwise  to any owner of,  licensor  of, or other  claimant  to,  any  patent,
trademark,  trade name, copyright, trade secret or other intangible assets, with
respect to the use thereof or in connection  with the conduct of its business or
otherwise.  To the  knowledge  of  AccuMed  or any  of its  subsidiaries,  it is
currently  not  necessary  nor will it be  necessary  for  AccuMed or any of its
subsidiaries to utilize nor will AccuMed or any of its subsidiaries  utilize any
inventions  of any persons or entities (or people it currently  intends to hire)
made or owned prior to their employment by or affiliation with AccuMed or any of
its subsidiaries,  nor is it or will it be necessary to utilize any other assets
or rights of any such  persons or entities  (or people it  currently  intends to
hire) made or owned prior to their  employment  with or engagement by AccuMed or
any of its  subsidiaries,  in violation of any  limitations or  restrictions  to
which any such  person  or  entity is a party or to which any of such  assets or
rights may be subject.  To the knowledge of AccuMed or any of its  subsidiaries,
neither AccuMed nor any of its subsidiaries' employees, consultants, officers,


                                     -12-

<PAGE>



directors  or  shareholders  has taken,  removed or made use of any  proprietary
documentation,  manuals, products, materials or any other tangible item from his
or her previous  employer relating to the business as conducted of such previous
employer which has resulted in AccuMed or any of its subsidiaries'  access to or
use of such  proprietary  items.  Except as disclosed  in the AccuMed  Schedules
hereto,  all  actions  required  to  be  taken  to  transfer  interest  in  such
Proprietary  Rights to AccuMed or any of its  subsidiaries  have been taken, all
notices required to be made in connection with such transfer have been made, and
all consents  required to be secured in connection  with such transfer have been
secured.

      4.9 Contracts.  The AccuMed  Schedules contain a true and complete list of
every material contract, understanding,  agreement, relationship and commitment,
written or oral,  to which AccuMed or any of its  subsidiaries  is a party or by
which  its  or  any  of  its  subsidiaries'   properties  is  bound  or  subject
(collectively,  the "AccuMed  Contracts").  Except as expressly set forth in the
AccuMed Schedules,  (a) all such AccuMed Contracts are in full force and effect,
enforceable  in  accordance  with  their  terms;  (b)  AccuMed  and  each of its
subsidiaries has performed in all material respects all obligations  required to
be  performed  by  each  of  them  thereunder;  (c)  AccuMed  and  each  of  its
subsidiaries is not, nor, to the knowledge of AccuMed, is any other party to any
such  AccuMed  Contract in default in any  material  respect or alleged to be in
default in any material respect under the terms thereof; and (d) there exists no
condition which,  after notice or lapse of time or both, would constitute such a
default by AccuMed or any of its subsidiaries or which would otherwise allow the
other contracting party to terminate any such AccuMed Contract.  Neither AccuMed
nor any of its  subsidiaries has received written notice or, to the knowledge of
AccuMed or any of its subsidiaries, any other notice, that any party to any such
AccuMed  Contract  intends to cancel or  terminate,  or to  exercise  any option
under, any such AccuMed Contract.  For purposes of this Section 4.9, a contract,
agreement,  relationship  or commitment  is deemed  material if it gives rise to
rights  or  liabilities  on the  part  of  AccuMed  or  any of its  subsidiaries
exceeding  $10,000 in the  aggregate,  or is one of a series of related  AccuMed
Contracts,  commitments,  agreements or relationships  with the same contracting
party or group of affiliated  parties that in the aggregate  give rise to rights
or liabilities exceeding such amount.

      4.10  Governmental  Authorization.  AccuMed  and each of its  subsidiaries
holds all Permits  which are material to the  operation of AccuMed's and each of
its  subsidiaries'  business  as  currently  conducted.  AccuMed and each of its
subsidiaries  is in  material  compliance  with the terms of such  Permits.  The
business  of AccuMed  and each of its  subsidiaries  is not being  conducted  in
violation  of any Laws,  except for  violations  or  possible  violations  which
individually  or in the  aggregate  do not,  and  insofar as  reasonably  can be
foreseen,  in the future will not have a Material  Adverse Effect on AccuMed and
its  subsidiaries,  taken  as a  whole.  As of the  date of this  Agreement,  no
investigation  or review by any  Governmental  Entity with respect to AccuMed or
any of its subsidiaries is pending or, to the knowledge of AccuMed or any of its
subsidiaries, threatened, nor has any Governmental Entity indicated an intention
to conduct the same.

      4.11  Intentionally Deleted.

      4.12  Intentionally Deleted.


                                     -13-

<PAGE>



      4.13 Litigation. Except as set forth in the AccuMed Schedules:

            (a) there are no claims, actions,  suits, inquiries,  proceedings or
      investigations  pending  or,  to  the  best  of  AccuMed's  or  any of its
      subsidiaries  knowledge,  threatened  by or against  AccuMed or any of its
      subsidiaries  relating  to any  product  alleged  to have  been  designed,
      manufactured, sold or licensed by AccuMed or any subsidiary and alleged to
      have been  defective,  improperly  designed or  manufactured or improperly
      labeled;

            (b) there are no claims, actions,  suits, inquiries,  proceedings or
      investigations  pending  or,  to  the  knowledge  AccuMed  or  any  of its
      subsidiaries, threatened by or against AccuMed or any of its subsidiaries,
      at law or in equity or before or by any Governmental Entity.  AccuMed does
      not know of any basis for any such  claim,  action,  suit,  proceeding  or
      investigation; and

            (c) there are no  contracts  between  AccuMed  and any  Governmental
      Entity  purporting to impose any  affirmative  action or equal  employment
      opportunities  upon  AccuMed  or  any  of  its  subsidiaries  relating  to
      AccuMed's or any of its  subsidiaries'  employees  and with regard to said
      employees so far as AccuMed or any of its  subsidiaries is aware.  Neither
      AccuMed nor any of its subsidiaries is a government  contractor within the
      meaning of Executive Order No. 11246,  the Vietnam  Veterans  Readjustment
      Assistance Act of 1974, or the Rehabilitation Act of 1973.

      4.14  Health, Safety and Environment.

            (a) Compliance with Environmental and Safety  Requirements.  AccuMed
      and  each  of  its  subsidiaries  is in  compliance  with  all  applicable
      Environmental  and  Safety  Requirements,  and  AccuMed  and  each  of its
      subsidiaries possess all required permits, licenses and certificates,  and
      have filed all notices or applications, required thereby.

            (b) No  Hazardous  Wastes.  Except  as  set  forth  in  the  AccuMed
      Schedules,  AccuMed and each of its subsidiaries  have not ever generated,
      transported,  treated,  stored or  disposed  of any  Hazardous  Wastes (as
      hereinafter  defined)  at any  site,  location  or  facility  and no  such
      Hazardous  Wastes are present on, in or under any real  property  owned or
      used by AccuMed or any of its  subsidiaries,  and such  property  does not
      contain (including  containment by means of any underground  storage tank)
      any Hazardous Waste.

            (c) No  Actions  or  Proceedings.  Neither  AccuMed  nor  any of its
      subsidiaries  has been subject to, or received  any written  notice or, to
      the knowledge of AccuMed or any of its subsidiaries,  any other notice of,
      any private,  administrative or judicial action, or any written notice or,
      to the knowledge of AccuMed or any of its  subsidiaries,  any other notice
      of any intended private, administrative or judicial action relating to the
      presence or alleged  presence of  Hazardous  Wastes in,  under or upon any
      real property owned


                                  -14-

<PAGE>



      or used by AccuMed or any of its  subsidiaries,  and Accumed does not know
      and has no reason to know of any  reasonable  basis for any such notice or
      action; and there are no pending or, to the knowledge of AccuMed or any of
      its  subsidiaries,  threatened  actions  or  proceedings  (or  notices  of
      potential  actions or  proceedings)  from any  governmental  agency or any
      other entity regarding any matter relating to health, safety or protection
      of the environment.

            (d) Other  Conditions.  To the  knowledge  of  AccuMed or any of its
      subsidiaries,  no facts,  events or conditions with respect to the past or
      present  operations  or facilities of AccuMed,  it  subsidiaries  or their
      businesses  exist which could  reasonably be expected to interfere with or
      prevent continued compliance with, or could give rise to any common law or
      statutory  liability  or  otherwise  form the basis of any claim,  action,
      suit,  proceeding,  hearing or investigation against or involving AccuMed,
      its  subsidiaries  or their  business under any  Environmental  and Safety
      Requirement  based on any such  fact,  event  or  circumstance,  including
      liability for cleanup costs, personal injury or property damage.

      4.15  Brokers'  and Finders'  Fees.  Except for fees payable to Lake Shore
Capital  Partners,  Inc.  pursuant to the engagement letter dated April 21, 1994
(which along with all amendments thereto is attached to the AccuMed  Schedules),
and the fees payable to Commonwealth Associates pursuant to an engagement letter
dated February 14, 1995, AccuMed has not incurred,  nor will it incur,  directly
or  indirectly,  any  liability  for  brokerage  or  finders'  fees  or  agents'
commissions  or any similar  charges in  connection  with this  Agreement or any
transaction contemplated hereby.

      4.16 Labor Matters.  There are no pending  material claims against AccuMed
or any of its subsidiaries under any workers  compensation plan or policy or for
long term disability. AccuMed and each of its subsidiaries, have complied in all
material  respects with all  applicable  provisions of COBRA and, if applicable,
similar foreign laws and has no material  obligations with respect to any former
employees or  qualifying  beneficiaries  thereunder.  Except as set forth in the
AccuMed  Schedules,  neither AccuMed nor any of its  subsidiaries  has any labor
unions or collective bargaining  agreements with employees.  Except as set forth
in the  AccuMed  Schedules,  there is no,  and  neither  AccuMed  nor any of its
subsidiaries has experienced any, strike,  picketing,  boycott, work stoppage or
slowdown or other labor  dispute or, to the  knowledge of AccuMed or each of its
subsidiaries,  any union  organizational  activity or any  complaint  of, or any
allegation,  charge or reasonable  basis for any allegation or charge of, unfair
labor  practice,  employment  discrimination  or other  matters  relating to the
employment  of labor.  To the  knowledge of AccuMed or any of its  subsidiaries,
after due  inquiry,  no such  complaint,  allegation  or charge of unfair  labor
practice or employment discrimination has been threatened against AccuMed or any
of its subsidiaries which is likely to have a Material Adverse Effect on AccuMed
and its  subsidiaries,  taken as a whole.  To the knowledge of AccuMed or any of
its  subsidiaries,  no key employee  and no group of employees  has any plans to
terminate  employment with AccuMed.  AccuMed and each of its  subsidiaries  have
complied in all  material  respects  with all  applicable  laws  relating to the
employment of labor,  including  provisions  thereof  relating to wages,  hours,
equal opportunity,  collective bargaining and the payment of social security and
other taxes. Except as set forth in the AccuMed Schedules, there are no


                                     -15-

<PAGE>



administrative  charges or court  complaints  pending  or, to the  knowledge  of
AccuMed or any of its  subsidiaries,  threatened  against  AccuMed or any of its
subsidiaries  before the EEOC or any state or federal court or agency concerning
alleged  employment   discrimination  or  any  other  matters  relating  to  the
employment of labor.

      4.17  Employee Benefit Plans.

            (a) The AccuMed  Schedules set forth all employee  benefit plans (as
      defined in  Section  3(3) of ERISA) and all  bonus,  stock  option,  stock
      purchase,  incentive,  deferred  compensation,   supplemental  retirement,
      severance  and  other  similar   employee   benefit  plans,   programs  or
      arrangements,   and  any  current  or  former   employment   or  executive
      compensation  or  severance  agreements,  written  or  otherwise,  for the
      benefit of, or relating to, any current or former  employees of AccuMed or
      any trade or business (whether or not  incorporated)  which is a member or
      which is under common control with AccuMed (an "ERISA  Affiliate")  within
      the  meaning  of Section  414 of the Code,  or any  subsidiary  of AccuMed
      (collectively, the "AccuMed Employee Plans").

            (b) The AccuMed  Schedules  set forth a complete and correct list of
      each plan, policy or arrangement (written or oral) providing for insurance
      coverage (including any self-insured arrangements), workers' compensation,
      disability benefits,  supplemental employment benefits, vacation benefits,
      fringe  benefits or other forms of  compensation  or benefits which (i) is
      not  an  AccuMed  Employee  Plan,  (ii)  is  maintained,   established  or
      contributed  to by AccuMed or any  subsidiary or any related  person,  and
      (iii)  covers any  employee  or former  employee of AccuMed or any related
      person, including any employee or former employee of a related person that
      does business outside of the United States. Such plans and arrangements as
      are  described  above are  hereinafter  referred  to  collectively  as the
      "AccuMed Benefit Arrangements".

            (c) (i) None of the AccuMed  Employee Plans or Benefit  Arrangements
      promises or provides  retiree medical or other retiree welfare benefits to
      any person except as required by applicable law, including COBRA; (ii) all
      AccuMed  Employee Plans and AccuMed Benefit  Arrangements  are, and during
      the six-year  period ending on the date hereof have been, in compliance in
      all  material  respects  with the  requirements  prescribed  by,  and have
      complied with the reporting and  disclosure  requirements  of, any and all
      applicable   statutes   (including  ERISA  and  the  Code),   orders,   or
      governmental  rules  and  regulations  currently  in effect  with  respect
      thereto  (including  all  applicable   requirements  for  notification  to
      participants or beneficiaries or the Department of Labor, Internal Revenue
      Service  (the  "IRS") or  Secretary  of the  Treasury  or similar  foreign
      regulatory  authority),  and  AccuMed  and each of its  subsidiaries  have
      performed all material  obligations  required to be performed by it under,
      is not in default  under or  violation  of, and have no  knowledge  of any
      default or  violation  by any other party to, any of the AccuMed  Employee
      Plans or AccuMed Benefit  Arrangements;  (iii) each AccuMed  Employee Plan
      intended  to  qualify  under  Section  401(a)  of the Code and each  trust
      intended to qualify under Section 501(a) of the Code either has


                                  -16-

<PAGE>



      received  a  favorable  determination  letter  with  respect  to each such
      AccuMed Employee Plan from the IRS or still has a remaining period of time
      under applicable  Treasury  Regulations or IRS  pronouncements in which to
      apply for such a determination letter and to make any amendments necessary
      to obtain a favorable determination;  and (iv) no AccuMed Employee Plan or
      AccuMed  Benefit  Arrangement  is or  within  the prior six years has been
      subject to, and neither AccuMed nor any of its  subsidiaries  has incurred
      and nor expects to incur any liability under, Title IV of ERISA or Section
      412 of the Code and (v)  nothing in any AccuMed  Employee  Plan or AccuMed
      Benefit Arrangement precludes or interferes with Alamar's ability to cause
      AccuMed to  terminate  (or  consolidate,  at Alamar's  option) any AccuMed
      Employee Plan or AccuMed Benefit  Arrangement after the Closing;  provided
      that (i) the AccuMed  Employee Plans and AccuMed Benefit  Arrangements may
      be terminated  prospectively  only, subject to rights accrued by AccuMed's
      employees at the time of such  termination and (ii) not more than 60 days'
      notice may be required to terminate  certain  AccuMed  Employee  Plans and
      AccuMed Benefit Arrangements.

            (d) Each AccuMed  Employee Plan and AccuMed Benefit  Arrangement has
      been  maintained  in  substantial  compliance  with  its  terms,  and  all
      contributions,  premiums or other  payments due from AccuMed or any of its
      subsidiaries  to (or  under)  any such  AccuMed  Employee  Plan or AccuMed
      Benefit  Arrangement  have  been  fully  paid for the most  recently-ended
      fiscal  year.  All  accruals  thereon   (including,   where   appropriate,
      proportional  accruals for partial  periods)  have been made in accordance
      with GAAP consistently  applied on a reasonable  basis.  There has been no
      amendment, written interpretation or announcement (whether or not written)
      by  AccuMed  or any of its  subsidiaries  with  respect  to,  or change in
      employee  participation  or coverage under,  any AccuMed  Employee Plan or
      AccuMed Benefit  Arrangement that would increase materially the expense of
      maintaining such plans or arrangements,  individually or in the aggregate,
      above the level of expense  incurred  with  respect  thereto  for the most
      recently-ended fiscal year. All non-U.S.  Plans and Arrangements are fully
      funded under applicable law.

            (e) AccuMed has made  available  to Alamar  complete,  accurate  and
      current  copies  of  all  AccuMed   Employee  Plans  and  AccuMed  Benefit
      Arrangements  and all amendments,  documents,  correspondence  and filings
      relating thereto, including, but not limited to, any statements,  filings,
      reports or returns filed with any governmental  agency with respect to the
      AccuMed Employee Plans and AccuMed Benefit Arrangements at any time within
      the three-year period ending on the date hereof.

      4.18 Change of Control Payments.  No amounts shall become payable (whether
currently  or in the  future)  to  current  or  former  officers,  directors  or
employees of AccuMed or any of its  subsidiaries as a result of or in connection
with the Merger.


                                     -17-

<PAGE>



      4.19 Registration Statement; Proxy  Statement/Prospectus.  The information
supplied in writing by AccuMed for inclusion in the  Registration  Statement (as
hereinafter  defined) shall not at the time the Registration  Statement is filed
with the SEC and at the time it  becomes  effective  under the  Securities  Act,
contain any untrue  statement  of a material  fact or omit to state any material
fact required to be stated  therein or necessary in order to make the statements
therein not  misleading.  AccuMed has reviewed the  disclosures in the S Private
Placement document relating to AccuMed and its subsidiaries and represents that,
to its  knowledge,  such  disclosures  do not contain any untrue  statement of a
material fact or omit to state any material  fact required to be stated  therein
or  necessary  in order to make  the  statements  therein  not  misleading.  The
information   supplied  in  writing  by  AccuMed  for  inclusion  in  the  proxy
statement/prospectus to be sent to the shareholders of Alamar in connection with
the  meeting of  Alamar's  shareholders  to  consider  the Merger  (the  "Alamar
Shareholders'   Meeting")  (such  proxy   statement/prospectus   as  amended  or
supplemented is referred to herein as the "Proxy  Statement")  shall not, on the
date the Proxy  Statement is first mailed to the Alamar's  shareholders,  at the
time of the Alamar Shareholders'  Meeting and at the Effective Time, contain any
untrue  statement of a material fact or omit to state any material fact required
to be stated  therein or necessary in order to make the statements  therein,  in
light of the  circumstances  under which they are made, not false or misleading;
or omit to state any material  fact  necessary  to correct any  statement in any
earlier communication with respect to the solicitation of proxies for the Alamar
Shareholders' Meeting which has become false or misleading. If at any time prior
to the Effective  Time any event  relating to AccuMed or any of its  affiliates,
officers or directors  should be discovered by AccuMed which should be set forth
in an amendment  to the  Registration  Statement  or a  supplement  to the Proxy
Statement, AccuMed shall promptly inform Alamar.  Notwithstanding the foregoing,
AccuMed  makes no  representation  or warranty  with respect to any  information
supplied by or  concerning  Alamar which is  contained  in any of the  foregoing
documents.

      4.20 No Illegal Payments.  Neither AccuMed nor any of its subsidiaries has
not, directly or indirectly,  paid or delivered,  accepted,  or agreed to pay or
deliver any remuneration,  fee,  commission or sum of money or item of property,
however characterized,  to any Person,  government official or other party which
is in any manner  related to the business of AccuMed or any of its  subsidiaries
and which AccuMed or any of its  subsidiaries  knows or has reason to believe to
have been  illegal  under any  federal,  state or local  law,  which  payment or
delivery may impose liability on Alamar.

      4.21 Board Approval. The Board of Directors of AccuMed has, on or prior to
the date hereof, unanimously approved this Agreement and the Merger.

      4.22 Insurance Policies. The AccuMed Schedules contain a true and complete
list of all policies of insurance  currently  owned or maintained by AccuMed and
each of its  subsidiaries  with respect to their  business.  Said list  includes
policy numbers, identity of insurers and a description of the type and amount of
coverage under each such policy. All such policies are in full force and effect,
and AccuMed has not  received  notice of  cancellation  or intent to cancel with
respect thereto or is aware of any basis for such action.


                                     -18-

<PAGE>



      4.23  Financial  Statements.  AccuMed has prepared and delivered to Alamar
the  following  financial  statements:  (a) an unaudited  Income  Statement  for
AccuMed  for the period  from  February 7, 1994 to  December  31,  1994,  (b) an
unaudited  Balance Sheet for AccuMed dated  December 31, 1994,  (c) an unaudited
consolidated Income Statement for AccuMed and its subsidiary for the period from
January 1, 1995 to February 28, 1995, and (d) an unaudited  consolidated Balance
Sheet for AccuMed  and its  subsidiary  dated  February  28, 1995 (the  "AccuMed
Balance Sheet"). These financial statements were not prepared in accordance with
GAAP, nor were they reviewed or compiled by independent public accountants, but,
to the knowledge of AccuMed after due inquiry, these financial statements fairly
presented the assets,  liabilities and financial position of AccuMed and (to the
extent  applicable)  its subsidiary as of the  respective  dates thereof and the
results of their operations for the periods indicated.

      4.24 No  Undisclosed  Liabilities.  To the  knowledge of AccuMed after due
inquiry,  except as set forth in the AccuMed Schedules,  AccuMed has no material
liabilities or  obligations of any nature  (whether known or unknown and whether
absolute,   accrued,   contingent  or  otherwise)   other  than  liabilities  or
obligations  reflected  or  reserved  against in the AccuMed  Balance  Sheet and
current liabilities incurred in the ordinary course of business, consistent with
past practices, since the date of the AccuMed Balance Sheet.

      4.25  Absence of  Certain  Changes.  Except as  disclosed  on the  AccuMed
Schedules,  since February 28, 1995, neither AccuMed nor any of its subsidiaries
has:

            (a) Granted any general  increase in the compensation of officers or
      employees  (including  any such increase  pursuant to any bonus,  pension,
      profit  sharing  or other  plan or  commitment),  or any  increase  in the
      compensation  payable  or to become  payable to any  officer or  employee,
      except regularly scheduled increases consistent with past experience;

            (b) Made any single  capital  expenditure or commitment in excess of
      $5,000 for additions to property,  plant,  equipment or intangible capital
      assets or made aggregate capital expenditures and commitments in excess of
      $5,000 for additions to property,  plant,  equipment or intangible capital
      assets;

            (c)  Declared,  paid or set aside for payment any  dividend or other
      distribution  in respect of its capital  stock or  redeemed,  purchased or
      otherwise acquired, directly or indirectly, any shares of capital stock or
      other equity securities of AccuMed or any subsidiary;

            (d) Paid, loaned or advanced any amount to, or sold,  transferred or
      leased any  properties  or assets  (real,  personal or mixed,  tangible or
      intangible) to, or entered into any agreement or arrangement  with, any of
      its  officers or  directors  or any  affiliate  or associate of any of its
      officers or directors,  except for  regularly  scheduled  compensation  to
      officers;

            (e)   Changed its method of accounting or accounting practices;


                                  -19-

<PAGE>



            (f) Written off any notes or accounts  receivable  as  uncollectible
      other then in the  ordinary  course of business and  consistent  with past
      practices;

            (g)  Discharged  or satisfied  any lien or  encumbrance  or paid any
      obligation  or  liability  (whether  absolute,   accrued,   contingent  or
      otherwise and whether due or to become due) other than current liabilities
      shown on the AccuMed Financial Statements and current liabilities incurred
      in the ordinary course of business and consistent with past practice;

            (h) Sold, assigned,  transferred,  mortgaged,  pledged or encumbered
      any of its assets  (real,  personal  or mixed,  tangible  or  intangible),
      cancelled any debts or claims or waived any rights of  substantial  value,
      except,  in each case, in the ordinary  course of business and  consistent
      with past practice;

            (i) Sold,  assigned or transferred  any patents,  trademarks,  trade
      names,  copyrights  or other similar  assets,  including  applications  or
      licenses therefor;

            (j) Entered into any  transaction  other than in the ordinary course
      of business or otherwise contemplated by this Agreement; or

            (k)  Entered  into  any  agreement  or  commitment  to do any of the
      foregoing.

      4.26 Manufacturing,  Distribution and License Rights.  Except as disclosed
in the AccuMed Schedules,  neither AccuMed nor any subsidiary has granted rights
or licenses to manufacture,  assemble,  distribute, license or sell its products
to any person or entity, is bound by any agreement that affects AccuMed's or its
subsidiaries' exclusive right to manufacture,  assemble,  distribute, license or
sell AccuMed's or its subsidiaries' products, or has licensed or sold any of its
technology or Proprietary Rights to any person or entity.

      4.27  Customers  and  Distributors.  Except as  disclosed  in the  AccuMed
Schedules, neither AccuMed nor any of its subsidiaries has actual knowledge that
any  customer or  distributor  has  ceased,  or intends to cease,  utilizing  or
purchasing the goods or services,  or distributing the products,  of AccuMed and
its subsidiaries,  or has  substantially  reduced,  or intends  substantially to
reduce,  the use or purchase of such goods or services,  or the  distribution of
such products.

      4.28  Suppliers.  AccuMed  has no actual  knowledge  that any  supplier of
AccuMed or any of its subsidiaries will not sell goods and services to Alamar at
any time after the  Effective  Time on terms and  conditions  and in  quantities
similar to those of prior sales to AccuMed.

      4.29 Full Disclosure.  AccuMed is not aware of any facts directly relating
to its or its subsidiaries' business or property (excluding, without limitation,
any fact  relating to  economic,  business,  political  or  industry  conditions
generally)  which it  believes  affect  materially  adversely  such  business or
property  or which it  believes  are likely in the  future to affect  materially
adversely  such  business  or  property  which have not been  disclosed  in this
Agreement  or the AccuMed  Schedules or been  otherwise  disclosed in writing to
Alamar.


                                     -20-

<PAGE>



      4.30 No  Misrepresentation.  None of the representations and warranties of
AccuMed set forth in this  Agreement or in any of the  certificates,  schedules,
lists, documents,  exhibits, or other instruments delivered, or to be delivered,
to Alamar as contemplated by any provision hereof,  contains, or will contain at
the Effective  Time, any untrue  statement of a material fact or omits,  or will
omit at the Effective  Time,  any material fact necessary to make the statements
contained herein or therein not misleading.


                                   ARTICLE V
                   REPRESENTATIONS AND WARRANTIES OF ALAMAR

      Alamar  represents and warrants to AccuMed as of the date hereof and again
as of the Effective Time, subject to the exceptions  disclosed in writing in the
disclosure  letter supplied to AccuMed by Alamar (the "Alamar  Schedules") which
identifies the Section numbers hereof to which the disclosures pertain and which
is dated as of the date hereof and again as of the  Effective  Time and which is
attached to this Agreement and incorporated by reference, as set forth below.

      5.1  Organization  of  Alamar.  Alamar is a  corporation  duly  organized,
validly  existing and in good standing under the laws of the jurisdiction of its
incorporation,  has the corporate  power to own,  lease and operate its property
and to carry on its  business  as now  being  conducted  and as  proposed  to be
conducted,  and is duly  qualified  to do  business  and in good  standing  as a
foreign corporation in each jurisdiction in which the failure to be so qualified
would have a Material  Adverse  Effect on Alamar.  Alamar  does not  directly or
indirectly  own any equity or similar  interest in, or any interest  convertible
into or  exchangeable  or  exercisable  for any  interest  in, any  corporation,
partnership,  joint venture or other business  association or entity. The Alamar
Schedules  contain true and correct copy of the  Articles of  Incorporation  and
Bylaws or other charter documents of Alamar, each as amended to date. Alamar has
no subsidiaries.

      5.2   Capital Structure.

            (a) The authorized  capital stock of Alamar  consists as of the date
      hereof of  30,000,000  shares  of Common  Stock,  no par  value,  of which
      5,140,939  shares were issued and  outstanding  as of April 21, 1995,  and
      5,000,000  shares of  Preferred  Stock,  no par  value,  none of which are
      issued or outstanding.  All such shares have been duly authorized, and all
      such issued and  outstanding  shares have been validly  issued,  are fully
      paid and  nonassessable  and are free of any liens or  encumbrances  other
      than any liens or  encumbrances  created  by or imposed  upon the  holders
      thereof. As of April 21, 1995, Alamar has also reserved (i) 724,985 shares
      of Common Stock for issuance to employees, officers or directors of Alamar
      under the 1990 Alamar  Option Plan and the 1992 Alamar  Option  Plan,  and
      (ii)  4,070,964  shares of Common Stock for issuance  upon exercise of the
      Alamar  Warrants.  As of April 21, 1995,  of the 724,985  shares of Alamar
      Common  Stock  reserved for issuance  upon  exercise of options  therefor,
      581,809 shares  remained  subject to  outstanding  options with a weighted
      average  exercise price of  approximately  $1.30,  and 173,176 shares were
      reserved for future grant.  As of April 21, 1995, of the 4,070,964  shares
      of

                                  -21-

<PAGE>



      Alamar  Common  Stock  reserved  for  issuance  upon  exercise  of  Alamar
      Warrants, 4,070,964 shares remained subject to outstanding Alamar Warrants
      with a weighted  average  exercise price of  approximately  $4.38,  and no
      shares were reserved for future  grant.  All shares of Alamar Common Stock
      subject  to  issuance  as  aforesaid,  upon  issuance  on  the  terms  and
      conditions  specified  in the  instruments  pursuant  to  which  they  are
      issuable,  shall  be duly  authorized,  validly  issued,  fully  paid  and
      nonassessable.  Except as set forth in the Alamar Schedules,  there are no
      other equity securities,  options, warrants, calls, rights, commitments or
      agreements  of any  character to which Alamar is a party or by which it is
      bound obligating Alamar to issue, deliver,  sell, repurchase or redeem, or
      cause to be issued,  delivered,  sold, repurchased or redeemed, any shares
      of the capital  stock of Alamar or obligating  Alamar to grant,  extend or
      enter  into  any such  equity  security,  option,  warrant,  call,  right,
      commitment  or  agreement.  All shares of Alamar  capital  stock have been
      issued in  compliance  with all  applicable  federal and state  securities
      laws, and no right of rescission inures to any shareholder of Alamar.

            (b) The shares of Alamar  Common Stock to be issued  pursuant to the
      Merger will, upon issuance, be duly authorized, validly issued, fully paid
      and non-assessable.

      5.3   Authority.

            (a) Alamar has all requisite  corporate power and authority to enter
      into this Agreement and the  Transaction  Documents to which it is or will
      be a party, subject to obtaining requisite  shareholder  approval,  and to
      consummate the transactions  contemplated hereby or thereby. The execution
      and delivery of this Agreement and the  Transaction  Documents to which it
      is  or  will  be  a  party  and  the   consummation  of  the  transactions
      contemplated  hereby or thereby have been duly authorized by all necessary
      corporate action on the part of Alamar subject only to the approval of the
      Merger by Alamar's  shareholders as  contemplated by Section 8.1(a).  This
      Agreement has been duly  executed and delivered by Alamar and  constitutes
      the valid,  binding and enforceable  obligation of Alamar,  enforceable in
      accordance  with its  terms,  except as  enforceability  may be limited by
      bankruptcy and other similar laws and general principles of equity.

            (b) The execution  and delivery by Alamar of this  Agreement and the
      Transaction Documents to which Alamar is or will be a party do not or will
      not,  and the  consummation  of the  transactions  contemplated  hereby or
      thereby will not, conflict with, or result in any violation of, or default
      under (with or without notice or lapse of time, or both),  or give rise to
      a right of termination,  cancellation or acceleration of any obligation or
      loss of a benefit under (i) any provision of the Articles of Incorporation
      or  Bylaws  of Alamar or (ii) any  material  mortgage,  indenture,  lease,
      contract or other agreement or instrument, permit, concession,  franchise,
      license,  judgment,  order,  decree,  statute,  law,  ordinance,  rule  or
      regulation applicable to Alamar or its properties or assets other than any
      such conflicts, violations, defaults, terminations, cancellations or

                                  -22-

<PAGE>



      accelerations  which would not have a Material Adverse Effect on Alamar or
      have a material  adverse effect on the ability of Alamar to consummate the
      transactions contemplated hereby or thereby.

            (c)  No   consent,   approval,   order  or   authorization   of,  or
      registration,  declaration or filing with,  any  Governmental  Entity,  is
      required by or with respect to Alamar in connection with the execution and
      delivery of this  Agreement  or the  Transaction  Documents to which it is
      party  by  Alamar  or the  consummation  by  Alamar  of  the  transactions
      contemplated hereby or thereby, except for (i) the filing of the Agreement
      of Merger with the California  Secretary of State,  (ii) the filing of the
      Agreement of Merger with the Illinois Secretary of State, (iii) the filing
      of the  Registration  Statement  with  the  SEC  in  accordance  with  the
      Securities  Act,  (iv) the filing of the Proxy  Statement  with the SEC in
      accordance  with the  Exchange  Act, (v) the filing of a Form 8-K and Form
      10-C  with the SEC  within  15 days and 10 days,  respectively,  after the
      Closing Date, (vi) any filings as may be required under  applicable  state
      securities laws and the laws of any foreign country,  and (vii) such other
      consents,  authorizations,  filings,  approvals and registrations which if
      not obtained or made would not have a Material Adverse Effect on Alamar.

      5.4   SEC Filings; Alamar Financial Statements.

            (a)  Alamar  has filed on a timely  basis  all  forms,  reports  and
      documents  required to be filed with the SEC since  October 14, 1992,  and
      Alamar has made available to AccuMed,  in the form filed with the SEC, (i)
      its Annual Reports on Form 10-KSB for the fiscal years ended September 30,
      1992,  1993 and 1994,  respectively,  (ii) its  Quarterly  Reports on Form
      10-QSB for the period ended December 31, 1994,  (ii) all proxy  statements
      relating to Alamar's meetings of shareholders  (whether annual or special)
      held since  September  30, 1992,  (iv) all other  reports or  registration
      statements  filed by Alamar with the SEC since  September 30, 1992 and (v)
      all  amendments  and  supplements  to all such  reports  and  registration
      statements filed by Alamar with the SEC. All such required forms,  reports
      and documents  (including  those  enumerated in clauses (i) through (v) of
      the  preceding  sentence)  are  referred  to  herein  as the  "Alamar  SEC
      Reports".  As of their  respective  dates, the Alamar SEC Reports (i) were
      prepared in accordance with the  requirements of the Securities Act or the
      Exchange Act, as the case may be, and the rules and regulations of the SEC
      thereunder  applicable  to such Alamar SEC Reports and (ii) did not at the
      time they were filed (or if amended or superseded by a filing prior to the
      date of this  Agreement,  then on the  date of such  filing)  contain  any
      untrue  statement  of a  material  fact or omit to state a  material  fact
      required to be stated therein or necessary in order to make the statements
      therein, in the light of the circumstances under which they were made, not
      misleading.

            (b) Each of the consolidated  financial  statements  (including,  in
      each case, any related notes thereto) contained in the Alamar SEC Reports,
      including  any Alamar SEC Reports  filed  after the date hereof  until the
      Closing, (x)

                                  -23-

<PAGE>



      complies as to form in all material  respects with the published rules and
      regulations  of  the  SEC  with  respect  thereto,  (y)  was  prepared  in
      accordance with GAAP applied on a consistent  basis throughout the periods
      involved  (except as may be indicated in the notes thereto) and (z) fairly
      presented the assets,  liabilities and financial  position of Alamar as of
      the  respective  dates thereof and the results of its  operations and cash
      flows  for the  periods  indicated,  except  that  the  unaudited  interim
      financial  statements were or are subject to normal and recurring year-end
      adjustments  which were not or are not  expected to be material in amount.
      The audited  balance sheet of Alamar  contained in the Alamar SEC Reports,
      as of  September  30,  1994,  is  hereinafter  referred  to as the "Alamar
      Balance Sheet".

            (c) Alamar has  heretofore  furnished or made available to AccuMed a
      complete and correct copy of any amendments or  modifications,  which have
      not yet been filed  with the SEC but which are  required  to be filed,  to
      agreements, documents or other instruments which previously had been filed
      by Alamar with the SEC pursuant to the Securities Act or the Exchange Act.

      5.5   Intentionally Deleted.

      5.6 Taxes, Tax Returns and Audits. Alamar has timely filed all Tax Returns
required to have been filed,  and such returns are true and correct.  Alamar has
paid or has  adequately  reserved  in the Alamar  Financial  Statements  for the
payment of all Taxes that have or may become due  pursuant to said Tax  Returns,
or pursuant to any assessment received with respect thereto. Except as disclosed
in the Alamar Schedules, there are no present or threatened disputes as to Taxes
payable by Alamar. There have been no federal, state, foreign or local audits of
income,  sales,  ad valorem or other Taxes payable by Alamar except as disclosed
in the Alamar Schedules and any deficiencies proposed as a result of such audits
have  been paid or  settled.  There are no  unexpired  waivers  by Alamar of any
statute of limitations  with respect to any Taxes,  and Alamar is not a party to
any actions or  proceedings  by any  Governmental  Entity for the  collection or
assessment of Taxes.

      5.7 Restrictions on Business  Activities.  There is no material agreement,
judgment,  injunction,  order  or  decree  binding  upon  Alamar  which  has  or
reasonably  would be expected to have the effect of  prohibiting  or  materially
impairing any material current business  practice of Alamar,  any acquisition of
material  property by Alamar or the  conduct of business by Alamar as  currently
conducted or as proposed to be conducted by Alamar.

      5.8 Absence of Liens and Encumbrances. Alamar has good and valid title to,
or, in the case of leased properties and assets,  valid leasehold  interests in,
all of its material tangible  properties and assets,  real,  personal and mixed,
used in its  business,  free and  clear of any liens or  encumbrances  except as
reflected in the Alamar Financial  Statements and except for liens for taxes not
yet due and payable and such  imperfections of title and  encumbrances,  if any,
which  are not  material  in  character,  amount  or  extent,  and  which do not
materially detract from the value, or materially interfere with the present use,
of the property  subject  thereto or affected  thereby.  A complete  list of all
Alamar leased and owned real property is set forth in the Alamar Schedules.

                                     -24-

<PAGE>




      5.9  Proprietary  Rights.  The Alamar  Schedules  contain a  complete  and
accurate list of all patented and registered  Proprietary Rights owned by Alamar
and all pending patent  applications  and  applications  for the registration of
other  Proprietary  Rights owned or filed by Alamar.  The Alamar  Schedules also
contain a complete  and accurate  list of all trade or  corporate  names used by
Alamar and a complete and accurate list of all licenses and other rights granted
by Alamar to any third party with respect to Proprietary Rights and licenses and
other  rights  granted by any third party to Alamar.  Except as set forth on the
Alamar Schedules, (a) Alamar owns and possesses all right, title and interest in
and to, or has a valid license to use, all of the Proprietary  Rights  necessary
for the  operation of Alamar's  business as presently  conducted or as currently
proposed by Alamar to be conducted;  (b) no claim by any third party  contesting
the validity,  enforceability,  use or ownership of any such Proprietary  Rights
has been made,  is currently  outstanding  or, to the  knowledge  of Alamar,  is
threatened, and to the knowledge of Alamar, there is no reasonable basis for any
such claim;  (c) none of Alamar nor any registered  agent of Alamar has received
any notices of, nor are they aware of any reasonable basis for an allegation of,
any infringement or misappropriation  by, or conflict with, any third party with
respect to such  Proprietary  Rights,  nor has Alamar or any registered agent of
Alamar  received  any claims of  infringement  or  misappropriation  of or other
conflict with any Proprietary  Rights of any third party; and (d) Alamar has not
infringed,  misappropriated  or otherwise violated any Proprietary Rights of any
third parties,  nor is aware of any infringement,  misappropriation  or conflict
which will occur as a result of the continued  operation of Alamar's business as
presently  conducted or as currently proposed by Alamar to be conducted.  Except
as disclosed in the Alamar Schedules,  to the knowledge of Alamar, Alamar is not
obligated  or under any  liability  whatsoever  to make any  payments  by way of
royalties, fees or otherwise to any owner of, licensor of, or other claimant to,
any patent, trademark,  trade name, copyright,  trade secret or other intangible
assets, with respect to the use thereof or in connection with the conduct of its
business or otherwise. To the knowledge of Alamar, it is currently not necessary
nor will it be  necessary  for Alamar to utilize nor will  Alamar,  nor is it or
will it be  necessary to utilize any  inventions  of any persons or entities (or
people it currently  intends to hire) made or owned prior to their employment by
or  affiliation  with  Alamar nor is it or will it be  necessary  to utilize any
other  assets  or  rights  of any of such  persons  or  entities  (or  people it
currently  intends  to hire)  made or owned  prior to their  employment  with or
engagement by Alamar or in violation of any limitations or restrictions to which
any such  person or  entity is a party or to which any of such  assets or rights
may be subject. Except as disclosed in the Alamar Schedules, to the knowledge of
Alamar,  none  of  Alamar's  employees,  consultants,   officers,  directors  or
shareholders  has taken,  removed or made use of any proprietary  documentation,
manuals, products, materials or any other tangible item from his or her previous
employer  relating to the business as conducted of such previous  employer which
has resulted in Alamar's access to or use of such proprietary  items.  Except as
disclosed in the Alamar  Schedules  hereto,  all actions required to be taken to
transfer  interest in such  Proprietary  Rights to Alamar  have been taken,  all
notices required to be made in connection with such transfer have been made, and
all consents  required to be secured in connection  with such transfer have been
secured.

      5.10 Contracts.  The Alamar Schedules  contain a true and complete list of
every material contract, understanding,  agreement, relationship and commitment,
written or oral, to which Alamar is a party or by which its  properties is bound
or subject (collectively, the "Alamar Contracts"). Except as expressly set forth
in the Alamar  Schedules,  (a) all such Alamar  Contracts  are in full force and
effect, enforceable in accordance with their terms; (b)

                                     -25-

<PAGE>



Alamar has  performed in all material  respects all  obligations  required to be
performed by it thereunder;  (c) Alamar is not, nor, to the knowledge of Alamar,
is any other  party to any such  Alamar  Contract  in  default  in any  material
respect or alleged to be in  default  in any  material  respect  under the terms
thereof;  and (d) there exists no condition which, after notice or lapse of time
or both,  would  constitute  such a default by Alamar or which  would  otherwise
allow the other contracting party to terminate any such Alamar Contract.  Alamar
has not  received  written  notice nor, to the  knowledge  of Alamar,  any other
notice,  that  any  party to any such  Alamar  Contract  intends  to  cancel  or
terminate,  or to  exercise  any option  under,  any such Alamar  Contract.  For
purposes of this Section 5.10, a contract, agreement, relationship or commitment
is deemed material if it (i) is, or has been, required to be filed as an exhibit
to the Alamar SEC  Reports  or (ii) gives rise to rights or  liabilities  on the
part of Alamar  exceeding  $10,000  in the  aggregate,  or is one of a series of
related Alamar Contracts, commitments, agreements or relationships with the same
contracting party or group of affiliated parties that in the aggregate give rise
to rights or liabilities exceeding such amount.

      5.11  Governmental  Authorization.  Alamar  holds  all  Permits  which are
material to the operation of Alamar's business as currently conducted. Alamar is
in material  compliance  with the terms of such Permits.  Except as set forth on
the Alamar Schedules, the business of Alamar is not being conducted in violation
of any Laws, except for violations or possible  violations which individually or
in the  aggregate do not,  and insofar as  reasonably  can be  foreseen,  in the
future will not,  have a Material  Adverse  Effect on Alamar.  As of the date of
this  Agreement,  no  investigation  or review by any  Governmental  Entity with
respect to Alamar is pending or, to the knowledge of Alamar, threatened, nor has
any Governmental Entity indicated an intention to conduct the same.

      5.12  Intentionally Deleted.

      5.13  Intentionally Deleted.

      5.14 Litigation. Except as set forth in the Alamar Schedules:

            (a) there are no claims, actions,  suits, inquiries,  proceedings or
      investigations  pending or, to the  knowledge of Alamar,  threatened by or
      against  Alamar  relating  to any product  alleged to have been  designed,
      manufactured,  sold or  licensed  by  Alamar  and  alleged  to  have  been
      defective, improperly designed or manufactured or improperly labeled;

            (b) there are no claims, actions,  suits, inquiries,  proceedings or
      investigations  pending or, to the  knowledge of Alamar,  threatened by or
      against  Alamar  at law or in  equity  or  before  or by any  Governmental
      Entity.  Alamar  does not know of any  basis for any such  claim,  action,
      suit, proceeding or investigation; and

            (c) there  are no  contracts  between  Alamar  and any  Governmental
      Entity  purporting to impose any  affirmative  action or equal  employment
      opportunities  upon Alamar relating to Alamar's  employees and with regard
      to said  employees  so far as Alamar is aware.  Alamar is not a government
      contractor

                                  -26-

<PAGE>



      within the meaning of Executive Order No. 11246, the Vietnam Veterans
      Readjustment Assistance Act of 1974, or the Rehabilitation Act of 1973.

      5.15  Health, Safety and Environment.

            (a) Compliance with Environmental and Safety Requirements. Alamar is
      in compliance with all applicable  Environmental and Safety  Requirements,
      and Alamar possesses all required permits, licenses and certificates,  and
      has filed all notices or applications, required thereby.

            (b)  No  Hazardous  Wastes.  Except  as  set  forth  in  the  Alamar
      Schedules, Alamar has not ever generated, transported, treated, stored, or
      disposed of any Hazardous Wastes at any site,  location or facility and no
      such Hazardous  Wastes are present on, in or under any real property owned
      or  used  by  Alamar,  and  such  property  does  not  contain  (including
      containment by means of any underground storage tank) any Hazardous Waste.

            (c) No Actions or  Proceedings.  Alamar has not been  subject to, or
      received  any written  notice or, to the  knowledge  of Alamar,  any other
      notice of, any private,  administrative or judicial action, or any written
      notice or, to the  knowledge  of Alamar,  any other notice of any intended
      private,  administrative,  or judicial  action relating to the presence or
      alleged  presence of Hazardous  Wastes in, under or upon any real property
      owned or used by  Alamar,  and  Alamar  does not know and has no reason to
      know of any reasonable basis for any such notice or action;  and there are
      no  pending  or,  to  the  knowledge  of  Alamar,  threatened  actions  or
      proceedings  (or notices of  potential  actions or  proceedings)  from any
      governmental  agency or any other entity  regarding any matter relating to
      health, safety or protection of the environment.

            (d) Other Condition. To the knowledge of Alamar, no facts, events or
      conditions with respect to the past or present operations or facilities of
      Alamar or its  business  exist  which  could  reasonably  be  expected  to
      interfere with or prevent continued compliance with, or could give rise to
      any common law or statutory  liability or otherwise  form the basis of any
      claim,  action,  suit,  proceeding,  hearing or  investigation  against or
      involving  Alamar or its  business  under  any  Environmental  and  Safety
      Requirement  based on any such  fact,  event  or  circumstance,  including
      liability for cleanup costs, personal injury or property damage.

      5.16 Broker's and Finders' Fees.  Except for fees payable to  Commonwealth
pursuant to the engagement  letter dated  February 14, 1995 and the fees,  costs
and expenses  payable to Commonwealth  in connection with this Agreement,  the S
Private Placement and the D Private Placement,  all of which have been disclosed
in writing to AccuMed,  and fees payable to Bridgemere  Capital  pursuant to the
engagement  letter dated March 29, 1995,  copies of which have been  provided to
Accumed,  Alamar has not incurred,  and will not incur,  directly or indirectly,
any  liability  for  brokerage or finders'  fees or agents'  commissions  or any
similar charges in connection with this Agreement, the Merger or any transaction
contemplated hereby.

                                     -27-

<PAGE>




      5.17 Labor Matters.  There are no pending  material  claims against Alamar
under any  workers  compensation  plan or  policy  or for long term  disability.
Alamar and each of its United States subsidiaries,  has complied in all material
respects with all  applicable  provisions of COBRA and, if  applicable,  similar
foreign  laws  and  has no  material  obligations  with  respect  to any  former
employees or  qualifying  beneficiaries  thereunder.  Except as set forth in the
Alamar Schedules, Alamar has no labor unions or collective bargaining agreements
with its employees.  Except as set forth in the Alamar Schedules,  there is not,
and  within  the last  three  years  Alamar  has not  experienced,  any  strike,
picketing,  boycott, work stoppage or slowdown or other labor dispute or, to the
knowledge of Alamar, any union  organizational  activity or any complaint of, or
any  allegation,  charge or  reasonable  basis for any  allegation or charge of,
unfair labor practice,  employment  discrimination  or other matters relating to
the employment of labor. To the knowledge of Alamar,  after due inquiry, no such
complaint,   allegation  or  charge  of  unfair  labor  practice  or  employment
discrimination  has been threatened  against Alamar which is likely to adversely
affect  Alamar.  To the  knowledge  of Alamar,  no key  employee and no group of
employees has any plans to terminate employment with Alamar. Alamar has complied
in all material  respects with all applicable laws relating to the employment of
labor, including provisions thereof relating to wages, hours, equal opportunity,
collective bargaining and the payment of social security and other taxes. Except
as set forth in the Alamar  Schedules,  there are no  administrative  charges or
court  complaints  pending or, to the  knowledge of Alamar,  threatened  against
Alamar  before  the EEOC or any  state or  federal  court or  agency  concerning
alleged  employment   discrimination  or  any  other  matters  relating  to  the
employment of labor.

      5.18  Employee Benefit Plans.

            (a) The Alamar  Schedules  set forth all employee  benefit plans (as
      defined in  Section  3(3) of ERISA) and all  bonus,  stock  option,  stock
      purchase,  incentive,  deferred  compensation,   supplemental  retirement,
      severance  and  other  similar   employee   benefit  plans,   programs  or
      arrangements,   and  any  current  or  former   employment   or  executive
      compensation  or  severance  agreements,  written  or  otherwise,  for the
      benefit of, or relating  to, any current or former  employees of Alamar or
      any trade or business (whether or not  incorporated)  which is a member or
      which is under common  control with Alamar (an "Alamar  ERISA  Affiliate")
      within the meaning of Section 414 of the Code, or any subsidiary of Alamar
      (collectively, the "Alamar Employee Plans").

