APHTON CORP
S-3, EX-5.1, 2000-10-26
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                                                     EXHIBIT 5.1

                                White & Case LLP
                           1155 Avenue of the Americas
                            New York, New York 10036

October 26, 2000

Aphton Corporation
80 S.W. 8th Street
Miami, Florida  33130-3047

Dear Sirs:

     We have examined the Registration  Statement on Form S-3 (the "Registration
Statement") under the Securities Act of 1933, as amended (the "Securities Act"),
in the form in which it is to be filed by  Aphton  Corporation  (the  "Company")
with the Securities and Exchange  Commission (the  "Commission"),  in connection
with  the  sale  from  time to time by the  selling  stockholders  named  in the
Registration  Statement  (the  "Selling  Stockholders")  of 1,291,509  shares of
common stock, no par value, of the Company (the "Resale Shares").

     In connection with our opinion expressed below, we have examined  originals
or  copies  certified  to  our  satisfaction  of  such  agreements,   documents,
certificates and other statements of government officials and corporate officers
of the Company and such other papers as we have deemed relevant and necessary as
a basis for such opinion.  As to certain facts material to our opinion,  we have
relied,  to the extent that we deem such reliance proper,  upon  certificates of
public officials and of officers of the Company.  In rendering such opinion,  we
have  assumed  the  genuineness  of  all  signatures,  the  authenticity  of all
documents  submitted to us as originals and the conformity to authentic original
documents  of  all  documents  submitted  to  us  as  certified,   conformed  or
photostatic copies.

     Based upon and subject to the foregoing,  it is our opinion that the Resale
Shares have been validly issued and are fully paid and nonassessable.

     We consent to the filing of this opinion as an exhibit to the  Registration
Statement and to the reference to our firm  appearing  under the caption  "Legal
Matters" in the Prospectus forming part of the Registration Statement. In giving
this consent, we do not thereby admit that we are within the category of persons
whose consent is required under Section 7 of the Securities Act or the rules and
regulations of the Commission.

                                      Very truly yours,

                                      /s/  WHITE & CASE LLP


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