APHTON CORP
DEF 14A, 2000-05-31
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  May 29, 2000



Dear Shareholder:

The  Annual  Meeting  of  Shareholders  of  Aphton  Corporation  will be held on
Wednesday,  June 21, 2000, at 9:00 A.M. at the offices of White & Case,  located
at First Union Financial Center, 200 South Biscayne  Boulevard,  Miami,  Florida
33131-2352.

The Notice of Annual  Meeting and the Proxy  Statement  are  enclosed  herewith.
Shareholders  will be asked to elect two  directors  in one  class.  The Class 2
nominees are Nicholas  John Stathis and Georges Hibon whose term of office would
expire at the 2003  Annual  Meeting of  Shareholders.  Your  Board of  Directors
recommends that you vote "for" these nominees.

Please review the Proxy  Statement and at your earliest  convenience  sign, date
and return the enclosed  proxy card so that your shares will be  represented  at
the meeting. A prepaid return envelope is enclosed for this purpose.

Yours truly,
    /s/
Philip C. Gevas
Chairman, President and Chief Executive Officer

PCG/me
encl.













                                  May 29, 2000

                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS

                                  June 21, 2000

The  Annual  Meeting  of   Shareholders  of  Aphton   Corporation,   a  Delaware
corporation, will be held at the offices of White & Case, located at First Union
Financial Center, 200 South Biscayne Boulevard,  Miami,  Florida 33131-2352,  on
Wednesday, June 21, 2000, at 9:00 A.M. for the following purposes:

(1) To elect two  directors  in one class to hold  office  until the 2003 Annual
Meeting of Shareholders  and thereafter  until their successors are duly elected
and  qualified;

(2) To transact such other business as may properly come before the meeting.

On any  business  day from June 7, 2000 until  June 20,  2000,  during  ordinary
business  hours,  shareholders  may  examine  the list of  shareholders  for any
purpose germane to the meeting at the Office of the Company's attorneys, White &
Case, First Union Financial Center, 200 South Biscayne Boulevard, Miami, Florida
33131.

The Board of Directors  has fixed the close of business on Monday,  May 8, 2000,
as the record date for determination of shareholders entitled to be notified and
to vote at the Annual Meeting.

ALL STOCKHOLDERS ARE CORDIALLY  INVITED TO ATTEND THE ANNUAL MEETING.  TO ENSURE
YOUR  REPRESENTATION AT THE MEETING,  THE BOARD REQUESTS THAT YOU SIGN, DATE AND
RETURN THE ENCLOSED PROXY IN THE ACCOMPANYING SELF-ADDRESSED,  STAMPED ENVELOPE.
YOUR PROXY WILL NOT BE USED IF YOU ARE  PRESENT AT THE  MEETING AND WISH TO VOTE
YOUR SHARES PERSONALLY.

By Order of the Board of Directors
     /s/
Philip C. Gevas
Chairman, President and
Chief Executive Officer



                                PROXY STATEMENT
              ANNUAL MEETING OF SHAREHOLDERS OF APHTO CORPORATION
                                 June 21, 2000
                                  INTRODUCTION
This Proxy  Statement is being mailed on or about May 29, 2000, to  shareholders
of Aphton  Corporation  (the "Company") in connection  with the  solicitation of
Proxies by the  Company's  Board of Directors  for use at the  Company's  Annual
Meeting of  Shareholders to be held on June 21, 2000, for the purposes set forth
herein and in the  accompanying  Notice of Annual Meeting of  Shareholders.  The
accompanying  proxy, and all expenses  incident to the  solicitation,  are to be
paid by the Company.

The persons named in the  accompanying  proxy have advised the Company that they
intend to vote the  proxies  received  by them in their  discretion  for as many
director nominees as the votes represented by such proxies are entitled to elect
(see "Election of  Directors").  Any  shareholder may revoke his or her proxy at
any time prior to its use by filing with the  Secretary of the Company a written
notice of revocation or a duly executed proxy bearing a later date.'

Only  shareholders  of record at the close of business  on Monday,  May 8, 2000,
will be  entitled  to notice of and to vote at the  meeting or any  adjournments
thereof.  At such record date, the Company had  outstanding and entitled to vote
16,183,899  shares of common stock.  Each share of stock is entitled to one vote
on all matters.

                              ELECTION OF DIRECTORS

The  Company's  Board of Directors  presently  consists of five  directors.  The
persons who are elected  director will hold office until the 2003 Annual Meeting
of  Shareholders  and  thereafter  until their  successor is duly  elected,  and
qualified.