            (b) The Alamar  Schedules  set forth a complete  and correct list of
      each plan, policy or arrangement (written or oral) providing for insurance
      coverage (including any self-insured arrangements), workers' compensation,
      disability benefits,  supplemental employment benefits, vacation benefits,
      fringe  benefits or other forms of  compensation  or benefits which (i) is
      not  an  Alamar  Employee  Plan,   (ii)  is  maintained,   established  or
      contributed  to by Alamar or any  related  person,  and (iii)  covers  any
      employee or former employee of Alamar or any related person, including any
      employee or former employee of a related person that does business outside
      of the United States.  Such plans and  arrangements as are described above
      are   hereinafter   referred  to   collectively  as  the  "Alamar  Benefit
      Arrangements".


                                  -28-

<PAGE>



            (c)  (i)  None  of the  Alamar  Employee  Plans  or  Alamar  Benefit
      Arrangements promises or provides retiree medical or other retiree welfare
      benefits to any person  except as required by  applicable  law,  including
      COBRA; (ii) all Alamar Employee Plans and Alamar Benefit Arrangements are,
      and during the  six-year  period  ending on the date hereof have been,  in
      compliance in all material  respects with the requirements  prescribed by,
      and have complied with the reporting and disclosure  requirements  of, any
      and all applicable  statutes  (including ERISA and the Code),  orders,  or
      governmental  rules  and  regulations  currently  in effect  with  respect
      thereto  (including  all  applicable   requirements  for  notification  to
      participants or beneficiaries or the Department of Labor, IRS or Secretary
      of the Treasury or similar foreign regulatory  authority),  and Alamar has
      performed all material  obligations  required to be performed by it under,
      is not in  default  under or  violation  of, and has no  knowledge  of any
      default or  violation  by any other  party to, any of the Alamar  Employee
      Plans or Alamar  Benefit  Arrangements;  (iii) each Alamar  Employee  Plan
      intended  to  qualify  under  Section  401(a)  of the Code and each  trust
      intended to qualify under Section 501(a) of the Code either has received a
      favorable  determination  letter with respect to each such Alamar Employee
      Plan from the IRS or still has a remaining period of time under applicable
      Treasury  Regulations or IRS  pronouncements  in which to apply for such a
      determination  letter  and to make any  amendments  necessary  to obtain a
      favorable  determination;  and  (iv) no  Alamar  Employee  Plan or  Alamar
      Benefit  Arrangement is or within the prior six years has been subject to,
      and Alamar  has not  incurred  and does not expect to incur any  liability
      under, Title IV of ERISA or Section 412 of the Code and (v) nothing in any
      Alamar Employee Plan or Alamar Benefit Arrangement precludes or interferes
      with AccuMed's  ability to cause Alamar to terminate (or  consolidate,  at
      AccuMed's  option) any Alamar Employee Plan or Alamar Benefit  Arrangement
      after the Closing;  provided that (i) the Alamar Employee Plans and Alamar
      Benefit  Arrangements  may be terminated  prospectively  only,  subject to
      rights accrued by Alamar's  employees at the time of such  termination and
      (ii) not more than 60 days'  notice may be required to  terminate  certain
      Alamar Employee Plans and Alamar Benefit Arrangements.

            (d) Each Alamar  Employee Plan and Alamar  Benefit  Arrangement  has
      been  maintained  in  substantial  compliance  with  its  terms,  and  all
      contributions,  premiums or other  payments  due from Alamar or any of its
      subsidiaries to (or under) any such Alamar Employee Plan or Alamar Benefit
      Arrangement have been fully paid for the most recently-ended  fiscal year.
      All accruals thereon (including, where appropriate,  proportional accruals
      for partial  periods) have been made in accordance with GAAP  consistently
      applied  on a  reasonable  basis.  There  has been no  amendment,  written
      interpretation  or  announcement  (whether or not  written) by Alamar with
      respect to, or change in employee  participation  or coverage  under,  any
      Alamar  Employee Plan or Alamar  Benefit  Arrangement  that would increase
      materially  the  expense  of  maintaining   such  plans  or  arrangements,
      individually or in the aggregate, above the level of expense incurred with
      respect  thereto for the most  recently-ended  fiscal  year.  All non-U.S.
      Plans and Arrangements are fully funded under applicable law.

                                  -29-

<PAGE>




            (e) Alamar has made  available  to AccuMed  complete,  accurate  and
      current   copies  of  all  Alamar   Employee   Plans  and  Alamar  Benefit
      Arrangements  and all amendments,  documents,  correspondence  and filings
      relating thereto,  including any statements,  filings,  reports or returns
      filed with any  governmental  agency with  respect to the Alamar  Employee
      Plans and Alamar  Benefit  Arrangements  at any time within the three-year
      period ending on the date hereof.

      5.19  Change  of  Control  Payments.  Except  as set  forth on the  Alamar
Schedules,  no amounts shall become payable (whether currently or in the future)
to current or former  officers,  directors or employees of Alamar as a result of
or in connection with the Merger.

      5.20 Registration Statement; Proxy Statement/Prospectus.  The Registration
Statement on Form S-4 (or such other or successor form as shall be appropriate),
(including any amendments or supplements thereto, the "Registration Statement"),
pursuant to which the shares of Alamar  Common  Stock to be issued in the Merger
will be  registered  with  the SEC  shall  not,  at the  time  the  Registration
Statement is filed with the SEC and at the time it becomes  effective  under the
Securities Act, contain any untrue statement of a material fact or omit to state
any material fact necessary in order to make the statements included therein not
misleading.  The Proxy  Statement  shall not, on the date the Proxy Statement is
first mailed to shareholders,  at the time of the Alamar  Shareholders'  Meeting
and at the Effective  Time,  contain any untrue  statement of a material fact or
omit to state any material  fact  required to be stated  therein or necessary in
order to make the statements  therein, in light of the circumstances under which
they are made,  not false or  misleading,  or omit to state any material  affect
necessary to correct any statement in any earlier  communication with respect to
the  solicitation  of proxies  for the Alamar  Shareholders'  Meeting  which has
become false or misleading. Alamar has reviewed the disclosures in the S Private
Placement  document  and  represents  that such  disclosures  do not contain any
untrue  statement of a material fact or omit to state any material fact required
to be stated  therein or necessary in order to make the  statements  therein not
misleading.  The  Registration  Statement will comply as to form in all material
respects with the applicable  provisions of the Securities Act and the rules and
regulations  thereunder.  The  Proxy  Statement  will  comply  as to form in all
material  respects  with the  applicable  provisions of the Exchange Act and the
rules and regulations  thereunder.  The S Private Placement document will comply
as to form in all material  respects with the  provisions of the  Securities Act
and the rules and regulations thereunder.  If at any time prior to the Effective
Time any event relating to Alamar or any of its respective affiliates,  officers
or  directors  should be  discovered  by Alamar  which should be set forth in an
amendment to the  Registration  Statement or S Private  Placement  document or a
supplement  to  the  Proxy  Statement,  Alamar  will  promptly  inform  AccuMed.
Notwithstanding  the foregoing,  Alamar makes no representation or warranty with
respect to any  information  supplied  by AccuMed  for  inclusion  in any of the
foregoing documents.

      5.21 No Illegal Payments. Alamar has not, directly or indirectly,  paid or
delivered,  accepted,  or  agreed  to  pay or  deliver  any  remuneration,  fee,
commission or sum of money or item of property,  however  characterized,  to any
Person, government official or other party which is in any manner related to the
business of Alamar and which  Alamar knows or has reason to believe to have been
illegal  under any federal,  state or local law,  which  payment or delivery may
impose liability on AccuMed.


                                     -30-

<PAGE>



      5.22 Board Approval.  The Board of Directors of Alamar has, as of the date
hereof, approved this Agreement and the Merger.

      5.23 Insurance Policies.  The Alamar Schedules contain a true and complete
list of all policies of insurance  currently  owned or maintained by Alamar with
respect to its business. Said list includes policy numbers, identity of insurers
and a description of the type and amount of coverage under each such policy. All
such policies are in full force and effect,  and Alamar has not received  notice
of  cancellation  or intent to cancel  with  respect  thereto or is aware of any
basis for such action.

      5.24 No  Undisclosed  Liabilities.  To the  knowledge  of Alamar after due
inquiry,  except as set forth in the Alamar  Schedules,  Alamar has no  material
liabilities or  obligations of any nature  (whether known or unknown and whether
absolute,   accrued,   contingent,  or  otherwise)  other  then  liabilities  or
obligations  reflected  or  reserved  against  in the Alamar  Balance  Sheet and
current liabilities incurred in the ordinary course of business, consistent with
past practices, since the date of the Alamar Balance Sheet.

      5.25  Intentionally Deleted.

      5.26  Absence  of  Certain  Changes.  Except as  disclosed  on the  Alamar
Schedules, since December 31, 1994, Alamar has not:

            (a) Granted any general  increase in the compensation of officers or
      employees  (including  any such increase  pursuant to any bonus,  pension,
      profit  sharing  or other  plan or  commitment),  or any  increase  in the
      compensation  payable  or to become  payable to any  officer or  employee,
      except regularly scheduled increases consistent with past experience;

            (b) Made any single  capital  expenditure or commitment in excess of
      $5,000 for additions to property,  plant,  equipment or intangible capital
      assets or made aggregate capital expenditures and commitments in excess of
      $5,000 for additions to property,  plant,  equipment or intangible capital
      assets;

            (c)  Declared,  paid or set aside for payment any  dividend or other
      distribution  in respect of its capital  stock or  redeemed,  purchased or
      otherwise acquired, directly or indirectly, any shares of capital stock or
      other equity securities of Alamar;

            (d) Paid, loaned or advanced any amount to, or sold,  transferred or
      leased any  properties  or assets  (real,  personal or mixed,  tangible or
      intangible) to, or entered into any agreement or arrangement  with, any of
      its  officers or  directors  or any  affiliate  or associate of any of its
      officers or directors,  except for  regularly  scheduled  compensation  to
      officers;

            (e)   Changed its method of accounting or accounting practices;


                                     -31-

<PAGE>



            (f) Written off any notes or accounts  receivable  as  uncollectible
      other then in the  ordinary  course of business and  consistent  with past
      practices;

            (g)  Discharged  or satisfied  any lien or  encumbrance  or paid any
      obligation  or  liability  (whether  absolute,   accrued,   contingent  or
      otherwise and whether due or to become due) other than current liabilities
      shown on the Alamar Balance Sheet and current liabilities  incurred in the
      ordinary course of business and consistent with past practice;

            (h) Sold, assigned,  transferred,  mortgaged,  pledged or encumbered
      any of its assets  (real,  personal  or mixed,  tangible  or  intangible),
      cancelled any debts or claims or waived any rights of  substantial  value,
      except,  in each case, in the ordinary  course of business and  consistent
      with past practice;

            (i) Sold,  assigned or transferred  any patents,  trademarks,  trade
      names,  copyrights  or other similar  assets,  including  applications  or
      licenses therefor;

            (j) Entered into any  transaction  other than in the ordinary course
      of business or otherwise contemplated by this Agreement; or

            (k)  Entered  into  any  agreement  or  commitment  to do any of the
      foregoing.

      5.27 Manufacturing,  Distribution and License Rights.  Except as disclosed
in  the  Alamar  Schedules,  Alamar  has  not  granted  rights  or  licenses  to
manufacture, assemble, distribute, license or sell its products to any person or
entity,  is not bound by any agreement that affects Alamar's  exclusive right to
manufacture,  assemble,  distribute,  license or sell Alamar's products, and has
not licensed or sold any of its technology or  Proprietary  Rights to any person
or entity.

      5.28  Customers  and  Distributors.  Except  as  disclosed  in the  Alamar
Schedules,  Alamar has no actual  knowledge that any customer or distributor has
ceased, or intends to cease,  utilizing or purchasing the goods or services,  or
distributing the products,  of Alamar or has substantially  reduced,  or intends
substantially to reduce,  the use or purchase of such goods or services,  or the
distribution of such products.

      5.29 Suppliers. Alamar has no actual knowledge that any supplier of Alamar
will not sell goods and services to Alamar at any time after the Effective  Time
on terms and  conditions  and in  quantities  similar to those of prior sales to
Alamar.

      5.30 Full Disclosure.  Alamar is not aware of any facts directly  relating
to its business or property (excluding,  without limitation,  any facts relating
to economic,  business,  political or industry  conditions  generally)  which it
believes  affect  materially  adversely  such  business  or property or which it
believes are likely in the future to affect  materially  adversely such business
or  property  which  have not been  disclosed  in this  Agreement  or the Alamar
Schedules or been otherwise disclosed in writing to AccuMed.


                                     -32-

<PAGE>



      5.31 No  Misrepresentation.  None of the representations and warranties of
Alamar set forth in this  Agreement  or in any of the  certificates,  schedules,
lists, documents,  exhibits, or other instruments delivered, or to be delivered,
to AccuMed as contemplated by any provision hereof, contains, or will contain at
the Effective  Time, any untrue  statement of a material fact or omits,  or will
omit at the Effective  Time,  any material fact necessary to make the statements
contained herein or therein not misleading.


                                  ARTICLE VI
               CONDUCT AND COVENANTS PRIOR TO THE EFFECTIVE TIME

      6.1 Conduct of Business. During the period from the date of this Agreement
and continuing  until the earlier of the termination of this Agreement  pursuant
to its terms and the Effective Time,  each of Alamar and AccuMed agrees,  except
to the extent  that the other party shall  otherwise  consent in writing  (which
consent shall not be unreasonably withheld or delayed), to carry on its business
in the usual,  regular and ordinary course in  substantially  the same manner as
heretofore conducted,  to pay its debts and taxes when due subject to good faith
disputes over such debts or taxes, to pay or perform other material  obligations
when due, and to use all commercially  reasonable  efforts  consistent with past
practices and policies to preserve  intact its present  business  organizations,
keep  available the services of its present  officers and employees and preserve
its relationships with customers, suppliers, distributors,  licensors, licensees
and others  having  business  dealings with it, to the end that its goodwill and
ongoing  businesses  be unimpaired  at the  Effective  Time.  Alamar and AccuMed
further  agree  that  each  shall  promptly  notify  the  other of any  event or
occurrence not in the ordinary  course of its business,  and will not enter into
or amend any agreement or take any action which  reasonably would be expected to
have a Material  Adverse Effect on it. Alamar further  covenants and agrees that
it will use its best efforts (a) to raise at least  $1,800,000 in gross proceeds
through the S Private  Placement  and/or D Private  Placement within 10 business
days of the date of this Agreement and (b) to maintain the listing of the Alamar
Common Stock on, and to meet all of the requirements  for continued  listing on,
the  Nasdaq  SmallCap  Market  or, if the Alamar  Common  Stock is removed  from
listing on the Nasdaq  SmallCap  Market,  to obtain the  relisting of the Alamar
Common  Stock on the  Nasdaq  SmallCap  Market or  another  national  securities
market. The parties are aware of the pending negotiations with Becton, Dickinson
& Company  ("BD") and each will cooperate and use their best efforts to complete
these  negotiations  successfully  in order to  obtain  additional  capital  for
Alamar.

      6.2  Consent  of Other  Party to  Engage  in  Certain  Conduct.  Except as
expressly contemplated by this Agreement or disclosed on the Alamar Schedules in
the case of Alamar and the AccuMed  Schedules  in the case of  AccuMed,  neither
Alamar nor Accumed shall prior to the Effective  Time or earlier  termination of
this Agreement  pursuant to its terms,  without the prior written consent of the
other party (which consent shall not be unreasonably withheld or delayed, and to
the extent Peter P.  Gombrich is consenting  on behalf of Alamar,  Mr.  Gombrich
will obtain the approval of Alamar's Board prior to giving such consent):


                                     -33-

<PAGE>



            (a)  Accelerate,  amend or change  the period of  exercisability  of
      options or restricted stock, or reprice options granted under the employee
      stock plans of such party or authorize  cash  payments in exchange for any
      options granted under any of such plans;

            (b) Grant any  severance  or  termination  pay (i) to any  executive
      officer or (ii) to any other employee  except  payments made in connection
      with the  termination  of  employees  who are not  executive  officers  in
      amounts  consistent  with such  party's  policies  and past  practices  or
      pursuant to written agreements  outstanding,  or policies existing, on the
      date hereof or pursuant to written agreements consistent with such party's
      prior agreements under similar circumstances;

            (c) Transfer or license to any person or entity or otherwise extend,
      amend or modify any  rights to such  party's  Proprietary  Rights or enter
      into grants to future  patent  rights,  other than  licenses in connection
      with the sale of goods or services  entered into in the ordinary course of
      business consistent with past practices;

            (d) Declare or pay any dividends on or make any other  distributions
      (whether  in cash,  stock or  property)  in respect of any of its  capital
      stock,  or split,  combine or reclassify any of its capital stock or issue
      or authorize  the issuance of any other  securities in respect of, in lieu
      of or in substitution for shares of capital stock of such party;

            (e) Repurchase or otherwise  acquire,  directly or  indirectly,  any
      shares of its capital  stock except from former  employees,  directors and
      consultants  in  accordance  with  written  agreements  providing  for the
      repurchase of shares in connection with any termination of service to such
      party;

            (f) Issue,  deliver or sell or  authorize  or propose the  issuance,
      delivery  or sale of any  shares  of its  capital  stock  of any  class or
      securities convertible into, or subscriptions, rights, warrants or options
      to acquire, or other agreements or commitments of any character obligating
      it to issue any such shares or other convertible  securities,  other than,
      in the case of Alamar, (i) shares of Alamar Common Stock issuable upon the
      exercise  of  previously  issued  Alamar  Warrants,  (ii) shares of Alamar
      Common  Stock  issuable  upon the exercise of options  previously  granted
      pursuant  to the 1990 Alamar  Option Plan and the 1992 Alamar  Option Plan
      and/or  (iii) no more  than an  aggregate  of  4,000,000  shares of Alamar
      Common  Stock  pursuant  to the S  Private  Placement  and  the D  Private
      Placement, provided that neither the S Private Placement nor the D Private
      Placement  is  conditioned  in any way upon the  continued  listing of the
      Alamar Common Stock on the Nasdaq SmallCap Market;

            (g)  Except as  otherwise  provided  for  herein,  cause,  permit or
      propose  any  amendments  to such  party's  Articles of  Incorporation  or
      Bylaws;


                                  -34-

<PAGE>



            (h) Acquire or agree to acquire by merging or consolidating with, or
      by purchasing any equity  interest in or a material  portion of the assets
      of, or by any other manner,  any business or any corporation,  partnership
      interest,  association or other business organization or division thereof,
      or otherwise  acquire or agree to acquire any assets  which are  material,
      individually or in the aggregate,  to the business of such party, or enter
      into any joint ventures,  strategic  partnerships or alliances or purchase
      any distributors;

            (i) Sell,  lease,  license,  encumber or otherwise dispose of any of
      such party's  properties or assets which are material,  individually or in
      the  aggregate,  to the  business  of such party,  except in the  ordinary
      course of business consistent with past practice;

            (j) Incur any  indebtedness  for borrowed money (other than ordinary
      course trade  payables or pursuant to existing  credit  facilities  in the
      ordinary  course of business) or guarantee any such  indebtedness or issue
      or sell  any debt  securities  or  warrants  or  rights  to  acquire  debt
      securities of such party or guarantee any debt securities of others;

            (k) Adopt or amend any employee  benefit or stock purchase or option
      plan,  or enter into any  employment  contract,  pay any special  bonus or
      special remuneration to any director or employee, or increase the salaries
      or wage  rates of its  employees  other  than in the  ordinary  course  of
      business, consistent with past practice;

            (l) Revalue any of its assets,  including  writing down the value of
      inventory  or writing off notes or accounts  receivable  other than in the
      ordinary course of business consistent with past practices;

            (m) Pay,  discharge or satisfy in an amount in excess of $10,000 (in
      any one case) or  $50,000  (in the  aggregate),  any claim,  liability  or
      obligation  (absolute,  accrued,  asserted or  unasserted,  contingent  or
      otherwise),  other than the  payment,  discharge  or  satisfaction  in the
      ordinary  course of  business  of  liabilities  of the type  reflected  or
      reserved  against  in such  party's  financial  statements  (or the  notes
      thereto)  (included in each of the AccuMed and Alamar  Schedules is a list
      of  accounts  payables as to which  AccuMed  and Alamar  agree there is no
      dispute and which may be paid down in the ordinary course);

            (n) Make or change any material election in respect of Taxes,  adopt
      or change any accounting method in respect of Taxes, file any material Tax
      Return or any  amendment to a material Tax Return,  enter into any closing
      agreement,  settle any claim or  assessment  in  respect of Taxes  (except
      settlements  effected solely through payment of immaterial sums of money),
      or consent to any extension or waiver of the limitation  period applicable
      to any claim or assessment in respect of Taxes;


                                  -35-

<PAGE>



            (o)  Commence  any  litigation   other  than  (i)  for  the  routine
      collection  of bills or (ii) in such case  where  such party in good faith
      determines in good faith that failure to commence suit would result in the
      material  impairment  of a  valuable  aspect  of  such  party's  business,
      provided that such party consults with the other party prior to the filing
      of such a suit; or

            (p) Take,  or agree in  writing  or  otherwise  to take,  any of the
      actions  described  in Sections  6.2(a)  through (o) above,  or any action
      which  would  cause or  would be  reasonably  likely  to cause  any of the
      conditions to the Merger set forth in Sections 8.1 or 8.2, with respect to
      Alamar,  or  Sections  8.1 or 8.3,  with  respect  to  AccuMed,  not to be
      satisfied.

      6.3  Bring-down  of  Disclosure  Schedules.  At the closing,  Alamar shall
deliver the Updated  Alamar  Schedules (as  hereinafter  defined) to AccuMed and
AccuMed shall deliver the Updated AccuMed Schedules (as hereinafter  defined) to
Alamar.


                                  ARTICLE VII
                             ADDITIONAL AGREEMENTS

      7.1 Proxy  Statement/Prospectus;  Registration  Statement.  As promptly as
practicable  after the execution of this  Agreement,  Alamar shall prepare,  and
file with the SEC, the Proxy Statement and the  Registration  Statement in which
the Proxy Statement will be included as a prospectus.  Alamar shall use its best
efforts to have the Registration Statement declared effective as soon thereafter
as practicable. The Proxy Statement shall also include the recommendation of the
Board of  Directors  of  Alamar  in  favor  of the  Merger  which  shall  not be
withdrawn,  modified or withheld except in compliance with the fiduciary  duties
of Alamar's Board under  applicable law. AccuMed shall cooperate with Alamar and
its agents in the preparation and efforts to achieve  effectiveness of the Proxy
Statement and Registration Statement.

      7.2 Meetings of  Shareholders.  Promptly  after the date  hereof,  AccuMed
shall take all action necessary in accordance with Illinois Law and its Articles
of  Incorporation  and Bylaws to convene a meeting of the  AccuMed  Shareholders
("AccuMed  Shareholders' Meeting") to be held as promptly as practicable for the
purpose of voting upon this  Agreement and the Merger.  Promptly  after the date
hereof, Alamar shall take all action necessary in accordance with California Law
and its Articles of Incorporation and Bylaws to convene the Alamar Shareholders'
Meeting to be held as  promptly  as  practicable  for the purpose of voting upon
this Agreement and the Merger.

      7.3   Access to Information; Confidentiality.

            (a) Each party  shall  afford the other  party and its  accountants,
      counsel and other representatives reasonable access during normal business
      hours during the period  prior to the  Effective  Time to all  information
      concerning  the  business,  including  the status of  product  development
      efforts,  properties  and  personnel  of such party as the other party may
      reasonably request. No information or

                                  -36-

<PAGE>



      knowledge obtained in any investigation pursuant to this Section 7.3 shall
      affect or be deemed to modify any  representation  or  warranty  contained
      herein or the  conditions to the  obligations of the parties to consummate
      the Merger.

            (b) The parties  acknowledge that Alamar and AccuMed have previously
      executed a  Confidentiality  Disclosure  Agreement dated December 20, 1994
      (the "Confidentiality  Agreement"),  which Confidentiality Agreement shall
      continue in full force and effect in accordance with its terms.

      7.4   No Solicitation; Exclusivity.

            (a) Except for the  completion of the ongoing  negotiations  with BD
      with respect to licensing ,certain  Proprietary Rights of Alamar,  neither
      Alamar  nor  AccuMed  nor  any  of  their   subsidiaries,   affiliates  or
      representatives  shall,  directly  or  indirectly,   encourage,   solicit,
      participate in, initiate or continue  discussions or negotiations with, or
      provide any  information  to, any Person (other than any of the parties to
      this Agreement and their  subsidiaries,  affiliates  and  representatives)
      concerning any merger,  sale of assets, sale of shares of capital stock or
      similar transactions  involving any of the parties to this Agreement,  and
      any existing  discussions  or  negotiations  with third  persons  relating
      thereto shall be terminated immediately.

            (b) Nothing  contained in this Section 7.4 shall  prevent  Alamar or
      its Board of Directors from complying with the provisions of Rule 14e-2(a)
      and 14d-9 promulgated under the Exchange Act.

      7.5  Expenses.  Except  as set  forth in this  Section  7.5,  all fees and
expenses  incurred by the parties  hereto in connection  with this Agreement and
the transactions  contemplated  hereby shall be paid by the party incurring such
expenses;  provided,  however, that upon consummation of the Merger all fees and
expenses  incurred  in  connection  with  this  Agreement  and the  transactions
contemplated  hereby,  including  all fees and  expenses  incurred  prior to the
consummation  of the  Merger,  shall  be paid  or  reimbursed  by the  Surviving
Corporation.

      7.6 Public  Disclosure.  Alamar and AccuMed  shall consult with each other
before issuing any press release or otherwise  making any public  statement with
respect  to the  Merger or this  Agreement  and  shall not issue any such  press
release or make any such public statement prior to such consultation,  except as
may be  required  by law or any  listing  agreement  with a national  securities
exchange or The Nasdaq  Stock  Market.  In the event any such  disclosure  would
violate  the terms of the  Confidentiality  Agreement,  Alamar will use its best
efforts to secure  confidential  treatment with respect to information for which
such treatment is available.

      7.7 FIRPTA.  Alamar shall deliver to the Internal Revenue Service a notice
that the Alamar Common Stock is not a "U.S.  Real Property  Interest" as defined
in and in  accordance  with the  requirements  of  Treasury  Regulation  Section
1.897-2(h)(2).


                                     -37-

<PAGE>



      7.8  Legal  Requirements.  Each  of  Alamar  and  AccuMed  will  take  all
reasonable  actions  necessary or desirable  to comply  promptly  with all legal
requirements  which may be imposed on them with respect to the  consummation  of
the  transactions  contemplated  by this  Agreement  (including  furnishing  all
information  required under and in connection  with approvals of or filings with
any  Governmental  Entity,  and prompt  resolution  of any  litigation  prompted
hereby) and will promptly  cooperate  with and furnish  information to any party
hereto  necessary in connection with any such  requirements  imposed upon any of
them or their respective subsidiaries in connection with the consummation of the
transactions  contemplated  by this  Agreement,  and will  take  all  reasonable
actions necessary to obtain (and will cooperate with the other parties hereto in
obtaining)  any  consent,   approval,   order  or   authorization   of,  or  any
registration,  declaration  or filing  with,  any  Governmental  Entity or other
public or private third party required to be obtained or made in connection with
the Merger or taking of any action contemplated by this Agreement.

      7.9 Blue Sky Laws.  Alamar  shall take such steps as may be  necessary  to
comply  with the  securities  and blue sky laws of all  jurisdictions  which are
applicable to the issuance of Alamar Common Stock pursuant hereto. AccuMed shall
use its best  efforts to assist  Alamar as may be  necessary  to comply with the
securities  and blue sky  laws of all  jurisdictions  which  are  applicable  in
connection with the issuance of Alamar Common Stock pursuant hereto.

      7.10 Best  Efforts  and  Further  Assurances.  Each of the parties to this
Agreement shall use its best efforts to effectuate the transactions contemplated
hereby and to fulfill and cause to be fulfilled the  conditions to closing under
this Agreement  (including  resolution of any litigation prompted hereby).  Each
party hereto, at the reasonable  request of another party hereto,  shall execute
and deliver such other instruments and do and perform such other acts and things
as may be necessary or desirable for effecting  completely the  consummation  of
the transactions contemplated hereby.

      7.11 Certain Benefit Plans.  Alamar shall take such reasonable  actions as
are  necessary  to allow  eligible  employees of AccuMed to  participate  in the
benefit  programs  of Alamar,  or  alternative  benefit  programs  substantially
comparable to those  applicable to employees of Alamar on similar terms, as soon
as  practicable  after the Effective  Time in accordance  with the terms of such
programs. To the extent reasonably possible, eligible employees of AccuMed shall
receive credit under any new benefit  program (other than  sabbatical  programs)
for the duration of their service with AccuMed.

      7.12  Officer and Director Indemnification.

            (a)  After the  Effective  Time,  the  Surviving  Corporation  shall
      indemnify  and hold  harmless each person who has at any time prior to the
      Effective  Time been an officer,  director or employee of AccuMed or other
      person  entitled to be indemnified by AccuMed  pursuant to its Articles of
      Incorporation  and  Bylaws  as they are  currently  in  effect on the date
      hereof to the same extent as provided  in such  Articles of  Incorporation
      and Bylaws;  provided that it is understood that the foregoing undertaking
      shall not grant to any such  officers,  directors  or  employees  or other
      person rights of indemnity against Surviving

                                  -38-

<PAGE>



      Corporation  more  extensive  than those such persons may  currently  have
      against AccuMed.

            (b)  After the  Effective  Time,  the  Surviving  Corporation  shall
      indemnify the persons who  immediately  prior to the  Effective  Time were
      directors  or officers of AccuMed  against all actions,  claims,  damages,
      costs,  expenses,  liabilities  or  judgments  or amounts that are paid in
      settlement with the approval of the indemnifying party of or in connection
      with any claim, action,  suit,  proceeding or investigation based in whole
      or in part on or  arising  in whole or in part out of the fact  that  such
      person is or was a director  or officer  of  AccuMed,  in each case to the
      full extent a corporation is permitted  under  California Law to indemnify
      its own directors and officers  (and the  Surviving  Corporation  will pay
      expenses in advance of the final disposition of any such actual proceeding
      to each indemnified party to the full extent permitted by California Law).
      In connection with such  indemnification,  (x) any counsel retained by the
      indemnified  parties  for any  period  after the  Effective  Time shall be
      satisfactory to the Surviving  Corporation,  (y) after the Effective Time,
      the Surviving  Corporation  shall pay the reasonable  fees and expenses of
      such counsel,  promptly after statements therefor are received and (z) the
      Surviving  Corporation  will  cooperate in the defense of any such matter,
      provided,  that the  Surviving  Corporation  shall not be  liable  for any
      settlement  effected without their prior written consent.  The indemnified
      parties as a group may  retain  only one law firm to  represent  them with
      respect to any single action unless there is, under  applicable  standards
      of professional  conduct,  a conflict on any significant issue between the
      positions of any two or more indemnified parties.

            (c) For a period  of three  years  after  the  Effective  Time,  the
      Surviving Corporation shall use its best efforts to maintain in effect, if
      available,  directors' and officers'  liability  insurance  covering those
      persons  who are  currently  directors  and  officers  of AccuMed on terms
      comparable to those applicable to the then current  directors and officers
      of Alamar.

            (d) This Section shall survive the  consummation  of the Merger,  is
      intended to benefit the indemnified  parties,  and shall be binding on all
      successors and assigns of the Surviving Corporation.

      7.13 Affiliate Agreements. Set forth in the AccuMed Schedules is a list of
those persons who are, in AccuMed's reasonable judgment  "Affiliates" of AccuMed
within  the  meaning  of Rule 145 (each such  person  who is an  "affiliate"  of
AccuMed  within  the  meaning  of Rule  145 is  referred  to as an  "Affiliate")
promulgated under the Securities Act ("Rule 145").  AccuMed shall provide Alamar
with such  information  and  documents  as Alamar shall  reasonably  request for
purposes of reviewing  such list.  AccuMed shall use its best efforts to deliver
or cause to be  delivered  to Alamar,  concurrently  with the  execution of this
Agreement,  from  each of the  Affiliates  of  AccuMed,  an  executed  Affiliate
Agreement in the form attached  hereto as Exhibit B (each an "AccuMed  Affiliate
Agreement"  collectively,  the "AccuMed Affiliate Agreements").  Alamar shall be
entitled to place appropriate legends on the certificates  evidencing any Alamar
Common Stock to be received by such Affiliates of AccuMed pursuant

                                     -39-

<PAGE>



to  the  terms  of  this  Agreement,  and to  issue  appropriate  stop  transfer
instructions to the transfer agent for Alamar Common Stock,  consistent with the
terms of the AccuMed Affiliate Agreements.

      7.14  Migratory  Merger to Delaware;  Name Change.  Immediately  after the
Effective Time, the Surviving Corporation shall, for the purpose of changing the
domicile of the Surviving  Corporation  from California to Delaware and changing
the  name of the  Surviving  Corporation  from  "Alamar  Biosciences,  Inc."  to
"AccuMed International, Inc.", merge with and into a Delaware corporation having
the identical  characteristics  of the  "Surviving  Corporation"  except that it
shall have the name  "AccuMed  International,  Inc." Such  Delaware  corporation
shall  thereafter  be  deemed,  for  the  purposes  of  this  Agreement  and the
transactions  contemplated  hereby,  the  "Surviving  Corporation".  Alamar will
obtain the consent of their  shareholders  to such change in corporate  domicile
and will take all other  actions  necessary  to effect such change in  corporate
domicile.

      7.15  Intentionally Deleted.

      7.16  Tax-Free  Reorganization.  Alamar  and  AccuMed  shall  each use all
reasonable efforts to cause the Merger to be treated as a reorganization  within
the meaning of Section 368 of the Code.

      7.17  Interim Management.

            (a) As of the  date  of  this  Agreement,  Alamar  shall  turn  over
      management  control of Alamar to Peter P. Gombrich  ("Gombrich") who shall
      serve as acting Chief Executive Officer with full authority as provided to
      the Chief Executive Officer under Alamar's Bylaws,  including the full and
      absolute  authority to disburse Alamar funds. In  consideration  therefor,
      Alamar  shall pay  Gombrich  at the rate of $12,500  per month  during the
      period from the date hereof until the Effective Time.  Gombrich  expressly
      agrees and  acknowledges  that by assuming  the  position of acting  Chief
      Executive Officer, Gombrich will incur fiduciary duties and obligations to
      Alamar's  shareholders  consistent  with the  position of Chief  Executive
      Officer.  Gombrich  agrees to maintain from the date hereof to the Closing
      Date the  distinction,  separateness and integrity of Alamar as a separate
      corporation and entity and agrees not to commingle funds or assets.  If at
      any time a  conflict  arises  between  Gombrich's  duties to Alamar and to
      AccuMed,  Gombrich will  immediately  advise  Alamar's Board of Directors,
      which will relieve  Gombrich of his obligations  with respect to Alamar to
      the  extent  necessary  to  alleviate  the  conflict.  In the  event  this
      Agreement is  terminated as provided  herein prior to the Effective  Time,
      Gombrich will resign as acting Chief Executive  Officer  immediately after
      such termination.

            (b) As of the  date  of  this  Agreement  all  of  Alamar's  current
      Directors  who will not  serve on the  Interim  Board as set forth in this
      Section  7.17(b) shall resign.  From and after the date of this  Agreement
      until the  Closing  Date (the  "Interim  Period"),  Alamar  shall take all
      actions  necessary  to cause its  Board to be  composed  of the  following
      persons  (each  an  "Interim  Director"  and  collectively,  the  "Interim
      Board"):


                                     -40-

<PAGE>



                  (1)   Gombrich;

                  (2)   Jack Halperin;

                  (3)   Richard Corbin;

                  (4)   Len Schiller;

                  (5)   John Abeles; and

                  (6)   Don Earhart.

            (c) During the  Interim  Period,  the  Interim  Board shall take all
      actions necessary to create an "Expenses  Committee",  which shall consist
      of Jack  Halperin,  Richard  Corbin and Len  Schiller and which during the
      Interim Period shall approve all (i)  expenditures by Alamar of $25,000 or
      more and (ii) capital  expenditures  by Alamar of $5,000 or more ("capital
      expenditures"  for purposes hereof,  shall means any expenditure  which is
      required by GAAP to be capitalized  and which appears on Alamar's  balance
      sheet in the category of property, plant or equipment).

            (d) In the event this  Agreement is  terminated  as provided  herein
      prior  to the  Closing,  Gombrich  will  resign  from  the  Interim  Board
      immediately after such termination.

      7.18 Board Representation Upon Closing.  Immediately after the Closing the
Interim  Directors  who will not  continue to serve on the Board as set forth in
this Section 7.18 will resign.  The Surviving  Corporation will take all actions
necessary to cause,  immediately after the Closing, (i) the number of members of
its Board of  Directors  to be seven and (ii) such Board to be  composed  of the
following persons, each of whom shall serve for a term of two years:

            (a)   Gombrich, who shall serve as Chairman;

            (b)  Two   individuals   (together  with   Gombrich,   the  "AccuMed
      Nominees"), who will be selected by AccuMed;

            (c) Three individuals  (collectively,  the "Alamar  Nominees"),  who
      will be selected jointly by Commonwealth Associates and American Equities;
      and

            (d) one person  designated  and  nominated by mutual  consent of the
      AccuMed Nominees and the Alamar Nominees.

      In the event that this  Agreement  is  terminated  as provided  herein and
Gombrich and the AccuMed  Nominees  shall have been elected to Alamar's Board of
Directors pursuant to this Section 7.18, Gombrich and the AccuMed Nominees shall
resign from Alamar's Board of Directors immediately after such termination.


                                     -41-

<PAGE>



      7.19  Alamar  Interim  Loan to AccuMed.  On the date at least  $650,000 in
gross proceeds are received by Alamar pursuant to the S Private Placement and/or
the D Private Placement,  which shall be no later than seven business days after
the date of this  Agreement,  Alamar shall loan the principal sum of $150,000 to
AccuMed  which loan shall be  evidenced by a  promissory  note in the  principal
amount of $150,000 repayable by AccuMed,  with 10% per annum interest, to Alamar
on December 31, 1995, which promissory note shall be convertible into 51% of the
capital stock of AccuMed,  at the election of the holder thereof,  if not repaid
on or prior to December 31, 1995.


                                 ARTICLE VIII
                           CONDITIONS TO THE MERGER

      8.1  Conditions  to  Obligations  of Each Party to Effect the Merger.  The
respective  obligations  of each  party to this  Agreement  to effect the Merger
shall be subject to the satisfaction at or prior to the Closing of the following
conditions:

            (a) Shareholder  Approval.  This Agreement and the Merger shall have
      been approved and adopted by the requisite  vote under  applicable  law of
      the shareholders of each of AccuMed and Alamar.

            (b) Registration  Statement  Effective.  The SEC shall have declared
      the  Registration  Statement  effective.  No  stop  order  suspending  the
      effectiveness of the Registration Statement or any part thereof shall have
      been issued and no proceeding for that purpose,  and no similar proceeding
      in respect of the Proxy Statement, shall have been initiated or threatened
      in writing by the SEC; and all requests for additional  information on the
      part  of  the  SEC  shall  have  been  complied  with  to  the  reasonable
      satisfaction of the parties hereto.

            (c) No  Injunctions;  illegality.  No temporary  restraining  order,
      preliminary or permanent  injunction or other order issued by any court of
      competent   jurisdiction  or  other  legal  or  regulatory   restraint  or
      prohibition preventing the consummation of the Merger shall be in effect.

            (d) Tax  Opinions.  Alamar  and  AccuMed  shall  each have  received
      substantially  identical  written  opinions from their  counsel,  Graham &
      James  and  Katten  Muchin & Zavis,  respectively,  in form and  substance
      reasonably  satisfactory  to them,  to the  effect  that the  Merger  will
      constitute a  reorganization  within the meaning of Section  368(a) of the
      Code.   The   parties  to  this   Agreement   agree  to  make   reasonable
      representations  as requested by such counsel for the purpose of rendering
      such opinions.

            (e)  Nasdaq  Listing.  If as of the  Closing  Date  shares of Alamar
      Common  Stock are  listed on the  Nasdaq  SmallCap  Market,  the shares of
      Alamar Common Stock issuable to the AccuMed Shareholders  pursuant to this
      Agreement  shall have been  authorized for listing on the Nasdaq  SmallCap
      Market upon official notice of issuance.

                                  -42-

<PAGE>




      8.2 Additional  Conditions to Obligations of AccuMed.  The  obligations of
AccuMed  to  consummate   and  effect  this   Agreement  and  the   transactions
contemplated  hereby  shall be  subject to the  satisfaction  at or prior to the
Effective Time of each of the following conditions,  any of which may be waived,
in writing, exclusively by AccuMed:

            (a)   Representations   and  Warranties.   The  representations  and
      warranties of Alamar contained in this Agreement shall be true and correct
      in all  material  respects  on and as of the  Effective  Time,  except for
      changes   contemplated   by  this   Agreement   and   except   for   those
      representations  and  warranties  which  address  matters  only  as  of  a
      particular  date  (which  shall  remain true and correct as of such date),
      with the same force and effect as if made on and as of the Effective Time,
      except, in all such cases, for such breaches, inaccuracies or omissions of
      such  representations and warranties which have neither had nor reasonably
      would be expected  to have a Material  Adverse  Effect on Alamar,  and the
      Alamar Schedules shall be updated (the "Updated Alamar Schedules") through
      the Effective Time to reflect any changes in Alamar's  representations and
      warranties;

            (b)  Agreements  and  Covenants.  Alamar  shall  have  performed  or
      complied  in all  material  respect  with  all  agreements  and  covenants
      required by this  Agreement to be  performed or complied  with by it on or
      prior to the Effective Time;

            (c) Third Party  Consents.  AccuMed  shall have received all written
      consents,  assignments,  waivers,  authorizations  or  other  certificates
      reasonably  deemed necessary by AccuMed's legal counsel to provide for the
      continuation  in full  force  and  effect of any and all  material  Alamar
      Contracts  and  Permits  and for  Alamar to  consummate  the  transactions
      contemplated hereby, except where the failure to receive any such consent,
      assignment,  waiver,  authorization or other  certificate would not have a
      Material Adverse Effect on Alamar.

            (d) Legal Opinion.  AccuMed shall have received a legal opinion from
      Graham & James,  counsel  to  Alamar,  in form  and  substance  reasonably
      acceptable to AccuMed.

            (e)  Employment  Agreements.  Alamar shall have executed  Employment
      Agreements,  in form  and  substance  reasonably  acceptable  to  AccuMed,
      Alamar,   Gombrich  and,  with  respect  to  severance   provisions  only,
      Commonwealth  (the "Employment  Agreements"),  with Gombrich and the other
      key employees listed on the AccuMed Schedules ("Key Employees"),  and such
      Employment  Agreements  shall be in full force and effect.  The Employment
      Agreement  between  Alamar and Gombrich shall provide for a base salary of
      at least  $150,000  per  year  and  shall  include  appropriate  severance
      provisions.

            (f) Funding  Requirements.  AccuMed shall have been  furnished  with
      evidence  satisfactory to it that Alamar has received at least  $1,800,000
      in gross  proceeds  from the S  Private  Placement  and/or  the D  Private
      Placement.

                                  -43-

<PAGE>




            (g) Legal Due  Diligence.  No later then the end of the  AccuMed Due
      Diligence  Period (as defined  below) Alamar shall have made  available to
      AccuMed a true, accurate and complete copy of each written Alamar Contract
      (together with all amendments and addendum thereto),  a true, accurate and
      complete description of each oral Alamar Contract and a true, accurate and
      complete  copy of any other  document  reasonably  requested by AccuMed in
      connection  with  its  legal  due  diligence  investigation  (the  "Alamar
      Documents")  and  AccuMed  shall have  completed  its legal due  diligence
      investigation  of  Alamar  and  review  of the  Alamar  Documents,  to its
      reasonable  satisfaction during the period of fourteen (14) days after the
      date hereof (the  "AccuMed  Due  Diligence  Period");  provided  that this
      condition  shall be deemed  satisfied in full if within  twenty-four  (24)
      hours of the end of the AccuMed Due  Diligence  Period  AccuMed  shall not
      have  given  Alamar  written  notice  stating  that  AccuMed's  legal  due
      diligence  investigation  of Alamar  and  review of the  Alamar  Documents
      indicates  the  existence  of facts and  circumstances  which would have a
      Material  Adverse  Effect  on  Alamar  or the  Surviving  Corporation  and
      specifying in reasonable detail the factual basis therefor.  To the extent
      that any of the Alamar Documents or any information  reasonably  requested
      by AccuMed in connection with its due diligence investigation of Alamar is
      not  delivered to AccuMed  within seven (7) days of the date hereof,  then
      the expiration date of the AccuMed Due Diligence  Period shall be extended
      one (1) day for each day that such  delivery is delayed.  In addition,  if
      the date upon which the  AccuMed  Due  Diligence  Period  would  otherwise
      expire shall fall on a date that is not a business  day, the next business
      day following such  non-business  day shall be the expiration  date of the
      Due Diligence Period.

      8.3 Additional Conditions to the Obligations of Alamar. The obligations of
Alamar to consummate and effect this Agreement and the transactions contemplated
hereby shall be subject to the satisfaction at or prior to the Effective Time of
each of the  following  conditions,  any of which  may be  waived,  in  writing,
exclusively by Alamar:

            (a)   Representations   and  Warranties.   The  representations  and
      warranties  of  AccuMed  contained  in this  Agreement  shall  be true and
      correct in all material  respects on and as of the Effective Time,  except
      for  changes   contemplated   by  this  Agreement  and  except  for  those
      representations  and  warranties  which  address  matters  only  as  of  a
      particular  date  (which  shall  remain true and correct as of such date),
      with the same force and effect as if made on and as of the Effective Time,
      except, in all such cases, for such breaches, inaccuracies or omissions of
      such  representations and warranties which have neither had nor reasonably
      would be expected to have a Material  Adverse  Effect on AccuMed,  and the
      AccuMed Schedules shall be updated ("Updated AccuMed  Schedules")  through
      the Effective Time to reflect any changes in AccuMed's representations and
      warranties;

            (b)  Agreement  and  Covenants.  AccuMed  shall  have  performed  or
      complied  in all  material  respects  with all  agreements  and  covenants
      required by

                                  -44-

<PAGE>



      this Agreement to be performed or complied with by it on or prior to the
      Effective Time;

            (c) Third Party  Consents.  Alamar  shall have  received all written
      consents,  assignments,  waivers,  authorizations  or  other  certificates
      reasonably  deemed  necessary by Alamar's legal counsel to provide for the
      continuation  in full  force and  effect of any and all  material  AccuMed
      Contracts  and  Permits  and for AccuMed to  consummate  the  transactions
      contemplated  hereby except where the failure to receive any such consent,
      assignment,  waiver,  authorization or other  certificate would not have a
      Material Adverse Effect on Alamar.

            (d) Legal  Opinion.  Alamar shall have received a legal opinion from
      Katten  Muchin & Zavis,  legal  counsel to AccuMed,  in form and substance
      reasonably acceptable to Alamar.

            (e) Employment  Agreements.  Peter P. Gombrich and the Key Employees
      shall  have  executed  the  Employment  Agreements,   and  the  Employment
      Agreements shall be in full force and effect.

            (f) Affiliate Agreements.  Each of the parties identified by AccuMed
      pursuant to Section  7.13 hereof as being an  Affiliate  of AccuMed  shall
      have delivered to Alamar an executed AccuMed  Affiliate  Agreement,  which
      shall be in full force and effect.

            (g) Legal Due  Diligence.  No later  then the end of the  Alamar Due
      Diligence  Period (as defined  below) AccuMed shall have made available to
      Alamar a true, accurate and complete copy of each written AccuMed Contract
      (together with all amendments and addendum thereto),  a true, accurate and
      complete  description of each oral AccuMed  Contract and a true,  accurate
      and complete copy of any other document reasonably  requested by Alamar in
      connection  with its  legal  due  diligence  investigation  (the  "AccuMed
      Documents")  and  Alamar  shall  have  completed  its legal due  diligence
      investigation  of AccuMed  and  review of the  AccuMed  Documents,  to its
      reasonable  satisfaction during the period of fourteen (14) days after the
      date  hereof (the  "Alamar  Due  Diligence  Period");  provided  that this
      condition  shall be deemed  satisfied in full if within  twenty-four  (24)
      hours of the end of the Alamar Due Diligence  Period Alamar shall not have
      given AccuMed  written  notice  stating that Alamar's  legal due diligence
      investigation of AccuMed and review of the AccuMed Documents indicates the
      existence of facts and  circumstances  which would have a Material Adverse
      Effect  on  AccuMed  or  the  Surviving   Corporation  and  specifying  in
      reasonable  detail the factual basis  therefor.  To the extent that any of
      the AccuMed Documents or any information reasonably requested by Alamar in
      connection  with  its  due  diligence  investigation  of  AccuMed  is  not
      delivered to Alamar  within  seven (7) days of the date  hereof,  then the
      expiration  date of the Alamar Due Diligence  Period shall be extended one
      (1) day for each day that such  delivery is delayed.  In addition,  if the
      date upon which the Alamar Due  Diligence  Period would  otherwise  expire
      shall fall on a date that is not a business

                                  -45-

<PAGE>



      day, the next business day following  such  non-business  day shall be the
      expiration date of the Due Diligence Period.

