APHTON CORP
S-3/A, 1998-01-30
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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    As filed with the Securities and Exchange Commission on January 30, 1998
               Registration Nos. 33-77286, 333-00586 and 333-31217
 ------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                        ---------------------------------
                         POST-EFFECTIVE AMENDMENT NO. 1
                                   TO FORM S-3
                             REGISTRATION STATEMENTS
                                      Under
                           The Securities Act of 1933
                               -------------------
                               APHTON CORPORATION
             (Exact name of Registrant as specified in its charter)
                              ---------------------

       Delaware                                         95-3640931
- - ------------------------                     ----------------------------------
(State of Incorporation)                     (I.R.S. Employer Identification No.


                               80 S.W. 8th Street
                            Miami, Florida 33130-3047
   (Address, including zip code, of Registrant's principal executive offices)


                             -----------------------
                          The Corporation Trust Company
                            Corporation Trust Center
                               1209 Orange Street
                           Wilmington, Delaware 19801
                                 (302) 658-7581
(Name, address, and telephone number, including area code, of agent for service)
                             -----------------------
                                   Copies to:
                            Timothy B. Goodell, Esq.
                                  White & Case
                           1155 Avenue of the Americas
                            New York, New York 10036




<PAGE>




                                EXPLANATORY NOTE

          This  Post-Effective  Amendment  No. 1 to those  certain  Registration
Statements  on Form S-3 (File  Nos.  33-77286,  333-00586  and  333-31217)  (the
"Registration  Statements")  is  being  filed  pursuant  to Rule 414  under  the
Securities Act of 1933, as amended (the "1933 Act"),  by Aphton  Corporation,  a
Delaware  corporation  ("Aphton  Delaware"  or  the  "Company"),  which  is  the
successor to Aphton Corporation, a California corporation ("Aphton California"),
following a statutory  merger  effective on January 29, 1998 (the  "Merger") for
the purpose of changing Aphton California's state of incorporation. Prior to the
Merger,  Aphton Delaware had no assets or liabilities  other than nominal assets
or  liabilities.  In connection with the Merger,  Aphton  Delaware  succeeded by
operation of law to all of the assets and liabilities of Aphton California.  The
Merger was approved by the  shareholders  of Aphton  California at a meeting for
which  proxies  were  solicited  pursuant  to  Section  14(a) of the  Securities
Exchange Act of 1934, as amended (the "1934 Act").

          Except as modified by this Amendment,  Aphton  Delaware,  by virtue of
this  Amendment,  expressly  adopts  the  Registration  Statements  as  its  own
registration statements for all purposes of the 1933 Act and the 1934 Act.


                 PART II. INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 15.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

          Section  145 of the  Delaware  General  Corporation  Law (the  "DGCL")
permits the Company to indemnify its directors,  officers,  employees and agents
(each an "Insider")  against liability for each such Insider's acts taken in his
or her  capacity as an Insider in a civil  action,  suit or  proceeding  if such
actions were taken in good faith and in a manner  which the Insider  believed to
be in or not opposed to the best  interests  of the  Company,  and in a criminal
action,  suit or proceeding,  if the Insider had no reasonable  cause to believe
his or her conduct was unlawful, including under certain circumstances, suits by
or in the right of the Company for any expenses,  including attorneys' fees, and
for any  liabilities  which the Insider may have incurred in consequence of such
action,  suit or  proceeding  under  conditions  stated in said Section 145. The
Company's  Certificate  of  Incorporation  and By-Laws  provide that the Company
shall  indemnify its directors and officers to the fullest extent  authorized by
the  DGCL;   provided,   that  the   Company  may  modify  the  extent  of  such
indemnification  by  individual  contracts  with  its  directors  and  executive
officers,  and,  provided  further,  that the  Company  will not be  required to
indemnify  any director or  executive  officer in  connection  with a proceeding
initiated by such person, with certain exceptions.