Set forth below is the names and principal  occupations of those persons who are
presently  directors  of the  Company,  and the  respective  number of shares of
voting stock of the Company beneficially owned, directly or indirectly,  by them
and by all  directors  and  officers as a group as of May 8, 2000,  according to
information  furnished to the Company by such persons. Mr. Georges Hibon and Mr.
Nicholas John Stathis are the Class 2 nominees for election.
<TABLE>
             <S>                        <C>        <C>                   <C>                  <C>

                                                                   Shares Beneficially
   Name and Principal Occupation                  Year First           Owned as of
                                        Age         Elected           May 19, 2000         Percent of Class
Philip C. Gevas, Class 3
Chairman, President and Chief
Executive Officer, Aphton                66           1981                 1,859,050              11.5
Corporation

William A. Hasler, Class 3               58           1991                    70,000              (1)
Co-Chief Executive Officer and
Vice-Chairman, Aphton Corporation

Robert S. Basso, Class 1                 55           1988                    30,166              (1)
President, Correspondent Services
Corporation

Geoorges Hibon, Class 2                  62           2000                         0              (1)
Former Chairman and Chief Executive
Officer, Pasteur Merieux Connaught, NA

Nicholas John Stathis, Class 2           76           1994                    50,000              (1)
Attorney

All Directors and Officers
as a group (12 persons)                                                     2,124,216            13.1
____________________________
(1)  Less than 1% of total outstanding shares.
</TABLE>

Mr.  Gevas has served the Company and  continues to serve in the  capacities  of
Chairman,  President and Chief Executive  Officer and has been a director of the
Company  since its  inception.  William A. Hasler was elected  Vice  Chairman in
October,  1996 and has been a director of the Company since  October,  1991. Mr.
Hasler was appointed  Co-Chief  Executive Officer of Aphton Corporation in July,
1998. Previously, he was the Dean of both the Graduate and Undergraduate Schools
of Business at the University of California, Berkeley since 1991. Prior thereto,
Mr. Hasler was Vice Chairman of KPMG Peat Marwick,  responsible  for  management
consulting  worldwide.  Mr. Hasler also is a director of Solectron  Corporation,
Walker  Interactive  Systems,  TCSI  Corporation,  Tenera,  Inc. and is a Public
Governor of the Pacific  Exchange.  Mr. Basso has been a director of the Company
since  February,  1988.  He has been  employed  in his present  capacities  with
Correspondent  Services Corporation since January, 1990. Prior thereto, for more
than ten years,  Mr.  Basso was  employed  by Merrill  Lynch as  President  of a
wholly-owned  subsidiary and in other executive management  capacities.  Georges
Hibon was elected a director in 2000.  During the  previous  ten years Mr. Hibon
served as the Chairman and Chief Executive Officer of Pasteur Merieux Connaught,
NA,  Chairman  of  Virogenetics,  and as the Senior  Vice  President  of Pasteur
Merieux  Connaught,  NA. Nicholas John Stathis,  Esq. has been a director of the
Company since January, 1994. Mr. Stathis is retired from the law firm of White &
Case,  where he was of counsel from 1989 to 1993.  Prior to that he was partner,
Botein, Hays & Sklar, from 1984 to 1989.

Directors do not receive any fees for services on the Board.  Board  members are
reimbursed for their expenses for each meeting attended.

If for any reason  either Mssrs.  Hibon or Stathis  should not be available as a
candidate  for  director,  an  event  that  the  Board  of  Directors  does  not
anticipate,  the persons  named in the  enclosed  proxy will vote for such other
candidate as may be nominated by the Board and discretionary  authority to do so
is included in the Proxy.
                  Committee Meetings of the Board of Directors

The Company's  Board of Directors held five general  meetings and four committee
meetings  during the year ended January 31, 2000. The Board of Directors has two
standing committees: an Audit Committee, consisting of Messrs. Basso (Chairman),
Hasler and Stathis;  and a Compensation  Committee,  consisting of Messrs. Basso
(Chairman) and Stathis.  The Audit Committee reviews the financial statements of
the  Company,   reviews  the  independent   accountants'  scope  of  engagement,
performance  and  fees  and  reviews  the  adequacy  of the  Company's  internal
financial  control  procedures.  This Committee held four meetings during fiscal
2000.  The   Compensation   Committee   reviews  and   recommends   remuneration
arrangements  for various key  executives.  This  Committee  held four  meetings
during fiscal 2000.  Each Committee  member  attended all of the meetings of the
Committee on which he was a member during fiscal 2000.
                        The Compensation Committee Report

The Compensation Committee of the Board approves compensation objectives, policy
and compensation for the Company's executive officers, including the individuals
named in the Summary Compensation table below.

The Compensation Committee is comprised of Messrs. Basso and Stathis.

The Compensation  Committee seeks to provide rewards which are closely linked to
Company and individual  performance  and ensure that  compensation is at a level
which  enables the Company to attract and retain the high  quality  employees it
needs. In addition,  the committee  considers  performance factors particular to
each  executive  officer,  such  as  the  performance  where  such  officer  had
responsibility and individual managerial accomplishments.