            (h) Indebtedness.  AccuMed shall not have aggregate  liabilities for
      borrowed money, evidenced by notes, debentures or similar instruments,  in
      excess of  $825,000  (which  shall not include  indebtedness  to Alamar or
      Commonwealth incurred after the date of this Agreement).


                                  ARTICLE IX
                      TERMINATION, AMENDMENT AND WAIVER

      9.1 Termination. This Agreement may be terminated and the Merger abandoned
at any time prior to the Effective Time:

            (a)   by mutual written consent of AccuMed and Alamar;

            (b)   by Alamar if:

                  (i) there has been a  material  breach of any  representation,
            warranty, covenant or agreement,  contained in this Agreement on the
            part of  AccuMed  and such  breach  has not been  cured  within  ten
            business days after written notice to AccuMed (provided, that Alamar
            is not in  material  breach  of the  terms  of this  Agreement;  and
            provided further, that no cure period shall be required for a breach
            which by its nature  cannot be cured) such that the  conditions  set
            forth in Section 8.3(a) or Section 8.3(b),  as the case may be, will
            not be satisfied; or

                 (ii) the  Board  of  Directors  of  AccuMed  adversely  amends,
            withholds or withdraws its  recommendation  of the Merger  (provided
            that  Alamar  is  not  in  material  breach  of the  terms  of  this
            Agreement);

                (iii)  AccuMed's  shareholders  do not approve the Merger at the
            AccuMed Shareholders' Meeting;

            (c)      by AccuMed if:

                  (i) there has been a  material  breach of any  representation,
            warranty, covenant or agreement,  contained in this Agreement on the
            part of the  Alamar and such  breach  has not been cured  within ten
            days after written notice to Alamar  (provided,  that AccuMed is not
            in  material  breach of the terms of this  Agreement;  and  provided
            further, that no cure period shall be required for a breach which by
            its nature cannot be cured) such that the

                               -46-

<PAGE>



            conditions  set forth in Section 8.2(a) or Section  8.2(b),  as the
            case may be, will not be satisfied;

                 (ii)  the  Board  of  Directors  of  Alamar  adversely  amends,
            withholds  or  withdraws  its  recommendation  of the  Merger or the
            Merger is not submitted to Alamar's  shareholders as contemplated by
            this Agreement  (provided that AccuMed is not in material  breach of
            the terms of this Agreement); or

                (iii)  Alamar's  shareholders  do not  approve the Merger at the
            Alamar Shareholders' Meeting;

            (d)  by  any  party   hereto  if:  (i)  there   shall  be  a  final,
      non-appealable  order of a federal  or state  court in  effect  preventing
      consummation of the Merger; or (ii) there shall be any final action taken,
      or any statute,  rule, regulation or order enacted,  promulgated or issued
      or deemed applicable to the Merger by any Governmental  Entity which would
      make  consummation of the Merger illegal or which would prohibit  Alamar's
      ownership  or  operation  of all or a material  portion of the business of
      AccuMed, or compel Alamar to dispose of or hold separate all or a material
      portion of the  business or assets of AccuMed or Alamar as a result of the
      Merger;

            (e)  by  any  party  hereto  if  the  Merger  shall  not  have  been
      consummated  by December 31, 1995;  provided,  further,  that the right to
      terminate this Agreement  under this Section 9.1(e) shall not be available
      to any party  whose  willful  failure to fulfill any  material  obligation
      under this Agreement has been the cause of, or resulted in, the failure of
      the Effective Time to occur on or before such date;

Where action is taken to terminate this Agreement  pursuant to this Section 9.1,
it  shall be  sufficient  for  such  action  to be  authorized  by the  Board of
Directors (as applicable) of the party taking such action.

      9.2 Effect of  Termination.  In the event of termination of this Agreement
as provided in Section 9.1, this Agreement shall forthwith become void and there
shall be no  liability  or  obligation  on the part of Alamar,  AccuMed or their
respective officers, directors, shareholders or affiliates, except to the extent
that such  termination  results  from the breach by a party hereto of any of its
representations,   warranties,   covenants  or  agreements  set  forth  in  this
Agreement,  and,  provided that the  provisions of Sections  7.3(b) and 7.5, and
Article XI of this  Agreement  shall remain in full force and effect and survive
any termination of this Agreement.

      9.3 Notice of Termination. Any termination of this Agreement under Section
9.1 above will be effective  immediately  upon the delivery of written notice of
the terminating party to the other parties hereto.

      9.4 Amendment.  This Agreement may be amended by the parties hereto at any
time by execution of an  instrument  in writing  signed on behalf of each of the
parties hereto.

                                     -47-

<PAGE>




      9.5 Extension;  Waiver.  At any time prior to the Effective Time any party
hereto  may,  to the  extent  legally  allowed,  (i)  extend  the  time  for the
performance of any of the obligations or other acts of the other parties hereto,
(ii) waive any inaccuracies in the  representations  and warranties made to such
party contained  herein or in any document  delivered  pursuant hereto and (iii)
waive  compliance  with any of the  agreements or conditions  for the benefit of
such party contained herein.  Any agreement on the part of a party hereto to any
such  extension or waiver shall be valid only if set forth in an  instrument  in
writing signed on behalf of such party.


                                  ARTICLE X
                                  DEFINITIONS

      10.1 Definitions. For purposes of this Agreement, the following terms have
the meaning set forth below:

      "Alamar  Private  Warrants"  means the  1,368,059  warrants  issued to the
Persons,  in the amounts,  at the times and with the expiration dates, listed in
the Alamar Schedules.

      "Alamar Public  Warrants" means the 2,702,905  publicly  issued  warrants,
with an exercise price of $5.00 and an expiration date of October 15, 1997.

      "Alamar Warrants" means the Alamar Private Warrants and the Alamar Public
Warrants.

      "American Equities" means American Equities Overseas, Inc.

      "COBRA"  means  limited  continued  medical  benefit  coverage  for former
employees,  their spouses and other  dependents as required to be provided under
Section 4980B of the Code and Part 6 of Subtitle B of ERISA and the accompanying
proposed regulations or state continuation coverage laws.

      "Commonwealth"   means  Commonwealth   Associates,   a  New  York  limited
partnership.

      "D  Private  Placement"  means the  issuance  and sale by Alamar of Alamar
Common  Stock at a price of $0.625 per share  pursuant to a Regulation D Private
Placement conducted by Commonwealth commencing on or after the date hereof.

      "EEOC" means the United States Equal Employment Opportunity Commission.

      "Environmental and Safety Requirements" means all federal, state and local
statutes,  laws,  rules,  regulations,  codes,  ordinances,  orders,  standards,
permits,  licenses,   actions,  policies  and  requirements  (including  consent
decrees,  judicial decisions and administrative  orders) relating to protection,
preservation  or conservation of the environment and public or worker health and
safety, all as amended, hereafter amended or reauthorized.

      "ERISA" means the Employment  Retirement  Income  Security Act of 1974, as
amended.

                                     -48-

<PAGE>




      "Exchange Act" means the Securities Exchange Act of 1934, as amended.

      "Fair  Market   Value"  of  the  Alamar  Common  Stock  or  the  Surviving
Corporation  Common Stock (in either  case,  the "ASC Common  Stock")  means the
value  determined on the basis of the good faith  determination  of the Board of
Directors of Alamar or the Surviving  Corporation,  as the case may be,  without
regard to whether the ASC Common Stock is  restricted  or  represents a minority
interest, pursuant to the applicable method described below:

            (a) if the ASC  Common  Stock is  listed  on a  national  securities
      exchange or quoted on The Nasdaq Stock Market ("NASDAQ"),  the closing (or
      last) bid price of the ASC Common Stock on the relevant  date (or, if such
      date is not a business day or a day on which quotations are reported, then
      on the immediately  preceding date on which quotations were reported),  as
      reported  by the  principal  national  exchange  on which such  shares are
      traded (in the case of an exchange) or by NASDAQ, as the case may be;

            (b) if the  Common  Stock is not  listed  on a  national  securities
      exchange   or  quoted  on   NASDAQ,   but  is   actively   traded  in  the
      over-the-counter market, the closing bid price for the ASC Common Stock on
      the  relevant  date,  or the most  recent  preceding  date for which  such
      quotations are reported; or

            (c) if, on the relevant  date,  the ASC Common Stock is not publicly
      traded or reported as  described in (a) or (b),  the value  determined  in
      good  faith  by  the  Board  of  Directors  of  Alamar  or  the  Surviving
      Corporation, as the case may be.

      "GAAP" means  generally  accepted  accounting  principles set forth in the
opinions and  pronouncements of the Accounting  Principles Board of the American
Institute of Certified Public  Accountants and statements and  pronouncements of
the Financial  Accounting  Standards Board (or any successor authority) that are
applicable as the date of determination, consistently applied.

      "Governmental  Entity"  means any court,  arbitrator,  department,  board,
bureau, public authority,  administrative agency or commission or other foreign,
federal,  state,  municipal or other governmental  authority or instrumentality,
including the U.S. Food and Drug Administration and the California Department of
Health Services, Food and Drug Branch.

      "Hazardous Wastes" means: (A) hazardous materials,  hazardous  substances,
extremely  hazardous  substances or hazardous wastes, as those terms are defined
by the Comprehensive Environmental Response,  Compensation and Liability Act, 42
U.S.C.  ss.9601 et seq., the Resource  Conservation  and Recovery Act, 42 U.S.C.
ss.6901  et seq.,  and any other  Environmental  and  Safety  Requirements;  (B)
petroleum,  including  crude  oil or any  fraction  thereof  which is  liquid at
standard  conditions of temperature and pressure (60 degrees Fahrenheit and 14.7
pounds per square inch absolute);  (C) any radioactive  material,  including any
source,  special nuclear, or by-product material as defined in 42 U.S.C. ss.2011
et seq.; (D) asbestos in any form or condition;  (E) polychlorinated  biphenyls;
and (F) any other  material,  substance or waste to which liability or standards
of conduct may be imposed under any Environmental and Safety Requirements.

                                     -49-

<PAGE>




      "Laws" means all laws, statutes, codes, ordinances, rules, regulations and
orders of Governmental Entities.

      "material"  means  material to the  condition  (financial  or  otherwise),
properties, assets, liabilities, businesses, operations or results of operations
of AccuMed and its  subsidiaries,  taken as a whole, or Alamar,  as the case may
be.

      "Material Adverse Effect" means a material adverse effect on the business,
assets (including  intangible assets),  condition  (financial or otherwise),  or
results of operations of a party.

      "Permits" means all permits  (including  environmental,  construction  and
operation permits), licenses, notifications,  variances, exemptions, franchises,
certificates,  classifications,   registrations,  orders,  approvals  and  other
similar  documents  and  authorizations,   and  applications  therefor,  of  all
Governmental Entities.

      "Person" means any individual,  sole  proprietorship,  partnership,  joint
venture, trust,  unincorporated association,  corporation,  entity or government
(whether   federal,   state,   county,   city  or   otherwise,   including   any
instrumentality, division, agency or department thereof).

      "Proprietary  Rights"  means  all  patents,  patent  applications,  patent
disclosures and inventions (whether or not patentable and whether or not reduced
to  practice);  all  trademarks,  service  marks,  trade dress,  trade names and
corporate  names;  all  registered  and  unregistered  statutory  and common law
copyrights;  all  registrations,  applications  and  renewals  for  any  of  the
foregoing;  all  trade  secrets,  confidential  information,   ideas,  formulae,
compositions,  know-how,  manufacturing and production processes and techniques,
research and development information, drawings, specifications,  designs, plans,
improvements,   proposals,   technical  and  computer  data,  documentation  and
software, financial, business and marketing plans, and franchisee,  customer and
supplier lists and related information and all other proprietary rights.

      "S  Private  Placement"  means the  issuance  and sale by Alamar of Alamar
Common  Stock at a price of $0.625 per share  pursuant to a Regulation S Private
Placement to foreign  investors  conducted by American Equities and Commonwealth
commencing on the date hereof.

      "SEC" means the United States Securities and Exchange Commission.

      "Securities Act" means the Securities Act of 1933, as amended.

      "Tax"  means  any  and  all  federal,  state,  local  and  foreign  taxes,
assessments and other governmental charges, duties,  impositions and liabilities
relating to taxes,  including  taxes  based upon or  measured by gross  receipts
income,  profits,  sales,  use and  occupation,  and value  added,  ad  valorem,
transfer,  franchise,  withholding,  payroll, recapture,  employment, excise and
property taxes, together with all interest, penalties and additions imposed with
respect to such amounts and any obligations under any agreements or arrangements
with any other person with respect to such amounts and  including  any liability
for taxes of a predecessor entity.

                                     -50-

<PAGE>




      "Tax Returns" means  returns,  declarations,  reports,  claims for refund,
information  returns or other  documents  (including  any related or  supporting
schedules,  statements  or  information)  filed  or  required  to  be  filed  in
connection with the determination,  assessment or collection of any Taxes of any
party  or  the  administration  of  any  laws,   regulations  or  administrative
requirements relating to any Taxes.

      "Transaction Documents" means this Agreement, the Agreement of Merger, the
Voting  Trust  Agreement,  the  Employment  Agreements  and any  and  all  other
agreements,  documents  and  instruments  contemplated  by and  being  delivered
pursuant to or in connection with this Agreement.


                                  ARTICLE XI
                              GENERAL PROVISIONS

      11.1 Non-Survival of Representations  and Warranties.  The representations
and warranties of AccuMed and Alamar contained in this Agreement shall terminate
at the Effective  Time,  and only the covenants  that by their terms survive the
Effective Time shall survive the Effective Time.

      11.2 Notices. All notices and other  communications  hereunder shall be in
writing  and shall be deemed  given if  delivered  personally  or by  commercial
delivery  service,  or mailed by  registered or certified  mail (return  receipt
requested)  or sent via  telecopy  (receipt  confirmed)  to the  parties  at the
following  addresses or telecopy  numbers (or at such other  address or telecopy
numbers for a party as shall be specified by like notice):

            (a)   If to AccuMed, to:

                        AccuMed, Inc.
                        920 North Franklin, Suite 402
                        Chicago, Illinois  60610
                        Attention:  Peter P. Gombrich, President
                        Telecopy No.:  (312) 642-8684

                  with a copy to:

                        Katten Muchin & Zavis
                        525 West Monroe Street, Suite 1600
                        Chicago, Illinois  60661
                        Attention:  Russell N. Pallesen, Esq.
                                    Mark D. Wood, Esq.
                        Telecopy No.:  (312) 902-1061


                                     -51-

<PAGE>



            (b) If to Alamar, to:

                        Alamar Biosciences, Inc.
                        4110 North Freeway Boulevard
                        Sacramento, California  95834
                        Attention:  Chief Executive Officer
                        Telecopy No.:  (916) 567-3887

                  with a copy to:

                        Graham & James
                        400 Capital Mall, Suite 2400
                        Attention:  Gilles S. Attia, Esq.
                        Telecopy No.:  (916) 441-6700

      11.3  Interpretation.  When a  reference  is  made in  this  Agreement  to
Exhibits or Schedules, such reference shall be to an Exhibit or Schedule to this
Agreement  unless  otherwise  indicated.  The words  "include",  "includes"  and
"including"  when used herein shall be deemed in each case to be followed by the
words  "without  limitation".  The headings  contained in this Agreement are for
reference  purposes  only  and  shall  not  affect  in any  way the  meaning  or
interpretation of this Agreement. When reference is made herein to "the business
of" an entity  such  reference  shall be deemed to include  the  business of all
direct and indirect  subsidiaries of such entity.  Reference to the subsidiaries
of an entity shall be deemed to include all direct and indirect  subsidiaries of
such entity.

      11.4  Counterparts.  This  Agreement  may  be  executed  in  one  or  more
counterparts,  all of which shall be considered  one and the same  agreement and
shall become effective when one or more counterparts have been signed by each of
the parties and  delivered to the other  party,  it being  understood  that both
parties need not sign the same counterpart.

      11.5 Entire  Agreement.  This Agreement and the documents and  instruments
and other  agreements among the parties hereto as contemplated by or referred to
herein,  including the Exhibits and Schedules attached hereto (a) constitute the
entire agreement among the parties with respect to the subject matter hereof and
supersede all prior agreements and understandings,  both written and oral, among
the parties with respect to the subject  matter  hereof  including  that certain
letter of intent dated February 25, 1995 by and between  AccuMed and Alamar,  it
being understood that the Confidentiality Agreement shall continue in full force
and  effect  until  the  Closing  and  shall  survive  any  termination  of this
Agreement;  and (b) are not  intended to confer upon any other person any rights
or remedies hereunder, except as specifically set forth in Section 7.12.

      11.6  Severability.  In the event that any provision of this  Agreement or
the  application  thereof,  becomes  or is  declared  by a  court  of  competent
jurisdiction  to be  illegal,  void  or  unenforceable,  the  remainder  of this
Agreement  will  continue in full force and effect and the  application  of such
provision to other persons or circumstances will be interpreted so as reasonably
to effect the intent of the parties hereto. The parties further agree to replace
such  void or  unenforceable  provision  of  this  Agreement  with a  valid  and
enforceable provision that

                                     -52-

<PAGE>



will achieve, to the extent possible, the economic,  business and other purposes
of such void or unenforceable provision.

      11.7 Other  Remedies.  Except as otherwise  provided  herein,  any and all
remedies herein expressly  conferred upon a party will be deemed cumulative with
and not exclusive of any other remedy conferred hereby, or by law or equity upon
such party,  and the exercise by a party of any one remedy will not preclude the
exercise of any other remedy.

      11.8 Governing  Law. This Agreement  shall be governed by and construed in
accordance  with the laws of the State of Illinois,  regardless of the laws that
might otherwise govern under applicable principles of conflicts of law thereof.

      11.9 Rules of  Construction.  The parties hereto agree that they have been
represented  by counsel during the  negotiation  and execution of this Agreement
and, therefore, waive the application of any law, regulation, holding or rule of
construction  providing that  ambiguities in an agreement or other document will
be construed against the party drafting such agreement or document.

      11.10 Assignment.  No party may assign either this Agreement or any of its
rights, interests or obligations hereunder without the prior written approval of
the other party.





                                     -53-

<PAGE>



      IN WITNESS WHEREOF, Alamar and AccuMed have caused this Agreement to be
signed by themselves or their duly authorized respective officers, all as of the
date first written above.

                                   ALAMAR BIOSCIENCES, INC.


                                   By:   /s/ Kenneth E. Miller
                                       ---------------------------------------
                                         Kenneth E. Miller
                                         Chairman and Chief Executive Officer


                                   ACCUMED, INC.


                                   By:   /s/ Peter P. Gombrich
                                       ---------------------------------------
                                         Peter P. Gombrich
                                         Chairman, President and Chief Executive
                                         Officer


                                     -54-

<PAGE>



      In consideration  of the benefits the undersigned,  Peter P. Gombrich will
receive as the majority  shareholder,  President,  Chief  Executive  Officer and
Chairman of AccuMed, Inc., an Illinois corporation ("AccuMed"),  the undersigned
agrees  to be  bound  by the  terms of  Sections  6.2 and  7.17 of that  certain
Agreement and Plan of  Reorganization  dated as of April 21, 1995 by and between
Alamar Biosciences, Inc, a California corporation, and AccuMed.




                                    Peter P. Gombrich





                                     -55-

<PAGE>


                               LIST OF EXHIBITS


Exhibit A               Agreement of Merger
Exhibit B               AccuMed Affiliate Agreement





                                     -56-


                                 AMENDMENT NO. 1
                                       TO
                      AGREEMENT AND PLAN OF REORGANIZATION

     Amendment  No. 1 dated as of  August  1,  1995  (this  "Amendment")  to the
Agreement  and Plan of  Reorganization  dated as of April 21, 1995 (the  "Merger
Agreement")   between  Alamar  Biosciences,   Inc.,  a  California   corporation
("Alamar"), and AccuMed, Inc., an Illinois corporation doing business as AccuMed
International, Inc. ("AccuMed").

     NOW,  THEREFORE,  in consideration of the mutual covenants and promises set
forth  herein  and for other  good and  valuable  consideration,  the  adequacy,
sufficiency  and receipt of which are hereby  acknowledged,  and intending to be
legally  bound,  in  accordance  with Section 9.4 of the Merger  Agreement,  the
parties agree as follows:

     1. Section 1.6 of the Merger  Agreement is hereby deleted and the following
is inserted in lieu thereof:

     "1.6 Effect on Capital Stock and Warrants. At the Effective Time, by virtue
     of the Merger and  without any action on the part of AccuMed or the holders
     of any of the following securities:

          (a)  Conversion of AccuMed  Capital Stock and Warrants.  Each share of
     Common Stock,  no par value,  of AccuMed (the "AccuMed  Capital Stock") and
     each  Warrant to purchase a share of AccuMed  Capital  Stock (the  "AccuMed
     Warrants")  issued and outstanding  immediately prior to the Effective Time
     will be cancelled and extinguished and will be converted automatically into
     the right to receive, in the case of AccuMed Capital Stock, or the right to
     purchase,  in the case of AccuMed  Warrants,  the former  holder's pro rata
     portion of 5,750,000  shares of Common Stock,  no par value, of Alamar (the
     "Alamar  Common  Stock").  Each share of  AccuMed  Capital  Stock  shall be
     cancelled and converted as set forth in this Section  1.6(a) upon surrender
     of the certificate  representing such share of AccuMed Capital Stock in the
     manner  provided  in  Section  1.7 (or in the  case of a  lost,  stolen  or
     destroyed  certificate,  upon  delivery  of  an  affidavit  (and  bond,  if
     required) in the manner provide in Section 1.9). Each AccuMed Warrant shall
     be cancelled and converted into a warrant to purchase the holder's pro rata
     portion of the Alamar  Common  Stock (an "Alamar  Warrant") as set forth in
     Section 1.13 upon surrender of the warrant  certificate  representing  such
     AccuMed Warrant.

                                       -1-


<PAGE>


          (b)  Adjustments  to  exchange  Ratio.  The number of shares of Alamar
     Common Stock and Alamar  Warrants  into which each share of AccuMed  Common
     Stock and each AccuMed  Warrant,  respectively,  shall convert  pursuant to
     this Article I shall be adjusted to reflect  fully the effect of any split,
     reverse stock split, stock dividend (including any dividend or distribution
     of  securities  convertible  into  Alamar  Common  Stock),  reorganization,
     recapitalization  or other like change with respect to Alamar  Common Stock
     or AccuMed  Capital Stock  occurring after the date hereof and prior to the
     Effective  Time,  except for the  issuance  of any shares of Alamar  Common
     Stock pursuant to the S Private Placement and/or the D private Placement.

          (c) Fractional  Shares.  No fraction of a share of Alamar Common Stock
     will be issued  by  virtue of the  Merger;  in lieu  thereof  each  AccuMed
     Shareholder  who would  otherwise  be  entitled  receive to a fraction of a
     share of Alamar Common Stock (after  aggregating  all fractional  shares of
     Alamar  Common  Stock to be  received  by such  holder)  shall  receive one
     additional  share of Alamar  Common  Stock if such  fraction is one-half or
     more and no  additional  share of Alamar  Common Stock if such  fraction is
     less than  one-half.  Likewise,  Alamar  Warrants  will be  issued  for the
     purchase of whole shares only and not for any fraction of a share of Alamar
     Common  Stock;  each holder of an AccuMed  Warrant who would  otherwise  be
     entitled to receive an Alamar  Warrant for the  purchase of a fraction of a
     share of Alamar Common Stock (after  aggregating  all fractional  shares of
     Alamar  Common Stock such holder would be entitled to purchase  pursuant to
     the Alamar  Warrants to be received by such holder) shall receive a Warrant
     to purchase one additional share of Alamar Common Stock if such fraction is
     one-half or more and no  additional  share of Alamar  Common  Stock if such
     fraction is less than one-half.

     2. A new Section  1.13 is hereby added to the Merger  Agreement  to read in
its entirety as follows:

     1.13 Exchanqe of AccuMed Warrants.

                                      -2-
                                                                                



<PAGE>


          (a) Alamar to Provide  Alamar  Warrants.  Promptly after the Effective
     Time, Alamar shall make available to each former AccuMed Warrant holder for
     exchange  in  accordance  with this  Article  I,  through  such  reasonable
     procedures as Alamar may adopt,  the Alamar Warrants  issuable  pursuant to
     Section 1.6 in exchange for outstanding AccuMed Warrants.

          (b) Exchange  Procedures.  Promptly after the Effective  Time,  Alamar
     shall cause to be mailed to each holder of record of a warrant  certificate
     (a "Warrant  Certificate")  which  immediately  prior to the Effective Time
     represented  outstanding  AccuMed Warrants which were converted into Alamar
     Warrants  pursuant  to Section  1.6(a) (i) a letter of  transmittal  (which
     shall specify that delivery  shall be effected,  and risk of loss and title
     to the Warrant  Certificates  shall pass, only upon delivery of the Warrant
     Certificates  to Alamar and shall be in such form and have such  provisions
     as  Alamar  may  reasonably  specify)  and  (ii)  instructions  for  use in
     effecting  the  surrender  of a  Warrant  Certificate  in  exchange  for  a
     certificate  representing  an Alamar  Warrant.  Upon surrender of a Warrant
     Certificate  for  cancellation  to  Alamar  together  with  such  letter of
     transmittal,  duly  completed and validly  executed in accordance  with the
     instructions  thereto,  the former holder of such Warrant Certificate shall
     be entitled to receive in exchange therefor a certificate  representing the
     Alamar  Warrants  which such  holder has the right to receive  pursuant  to
     Section 1.6(a).

          (c) Provisions of Alamar  Warrants.  Each Alamar  Warrant  certificate
     shall be of like  tenor to the  cancelled  AccuMed  Warrant  for  which the
     Alamar  Warrant is  exchanged,  except as provided in this Section 1.13 and
     shall  specify (i) the number of shares of Alamar  Common Stock  underlying
     the Alamar  Warrant  determined  in  accordance  with Section 1.6 which the
     holder is or may become  entitled to purchase (in accordance  with Sections
     1.13(d),  (e) and (f) ), (ii) the  purchase  price or prices  per each such
     share (which  shall be based on the  purchase  price or prices set forth in
     the exchanged AccuMed

                                       -3-


<PAGE>


     Warrant and adjusted as  appropriate to correspond to the adjustment in the
     number of shares of Alamar  Common Stock  underlying  the Alamar  Warrant),
     (iii) that 65.2% of such shares are "Vested  Alamar Warrant  Shares",  (iv)
     17.4% of such shares are "First Year  Performance  Warrant  Shares" and (v)
     17.45% of such shares are "Second Year Performance Warrant Shares".

          (d)  Vested  Alamar  Warrant  Shares.  Each  Alamar  Warrant  shall be
     immediately exercisable with respect to the Vested Alamar Warrant Shares.

          (e)  First  Year   Performance   Warrant  Shares.   If  the  Surviving
     Corporation  achieves  the First Year  Performance  Targets  (as defined in
     Section  3.1),  the right to purchase  the First Year  Performance  Warrant
     Shares shall become vested on the date on which the  Surviving  Corporation
     shall have  determined  that the First Year  Performance  Targets have been
     achieved,  in  accordance  with  Section  3.4 such date shall be as soon as
     practicable after the end of the First Year Performance  Period (as defined
     in Section 3.1).

          (e)  Second  Year  Performance   Warrant  Shares.   If  the  Surviving
     Corporation  achieves  the Second Year  Performance  Targets (as defined in
     Section  3.2),  the right to purchase the Second Year  Performance  Warrant
     Shares shall become vested on the date on which the  Surviving  Corporation
     shall have  determined  that the First Year  Performance  Targets have been
     achieved,  in  accordance  with  Section  3.4 such date shall be as soon as
     practicable after the end of the Second Year Performance Period (as defined
     in Section 3.2).

          (f)  Earn-Back  Provisions.  If the  Surviving  Corporation  fails  to
     achieve the First Year  Performance  Targets but does achieve the Earn-Back
     Targets (as defined in Section 3.3) for the Second Year Performance Period,
     the right to  purchase  the First Year  Performance  Warrant  Shares  shall
     become  vested on the date on which the  Surviving  Corporation  shall have
     determined that the

                                       -4-



<PAGE>


     Earn-Back  Targets  have  been  achieved,  such  date  shall  be as soon as
     practicable following the end of the Second Year Performance Period.

          (g) Failure to Achieve Performance Targets,  Earn-Back Targets. If the
     Surviving  Corporation fails to achieve the First Year Performance  Targets
     and the Earn-Back Targets, the right to purchase the First Year Performance
     Warrant Shares shall at no time become vested. If the Surviving Corporation
     fails to achieve the Second Year Performance Targets, the right to purchase
     the Second Year Performance  Warrant Shares shall at no time become vested.
     If the Surviving  Corporation shall determine that the right to acquire the
     First Year  Performance  Warrant Shares and/or the Second Year  Performance
     Warrant  Shares shall at no time become vested,  the Surviving  Corporation
     may, in its discretion,  issue a new warrant in exchange for an outstanding
     Alamar  Warrant;  any such new warrant shall be of like tenor but shall not
     include  such First Year  Performance  Warrant  Shares  and/or  Second Year
     Performance Warrant Shares, as the case may be.

     3.  Section  7.17(c)  of the Merger  Agreement  is hereby  deleted  and the
following is inserted in lieu thereof:

          (c)  During the  Interim  Period,  the  Interim  Board  shall take all
     actions  necessary  to create an "Expenses  Committee".  During the Interim
     Period the  Expenses  Committee  shall  consist of Jack  Halperin,  Richard
     Corbin and Leonard Schiller. From and after the Effective Time the Expenses
     Committee  shall  consist  of three  directors  appointed  by the  Board of
     Directors of the Surviving  Corporation.  During (i) the Interim Period and
     (ii) from and following the Effective  Time until such time, if any, as the
     Expenses  Committee is dissolved by the Board of Directors of the Surviving
     Corporation,  the  Expenses  Committee  shall  approve  all  the  following
     expenditures  by Alamar or the Surviving  Corporation,  as the case may be,
     (x) any  expenditure  of $25,000 or more and (y)  capital  expenditures  of
     $5,000 or more  ("capital  expenditures"  for the  purposes of this Section
     7.17(c), shall mean any

                                       -5-



<PAGE>


     expenditure  which is required by GAAP to be capitalized  and which appears
     on Alamar's balance sheet in the category of property, plant or equipment).

     IN WITNESS  WHEREOF,  the parties  have caused  this  Amendment  to be duly
executed as of the date first above written.

                                             ALAMAR BIOSCIENCES, INC.

                                             By: /s/PETER P. GOMBRICH
                                                 ------------------------
                                                 Peter P. Gombrich
                                                 Acting Chief Executive Officer

                                             ACCUMED, INC.

                                             By: /s/PETER P. GOMBRICH
                                                 ------------------------
                                                 Peter P. Gombrich
                                                 Chief Executive Officer

                                       -6-



                                 AMENDMENT NO. 2
                                       TO
                      AGREEMENT AND PLAN OF REORGANlZATION

     Amendment No. 2, dated as of October 6, 1995 (this "Amendment") to the
Agreement and Plan of Reorganization dated as of April 21, 1995, (the "Merger
Agreement") as amended by Amendment No 1, dated August 1, 1995, between Alamar
Biosciences, Inc., a California corporation ("Alamar"), and AccuMed, Inc., an
Illinois corporation doing business as AccuMed International, Inc. ("AccuMed").

     NOW, THEREFORE, in consideration of the mutual covenants and promises set
forth herein and for other good and valuable consideration, the adequacy,
sufficiency and receipt of which are hereby acknowledged, and intending to be
legally bound, in accordance with Section 9.4 of the Merger Agreement, the
parties agree as follows:

     1. Section 1.6 of the Merger Agreement is hereby deleted and the following
is inserted in lieu thereof:

          "1.6 Effect on Capital Stock and Warrants. At the Effective Time, by
          virtue of the Merger and without any action on the part of AccuMed or
          the holders of any of the following securities:

               (a) Conversion of AccuMed Capital Stock and Warrants. Each share
               of Common Stock, no par value, of AccuMed (the "Accumed Capital
               Stock") and each Warrant to purchase a share of AccuMed Capital
               Stock (the "AccuMed Warrants") issued and outstanding immediately
               prior to the Effective Time will be canceled and extinguished and
               will be converted automatically into the right to receive, in the
               case of AccuMed Capital Stock, or the right to purchase, in the
               case of AccuMed Warrants, the former holder's pro rata portion of
               6,178,104 shares of Common Stock, no par value, of Alamar (the
               "Alamar Common Stock"). Each share of AccuMed Capital Stock shall
               be canceled and converted as set forth in this Section 1.6 (a)
               upon surrender of the certificate representing such share of
               AccuMed Capital Stock in the manner provided in Section 1.7 (or
               in the case of a lost, stolen or destroyed certificate, upon
               delivery of an affidavit (and bond, if required) in manner
               provided in Section 1.9). Each AccuMed Warrant shall be canceled
               and converted into a warrant to purchase the holder's pro rata
               portion of the Alamar Common Stock (an "Alamar Warrant") as set
               forth in Section 1.13 upon surrender of the warrant certificate
               representing such AccuMed Warrant.

<PAGE>

               (b) Adjustments to Exchange Ratio. The number of shares of Alamar
               Common Stock and Alamar Warrants into which each share of AccuMed
               Common Stock and each AccuMed Warrant, respectively, shall
               convert pursuant to this Article I shall be adjusted to reflect
               fully the effect of any split, reverse stock split, stock
               dividend (including any dividend or distribution of securities
               convertible into Alamar Common Stock), reorganization,
               recapitalization or other like change with respect to Alamar
               Common Stock or Accumed Capital Stock occurring after the date
               hereof and prior to the Effective Time, except for the issuance
               of any shares of Alamar Common Stock pursuant to the S Private
               Placement and/or the D Private Placement

               (c) Fractional Shares. No fraction of a share of Alamar Common
               Stock will be issued by virtue of the Merger; in lieu thereof
               each AccuMed Shareholder who would otherwise be entitled receive
               to a fraction of a share of Alamar Common Stock (after
               aggregating all fractional shares of Alamar Common Stock to be
               received by such holder) shall receive one additional share of
               Alamar Common Stock if such fraction is one-half or more and no
               additional share of Alamar Common Stock if such fraction is less
               than one-half. Likewise, Alamar Warrants will be issued for the
               purchase of whole shares only and not for any fraction of a share
               of Alamar Common Stock; each holder of an AccuMed Warrant who
               would otherwise be entitled to receive an Alamar Warrant for the
               purchase of a fraction of a share of Alamar Common Stock (after
               aggregating all fractional shares of Alamar Common Stock such
               holder would be entitled to purchase pursuant to the Alamar
               Warrants to be received by such holder) shall receive a Warrant
               to purchase one additional share of Alamar Common Stock if such
               fraction is one-half or more and no additional share of Alamar
               Common Stock if such fraction is less than one-half.

     2. Section 2.1 of the Merger Agreement is hereby deleted and the following
is inserted in lieu thereof:

<PAGE>

     2.1 Grant of Option. In further consideration of AccuMed's execution of
     this Agreement and consummation of the Merger and the operation of
     AccuMed's business by its management and employees during the period from
     the date hereof until the Closing Time for the ultimate benefit of Alamar,
     Alamar shall, on the Closing Date, grant to AccuMed's officers and
     employees, options (the "Options") to purchase from Alamar up to an
     additional 1,000,000 shares of Alamar Common Stock plus, if the Option
     Price (as defined below) is greater than $1.25, such number of shares of
     Alamar Common Stock as shall be determined by subtracting $1.25 from the
     Option Price, then multiplying by up to 1,000,000 and dividing by the
     Option Price (collectively, the "Option Shares"). The Options shall be
     granted pursuant to the Stock Option Plan of Alamar in effect as of the
     Closing Date (the "Option Plan"). The Option Shares shall be distributed on
     the Closing Date, as determined by the Board of Directors of AccuMed prior
     to the Closing Date, subject to applicable law and the terms of the Option
     Plan. Alamar covenants that, at all times from the date hereof until the
     earlier of the expiration of the Option Period (as hereinafter defined) or
     the exercise in full of all of the Options, Alamar will have reserved for
     issuance under the Option Plan such number of authorized but not issued and
     not outstanding shares of Alamar Common Stock as equals (a) the aggregate
     number of Option Shares issuable upon exercise of Options, less (b) such
     number of shares of Alamar Common Stock as have previously been issued upon
     exercise of Options. The Option Plan shall be amended, if necessary, so
     that a sufficient number of shares of Alamar Common Stock are reserved for
     issuance upon exercise of Options, and any such amendment shall be
     submitted to Alamar's shareholders for approval at the Alamar Shareholders'
     Meeting.

     IN WITNESS WHEREOF, the parties have caused this Amendment to be duly
executed as of the date first above written.


                                        ALAMAR BIOSCIENCES, INC.


                                        By:  /s/  Peter P. Gombrich
                                             -------------------------------
                                             Peter P. Gombrich
                                             Acting Chief Executive Officer


                                        ACCUMED, INC.
          

                                        By:  /s/  Peter P. Gombrich
                                             -------------------------------
                                             Peter P. Gombrich
                                             Chief Executive Officer



                              AGREEMENT OF MERGER

     This Agreement of Merger ("Agreement") is entered into between Alamar
Biosciences, Inc., a California corporation (herein "Surviving Corporation"),
and AccuMed, Inc., an Illinois corporation (herein "Merging Corporation").

1.   Merging Corporation shall be merged into Surviving Corporation.

2.   Each issued and outstanding share of Merging Corporation shall be converted
     into 2.4318999 shares of Common Stock, no par value, of Surviving
     Corporation and each outstanding Warrant to purchase Common Stock shall be
     converted into a Warrant to purchase 2.4318999 shares of Common Stock, no
     par value, of Surviving Corporation; provided, however, that no fractional
     shares shall be issued, but in lieu thereof each Merging Corporation
     shareholder who would otherwise be entitled to a fraction of a share of
     Surviving Corporation (after aggregating all fractional shares of Surviving
     Corporation to be received by such shareholder) shall receive from
     Surviving Corporation one additional share of Surviving Corporation in the
     event such fraction is one-half or more and no additional shares of
     Surviving corporation in the event such fraction is less than one-half;
     provided, however, that if the fraction which any shareholder would
     otherwise be entitled receive is more than one-half of 1 percent of the
     total shares such person is entitled to receive, such person shall receive
     one additional full share.

3.   The outstanding shares of Surviving Corporation shall remain outstanding
     and are not effected by the Merger.

4.   Merging Corporation shall from time to time, as and when requested by
     Surviving Corporation, execute and deliver all such documents and
     instruments and take all such actions necessary or desirable to evidence or
     carry out this merger.

5.   The effect of the merger and the effective date of the merger are as
     prescribed by law.

6.   Merging Corporation and Surviving Corporation have also entered into that
     certain Agreement and Plan of Reorganization, dated as of April 21, 1995,
     as amended by Amendment No. 1 dated as of August 1, 1995 and Amendment No.
     2 dated as of October 6, 1995 (the "Plan of Reorganization"); the Plan of
     Reorganization and this Agreement are intended to be construed together and
     the terms of the Plan of Reorganization are incorporated herein by this
     reference.

                                                        ENDORSED
                                                         FILED
                                        In the office of the Secretary of State
                                               of the State of California
                    
                                                      DEC 29 1995
                    
                                             BILL JONES, Secretary of State

<PAGE>

IN WITNESS WHEREOF the parties have examined this Agreement.


                                        ALAMAR BIOSCIENCES, INC.


                                        By:  /s/  Mark L. Santor
                                             ---------------------------
                                             Mark L. Santor, Vice President,
                                             Finance and Secretary


                                                      -AND-


                                        ACCUMED, INC.

                                        By:  /s/  Peter P. Gombrich
                                             ---------------------------
                                             Peter P. Gombrich, President


                                        By:  /s/  Peter P. Gombrich
                                             ---------------------------
                                             Peter P. Gombrich, Secretary

<PAGE>

                            CERTIFICATE OF APPROVAL
                                       OF
                              AGREEMENT OF MERGER


Mark L. Santor certifies that:

1.   He is the vice president, finance and secretary, of Alamar Biosciences,
     Inc., a California corporation ("Alamar").

2.   The Agreement of Merger in the form attached hereto was duly approved by
     the Board of Directors and shareholders of Alamar.

3.   The principal terms of the Agreement of Merger were adopted by the
     affirmative vote of the outstanding shares of Alamar which equaled or
     exceeded the required vote; which such vote was a majority of the
     outstanding shares.

4.   There is only one class of shares outstanding and the number of shares
     outstanding is 11,115,339.

I further declare under penalty of perjury under the laws of the State of
California that the matters set forth in this certificate are true and correct
of my own knowledge.

Dated: December 28, 1995


                                        /s/  Mark L. Santor
                                        -----------------------------
                                        Mark L. Santor, Vice President, Finance


                                        /s/  Mark L. Santor
                                        -----------------------------
                                        Mark L. Santor, Secretary

<PAGE>

                            CERTIFICATE OF APPROVAL
                                       OF
                              AGREEMENT OF MERGER


Peter P. Gombrich certifies that:

1.   He is the President and Secretary of AccuMed Inc., an Illinois corporation
     ("AccuMed").

2.   The Agreement of Merger in the form attached hereto was duly approved by
     the Board of Directors and shareholders of AccuMed.

3.   The principal terms of the Agreement of Merger were adopted by the
     affirmative vote of the outstanding shares of AccuMed which equaled or
     exceeded the required vote; which such vote was two-thirds of the total
     outstanding shares.

4.   There is only one class of shares outstanding and the number of shares
     outstanding is 2,390,441.

I further declare under penalty of perjury under the laws of the State of
California that the matters set forth in this certificate are true and correct
of my own knowledge.

Dated: December 28, 1995


                                        /s/  Peter P. Gombrich
                                        -----------------------------
                                        Peter P. Gombrich, President


                                        /s/  Peter P. Gombrich
                                        -----------------------------
                                        Peter P. Gombrich, Secretary

<PAGE>

                              State of California

                                     [SEAL]

                               SECRETARY OF STATE

                              CORPORATION DIVISION


     I,  BILL  JONES,  Secretary  of State of the  State of  California,  hereby
certify:

     That the annexed  transcript has been compared with the corporate record on
file in this office,  of which it purports to be a copy,  and that same is full,
true and correct.

                                                IN WITNESS WHEREOF,   I  execute
                                                  this certificate and affix the
                                                  Great  Seal  of the  State  of
                                                  California this

                                                            JAN 10 1996



[THE STATE OF CALIFORNIA SEAL]


                                                  /s/  Bill Jones
                                                  ---------------------
                                                  Secretary of State



                                 ACCUMED, INC.

                               AFFILIATE AGREEMENT

     This AFFILIATE  AGREEMENT (this "Agreement") is made and entered into as of
April 21, 1995 by and among ACCUMED, INC., an Illinois corporation  ("Company"),
ALAMAR  BIOSCIENCES,   INC.,  a  California  corporation  ("Alamar"),   and  the
undersigned affiliate ("Affiliate") of the Company.

                                 R E C I T A L S

     A. The  Company  and Alamar  have  entered  into an  Agreement  and Plan of
Reorganization, dated April 21, 1995 (the "Reorganization Agreement"), providing
for the merger  ("Merger") of the Company with and into the Alamar.  Pursuant to
the Merger,  among other things,  the outstanding  shares of Common Stock of the
Company  will be  converted  into  shares of Common  Stock of Alamar at the rate
determined in accordance with the Reorganization Agreement.

     B.  Affiliate is the  beneficial  owner (as defined in Rule 13d-3 under the
Securities Exchange Act of 1934, as amended (the "Exchange Act")) of such number
of shares of the  outstanding  Common  Stock,  no par  value per  share,  of the
Company as is indicated on the final page of this Agreement (the "Shares").

     C. Affiliate  understands that Affiliate may be deemed to be an "affiliate"
of the Company (within the meaning of Rule 145 promulgated  under the Securities
Act of 1933, as amended (the "Securities Act")), the Shares may only be disposed
of in  conformity  with the  limitations  described  herein.  Affiliate has been
informed  that the  treatment of the Merger as a tax-free  reorganization  under
applicable  provisions  of the  Internal  Revenue Code of 1986,  as amended,  is
dependent upon the accuracy of certain of the representations and warranties and
the  compliance  with  certain of the  agreements  set forth  herein.  Affiliate
further  understands  that the  representations,  warranties  and agreements set
forth  herein  will be relied upon by Alamar,  the Company and their  respective
counsel and accounting firms.

     NOW, THEREFORE, the parties agree as follows:

     1. Tax Treatment;  Rule 145.  Affiliate  understands  and agrees that it is
intended  that the  Merger  will be treated as a  "reorganization"  for  federal
income tax purposes. Affiliate further understands and agrees that Affiliate may
be deemed to be an  "affiliate"  of the  Company  within the meaning of Rule 145
under the Securities Act,  although nothing contained herein should be construed
as an admission of such fact.

     2. Reliance Upon  Representations  Warranties and Covenants.  Affiliate has
been informed that the treatment of the Merger as a  reorganization  for federal
income tax purposes requires that a sufficient number of former  shareholders of
the Company maintain a meaningful


<PAGE>


continuing  equity  ownership  interest in Alamar  after the  Merger.  Affiliate
understands that the representations,  warranties and covenants of Affiliate set
forth  herein  will be relied upon by Alamar,  the Company and their  respective
counsel and accounting firms.

     3.  Representations  Warranties  and  Covenants  of  Affiliate.   Affiliate
represents, warrants and covenants as follows:

          (a) Affiliate has full power and authority to execute this  Agreement,
     to make the representations,  warranties and covenants herein contained and
     to perform Affiliate's obligations hereunder.

          (b) Set forth  below the  signature  below is the  number of shares of
     Common Stock of the Company ("Company Stock") owned by Affiliate, including
     all  Company  Stock as to which  Affiliate  has sole or  shared  voting  or
     investment  power and all rights,  options and warrants to acquire  Company
     Stock owned or held by Affiliate.

          (c) Affiliate will not sell, transfer,  exchange,  pledge or otherwise
     dispose of, or make any offer or agreement relating to any of the foregoing
     with respect to, any shares of Common Stock of Alamar ("Alamar Stock") that
     Affiliate may acquire in connection with the Merger, or any securities that
     may be paid as a dividend or otherwise  distributed thereon or with respect
     thereto or issued or delivered in exchange or  substitution  therefor  (all
     such  shares  and other  securities  of Alamar are  sometimes  collectively
     referred to as  "Restricted  Securities"),  or any  option,  right or other
     interest  with  respect  to any  Restricted  Securities,  unless:  (i) such
     transaction  is  permitted  pursuant  to Rule  145(c) and 145(d)  under the
     Securities  Act;  (ii) counsel  representing  Affiliate,  which  counsel is
     reasonably  satisfactory to Alamar,  shall have advised Alamar in a written
     opinion letter satisfactory to Alamar and Alamar's legal counsel,  and upon
     which Alamar and its legal counsel may rely, that no registration under the
     Securities  Act would be required in  connection  with the  proposed  sale,
     transfer or other  disposition;  (iii) a registration  statement  under the
     Securities Act covering the Alamar Stock  proposed to be sold,  transferred
     or otherwise  disposed of,  describing the manner and terms of the proposed
     sale,  transfer or other disposition,  and containing a current prospectus,
     shall have been filed with the  Securities  and  Exchange  Commission  (the
     "SEC") and made effective  under the Securities  Act; or (iv) an authorized
     representative  of the SEC shall have rendered  written advice to Affiliate
     (sought by Affiliate or counsel to  Affiliate,  with a copy thereof and all
     other  related  communications  delivered to Alamar) to the effect that the
     SEC would take no action,  or that the staff of the SEC would not recommend
     that the SEC take any action,  with respect to the proposed  disposition if
     consummated.

          (d) Affiliate  has, and as of the Effective Time will have, no present
     plan or  intention  (a  "Plan")  to sell,  transfer,  exchange,  pledge  or
     otherwise  dispose of,  including a  distribution  by a partnership  to its
     partners,  or a corporation to its  shareholders,  or any other transaction
     which  results  in a  reduction  in  the  risk  of  ownership  (any  of the
     foregoing,  a "Sale") of the  shares of Alamar  Stock  that  Affiliate  may
     acquire in connection  with the Merger,  or any securities that may be paid
     as a dividend or otherwise  distributed  thereon  with  respect  thereto or
     issued or delivered in exchange or substitution therefor.  Affiliate is not
     aware of, or participating in, any Plan on the part


                                       -2-


<PAGE>


of the Company's  shareholders  to engage in Sales of the shares of Alamar Stock
to be  issued  in the  Merger.  If any of  Affiliate's  representations  in this
Section 4(d) cease to be true at any time prior to the Effective Time, Affiliate
will deliver to each of the Company and Alamar,  prior to the Effective  Time, a
written statement to that effect, signed by Affiliate.

     4. Rules 144 and 145. From and after the Effective  Time and for so long as
is  necessary  in order to permit  Affiliate  to sell the  Alamar  Stock held by
Affiliate  pursuant  to Rule 145 under the  Securities  Act and,  to the  extent
applicable,  Rule 144 under the Securities  Act,  Alamar will use its reasonable
efforts  to file on a  timely  basis  all  reports  required  to be  filed by it
pursuant to Section 13 of the Exchange Act,  referred to in paragraph  (c)(1) of
Rule 144 under the  Securities  Act,  in order to permit  Affiliate  to sell the
Alamar Stock held by it pursuant to the terms and  conditions  of Rule 145 under
the  Securities  Act  and  the  applicable  provisions  of Rule  144  under  the
Securities Act.