          As permitted by Section  102(b)(7) of the DGCL,  Article  NINTH of the
Company's  Certificate of Incorporation  provides that a director of the Company
will not be personally  liable to the Company or its  stockholders  for monetary
damages for breach of fiduciary duty as a director, except for liability (i) for
any breach of the director's duty of loyalty to the Company or its stockholders,
(ii) for acts or  omissions  not in good  faith  or  which  involve  intentional
misconduct or a knowing  violation of law,  (iii) under Section 174 of the DGCL,
as amended,  which concerns unlawful  payments of dividends,  stock purchases or
redemption,  or (iv) for any  transaction  from  which the  director  derived an
improper personal benefit.

          The  Company's  Certificate  of  Incorporation  permits the Company to
secure insurance on behalf of any director, officer, employee or other agent for
any liability arising out of his or her actions in such capacity,  regardless of
whether the Company would have the power to indemnify  such person  against such
liability under the DGCL.
<PAGE>
ITEM 16.      EXHIBITS.

Exhibit
Number    Document


2.1       Agreement  and  Plan of  Merger  of  Aphton  Corporation,  a  Delaware
          corporation,  and Aphton Corporation, a California corporation,  dated
          as of January 29,  1998.  Incorporated  by reference to Exhibit 2.1 to
          the Company's Current Report on Form 8-K dated January 30, 1998.

3.1       Certificate of Incorporation of the Company. Incorporated by reference
          to  Exhibit  3.1 to the  Company's  Current  Report  on Form 8-K dated
          January 30, 1998.

3.2       By-laws of the  Company.  Incorporated  by reference to Exhibit 3.2 to
          the Company's Current Report on Form 8-K dated January 30, 1998.

23.1      Independent Auditor's Consent.

24.1      Power of Attorney.*

- - ---------------
*Previously filed.


<PAGE>
                                    SIGNATURES

          Pursuant  to the  requirements  of the  Securities  Act of  1933,  the
registrant certifies that it has reasonable grounds to believe that it meets all
of  the   requirements  for  filing  on  Form  S-3  and  has  duly  caused  this
Post-Effective  Amendment  No. 1 to the Form S-3  Registration  Statements to be
signed on its behalf by the undersigned,  thereunto duly authorized, in the City
of Miami, State of Florida, on this 30th day of January, 1998.

                                      APHTON CORPORATION


                                      By:/s/ Frederick W. Jacobs
                                         ------------------------------
                                         Frederick W. Jacobs
                                         Treasurer and Chief Accounting Officer



<PAGE>
                                  EXHIBIT INDEX



Exhibit
Number    Document


2.1       Agreement  and  Plan of  Merger  of  Aphton  Corporation,  a  Delaware
          corporation,  and Aphton Corporation, a California corporation,  dated
          as of January 29,  1998.  Incorporated  by reference to Exhibit 2.1 to
          the Company's Current Report on Form 8-K dated January 30, 1998.

3.1       Certificate of Incorporation of the Company. Incorporated by reference
          to  Exhibit  3.1 to the  Company's  Current  Report  on Form 8-K dated
          January 30, 1998.

3.2       By-laws of the  Company.  Incorporated  by reference to Exhibit 3.2 to
          the Company's Current Report on Form 8-K dated January 30, 1998.

23.1      Independent Auditor's Consent.

24.1      Power of Attorney.*

- - ---------------
**Previously filed.



                                                          EXHIBIT 23.1


                       CONSENT OF INDEPENDENT ACCOUNTANTS


          We  consent  to  the  continued  incorporation  by  reference  in  the
registration  statements of Aphton Corporation on Forms S-3 (File Nos. 33-77286,
333-00586,  and  33-31217)  of our  reports  on  our  audits  of  the  financial
statements of Aphton Corporation, which reports are included in Annual Report on
Form 10-K incorporated by reference in those registration statements,  which are
being  amended by the  post-effective  amendment to be filed on or about January
30, 1998.

                                           COOPERS & LYBRAND L.L.P.
                                           /s/ Coopers & Lybrand L.L.P.


Honolulu, Hawaii
January 30, 1998


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