     5.  Limited  Resales.  Affiliate  understands  that,  in  addition  to  the
restrictions  imposed under Section 3 of this Agreement,  the provisions of Rule
145 under the  Securities  Act limit  Affiliate's  public  resales of Restricted
Securities, in the manner set forth in subsections (a), (b) and (c) below:

          (a)  Unless and until the  restriction  "Cut-off"  provisions  of Rule
     145(d)(2) or Rule 145(d)(3) under the Securities Act set forth below become
     available,  public  resales of  Restricted  Securities  may only be made by
     Affiliate in compliance  with the  requirements of Rule 145(d)(1) under the
     Securities  Act.  Rule  145(d)(1)  under the  Securities  Act permits  such
     resales only: (i) while Alamar meets the public information requirements of
     Rule 144(c) under the Securities  Act; (ii) in brokers'  transactions or in
     transactions  with a market maker;  and (iii) where the aggregate number of
     Restricted  Securities  sold  at  any  time  together  with  all  sales  of
     restricted  Alamar Stock sold for Affiliate's  account during the preceding
     three-month  period does not exceed the greater of (A) one percent  (1%) of
     the Alamar Stock outstanding or (B) the average weekly volume of trading in
     Alamar Stock on all national securities exchanges,  or reported through the
     automated quotation system of a registered securities  association,  during
     the four (4) calendar  weeks  preceding the date of receipt of the order to
     execute the sale.

          (b) Affiliate  may make  unrestricted  sales of Restricted  Securities
     pursuant to Rule  145(d)(2) of the  Securities  Act if: (i)  Affiliate  has
     beneficially  owned (within the meaning of Rule 144(d) under the Securities
     Act)  the  Restricted  Securities  for at least  two (2)  years  after  the
     Effective  Time;  (ii)  Affiliate is not an affiliate of Alamar;  and (iii)
     Alamar meets the public  information  requirements of Rule 144(c) under the
     Securities Act.

          (c) Affiliate  may make  unrestricted  sales of Restricted  Securities
     pursuant  to Rule  145(d)(3)  under the  Securities  Act if  Affiliate  has
     beneficially  owned (within the meaning of Rule 144(d) under the Securities
     Act) the Restricted Securities for at least three (3) years and is not, and
     has not been for the last three (3) months, an affiliate of Alamar.

                                      -3 -


<PAGE>


          (d) Parent  acknowledges  that the  provisions of Section 3(c) of this
     Agreement  will  be  satisfied  as to any  sale by the  undersigned  of the
     Restricted  Securities pursuant to Rule 145(d) under the Securities Act, by
     a broker's  letter and a letter from the  undersigned  with respect to that
     sale  stating  that  each  of  the  above-described  requirements  of  Rule
     145(d)(1)  under  the  Securities  Act has been met or is  inapplicable  by
     virtue of Rule 145(d)(2)  under the Securities Act or Rule 145(d)(3)  under
     the Securities Act; provided,  however, that Alamar has no reasonable basis
     to believe that such sales were not made in compliance with such provisions
     of Rule 145(d) under the Securities Act.

     6.  Legends.  Affiliate  also  understands  and agrees  that stop  transfer
instructions   will  be  given  to  Alamar's  transfer  agent  with  respect  to
certificates  evidencing the Restricted Securities and that there will be placed
on the  certificates  evidencing the Restricted  Securities  legends  stating in
substance:

               "THE SHARES  REPRESENTED BY THIS  CERTIFICATE  MAY
               NOT  BE   OFFERED,   SOLD,   PLEDGED,   EXCHANGED,
               TRANSFERRED  OR  OTHERWISE  DISPOSED  OF EXCEPT IN
               ACCORDANCE WITH THE REQUIREMENTS OF THE SECURITIES
               ACT OF 1933, AS AMENDED,  AND THE OTHER CONDITIONS
               SPECIFIED  IN  THAT  CERTAIN  AFFILIATE  AGREEMENT
               DATED AS OF APRIL  10,  1995 BY AND  AMONG  ALAMAR
               BIOSCIENCES,   INC.,   ACCUMED,   INC.   AND   THE
               SHAREHOLDER,  A COPY OF WHICH AFFILIATE  AGREEMENT
               MAY BE INSPECTED BY THE HOLDER OF THIS CERTIFICATE
               AT THE OFFICES OF ALAMAR BIOSCIENCES,  INC. ALAMAR
               BIOSCIENCES,  INC. WILL FURNISH, WITHOUT CHARGE, A
               COPY  THEREOF TO THE  HOLDER OF THIS  CERTIFICATE,
               UPON WRITTEN REQUEST THEREFOR.

Alamar agrees to remove promptly such stop transfer instructions and legend upon
full  compliance  with this  Agreement by the  undersigned,  including,  without
limitation,  a sale or transfer of Alamar  Stock  permitted  under  Section 3(c)
above.

     7.  Termination.  This  Agreement  shall be  terminated  and shall be of no
further force and effect upon the  termination of the  Reorganization  Agreement
pursuant to Article VII of the Reorganization Agreement.

     8.  Counterparts.   This  Agreement  shall  be  executed  in  one  or  more
counterparts,  each of  which  shall be  deemed  an  original,  and all of which
together shall constitute one instrument.

     9. Binding  Agreement.  This  Agreement will inure to the benefit of and be
binding  upon and  enforceable  against  the parties  and their  successors  and
assigns, including administrators,  executors, representatives,  heirs, legatees
and devisees of  Affiliate  and any pledgee  holding  Restricted  Securities  as
collateral.

                                       -4-

<PAGE>


     10. Waiver. No waiver by any party hereto of any condition or of any breach
of any  provision of this  Agreement  shall be  effective  unless in writing and
signed by each party hereto.

     11.  Governing  Law. This  Agreement  shall be governed by and  construed,
interpreted and enforced in accordance with the laws of the State of Illinois.

     12 Effect of Headiings.  The section  headings  herein are for  convenience
only and shall not affect the construction or interpretation of this Agreement.

     13. Third Party Reliance.  Counsel to and accountants for the parties shall
be entitled to rely upon this Agreement.

     IN WITNESS  WHEREOF,  the parties  have caused  this  Agreement  to be duly
executed on the day and year first above written.

ACCUMED, INC.,                             AFFILIATE:
an Illinois corporation




By: /s/ Peter P. Gombrich                  By:/s/ Peter P. Gombrich
   --------------------------                 -------------------------
Name:  Peter P. Gombrich                   Name:  Peter P. Gombrich
Title: President and Chief Executive       Title: Chairman, President and Chief
       Officer.                                   Executive Officer


ALAMAR BIOSCIENCES, INC.,                   Affiliate's Address for Notice:
a California corporation
                                            920 N. Franklin
                                            Suite 402
By: /s/ Kenneth E. Miller                   Chicago, Illinois 60610
    --------------------------              
Name:  Kenneth E. Miller
Title: Chairman and Chief Executive
       Officer
                                            Shares beneficially owned:
                                            1,347,000 shares of AccuMed, Inc.
                                            Common Stock
 
                                      -5-


                         WAIVER UNDER MERGER AGREEMENT

     Reference is made to the Agreement and Plan of Reorganization  (the "Merger
Agreement")  dated as of April 21, 1995,  as amended by Amendment No. 1 dated as
of August 1, 1995 and Amendment No. 2 dated as of October 6, 1995 between Alamar
Biosciences,  Inc., a California corporation  ("Alamar"),  and AccuMed, Inc., an
Illinois  corporation  ("AccuMed").  All capitalized terms not otherwise defined
herein shall have the same meaning as when used in the merger Agreement.

     WHEREAS,  Section 7.18 of the Merger Agreement provides that the persons to
serve as directors of the Surviving Corporation will each serve a two-year term;
and

     WHEREAS,  both California  corporate law and Delaware corporate law require
that a meeting of  shareholders  be held  annually  for the  purpose of electing
directors;

     NOW  THEREFORE,  each of Alamar and AccuMed  hereby waives the  requirement
that the Surviving  Corporation  take action as is necessary to cause such board
members to serve a two-year term,  and mutually  consent to allow such directors
to serve the maximum term  permissible  under  applicable  corporate  law, which
shall  be  until  the next  annual  meeting  of  shareholders  of the  Surviving
Corporation, or until their earlier removal or resignation.

     IN WITNESS WHEREOF, the parties have caused this Waiver to be duly executed
as of November 20, 1995.


                                        ALAMAR BIOSCIENCES, INC.


                                        By:  /s/  Mark L. Santor
                                             ----------------------------
                                             Mark L. Santor, Chief
                                             Financial Officer



                                        ACCUMED, INC.


                                        By:  /s/  Peter P. Gombrich
                                             ----------------------------
                                             Peter P. Gombrich, Chief
                                             Executive Officer



              MUTUAL WAIVER PURSUANT TO SECTIONS 8.2(e) and 8.3(e)
                               OF MERGER AGREEMENT

     This  Mutual  Waiver  is  hereby  made as of  December  19,  1995 by Alamar
Biosciences,  Inc. ("Alamar"), and AccuMed, Inc. ("AccuMed").  Reference is made
to the Agreement and Plan of Reorganization dated as of April 21, 1995 by Alamar
and  AccuMed,  as amended  by  Amendment  No. 1 dated as of August 1, 1995,  and
Amendment No. 2 dated as of October 6, 1995 (the "Merger Agreement").  Terms not
otherwise defined herein shall have the same meanings as when used in the Merger
Agreement.

     1. Each of Alamar and AccuMed  hereby waives the  requirements  pursuant to
Section 8.2(e) and Section 8.3(e),  respectively,  that Employment Agreements be
executed between the Surviving  Corporation and Peter P. Gombrich,  Kenn Miller,
Mark L. Santor, Derek Kelly, Roger Grist, and Michael D. Burke.

     2. Each of the parties  hereby  consents  to and agrees that the  surviving
Corporation  shall  adopt and assume the  obligations  under the (i)  Employment
Agreement dated as of August 1, 1994, between Mr. Gombrich and AccuMed, (ii) the
Employment Letter dated March 2, 1995 between Accumed and Mr. Miller,  (iii) the
Employment  Letter dated February 28, 1995 between  Accumed and Mr. Santor,  and
(iv) the Employment  Agreement as in effect between AccuMed and Mr. Burke as of
the date hereof, and that the Service Agreement between Sensititre and Mr. Kelly
dated May 9, 1994 and the Service  Agreement between Dr. Grist and Sensititre as
in effect on the date hereof  shall  continue in full force and effect after the
Effective Time of the Merger.



                                        ALAMAR BIOSCIENCES, INC.
                                        a California corporation


                                        By:  /s/  Mark L. Santor
                                             ---------------------------
                                             Mark L. Santor
                                             Chief Financial Officer




                                        ACCUMED, INC.,
                                        a California corporation


                                        By:  /s/  Peter P. Gombrich
                                             ---------------------------
                                             Peter P. Gombrich
                                             Chief Executive Officer

     WARRANT AGREEMENT dated as of December 31, 1994 between Alamar BioSciences,
Inc., a California  corporation  (the "Company"),  and  Commonwealth  Associates
(hereinafter referred to as "Commonwealth").

                              W I T N E S S E T H:

     WHEREAS,   the  Company   proposes  to  issue  to   Commonwealth   warrants
("Warrants")  to purchase up to 420,000 shares (the "Shares") of common stock of
the Company, no par value (the "Common Stock"); and

     WHEREAS, the Warrants issued pursuant to this Agreement are being issued by
the Company to Commonwealth or its designees as reimbursement to Commonwealth of
certain  expenses  incurred  by  Commonwealth  in  connection  with  its role as
placement  agent for a proposed  private  placement of the Company's  securities
which was abandoned in November 1994 and the  cancellation of warrants issued by
the Company to  Commonwealth  in connection  with the Company's  initial  public
offering;

     NOW,  THEREFORE,   in  consideration  of  the  premises,   the  payment  by
Commonwealth  to the Company of ONE DOLLAR  ($1.00),  the agreements  herein set
forth and other good and valuable consideration,  the receipt and sufficiency of
which are hereby acknowledged, the parties hereto agree as follows:

     1. Grant.

     Commonwealth,  and/or  its  designees  who  are  officers  or  partners  of
Commonwealth,  are  hereby  granted  the  right to  purchase,  at any time  from
December  31, 1994 until 5:00 P.M.  New York City time on December 31, 1999 (the
"Warrant  Exercise  Term"),  up to 420,000 (subject to adjustment as provided in
Article 8 hereof) Shares at an initial  exercise price (subject to adjustment as
provided in Article 8 hereof) of $.25 per Share.

     2. Warrant Certificates.

     The warrant certificates (the "Warrant  Certificates")  delivered and to be
delivered  pursuant to this Agreement  shall be in the form set forth as Exhibit
A, attached  hereto and made a part hereof,  with such  appropriate  insertions,
omissions,  substitutions  and other variations as required or permitted by this
Agreement.

     3. Exercise of Warrants.

          3.1 Cash Exercise.  The Warrants  initially are exercisable at a price
of $.25 per Share,  payable in cash or by check to the order of the Company,  or
any combination of cash or check, subject to adjustment as provided in Article 8
hereof.  Upon  surrender  of the Warrant  Certificate  with the annexed  Form of
Election to Purchase duly executed,  together with payment of the Exercise Price
(as hereinafter  defined) for the Shares purchased,  at the Company's  principal
offices (presently located at 4110 N. Freeway Blvd.,  Sacramento,  CA 95834) the
registered  holder of a Warrant  Certificate  ("Holder" or  "Holders")  shall be
entitled to receive a certificate or  certificates  for the Shares so purchased.
The purchase rights represented by each Warrant


<PAGE>



Certificate are exercisable at the option of the Holder thereof,  in whole or in
part (but not as to fractional  shares of the Common Stock).  In the case of the
purchase of less than all the Shares purchasable under any Warrant  Certificate,
the Company shall cancel said Warrant Certificate upon the surrender thereof and
shall  execute  and  deliver a new  Warrant  Certificate  of like  tenor for the
balance of the Shares purchasable thereunder.

          3.2 Cashless  Exercise.  At any time during the Warrant Exercise Term,
the Holder may, at its option,  exchange all or part of the Warrants (a "Warrant
Exchange"), into the number of Shares determined in accordance with this Section
3.2, by  surrendering  his Warrant  Certificate  at the principal  office of the
Company or at the office of its transfer agent,  accompanied by a notice stating
such  holder's  intent  to  effect  such  exchange,  the  number of Shares to be
exchanged and the date on which the Holder  requests that such Warrant  Exchange
occur (the "Notice of Exchange").  The Warrant  Exchange shall take place on the
date  specified in the Notice of Exchange  or, if later,  the date the Notice of
Exchange is received by the Company (the "Exchange Date").  Certificates for the
Shares issuable upon such Warrant Exchange and, if applicable,  a new warrant or
warrants of like tenor evidencing the balance of the Shares remaining subject to
the  Warrants,  shall be issued as of the  Exchange  Date and  delivered  to the
Holder within seven (7) days following the Exchange Date. In connection with any
Warrant Exchange, the Warrant Certificate  surrendered shall represent the right
to subscribe  for and acquire the number of Shares  (rounded to the next highest
integer) equal to (i) the number of Shares specified by the Holder in its Notice
of Exchange  (the "Total  Number")  less (ii) the number of Shares  equal to the
quotient  obtained  by  dividing  (A) the  product  of the Total  Number and the
existing Exercise Price (as hereinafter defined) by (B) the current market value
of a share of Common Stock.

     4. Issuance of Certificates.

     Upon the exercise of the  Warrants,  the issuance of  certificates  for the
Shares shall be made  forthwith  (and in any event within  three  business  days
thereafter) without charge to the Holder thereof including,  without limitation,
any tax which may be  payable  in  respect  of the  issuance  thereof,  and such
certificates  shall (subject to the provisions of Article 5 hereof) be issued in
the name of,  or in such  names  as may be  directed  by,  the  Holder  thereof;
provided,  however,  that the Company shall not be required to pay any tax which
may be payable in respect of any transfer  involved in the issuance and delivery
of any such certificates in a name other than that of the Holder and the Company
shall not be required to issue or deliver such certificates  unless or until the
person or persons requesting the issuance thereof shall have paid to the Company
the  amount of such tax or shall have  established  to the  satisfaction  of the
Company that such tax has been paid.

     The Warrant Certificates and the certificates representing the Shares shall
be executed on behalf of the Company by the manual or facsimile signature of the
present or any future

                                       -2-


<PAGE>



Chairman or Vice Chairman of the Board of Directors or Chief Executive  Officer,
President or Vice President of the Company under its corporate  seal  reproduced
thereon,  attested to by the manual or facsimile signature of the present or any
future  Secretary or Assistant  Secretary of the Company.  Warrant  Certificates
shall be dated the date of  execution  by the  Company  upon  initial  issuance,
division, exchange, substitution or transfer.

     The Warrant Certificates and, upon exercise of the Warrants,  in part or in
whole,  certificates  representing the Shares shall bear a legend  substantially
similar to the following:

     "The securities  represented by this  certificate  have not been registered
     under the  Securities  Act of 1933, as amended (the "Act"),  and may not be
     offered or sold except (i) pursuant to an effective  registration statement
     under the Act,  (ii) to the extent  applicable,  pursuant to Rule 144 under
     the Act (or any similar rule under such Act relating to the  disposition of
     securities),  or (iii) upon the delivery by the holder to the Company of an
     opinion of  counsel,  reasonably  satisfactory  to counsel to the  Company,
     stating that an exemption from registration under such Act is available."

     5. Investment Restriction.

     The Holder of a Warrant Certificate,  by its acceptance thereof,  covenants
and agrees that the Warrants are being  acquired as an investment and not with a
view to the distribution thereof.

     6. Price.

          6.1 Initial and Adjusted  Exercise Price.  The initial exercise prices
of each Warrant shall be $.25 per Share.  The adjusted  exercise  price shall be
the price which shall result from time to time from any and all  adjustments  of
the  initial  exercise  price in  accordance  with the  provisions  of Article 8
hereof.

          6.2 Exercise  Price.  The term "Exercise  Price" herein shall mean the
initial  exercise  price or the  adjusted  exercise  price,  depending  upon the
context.

     7. Registration Rights.

          7.1  Registration  Under the  Securities Act of 1933. The Warrants and
the Shares have not been  registered for purposes of public  distribution  under
the Securities Act of 1933, as amended ("the Act").

          7.2  Registrable  Securities.  As used  herein  the term  "Registrable
Security" means each of the Warrants,  the Shares and any shares of Common Stock
issued upon any stock split

                                       -3-


<PAGE>



or stock  dividend  in  respect of such  Shares;  provided,  however,  that with
respect to any particular Registrable Security,  such security shall cease to be
a Registrable  Security when, as of the date of  determination,  (i) it has been
effectively  registered  under  the  Securities  Act and  disposed  of  pursuant
thereto,  (ii)  registration  under the Securities Act is no longer required for
the immediate public  distribution of such security or (iii) it has ceased to be
outstanding.  The term  "Registrable  Securities"  means any  and/or  all of the
securities falling within the foregoing definition of a "Registrable  Security."
In the event of any merger, reorganization,  consolidation,  recapitalization or
other change in corporate  structure affecting the Common Stock, such adjustment
shall be made in the definition of  "Registrable  Security" as is appropriate in
order to prevent any dilution or enlargement  of the rights granted  pursuant to
this Article 7.

          7.3  Piggyback  Registration.  If, at any time  during the seven years
following the date of this Agreement,  the Company  proposes to prepare and file
any registration statement or post-effective  amendments thereto covering equity
or debt securities of the Company, or any such securities of the Company held by
its  shareholders  (in any such case,  other than in  connection  with a merger,
acquisition  or pursuant to Form S-8 or successor  form),  (for purposes of this
Article 7,  collectively,  a  "Registration  Statement"),  it will give  written
notice of its intention to do so by registered mail ("Notice"),  at least thirty
(30) business days prior to the filing of each such Registration  Statement,  to
all holders of the  Registrable  Securities.  Upon the written request of such a
holder (a  "Requesting  Holder"),  made within  twenty (20)  business days after
receipt of the Notice,  that the Company include any of the Requesting  Holder's
Registrable  Securities  in the  proposed  Registration  Statement,  the Company
shall,  as to each such  Requesting  Holder,  use its best efforts to effect the
registration under the Securities Act of the Registrable Securities which it has
been so requested to register ("Piggyback Registration"),  at the Company's sole
cost and expense and at no cost or expense to the Requesting Holders.


          7.4 Demand Registration.

               (a) At any time during the Warrant  Exercise  Term, any "Majority
Holder"  (as such term is defined in Section  7.4(d)  below) of the  Registrable
Securities  shall have the right  (which  right is in addition to the  piggyback
registration  rights  provided  for under  Section 7.3 hereof),  exercisable  by
written notice to the Company (the "Demand Registration  Request"),  to have the
Company  prepare  and file with the  Securities  and  Exchange  Commission  (the
"Commission"),  on one occasion,  at the sole expense of the Company (other than
the pro rata portion of  underwriting  discounts,  if any,  attributable  to the
Holder's  Registrable  Securities  and  the  expenses  of  Holder's  counsel  or
advisors),  a  Registration  Statement  and such other  documents,  including  a
prospectus,  as may be necessary (in the opinion of both counsel for the Company
and counsel for such Majority Holder), in order to comply with the provisions of
the Act, so as to permit a public offering and sale of the Registrable

                                       -4-


<PAGE>



Securities by the holders thereof, for nine (9) consecutive months.

               (b) The Company  covenants  and agrees to give written  notice of
any Demand  Registration  Request to all holders of the  Registrable  Securities
within ten (10) days from the date of the  Company's  receipt of any such Demand
Registration  Request.  After  receiving  notice from the Company as provided in
this Section 7.4(b),  holders of Registrable  Securities may request the Company
to include  their  Registrable  Securities in the  Registration  Statement to be
filed  pursuant  to Section  7.4(a)  hereof by  notifying  the  Company of their
decision to include such securities within ten (10) days of their receipt of the
Company's notice.

               (c) The term "Majority  Holder" as used in this Section 7.4 shall
mean any holder or any  combination  of holders of  Registrable  Securities,  if
included in such holders'  Registrable  Securities are that aggregate  number of
Shares  (including  Shares  already issued and Shares  issuable  pursuant to the
exercise  of  outstanding  Warrants)  as  would  constitute  a  majority  of the
aggregate number of Shares  (including Shares already issued and Shares issuable
pursuant  to  the  exercise  of  outstanding  Warrants)  included  in all of the
Registrable Securities.

          7.5 Covenants of the Company With Respect to Registration. The Company
covenants and agrees as follows:

               (a) In connection with any registration under Section 7.4 hereof,
the Company shall file the Registration  Statement as expeditiously as possible,
but in no event later than twenty (20)  business days  following  receipt of any
demand  therefor,  shall  use its best  efforts  to have  any such  Registration
Statements  declared  effective at the earliest possible time, and shall furnish
each  holder of  Registrable  Securities  such number of  prospectuses  as shall
reasonably  be  requested.  In connection  with the  obligations  of the Company
hereunder  to  register  a Holder's  Registrable  Securities,  the Holder  shall
furnish  the Company  such  information  concerning  the  Holder,  the  Holder's
Registrable  Securities,  and the  terms  of the  offering  of such  Registrable
Securities  by the  Holder as the  Company  may  reasonably  request in order to
comply with the provisions of the Act with respect to the Registration Statement
to be filed.

               (b) Other than fees and disbursements of counsel acting on behalf
of the  holders  of  Registrable  Securities  and the pro  rata  portion  of the
underwriting  discounts and  commissions,  if any,  attributable  to Registrable
Securities,  the Company  shall pay all costs,  fees and expenses in  connection
with all  Registration  Statements  filed  pursuant to  Sections  7.3 and 7.4(a)
hereof including,  without limitation,  the Company's legal and accounting fees,
printing expenses, and blue sky fees and expenses.

               (c) The  Company  will  take all  necessary  action  which may be
required in qualifying or registering the

                                       -5-


<PAGE>



Registrable  Securities  included in a  Registration  Statement for offering and
sale under the  securities  or blue sky laws of such states as are  requested by
the holders of such securities, provided that the Company shall not be obligated
to execute or file any general  consent to service of process or to qualify as a
foreign corporation to do business under the laws of any such jurisdiction.

               (d) The Company  shall  indemnify  any holder of the  Registrable
Securities to be sold pursuant to any Registration Statement and any underwriter
or person deemed to be an underwriter under the Act and each person, if any, who
controls such holder or underwriter or person deemed to be an underwriter within
the meaning of Section 15 of the Act or Section 20(a) of the Securities Exchange
Act of 1934, as amended  ("Exchange  Act"), from and against any and all losses,
claims,  damages,  expenses and liabilities  (including all expenses  reasonably
incurred in investigating,  preparing or defending against any claim whatsoever)
caused by any untrue  statement of a material fact contained in the Registration
Statement,  any other registration statement filed by the Company under the Act,
any post-effective amendment to such registration statements,  or any prospectus
included  therein  required to be filed or furnished by reason of this Agreement
or caused by any omission or alleged  omission to state  therein a material fact
required to be stated  therein or necessary to make the  statements  therein not
misleading,  except  insofar  as  such  losses,  claims,  damages,  expenses  or
liabilities are caused by any such untrue  statement or alleged untrue statement
or omission or alleged omission based upon information  furnished or required to
be  furnished in writing to the company by the Holder or  underwriter  expressly
for use therein;  which  indemnification  shall include each person, if any, who
controls any such Holder or  underwriter  within the meaning of the Act and each
officer, director,  employee and agent of such Holder or underwriter;  provided,
however,  that the Company  shall not be obligated to so indemnify the Holder or
any such  underwriter  or other  person  referred to above  unless the Holder or
underwriter  or  other  person,  as the case  may be,  shall  at the  same  time
indemnify the Company,  its  directors,  each officer  signing the  registration
statement and each person,  if any, who controls the Company  within the meaning
of the Act, from and against any and all losses, claims,  damages,  expenses and
liabilities  caused by any untrue  statement  or alleged  untrue  statement of a
material  fact  contained  in  the  registration  Statement,   any  registration
statement or any prospectus  required to be filed or furnished by reason of this
Agreement or caused by any omission to state therein a material fact required to
be stated  therein or necessary to make the statements  therein not  misleading,
insofar as such losses, claims,  damages,  expenses or liabilities are caused by
any  untrue  statement  or  alleged  untrue  statement  or  omission  based upon
information  furnished  in writing to the  Company by the Holder or  underwriter
expressly for use therein,  and provided,  further that the holder, each person,
if any, who  controls the holder  within the meaning of the Act, and each of the
Holder's  directors,  officers,  employees  and agents shall not be obligated to
indemnify any indemnified person pursuant to the foregoing indemnity, or to make
any contribution pursuant to

                                       -6-


<PAGE>



subparagraph  7.5(f) below, in an amount in excess of the net proceeds  received
by such holder with respect to the sale of Registrable Securities.

               (e) Promptly after receipt of notice of the  commencement  of any
action in respect of which  indemnity  may be sought  against  any  indemnifying
party under this Section 7.5, the indemnified party will notify the indemnifying
party in writing of the commencement  thereof,  and the indemnifying party will,
subject to the provisions  hereinafter stated, assume the defense of such action
(including  the  employment  of counsel  reasonably  subject  to the  provisions
hereinafter stated,  assume the defense of such action (including the employment
of counsel  reasonably  satisfactory to the indemnified party and the payment of
expenses)  insofar as such action relates to an alleged  liability in respect of
which indemnity may be sought against the indemnifying  party. After notice from
the  indemnifying  party of its  election to assume the defense of such claim or
action,  the  indemnifying  party  shall no longer by liable to the  indemnified
party  under  this  Section  7.5 for any  legal or other  expenses  subsequently
incurred by the  indemnified  party in connection with the defense thereof other
than  reasonable  costs of  investigation;  provided,  however,  that if, in the
written opinion of counsel to the indemnified party or parties,  it is advisable
for the indemnified party or parties,  it is advisable for the indemnified party
or parties to be  represented  by separate  counsel,  the  indemnified  party or
parties  shall  have the  right to  employ a single  counsel  to  represent  the
indemnified  parties who may be subject to liability arising out of any claim in
respect of which  indemnity  may be sought by the  indemnified  parties  thereof
against the indemnifying  party, in which event the reasonable fees and expenses
of such separate  counsel shall be borne by the  indemnifying  party.  Any party
against whom  indemnification  may be sought under this Section 7.5 shall not be
liable to  indemnify  any person that might  otherwise be  indemnified  pursuant
hereto for any  settlement  of any action  effected  without  such  indemnifying
party's consent, which consent shall not be unreasonably withheld.

               (f) If for any reason the  indemnification  provided  for in this
Section 7.5 is held by a court of competent jurisdiction to be unavailable to an
indemnified party with respect to any loss, claim, damage,  expense or liability
referred to therein,  then the indemnifying  party, in lieu of indemnifying such
indemnified party thereunder,  shall contribute to the amount paid or payable by
th  indemnified  party as a result  of such  loss,  claim,  damage,  expense  or
liability in such  proportion as is appropriate to reflect not only the relative
benefits received by the indemnified party and the indemnifying  party, but also
the relative fault of the indemnified party and the indemnifying  party, as well
as any other relevant equitable considerations.

               (g) Nothing  contained  in this  Agreement  shall be construed as
requiring any Holder to exercise his Warrants prior to the initial filing of any
Registration Statement or the effectiveness thereof.


                                       -7-


<PAGE>



     8. Adjustments of Exercise Price and Number of Shares.

          8.1 Computation of Adjusted Price. Except as hereinafter  provided, in
case the  Company  shall at any time  after  the date  hereof  issue or sell any
shares of Common Stock (other than the issuances or sales referred to in Section
8.6  hereof),  including  shares held in the  Company's  treasury  and shares of
Common  Stock  issued upon the  exercise of any  options,  rights or warrants to
subscribe  for shares of Common  Stock  (other  than the  issuances  or sales of
Common Stock  pursuant to rights to subscribe for such Common Stock  distributed
to all the  shareholders  of the Company  and  Holders of  Warrants  pursuant to
Section  8.8  hereof)  and  shares of Common  Stock  issued  upon the  direct or
indirect  conversion or exchange of securities for shares of Common Stock, for a
consideration   per  share  less  than  either  the  Exercise  Price  in  effect
immediately  prior to the issuance or sale of such shares or the "Market  Price"
(as  defined in Section  8.1(vi)  hereof)  per share of Common  Stock or without
consideration,  then  forthwith  upon such issuance or sale,  the Exercise Price
shall (until another such issuance or sale), be reduced to the price (calculated
to the nearest  full cent)  equal to the  quotient  derived by  dividing  (A) an
amount  equal to the sum of (X) the product of (a) the total number of shares of
Common Stock outstanding  immediately prior to such issuance or sale, multiplied
by (b) the lower of (i) the Exercise Price in effect  immediately  prior to such
issuance or sale or (ii) the "Market  Price" (as defined in  subsection  (vi) of
this Section 8.1 hereof) per share of Common Stock on the date immediately prior
to the issuance or sale of such shares, plus, (Y) the aggregate of the amount of
all  consideration,  if any, received by the Company upon such issuance or sale,
by (B) the total number of shares of Common Stock outstanding  immediately after
such issuance or sale;  provided,  however,  that in no event shall the Exercise
Price be  adjusted  pursuant to this  computation  to an amount in excess of the
Exercise Price in effect  immediately prior to such  computation,  except in the
case of a combination  of  outstanding  shares of Common  Stock,  as provided by
Section 8.3 hereof. For the purposes of any computation to be made in accordance
with this Section 8.1, the following provisions shall be applicable: (i) In case
of the  issuance or sale of shares of Common Stock for a  consideration  part or
all of which shall be cash, the amount of the cash consideration  therefor shall
be deemed to be the amount of cash  received by the Company for such shares (or,
if shares of Common  Stock are  offered by the  Company  for  subscription,  the
subscription  price,  or, if such  securities  shall be sold to  underwriters or
dealers for public offering without a subscription  offering, the initial public
offering price) before  deducting  therefrom any  compensation  paid or discount
allowed in the sale, underwriting or purchase thereof by underwriters or dealers
or others performing  similar  services,  or any expenses incurred in connection
therewith.

               (ii)  In  case  of the  issuance  or  sale  (otherwise  than as a
dividend or other  distribution on any stock of the Company) of shares of Common
Stock for a consideration

                                       -8-


<PAGE>



part or all of which shall be other than cash,  the amount of the  consideration
therefor  other than cash shall be deemed to be the value of such  consideration
as determined in good faith by the Board of Directors of the Company.

               (iii) Shares of Common Stock issuable by way of dividend or other
distribution  on any stock of the  Company  shall be deemed to have been  issued
immediately  after the opening of business on the day  following the record date
for the determination of shareholders entitled to receive such dividend or other
distribution and shall be deemed to have been issued without consideration.

               (iv) The reclassification of securities of the Company other than
shares of Common Stock into securities including shares of Common Stock shall be
deemed  to  involve  the   issuance  of  such  shares  of  Common  Stock  for  a
consideration  other than cash immediately prior to the close of business on the
date fixed for the  determination  of security  holders entitled to receive such
shares,  and the value of the  consideration  allocable to such shares of Common
Stock shall be determined as provided in subsection (ii) of this Section 8.1.

               (v) The  number  of  shares  of  Common  Stock  at any  one  time
outstanding shall include the aggregate number of shares issued or issuable upon
the exercise of options, rights, warrants and upon the conversion or exchange of
convertible or exchangeable securities.

               (vi) As used herein,  the phrase "Market Price" at any date shall
be deemed to be the last reported sale price,  or, in case no such reported sale
takes place on such day,  the average of the last  reported  sale prices for the
last three trading days, in either case as officially  reported by the principal
securities  exchange on which the Common  Stock is listed or admitted to trading
or as reported in the NASDAQ National Market System,  or, if the Common Stock is
not listed or admitted to trading on any national  securities exchange or quoted
on the NASDAQ National Market System,  the closing bid price as furnished by the
National  Association  of Securities  Dealers,  Inc.  through  NASDAQ or similar
organization if NASDAQ is no longer reporting such information, or if the Common
Stock is not quoted on NASDAQ,  as determined in good faith by resolution of the
Board of Directors of the Company, based on the best information available to it
for the two days immediately preceding such issuance or sale and the day of such
issuance or sale.

          8.2  Options,   Rights,  Warrants  and  Convertible  and  Exchangeable
Securities.  Except in the case of the Company  issuing  rights to subscribe for
shares of Common Stock  distributed to all the  shareholders  of the Company and
Holders of Warrants  pursuant to Section 8.8 hereof, if the Company shall at any
time after the date hereof issue  options,  rights or warrants to subscribe  for
shares of Common Stock, or issue any securities convertible into or exchangeable
for shares of Common Stock, (i) for a consideration  per share less than (a) the
Exercise  Price in effect  immediately  prior to the  issuance of such  options,
rights

                                       -9-


<PAGE>



or warrants, or such convertible or exchangeable  securities,  or (b) the Market
Price, or (ii) without  consideration,  the Exercise Price in effect immediately
prior to the issuance of such options,  rights or warrants,  or such convertible
or  exchangeable  securities,  as the case may be,  shall be  reduced to a price
determined by making a computation in accordance  with the provisions of Section
8.1 hereof, provided that:

               (a) The aggregate  maximum  number of shares of Common Stock,  as
the case may be, issuable under all the outstanding options,  rights or warrants
shall be deemed to be issued  and  outstanding  at the time all the  outstanding
options,  rights or warrants were issued,  and for a consideration  equal to the
minimum purchase price per share provided for in the options, rights or warrants
at the time of issuance,  plus the consideration  (determined in the same manner
as consideration  received on the issue or sale of shares in accordance with the
terms of the Warrants),  if any, received by the Company for the options, rights
or  warrants,  and if no minimum  price is  provided in the  options,  rights or
warrants, then the consideration shall be equal to zero; provided, however, that
upon the expiration or other termination of the options,  rights or warrants, if
any thereof shall not have been exercised,  the number of shares of Common Stock
deemed to be issued and outstanding pursuant to this subsection (a) (and for the
purposes  of  subsection  (v) of Section  8.1  hereof)  shall be reduced by such
number of shares as to which options,  warrants and/or rights shall have expired
or terminated  unexercised,  and such number of shares shall no longer be deemed
to be issued  and  outstanding,  and the  Exercise  Price  then in effect  shall
forthwith be readjusted and thereafter be the price which it would have been had
adjustment been made on the basis of the issuance only of shares actually issued
or issuable upon the exercise of those  options,  rights or warrants as to which
the exercise rights shall not have expired or terminated unexercised.

               (b) The  aggregate  maximum  number of  shares  of  Common  Stock
issuable  upon  conversion  or  exchange  of  any  convertible  or  exchangeable
securities  shall be deemed to be issued and outstanding at the time of issuance
of  such  securities,  and  for  a  consideration  equal  to  the  consideration
(determined in the same manner as consideration received on the issue or sale of
shares of Common Stock in accordance with the terms of the Warrants) received by
the  Company  for such  securities,  plus  the  minimum  consideration,  if any,
receivable  by the Company upon the  conversion or exchange  thereof;  provided,
however,  that upon the  termination  of the right to convert or  exchange  such
convertible  or  exchangeable  securities  (whether by reason of  redemption  or
otherwise), the number of shares deemed to be issued and outstanding pursuant to
this  subsection  (b) (and for the  purpose of  subsection  (v) of  Section  8.1
hereof) shall be reduced by such number of shares as to which the  conversion or
exchange rights shall have expired or terminated unexercised, and such number of
shares shall no longer be deemed to be issued and  outstanding  and the Exercise
Price then in effect shall  forthwith be readjusted  and thereafter be the price
which it would have been had  adjustment  been made on the basis of the issuance
only of the shares  actually  issued or issuable upon the conversion or exchange
of

                                      -10-


<PAGE>



those  convertible  or  exchangeable  securities  as to which the  conversion or
exchange rights shall not have expired or terminated unexercised.

               (c) If any change shall occur in the price per share provided for
in any of the options,  rights or warrants referred to in subsection (a) of this
Section  8.2, or in the price per share at which the  securities  referred to in
subsection (b) of this Section 8.2 are convertible or exchangeable, the options,
rights or warrants or conversion or exchange  rights,  as the case may be, shall
be deemed to have  expired  or  terminated  on the date when such  price  change
became  effective in respect of shares not  theretofore  issued  pursuant to the
exercise or conversion or exchange  thereof,  and the Company shall be deemed to
have issued upon such date new  options,  rights or warrants or  convertible  or
exchangeable  securities  at the new price in  respect  of the  number of shares
issuable upon the exercise of such options, rights or warrants or the conversion
or exchange of such convertible or exchangeable securities.

          8.3 Subdivision and Combination. In case the Company shall at any time
subdivide or combine the outstanding  shares of Common Stock, the Exercise Price
shall  forthwith  be  proportionately  decreased in the case of  subdivision  or
increased in the case of combination.

          8.4  Adjustment  in Number of  Shares.  Upon  each  adjustment  of the
Exercise  Price  pursuant  to the  provisions  of this  Article 8, the number of
Shares  issuable  upon the  exercise  of each  Warrant  shall be adjusted to the
nearest full Share by multiplying a number equal to the Exercise Price in effect
immediately  prior to such  adjustment  by the  number of Shares  issuable  upon
exercise of the Warrants  immediately  prior to such adjustment and dividing the
product so obtained by the adjusted Exercise Price.

          8.5  Reclassification,  Consolidation,  Merger,  etc.  In  case of any
reclassification or change of the outstanding shares of Common Stock (other than
a change in par value to no par value,  or from no par value to par value, or as
a result of a subdivision or combination),  or in the case of any  consolidation
of the Company with, or merger of the Company into,  another  corporation (other
than a consolidation or merger in which the Company is the surviving corporation
and which does not result in any  reclassification  or change of the outstanding
shares  of  Common  Stock,  except a  change  as a result  of a  subdivision  or
combination of such shares or a change in par value,  as  aforesaid),  or in the
case of a sale or  conveyance  to another  corporation  of the  property  of the
Company as an entirety,  the Holders shall thereafter have the right to purchase
the kind and  number  of  shares of stock  and  other  securities  and  property
receivable upon such reclassification,  change,  consolidation,  merger, sale or
conveyance  as if the  Holders  were the  owners of the  shares of Common  Stock
underlying the Warrants immediately prior to any such events at a price equal to
the product of (x) the number of shares  issuable  upon exercise of the Warrants
and (y) the Exercise Price in effect immediately prior to the record

                                      -11-


<PAGE>



date  for  such  reclassification,   change,  consolidation,   merger,  sale  or
conveyance as if such Holders had exercised the Warrants.

          8.6 No Adjustment of Exercise Price in Certain Cases. No adjustment of
the Exercise Price shall be made:

          (a) Upon the  issuance  or sale of  shares of  Common  Stock  upon the
     exercise of the Warrants;

          (b)  Upon  (i) the  issuance  of  options  pursuant  to the  Company's
     employee  stock  option plan in effect on the date hereof or [any  employee
     stock  option plan  adopted  after the date hereof by  stockholders  of the
     Company]  the issuance or sale by the Company of any shares of Common Stock
     pursuant to the exercise of any such options,  or (ii) the issuance or sale
     by the Company of any shares of Common  Stock  pursuant to the  exercise of
     any  options or  warrants  previously  issued and  outstanding  on the date
     hereof;

          (c) Upon  issuance of any shares of Common Stock sold in the Company's
     offerings  of an  aggregate  of  4,000,000  shares  of Common  Stock  being
     conducted pursuant to the Company's Confidential Private Offering Memoranda
     dated AApril 20, 1995 and April 21, 1995, respectively; or

          (d) Upon the issuance of any shares of Common Stock in connection with
     the Company's merger with AccuMed, Inc.


          8.7  Dividends  and Other  Distributions  with Respect to  Outstanding
Securities.  In the  event  that the  Company  shall  at any  time  prior to the
exercise of all Warrants  declare a dividend  (other than a dividend  consisting
solely of shares of Common Stock or a cash dividend or distribution  payable out
of current or retained earnings) or otherwise distribute to its shareholders any
monies, assets, property,  rights, evidences of indebtedness,  securities (other
than shares of Common Stock), whether issued by the Company or by another person
or entity, or any other thing of value, the Holder or Holders of the unexercised
Warrants shall thereafter be entitled, in addition to the shares of Common Stock
or other securities  receivable upon the exercise thereof, to receive,  upon the
exercise of such Warrants, the same monies, property,  assets, rights, evidences
of  indebtedness,  securities  or any other  thing of value that they would have
been  entitled to receive at the time of such dividend or  distribution.  At the
time of any such dividend or  distribution,  the Company shall make  appropriate
reserves to ensure the timely  performance of the provisions of this  Subsection
8.7.

          8.8   Subscription   Rights  for  Shares  of  Common  Stock  or  Other
Securities.  In the case the Company or an affiliate of the Company shall at any
time after the date hereof and prior to the exercise of all the  Warrants  issue
any rights to

                                      -12-


<PAGE>



subscribe  for shares of Common Stock or any other  securities of the Company or
of such  affiliate to all the  shareholders  of the Company,  the Holders of the
unexercised  Warrants  shall be  entitled,  in  addition to the shares of Common
Stock or other  securities  receivable  upon the  exercise of the  Warrants,  to
receive  such  rights  at the time  such  rights  are  distributed  to the other
shareholders of the Company.

     9. Exchange and Replacement of Warrant Certificates.

     Each  Warrant  Certificate  is  exchangeable  without  expense,   upon  the
surrender hereof by the registered  Holder at the principal  executive office of
the Company,  for a new Warrant  Certificate of like tenor and date representing
in the  aggregate  the  right to  purchase  the same  number  of  Shares in such
denominations  as shall be designated by the Holder  thereof at the time of such
surrender.

     Upon receipt by the Company of evidence  reasonably  satisfactory  to it of
the loss, theft,  destruction or mutilation of any Warrant Certificate,  and, in
case of  loss,  theft  or  destruction,  of  indemnity  or  security  reasonably
satisfactory to it, and reimbursement to the Company of all reasonable  expenses
incidental  thereto,  and upon surrender and  cancellation  of the Warrants,  if
mutilated,  the Company will make and deliver a new Warrant  Certificate of like
tenor, in lieu thereof.

     10. Elimination of Fractional Interests.

     The  Company  shall  not be  required  to issue  certificates  representing
fractions  of shares of Common Stock and shall not be required to issue scrip or
pay cash in lieu of  fractional  interests,  it being the intent of the  parties
that all fractional interests shall be eliminated by rounding any fraction up to
the nearest whole number of shares of Common Stock.

     11. Reservation and Listing of Securities.

     The  Company  shall at all  times  reserve  and keep  available  out of its
authorized  shares of Common Stock,  solely for the purpose of issuance upon the
exercise  of the  Warrants,  such  number of shares of Common  Stock as shall be
issuable upon the exercise thereof.  The Company covenants and agrees that, upon
exercise of the Warrants and payment of the Exercise Price therefor,  all shares
of Common Stock  issuable upon such exercise  shall be duly and validly  issued,
fully  paid,  non-assessable  and not  subject to the  preemptive  rights of any
shareholder. As long as the Warrants shall be outstanding, the Company shall use
its best efforts to cause all shares of Common Stock  issuable upon the exercise
of the  Warrants to be listed on or quoted by NASDAQ or listed on such  national
securities exchanges as requested by Commonwealth.

     12. Notices to Warrant Holders.

     Nothing  contained in this Agreement  shall be construed as conferring upon
the Holder or Holders the right to vote or to

                                      -13-


<PAGE>



consent or to receive  notice as a  shareholder  in respect of any  meetings  of
shareholders for the election of directors or any other matter, or as having any
rights  whatsoever as a shareholder  of the Company.  If,  however,  at any time
prior to the expiration of the Warrants and their exercise, any of the following
events shall occur:

          (a) the  Company  shall take a record of the  holders of its shares of
     Common  Stock for the  purpose of  entitling  them to receive a dividend or
     distribution  payable  otherwise  than  in  cash,  or a  cash  dividend  or
     distribution payable otherwise than out of current or retained earnings, as
     indicated by the accounting  treatment of such dividend or  distribution on
     the books of the Company; or

          (b) the Company shall offer to all the holders of its Common Stock any
     additional shares of capital stock of the Company or securities convertible
     into or  exchangeable  for shares of capital  stock of the Company,  or any
     option, right or warrant to subscribe therefor; or

          (c) a  dissolution,  liquidation  or winding up of the Company  (other
     than in  connection  with a  consolidation  or  merger) or a sale of all or
     substantially all of its property, assets and business as an entirety shall
     be proposed;

then, in any one or more of said events,  the Company shall give written  notice
of such  event at least  fifteen  (15) days  prior to the date fixed as a record
date or the date of closing  the  transfer  books for the  determination  of the
shareholders   entitled  to  such   dividend,   distribution,   convertible   or
exchangeable securities or subscription rights, options or warrants, or entitled
to vote on such  proposed  dissolution,  liquidation,  winding up or sale.  Such
notice shall specify such record date or the date of closing the transfer books,
as the case may be.  Failure to give such notice or any defect therein shall not
affect the validity of any action taken in connection  with the  declaration  or
payment of any such dividend or distribution, or the issuance of any convertible
or exchangeable  securities or subscription rights,  options or warrants, or any
proposed dissolution, liquidation, winding up or sale.

     13. Notices.

     All notices, requests, consents and other communications hereunder shall be
in writing and shall be deemed to have been duly made when delivered,  or mailed
by registered or certified mail, return receipt requested:

          (a) If to a registered Holder of the Warrants,  to the address of such
Holder as shown on the books of the Company; or


                                      -14-


<PAGE>



          (b) If to the  Company,  to the address set forth in Section 3 of this
Agreement or to such other address as the Company may designate by notice to the
Holders.

     14. Supplements and Amendments.

     The Company and Commonwealth may from time to time supplement or amend this
Agreement  without the approval of any Holders of Warrant  Certificates in order
to cure any ambiguity,  to correct or supplement any provision  contained herein
which may be defective or inconsistent  with any provisions  herein,  or to make
any other provisions in regard to matters or questions  arising  hereunder which
the Company and  Commonwealth  may deem  necessary  or  desirable  and which the
Company and  Commonwealth  deem not to  adversely  affect the  interests  of the
Holders of Warrant Certificates.


     15. Successors.

     All the covenants and provisions of this Agreement by or for the benefit of
the Company and the Holders inure to the benefit of their respective  successors
and assigns hereunder.

     16. Termination.

     This  Agreement  shall  terminate  at the close of business on December 31,
2002.  Notwithstanding  the  foregoing,  this  Agreement  will  terminate on any
earlier date when all Warrants have been  exercised and all the Shares  issuable
upon exercise of the Warrants have been resold to the public; provided, however,
that the  provisions  of Section 7.5 shall  survive such  termination  until the
close of business on December 31, 2005.

     17. Governing Law.

     This  Agreement  and each Warrant  Certificate  issued  hereunder  shall be
deemed to be a contract made under the laws of the State of New York and for all
purposes shall be construed in accordance with the laws of said State.

     18. Benefits of This Agreement.

     Nothing  in this  Agreement  shall be  construed  to give to any  person or
corporation  other than the Company and  Commonwealth  and any other  registered
holder or holders of the Warrant Certificates,  Warrants or the Shares any legal
or equitable  right,  remedy or claim under this  Agreement;  and this Agreement
shall be for the sole and exclusive  benefit of the Company and Commonwealth and
any other holder or holders of the Warrant Certificates, Warrants or the Shares.







                                      -15-


<PAGE>




     19. Counterparts.

     This  Agreement may be executed in any number of  counterparts  and each of
such counterparts  shall for all purposes be deemed to be an original,  and such
counterparts shall together constitute but one and the same instrument.

     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
duly executed, as of the day and year first above written.


[SEAL]                                      ALAMAR BIOSCIENCES, INC.


                                            By:_________________________________
                                                Name:  Kenneth D. Miller
                                                Title: Chief Executive Officer

Attest:

___________________________

                                            COMMONWEALTH ASSOCIATES
                                            By: Commonwealth Associates
                                                Management Company, Inc.,
                                                General Partner


                                            By:_________________________________
                                                Name:
                                                Title:



                                      -16-


<PAGE>




THE WARRANTS  REPRESENTED BY THIS CERTIFICATE AND THE OTHER SECURITIES  ISSUABLE
UPON EXERCISE THEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED (THE "ACT"), AND MAY NOT BE OFFERED OR SOLD EXCEPT (i) PURSUANT TO AN
EFFECTIVE  REGISTRATION  STATEMENT UNDER THE ACT, (ii) TO THE EXTENT APPLICABLE,
PURSUANT TO RULE 144 UNDER SUCH ACT (OR ANY SIMILAR RULE UNDER SUCH ACT RELATING
TO THE DISPOSITION OF  SECURITIES),  OR (iii) UPON THE DELIVERY BY THE HOLDER TO
THE COMPANY OF AN OPINION OF COUNSEL, REASONABLY SATISFACTORY TO COUNSEL FOR THE
COMPANY,  STATING  THAT  AN  EXEMPTION  FROM  REGISTRATION  UNDER  SUCH  ACT  IS
AVAILABLE.

THE  TRANSFER OR EXCHANGE OF THE WARRANTS  REPRESENTED  BY THIS  CERTIFICATE  IS
RESTRICTED IN ACCORDANCE WITH THE WARRANT AGREEMENT REFERRED TO HEREIN.

                            EXERCISABLE ON OR BEFORE
                5:00 P.M., NEW YORK CITY TIME, DECEMBER 31, 1999

No. W-__                                                        420,000 Warrants

                               WARRANT CERTIFICATE

     This   Warrant   Certificate   certifies   that   Commonwealth   Associates
("Commonwealth")  or registered  assigns,  is the  registered  holder of 420,000
Warrants to  purchase,  at any time from  December  31, 1994 until 5:00 P.M. New
York City time on December 31, 1999 (the "Expiration Date") up to 420,000 shares
("Shares") of fully-paid and non-assessable  common stock, no par value ("Common
Stock"), of Alamar BioSciences,  Inc., a California corporation (the "Company"),
at the initial  exercise  price,  subject to adjustment  in certain  events (the
"Exercise Price"), of $.25 per Share, upon surrender of this Warrant Certificate
and payment of the  Exercise  Price at an office or agency of the  Company,  but
subject to the conditions set forth herein and in the warrant agreement dated as
of  December  31,  1994  between the  Company  and  Commonwealth  (the  "Warrant
Agreement").  Payment  of the  Exercise  Price may be made in cash,  or by check
payable to the order of the Company, or any combination of cash or check.

     No Warrant may be  exercised  after 5:00 P.M.,  New York City time,  on the
Expiration Date, at which time all Warrants  evidenced hereby,  unless exercised
prior thereto, shall thereafter be void.

     The  Warrants  evidenced  by this  Warrant  Certificate  are part of a duly
authorized  issue of Warrants  issued pursuant to the Warrant  Agreement,  which
Warrant Agreement is hereby incorporated by reference in and made a part of this
instrument and is hereby referred to in a description of the rights,  limitation
of rights, obligations,  duties and immunities thereunder of the Company and the
holders  (the words  "holders"  or "holder"  meaning the  registered  holders or
registered holder) of the Warrants.

     The Warrant Agreement  provides that upon the occurrence of certain events,
the Exercise Price and/or number of the Company's  securities issuable thereupon
may,  subject to certain  conditions,  be adjusted.  In such event,  the Company
will, at the request of the holder, issue a new Warrant Certificate evidencing


<PAGE>



the  adjustment  in the Exercise  Price and the number and/or type of securities
issuable upon the exercise of the Warrants;  provided, however, that the failure
of the  Company  to issue  such new  Warrant  Certificates  shall not in any way
change, alter, or otherwise impair, the rights of the holder as set forth in the
Warrant Agreement.

     Upon  due  presentment  for   registration  of  transfer  of  this  Warrant
Certificate at an office or agency of the Company, a new Warrant  Certificate or
Warrant Certificates of like tenor and evidencing in the aggregate a like number
of Warrants  shall be issued to the  transferee(s)  in exchange for this Warrant
Certificate,  subject to the  limitations  provided  herein  and in the  Warrant
Agreement,  without any charge except for any tax, or other governmental  charge
imposed in connection therewith.

     Upon the  exercise  of less  than  all of the  Warrants  evidenced  by this
Certificate,  the  Company  shall  forthwith  issue to the  holder  hereof a new
Warrant Certificate representing such number of unexercised Warrants.

     The  Company  may deem and treat  the  registered  holder(s)  hereof as the
absolute owner(s) of this Warrant Certificate  (notwithstanding  any notation of
ownership  or other  writing  hereon  made by  anyone),  for the  purpose of any
exercise hereof,  and of any distribution to the holder(s)  hereof,  and for all
other  purposes,  and the  Company  shall not be  affected  by any notice to the
contrary.

     All terms used in this Warrant Certificate which are defined in the Warrant
Agreement shall have the meanings assigned to them in the Warrant Agreement.

     IN WITNESS WHEREOF,  the Company has caused this Warrant  Certificate to be
duly executed under its corporate seal.

Dated:  As of December 31, 1994                         ALAMAR BIOSCIENCES, INC.

[SEAL]                                                  By:_____________________
                                                            Name:
                                                            Title:
Attest:

_________________________


<PAGE>



                         [FORM OF ELECTION TO PURCHASE]

     The  undersigned   hereby   irrevocably   elects  to  exercise  the  right,
represented  by this  Warrant  Certificate,  to  purchase  _________  Shares and
herewith tenders in payment for such Shares cash or a check payable to the order
of Alamar  Biosciences,  Inc.  in the amount of $ , all in  accordance  with the
terms hereof.  The  undersigned  requests that a certificate  for such Shares be
registered in the name of , whose address is  __________________,  and that such
Certificate be delivered to __________________, whose address is _____________.


Dated:                                               Signature:

                                                     (Signature  must conform in
                                                     all  respects  to  name  of
                                                     holder as  specified on the
                                                     face    of   the    Warrant
                                                     Certificate.)


                                         ________________________________

                                         ________________________________
                                         (Insert Social Security or Other
                                          Identifying Number of Holder)



<PAGE>



                              [FORM OF ASSIGNMENT]

             (To be executed by the registered holder if such holder
                  desires to transfer the Warrant Certificate.)


     FOR VALUE RECEIVED_________________________________________________________
hereby sells, assigns and transfers unto

________________________________________________________________________________
(Please print name and address of transferee)

this Warrant  Certificate,  together with all right, title and interest therein,
and does hereby irrevocably constitute and appoint _______________, Attorney, to
transfer  the  within  Warrant  Certificate  on the  books  of the  within-named
Company, with full power of substitution.


Dated:                                            Signature:____________________

                                                  (Signature must conform in all
                                                  respects to name of holder as
                                                  specified on the face of the
                                                  Warrant Certificate)


_______________________________

_______________________________
(Insert Social Security or Other
Identifying Number of Assignee)

            WARRANT  AGREEMENT  dated as of December  28,  1995,  by and between
AccuMed  International,  Inc.,  a  Delaware  corporation  (the  "Company"),  and
Commonwealth Associates, a New York limited partnership ("Commonwealth").



                             W I T N E S S E T H:

     WHEREAS,  the Company  proposes  to issue to  Commonwealth  a warrant  (the
"Warrant")  to  purchase  up to 750,000  shares  (the  "Warrant  Shares") of the
Company's Common Stock, par value $.01 per share (the "Common Stock"); and

     WHEREAS,  the Warrant issued  pursuant to this Agreement is being issued by
the Company to Commonwealth  and/or its designees in  consideration  for certain
services  performed by  Commonwealth  in connection  with the merger of AccuMed,
Inc. with and into the Company.

     NOW, THEREFORE, in consideration of the premises, the agreements herein set
forth and other good and valuable consideration,  the receipt and sufficiency of
which are hereby acknowledged, the parties hereto agree as follows:

     1. Grant. On the terms and subject to the conditions set forth herein,  and
unless this agreement is terminated prior to exercise in accordance with Section
16 hereof,  Commonwealth  and/or its  designees  is hereby  granted the right to
purchase,  at any time from December 28, 1995 until 5:00 P.M., New York time, on
December 28, 2000 (the "Warrant Exercise Term"), up to 750,000 Warrant Shares at
an initial  exercise  price  (subject  to  adjustment  as  provided in Article 8
hereof) of $1.25 per Warrant Share.

     2. Warrant Certificate. The warrant certificate (the "Warrant Certificate")
delivered and to be delivered  pursuant to this  Agreement  shall be in the form
set  forth in  Exhibit  A  attached  hereto  and made a part  hereof,  with such
appropriate  insertions,  omissions,   substitutions  and  other  variations  as
required or permitted by this Agreement.

     3. Exercise of Warrant.  The Warrant initially is exercisable at a price of
$1.25  per  Warrant  Share,  payable  in cash or by  check  to the  order of the
Company, or any combination of cash or check,  subject to adjustment as provided
in Article 8 hereof.  Upon surrender of the Warrant Certificate with the annexed
Form of  Election  to  Purchase  duly  executed,  together  with  payment of the
Exercise Price (as hereinafter defined) for the Warrant Shares purchased, at the
Company's principal offices (currently located at 920 N. Franklin Street,  Suite
402,  Chicago,  Illinois 60610)  Commonwealth (or other registered holder of the
Warrant  Certificate)  (the "Holder") shall be entitled to receive a certificate
or certificates for the Warrant Shares so pur-

                                     1

<PAGE>



chased.  The  purchase  rights  represented  by  each  Warrant  Certificate  are
exercisable  at the  option  of the  Holder,  in whole or in part (but not as to
fractional  Warrant  Shares).  In the case of the  purchase of less than all the
Warrant  Shares  purchasable  under any Warrant  Certificate,  the Company shall
cancel said Warrant Certificate upon the surrender thereof and shall execute and
deliver a new Warrant  Certificate  of like tenor for the balance of the Warrant
Shares purchasable thereunder.

     4. Issuance of Certificates.

     Upon the exercise of the  Warrants,  the issuance of  certificates  for the
Warrant Shares  purchased shall be made forthwith (and in any event within three
business  days  thereafter)  without  charge to the  Holder  thereof  including,
without  limitation,  any tax which may be payable  in  respect of the  issuance
thereof,  and such  certificates  shall  (subject to the provisions of Article 5
hereof)  be issued in the name of, or in such names as may be  directed  by, the
Holder thereof; provided, however, that the Company shall not be required to pay
any tax which may be payable in respect of any transfer involved in the issuance
and  delivery of any such  certificates  in a name other than that of the Holder
and the  Company  shall not be required  to issue or deliver  such  certificates
unless or until the person or persons requesting the issuance thereof shall have
paid to the  Company  the  amount of such tax or shall have  established  to the
satisfaction of the Company that such tax has been paid.

     The  Warrant  Certificate  and the  certificates  representing  the Warrant
Shares  shall be executed  on behalf of the  Company by the manual or  facsimile
signature of the present or any future Chairman or Vice Chairman of the Board of
Directors or President or Vice President of the Company under its corporate seal
reproduced  thereon,  attested to by the manual or  facsimile  signature  of the
present or any future  Secretary  or Assistant  Secretary  of the  Company.  The
Warrant  Certificate and  certificates  representing the Warrant Shares shall be
dated the date of  execution by the Company  upon  initial  issuance,  division,
exchange, substitution or transfer.

     Upon  exercise,  in  part  or  in  whole,  of  the  Warrants,  certificates
representing the Warrant Shares shall bear a legend substantially similar to the
following:

               "The    securities    represented   by   this
               certificate  have not been  registered  under
               the  Securities  Act of 1933, as amended (the
               "Act"), and may not be offered or sold except
               (i)  pursuant  to an  effective  registration
               statement  under the Act,  (ii) to the extent
               applicable,  pursuant  to Rule 144  under the
               Act (or  any  similar  rule  under  such  Act
               relating to the  disposition of  securities),
               or (iii) upon the delivery by the holder to

                                     2

<PAGE>



               the   Company  of  an  opinion  of   counsel,
               reasonably  satisfactory  to  counsel  to the
               issuer,   stating  that  an  exemption   from
               registration under such Act is available."

     5. Restriction on Transfer of Warrants and Warrant Shares.

     Commonwealth,  by its  acceptance  thereof,  covenants  and agrees that the
Warrant  is  being  acquired  as an  investment  and  not  with  a  view  to the
distribution  thereof,  and that  neither the Warrant  nor,  if  exercised,  any
Warrant Shares, may be directly or indirectly  offered,  transferred,  assigned,
pledged, sold or otherwise disposed of for a period of eighteen (18) months from
December 28, 1995 except with the consent of the Company.

     6. Price.

     6.1. Initial and Adjusted Exercise Price. The initial exercise price of the
Warrant shall be $1.25 per Warrant Share.  The adjusted  exercise price shall be
the price which shall result from time to time from any and all  adjustments  of
the  initial  exercise  price in  accordance  with the  provisions  of Article 8
hereof.

     6.2.  Exercise  Price.  The term  "Exercise  Price"  herein  shall mean the
initial  exercise  price or the  adjusted  exercise  price,  depending  upon the
context.

     7. Registration Rights.

     7.1.  Registration  Under the  Securities  Act of 1933. The Warrant and the
Warrant  Shares have not been  registered  for  purposes of public  distribution
under the Act.

     7.2. Registrable Securities. As used herein the term "Registrable Security"
means the Warrant  Shares and any shares of Common  Stock  issued upon any stock
split,  dividend or stock dividend in respect of the Warrant  Shares;  provided,
however, that with respect to any particular Registrable Security, such security
shall cease to be a Registrable  Security when, as of the date of determination,
(i) it has been  effectively  registered  under the Act and disposed of pursuant
thereto,  (ii)  registration  under the Act is no longer required for subsequent
public distribution of such security,  or (iii) it has ceased to be outstanding.
The term "Registrable Securities" means any and/or all of the securities falling
within the foregoing definition of a "Registrable Security." In the event of any
merger,  reorganization,  consolidation,  recapitalization  or other  change  in
corporate structure affecting the Common Stock, such adjustment shall be made in
the definition of  "Registrable  Security" as is appropriate in order to prevent
any dilution or enlargement of the rights granted pursuant to this Article 7.


                                     3

<PAGE>



     7.3.  Piggyback  Registration.  If, at any time  during the seven (7) years
following the date of this Agreement,  the Company  proposes to prepare and file
any new registration  statement or  post-effective  amendments  thereto covering
equity or debt securities of the Company,  or any such securities of the Company
held by its  shareholders  (in any such case,  other than in  connection  with a
merger,  acquisition or pursuant to Form S-8 or successor form) (for purposes of
this Article 7, collectively,  a "Company Registration Statement"), it will give
written notice (the  "Notice") of its intention to do so by registered  mail, at
least  thirty  (30)  business  days  prior to the  filing of each  such  Company
Registration Statement,  to all holders of the Registrable Securities.  Upon the
written  request of such a holder (a  "Requesting  Holder"),  made within twenty
(20) business days after receipt of the Notice,  that the Company include any of
the  Requesting  Holder's   Registrable   Securities  in  the  proposed  Company
Registration  Statement,  the Company shall, as to each such Requesting  Holder,
use its best efforts to effect the registration under the Act of the Registrable
Securities   which   it  has  been  so   requested   to   register   ("Piggyback
Registration"), at the Company's sole cost and expense and at no cost or expense
to the Requesting  Holders (except as to underwriting  discounts and commissions
and costs of individual Requesting Holders' counsel and professional advisors).

     Notwithstanding  the provisions of this Section 7.3, the Company shall have
the right at any time after it shall have given written notice  pursuant to this
Section 7.3  (irrespective  of whether any written request for inclusion of such
securities  shall have already been made) to elect not to file any such proposed
Company  Registration  Statement,  or to withdraw  the same after the filing but
prior to the effective date thereof.

     7.4 Demand Registration Right.

          (a) At any time  during  the  Warrant  Exercise  Term,  any  "Majority
Holder"  (as such term is defined in Section  7.4(c)  below) of the  Registrable
Securities  shall have the right  (which  right is in addition to the  piggyback
registration  rights)  provided for under  Section 7.3 hereof),  exercisable  by
written notice to the Company (the "Demand Registration  Request"),  to have the
Company  prepare  and file with the  Securities  and  Exchange  Commission  (the
"Commission"),  on one occasion,  at the sole expense of the Company (other than
the pro rata portion of  underwriting  discounts,  if any,  attributable  to the
Holder's  Registrable  Securities  and the  expenses  of  Holder's  counsel  and
advisors),  a  Registration  Statement  and such other  documents,  including  a
prospectus,  as may be necessary (in the opinion of both counsel for the Company
and counsel for such Majority Holder), in order to comply with the provisions of
the  Act,  so as to  permit  a  public  offering  and  sale  of the  Registrable
Securities until such time as (i) the sale of all Registrable  Securities by the
holders  thereof  or (ii)  receipt  by the  holders  thereof  of an  opinion  of
Company's counsel that the Registrable

                                     4

<PAGE>



Securities  may be  immediately  publicly  sold without  registration  under the
Securities Act.

          (b) The Company  covenants  and agrees to give  written  notice of any
Demand Registration Request to all holders of the Registrable  Securities within
ten (10)  days  from  the  date of the  Company's  receipt  of any  such  Demand
Registration  Request.  After  receiving  notice from the Company as provided in
this Section 7.4(b),  holders of Registrable  Securities may request the Company
to include  their  Registrable  Securities in the  Registration  Statement to be
filed  pursuant  to Section  7.4(a)  hereof by  notifying  the  Company of their
decision to include such securities within ten (10) days of their receipt of the
Company's notice.

          (c) The term "Majority Holder" as used in this Section 7.4 shall means
any holder or any combination of holders of Registrable Securities,  if included
in such holders'  Registrable  Securities are that  aggregate  number of Warrant
Shares  (including  Warrant Shares  already  issued and Warrant Shares  issuable
pursuant to the exercise of outstanding warrants) as would constitute a majority
of the aggregate  number of Warrant  Shares  (including  Warrant  Shares already
issued and  Warrant  Shares  issuable  pursuant to the  exercise of  outstanding
Warrants) included in all of the Registrable Securities.

     7.5  Covenants  of the Company With  Respect to  Registration.  The Company
covenants and agrees as follows:

          (a) In connection with any registration  under Section 7.4 hereof, the
Company shall file the Registration  Statement as expeditiously as possible, but
in no event later than ten (10)  business days  following  receipt of any demand
therefor,  shall use its best efforts to have any such  Registration  Statements
declared  effective at the earliest possible time, and shall furnish each holder
of Registrable  Securities such number of  prospectuses  as shall  reasonably be
requested.

          (b) The Company  shall pay all costs,  fees and expenses in connection
with all  Registration  Statements filed pursuant to Sections 7.3 and 7.4 hereof
including, without limitation, the Company's legal and accounting fees, printing
expenses, and blue sky fees and expenses,  except for any underwriting discounts
or commissions with respect to the Registrable Securities and except for fees of
counsel and other professional advisors of a holder or group of holders.

          (c) The Company will take all  necessary  action which may be required
in  qualifying  or  registering  the  Registrable   Securities   included  in  a
Registration  Statement  for offering and sale under the  securities or blue sky
laws of such states as are requested by the holders of such securities, provided
that the Company shall not be obligated to so qualify or

                                     5

<PAGE>



register the Registrable  Securities in any state that would require the Company
to execute or file any general  consent to service of process or to qualify as a
foreign corporation to do business under the laws of any such jurisdiction.

          (d)  The  Company  shall  indemnify  any  holder  of  the  Registrable
Securities to be sold pursuant to any Registration Statement and any underwriter
or person deemed to be an underwriter under the Act and each person, if any, who
controls such holder or underwriter or person deemed to be an underwriter within
the meaning of Section 15 of the Act or Section 20(a) of the Securities Exchange
Act of 1934,  as amended  ("Exchange  Act"),  against all loss,  claim,  damage,
expense  or   liability   (including   all  expenses   reasonably   incurred  in
investigating, preparing or defending against any claim whatsoever) to which any
of them may become subject under the Act, the Exchange Act or otherwise, arising
from any  untrue  statement  of a  material  fact  contained  in a  Registration
Statement,  any other registration statement filed by the Company under the Act,
any post-effective amendment to such registration statements,  or any prospectus
included  therein  required to be filed or furnished by reason of this Article 7
or caused by any omission or alleged  omission to state  therein a material fact
required to be stated  therein or necessary to make the  statements  therein not
misleading,  except insofar as such losses,  claims,  damages or liabilities are
caused by any such untrue  statement or alleged untrue  statement or omission or
alleged omission based upon information furnished or required to be furnished in
writing  to  the  Company  by  the  holder  of  the  Registrable  Securities  or
underwriter expressly for use therein;  which indemnification shall include each
person, if any, who controls any such underwriter  within the meaning of the Act
and each officer,  director,  employee and agent of such underwriter;  provided,
however,  that the Company shall not be obligated to so indemnify such holder or
any such  underwriter  or other  person  referred to above unless such holder or
underwriter  or  other  person,  as the case  may be,  shall  at the  same  time
indemnify  the  Company to the extent  required  herein.  Each person who may be
entitled to  indemnification  pursuant to the preceding sentence shall indemnify
the Company, its directors,  each officer signing the registration statement and
each person,  if any,  who  controls the Company  within the meaning of the Act,
from and against any and all losses,  claims,  damages and liabilities caused by
any untrue statement or alleged untrue statement of a material fact contained in
a Registration Statement,  any registration statement or any prospectus required
to be filed or  furnished  by reason of this Article 7 or caused by any omission
to state therein a material  fact required to be stated  therein or necessary to
make the  statements  therein not  misleading,  insofar as such losses,  claims,
damages or  liabilities  are caused by any untrue  statement  or alleged  untrue
statement or omission based upon information furnished in writing to the Company
by the Holder or underwriter expressly for use therein.


                                     6

<PAGE>



          (e) Promptly after receipt of notice of the commencement of any action
in respect of which indemnity may be sought against any indemnifying party under
this Section 7.5, the indemnified  party will notify the  indemnifying  party in
writing of the commencement thereof, and the indemnifying party will, subject to
the provisions  hereinafter stated, assume the defense of such action (including
the employment of counsel  reasonably  satisfactory to the indemnified party and
the payment of expenses)  insofar as such action relates to an alleged liability
in respect of which  indemnity  may be sought  against the  indemnifying  party.
After notice from the  indemnifying  party of its election to assume the defense
of such claim or action, the indemnifying party shall no longer be liable to the
indemnified  party  under  this  Section  7.5 for any  legal or  other  expenses
subsequently  incurred by the  indemnified  party in connection with the defense
thereof other than reasonable costs of investigation;  provided,  however,  that
if, in the written opinion of counsel to the indemnified party or parties, it is
advisable for the  indemnified  party or parties to be  represented  by separate
counsel,  the  indemnified  party or  parties  shall  have the right to employ a
single  counsel  to  represent  the  indemnified  parties  who may be subject to
liability  arising out of any claim in respect of which  indemnity may be sought
by the  indemnified  parties thereof  against the  indemnifying  party, in which
event the reasonable  fees and expenses of such separate  counsel shall be borne
by the indemnifying party. Any party against whom  indemnification may be sought
under this  Section 7.5 shall not be liable to  indemnify  any person that might
otherwise  be  indemnified  pursuant  hereto  for any  settlement  of any action
effected without such indemnifying  party's consent,  which consent shall not be
unreasonably withheld.

          (f)  If  for  any  reason  the  indemnification  provided  for  in the
preceding  subparagraph  is held  by a court  of  competent  jurisdiction  to be
unavailable to an  indemnified  party with respect to any loss,  claim,  damage,
liability or expense referred to therein,  then the indemnifying  party, in lieu
of indemnifying  such  indemnified  party  thereunder,  shall  contribute to the
amount paid or payable by the indemnified party as a result of such loss, claim,
damage or liability in such proportion as is appropriate to reflect not only the
relative benefits received by the indemnified party and the indemnifying  party,
but also the relative fault of the indemnified party and the indemnifying party,
as well as any other relevant equitable considerations.

          (g)  Nothing  contained  in  this  Agreement  shall  be  construed  as
requiring any holder to exercise the Warrant prior to the initial  filing of any
registration statement or the effectiveness thereof.



                                     7

<PAGE>



     8. Adjustments of Exercise Price and Number of Warrant Shares.

          8.1. Computation of Adjusted Price. Except as hereinafter provided, in
case the  Company  shall at any time  after  the date  hereof  issue or sell any
shares of Common Stock (other than the issuances or sales referred to in Section
8.6  hereof),  including  shares held in the  Company's  treasury  and shares of
Common  Stock  issued upon the  exercise of any  options,  rights or warrants to
subscribe  for shares of Common  Stock  (other  than the  issuances  or sales of
Common Stock  pursuant to rights to subscribe for such Common Stock  distributed
to all the  shareholders  of the Company  and  Holders of  Warrants  pursuant to
Section  8.9  hereof)  and  shares of Common  Stock  issued  upon the  direct or
indirect  conversion or exchange of securities for shares of Common Stock, for a
consideration per share less than the Exercise Price in effect immediately prior
to the  issuance  or sale of such  shares or the  "Market  Price" (as defined in
Section 8.1(iv) hereof) per share of Common Stock or without consideration, then
forthwith  upon such issuance or sale,  the Exercise  Price shall (until another
such issuance or sale) be reduced to the price  (calculated  to the nearest full
cent) equal to the  quotient  derived by dividing (A) an amount equal to the sum
of (X) the product of (a) the total number of shares of Common Stock outstanding
immediately  prior to such issuance or sale,  multiplied by (b) the lower of (i)
the Exercise Price in effect  immediately prior to such issuance or sale or (ii)
the "Market  Price" (as defined in  subsection  (vi) of this Section 8.1 hereof)
per share of Common Stock on the date immediately  prior to the issuance or sale
of such shares,  plus, (Y) the aggregate of the amount of all consideration,  if
any, received by the Company upon such issuance or sale, by (B) the total number
of shares of Common Stock  outstanding  immediately after such issuance or sale;
provided,  however,  that in no event  shall  the  Exercise  Price  be  adjusted
pursuant to this  computation  to an amount in excess of the  Exercise  Price in
effect  immediately  prior  to  such  computation,  except  in  the  case  of  a
combination  of outstanding  shares of Common Stock,  as provided by Section 8.3
hereof.

     For the  purposes of any  computation  to be made in  accordance  with this
Section 8.1, the following provisions shall be applicable:

               (i) In case of the issuance or sale of shares of Common Stock for
a  consideration  part or all of which  shall be cash,  the  amount  of the cash
consideration  therefor shall be deemed to be the amount of cash received by the
Company  for such  shares  (or,  if shares of Common  Stock are  offered  by the
Company for subscription,  the subscription  price, or, if such securities shall
be sold to underwriters  or dealers for public  offering  without a subscription
offering,  the initial public  offering  price) before  deducting  therefrom any
compensation  paid or  discount  allowed in the sale,  underwriting  or purchase
thereof

                                     8

<PAGE>



by  underwriters  or  dealers  or others  performing  similar  services,  or any
expenses incurred in connection therewith.

               (ii)  In  case  of the  issuance  or  sale  (otherwise  than as a
dividend or other  distribution on any stock of the Company) of shares of Common
Stock for a  consideration  part or all of which  shall be other than cash,  the
amount of the  consideration  therefor other than cash shall be deemed to be the
value  of such  consideration  as  determined  in good  faith  by the  Board  of
Directors of the Company.

               (iii) Shares of Common Stock issuable by way of dividend or other
distribution  on any stock of the  Company  shall be deemed to have been  issued
immediately  after the opening of business on the day  following the record date
for the determination of shareholders entitled to receive such dividend or other
distribution and shall be deemed to have been issued without consideration.

               (iv) The reclassification of securities of the Company other than
shares of Common Stock into securities including shares of Common Stock shall be
deemed  to  involve  the   issuance  of  such  shares  of  Common  Stock  for  a
consideration  other than cash immediately prior to the close of business on the
date fixed for the  determination  of security  holders entitled to receive such
shares,  and the value of the  consideration  allocable to such shares of Common
Stock shall be determined as provided in subsection (ii) of this Section 8.1.

               (v) The  number  of  shares  of  Common  Stock  at any  one  time
outstanding shall include the aggregate number of shares issued or issuable upon
the exercise of options, rights, warrants and upon the conversion or exchange of
convertible or exchangeable securities.

               (vi) The term  "Market  Price" at any date  shall be deemed to be
the last reported  sale price,  or, in case no such reported sale takes place on
such day,  the  average  of the last  reported  sale  prices  for the last three
trading days, in either case as officially reported by the principal  securities
exchange  on which the  Common  Stock is listed or  admitted  to  trading  or as
reported in the NASDAQ National  Market System,  or the NASDAQ Small Cap Market,
or, if the Common  Stock is not listed or  admitted  to trading on any  national
securities exchange or quoted on the NASDAQ National Market System or the NASDAQ
Small Cap Market, the closing bid price as furnished by the National Association
of Securities Dealers,  Inc. through NASDAQ or similar organization if NASDAQ is
no longer  reporting such  information,  or if the Common Stock is not listed or
admitted to trading on a securities  exchange or quoted on NASDAQ, as determined
in good faith by resolution  of the Board of Directors of the Company,  based on
the best information available to it for the two days immediately preceding such
issuance or sale and the day of such issuance or sale.

                                     9

<PAGE>




     8.2. Options, Rights, Warrants and Convertible and Exchangeable Securities.
Except in the case of the  Company  issuing  rights to  subscribe  for shares of
Common Stock  distributed to all the  shareholders of the Company and Holders of
Warrants pursuant to Section 8.10 hereof, if the Company shall at any time after
the date hereof issue  options,  rights or warrants to  subscribe  for shares of
Common Stock,  or issue any  securities  convertible  into or  exchangeable  for
shares of Common  Stock,  (i) for a  consideration  per share  less than (a) the
Exercise  Price in effect  immediately  prior to the  issuance of such  options,
rights or warrants, or such convertible or exchangeable  securities,  or (b) the
Market  Price,  or (ii)  without  consideration,  the  Exercise  Price in effect
immediately prior to the issuance of such options,  rights or warrants,  or such
convertible or exchangeable securities,  as the case may be, shall be reduced to
a price  determined by making a computation in accordance with the provisions of
Section 8.1 hereof, provided that:

          (a) The aggregate  maximum  number of shares of Common  Stock,  as the
case may be,  issuable  under all the  outstanding  options,  rights or warrants
shall be deemed to be issued  and  outstanding  at the time all the  outstanding
options,  rights or warrants were issued,  and for a consideration  equal to the
minimum purchase price per share provided for in the options, rights or warrants
at the time of issuance,  plus the consideration  (determined in the same manner
as consideration  received on the issue or sale of shares in accordance with the
terms of the Warrants),  if any, received by the Company for the options, rights
or  warrants,  and if no minimum  price is  provided in the  options,  rights or
warrants, then the consideration shall be equal to zero; provided, however, that
upon the expiration or other termination of the options,  rights or warrants, if
any thereof shall not have been exercised,  the number of shares of Common Stock
deemed to be issued and outstanding pursuant to this subsection (a) (and for the
purposes  of  subsection  (v) of Section  8.1  hereof)  shall be reduced by such
number of shares as to which options,  warrants and/or rights shall have expired
or terminated  unexercised,  and such number of shares shall no longer be deemed
to be issued  and  outstanding,  and the  Exercise  Price  then in effect  shall
forthwith be readjusted and thereafter be the price which it would have been had
adjustment been made on the basis of the issuance only of shares actually issued
or issuable upon the exercise of those  options,  rights or warrants as to which
the exercise rights shall not have expired or terminated unexercised.

          (b) The aggregate  maximum  number of shares of Common Stock  issuable
upon conversion or exchange of any convertible or exchangeable  securities shall
be  deemed  to be  issued  and  outstanding  at the  time  of  issuance  of such
securities,  and for a consideration  equal to the consideration  (determined in
the same  manner  as  consideration  received  on the issue or sale of shares of
Common  Stock in  accordance  with the terms of the  Warrants)  received  by the
Company for such securities, plus the minimum consideration,  if any, receivable
by

                                     10

<PAGE>



the Company upon the conversion or exchange  thereof;  provided,  however,  that
upon the  termination  of the right to convert or exchange such  convertible  or
exchangeable  securities  (whether by reason of  redemption or  otherwise),  the
number of shares deemed to be issued and outstanding pursuant to this subsection
(b) (and for the  purpose of  subsection  (v) of Section  8.1  hereof)  shall be
reduced by such number of shares as to which the  conversion or exchange  rights
shall have expired or terminated unexercised, and such number of shares shall no
longer be deemed to be issued and  outstanding  and the  Exercise  Price then in
effect shall  forthwith be readjusted and thereafter be the price which it would
have been had  adjustment  been made on the  basis of the  issuance  only of the
shares  actually  issued or issuable  upon the  conversion  or exchange of those
convertible  or  exchangeable  securities as to which the conversion or exchange
rights shall not have expired or terminated unexercised.

          (c) If any change  shall occur in the price per share  provided for in
any of the options,  rights or warrants  referred to in  subsection  (a) of this
Section  8.2, or in the price per share at which the  securities  referred to in
subsection (b) of this Section 8.2 are convertible or exchangeable, the options,
rights or warrants or conversion or exchange  rights,  as the case may be, shall
be deemed to have  expired  or  terminated  on the date when such  price  change
became  effective in respect of shares not  theretofore  issued  pursuant to the
exercise or conversion or exchange  thereof,  and the Company shall be deemed to
have issued upon such date new  options,  rights or warrants or  convertible  or
exchangeable  securities  at the new price in  respect  of the  number of shares
issuable upon the exercise of such options, rights or warrants or the conversion
or exchange of such convertible or exchangeable securities.

     8.3.  Subdivision  and  Combination.  In case the Company shall at any time
subdivide or combine the outstanding  shares of Common Stock, the Exercise Price
shall  forthwith  be  proportionately  decreased in the case of  subdivision  or
increased in the case of combination.

     8.4.  Adjustment in Number of Warrant  Shares.  Upon each adjustment of the
Exercise  Price  pursuant  to the  provisions  of this  Article 8, the number of
Warrant  Shares  issuable  upon the exercise of the Warrant shall be adjusted to
the nearest full  Warrant  Share by  multiplying  a number equal to the Exercise
Price in effect  immediately  prior to such  adjustment by the number of Warrant
Shares  issuable  upon  exercise  of  the  Warrant  immediately  prior  to  such
adjustment and dividing the product so obtained by the adjusted Exercise Price.

     8.5.  Reclassification,   Consolidation,   Merger,  etc.  In  case  of  any
reclassification or change of the outstanding shares of Common Stock (other than
a change in par value to no par value,  or from no par value to par value, or as
a result of a subdivision or combination), or in the case of any

                                     11

<PAGE>



consolidation  of the  Company  with,  or merger of the  Company  into,  another
corporation  (other than a  consolidation  or merger in which the Company is the
surviving  corporation  and which  does not  result in any  reclassification  or
change of the outstanding shares of Common Stock, except a change as a result of
a  subdivision  or  combination  of such  shares  or a change in par  value,  as
aforesaid), or in the case of a sale or conveyance to another corporation of the
property of the Company as an entirety,  the Holders shall  thereafter  have the
right to  purchase  the kind and number of shares of stock and other  securities
and  property  receivable  upon such  reclassification,  change,  consolidation,
merger,  sale or  conveyance  as if the  Holders  were the owners of the Warrant
Shares  underlying the Warrant at a price equal to the product of (x) the number
of shares of Common Stock issuable upon conversion of the Warrant Shares and (y)
the Exercise Price prior to the record date for such  reclassification,  change,
consolidation,  merger,  sale or conveyance as if such Holders had exercised the
Warrant.

     8.6. No  Adjustment  of Exercise  Price in Certain  Cases.  Notwithstanding
anything  herein to the contrary,  no adjustment of the Exercise  Price shall be
made:

          (a) Upon the issuance or sale of the Warrant or the Warrant Shares; or

          (b)  Upon  (i) the  issuance  of  options  pursuant  to the  Company's
     employee stock option plans in effect on the date hereof or the issuance or
     sale by the Company of any shares of Common Stock  pursuant to the exercise
     of any such  options,  or (ii) the  issuance  or sale by the Company of any
     shares of Common Stock  pursuant to the exercise of any options or warrants
     previously issued and outstanding on the date hereof; or

          (c) If the  amount  of said  adjustment  shall  be less  than one cent
     ($0.01) per Share, provided, however, that in such case any adjustment that
     would  otherwise be required  then to be made shall be carried  forward and
     shall  be made  at the  time  of and  together  with  the  next  subsequent
     adjustment  which,  together with any adjustment so carried forward,  shall
     amount to at least one cent ($0.01) per Share.

     8.7. Redemption of Warrant;  Redemption of Warrant Shares.  Notwithstanding
anything to the  contrary  contained  in the Warrant or  elsewhere,  the Warrant
cannot be redeemed by the Company under any circumstances.

     8.8.  Dividends  and  Other   Distributions  with  Respect  to  Outstanding
Securities.  In the  event  that the  Company  shall  at any  time  prior to the
exercise of the  Warrant  declare a dividend  (other than a dividend  consisting
solely of shares of

                                     12

<PAGE>



Common  Stock or a cash  dividend  or  distribution  payable  out of  current or
retained  earnings)  or otherwise  distribute  to its  shareholders  any monies,
assets,  property,  rights,  evidences of indebtedness,  securities  (other than
shares of Common  Stock),  whether issued by the Company or by another person or
entity,  or any other thing of value, the Holder of the Warrant shall thereafter
be entitled, in addition to the securities receivable upon the exercise thereof,
to  receive,  upon the  exercise of such  Warrant,  the same  monies,  property,
assets,  rights,  evidences of  indebtedness,  securities  or any other thing of
value that he would have been  entitled to receive at the time of such  dividend
or distribution.  At the time of any such dividend or distribution,  the Company
shall  make  appropriate  reserves  to  ensure  the  timely  performance  of the
provisions of this Subsection 8.8.

     8.9. Subscription Rights for Shares of Common Stock or Other Securities. In
the case that the Company or an affiliate of the Company shall at any time after
the date hereof and prior to the  exercise  of the  Warrant  issue any rights to
subscribe  for shares of Common Stock or any other  securities of the Company or
of such  affiliate to all the  shareholders  of the  Company,  the Holder of the
unexercised Warrant shall be entitled,  in addition to the securities receivable
upon the exercise of the Warrant, to receive such rights at the time such rights
are distributed to the other shareholders of the Company.

     9. Exchange and Replacement of Warrant Certificates.

     The Warrant Certificate is exchangeable without expense, upon the surrender
hereof  by the  registered  Holder  at the  principal  executive  office  of the
Company,  for a new Warrant  Certificate of like tenor and date  representing in
the  aggregate  the right to purchase the same number of Warrant  Shares in such
denominations  as shall be designated by the Holder  thereof at the time of such
surrender.

     Upon receipt by the Company of evidence  reasonably  satisfactory  to it of
the loss, theft,  destruction or mutilation of the Warrant Certificate,  and, in
case of  loss,  theft  or  destruction,  of  indemnity  or  security  reasonably
satisfactory to it, and reimbursement to the Company of all reasonable  expenses
incidental  thereto,  and upon  surrender and  cancellation  of the Warrant,  if
mutilated,  the Company will make and deliver a new Warrant  Certificate of like
tenor, in lieu thereof.

     10. Elimination of Fractional Interests.

            The Company shall not be required to issue certificates representing
fractions of Warrant  Shares upon the  exercise of the Warrant,  nor shall it be
required to issue scrip or pay cash in lieu of  fractional  interests,  it being
the intent of the parties that all fractional  interests  shall be eliminated by
rounding any fraction up to the nearest whole number of Warrant Shares.

                                     13

<PAGE>




     11. Reservation and Listing of Securities.

     The  Company  shall at all  times  reserve  and keep  available  out of its
authorized  shares of Common Stock,  solely for the purpose of issuance upon the
exercise  of the  Warrant,  such  number of  shares of Common  Stock as shall be
issuable  upon such  exercise.  The  Company  covenants  and agrees  that,  upon
exercise of the Warrant and payment of the Exercise Price  therefor,  all shares
of Common Stock  issuable upon such exercise  shall be duly and validly  issued,
fully  paid,  non-assessable  and not  subject to the  preemptive  rights of any
shareholder. As long as the Warrant shall be outstanding,  the Company shall use
its best efforts to cause all Warrant Shares to be listed on or quoted by NASDAQ
or listed on such national securities exchanges as the Company's Common Stock is
listed.

     12. Notices to Warrant Holder.

     Nothing  contained in this Agreement  shall be construed as conferring upon
the Holder the right to vote or to consent or to receive notice as a shareholder
in respect of any meetings of shareholders  for the election of directors or any
other  matter,  or as having  any  rights  whatsoever  as a  shareholder  of the
Company.  If,  however,  at any time prior to the expiration of the Warrants and
their exercise, any of the following events shall occur:

          (a) the  Company  shall take a record of the  holders of its shares of
     Common  Stock for the  purpose of  entitling  them to receive a dividend or
     distribution  payable  otherwise  than  in  cash,  or a  cash  dividend  or
     distribution payable otherwise than out of current or retained earnings, as
     indicated by the accounting  treatment of such dividend or  distribution on
     the books of the Company; or

          (b) the Company shall offer to all the holders of its Common Stock any
     additional shares of capital stock of the Company or securities convertible
     into or  exchangeable  for shares of capital  stock of the Company,  or any
     option, right or warrant to subscribe therefor; or

          (c) a  dissolution,  liquidation  or winding up of the Company  (other
     than in  connection  with a  consolidation  or  merger) or a sale of all or
     substantially all of its property, assets and business as an entirety shall
     be proposed;

then, in any one or more of said events,  the Company shall give written  notice
to the Holder of such event at least  fifteen  (15) days prior to the date fixed
as a record date or the date of closing the transfer books for the determination
of the shareholders entitled to such dividend, distribution, convertible

                                     14

<PAGE>



or  exchangeable  securities or  subscription  rights,  options or warrants,  or
entitled to vote on such proposed dissolution,  liquidation, winding up or sale.
Such notice  shall  specify such record date or the date of closing the transfer
books,  as the case may be.  Failure to give such  notice or any defect  therein
shall not  affect  the  validity  of any  action  taken in  connection  with the
declaration or payment of any such dividend or distribution,  or the issuance of
any convertible or exchangeable  securities or subscription  rights,  options or
warrants, or any proposed dissolution, liquidation, winding up or sale.

     13. Notices.

     All notices, requests, consents and other communications hereunder shall be
in writing and shall be deemed to have been duly made when delivered,  or mailed
by registered or certified mail, return receipt requested:

          (a) If to the registered Holder of the Warrant, to the address of such
     Holder as shown on the books of the Company; or

          (b) If to the  Company,  to the address set forth in Section 3 of this
     Agreement or to such other  address as the Company may  designate by notice
     to the Holder.

     14. Supplements and Amendments.

     The Company and Commonwealth may from time to time supplement or amend this
Agreement  without the approval of any Holder of the Warrant  and/or  securities
underlying the Warrant in order to cure any ambiguity,  to correct or supplement
any provision  contained herein which may be defective or inconsistent  with any
provisions  herein,  or to make any other  provisions  in regard to  matters  or
questions  arising  hereunder  which  the  Company  and  Commonwealth  may  deem
necessary or  desirable  and which the Company and the  Underwriter  deem not to
adversely affect the interests of the Holder of the Warrant.

     15. Successors.

     All the covenants and provisions of this Agreement by or for the benefit of
the Company and the Holder inure to the benefit of their  respective  successors
and assigns hereunder.

     16. Termination.

     This  Agreement  shall  terminate  at the close of business on September 1,
2003.  Notwithstanding  the  foregoing,  this  Agreement  will  terminate on any
earlier date when the Warrant has been exercised and all  securities  underlying
the  Warrant  have  been  resold  to the  public;  provided,  however,  that the
provisions of Section 7 shall survive such termination until the close of

                                     15

<PAGE>



business  on  September  1, 2006 with  respect  to any  outstanding  Registrable
Securities.

     17. Governing Law.

     This Agreement and the Warrant Certificate issued hereunder shall be deemed
to be a  contract  made  under  the  laws of the  State  of New York and for all
purposes shall be construed in accordance with the laws of said State.

     18. Jurisdiction; Consent to Service of Process.

          (a) The Company hereby irrevocably and  unconditionally  submits,  for
itself and its property, to the nonexclusive  jurisdiction of any New York State
court or Federal court of the United States of America sitting in the Borough of
Manhattan,  City of New York, and any appellate  court from any thereof,  in any
action or  proceeding  arising  out of or  relating  to this  Agreement,  or for
recognition or enforcement of any judgment hereon. The Company and Commonwealth,
by their acceptance of this Agreement,  hereby  irrevocably and  unconditionally
agree that all claims in respect of any such action or  proceeding  may be heard
and determined in such New York State court or, to the extent  permitted by law,
in such Federal court.  Each such party also agrees that a final judgment in any
such  action or  proceeding  shall be  conclusive  and may be  enforced in other
jurisdictions  by suit on the judgment or in any other  manner  provided by law.
Nothing in this  Agreement  shall affect any right that the Holder may otherwise
have to bring any action or proceeding  relating to this  Agreement  against the
Company or its properties in the courts of any jurisdiction.

          (b) The Company hereby irrevocably and unconditionally  waives, to the
fullest extent it may legally and  effectively do so, any objection which it may
now or hereafter  have to the laying of venue of any suit,  action or proceeding
arising out of or relating  to this  Agreement  in any New York State or Federal
court.  The Company and  Commonwealth,  by their  acceptance of this  Agreement,
hereby irrevocably waive, to the fullest extent permitted by law, the defense of
an  inconvenient  forum to the  maintenance  of such action or proceeding in any
such court.

          (c)  The  Company  and  Commonwealth,   by  their  acceptance  hereof,
irrevocably  consent to service of process in the manner provided for notices in
Section 13. Nothing in this Agreement will affect the right of any party to this
Agreement to serve process in any other manner permitted by law.

     19. Benefits of This Agreement.

     Nothing  in this  Agreement  shall be  construed  to give to any  person or
corporation  other than the Company and  Commonwealth  and any other  registered
Holder of the  Warrant or any  securities  underlying  the  Warrant any legal or
equitable right, remedy or

                                     16

<PAGE>



claim  under  this  Agreement;  and  this  Agreement  shall  be for the sole and
exclusive benefit of the Company and Commonwealth and any such other Holder.

     20. Counterparts.

     This  Agreement may be executed in any number of  counterparts  and each of
such counterparts  shall for all purposes be deemed to be an original,  and such
counterparts shall together constitute but one and the same instrument.



                                     17

<PAGE>



     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
duly executed, as of the day and year first above written.

[SEAL]                        ACCUMED INTERNATIONAL, INC.



                              By:__________________________________
                                 Name:  Peter P. Gombrich
                                 Title: Chief Executive Officer


Attest:

_________________________
Mark L. Santor
Secretary



                              COMMONWEALTH ASSOCIATES

                              By:   Commonwealth Associates Management
                                    Company, Inc., General Partner



                              By:________________________________
                                 Name:
                                 Title:



<PAGE>



EXHIBIT A

THE WARRANTS  REPRESENTED BY THIS  CERTIFICATE AND THE SECURITIES  ISSUABLE UPON
EXERCISE  THEREOF HAVE NOT BEEN REGISTERED  UNDER THE SECURITIES ACT OF 1933, AS
AMENDED  (THE  "ACT"),  AND MAY NOT BE OFFERED OR SOLD EXCEPT (i) PURSUANT TO AN
EFFECTIVE  REGISTRATION  STATEMENT UNDER THE ACT, (ii) TO THE EXTENT APPLICABLE,
PURSUANT TO RULE 144 UNDER SUCH ACT (OR ANY SIMILAR RULE UNDER SUCH ACT RELATING
TO THE DISPOSITION OF  SECURITIES),  OR (iii) UPON THE DELIVERY BY THE HOLDER TO
THE COMPANY OF AN OPINION OF COUNSEL, REASONABLY SATISFACTORY TO COUNSEL FOR THE
ISSUER, STATING THAT AN EXEMPTION FROM REGISTRATION UNDER SUCH ACT IS AVAILABLE.

THE TRANSFER OR EXCHANGE OF THE WARRANTS REPRESENTED BY THIS
CERTIFICATE IS RESTRICTED IN ACCORDANCE WITH THE WARRANT
AGREEMENT REFERRED TO HEREIN.

              EXERCISABLE AT ANY TIME FROM DECEMBER 28, 1995 UNTIL
                   5:00 P.M., NEW YORK TIME, DECEMBER 28, 2000

                                _______ Warrants

                               WARRANT CERTIFICATE

     This Warrant  Certificate  certifies that _____________  __________________
("__________"),  or registered  assigns, is the registered holder of Warrants to
purchase,  at any time from December 28, 1995 until 5:00 P.M. New York City time
on  December  28,  2000  ("Expiration  Date"),  up  to  _______  fully-paid  and
non-assessable  share(s) (the  "Shares") of Common Stock,  no par value ("Common
Stock"), of AccuMed International, Inc., a Delaware corporation (the "Company"),
at the initial  exercise  price,  subject to adjustment  in certain  events (the
"Exercise  Price"),   of  $1.25  per  share,  upon  surrender  of  this  Warrant
Certificate  and  payment  of the  Exercise  Price at an office or agency of the
Company,  but  subject to the  conditions  set forth  herein and in the  Warrant
Agreement  dated as of  December  28,  1995,  by and  between  the  Company  and
Commonwealth Associates (the "Warrant Agreement"). Payment of the Exercise Price
may be made in cash,  or by check  payable to the order of the  Company,  or any
combination of cash or check.

     No Warrant may be  exercised  after 5:00 P.M.,  New York City time,  on the
Expiration Date, at which time all Warrants  evidenced hereby,  unless exercised
prior thereto, shall thereafter be void.

     The  Warrants  evidenced  by this  Warrant  Certificate  are part of a duly
authorized  issue of Warrants  issued pursuant to the Warrant  Agreement,  which
Warrant Agreement is hereby incorporated by reference in and made a part of this
instrument and is hereby referred to in a description of the rights,  limitation
of rights, obligations,  duties and immunities thereunder of the Company and the
holders  (the words  "holders"  or "holder"  meaning the  registered  holders or
registered holder) of the Warrants.



<PAGE>



     The Warrant Agreement  provides that upon the occurrence of certain events,
the  Exercise  Price  and the type  and/or  number of the  Company's  securities
issuable  thereupon may,  subject to certain  conditions,  be adjusted.  In such
event,  the Company  will,  at the  request of the  holder,  issue a new Warrant
Certificate  evidencing  the  adjustment  in the  Exercise  Price and the number
and/or type of securities issuable upon the exercise of the Warrants;  provided,
however,  that the failure of the Company to issue such new Warrant Certificates
shall not in any way  change,  alter,  or  otherwise  impair,  the rights of the
holder as set forth in the Warrant Agreement.

     Upon  due  presentment  for   registration  of  transfer  of  this  Warrant
Certificate at an office or agency of the Company, a new Warrant  Certificate or
Warrant Certificates of like tenor and evidencing in the aggregate a like number
of Warrants  shall be issued to the  transferee(s)  in exchange for this Warrant
Certificate,  subject to the  limitations  provided  herein  and in the  Warrant
Agreement,  without any charge except for any tax, or other governmental  charge
imposed in connection therewith.

     Upon the  exercise  of less  than  all of the  Warrants  evidenced  by this
Certificate,  the  Company  shall  forthwith  issue to the  holder  hereof a new
Warrant Certificate representing such number of unexercised Warrants.

     The  Company  may deem and treat  the  registered  holder(s)  hereof as the
absolute owner(s) of this Warrant Certificate  (notwithstanding  any notation of
ownership  or other  writing  hereon  made by  anyone),  for the  purpose of any
exercise hereof,  and of any distribution to the holder(s)  hereof,  and for all
other  purposes,  and the  Company  shall not be  affected  by any notice to the
contrary.

     All terms used in this Warrant Certificate which are defined in the Warrant
Agreement shall have the meanings assigned to them in the Warrant Agreement.




<PAGE>



     IN WITNESS WHEREOF,  the Company has caused this Warrant  Certificate to be
duly executed under its corporate seal.

Dated:  December 28, 1995            ACCUMED INTERNATIONAL, INC.


[SEAL]                               By:___________________________
                                        Name:  Peter P. Gombrich
                                        Title: Chief Executive Officer


Attest:


_______________________
Mark L. Santor
Secretary






<PAGE>


THE WARRANTS  REPRESENTED BY THIS  CERTIFICATE AND THE SECURITIES  ISSUABLE UPON
EXERCISE  THEREOF HAVE NOT BEEN REGISTERED  UNDER THE SECURITIES ACT OF 1933, AS
AMENDED  (THE  "ACT"),  AND MAY NOT BE OFFERED OR SOLD EXCEPT (i) PURSUANT TO AN
EFFECTIVE  REGISTRATION  STATEMENT UNDER THE ACT, (ii) TO THE EXTENT APPLICABLE,
PURSUANT TO RULE 144 UNDER SUCH ACT (OR ANY SIMILAR RULE UNDER SUCH ACT RELATING
TO THE DISPOSITION OF  SECURITIES),  OR (iii) UPON THE DELIVERY BY THE HOLDER TO
THE COMPANY OF AN OPINION OF COUNSEL, REASONABLY SATISFACTORY TO COUNSEL FOR THE
ISSUER, STATING THAT AN EXEMPTION FROM REGISTRATION UNDER SUCH ACT IS AVAILABLE.

THE  TRANSFER OR EXCHANGE OF THE WARRANTS  REPRESENTED  BY THIS  CERTIFICATE  IS
RESTRICTED IN ACCORDANCE WITH THE WARRANT AGREEMENT REFERRED TO HEREIN.

              EXERCISABLE AT ANY TIME FROM DECEMBER 28, 1995 UNTIL
                   5:00 P.M., NEW YORK TIME, DECEMBER 28, 2000

                                750,000 Warrants

                               WARRANT CERTIFICATE

     This Warrant Certificate certifies that Commonwealth Associates, a New York
limited partnership  ("Commonwealth"),  or registered assigns, is the registered
holder of Warrants to  purchase,  at any time from  December 28, 1995 until 5:00
P.M. New York City time on December 28, 2000 ("Expiration  Date"), up to 750,000
fully-paid and  non-assessable  share(s) (the "Shares") of Common Stock,  no par
value ("Common Stock"), of AccuMed  International,  Inc., a Delaware corporation
(the "Company"), at the initial exercise price, subject to adjustment in certain
events  (the  "Exercise  Price"),  of $1.25 per share,  upon  surrender  of this
Warrant  Certificate and payment of the Exercise Price at an office or agency of
the Company,  but subject to the  conditions set forth herein and in the Warrant
Agreement  dated as of  December  28,  1995,  by and  between  the  Company  and
Commonwealth Associates (the "Warrant Agreement"). Payment of the Exercise Price
may be made in cash,  or by check  payable to the order of the  Company,  or any
combination of cash or check.

     No Warrant may be  exercised  after 5:00 P.M.,  New York City time,  on the
Expiration Date, at which time all Warrants  evidenced hereby,  unless exercised
prior thereto, shall thereafter be void.

     The  Warrants  evidenced  by this  Warrant  Certificate  are part of a duly
authorized  issue of Warrants  issued pursuant to the Warrant  Agreement,  which
Warrant Agreement is hereby incorporated by reference in and made a part of this
instrument and is hereby referred to in a description of the rights,  limitation
of rights, obligations,  duties and immunities thereunder of the Company and the
holders  (the words  "holders"  or "holder"  meaning the  registered  holders or
registered holder) of the Warrants.



<PAGE>



     The Warrant Agreement  provides that upon the occurrence of certain events,
the  Exercise  Price  and the type  and/or  number of the  Company's  securities
issuable  thereupon may,  subject to certain  conditions,  be adjusted.  In such
event,  the Company  will,  at the  request of the  holder,  issue a new Warrant
Certificate  evidencing  the  adjustment  in the  Exercise  Price and the number
and/or type of securities issuable upon the exercise of the Warrants;  provided,
however,  that the failure of the Company to issue such new Warrant Certificates
shall not in any way  change,  alter,  or  otherwise  impair,  the rights of the
holder as set forth in the Warrant Agreement.

     Upon  due  presentment  for   registration  of  transfer  of  this  Warrant
Certificate at an office or agency of the Company, a new Warrant  Certificate or
Warrant Certificates of like tenor and evidencing in the aggregate a like number
of Warrants  shall be issued to the  transferee(s)  in exchange for this Warrant
Certificate,  subject to the  limitations  provided  herein  and in the  Warrant
Agreement,  without any charge except for any tax, or other governmental  charge
imposed in connection therewith.

     Upon the  exercise  of less  than  all of the  Warrants  evidenced  by this
Certificate,  the  Company  shall  forthwith  issue to the  holder  hereof a new
Warrant Certificate representing such number of unexercised Warrants.

     The  Company  may deem and treat  the  registered  holder(s)  hereof as the
absolute owner(s) of this Warrant Certificate  (notwithstanding  any notation of
ownership  or other  writing  hereon  made by  anyone),  for the  purpose of any
exercise hereof,  and of any distribution to the holder(s)  hereof,  and for all
other  purposes,  and the  Company  shall not be  affected  by any notice to the
contrary.

     All terms used in this Warrant Certificate which are defined in the Warrant
Agreement shall have the meanings assigned to them in the Warrant Agreement.




<PAGE>



     IN WITNESS WHEREOF,  the Company has caused this Warrant  Certificate to be
duly executed under its corporate seal.


Dated:  December 28, 1995            ACCUMED INTERNATIONAL, INC.




[SEAL]                               By:___________________________
                                        Name:  Peter P. Gombrich
                                        Title: Chief Executive Officer




Attest:


______________________
Mark L. Santor
Secretary



            WARRANT   AGREEMENT   dated  as  of  May  9,  1995  between   Alamar
BioSciences,  Inc., a California  corporation (the "Company"),  and Commonwealth
Associates (hereinafter referred to as "Commonwealth").

                             W I T N E S S E T H:

            WHEREAS,  the Company  proposes to issue to Commonwealth  Associates
("Commonwealth")  warrants  ("Warrants")  to purchase up to 264,840  shares (the
"Shares") of common stock of the Company, no par value (the "Common Stock"); and

            WHEREAS,  the Warrants  issued  pursuant to this Agreement are being
issued by the Company to  Commonwealth  and/or its designees in connection  with
Commonwealth's  role as placement agent for a private placement of the Company's
Common Stock pursuant to the Company's  Confidential  Private Offshore  Offering
Memorandum dated April 19, 1995 and the Company's  Confidential Private Offering
Memorandum dated April 21, 1995;

            NOW,  THEREFORE,  in consideration  of the premises,  the payment by
Commonwealth  to the Company of ONE DOLLAR  ($1.00),  the agreements  herein set
forth and other good and valuable consideration,  the receipt and sufficiency of
which are hereby acknowledged, the parties hereto agree as follows:

            1.    Grant.

            Commonwealth,  and/or its designees, are hereby granted the right to
purchase, at any time from May 9, 1995 until 5:00 P.M. New York City time on May
9, 2000 (the "Warrant  Exercise Term"),  up to 264,840 (subject to adjustment as
provided in Article 8 hereof)  Shares at an initial  exercise  price (subject to
adjustment as provided in Article 8 hereof) of $0.625 per Share.

            2.    Warrant Certificates.

            The warrant certificates (the "Warrant Certificates")  delivered and
to be  delivered  pursuant to this  Agreement  shall be in the form set forth as
Exhibit  A,  attached  hereto  and made a part  hereof,  with  such  appropriate
insertions,  omissions,  substitutions  and  other  variations  as  required  or
permitted by this Agreement.

            3.    Exercise of Warrants.

                  3.1 Cash Exercise. The Warrants initially are exercisable at a
price of  $0.625  per  Share,  payable  in cash or by check to the  order of the
Company, or any combination of cash or check,  subject to adjustment as provided
in Article 8 hereof.  Upon surrender of the Warrant Certificate with the annexed
Form of  Election  to  Purchase  duly  executed,  together  with  payment of the
Exercise  Price  (as  hereinafter  defined)  for the  Shares  purchased,  at the
Company's  principal  offices  (presently  located  at  4110 N.  Freeway  Blvd.,
Sacramento,  CA 95834) the registered holder of a Warrant Certificate  ("Holder"
or "Holders") shall be entitled to receive a certificate or certificates for the
Shares


<PAGE>



so purchased.  The purchase rights  represented by each Warrant  Certificate are
exercisable at the option of the Holder thereof, in whole or in part (but not as
to fractional  shares of the Common Stock).  In the case of the purchase of less
than all the Shares purchasable under any Warrant Certificate, the Company shall
cancel said Warrant Certificate upon the surrender thereof and shall execute and
deliver a new  Warrant  Certificate  of like tenor for the balance of the Shares
purchasable thereunder.

                  3.2 Cashless Exercise. At any time during the Warrant Exercise
Term,  the Holder may, at its option,  exchange  all or part of the  Warrants (a
"Warrant  Exchange"),  into the number of Shares  determined in accordance  with
this Section  3.2, by  surrendering  his Warrant  Certificate  at the  principal
office of the Company or at the office of its transfer  agent,  accompanied by a
notice  stating  such  holder's  intent to effect such  exchange,  the number of
Shares to be  exchanged  and the date on which  the  Holder  requests  that such
Warrant  Exchange occur (the "Notice of Exchange").  The Warrant  Exchange shall
take place on the date  specified  in the Notice of Exchange  or, if later,  the
date the Notice of Exchange is received by the Company  (the  "Exchange  Date").
Certificates  for the  Shares  issuable  upon  such  Warrant  Exchange  and,  if
applicable,  a new warrant or warrants of like tenor  evidencing  the balance of
the Shares remaining subject to the Warrants, shall be issued as of the Exchange
Date and  delivered to the Holder  within seven (7) days  following the Exchange
Date.  In  connection  with  any  Warrant  Exchange,   the  Warrant  Certificate
surrendered shall represent the right to subscribe for and acquire the number of
Shares  (rounded to the next highest  integer) equal to (i) the number of Shares
specified by the Holder in its Notice of Exchange (the "Total Number") less (ii)
the number of Shares equal to the quotient  obtained by dividing (A) the product
of the Total Number and the existing Exercise Price (as hereinafter  defined) by
(B) the current market value of a share of Common Stock.

            4.    Issuance of Certificates.

            Upon the exercise of the Warrants,  the issuance of certificates for
the Shares shall be made  forthwith (and in any event within three business days
thereafter) without charge to the Holder thereof including,  without limitation,
any tax which may be  payable  in  respect  of the  issuance  thereof,  and such
certificates  shall (subject to the provisions of Article 5 hereof) be issued in
the name of,  or in such  names  as may be  directed  by,  the  Holder  thereof;
provided,  however,  that the Company shall not be required to pay any tax which
may be payable in respect of any transfer  involved in the issuance and delivery
of any such certificates in a name other than that of the Holder and the Company
shall not be required to issue or deliver such certificates  unless or until the
person or persons requesting the issuance thereof shall have paid to the Company
the  amount of such tax or shall have  established  to the  satisfaction  of the
Company that such tax has been paid.

                                    -2-


<PAGE>




            The  Warrant  Certificates  and the  certificates  representing  the
Shares  shall be executed  on behalf of the  Company by the manual or  facsimile
signature of the present or any future Chairman or Vice Chairman of the Board of
Directors or Chief Executive Officer, President or Vice President of the Company
under its  corporate  seal  reproduced  thereon,  attested  to by the  manual or
facsimile  signature  of  the  present  or any  future  Secretary  or  Assistant
Secretary  of the  Company.  Warrant  Certificates  shall be  dated  the date of
execution by the Company upon initial issuance, division, exchange, substitution
or transfer.

            The Warrant Certificates and, upon exercise of the Warrants, in part
or  in  whole,   certificates  representing  the  Shares  shall  bear  a  legend
substantially similar to the following:

      "The securities  represented by this  certificate have not been registered
      under the Securities  Act of 1933, as amended (the "Act"),  and may not be
      offered or sold except (i) pursuant to an effective registration statement
      under the Act, (ii) to the extent  applicable,  pursuant to Rule 144 under
      the Act (or any similar rule under such Act relating to the disposition of
      securities), or (iii) upon the delivery by the holder to the Company of an
      opinion of counsel,  reasonably  satisfactory  to counsel to the  Company,
      stating that an exemption from registration under such Act is available."

            5.    Investment Restriction.

            The  Holder of a Warrant  Certificate,  by its  acceptance  thereof,
covenants and agrees that the Warrants are being  acquired as an investment  and
not with a view to the distribution thereof.

            6.    Price.

                  6.1 Initial and Adjusted  Exercise Price. The initial exercise
prices of each Warrant shall be $0.625 per Share.  The adjusted  exercise  price
shall  be the  price  which  shall  result  from  time to time  from any and all
adjustments of the initial  exercise price in accordance  with the provisions of
Article 8 hereof.

                  6.2 Exercise  Price.  The term  "Exercise  Price" herein shall
mean the initial exercise price or the adjusted  exercise price,  depending upon
the context.

            7.    Registration Rights.

                  7.1  Registration  Under  the  Securities  Act  of  1933.  The
Warrants and the Shares have not been registered for

                                    -3-


<PAGE>



purposes of public  distribution  under the  Securities  Act of 1933, as amended
("the Act").

                  7.2   Registrable   Securities.   As  used   herein  the  term
"Registrable  Security" means each of the Warrants, the Shares and any shares of
Common  Stock  issued upon any stock split or stock  dividend in respect of such
Shares;  provided,  however,  that with  respect to any  particular  Registrable
Security, such security shall cease to be a Registrable Security when, as of the
date  of  determination,  (i) it  has  been  effectively  registered  under  the
Securities Act and disposed of pursuant  thereto,  (ii)  registration  under the
Securities Act is no longer  required for the immediate  public  distribution of
such security or (iii) it has ceased to be  outstanding.  The term  "Registrable
Securities" means any and/or all of the securities  falling within the foregoing
definition   of  a   "Registrable   Security."  In  the  event  of  any  merger,
reorganization,  consolidation,  recapitalization  or other  change in corporate
structure  affecting  the Common  Stock,  such  adjustment  shall be made in the
definition of  "Registrable  Security" as is appropriate in order to prevent any
dilution or enlargement of the rights granted pursuant to this Article 7.

                  7.3 Piggyback  Registration.  If, at any time during the seven
years following the date of this Agreement,  the Company proposes to prepare and
file any registration  statement or post-effective  amendments  thereto covering
equity or debt securities of the Company,  or any such securities of the Company
held by its  shareholders  (in any such case,  other than in  connection  with a
merger, acquisition or pursuant to Form S-8 or successor form), (for purposes of
this Article 7, collectively,  a "Registration Statement"), it will give written
notice of its intention to do so by registered mail ("Notice"),  at least thirty
(30) business days prior to the filing of each such Registration  Statement,  to
all holders of the  Registrable  Securities.  Upon the written request of such a
holder (a  "Requesting  Holder"),  made within  twenty (20)  business days after
receipt of the Notice,  that the Company include any of the Requesting  Holder's
Registrable  Securities  in the  proposed  Registration  Statement,  the Company
shall,  as to each such  Requesting  Holder,  use its best efforts to effect the
registration under the Securities Act of the Registrable Securities which it has
been so requested to register ("Piggyback Registration"),  at the Company's sole
cost and expense and at no cost or expense to the Requesting Holders.

            7.4   Demand Registration.

                       (a) At any time during the  Warrant  Exercise  Term,  any
"Majority  Holder"  (as such term is  defined in  Section  7.4(d)  below) of the
Registrable  Securities  shall have the right (which right is in addition to the
piggyback   registration   rights   provided  for  under  Section  7.3  hereof),
exercisable  by  written  notice  to  the  Company  (the  "Demand   Registration
Request"), to have the Company prepare and file with the Securities and Exchange
Commission (the "Commission"), on one occasion, at the

                                    -4-


<PAGE>



sole  expense of the Company  (other than the pro rata  portion of  underwriting
discounts,  if any, attributable to the Holder's Registrable  Securities and the
expenses of Holder's  counsel and advisors),  a Registration  Statement and such
other documents,  including a prospectus, as may be necessary (in the opinion of
both counsel for the Company and counsel for such Majority Holder),  in order to
comply with the  provisions  of the Act, so as to permit a public  offering  and
sale of the  Registrable  Securities  until  such  time  as (i) the  sale of all
Registrable  Securities  by the holders  thereof or (ii)  receipt by the holders
thereof of an opinion of Company's  counsel that the Registrable  Securities may
be immediately publicly sold without registration under the Securities Act.

                       (b) The  Company  covenants  and  agrees to give  written
notice of any  Demand  Registration  Request to all  holders of the  Registrable
Securities  within ten (10) days from the date of the  Company's  receipt of any
such Demand  Registration  Request.  After receiving  notice from the Company as
provided in this Section 7.4(b),  holders of Registrable  Securities may request
the  Company  to  include  their  Registrable  Securities  in  the  Registration
Statement to be filed pursuant to Section 7.4(a) hereof by notifying the Company
of their  decision  to  include  such  securities  within ten (10) days of their
receipt of the Company's notice.

                       (c) The term  "Majority  Holder" as used in this  Section
7.4  shall  mean  any  holder  or any  combination  of  holders  of  Registrable
Securities,  if  included  in such  holders'  Registrable  Securities  are  that
aggregate number of Shares  (including Shares already issued and Shares issuable
pursuant to the exercise of outstanding Warrants) as would constitute a majority
of the aggregate  number of Shares  (including  Shares already issued and Shares
issuable  pursuant to the exercise of outstanding  Warrants)  included in all of
the Registrable Securities.

            7.5   Covenants  of the Company  With  Respect to  Registration. The
Company covenants and agrees as follows:

                       (a) In connection with any registration under Section 7.4
hereof,  the Company shall file the  Registration  Statement as expeditiously as
possible, but in no event later than twenty (20) business days following receipt
of any demand therefor, shall use its best efforts to have any such Registration
Statements  declared  effective at the earliest possible time, and shall furnish
each  holder of  Registrable  Securities  such number of  prospectuses  as shall
reasonably  be  requested.  In connection  with the  obligations  of the Company
hereunder  to  register  a Holder's  Registrable  Securities,  the Holder  shall
furnish  the Company  such  information  concerning  the  Holder,  the  Holder's
Registrable  Securities  and the  terms  of the  offering  of  such  Registrable
Securities by the Holder as the Company may

                                    -5-


<PAGE>



reasonably request in order to comply with the provisions of the Act with resect
to the Registration Statement to be filed.

                       (b) Other than fees and  disbursements  of counsel acting
on behalf of the holders of  Registrable  Securities and the pro rata portion of
the underwriting discounts and commissions,  if any, attributable to Registrable
Securities,  the Company  shall pay all costs,  fees and expenses in  connection
with all  Registration  Statements  filed  pursuant to  Sections  7.3 and 7.4(a)
hereof including,  without limitation,  the Company's legal and accounting fees,
printing expenses, and blue sky fees and expenses.

                       (c) The Company will take all necessary  action which may
be required in qualifying or registering the Registrable  Securities included in
a Registration  Statement for offering and sale under the securities or blue sky
laws of such states as are requested by the holders of such securities, provided
that the Company  shall not be obligated to execute or file any general  consent
to service of process  or to  qualify as a foreign  corporation  to do  business
under the laws of any such jurisdiction.

                       (d)  The  Company  shall  indemnify  any  holder  of  the
Registrable Securities to be sold pursuant to any Registration Statement and any
underwriter or person deemed to be an underwriter under the Act and each person,
if any,  who  controls  such  holder or  underwriter  or person  deemed to be an
underwriter  within the meaning of Section 15 of the Act or Section 20(a) of the
Securities  Exchange Act of 1934, as amended  ("Exchange Act"), from and against
any and all losses,  claims,  damages,  expenses and liabilities  (including all
expenses  reasonably  incurred in investigating,  preparing or defending against
any  claim  whatsoever)  caused  by any  untrue  statement  of a  material  fact
contained in the Registration Statement,  any other registration statement filed
by the Company under the Act, any post-effective  amendment to such registration
statements, or any prospectus included therein required to be filed or furnished
by reason of this  Agreement  or caused by any  omission or alleged  omission to
state therein a material fact required to be stated therein or necessary to make
the statements  therein not misleading,  except insofar as such losses,  claims,
damages,  expenses or  liabilities  are caused by any such untrue  statement  or
alleged untrue  statement or omission or alleged omission based upon information
furnished or required to be furnished in writing to the company by the Holder or
underwriter expressly for use therein;  which indemnification shall include each
person,  if any, who controls any such Holder or underwriter  within the meaning
of the Act and each  officer,  director,  employee  and agent of such  Holder or
underwriter;  provided,  however,  that the Company shall not be obligated to so
indemnify the Holder or any such  underwriter or other person  referred to above
unless the Holder or underwriter  or other person,  as the case may be, shall at
the same time indemnify the Company, its directors, each officer signing the

                                    -6-


<PAGE>



registration  statement and each person, if any, who controls the Company within
the meaning of the Act,  from and against any and all losses,  claims,  damages,
expenses  and  liabilities  caused by any untrue  statement  or  alleged  untrue
statement  of a material  fact  contained  in the  registration  Statement,  any
registration  statement or any  prospectus  required to be filed or furnished by
reason of this  Agreement or caused by any omission to state  therein a material
fact required to be stated therein or necessary to make the  statements  therein
not misleading, insofar as such losses, claims, damages, expenses or liabilities
are caused by any untrue statement or alleged untrue statement or omission based
upon  information  furnished  in  writing  to  the  Company  by  the  Holder  or
underwriter  expressly for use therein,  and provided,  further that the holder,
each person,  if any, who controls the holder within the meaning of the Act, and
each of the  Holder's  directors,  officers,  employees  and agents shall not be
obligated  to  indemnify  any  indemnified  person  pursuant  to  the  foregoing
indemnity, or to make any contribution pursuant to subparagraph 7.5(f) below, in
an amount in excess of the net proceeds  received by such holder with respect to
the sale of Registrable Securities.

                       (e) Promptly after receipt of notice of the  commencement
of any  action  in  respect  of  which  indemnity  may  be  sought  against  any
indemnifying party under this Section 7.5, the indemnified party will notify the
indemnifying party in writing of the commencement  thereof, and the indemnifying
party will, subject to the provisions  hereinafter stated, assume the defense of
such action  (including  the  employment  of counsel  reasonably  subject to the
provisions  hereinafter stated, assume the defense of such action (including the
employment of counsel  reasonably  satisfactory to the indemnified party and the
payment of expenses)  insofar as such action relates to an alleged  liability in
respect of which indemnity may be sought against the indemnifying  party.  After
notice from the indemnifying party of its election to assume the defense of such
claim or  action,  the  indemnifying  party  shall no  longer  by  liable to the
indemnified  party  under  this  Section  7.5 for any  legal or  other  expenses
subsequently  incurred by the  indemnified  party in connection with the defense
thereof other than reasonable costs of investigation;  provided,  however,  that
if, in the written opinion of counsel to the indemnified party or parties, it is
advisable  for  the  indemnified  party  or  parties,  it is  advisable  for the
indemnified  party  or  parties  to be  represented  by  separate  counsel,  the
indemnified  party or parties shall have the right to employ a single counsel to
represent the indemnified parties who may be subject to liability arising out of
any claim in respect of which indemnity may be sought by the indemnified parties
thereof against the  indemnifying  party, in which event the reasonable fees and
expenses of such separate counsel shall be borne by the indemnifying  party. Any
party  against whom  indemnification  may be sought under this Section 7.5 shall
not be liable to  indemnify  any person  that  might  otherwise  be  indemnified
pursuant hereto for any settlement of any action effected without such

                                    -7-


<PAGE>



indemnifying party's consent, which consent shall not be unreasonably withheld.

                       (f) If for any reason the indemnification provided for in
this Section 7.5 is held by a court of competent  jurisdiction to be unavailable
to an  indemnified  party with respect to any loss,  claim,  damage,  expense or
liability  referred  to  therein,  then  the  indemnifying  party,  in  lieu  of
indemnifying such indemnified  party thereunder,  shall contribute to the amount
paid or  payable  by the  indemnified  party as a result  of such  loss,  claim,
damage, expense or liability in such proportion as is appropriate to reflect not
only  the  relative   benefits   received  by  the  indemnified  party  and  the
indemnifying party, but also the relative fault of the indemnified party and the
indemnifying party, as well as any other relevant equitable considerations.

                       (g)  Nothing   contained  in  this  Agreement   shall  be
construed as requiring any Holder to exercise his Warrants  prior to the initial
filing of any Registration Statement or the effectiveness thereof.

            8.    Adjustments of Exercise Price and Number of Shares.

                  8.1  Computation  of  Adjusted  Price.  Except as  hereinafter
provided,  in case the Company  shall at any time after the date hereof issue or
sell any shares of Common Stock (other than the  issuances or sales  referred to
in Section 8.6  hereof),  including  shares held in the  Company's  treasury and
shares of Common  Stock  issued  upon the  exercise  of any  options,  rights or
warrants to subscribe  for shares of Common  Stock (other than the  issuances or
sales of Common  Stock  pursuant to rights to  subscribe  for such Common  Stock
distributed  to all the  shareholders  of the  Company  and  Holders of Warrants
pursuant  to Section  8.8  hereof)  and shares of Common  Stock  issued upon the
direct or indirect  conversion  or exchange of  securities  for shares of Common
Stock,  for a  consideration  per share less than either the  Exercise  Price in
effect  immediately  prior to the issuance or sale of such shares or the "Market
Price" (as  defined  in Section  8.1(vi)  hereof)  per share of Common  Stock or
without  consideration,  then forthwith upon such issuance or sale, the Exercise
Price shall  (until  another  such  issuance  or sale),  be reduced to the price
(calculated to the nearest full cent) equal to the quotient  derived by dividing
(A) an amount  equal to the sum of (X) the  product  of (a) the total  number of
shares of Common Stock  outstanding  immediately prior to such issuance or sale,
multiplied  by (b) the lower of (i) the  Exercise  Price in  effect  immediately
prior to such  issuance  or sale or (ii)  the  "Market  Price"  (as  defined  in
subsection  (vi) of this  Section 8.1  hereof) per share of Common  Stock on the
date  immediately  prior to the issuance or sale of such shares,  plus,  (Y) the
aggregate of the amount of all  consideration,  if any,  received by the Company
upon such  issuance or sale,  by (B) the total  number of shares of Common Stock
outstanding immediately after such issuance or sale; provided,  however, that in
no event shall the

                                    -8-


<PAGE>



Exercise Price be adjusted  pursuant to this  computation to an amount in excess
of the Exercise Price in effect immediately prior to such computation, except in
the case of a combination of outstanding  shares of Common Stock, as provided by
Section 8.3 hereof.

            For the purposes of any  computation  to be made in accordance  with
this Section 8.1, the following provisions shall be applicable:

                       (i) In case of the  issuance  or sale of shares of Common
Stock for a consideration  part or all of which shall be cash, the amount of the
cash consideration therefor shall be deemed to be the amount of cash received by
the Company  for such  shares (or, if shares of Common  Stock are offered by the
Company for subscription,  the subscription  price, or, if such securities shall
be sold to underwriters  or dealers for public  offering  without a subscription
offering,  the initial public  offering  price) before  deducting  therefrom any
compensation  paid or  discount  allowed in the sale,  underwriting  or purchase
thereof by underwriters or dealers or others performing similar services, or any
expenses incurred in connection therewith.

                       (ii) In case of the issuance or sale (otherwise than as a
dividend or other  distribution on any stock of the Company) of shares of Common
Stock for a  consideration  part or all of which  shall be other than cash,  the
amount of the  consideration  therefor other than cash shall be deemed to be the
value  of such  consideration  as  determined  in good  faith  by the  Board  of
Directors of the Company.

                       (iii) Shares of Common Stock  issuable by way of dividend
or other  distribution  on any stock of the Company shall be deemed to have been
issued immediately after the opening of business on the day following the record
date for the determination of shareholders  entitled to receive such dividend or
other   distribution   and  shall  be  deemed  to  have  been   issued   without
consideration.

                       (iv) The  reclassification  of  securities of the Company
other than shares of Common  Stock into  securities  including  shares of Common
Stock shall be deemed to involve the issuance of such shares of Common Stock for
a consideration  other than cash  immediately  prior to the close of business on
the date fixed for the  determination  of security  holders  entitled to receive
such  shares,  and the value of the  consideration  allocable  to such shares of
Common Stock shall be determined as provided in subsection  (ii) of this Section
8.1.

                       (v) The number of shares of Common  Stock at any one time
outstanding shall include the aggregate number of shares issued or issuable upon
the exercise of options, rights, warrants and upon the conversion or exchange of
convertible or exchangeable securities.


                                    -9-


<PAGE>



                       (vi) As used  herein,  the phrase  "Market  Price" at any
date shall be deemed to be the last  reported  sale  price,  or, in case no such
reported  sale takes place on such day,  the average of the last  reported  sale
prices for the last three trading days, in either case as officially reported by
the  principal  securities  exchange  on which  the  Common  Stock is  listed or
admitted to trading or as reported in the NASDAQ National Market System,  or, if
the Common Stock is not listed or admitted to trading on any national securities
exchange or quoted on the NASDAQ National  Market System,  the closing bid price
as furnished by the National  Association of Securities  Dealers,  Inc.  through
NASDAQ  or  similar   organization  if  NASDAQ  is  no  longer   reporting  such
information,  or if the Common Stock is not quoted on NASDAQ,  as  determined in
good faith by resolution of the Board of Directors of the Company,  based on the
best  information  available to it for the two days  immediately  preceding such
issuance or sale and the day of such issuance or sale.

                  8.2 Options, Rights, Warrants and Convertible and Exchangeable
Securities.  Except in the case of the Company  issuing  rights to subscribe for
shares of Common Stock  distributed to all the  shareholders  of the Company and
Holders of Warrants  pursuant to Section 8.8 hereof, if the Company shall at any
time after the date hereof issue  options,  rights or warrants to subscribe  for
shares of Common Stock, or issue any securities convertible into or exchangeable
for shares of Common Stock, (i) for a consideration  per share less than (a) the
Exercise  Price in effect  immediately  prior to the  issuance of such  options,
rights or warrants, or such convertible or exchangeable  securities,  or (b) the
Market  Price,  or (ii)  without  consideration,  the  Exercise  Price in effect
immediately prior to the issuance of such options,  rights or warrants,  or such
convertible or exchangeable securities,  as the case may be, shall be reduced to
a price  determined by making a computation in accordance with the provisions of
Section 8.1 hereof, provided that:

                       (a) The  aggregate  maximum  number  of  shares of Common
Stock, as the case may be, issuable under all the outstanding options, rights or
warrants  shall be  deemed  to be  issued  and  outstanding  at the time all the
outstanding  options,  rights or warrants were issued,  and for a  consideration
equal to the  minimum  purchase  price per share  provided  for in the  options,
rights or warrants at the time of issuance,  plus the consideration  (determined
in the same manner as  consideration  received on the issue or sale of shares in
accordance with the terms of the Warrants),  if any, received by the Company for
the  options,  rights or  warrants,  and if no minimum  price is provided in the
options,  rights or  warrants,  then the  consideration  shall be equal to zero;
provided, however, that upon the expiration or other termination of the options,
rights or warrants, if any thereof shall not have been exercised,  the number of
shares of Common  Stock  deemed to be issued and  outstanding  pursuant  to this
subsection  (a) (and for the purposes of  subsection  (v) of Section 8.1 hereof)
shall be reduced by such number of shares as to which

                                    -10-


<PAGE>



options,  warrants  and/or rights shall have expired or terminated  unexercised,
and  such  number  of  shares  shall  no  longer  be  deemed  to be  issued  and
outstanding, and the Exercise Price then in effect shall forthwith be readjusted
and thereafter be the price which it would have been had adjustment been made on
the basis of the issuance  only of shares  actually  issued or issuable upon the
exercise of those  options,  rights or warrants as to which the exercise  rights
shall not have expired or terminated unexercised.

                       (b) The  aggregate  maximum  number  of  shares of Common
Stock issuable upon  conversion or exchange of any  convertible or  exchangeable
securities  shall be deemed to be issued and outstanding at the time of issuance
of  such  securities,  and  for  a  consideration  equal  to  the  consideration
(determined in the same manner as consideration received on the issue or sale of
shares of Common Stock in accordance with the terms of the Warrants) received by
the  Company  for such  securities,  plus  the  minimum  consideration,  if any,
receivable  by the Company upon the  conversion or exchange  thereof;  provided,
however,  that upon the  termination  of the right to convert or  exchange  such
convertible  or  exchangeable  securities  (whether by reason of  redemption  or
otherwise), the number of shares deemed to be issued and outstanding pursuant to
this  subsection  (b) (and for the  purpose of  subsection  (v) of  Section  8.1
hereof) shall be reduced by such number of shares as to which the  conversion or
exchange rights shall have expired or terminated unexercised, and such number of
shares shall no longer be deemed to be issued and  outstanding  and the Exercise
Price then in effect shall  forthwith be readjusted  and thereafter be the price
which it would have been had  adjustment  been made on the basis of the issuance
only of the shares  actually  issued or issuable upon the conversion or exchange
of those  convertible or  exchangeable  securities as to which the conversion or
exchange rights shall not have expired or terminated unexercised.

                       (c) If any  change  shall  occur in the  price  per share
provided for in any of the options, rights or warrants referred to in subsection
(a) of this  Section  8.2,  or in the price  per  share at which the  securities
referred  to  in  subsection  (b)  of  this  Section  8.2  are   convertible  or
exchangeable,  the options, rights or warrants or conversion or exchange rights,
as the case may be,  shall be deemed to have expired or  terminated  on the date
when such price change  became  effective  in respect of shares not  theretofore
issued  pursuant to the  exercise or  conversion  or exchange  thereof,  and the
Company  shall be deemed to have  issued upon such date new  options,  rights or
warrants or convertible or  exchangeable  securities at the new price in respect
of the number of shares  issuable upon the exercise of such  options,  rights or
warrants  or the  conversion  or exchange of such  convertible  or  exchangeable
securities.

                  8.3 Subdivision and Combination.  In case the Company shall at
any time  subdivide  or combine  the  outstanding  shares of Common  Stock,  the
Exercise Price shall forthwith be

                                    -11-


<PAGE>



proportionately decreased in the case of subdivision or increased in the case of
combination.

                  8.4  Adjustment in Number of Shares.  Upon each  adjustment of
the Exercise  Price  pursuant to the provisions of this Article 8, the number of
Shares  issuable  upon the  exercise  of each  Warrant  shall be adjusted to the
nearest full Share by multiplying a number equal to the Exercise Price in effect
immediately  prior to such  adjustment  by the  number of Shares  issuable  upon
exercise of the Warrants  immediately  prior to such adjustment and dividing the
product so obtained by the adjusted Exercise Price.

                  8.5 Reclassification,  Consolidation,  Merger, etc. In case of
any  reclassification or change of the outstanding shares of Common Stock (other
than a change in par value to no par  value,  or from no par value to par value,
or as a  result  of a  subdivision  or  combination),  or in  the  case  of  any
consolidation  of the  Company  with,  or merger of the  Company  into,  another
corporation  (other than a  consolidation  or merger in which the Company is the
surviving  corporation  and which  does not  result in any  reclassification  or
change of the outstanding shares of Common Stock, except a change as a result of
a  subdivision  or  combination  of such  shares  or a change in par  value,  as
aforesaid), or in the case of a sale or conveyance to another corporation of the
property of the Company as an entirety,  the Holders shall  thereafter  have the
right to  purchase  the kind and number of shares of stock and other  securities
and  property  receivable  upon such  reclassification,  change,  consolidation,
merger,  sale or  conveyance  as if the Holders were the owners of the shares of
Common Stock underlying the Warrants  immediately  prior to any such events at a
price equal to the product of (x) the number of shares issuable upon exercise of
the  Warrants  and (y) the  Exercise  Price in effect  immediately  prior to the
record date for such reclassification,  change,  consolidation,  merger, sale or
conveyance as if such Holders had exercised the Warrants.

                  8.6 No  Adjustment  of  Exercise  Price in Certain  Cases.  No
adjustment of the Exercise Price shall be made:

                        (a) Upon the  issuance or sale of shares of Common Stock
            upon the exercise of the Warrants;

                        (b) Upon (i) the issuance of options  pursuant to any of
            the  Company's  employee  stock  option  plans in effect on the date
            hereof or any  employee  stock  option plan  adopted  after the date
            hereof by  stockholders  of the Company the  issuance or sale by the
            Company of any shares of Common  Stock  pursuant to the  exercise of
            any such options, or (ii) the issuance or sale by the Company of any
            shares of Common  Stock  pursuant to the  exercise of any options or
            warrants previously issued and outstanding on the date hereof;


                                    -12-


<PAGE>



                        (c) Upon  issuance of any shares of Common Stock sold in
            the Company's offerings of an aggregate of up to 4,000,000 shares of
            Common  Stock being  conducted  pursuant to the  Company's  Offering
            Memoranda dated April 19, 1995 and April 21, 1995, respectively; or

                        (d) Upon the  issuance of any shares of Common  Stock in
            connection with the Company's merger with AccuMed, Inc.

                  8.7  Dividends  and  Other   Distributions   with  Respect  to
Outstanding Securities. In the event that the Company shall at any time prior to
the  exercise  of all  Warrants  declare  a  dividend  (other  than  a  dividend
consisting  solely of shares of Common Stock or a cash dividend or  distribution
payable out of current or retained  earnings)  or  otherwise  distribute  to its
shareholders any monies, assets,  property,  rights,  evidences of indebtedness,
securities (other than shares of Common Stock), whether issued by the Company or
by another person or entity,  or any other thing of value, the Holder or Holders
of the  unexercised  Warrants shall  thereafter be entitled,  in addition to the
shares of Common Stock or other securities receivable upon the exercise thereof,
to receive,  upon the  exercise of such  Warrants,  the same  monies,  property,
assets,  rights,  evidences of  indebtedness,  securities  or any other thing of
value that they would have been entitled to receive at the time of such dividend
or distribution.  At the time of any such dividend or distribution,  the Company
shall  make  appropriate  reserves  to  ensure  the  timely  performance  of the
provisions of this Subsection 8.7.

                  8.8  Subscription  Rights for Shares of Common  Stock or Other
Securities.  In the case the Company or an affiliate of the Company shall at any
time after the date hereof and prior to the exercise of all the  Warrants  issue
any rights to subscribe  for shares of Common Stock or any other  securities  of
the Company or of such  affiliate to all the  shareholders  of the Company,  the
Holders of the unexercised Warrants shall be entitled, in addition to the shares
of  Common  Stock or  other  securities  receivable  upon  the  exercise  of the
Warrants,  to receive such rights at the time such rights are distributed to the
other shareholders of the Company.

            9. Exchange and Replacement of Warrant Certificates.

            Each Warrant Certificate is exchangeable  without expense,  upon the
surrender hereof by the registered  Holder at the principal  executive office of
the Company,  for a new Warrant  Certificate of like tenor and date representing
in the  aggregate  the  right to  purchase  the same  number  of  Shares in such
denominations  as shall be designated by the Holder  thereof at the time of such
surrender.


                                    -13-


<PAGE>



            Upon receipt by the Company of evidence  reasonably  satisfactory to
it of the loss,  theft,  destruction  or mutilation of any Warrant  Certificate,
and, in case of loss, theft or destruction,  of indemnity or security reasonably
satisfactory to it, and reimbursement to the Company of all reasonable  expenses
incidental  thereto,  and upon surrender and  cancellation  of the Warrants,  if
mutilated,  the Company will make and deliver a new Warrant  Certificate of like
tenor, in lieu thereof.

            10.   Elimination of Fractional Interests.

            The Company shall not be required to issue certificates representing
fractions  of shares of Common Stock and shall not be required to issue scrip or
pay cash in lieu of  fractional  interests,  it being the intent of the  parties
that all fractional interests shall be eliminated by rounding any fraction up to
the nearest whole number of shares of Common Stock.

            11. Reservation and Listing of Securities.

            The Company shall at all times reserve and keep available out of its
authorized  shares of Common Stock,  solely for the purpose of issuance upon the
exercise  of the  Warrants,  such  number of shares of Common  Stock as shall be
issuable upon the exercise thereof.  The Company covenants and agrees that, upon
exercise of the Warrants and payment of the Exercise Price therefor,  all shares
of Common Stock  issuable upon such exercise  shall be duly and validly  issued,
fully  paid,  non-assessable  and not  subject to the  preemptive  rights of any
shareholder. As long as the Warrants shall be outstanding, the Company shall use
its best efforts to cause all shares of Common Stock  issuable upon the exercise
of the  Warrants to be listed on or quoted by NASDAQ or listed on such  national
securities exchanges as requested by Commonwealth.

            12.   Notices to Warrant Holders.

            Nothing contained in this Agreement shall be construed as conferring
upon the Holder or Holders the right to vote or to consent or to receive  notice
as a shareholder in respect of any meetings of shareholders  for the election of
directors  or  any  other  matter,  or as  having  any  rights  whatsoever  as a
shareholder of the Company.  If, however, at any time prior to the expiration of
the Warrants and their exercise, any of the following events shall occur:

                        (a) the  Company  shall take a record of the  holders of
            its  shares of Common  Stock for the  purpose of  entitling  them to
            receive a dividend or distribution  payable  otherwise than in cash,
            or a cash dividend or  distribution  payable  otherwise  than out of
            current  or  retained  earnings,  as  indicated  by  the  accounting
            treatment  of such  dividend  or  distribution  on the  books of the
            Company; or

                                    -14-


<PAGE>




                        (b) the  Company  shall  offer to all the holders of its
            Common Stock any  additional  shares of capital stock of the Company
            or securities convertible into or exchangeable for shares of capital
            stock of the Company,  or any option,  right or warrant to subscribe
            therefor; or

                        (c) a  dissolution,  liquidation  or  winding  up of the
            Company (other than in connection with a consolidation or merger) or
            a sale  of all or  substantially  all of its  property,  assets  and
            business as an entirety shall be proposed;

then, in any one or more of said events,  the Company shall give written  notice
of such  event at least  fifteen  (15) days  prior to the date fixed as a record
date or the date of closing  the  transfer  books for the  determination  of the
shareholders   entitled  to  such   dividend,   distribution,   convertible   or
exchangeable securities or subscription rights, options or warrants, or entitled
to vote on such  proposed  dissolution,  liquidation,  winding up or sale.  Such
notice shall specify such record date or the date of closing the transfer books,
as the case may be.  Failure to give such notice or any defect therein shall not
affect the validity of any action taken in connection  with the  declaration  or
payment of any such dividend or distribution, or the issuance of any convertible
or exchangeable  securities or subscription rights,  options or warrants, or any
proposed dissolution, liquidation, winding up or sale.

            13.   Notices.

            All notices,  requests,  consents and other communications hereunder
shall be in writing  and shall be deemed to have been duly made when  delivered,
or mailed by registered or certified mail, return receipt requested:

            (a) If to a  registered  Holder of the  Warrants,  to the address of
such Holder as shown on the books of the Company; or

            (b) If to the Company, to the address set forth in Section 3 of this
Agreement or to such other address as the Company may designate by notice to the
Holders.

            14.   Supplements and Amendments.

            The Company and  Commonwealth  may from time to time  supplement  or
amend this Agreement without the approval of any Holders of Warrant Certificates
in order to cure any ambiguity, to correct or supplement any provision contained
herein which may be defective or inconsistent with any provisions  herein, or to
make any other  provisions in regard to matters or questions  arising  hereunder
which the Company and Commonwealth may deem necessary or desirable and which the
Company and Commonwealth

                                    -15-


<PAGE>



deem  not  to  adversely   affect  the  interests  of  the  Holders  of  Warrant
Certificates.


            15.   Successors.

            All the  covenants and  provisions  of this  Agreement by or for the
benefit of the Company and the Holders inure to the benefit of their  respective
successors and assigns hereunder.

            16.   Termination.

            This  Agreement  shall  terminate at the close of business on May 9,
2003.  Notwithstanding  the  foregoing,  this  Agreement  will  terminate on any
earlier date when all Warrants have been  exercised and all the Shares  issuable
upon exercise of the Warrants have been resold to the public; provided, however,
that the  provisions  of Section 7.5 shall  survive such  termination  until the
close of business on May 9, 2006.

            17.   Governing Law.

            This Agreement and each Warrant  Certificate  issued hereunder shall
be deemed to be a contract  made under the laws of the State of New York and for
all purposes shall be construed in accordance with the laws of said State.

            18.   Benefits of This Agreement.

            Nothing in this  Agreement  shall be construed to give to any person
or corporation  other than the Company and Commonwealth and any other registered
holder or holders of the Warrant Certificates,  Warrants or the Shares any legal
or equitable  right,  remedy or claim under this  Agreement;  and this Agreement
shall be for the sole and exclusive  benefit of the Company and Commonwealth and
any other holder or holders of the Warrant Certificates, Warrants or the Shares.


                                    -16-


<PAGE>



            19.   Counterparts.

            This  Agreement  may be executed in any number of  counterparts  and
each of such  counterparts  shall for all  purposes be deemed to be an original,
and such counterparts shall together constitute but one and the same instrument.

            IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be duly executed, as of the day and year first above written.


[SEAL]                        ALAMAR BIOSCIENCES, INC.


                              By: /s/ Kenneth D. Miller          
                                 --------------------------------------
                                      Name:  Kenneth D. Miller
                                      Title: Chief Executive Officer
Attest:

/s/ M. Sauter
- --------------------------------------


                              COMMONWEALTH ASSOCIATES
                              By: Commonwealth Associates
                                  Management Company, Inc.,
                                  General Partner


                              By: /s/ [ILLEGIBLE TEXT}
                                 --------------------------------------
                                      Name:
                                      Title:

                                    -17-


<PAGE>





THE WARRANTS  REPRESENTED BY THIS CERTIFICATE AND THE OTHER SECURITIES  ISSUABLE
UPON EXERCISE THEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED (THE "ACT"), AND MAY NOT BE OFFERED OR SOLD EXCEPT (i) PURSUANT TO AN
EFFECTIVE  REGISTRATION  STATEMENT UNDER THE ACT, (ii) TO THE EXTENT APPLICABLE,
PURSUANT TO RULE 144 UNDER SUCH ACT (OR ANY SIMILAR RULE UNDER SUCH ACT RELATING
TO THE DISPOSITION OF  SECURITIES),  OR (iii) UPON THE DELIVERY BY THE HOLDER TO
THE COMPANY OF AN OPINION OF COUNSEL, REASONABLY SATISFACTORY TO COUNSEL FOR THE
COMPANY,  STATING  THAT  AN  EXEMPTION  FROM  REGISTRATION  UNDER  SUCH  ACT  IS
AVAILABLE.

THE TRANSFER OR EXCHANGE OF THE WARRANTS REPRESENTED BY THIS
CERTIFICATE IS RESTRICTED IN ACCORDANCE WITH THE WARRANT AGREE-
MENT REFERRED TO HEREIN.

                           EXERCISABLE ON OR BEFORE
                  5:00 P.M., NEW YORK CITY TIME,  May 9, 2000

No. W-1                                                  264,840 Warrants

                              WARRANT CERTIFICATE

            This Warrant  Certificate  certifies  that  Commonwealth  Associates
("Commonwealth")  or registered  assigns,  is the  registered  holder of 264,840
Warrants to purchase, at any time from May 9, 1995 until 5:00 P.M. New York City
time on May 9, 2000 (the "Expiration  Date") up to 264,840 shares  ("Shares") of
fully-paid and  non-assessable  common stock, no par value ("Common Stock"),  of
Alamar  BioSciences,  Inc., a California  corporation  (the  "Company"),  at the
initial  exercise price,  subject to adjustment in certain events (the "Exercise
Price"),  of $0.625 per Share,  upon surrender of this Warrant  Certificate  and
payment of the Exercise Price at an office or agency of the Company, but subject
to the conditions set forth herein and in the warrant  agreement dated as of May
9, 1995 between the Company and Commonwealth (the "Warrant Agreement").  Payment
of the Exercise  Price may be made in cash,  or by check payable to the order of
the Company, or any combination of cash or check.

            No Warrant may be exercised  after 5:00 P.M., New York City time, on
the  Expiration  Date,  at which  time all  Warrants  evidenced  hereby,  unless
exercised prior thereto, shall thereafter be void.

            The Warrants  evidenced by this  Warrant  Certificate  are part of a
duly  authorized  issue of Warrants  issued  pursuant to the Warrant  Agreement,
which Warrant  Agreement is hereby  incorporated by reference in and made a part
of this  instrument  and is hereby  referred to in a description  of the rights,
limitation  of rights,  obligations,  duties and  immunities  thereunder  of the
Company and the holders (the words "holders" or "holder"  meaning the registered
holders or registered holder) of the Warrants.



<PAGE>



            The Warrant  Agreement  provides that upon the occurrence of certain
events,  the Exercise Price and/or number of the Company's  securities  issuable
thereupon may, subject to certain  conditions,  be adjusted.  In such event, the
Company  will,  at the  request of the holder,  issue a new Warrant  Certificate
evidencing  the  adjustment in the Exercise  Price and the number and/or type of
securities issuable upon the exercise of the Warrants;  provided,  however, that
the failure of the Company to issue such new Warrant  Certificates  shall not in
any way change,  alter,  or  otherwise  impair,  the rights of the holder as set
forth in the Warrant Agreement.

            Upon due  presentment  for  registration of transfer of this Warrant
Certificate at an office or agency of the Company, a new Warrant  Certificate or
Warrant Certificates of like tenor and evidencing in the aggregate a like number
of Warrants  shall be issued to the  transferee(s)  in exchange for this Warrant
Certificate,  subject to the  limitations  provided  herein  and in the  Warrant
Agreement,  without any charge except for any tax, or other governmental  charge
imposed in connection therewith.

            Upon the exercise of less than all of the Warrants evidenced by this
Certificate,  the  Company  shall  forthwith  issue to the  holder  hereof a new
Warrant Certificate representing such number of unexercised Warrants.

            The Company may deem and treat the  registered  holder(s)  hereof as
the absolute owner(s) of this Warrant Certificate  (notwithstanding any notation
of ownership  or other  writing  hereon made by anyone),  for the purpose of any
exercise hereof,  and of any distribution to the holder(s)  hereof,  and for all
other  purposes,  and the  Company  shall not be  affected  by any notice to the
contrary.

            All terms used in this Warrant  Certificate which are defined in the
Warrant  Agreement  shall  have the  meanings  assigned  to them in the  Warrant
Agreement.

            IN WITNESS WHEREOF,  the Company has caused this Warrant Certificate
to be duly executed under its corporate seal.

Dated: May   , 1995           ALAMAR BIOSCIENCES, INC.

[SEAL]                                


                              By:______________________________________

                                      Name:
                                      Title:

Attest:

______________________________________


<PAGE>



                        [FORM OF ELECTION TO PURCHASE]

            The  undersigned  hereby  irrevocably  elects to exercise the right,
represented  by this  Warrant  Certificate,  to  purchase  _________  Shares and
herewith  tenders in payment for such  Shares in cash or a check  payable to the
order of Alamar Biosciences, Inc. in the amount of $________ , all in accordance
with the terms hereof.  The  undersigned  requests  that a certificate  for such
Shares  be  registered  in  the  name  of  ________________,  whose  address  is
__________________,    and   that   such    Certificate    be    delivered    to
__________________, whose address is _____________.


Dated:                        Signature:________________________________________
                              (Signature must conform in all respects to name of
                              holder  as  specified  on the face of the  Warrant
                              Certificate.)


                       _________________________________

                       _________________________________
                       (Insert Social Security or Other
                        Identifying Number of Holder)



<PAGE>



                             [FORM OF ASSIGNMENT]

       (To be executed by the registered holder if such holder desires to
                       transfer the Warrant Certificate.)

          FOR VALUE RECEIVED  ________________________ hereby sells, assigns and
transfers unto

________________________________________________________________________________
(Please print name and address of transferee)

this Warrant  Certificate,  together with all right, title and interest therein,
and does hereby irrevocably constitute and appoint _______________, Attorney, to
transfer  the  within  Warrant  Certificate  on the  books  of the  within-named
Company, with full power of substitution.


Dated:                        Signature:________________________________________
                              (Signature must conform in all respects to name of
                              holder  as  specified  on the face of the  Warrant
                              Certificate)

_______________________________

_______________________________
(Insert Social Security or Other
Identifying Number of Assignee)





     WARRANT  AGREEMENT dated as of August 18, 1995 between Alamar  BioSciences,
Inc., a California  corporation  (the "Company"),  and  Commonwealth  Associates
(hereinafter referred to as "Commonwealth").

                              W I T N E S S E T H:

     WHEREAS,   the  Company  proposes  to  issue  to  Commonwealth   Associates
("Commonwealth")  warrants  ("Warrants")  to purchase up to 258,700  shares (the
"Shares") of common stock of the Company, no par value (the "Common Stock"); and

     WHEREAS, the Warrants issued pursuant to this Agreement are being issued by
the  Company  to   Commonwealth   and/or  its  designees  in   connection   with
Commonwealth's  role as placement agent for a private placement of the Company's
Common Stock pursuant to the Company's  Confidential  Private Offshore  Offering
Memorandum dated April 19, 1995 and the Company's  Confidential Private Offering
Memorandum dated May 23, 1995;

     NOW,  THEREFORE,   in  consideration  of  the  premises,   the  payment  by
Commonwealth  to the Company of ONE DOLLAR  ($1.00),  the agreements  herein set
forth and other good and valuable consideration,  the receipt and sufficiency of
which are hereby acknowledged, the parties hereto agree as follows:

     1. Grant.

     Commonwealth,  and/or  its  designees,  are  hereby  granted  the  right to
purchase, at any time from August 18, 1995 until 5:00 P.M. New York City time on
August  18,  2000 (the  "Warrant  Exercise  Term"),  up to 258,700  (subject  to
adjustment as provided in Article 8 hereof) Shares at an initial  exercise price
(subject to adjustment as provided in Article 8 hereof) of $0.625 per Share.

     2. Warrant Certificates.

     The warrant certificates (the "Warrant  Certificates")  delivered and to be
delivered  pursuant to this Agreement  shall be in the form set forth as Exhibit
A, attached  hereto and made a part hereof,  with such  appropriate  insertions,
omissions,  substitutions  and other variations as required or permitted by this
Agreement.

     3. Exercise of Warrants.

          3.1 Cash Exercise.  The Warrants  initially are exercisable at a price
of $0.625 per Share, payable in cash or by check to the order of the Company, or
any combination of cash or check, subject to adjustment as provided in Article 8
hereof.  Upon  surrender  of the Warrant  Certificate  with the annexed  Form of
Election to Purchase duly executed,  together with payment of the Exercise Price
(as hereinafter defined) for the Shares


<PAGE>



purchased,  at the Company's  principal  offices  (presently  located at 4110 N.
Freeway  Blvd.,  Sacramento,  CA  95834)  the  registered  holder  of a  Warrant
Certificate  ("Holder" or "Holders")  shall be entitled to receive a certificate
or certificates for the Shares so purchased.  The purchase rights represented by
each Warrant Certificate are exercisable at the option of the Holder thereof, in
whole or in part (but not as to fractional  shares of the Common Stock).  In the
case of the purchase of less than all the Shares  purchasable  under any Warrant
Certificate,  the  Company  shall  cancel  said  Warrant  Certificate  upon  the
surrender  thereof and shall  execute and deliver a new Warrant  Certificate  of
like tenor for the balance of the Shares purchasable thereunder.

          3.2 Cashless  Exercise.  At any time during the Warrant Exercise Term,
the Holder may, at its option,  exchange all or part of the Warrants (a "Warrant
Exchange"), into the number of Shares determined in accordance with this Section
3.2, by  surrendering  his Warrant  Certificate  at the principal  office of the
Company or at the office of its transfer agent,  accompanied by a notice stating
such  holder's  intent  to  effect  such  exchange,  the  number of Shares to be
exchanged and the date on which the Holder  requests that such Warrant  Exchange
occur (the "Notice of Exchange").  The Warrant  Exchange shall take place on the
date  specified in the Notice of Exchange  or, if later,  the date the Notice of
Exchange is received by the Company (the "Exchange Date").  Certificates for the
Shares issuable upon such Warrant Exchange and, if applicable,  a new warrant or
warrants of like tenor evidencing the balance of the Shares remaining subject to
the  Warrants,  shall be issued as of the  Exchange  Date and  delivered  to the
Holder within seven (7) days following the Exchange Date. In connection with any
Warrant Exchange, the Warrant Certificate  surrendered shall represent the right
to subscribe  for and acquire the number of Shares  (rounded to the next highest
integer) equal to (i) the number of Shares specified by the Holder in its Notice
of Exchange  (the "Total  Number")  less (ii) the number of Shares  equal to the
quotient  obtained  by  dividing  (A) the  product  of the Total  Number and the
existing Exercise Price (as hereinafter defined) by (B) the current market value
of a share of Common Stock.

     4. Issuance of Certificates.

     Upon the exercise of the  Warrants,  the issuance of  certificates  for the
Shares shall be made  forthwith  (and in any event within  three  business  days
thereafter) without charge to the Holder thereof including,  without limitation,
any tax which may be  payable  in  respect  of the  issuance  thereof,  and such
certificates  shall (subject to the provisions of Article 5 hereof) be issued in
the name of,  or in such  names  as may be  directed  by,  the  Holder  thereof;
provided,  however,  that the Company shall not be required to pay any tax which
may be payable

                                       -2-


<PAGE>



in respect of any  transfer  involved in the  issuance  and delivery of any such
certificates  in a name other than that of the Holder and the Company  shall not
be required to issue or deliver such certificates  unless or until the person or
persons  requesting  the  issuance  thereof  shall have paid to the  Company the
amount of such tax or shall have  established to the satisfaction of the Company
that such tax has been paid.

     The Warrant Certificates and the certificates representing the Shares shall
be executed on behalf of the Company by the manual or facsimile signature of the
present or any future  Chairman or Vice  Chairman of the Board of  Directors  or
Chief  Executive  Officer,  President or Vice President of the Company under its
corporate  seal  reproduced  thereon,  attested  to by the  manual or  facsimile
signature of the present or any future  Secretary or Assistant  Secretary of the
Company.  Warrant  Certificates  shall be dated  the  date of  execution  by the
Company upon initial issuance, division, exchange, substitution or transfer.

     The Warrant Certificates and, upon exercise of the Warrants,  in part or in
whole,  certificates  representing the Shares shall bear a legend  substantially
similar to the following:

     "The securities  represented by this  certificate  have not been registered
     under the  Securities  Act of 1933, as amended (the "Act"),  and may not be
     offered or sold except (i) pursuant to an effective  registration statement
     under the Act,  (ii) to the extent  applicable,  pursuant to Rule 144 under
     the Act (or any similar rule under such Act relating to the  disposition of
     securities),  or (iii) upon the delivery by the holder to the Company of an
     opinion of  counsel,  reasonably  satisfactory  to counsel to the  Company,
     stating that an exemption from registration under such Act is available."

     5. Investment Restriction.

     The Holder of a Warrant Certificate,  by its acceptance thereof,  covenants
and agrees that the Warrants are being  acquired as an investment and not with a
view to the distribution thereof.

     6. Price.

          6.1 Initial and Adjusted  Exercise Price.  The initial exercise prices
of each Warrant shall be $0.625 per Share. The adjusted  exercise price shall be
the price which shall result from time to time from any and all adjustments of

                                       -3-


<PAGE>



the  initial  exercise  price in  accordance  with the  provisions  of Article 8
hereof.

          6.2 Exercise  Price.  The term "Exercise  Price" herein shall mean the
initial  exercise  price or the  adjusted  exercise  price,  depending  upon the
context.

     7. Registration Rights.

          7.1  Registration  Under the  Securities Act of 1933. The Warrants and
the Shares have not been  registered for purposes of public  distribution  under
the Securities Act of 1933, as amended ("the Act").

          7.2  Registrable  Securities.  As used  herein  the term  "Registrable
Security" means each of the Warrants,  the Shares and any shares of Common Stock
issued  upon any  stock  split or stock  dividend  in  respect  of such  Shares;
provided,  however,  that with respect to any particular  Registrable  Security,
such security  shall cease to be a Registrable  Security when, as of the date of
determination,  (i) it has been effectively  registered under the Securities Act
and disposed of pursuant thereto,  (ii) registration under the Securities Act is
no longer  required for the immediate  public  distribution  of such security or
(iii) it has ceased to be outstanding.  The term "Registrable  Securities" means
any and/or all of the securities  falling  within the foregoing  definition of a
"Registrable   Security."   In  the   event  of  any   merger,   reorganization,
consolidation, recapitalization or other change in corporate structure affecting
the  Common  Stock,   such  adjustment  shall  be  made  in  the  definition  of
"Registrable  Security"  as is  appropriate  in order to prevent any dilution or
enlargement of the rights granted pursuant to this Article 7.

          7.3  Piggyback  Registration.  If, at any time  during the seven years
following the date of this Agreement,  the Company  proposes to prepare and file
any registration statement or post-effective  amendments thereto covering equity
or debt securities of the Company, or any such securities of the Company held by
its  shareholders  (in any such case,  other than in  connection  with a merger,
acquisition  or pursuant to Form S-8 or successor  form),  (for purposes of this
Article 7,  collectively,  a  "Registration  Statement"),  it will give  written
notice of its intention to do so by registered mail ("Notice"),  at least thirty
(30) business days prior to the filing of each such Registration  Statement,  to
all holders of the  Registrable  Securities.  Upon the written request of such a
holder (a  "Requesting  Holder"),  made within  twenty (20)  business days after
receipt of the Notice,  that the Company include any of the Requesting  Holder's
Registrable  Securities  in the  proposed  Registration  Statement,  the Company
shall,  as to each such  Requesting  Holder,  use its best efforts to effect the
registration under the Securities Act

                                       -4-


<PAGE>



of the  Registrable  Securities  which  it has  been so  requested  to  register
("Piggyback  Registration"),  at the  Company's  sole cost and expense and at no
cost or expense to the Requesting Holders.

          7.4 Demand Registration.

               (a) At any time during the Warrant  Exercise  Term, any "Majority
Holder"  (as such term is defined in Section  7.4(d)  below) of the  Registrable
Securities  shall have the right  (which  right is in addition to the  piggyback
registration  rights  provided  for under  Section 7.3 hereof),  exercisable  by
written notice to the Company (the "Demand Registration  Request"),  to have the
Company  prepare  and file with the  Securities  and  Exchange  Commission  (the
"Commission"),  on one occasion,  at the sole expense of the Company (other than
the pro rata portion of  underwriting  discounts,  if any,  attributable  to the
Holder's  Registrable  Securities  and the  expenses  of  Holder's  counsel  and
advisors),  a  Registration  Statement  and such other  documents,  including  a
prospectus,  as may be necessary (in the opinion of both counsel for the Company
and counsel for such Majority Holder), in order to comply with the provisions of
the  Act,  so as to  permit  a  public  offering  and  sale  of the  Registrable
Securities until such time as (i) the sale of all Registrable  Securities by the
holders  thereof  or (ii)  receipt  by the  holders  thereof  of an  opinion  of
Company's  counsel that the Registrable  Securities may be immediately  publicly
sold without registration under the Securities Act.

               (b) The Company  covenants  and agrees to give written  notice of
any Demand  Registration  Request to all holders of the  Registrable  Securities
within ten (10) days from the date of the  Company's  receipt of any such Demand
Registration  Request.  After  receiving  notice from the Company as provided in
this Section 7.4(b),  holders of Registrable  Securities may request the Company
to include  their  Registrable  Securities in the  Registration  Statement to be
filed  pursuant  to Section  7.4(a)  hereof by  notifying  the  Company of their
decision to include such securities within ten (10) days of their receipt of the
Company's notice.

               (c) The term "Majority  Holder" as used in this Section 7.4 shall
mean any holder or any  combination  of holders of  Registrable  Securities,  if
included in such holders'  Registrable  Securities are that aggregate  number of
Shares  (including  Shares  already issued and Shares  issuable  pursuant to the
exercise  of  outstanding  Warrants)  as  would  constitute  a  majority  of the
aggregate number of Shares  (including Shares already issued and Shares issuable
pursuant  to  the  exercise  of  outstanding  Warrants)  included  in all of the
Registrable Securities.


                                      -5-


<PAGE>



          7.5 Covenants of the Company With Respect to Registration. The Company
covenants and agrees as follows:

               (a) In connection with any registration under Section 7.4 hereof,
the Company shall file the Registration  Statement as expeditiously as possible,
but in no event later than twenty (20)  business days  following  receipt of any
demand  therefor,  shall  use its best  efforts  to have  any such  Registration
Statements  declared  effective at the earliest possible time, and shall furnish
each  holder of  Registrable  Securities  such number of  prospectuses  as shall
reasonably  be  requested.  In connection  with the  obligations  of the Company
hereunder  to  register  a Holder's  Registrable  Securities,  the Holder  shall
furnish  the Company  such  information  concerning  the  Holder,  the  Holder's
Registrable  Securities  and the  terms  of the  offering  of  such  Registrable
Securities  by the  Holder as the  Company  may  reasonably  request in order to
comply with the provisions of the Act with resect to the Registration  Statement
to be filed.

               (b) Other than fees and disbursements of counsel acting on behalf
of the  holders  of  Registrable  Securities  and the pro  rata  portion  of the
underwriting  discounts and  commissions,  if any,  attributable  to Registrable
Securities,  the Company  shall pay all costs,  fees and expenses in  connection
with all  Registration  Statements  filed  pursuant to  Sections  7.3 and 7.4(a)
hereof including,  without limitation,  the Company's legal and accounting fees,
printing expenses, and blue sky fees and expenses.

               (c) The  Company  will  take all  necessary  action  which may be
required in qualifying or registering the Registrable  Securities  included in a
Registration  Statement  for offering and sale under the  securities or blue sky
laws of such states as are requested by the holders of such securities, provided
that the Company  shall not be obligated to execute or file any general  consent
to service of process  or to  qualify as a foreign  corporation  to do  business
under the laws of any such jurisdiction.

               (d) The Company  shall  indemnify  any holder of the  Registrable
Securities to be sold pursuant to any Registration Statement and any underwriter
or person deemed to be an underwriter under the Act and each person, if any, who
controls such holder or underwriter or person deemed to be an underwriter within
the meaning of Section 15 of the Act or Section 20(a) of the Securities Exchange
Act of 1934, as amended  ("Exchange  Act"), from and against any and all losses,
claims,  damages,  expenses and liabilities  (including all expenses  reasonably
incurred in investigating,  preparing or defending against any claim whatsoever)
caused by any untrue  statement of a material fact contained in the Registration
Statement, any other registration

                                       -6-


<PAGE>



statement  filed by the Company under the Act, any  post-effective  amendment to
such registration statements,  or any prospectus included therein required to be
filed or  furnished  by reason of this  Agreement  or caused by any  omission or
alleged  omission to state therein a material fact required to be stated therein
or necessary to make the statements  therein not  misleading,  except insofar as
such losses,  claims,  damages,  expenses or liabilities  are caused by any such
untrue  statement or alleged  untrue  statement or omission or alleged  omission
based upon  information  furnished or required to be furnished in writing to the
company  by  the  Holder  or  underwriter  expressly  for  use  therein;   which
indemnification  shall include each person, if any, who controls any such Holder
or  underwriter  within  the  meaning  of the Act and  each  officer,  director,
employee and agent of such Holder or underwriter;  provided,  however,  that the
Company  shall  not  be  obligated  to so  indemnify  the  Holder  or  any  such
underwriter  or other person  referred to above unless the Holder or underwriter
or other  person,  as the case may be,  shall  at the same  time  indemnify  the
Company, its directors, each officer signing the registration statement and each
person, if any, who controls the Company within the meaning of the Act, from and
against any and all losses, claims, damages,  expenses and liabilities caused by
any untrue statement or alleged untrue statement of a material fact contained in
the  registration  Statement,  any  registration  statement  or  any  prospectus
required to be filed or furnished  by reason of this  Agreement or caused by any
omission  to state  therein a material  fact  required  to be stated  therein or
necessary to make the statements therein not misleading, insofar as such losses,
claims,  damages,  expenses or liabilities are caused by any untrue statement or
alleged untrue statement or omission based upon information furnished in writing
to the  Company by the Holder or  underwriter  expressly  for use  therein,  and
provided,  further that the holder, each person, if any, who controls the holder
within the meaning of the Act,  and each of the  Holder's  directors,  officers,
employees and agents shall not be obligated to indemnify any indemnified  person
pursuant to the foregoing  indemnity,  or to make any  contribution  pursuant to
subparagraph  7.5(f) below, in an amount in excess of the net proceeds  received
by such holder with respect to the sale of Registrable Securities.

               (e) Promptly after receipt of notice of the  commencement  of any
action in respect of which  indemnity  may be sought  against  any  indemnifying
party under this Section 7.5, the indemnified party will notify the indemnifying
party in writing of the commencement  thereof,  and the indemnifying party will,
subject to the provisions  hereinafter stated, assume the defense of such action
(including  the  employment  of counsel  reasonably  subject  to the  provisions
hereinafter stated,  assume the defense of such action (including the employment
of counsel reasonably satisfactory to the indemnified party and the payment of

                                       -7-


<PAGE>



expenses)  insofar as such action relates to an alleged  liability in respect of
which indemnity may be sought against the indemnifying  party. After notice from
the  indemnifying  party of its  election to assume the defense of such claim or
action,  the  indemnifying  party  shall no longer by liable to the  indemnified
party  under  this  Section  7.5 for any  legal or other  expenses  subsequently
incurred by the  indemnified  party in connection with the defense thereof other
than  reasonable  costs of  investigation;  provided,  however,  that if, in the
written opinion of counsel to the indemnified party or parties,  it is advisable
for the indemnified party or parties,  it is advisable for the indemnified party
or parties to be  represented  by separate  counsel,  the  indemnified  party or
parties  shall  have the  right to  employ a single  counsel  to  represent  the
indemnified  parties who may be subject to liability arising out of any claim in
respect of which  indemnity  may be sought by the  indemnified  parties  thereof
against the indemnifying  party, in which event the reasonable fees and expenses
of such separate  counsel shall be borne by the  indemnifying  party.  Any party
against whom  indemnification  may be sought under this Section 7.5 shall not be
liable to  indemnify  any person that might  otherwise be  indemnified  pursuant
hereto for any  settlement  of any action  effected  without  such  indemnifying
party's consent, which consent shall not be unreasonably withheld.

               (f) If for any reason the  indemnification  provided  for in this
Section 7.5 is held by a court of competent jurisdiction to be unavailable to an
indemnified party with respect to any loss, claim, damage,  expense or liability
referred to therein,  then the indemnifying  party, in lieu of indemnifying such
indemnified party thereunder,  shall contribute to the amount paid or payable by
the  indemnified  party as a result of such  loss,  claim,  damage,  expense  or
liability in such  proportion as is appropriate to reflect not only the relative
benefits received by the indemnified party and the indemnifying  party, but also
the relative fault of the indemnified party and the indemnifying  party, as well
as any other relevant equitable considerations.

               (g) Nothing  contained  in this  Agreement  shall be construed as
requiring any Holder to exercise his Warrants prior to the initial filing of any
Registration Statement or the effectiveness thereof.

     8. Adjustments of Exercise Price and Number of Shares.

          8.1 Computation of Adjusted Price. Except as hereinafter  provided, in
case the  Company  shall at any time  after  the date  hereof  issue or sell any
shares of Common Stock (other than the issuances or sales referred to in Section
8.6  hereof),  including  shares held in the  Company's  treasury  and shares of
Common Stock issued upon the exercise of any options, rights or

                                       -8-


<PAGE>



warrants to subscribe  for shares of Common  Stock (other than the  issuances or
sales of Common  Stock  pursuant to rights to  subscribe  for such Common  Stock
distributed  to all the  shareholders  of the  Company  and  Holders of Warrants
pursuant  to Section  8.8  hereof)  and shares of Common  Stock  issued upon the
direct or indirect  conversion  or exchange of  securities  for shares of Common
Stock,  for a  consideration  per share less than either the  Exercise  Price in
effect  immediately  prior to the issuance or sale of such shares or the "Market
Price" (as  defined  in Section  8.1(vi)  hereof)  per share of Common  Stock or
without  consideration,  then forthwith upon such issuance or sale, the Exercise
Price shall  (until  another  such  issuance  or sale),  be reduced to the price
(calculated to the nearest full cent) equal to the quotient  derived by dividing
(A) an amount  equal to the sum of (X) the  product  of (a) the total  number of
shares of Common Stock  outstanding  immediately prior to such issuance or sale,
multiplied  by (b) the lower of (i) the  Exercise  Price in  effect  immediately
prior to such  issuance  or sale or (ii)  the  "Market  Price"  (as  defined  in
subsection  (vi) of this  Section 8.1  hereof) per share of Common  Stock on the
date  immediately  prior to the issuance or sale of such shares,  plus,  (Y) the
aggregate of the amount of all  consideration,  if any,  received by the Company
upon such  issuance or sale,  by (B) the total  number of shares of Common Stock
outstanding immediately after such issuance or sale; provided,  however, that in
no event shall the Exercise Price be adjusted pursuant to this computation to an
amount in  excess of the  Exercise  Price in  effect  immediately  prior to such
computation, except in the case of a combination of outstanding shares of Common
Stock, as provided by Section 8.3 hereof.

     For the  purposes of any  computation  to be made in  accordance  with this
Section 8.1, the following provisions shall be applicable:

                    (i) In case of the  issuance  or sale of  shares  of  Common
Stock for a consideration  part or all of which shall be cash, the amount of the
cash consideration therefor shall be deemed to be the amount of cash received by
the Company  for such  shares (or, if shares of Common  Stock are offered by the
Company for subscription,  the subscription  price, or, if such securities shall
be sold to underwriters  or dealers for public  offering  without a subscription
offering,  the initial public  offering  price) before  deducting  therefrom any
compensation  paid or  discount  allowed in the sale,  underwriting  or purchase
thereof by underwriters or dealers or others performing similar services, or any
expenses incurred in connection therewith.

                    (ii) In case of the  issuance or sale  (otherwise  than as a
dividend or other  distribution on any stock of the Company) of shares of Common
Stock for a consideration

                                       -9-


<PAGE>



part or all of which shall be other than cash,  the amount of the  consideration
therefor  other than cash shall be deemed to be the value of such  consideration
as determined in good faith by the Board of Directors of the Company.

                    (iii) Shares of Common Stock  issuable by way of dividend or
other  distribution  on any  stock of the  Company  shall be deemed to have been
issued immediately after the opening of business on the day following the record
date for the determination of shareholders  entitled to receive such dividend or
other   distribution   and  shall  be  deemed  to  have  been   issued   without
consideration.

                    (iv) The reclassification of securities of the Company other
than shares of Common  Stock into  securities  including  shares of Common Stock
shall be deemed to involve the  issuance  of such  shares of Common  Stock for a
consideration  other than cash immediately prior to the close of business on the
date fixed for the  determination  of security  holders entitled to receive such
shares,  and the value of the  consideration  allocable to such shares of Common
Stock shall be determined as provided in subsection (ii) of this Section 8.1.

                    (v) The  number of  shares  of Common  Stock at any one time
outstanding shall include the aggregate number of shares issued or issuable upon
the exercise of options, rights, warrants and upon the conversion or exchange of
convertible or exchangeable securities.

                    (vi) As used herein,  the phrase  "Market Price" at any date
shall be deemed to be the last reported sale price, or, in case no such reported
sale takes place on such day, the average of the last  reported  sale prices for
the last three  trading  days,  in either  case as  officially  reported  by the
principal securities exchange on which the Common Stock is listed or admitted to
trading or as reported in the NASDAQ National  Market System,  or, if the Common
Stock is not listed or admitted to trading on any national  securities  exchange
or quoted  on the  NASDAQ  National  Market  System,  the  closing  bid price as
furnished by the National Association of Securities Dealers, Inc. through NASDAQ
or similar organization if NASDAQ is no longer reporting such information, or if
the  Common  Stock is not  quoted on  NASDAQ,  as  determined  in good  faith by
resolution  of  the  Board  of  Directors  of the  Company,  based  on the  best
information available to it for the two days immediately preceding such issuance
or sale and the day of such issuance or sale.

          8.2  Options,   Rights,  Warrants  and  Convertible  and  Exchangeable
Securities.  Except in the case of the Company  issuing  rights to subscribe for
shares of Common Stock  distributed to all the  shareholders  of the Company and
Holders of

                                      -10-


<PAGE>



Warrants  pursuant to Section 8.8 hereof, if the Company shall at any time after
the date hereof issue  options,  rights or warrants to  subscribe  for shares of
Common Stock,  or issue any  securities  convertible  into or  exchangeable  for
shares of Common  Stock,  (i) for a  consideration  per share  less than (a) the
Exercise  Price in effect  immediately  prior to the  issuance of such  options,
rights or warrants, or such convertible or exchangeable  securities,  or (b) the
Market  Price,  or (ii)  without  consideration,  the  Exercise  Price in effect
immediately prior to the issuance of such options,  rights or warrants,  or such
convertible or exchangeable securities,  as the case may be, shall be reduced to
a price  determined by making a computation in accordance with the provisions of
Section 8.1 hereof, provided that:

               (a) The aggregate  maximum  number of shares of Common Stock,  as
the case may be, issuable under all the outstanding options,  rights or warrants
shall be deemed to be issued  and  outstanding  at the time all the  outstanding
options,  rights or warrants were issued,  and for a consideration  equal to the
minimum purchase price per share provided for in the options, rights or warrants
at the time of issuance,  plus the consideration  (determined in the same manner
as consideration  received on the issue or sale of shares in accordance with the
terms of the Warrants),  if any, received by the Company for the options, rights
or  warrants,  and if no minimum  price is  provided in the  options,  rights or
warrants, then the consideration shall be equal to zero; provided, however, that
upon the expiration or other termination of the options,  rights or warrants, if
any thereof shall not have been exercised,  the number of shares of Common Stock
deemed to be issued and outstanding pursuant to this subsection (a) (and for the
purposes  of  subsection  (v) of Section  8.1  hereof)  shall be reduced by such
number of shares as to which options,  warrants and/or rights shall have expired
or terminated  unexercised,  and such number of shares shall no longer be deemed
to be issued  and  outstanding,  and the  Exercise  Price  then in effect  shall
forthwith be readjusted and thereafter be the price which it would have been had
adjustment been made on the basis of the issuance only of shares actually issued
or issuable upon the exercise of those  options,  rights or warrants as to which
the exercise rights shall not have expired or terminated unexercised.

               (b) The  aggregate  maximum  number of  shares  of  Common  Stock
issuable  upon  conversion  or  exchange  of  any  convertible  or  exchangeable
securities  shall be deemed to be issued and outstanding at the time of issuance
of  such  securities,  and  for  a  consideration  equal  to  the  consideration
(determined in the same manner as consideration received on the issue or sale of
shares of Common Stock in accordance with the terms of the Warrants) received by
the  Company  for such  securities,  plus  the  minimum  consideration,  if any,
receivable  by the Company upon the  conversion or exchange  thereof;  provided,
however, that upon

                                      -11-


<PAGE>



the  termination  of the  right to  convert  or  exchange  such  convertible  or
exchangeable  securities  (whether by reason of  redemption or  otherwise),  the
number of shares deemed to be issued and outstanding pursuant to this subsection
(b) (and for the  purpose of  subsection  (v) of Section  8.1  hereof)  shall be
reduced by such number of shares as to which the  conversion or exchange  rights
shall have expired or terminated unexercised, and such number of shares shall no
longer be deemed to be issued and  outstanding  and the  Exercise  Price then in
effect shall  forthwith be readjusted and thereafter be the price which it would
have been had  adjustment  been made on the  basis of the  issuance  only of the
shares  actually  issued or issuable  upon the  conversion  or exchange of those
convertible  or  exchangeable  securities as to which the conversion or exchange
rights shall not have expired or terminated unexercised.

               (c) If any change shall occur in the price per share provided for
in any of the options,  rights or warrants referred to in subsection (a) of this
Section  8.2, or in the price per share at which the  securities  referred to in
subsection (b) of this Section 8.2 are convertible or exchangeable, the options,
rights or warrants or conversion or exchange  rights,  as the case may be, shall
be deemed to have  expired  or  terminated  on the date when such  price  change
became  effective in respect of shares not  theretofore  issued  pursuant to the
exercise or conversion or exchange  thereof,  and the Company shall be deemed to
have issued upon such date new  options,  rights or warrants or  convertible  or
exchangeable  securities  at the new price in  respect  of the  number of shares
issuable upon the exercise of such options, rights or warrants or the conversion
or exchange of such convertible or exchangeable securities.

          8.3 Subdivision and Combination. In case the Company shall at any time
subdivide or combine the outstanding  shares of Common Stock, the Exercise Price
shall  forthwith  be  proportionately  decreased in the case of  subdivision  or
increased in the case of combination.

          8.4  Adjustment  in Number of  Shares.  Upon  each  adjustment  of the
Exercise  Price  pursuant  to the  provisions  of this  Article 8, the number of
Shares  issuable  upon the  exercise  of each  Warrant  shall be adjusted to the
nearest full Share by multiplying a number equal to the Exercise Price in effect
immediately  prior to such  adjustment  by the  number of Shares  issuable  upon
exercise of the Warrants  immediately  prior to such adjustment and dividing the
product so obtained by the adjusted Exercise Price.

          8.5  Reclassification,  Consolidation,  Merger,  etc.  In  case of any
reclassification or change of the outstanding shares of Common Stock (other than
a change in par value to no

                                      -12-


<PAGE>



par value, or from no par value to par value, or as a result of a subdivision or
combination), or in the case of any consolidation of the Company with, or merger
of the Company into,  another  corporation (other than a consolidation or merger
in which the Company is the surviving  corporation  and which does not result in
any reclassification or change of the outstanding shares of Common Stock, except
a change as a result of a subdivision  or combination of such shares or a change
in par value,  as aforesaid),  or in the case of a sale or conveyance to another
corporation  of the  property of the Company as an entirety,  the Holders  shall
thereafter have the right to purchase the kind and number of shares of stock and
other  securities and property  receivable upon such  reclassification,  change,
consolidation,  merger,  sale or conveyance as if the Holders were the owners of
the shares of Common Stock underlying the Warrants immediately prior to any such
events at a price equal to the product of (x) the number of shares issuable upon
exercise of the Warrants and (y) the Exercise Price in effect  immediately prior
to the record date for such  reclassification,  change,  consolidation,  merger,
sale or conveyance as if such Holders had exercised the Warrants.

          8.6 No Adjustment of Exercise Price in Certain Cases. No adjustment of
the Exercise Price shall be made:

               (a) Upon the  issuance or sale of shares of Common Stock upon the
          exercise of the Warrants;

               (b) Upon  (i) the  issuance  of  options  pursuant  to any of the
          Company's  employee stock option plans in effect on the date hereof or
          any  employee  stock  option  plan  adopted  after the date  hereof by
          stockholders of the Company the issuance or sale by the Company of any
          shares of Common Stock  pursuant to the exercise of any such  options,
          or (ii) the  issuance  or sale by the  Company of any shares of Common
          Stock  pursuant to the exercise of any options or warrants  previously
          issued and outstanding on the date hereof;

               (c) Upon  issuance  of any  shares  of Common  Stock  sold in the
          Company's  offerings  of an  aggregate  of up to  4,000,000  shares of
          Common  Stock  being  conducted  pursuant  to the  Company's  Offering
          Memoranda dated April 19, 1995 and April 21, 1995, respectively; or

               (d) Upon the issuance of any shares of Common Stock in connection
          with the Company's merger with AccuMed, Inc.

          8.7  Dividends  and Other  Distributions  with Respect to  Outstanding
Securities. In the event that the Company

                                      -13-


<PAGE>



shall at any time  prior to the  exercise  of all  Warrants  declare a  dividend
(other  than a dividend  consisting  solely of shares of Common  Stock or a cash
dividend  or  distribution  payable  out of current  or  retained  earnings)  or
otherwise distribute to its shareholders any monies, assets,  property,  rights,
evidences  of  indebtedness,  securities  (other than  shares of Common  Stock),
whether issued by the Company or by another person or entity, or any other thing
of value, the Holder or Holders of the unexercised  Warrants shall thereafter be
entitled,  in  addition  to the  shares  of  Common  Stock or  other  securities
receivable  upon the  exercise  thereof,  to receive,  upon the exercise of such
Warrants, the same monies, property,  assets, rights, evidences of indebtedness,
securities  or any other  thing of value that they would have been  entitled  to
receive at the time of such  dividend or  distribution.  At the time of any such
dividend or distribution,  the Company shall make appropriate reserves to ensure
the timely performance of the provisions of this Subsection 8.7.

          8.8   Subscription   Rights  for  Shares  of  Common  Stock  or  Other
Securities.  In the case the Company or an affiliate of the Company shall at any
time after the date hereof and prior to the exercise of all the  Warrants  issue
any rights to subscribe  for shares of Common Stock or any other  securities  of
the Company or of such  affiliate to all the  shareholders  of the Company,  the
Holders of the unexercised Warrants shall be entitled, in addition to the shares
of  Common  Stock or  other  securities  receivable  upon  the  exercise  of the
Warrants,  to receive such rights at the time such rights are distributed to the
other shareholders of the Company.

          9. Exchange and Replacement of Warrant Certificates.

     Each  Warrant  Certificate  is  exchangeable  without  expense,   upon  the
surrender hereof by the registered  Holder at the principal  executive office of
the Company,  for a new Warrant  Certificate of like tenor and date representing
in the  aggregate  the  right to  purchase  the same  number  of  Shares in such
denominations  as shall be designated by the Holder  thereof at the time of such
surrender.

     Upon receipt by the Company of evidence  reasonably  satisfactory  to it of
the loss, theft,  destruction or mutilation of any Warrant Certificate,  and, in
case of  loss,  theft  or  destruction,  of  indemnity  or  security  reasonably
satisfactory to it, and reimbursement to the Company of all reasonable  expenses
incidental  thereto,  and upon surrender and  cancellation  of the Warrants,  if
mutilated,  the Company will make and deliver a new Warrant  Certificate of like
tenor, in lieu thereof.



                                      -14-


<PAGE>



     10. Elimination of Fractional Interests.

     The  Company  shall  not be  required  to issue  certificates  representing
fractions  of shares of Common Stock and shall not be required to issue scrip or
pay cash in lieu of  fractional  interests,  it being the intent of the  parties
that all fractional interests shall be eliminated by rounding any fraction up to
the nearest whole number of shares of Common Stock.

     11. Reservation and Listing of Securities.

     The  Company  shall at all  times  reserve  and keep  available  out of its
authorized  shares of Common Stock,  solely for the purpose of issuance upon the
exercise  of the  Warrants,  such  number of shares of Common  Stock as shall be
issuable upon the exercise thereof.  The Company covenants and agrees that, upon
exercise of the Warrants and payment of the Exercise Price therefor,  all shares
of Common Stock  issuable upon such exercise  shall be duly and validly  issued,
fully  paid,  non-assessable  and not  subject to the  preemptive  rights of any
shareholder. As long as the Warrants shall be outstanding, the Company shall use
its best efforts to cause all shares of Common Stock  issuable upon the exercise
of the  Warrants to be listed on or quoted by NASDAQ or listed on such  national
securities exchanges as requested by Commonwealth.

     12. Notices to Warrant Holders.

     Nothing  contained in this Agreement  shall be construed as conferring upon
the Holder or Holders the right to vote or to consent or to receive  notice as a
shareholder  in respect of any  meetings  of  shareholders  for the  election of
directors  or  any  other  matter,  or as  having  any  rights  whatsoever  as a
shareholder of the Company.  If, however, at any time prior to the expiration of
the Warrants and their exercise, any of the following events shall occur:

          (a) the  Company  shall take a record of the  holders of its shares of
     Common  Stock for the  purpose of  entitling  them to receive a dividend or
     distribution  payable  otherwise  than  in  cash,  or a  cash  dividend  or
     distribution payable otherwise than out of current or retained earnings, as
     indicated by the accounting  treatment of such dividend or  distribution on
     the books of the Company; or

          (b) the Company shall offer to all the holders of its Common Stock any
     additional shares of capital stock of the Company or securities convertible
     into or exchangeable for shares of capital stock of the

                                      -15-


<PAGE>



     Company, or any option, right or warrant to subscribe therefor; or

          (c) a  dissolution,  liquidation  or winding up of the Company  (other
     than in  connection  with a  consolidation  or  merger) or a sale of all or
     substantially all of its property, assets and business as an entirety shall
     be proposed;

then, in any one or more of said events,  the Company shall give written  notice
of such  event at least  fifteen  (15) days  prior to the date fixed as a record
date or the date of closing  the  transfer  books for the  determination  of the
shareholders   entitled  to  such   dividend,   distribution,   convertible   or
exchangeable securities or subscription rights, options or warrants, or entitled
to vote on such  proposed  dissolution,  liquidation,  winding up or sale.  Such
notice shall specify such record date or the date of closing the transfer books,
as the case may be.  Failure to give such notice or any defect therein shall not
affect the validity of any action taken in connection  with the  declaration  or
payment of any such dividend or distribution, or the issuance of any convertible
or exchangeable  securities or subscription rights,  options or warrants, or any
proposed dissolution, liquidation, winding up or sale.

     13. Notices.

     All notices, requests, consents and other communications hereunder shall be
in writing and shall be deemed to have been duly made when delivered,  or mailed
by registered or certified mail, return receipt requested:

          (a) If to a registered Holder of the Warrants,  to the address of such
Holder as shown on the books of the Company; or

          (b) If to the  Company,  to the address set forth in Section 3 of this
Agreement or to such other address as the Company may designate by notice to the
Holders.

     14. Supplements and Amendments.

     The Company and Commonwealth may from time to time supplement or amend this
Agreement  without the approval of any Holders of Warrant  Certificates in order
to cure any ambiguity,  to correct or supplement any provision  contained herein
which may be defective or inconsistent  with any provisions  herein,  or to make
any other provisions in regard to matters or questions  arising  hereunder which
the Company and  Commonwealth  may deem  necessary  or  desirable  and which the
Company and  Commonwealth  deem not to  adversely  affect the  interests  of the
Holders of Warrant Certificates.

                                      -16-


<PAGE>




     15. Successors.

     All the covenants and provisions of this Agreement by or for the benefit of
the Company and the Holders inure to the benefit of their respective  successors
and assigns hereunder.

     16. Termination.

     This Agreement shall terminate at the close of business on August 18, 2003.
Notwithstanding the foregoing, this Agreement will terminate on any earlier date
when all Warrants have been exercised and all the Shares  issuable upon exercise
of the  Warrants  have been resold to the public;  provided,  however,  that the
provisions  of Section 7.5 shall  survive  such  termination  until the close of
business on August 18, 2006.

     17. Governing Law.

     This  Agreement  and each Warrant  Certificate  issued  hereunder  shall be
deemed to be a contract made under the laws of the State of New York and for all
purposes shall be construed in accordance with the laws of said State.

     18. Benefits of This Agreement.

     Nothing  in this  Agreement  shall be  construed  to give to any  person or
corporation  other than the Company and  Commonwealth  and any other  registered
holder or holders of the Warrant Certificates,  Warrants or the Shares any legal
or equitable  right,  remedy or claim under this  Agreement;  and this Agreement
shall be for the sole and exclusive  benefit of the Company and Commonwealth and
any other holder or holders of the Warrant Certificates, Warrants or the Shares.


                                      -17-


<PAGE>




     19. Counterparts.

     This  Agreement may be executed in any number of  counterparts  and each of
such counterparts  shall for all purposes be deemed to be an original,  and such
counterparts shall together constitute but one and the same instrument.

     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
duly executed, as of the day and year first above written.


[SEAL]                                      ALAMAR BIOSCIENCES, INC.


                                            By:_________________________________
                                                Name:
                                                Title:
Attest:

____________________________


                                            COMMONWEALTH ASSOCIATES

                                            By: Commonwealth Associates
                                                Management Company, Inc.,
                                                General Partner


                                            By:_________________________________
                                                Name:
                                                Title:

                                      -18-


<PAGE>





THE WARRANTS  REPRESENTED BY THIS CERTIFICATE AND THE OTHER SECURITIES  ISSUABLE
UPON EXERCISE THEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED (THE "ACT"), AND MAY NOT BE OFFERED OR SOLD EXCEPT (i) PURSUANT TO AN
EFFECTIVE  REGISTRATION  STATEMENT UNDER THE ACT, (ii) TO THE EXTENT APPLICABLE,
PURSUANT TO RULE 144 UNDER SUCH ACT (OR ANY SIMILAR RULE UNDER SUCH ACT RELATING
TO THE DISPOSITION OF  SECURITIES),  OR (iii) UPON THE DELIVERY BY THE HOLDER TO
THE COMPANY OF AN OPINION OF COUNSEL, REASONABLY SATISFACTORY TO COUNSEL FOR THE
COMPANY,  STATING  THAT  AN  EXEMPTION  FROM  REGISTRATION  UNDER  SUCH  ACT  IS
AVAILABLE.

THE  TRANSFER OR EXCHANGE OF THE WARRANTS  REPRESENTED  BY THIS  CERTIFICATE  IS
RESTRICTED IN ACCORDANCE WITH THE WARRANT AGREEMENT REFERRED TO HEREIN.

                            EXERCISABLE ON OR BEFORE
                 5:00 P.M., NEW YORK CITY TIME, AUGUST 18, 2000

No. WA-1                                                        258,700 Warrants

                               WARRANT CERTIFICATE

     This   Warrant   Certificate   certifies   that   Commonwealth   Associates
("Commonwealth")  or registered  assigns,  is the  registered  holder of 258,700
Warrants to purchase,  at any time from August 18, 1995 until 5:00 P.M. New York
City time on  August  18,  2000 (the  "Expiration  Date") up to  258,700  shares
("Shares") of fully-paid and non-assessable  common stock, no par value ("Common
Stock"), of Alamar BioSciences,  Inc., a California corporation (the "Company"),
at the initial  exercise  price,  subject to adjustment  in certain  events (the
"Exercise  Price"),  of  $0.625  per  Share,  upon  surrender  of  this  Warrant
Certificate  and  payment  of the  Exercise  Price at an office or agency of the
Company,  but  subject to the  conditions  set forth  herein and in the  warrant
agreement dated as of August 18, 1995 between the Company and Commonwealth  (the
"Warrant  Agreement").  Payment of the Exercise Price may be made in cash, or by
check payable to the order of the Company, or any combination of cash or check.

     No Warrant may be  exercised  after 5:00 P.M.,  New York City time,  on the
Expiration Date, at which time all Warrants  evidenced hereby,  unless exercised
prior thereto, shall thereafter be void.

     The  Warrants  evidenced  by this  Warrant  Certificate  are part of a duly
authorized  issue of Warrants  issued pursuant to the Warrant  Agreement,  which
Warrant Agreement is hereby incorporated by reference in and made a part of this
instrument and is hereby referred to in a description of the rights,  limitation
of rights, obligations, duties and immunities thereunder of the


<PAGE>



Company and the holders (the words "holders" or "holder"  meaning the registered
holders or registered holder) of the Warrants.

     The Warrant Agreement  provides that upon the occurrence of certain events,
the Exercise Price and/or number of the Company's  securities issuable thereupon
may,  subject to certain  conditions,  be adjusted.  In such event,  the Company
will, at the request of the holder,  issue a new Warrant Certificate  evidencing
the  adjustment  in the Exercise  Price and the number and/or type of securities
issuable upon the exercise of the Warrants;  provided, however, that the failure
of the  Company  to issue  such new  Warrant  Certificates  shall not in any way
change, alter, or otherwise impair, the rights of the holder as set forth in the
Warrant Agreement.

     Upon  due  presentment  for   registration  of  transfer  of  this  Warrant
Certificate at an office or agency of the Company, a new Warrant  Certificate or
Warrant Certificates of like tenor and evidencing in the aggregate a like number
of Warrants  shall be issued to the  transferee(s)  in exchange for this Warrant
Certificate,  subject to the  limitations  provided  herein  and in the  Warrant
Agreement,  without any charge except for any tax, or other governmental  charge
imposed in connection therewith.

     Upon the  exercise  of less  than  all of the  Warrants  evidenced  by this
Certificate,  the  Company  shall  forthwith  issue to the  holder  hereof a new
Warrant Certificate representing such number of unexercised Warrants.

     The  Company  may deem and treat  the  registered  holder(s)  hereof as the
absolute owner(s) of this Warrant Certificate  (notwithstanding  any notation of
ownership  or other  writing  hereon  made by  anyone),  for the  purpose of any
exercise hereof,  and of any distribution to the holder(s)  hereof,  and for all
other  purposes,  and the  Company  shall not be  affected  by any notice to the
contrary.

     All terms used in this Warrant Certificate which are defined in the Warrant
Agreement shall have the meanings assigned to them in the Warrant Agreement.

     IN WITNESS WHEREOF,  the Company has caused this Warrant  Certificate to be
duly executed under its corporate seal.

Dated: May   3, 1995                          ALAMAR BIOSCIENCES, INC.

[SEAL]                                        By:__________________________
                                                  Name:
                                                  Title:
Attest:

_______________________________


<PAGE>



                         [FORM OF ELECTION TO PURCHASE]

     The  undersigned   hereby   irrevocably   elects  to  exercise  the  right,
represented  by this  Warrant  Certificate,  to  purchase  _________  Shares and
herewith  tenders in payment for such  Shares in cash or a check  payable to the
order of Alamar  Biosciences,  Inc. in the amount of $_____ , all in  accordance
with the terms hereof.  The  undersigned  requests  that a certificate  for such
Shares  be  registered  in the  name of  ________________  ,  whose  address  is
__________________,    and   that   such    Certificate    be    delivered    to
__________________, whose address is _____________.


Dated:                                  Signature:________________________

                                        (Signature  must conform in
                                        all  respects  to  name  of
                                        holder as  specified on the
                                        face    of   the    Warrant
                                        Certificate.)

                                         ________________________________

                                         ________________________________
                                         (Insert Social Security or Other
                                          Identifying Number of Holder)



<PAGE>



                              [FORM OF ASSIGNMENT]

             (To be executed by the registered holder if such holder
                  desires to transfer the Warrant Certificate.)


     FOR VALUE RECEIVED_________________________________________________________
hereby sells, assigns and transfers unto

________________________________________________________________________________
(Please print name and address of transferee)

this Warrant  Certificate,  together with all right, title and interest therein,
and does hereby irrevocably constitute and appoint _______________, Attorney, to
transfer  the  within  Warrant  Certificate  on the  books  of the  within-named
Company, with full power of substitution.


Dated:                                    Signature:_____________________
               
                                          (Signature must conform in all
                                          respects to name of holder as
                                          specified on the face of the
                                          Warrant Certificate)


________________________________

________________________________
(Insert Social Security or Other
Identifying Number of Assignee)




     WARRANT  AGREEMENT dated as of August 22, 1995 between Alamar  BioSciences,
Inc., a California  corporation  (the "Company"),  and  Commonwealth  Associates
(hereinafter referred to as "Commonwealth").


                              W I T N E S S E T H:


     WHEREAS,   the  Company  proposes  to  issue  to  Commonwealth   Associates
("Commonwealth")  warrants  ("Warrants")  to purchase  up to 41,300  shares (the
"Shares") of common stock of the Company, no par value (the "Common Stock"); and


     WHEREAS, the Warrants issued pursuant to this Agreement are being issued by
the  Company  to   Commonwealth   and/or  its  designees  in   connection   with
Commonwealth's  role as placement agent for a private placement of the Company's
Common Stock pursuant to the Company's  Confidential  Private Offshore  Offering
Memorandum dated April 19, 1995 and the Company's  Confidential Private Offering
Memorandum dated May 23, 1995;


     NOW,  THEREFORE,   in  consideration  of  the  premises,   the  payment  by
Commonwealth  to the Company of ONE DOLLAR  ($1.00),  the agreements  herein set
forth and other good and valuable consideration,  the receipt and sufficiency of
which are hereby acknowledged, the parties hereto agree as follows:


     1. Grant.

     Commonwealth,  and/or  its  designees,  are  hereby  granted  the  right to
purchase, at any time from August 22, 1995 until 5:00 P.M. New York City time on
August  22,  2000  (the  "Warrant  Exercise  Term"),  up to 41,300  (subject  to
adjustment as provided in Article 8 hereof) Shares at an initial  exercise price
(subject to adjustment as provided in Article 8 hereof) of $0.625 per Share.

     2. Warrant Certificates.

     The warrant certificates (the "Warrant  Certificates")  delivered and to be
delivered  pursuant to this Agreement  shall be in the form set forth as Exhibit
A, attached  hereto and made a part hereof,  with such  appropriate  insertions,
omissions,  substitutions  and other variations as required or permitted by this
Agreement.


<PAGE>


     3. Exercise of Warrants.

          3.1 Cash Exercise.  The Warrants  initially are exercisable at a price
of $0.625 per Share, payable in cash or by check to the order of the Company, or
any combination of cash or check, subject to adjustment as provided in Article 8
hereof.  Upon  surrender  of the Warrant  Certificate  with the annexed  Form of
Election to Purchase duly executed,  together with payment of the Exercise Price
(as hereinafter  defined) for the Shares purchased,  at the Company's  principal
offices (presently located at 4110 N. Freeway Blvd.,  Sacramento,  CA 95834) the
registered  holder of a Warrant  Certificate  ("Holder" or  "Holders")  shall be
entitled to receive a certificate or  certificates  for the Shares so purchased.
The purchase rights  represented by each Warrant  Certificate are exercisable at
the option of the Holder thereof,  in whole or in part (but not as to fractional
shares of the Common  Stock).  In the case of the  purchase of less than all the
Shares purchasable under any Warrant Certificate,  the Company shall cancel said
Warrant  Certificate upon the surrender  thereof and shall execute and deliver a
new Warrant  Certificate of like tenor for the balance of the Shares purchasable
thereunder.


          3.2 Cashless  Exercise.  At any time during the Warrant Exercise Term,
the Holder may, at its option,  exchange all or part of the Warrants (a "Warrant
Exchange"), into the number of Shares determined in accordance with this Section
3.2, by  surrendering  his Warrant  Certificate  at the principal  office of the
Company or at the office of its transfer agent,  accompanied by a notice stating
such  holder's  intent  to  effect  such  exchange,  the  number of Shares to be
exchanged and the date on which the Holder  requests that such Warrant  Exchange
occur (the "Notice of Exchange").  The Warrant  Exchange shall take place on the
date  specified in the Notice of Exchange  or, if later,  the date the Notice of
Exchange is received by the Company (the "Exchange Date").  Certificates for the
Shares issuable upon such Warrant Exchange and, if applicable,  a new warrant or
warrants of like tenor evidencing the balance of the Shares remaining subject to
the  Warrants,  shall be issued as of the  Exchange  Date and  delivered  to the
Holder within seven (7) days following the Exchange Date. In connection with any
Warrant Exchange, the Warrant Certificate  surrendered shall represent the right
to subscribe  for and acquire the number of Shares  (rounded to the next highest
integer) equal to (i) the number of Shares specified by the Holder in its Notice
of Exchange  (the "Total  Number")  less (ii) the number of Shares  equal to the
quotient obtained by dividing (A) the product of the Total Number and the

                                       -2-





<PAGE>


existing Exercise Price (as hereinafter defined) by (B) the current market value
of a share of Common Stock.


     4. Issuance of Certificates.

     Upon the exercise of the  Warrants,  the issuance of  certificates  for the
Shares shall be made  forthwith  (and in any event within  three  business  days
thereafter) without charge to the Holder thereof including,  without limitation,
any tax which may be  payable  in  respect  of the  issuance  thereof,  and such
certificates  shall (subject to the provisions of Article 5 hereof) be issued in
the name of,  or in such  names  as may be  directed  by,  the  Holder  thereof;
provided,  however,  that the Company shall not be required to pay any tax which
may be payable in respect of any transfer  involved in the issuance and delivery
of any such certificates in a name other than that of the Holder and the Company
shall not be required to issue or deliver such certificates  unless or until the
person or persons requesting the issuance thereof shall have paid to the Company
the  amount of such tax or shall have  established  to the  satisfaction  of the
Company that such tax has been paid.

     The Warrant Certificates and the certificates representing the Shares shall
be executed on behalf of the Company by the manual or facsimile signature of the
present or any future  Chairman or Vice  Chairman of the Board of  Directors  or
Chief  Executive  Officer,  President or Vice President of the Company under its
corporate  seal  reproduced  thereon,  attested  to by the  manual or  facsimile
signature of the present or any future  Secretary or Assistant  Secretary of the
Company.  Warrant  Certificates  shall be dated  the  date of  execution  by the
Company upon initial issuance, division, exchange, substitution or transfer.

     The Warrant Certificates and, upon exercise of the Warrants,  in part or in
whole,  certificates  representing the Shares shall bear a legend  substantially
similar to the following:

     "The securities  represented by this  certificate  have not been registered
     under the  Securities  Act of 1933, as amended (the "Act"),  and may not be
     offered or sold except (i) pursuant to an effective  registration statement
     under the Act,  (ii) to the extent  applicable,  pursuant to Rule 144 under
     the Act (or any similar rule under such Act relating to the  disposition of
     securities),  or (iii) upon the delivery by the holder to the Company of an
     opinion of  counsel,  reasonably  satisfactory  to counsel to the  Company,
     stating that an

                                       -3-



<PAGE>



          exemption from registration under such Act is available."


     5. Investment Restriction.

     The Holder of a Warrant Certificate,  by its acceptance thereof,  covenants
and agrees that the Warrants are being  acquired as an investment and not with a
view to the distribution thereof.


     6. Price.

          6.1 Initial and Adjusted  Exercise Price.  The initial exercise prices
of each Warrant shall be $0.625 per Share. The adjusted  exercise price shall be
the price which shall result from time to time from any and all  adjustments  of
the  initial  exercise  price in  accordance  with the  provisions  of Article 8
hereof.


          6.2 Exercise  Price.  The term "Exercise  Price" herein shall mean the
initial  exercise  price or the  adjusted  exercise  price,  depending  upon the
context.


     7. Registration Rights.


          7.1  Registration  Under the  Securities Act of 1933. The Warrants and
the Shares have not been  registered for purposes of public  distribution  under
the Securities Act of 1933, as amended ("the Act").


          7.2  Registrable  Securities.  As used  herein  the term  "Registrable
Security" means each of the Warrants,  the Shares and any shares of Common Stock
issued  upon any  stock  split or stock  dividend  in  respect  of such  Shares;
provided,  however,  that with respect to any particular  Registrable  Security,
such security  shall cease to be a Registrable  Security when, as of the date of
determination,  (i) it has been effectively  registered under the Securities Act
and disposed of pursuant thereto,  (ii) registration under the Securities Act is
no longer  required for the immediate  public  distribution  of such security or
(iii) it has ceased to be outstanding.  The term "Registrable  Securities" means
any and/or all of the securities  falling  within the foregoing  definition of a
"Registrable   Security."   In  the   event  of  any   merger,   reorganization,
consolidation, recapitalization or

                                       -4-


<PAGE>


other change in corporate  structure affecting the Common Stock, such adjustment
shall be made in the definition of  "Registrable  Security" as is appropriate in
order to prevent any dilution or enlargement  of the rights granted  pursuant to
this Article 7.


          7.3  Piggyback  Registration.  If, at any time  during the seven years
following the date of this Agreement,  the Company  proposes to prepare and file
any registration statement or post-effective  amendments thereto covering equity
or debt securities of the Company, or any such securities of the Company held by
its  shareholders  (in any such case,  other than in  connection  with a merger,
acquisition  or pursuant to Form S-8 or successor  form),  (for purposes of this
Article 7,  collectively,  a  "Registration  Statement"),  it will give  written
notice of its intention to do so by registered mail ("Notice"),  at least thirty
(30) business days prior to the filing of each such Registration  Statement,  to
all holders of the  Registrable  Securities.  Upon the written request of such a
holder (a  "Requesting  Holder"),  made within  twenty (20)  business days after
receipt of the Notice,  that the Company include any of the Requesting  Holder's
Registrable  Securities  in the  proposed  Registration  Statement,  the Company
shall,  as to each such  Requesting  Holder,  use its best efforts to effect the
registration under the Securities Act of the Registrable Securities which it has
been so requested to register ("Piggyback Registration"),  at the Company's sole
cost and expense and at no cost or expense to the Requesting Holders.



          7.4 Demand Registration.

               (a) At any time during the Warrant  Exercise  Term, any "Majority
Holder"  (as such term is defined in Section  7.4(d)  below) of the  Registrable
Securities  shall have the right  (which  right is in addition to the  piggyback
registration  rights  provided  for under  Section 7.3 hereof),  exercisable  by
written notice to the Company (the "Demand Registration  Request"),  to have the
Company  prepare  and file with the  Securities  and  Exchange  Commission  (the
"Commission"),  on one occasion,  at the sole expense of the Company (other than
the pro rata portion of  underwriting  discounts,  if any,  attributable  to the
Holder's  Registrable  Securities  and the  expenses  of  Holder's  counsel  and
advisors),  a  Registration  Statement  and such other  documents,  including  a
prospectus,  as may be necessary (in the opinion of both counsel for the Company
and counsel for such Majority Holder), in order to comply with the provisions of
the  Act,  so as to  permit  a  public  offering  and  sale  of the  Registrable
Securities until such time as (i) the sale of all Registrable  Securities by the
holders thereof or (ii) receipt by the holders

                                       -5-





<PAGE>



thereof of an opinion of Company's  counsel that the Registrable  Securities may
be immediately publicly sold without registration under the Securities Act.

               (b) The Company  covenants  and agrees to give written  notice of
any Demand  Registration  Request to all holders of the  Registrable  Securities
within ten (10) days from the date of the  Company's  receipt of any such Demand
Registration  Request.  After  receiving  notice from the Company as provided in
this Section 7.4(b),  holders of Registrable  Securities may request the Company
to include  their  Registrable  Securities in the  Registration  Statement to be
filed  pursuant  to Section  7.4(a)  hereof by  notifying  the  Company of their
decision to include such securities within ten (10) days of their receipt of the
Company's notice.

               (c) The term "Majority  Holder" as used in this Section 7.4 shall
mean any holder or any  combination  of holders of  Registrable  Securities,  if
included in such holders'  Registrable  Securities are that aggregate  number of
Shares  (including  Shares  already issued and Shares  issuable  pursuant to the
exercise  of  outstanding  Warrants)  as  would  constitute  a  majority  of the
aggregate number of Shares  (including Shares already issued and Shares issuable
pursuant  to  the  exercise  of  outstanding  Warrants)  included  in all of the
Registrable Securities.

          7.5 Covenants of the Company With Respect to Registration. The Company
covenants and agrees as follows:

               (a) In connection with any registration under Section 7.4 hereof,
the Company shall file the Registration  Statement as expeditiously as possible,
but in no event later than twenty (20)  business days  following  receipt of any
demand  therefor,  shall  use its best  efforts  to have  any such  Registration
Statements  declared  effective at the earliest possible time, and shall furnish
each  holder of  Registrable  Securities  such number of  prospectuses  as shall
reasonably  be  requested.  In connection  with the  obligations  of the Company
hereunder  to  register  a Holder's  Registrable  Securities,  the Holder  shall
furnish  the Company  such  information  concerning  the  Holder,  the  Holder's
Registrable  Securities  and the  terms  of the  offering  of  such  Registrable
Securities  by the  Holder as the  Company  may  reasonably  request in order to
comply with the provisions of the Act with resect to the Registration  Statement
to be filed.

               (b) Other than fees and disbursements of counsel acting on behalf
of the  holders  of  Registrable  Securities  and the pro  rata  portion  of the
underwriting discounts and

                                       -6-


<PAGE>


commissions,  if any, attributable to Registrable Securities,  the Company shall
pay all costs, fees and expenses in connection with all Registration  Statements
filed pursuant to Sections 7.3 and 7.4(a) hereof including,  without limitation,
the Company's legal and accounting fees,  printing  expenses,  and blue sky fees
and expenses.


               (c) The  Company  will  take all  necessary  action  which may be
required in qualifying or registering the Registrable  Securities  included in a
Registration  Statement  for offering and sale under the  securities or blue sky
laws of such states as are requested by the holders of such securities, provided
that the Company  shall not be obligated to execute or file any general  consent
to service of process  or to  qualify as a foreign  corporation  to do  business
under the laws of any such jurisdiction.


               (d) The Company  shall  indemnify  any holder of the  Registrable
Securities to be sold pursuant to any Registration Statement and any underwriter
or person deemed to be an underwriter under the Act and each person, if any, who
controls such holder or underwriter or person deemed to be an underwriter within
the meaning of Section 15 of the Act or Section 20(a) of the Securities Exchange
Act of 1934, as amended  ("Exchange  Act"), from and against any and all losses,
claims,  damages,  expenses and liabilities  (including all expenses  reasonably
incurred in investigating,  preparing or defending against any claim whatsoever)
caused by any untrue  statement of a material fact contained in the Registration
Statement,  any other registration statement filed by the Company under the Act,
any post-effective amendment to such registration statements,  or any prospectus
included  therein  required to be filed or furnished by reason of this Agreement
or caused by any omission or alleged  omission to state  therein a material fact
required to be stated  therein or necessary to make the  statements  therein not
misleading,  except  insofar  as  such  losses,  claims,  damages,  expenses  or
liabilities are caused by any such untrue  statement or alleged untrue statement
or omission or alleged omission based upon information  furnished or required to
be  furnished in writing to the company by the Holder or  underwriter  expressly
for use therein;  which  indemnification  shall include each person, if any, who
controls any such Holder or  underwriter  within the meaning of the Act and each
officer, director,  employee and agent of such Holder or underwriter;  provided,
however,  that the Company  shall not be obligated to so indemnify the Holder or
any such  underwriter  or other  person  referred to above  unless the Holder or
underwriter  or  other  person,  as the case  may be,  shall  at the  same  time
indemnify the Company, its directors, each officer signing the

                                       -7-


<PAGE>


registration  statement and each person, if any, who controls the Company within
the meaning of the Act,  from and against any and all losses,  claims,  damages,
expenses  and  liabilities  caused by any untrue  statement  or  alleged  untrue
statement  of a material  fact  contained  in the  registration  Statement,  any
registration  statement or any  prospectus  required to be filed or furnished by
reason of this  Agreement or caused by any omission to state  therein a material
fact required to be stated therein or necessary to make the  statements  therein
not misleading, insofar as such losses, claims, damages, expenses or liabilities
are caused by any untrue statement or alleged untrue statement or omission based
upon  information  furnished  in  writing  to  the  Company  by  the  Holder  or
underwriter  expressly for use therein,  and provided,  further that the holder,
each person,  if any, who controls the holder within the meaning of the Act, and
each of the  Holder's  directors,  officers,  employees  and agents shall not be
obligated  to  indemnify  any  indemnified  person  pursuant  to  the  foregoing
indemnity, or to make any contribution pursuant to subparagraph 7.5(f) below, in
an amount in excess of the net proceeds  received by such holder with respect to
the sale of Registrable Securities.


               (e) Promptly after receipt of notice of the  commencement  of any
action in respect of which  indemnity  may be sought  against  any  indemnifying
party under this Section 7.5, the indemnified party will notify the indemnifying
party in writing of the commencement  thereof,  and the indemnifying party will,
subject to the provisions  hereinafter stated, assume the defense of such action
(including  the  employment  of counsel  reasonably  subject  to the  provisions
hereinafter stated,  assume the defense of such action (including the employment
of counsel  reasonably  satisfactory to the indemnified party and the payment of
expenses)  insofar as such action relates to an alleged  liability in respect of
which indemnity may be sought against the indemnifying  party. After notice from
the  indemnifying  party of its  election to assume the defense of such claim or
action,  the  indemnifying  party  shall no longer by liable to the  indemnified
party  under  this  Section  7.5 for any  legal or other  expenses  subsequently
incurred by the  indemnified  party in connection with the defense thereof other
than  reasonable  costs of  investigation;  provided,  however,  that if, in the
written opinion of counsel to the indemnified party or parties,  it is advisable
for the indemnified party or parties,  it is advisable for the indemnified party
or parties to be  represented  by separate  counsel,  the  indemnified  party or
parties  shall  have the  right to  employ a single  counsel  to  represent  the
indemnified  parties who may be subject to liability arising out of any claim in
respect of which  indemnity  may be sought by the  indemnified  parties  thereof
against the indemnifying party, in which event the reasonable

                                       -8-


<PAGE>


fees and expenses of such separate  counsel  shall be borne by the  indemnifying
party. Any party against whom  indemnification  may be sought under this Section
7.5  shall not be liable  to  indemnify  any  person  that  might  otherwise  be
indemnified  pursuant hereto for any settlement of any action  effected  without
such  indemnifying  party's  consent,  which consent  shall not be  unreasonably
withheld.


               (f) If for any reason the  indemnification  provided  for in this
Section 7.5 is held by a court of competent jurisdiction to be unavailable to an
indemnified party with respect to any loss, claim, damage,  expense or liability
referred to therein,  then the indemnifying  party, in lieu of indemnifying such
indemnified party thereunder,  shall contribute to the amount paid or payable by
the  indemnified  party as a result of such  loss,  claim,  damage,  expense  or
liability in such  proportion as is appropriate to reflect not only the relative
benefits received by the indemnified party and the indemnifying  party, but also
the relative fault of the indemnified party and the indemnifying  party, as well
as any other relevant equitable considerations.


               (g) Nothing  contained  in this  Agreement  shall be construed as
requiring any Holder to exercise his Warrants prior to the initial filing of any
Registration Statement or the effectiveness thereof.


     8.  Adjustments of Exercise Price and Number of Shares.  

          8.1 Computation of Adjusted Price. Except as hereinafter  provided, in
case the  Company  shall at any time  after  the date  hereof  issue or sell any
shares of Common Stock (other than the issuances or sales referred to in Section
8.6  hereof),  including  shares held in the  Company's  treasury  and shares of
Common  Stock  issued upon the  exercise of any  options,  rights or warrants to
subscribe  for shares of Common  Stock  (other  than the  issuances  or sales of
Common Stock  pursuant to rights to subscribe for such Common Stock  distributed
to all the  shareholders  of the Company  and  Holders of  Warrants  pursuant to
Section  8.8  hereof)  and  shares of Common  Stock  issued  upon the  direct or
indirect  conversion or exchange of securities for shares of Common Stock, for a
consideration   per  share  less  than  either  the  Exercise  Price  in  effect
immediately  prior to the issuance or sale of such shares or the "Market  Price"
(as  defined in Section  8.1(vi)  hereof)  per share of Common  Stock or without
consideration,  then  forthwith  upon such issuance or sale,  the Exercise Price
shall (until another such issuance or sale), be reduced to the price (calculated
to the nearest full cent) equal

                                       -9-


<PAGE>


to the  quotient  derived by dividing  (A) an amount equal to the sum of (X) the
product  of  (a)  the  total  number  of  shares  of  Common  Stock  outstanding
immediately  prior to such issuance or sale,  multiplied by (b) the lower of (i)
the Exercise Price in effect  immediately prior to such issuance or sale or (ii)
the "Market  Price" (as defined in  subsection  (vi) of this Section 8.1 hereof)
per share of Common Stock on the date immediately  prior to the issuance or sale
of such shares,  plus, (Y) the aggregate of the amount of all consideration,  if
any, received by the Company upon such issuance or sale, by (B) the total number
of shares of Common Stock  outstanding  immediately after such issuance or sale;
provided,  however,  that in no event  shall  the  Exercise  Price  be  adjusted
pursuant to this  computation  to an amount in excess of the  Exercise  Price in
effect  immediately  prior  to  such  computation,  except  in  the  case  of  a
combination  of outstanding  shares of Common Stock,  as provided by Section 8.3
hereof.

     For the  purposes of any  computation  to be made in  accordance  with this
Section 8.1, the following provisions shall be applicable:

                    (i) In case of the  issuance  or sale of  shares  of  Common
Stock for a consideration  part or all of which shall be cash, the amount of the
cash consideration therefor shall be deemed to be the amount of cash received by
the Company  for such  shares (or, if shares of Common  Stock are offered by the
Company for subscription,  the subscription  price, or, if such securities shall
be sold to underwriters  or dealers for public  offering  without a subscription
offering,  the initial public  offering  price) before  deducting  therefrom any
compensation  paid or  discount  allowed in the sale,  underwriting  or purchase
thereof by underwriters or dealers or others performing similar services, or any
expenses incurred in connection therewith.


                    (ii) In case of the  issuance or sale  (otherwise  than as a
dividend or other  distribution on any stock of the Company) of shares of Common
Stock for a  consideration  part or all of which  shall be other than cash,  the
amount of the  consideration  therefor other than cash shall be deemed to be the
value  of such  consideration  as  determined  in good  faith  by the  Board  of
Directors of the Company.


                    (iii) Shares of Common Stock  issuable by way of dividend or
other  distribution  on any  stock of the  Company  shall be deemed to have been
issued immediately after the opening of business on the day following the record
date for the determination of shareholders entitled to receive such dividend

                                      -10-


<PAGE>


or  other  distribution  and  shall  be  deemed  to  have  been  issued  without
consideration.


                    (iv) The reclassification of securities of the Company other
than shares of Common  Stock into  securities  including  shares of Common Stock
shall be deemed to involve the  issuance  of such  shares of Common  Stock for a
consideration  other than cash immediately prior to the close of business on the
date fixed for the  determination  of security  holders entitled to receive such
shares,  and the value of the  consideration  allocable to such shares of Common
Stock shall be determined as provided in subsection (ii) of this Section 8.1.


                    (v) The  number of  shares  of Common  Stock at any one time
outstanding shall include the aggregate number of shares issued or issuable upon
the exercise of options, rights, warrants and upon the conversion or exchange of
convertible or exchangeable securities.


                    (vi) As used herein,  the phrase  "Market Price" at any date
shall be deemed to be the last reported sale price, or, in case no such reported
sale takes place on such day, the average of the last  reported  sale prices for
the last three  trading  days,  in either  case as  officially  reported  by the
principal securities exchange on which the Common Stock is listed or admitted to
trading or as reported in the NASDAQ National  Market System,  or, if the Common
Stock is not listed or admitted to trading on any national  securities  exchange
or quoted  on the  NASDAQ  National  Market  System,  the  closing  bid price as
furnished by the National Association of Securities Dealers, Inc. through NASDAQ
or similar organization if NASDAQ is no longer reporting such information, or if
the  Common  Stock is not  quoted on  NASDAQ,  as  determined  in good  faith by
resolution  of  the  Board  of  Directors  of the  Company,  based  on the  best
information available to it for the two days immediately preceding such issuance
or sale and the day of such issuance or sale.


          8.2  Options,   Rights,  Warrants  and  Convertible  and  Exchangeable
Securities.  Except in the case of the Company  issuing  rights to subscribe for
shares of Common Stock  distributed to all the  shareholders  of the Company and
Holders of Warrants  pursuant to Section 8.8 hereof, if the Company shall at any
time after the date hereof issue  options,  rights or warrants to subscribe  for
shares of Common Stock, or issue any securities convertible into or exchangeable
for shares of Common Stock, (i) for a consideration  per share less than (a) the
Exercise Price in

                                      -11-


<PAGE>


effect immediately prior to the issuance of such options, rights or warrants, or
such  convertible or exchangeable  securities,  or (b) the Market Price, or (ii)
without  consideration,  the Exercise Price in effect  immediately  prior to the
issuance  of  such  options,   rights  or  warrants,   or  such  convertible  or
exchangeable  securities,  as the  case  may be,  shall  be  reduced  to a price
determined by making a computation in accordance  with the provisions of Section
8.1 hereof, provided that:


               (a) The aggregate  maximum  number of shares of Common Stock,  as
the case may be, issuable under all the outstanding options,  rights or warrants
shall be deemed to be issued  and  outstanding  at the time all the  outstanding
options,  rights or warrants were issued,  and for a consideration  equal to the
minimum purchase price per share provided for in the options, rights or warrants
at the time of issuance,  plus the consideration  (determined in the same manner
as consideration  received on the issue or sale of shares in accordance with the
terms of the Warrants),  if any, received by the Company for the options, rights
or  warrants,  and if no minimum  price is  provided in the  options,  rights or
warrants, then the consideration shall be equal to zero; provided, however, that
upon the expiration or other termination of the options,  rights or warrants, if
any thereof shall not have been exercised,  the number of shares of Common Stock
deemed to be issued and outstanding pursuant to this subsection (a) (and for the
purposes  of  subsection  (v) of Section  8.1  hereof)  shall be reduced by such
number of shares as to which options,  warrants and/or rights shall have expired
or terminated  unexercised,  and such number of shares shall no longer be deemed
to be issued  and  outstanding,  and the  Exercise  Price  then in effect  shall
forthwith be readjusted and thereafter be the price which it would have been had
adjustment been made on the basis of the issuance only of shares actually issued
or issuable upon the exercise of those  options,  rights or warrants as to which
the exercise rights shall not have expired or terminated unexercised.


               (b) The  aggregate  maximum  number of  shares  of  Common  Stock
issuable  upon  conversion  or  exchange  of  any  convertible  or  exchangeable
securities  shall be deemed to be issued and outstanding at the time of issuance
of  such  securities,  and  for  a  consideration  equal  to  the  consideration
(determined in the same manner as consideration received on the issue or sale of
shares of Common Stock in accordance with the terms of the Warrants) received by
the  Company  for such  securities,  plus  the  minimum  consideration,  if any,
receivable  by the Company upon the  conversion or exchange  thereof;  provided,
however,  that upon the  termination  of the right to convert or  exchange  such
convertible or exchangeable securities (whether by reason of redemption


                                      -12-


<PAGE>


or otherwise), the number of shares deemed to be issued and outstanding pursuant
to this  subsection  (b) (and for the purpose of  subsection  (v) of Section 8.1
hereof) shall be reduced by such number of shares as to which the  conversion or
exchange rights shall have expired or terminated unexercised, and such number of
shares shall no longer be deemed to be issued and  outstanding  and the Exercise
Price then in effect shall  forthwith be readjusted  and thereafter be the price
which it would have been had  adjustment  been made on the basis of the issuance
only of the shares  actually  issued or issuable upon the conversion or exchange
of those  convertible or  exchangeable  securities as to which the conversion or
exchange rights shall not have expired or terminated unexercised.

               (c) If any change shall occur in the price per share provided for
in any of the options,  rights or warrants referred to in subsection (a) of this
Section  8.2, or in the price per share at which the  securities  referred to in
subsection (b) of this Section 8.2 are convertible or exchangeable, the options,
rights or warrants or conversion or exchange  rights,  as the case may be, shall
be deemed to have  expired  or  terminated  on the date when such  price  change
became  effective in respect of shares not  theretofore  issued  pursuant to the
exercise or conversion or exchange  thereof,  and the Company shall be deemed to
have issued upon such date new  options,  rights or warrants or  convertible  or
exchangeable  securities  at the new price in  respect  of the  number of shares
issuable upon the exercise of such options, rights or warrants or the conversion
or exchange of such convertible or exchangeable securities.

          8.3 Subdivision and Combination. In case the Company shall at any time
subdivide or combine the outstanding  shares of Common Stock, the Exercise Price
shall  forthwith  be  proportionately  decreased in the case of  subdivision  or
increased in the case of combination.

          8.4  Adjustment  in Number of  Shares.  Upon  each  adjustment  of the
Exercise  Price  pursuant  to the  provisions  of this  Article 8, the number of
Shares  issuable  upon the  exercise  of each  Warrant  shall be adjusted to the
nearest full Share by multiplying a number equal to the Exercise Price in effect
immediately  prior to such  adjustment  by the  number of Shares  issuable  upon
exercise of the Warrants  immediately  prior to such adjustment and dividing the
product so obtained by the adjusted Exercise Price.

          8.5  Reclassification,  Consolidation,  Merger,  etc.  In  case of any
reclassification or change of the outstanding shares of Common Stock (other than
a change in par value to no par value,  or from no par value to par value, or as
a result of a

                                      -13-


<PAGE>


subdivision or combination),  or in the case of any consolidation of the Company
with,  or  merger  of  the  Company  into,  another  corporation  (other  than a
consolidation  or merger in which the Company is the surviving  corporation  and
which  does not  result in any  reclassification  or  change of the  outstanding
shares  of  Common  Stock,  except a  change  as a result  of a  subdivision  or
combination of such shares or a change in par value,  as  aforesaid),  or in the
case of a sale or  conveyance  to another  corporation  of the  property  of the
Company as an entirety,  the Holders shall thereafter have the right to purchase
the kind and  number  of  shares of stock  and  other  securities  and  property
receivable upon such reclassification,  change,  consolidation,  merger, sale or
conveyance  as if the  Holders  were the  owners of the  shares of Common  Stock
underlying the Warrants immediately prior to any such events at a price equal to
the product of (x) the number of shares  issuable  upon exercise of the Warrants
and (y) the Exercise  Price in effect  immediately  prior to the record date for
such reclassification,  change, consolidation,  merger, sale or conveyance as if
such Holders had exercised the Warrants.


          8.6 No Adjustment of Exercise Price in Certain Cases. No adjustment of
the Exercise Price shall be made:

               (a) Upon the  issuance or sale of shares of Common Stock upon the
          exercise of the Warrants;

               (b) Upon  (i) the  issuance  of  options  pursuant  to any of the
          Company's  employee stock option plans in effect on the date hereof or
          any  employee  stock  option  plan  adopted  after the date  hereof by
          stockholders of the Company the issuance or sale by the Company of any
          shares of Common Stock  pursuant to the exercise of any such  options,
          or (ii) the  issuance  or sale by the  Company of any shares of Common
          Stock  pursuant to the exercise of any options or warrants  previously
          issued and outstanding on the date hereof;

               (c) Upon  issuance  of any  shares  of Common  Stock  sold in the
          Company's  offerings  of an  aggregate  of up to  4,000,000  shares of
          Common  Stock  being  conducted  pursuant  to the  Company's  Offering
          Memoranda dated April 19, 1995 and April 21, 1995, respectively; or

               (d) Upon the issuance of any shares of Common Stock in connection
          with the Company's merger with AccuMed, Inc.


                                      -14-


<PAGE>


          8.7  Dividends  and Other  Distributions  with Respect to  Outstanding
Securities.  In the  event  that the  Company  shall  at any  time  prior to the
exercise of all Warrants  declare a dividend  (other than a dividend  consisting
solely of shares of Common Stock or a cash dividend or distribution  payable out
of current or retained earnings) or otherwise distribute to its shareholders any
monies, assets, property,  rights, evidences of indebtedness,  securities (other
than shares of Common Stock), whether issued by the Company or by another person
or entity, or any other thing of value, the Holder or Holders of the unexercised
Warrants shall thereafter be entitled, in addition to the shares of Common Stock
or other securities  receivable upon the exercise thereof, to receive,  upon the
exercise of such Warrants, the same monies, property,  assets, rights, evidences
of  indebtedness,  securities  or any other  thing of value that they would have
been  entitled to receive at the time of such dividend or  distribution.  At the
time of any such dividend or  distribution,  the Company shall make  appropriate
reserves to ensure the timely  performance of the provisions of this  Subsection
8.7.


          8.8   Subscription   Rights  for  Shares  of  Common  Stock  or  Other
Securities.  In the case the Company or an affiliate of the Company shall at any
time after the date hereof and prior to the exercise of all the  Warrants  issue
any rights to subscribe  for shares of Common Stock or any other  securities  of
the Company or of such  affiliate to all the  shareholders  of the Company,  the
Holders of the unexercised Warrants shall be entitled, in addition to the shares
of  Common  Stock or  other  securities  receivable  upon  the  exercise  of the
Warrants,  to receive such rights at the time such rights are distributed to the
other shareholders of the Company.


     9. Exchange and Replacement of Warrant Certificates.

     Each  Warrant  Certificate  is  exchangeable  without  expense,   upon  the
surrender hereof by the registered  Holder at the principal  executive office of
the Company,  for a new Warrant  Certificate of like tenor and date representing
in the  aggregate  the  right to  purchase  the same  number  of  Shares in such
denominations  as shall be designated by the Holder  thereof at the time of such
surrender.

     Upon receipt by the Company of evidence  reasonably  satisfactory  to it of
the loss, theft,  destruction or mutilation of any Warrant Certificate,  and, in
case of  loss,  theft  or  destruction,  of  indemnity  or  security  reasonably
satisfactory to it, and reimbursement to the Company of all reasonable expenses

                                      -15-


<PAGE>


incidental  thereto,  and upon surrender and  cancellation  of the Warrants,  if
mutilated,  the Company will make and deliver a new Warrant  Certificate of like
tenor, in lieu thereof.


     10. Elimination of Fractional Interests.

     The  Company  shall  not be  required  to issue  certificates  representing
fractions  of shares of Common Stock and shall not be required to issue scrip or
pay cash in lieu of  fractional  interests,  it being the intent of the  parties
that all fractional interests shall be eliminated by rounding any fraction up to
the nearest whole number of shares of Common Stock.

     11. Reservation and Listing of Securities.

     The  Company  shall at all  times  reserve  and keep  available  out of its
authorized  shares of Common Stock,  solely for the purpose of issuance upon the
exercise  of the  Warrants,  such  number of shares of Common  Stock as shall be
issuable upon the exercise thereof.  The Company covenants and agrees that, upon
exercise of the Warrants and payment of the Exercise Price therefor,  all shares
of Common Stock  issuable upon such exercise  shall be duly and validly  issued,
fully  paid,  non-assessable  and not  subject to the  preemptive  rights of any
shareholder. As long as the Warrants shall be outstanding, the Company shall use
its best efforts to cause all shares of Common Stock  issuable upon the exercise
of the  Warrants to be listed on or quoted by NASDAQ or listed on such  national
securities exchanges as requested by Commonwealth.

     12. Notices to Warrant Holders.

     Nothing  contained in this Agreement  shall be construed as conferring upon
the Holder or Holders the right to vote or to consent or to receive  notice as a
shareholder  in respect of any  meetings  of  shareholders  for the  election of
directors  or  any  other  matter,  or as  having  any  rights  whatsoever  as a
shareholder of the Company.  If, however, at any time prior to the expiration of
the Warrants and their exercise, any of the following events shall occur:

               (a) the Company  shall take a record of the holders of its shares
          of  Common  Stock  for the  purpose  of  entitling  them to  receive a
          dividend or  distribution  payable  otherwise  than in cash, or a cash
          dividend  or  distribution  payable  otherwise  than out of current or
          retained earnings, as indicated by the accounting

                                      -16-

<PAGE>


     treatment  of  such  dividend  or  distribution  on the  books  of the
     Company; or

               (b) the  Company  shall  offer to all the  holders  of its Common
          Stock  any  additional  shares  of  capital  stock of the  Company  or
          securities  convertible  into or  exchangeable  for  shares of capital
          stock of the  Company,  or any option,  right or warrant to  subscribe
          therefor; or

               (c) a  dissolution,  liquidation  or  winding  up of the  Company
          (other than in connection with a consolidation or merger) or a sale of
          all or  substantially  all of its property,  assets and business as an
          entirety shall be proposed;

then, in any one or more of said events,  the Company shall give written  notice
of such  event at least  fifteen  (15) days  prior to the date fixed as a record
date or the date of closing  the  transfer  books for the  determination  of the
shareholders   entitled  to  such   dividend,   distribution,   convertible   or
exchangeable securities or subscription rights, options or warrants, or entitled
to vote on such  proposed  dissolution,  liquidation,  winding up or sale.  Such
notice shall specify such record date or the date of closing the transfer books,
as the case may be.  Failure to give such notice or any defect therein shall not
affect the validity of any action taken in connection  with the  declaration  or
payment of any such dividend or distribution, or the issuance of any convertible
or exchangeable  securities or subscription rights,  options or warrants, or any
proposed dissolution, liquidation, winding up or sale.

     13. Notices.

     All notices, requests, consents and other communications hereunder shall be
in writing and shall be deemed to have been duly made when delivered,  or mailed
by registered or certified mail, return receipt requested:

               (a) If to a registered Holder of the Warrants,  to the address of
          such Holder as shown on the books of the Company; or

               (b) If to the  Company,  to the address set forth in Section 3 of
          this  Agreement or to such other  address as the Company may designate
          by notice to the Holders.

     14. Supplements and Amendments.

     The Company and Commonwealth may from time to time supplement or amend this
Agreement without the approval of any

                                      -17-


<PAGE>


Holders of Warrant  Certificates  in order to cure any ambiguity,  to correct or
supplement any provision contained herein which may be defective or inconsistent
with any provisions herein, or to make any other provisions in regard to matters
or  questions  arising  hereunder  which the Company and  Commonwealth  may deem
necessary  or  desirable  and which the  Company  and  Commonwealth  deem not to
adversely affect the interests of the Holders of Warrant Certificates.

     15. Successors.

     All the covenants and provisions of this Agreement by or for the benefit of
the Company and the Holders inure to the benefit of their respective  successors
and assigns hereunder.

     16. Termination.

     This Agreement shall terminate at the close of business on August 18, 2003.
Notwithstanding the foregoing, this Agreement will terminate on any earlier date
when all Warrants have been exercised and all the Shares  issuable upon exercise
of the  Warrants  have been resold to the public;  provided,  however,  that the
provisions  of Section 7.5 shall  survive  such  termination  until the close of
business on August 18, 2006.

     17. Governing Law.

     This  Agreement  and each Warrant  Certificate  issued  hereunder  shall be
deemed to be a contract made under the laws of the State of New York and for all
purposes shall be construed in accordance with the laws of said State.

     18. Benefits of This Agreement.

     Nothing  in this  Agreement  shall be  construed  to give to any  person or
corporation  other than the Company and  Commonwealth  and any other  registered
holder or holders of the Warrant Certificates,  Warrants or the Shares any legal
or equitable  right,  remedy or claim under this  Agreement;  and this Agreement
shall be for the sole and exclusive  benefit of the Company and Commonwealth and
any other holder or holders of the Warrant Certificates, Warrants or the Shares.


     19. Counterparts.

     This  Agreement may be executed in any number of  counterparts  and each of
such counterparts shall for all purposes

                                      -18-

<PAGE>


be deemed to be an original, and such counterparts shall together constitute but
one and the same instrument.

     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
duly executed, as of the day and year first above written.


[SEAL]                                      ALAMAR BIOSCIENCES, INC.


                                            By:____________________________
                                               Name:
                                               Title:
Attest:
__________________________


                                            COMMONWEALTH ASSOCIATES

                                            By: Commonwealth Associates
                                                Management Company, Inc.,
                                                General Partner


                                            By:_____________________________
                                               Name:
                                               Title:



                                      -19-


<PAGE>


THE WARRANTS  REPRESENTED BY THIS CERTIFICATE AND THE OTHER SECURITIES  ISSUABLE
UPON EXERCISE THEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED (THE "ACT"), AND MAY NOT BE OFFERED OR SOLD EXCEPT (i) PURSUANT TO AN
EFFECTIVE  REGISTRATION  STATEMENT UNDER THE ACT, (ii) TO THE EXTENT APPLICABLE,
PURSUANT TO RULE 144 UNDER SUCH ACT (OR ANY SIMILAR RULE UNDER SUCH ACT RELATING
TO THE DISPOSITION OF  SECURITIES),  OR (iii) UPON THE DELIVERY BY THE HOLDER TO
THE COMPANY OF AN OPINION OF COUNSEL, REASONABLY SATISFACTORY TO COUNSEL FOR THE
COMPANY,  STATING  THAT  AN  EXEMPTION  FROM  REGISTRATION  UNDER  SUCH  ACT  IS
AVAILABLE.

THE  TRANSFER OR EXCHANGE OF THE WARRANTS  REPRESENTED  BY THIS  CERTIFICATE  IS
RESTRICTED IN ACCORDANCE WITH THE WARRANT AGREEMENT REFERRED TO HEREIN.

                            EXERCISABLE ON OR BEFORE
                 5:00 P.M., NEW YORK CITY TIME, AUGUST 22, 2000

No. W-__                                                         41,300 Warrants
                               WARRANT CERTIFICATE

     This   Warrant   Certificate   certifies   that   Commonwealth   Associates
("Commonwealth")  or  registered  assigns,  is the  registered  holder of 41,300
Warrants to purchase,  at any time from August 22, 1995 until 5:00 P.M. New York
City  time on  August  22,  2000 (the  "Expiration  Date")  up to 41,300  shares
("Shares") of fully-paid and non-assessable  common stock, no par value ("Common
Stock"), of Alamar BioSciences,  Inc., a California corporation (the "Company"),
at the initial  exercise  price,  subject to adjustment  in certain  events (the
"Exercise  Price"),  of  $0.625  per  Share,  upon  surrender  of  this  Warrant
Certificate  and  payment  of the  Exercise  Price at an office or agency of the
Company,  but  subject to the  conditions  set forth  herein and in the  warrant
agreement dated as of August 22, 1995 between the Company and Commonwealth  (the
"Warrant  Agreement").  Payment of the Exercise Price may be made in cash, or by
check payable to the order of the Company, or any combination of cash or check.

     No Warrant may be  exercised  after 5:00 P.M.,  New York City time,  on the
Expiration Date, at which time all Warrants  evidenced hereby,  unless exercised
prior thereto, shall thereafter be void.

     The  Warrants  evidenced  by this  Warrant  Certificate  are part of a duly
authorized  issue of Warrants  issued pursuant to the Warrant  Agreement,  which
Warrant Agreement is hereby incorporated by reference in and made a part of this
instrument and is hereby referred to in a description of the rights,  limitation
of rights, obligations, duties and immunities thereunder of the


<PAGE>


Company and the holders (the words "holders" or "holder"  meaning the registered
holders or registered holder) of the Warrants.

     The Warrant Agreement  provides that upon the occurrence of certain events,
the Exercise Price and/or number of the Company's  securities issuable thereupon
may,  subject to certain  conditions,  be adjusted.  In such event,  the Company
will, at the request of the holder,  issue a new Warrant Certificate  evidencing
the  adjustment  in the Exercise  Price and the number and/or type of securities
issuable upon the exercise of the Warrants;  provided, however, that the failure
of the  Company  to issue  such new  Warrant  Certificates  shall not in any way
change, alter, or otherwise impair, the rights of the holder as set forth in the
Warrant Agreement.

     Upon  due  presentment  for   registration  of  transfer  of  this  Warrant
Certificate at an office or agency of the Company, a new Warrant  Certificate or
Warrant Certificates of like tenor and evidencing in the aggregate a like number
of Warrants  shall be issued to the  transferee(s)  in exchange for this Warrant
Certificate,  subject to the  limitations  provided  herein  and in the  Warrant
Agreement,  without any charge except for any tax, or other governmental  charge
imposed in connection therewith.

     Upon the  exercise  of less  than  all of the  Warrants  evidenced  by this
Certificate,  the  Company  shall  forthwith  issue to the  holder  hereof a new
Warrant Certificate representing such number of unexercised Warrants.

     The  Company  may deem and treat  the  registered  holder(s)  hereof as the
absolute owner(s) of this Warrant Certificate  (notwithstanding  any notation of
ownership  or other  writing  hereon  made by  anyone),  for the  purpose of any
exercise hereof,  and of any distribution to the holder(s)  hereof,  and for all
other  purposes,  and the  Company  shall not be  affected  by any notice to the
contrary.

     All terms used in this Warrant Certificate which are defined in the Warrant
Agreement shall have the meanings assigned to them in the Warrant Agreement.

     IN WITNESS WHEREOF,  the Company has caused this Warrant  Certificate to be
duly executed under its corporate seal.

Dated: August 22, 1995                        ALAMAR BIOSCIENCES, INC.

[SEAL]                                        By:_____________________________
                                                 Name:
                                                 Title:
Attest:
________________________


<PAGE>

                         [FORM OF ELECTION TO PURCHASE]

     The  undersigned   hereby   irrevocably   elects  to  exercise  the  right,
represented  by this  Warrant  Certificate,  to  purchase  _________  Shares and
herewith  tenders in payment for such  Shares in cash or a check  payable to the
order of Alamar  Biosciences,  Inc. in the amount of $______ , all in accordance
with the terms hereof.  The  undersigned  requests  that a certificate  for such
Shares  be  registered  in  the  name   of_______________  ,  whose  address  is
__________________,    and   that   such    Certificate    be    delivered    to
__________________, whose address is _____________.


Dated:                                   Signature:___________________________
                                         (Signature  must conform in
                                         all  respects  to  name  of
                                         holder as  specified on the
                                         face    of   the    Warrant
                                         Certificate.)

                        _________________________________

                        _________________________________
                        (Insert Social Security or Other
                          Identifying Number of Holder)


<PAGE>


                              [FORM OF ASSIGNMENT]

                (To be executed by the registered holder if such
                     holder desires to transfer the Warrant
                                  Certificate.)


     FOR VALUE RECEIVED__________________________________________

hereby sells, assigns and transfers unto

_____________________________________________________________________________
(Please print name and address of transferee)

this Warrant  Certificate,  together with all right, title and interest therein,
and does hereby irrevocably constitute and appoint _______________, Attorney, to
transfer  the  within  Warrant  Certificate  on the  books  of the  within-named
Company, with full power of substitution.


Dated:                                   Signature:___________________________

                                         (Signature must conform in all
                                         respects to name of holder as
                                         specified on the face of the
                                         Warrant Certificate)


________________________________

________________________________
(Insert Social Security or Other
Identifying Number of Assignee)







                     Exhibit Pursuant to Rule 13d-1(f)(1)
                  under the Securities Exchange Act of 1934


            Each of the  undersigned  agrees that the Schedule 13D to which this
agreement is attached as an Exhibit is filed on behalf of each of them  pursuant
to the above Rule.

Dated: as of October 7, 1996


            Commonwealth Associates
            By: Commonwealth Associates Management Company, Inc.,
                 its General Partner


            By:   /s/ Michael S. Falk
               ------------------------------------------
                      Michael S. Falk, President

            Commonwealth Associates Management Company, Inc.,


            By:   /s/ Michael S. Falk
               ------------------------------------------
                      Michael S. Falk, President

            By:   /s/ Michael S. Falk
               ------------------------------------------
                      Michael S. Falk



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