Compensation of the Chief Executive Officer

The Compensation  Committee believes that Mr. Gevas' total compensation as Chief
Executive  Officer  reflects his  performance  in meeting or exceeding the goals
established by the Committee.

In  determining  Mr.  Gevas'  total  compensation,  the  Compensation  Committee
considered  the  Company's   overall   performance  and  Mr.  Gevas'  individual
performance by the measures described above for determining  executive officers'
compensation. It also considered the compensation and company performance of the
chief executive officers of other leading  companies,  as well as incentives for
future performance.

The    Company's    performance    as   measured   in   the   context   of   the
biotechnology/biopharmaceutical  industry and Mr. Gevas' contributions  thereto,
both  management and  scientific,  have met or exceeded the Company  objectives.
This   performance   included  the  structuring  and  negotiation  with  another
significant pharmaceutical company for a strategic alliance. The following stock
price  performance  graph is provided as required by the Securities and Exchange
Commission.  The graph compares the Company's stock price  appreciation with the
stock price  appreciation of both the Nasdaq Composite Index and a peer group of
biotechnology/  biopharmaceutical  companies which, like Aphton,  had an initial
public offering (IPO) during 1991, and includes the measurement point as defined
and required by the SEC.

The foregoing report has been furnished by the Compensation Committee consisting
of Messrs. Basso (Chairman) and Stathis.

                         Stock Price Performance Graph

The following graph illustrates a comparison of the cumulative total stockholder
return  (change in stock  price) of  Aphton's  Common  Stock with the CRSP Total
Return Index for the Nasdaq Stock Market (the Nasdaq Composite Index) and a Peer
Group composed of other biotechnology/biopharmaceutical companies which had IPOs
during the same year as Aphton (and are still  publicly  traded).  The following
graph commences in 1991, with a $100 investment in the Company, the Nasdaq index
and the Peer Group (whose  composition  reflects the average of the share values
as reported on the dates shown).  Five year graphic  comparisons are required by
the  Securities  and  Exchange   Commission  (SEC).  An  additional   comparison
commencing with a $100 investment in the Company,  the Nasdaq index and the Peer
Group at the required  measurement  date of January 31, 1995 is included.  These
graphs  are not  intended  to  forecast  or be  indicative  of  possible  future
performances of the Company's Common Stock.

Aphton believes that the best date for Aphton  shareholders to begin comparisons
is the first date of trading in the Company's  stock.  Aphton also believes that
the  best   peer   group  for   graphic   comparisons   is  the   biotechnology/
biopharmaceutical  companies  which,  like  Aphton,  had IPOs  during  1991 (the
initial date of investments of $100).  However,  Aphton is not aware of any such
published  "third-party" index or listing;  thus, the Peer Group names and graph
was prepared by the Company based on data provided to Aphton by Nasdaq. The Peer
Group is  composed of Cygnus  Therapeutic  Systems,  Regeneron  Pharmaceuticals,
Cephalon Inc., Medimmune Inc., Isis Pharmaceuticals,  ImmuLogic  Pharmaceutical,
ICOS Corp., Cambridge  NeuroScience,  Genelabs  Technologies,  COR Therapeutics,
Curative  Technologies,  Alkermes,  Osteotech,  Vertex,  Genetic  Therapy,  IDEC
Pharmaceuticals,  Sepracor Inc.,  CellPro Inc.,  Alteon Inc.,  ImClone  Systems,
Magainin   Pharmaceuticals  and  Genta.  Other   biotechnology/biopharmaceutical
companies  which had IPOs in 1991 are not included  here if they no longer exist
or are no longer publicly traded. Because of this, Aphton's relative stock price
performance is negatively impacted from what is commonly called in the financial
industry a "survivor bias."
<TABLE>
            <S>                 <C>     <C>    <C>     <C>     <C>    <C>     <C>    <C>     <C>     <C>
                               1991    1/31   1/29    1/31    1/31    1/31   1/31    1/30    1/29   1/31
      Period from IPO          IPO     1992   1993    1994    1995    1996   1997    1998    1999   2000
Aphton Corporation             100     304     220    350      139     146     318    177     223    350
All US & Foreign on NASDAQ*    100     131     147    171      161     227     296    348     535    858
Biotech Peer Group             100     160     136    118       63     133     128    139     179    222

                                                              1/31   1/31    1/31    1/30   1/29    1/31
     Five years ended January 31, 2000                        1995   1996    1997    1998   1999    2000
Aphton Corporation                                            100     105     228    128     160     238
All US & Foreign on NASDAQ*                                   100     125    163     192     302     474
Biotech Peer Group                                            100      60     57      63      81     352
</TABLE>

                             Executive Compensation
The  following  table sets forth,  for each of the last five fiscal  years,  the
annual  compensation  paid by the Company,  together  with  long-term  and other
compensation,  for the Chief Executive  Officer,  the Co-Chief Executive Officer
and the other  highest  compensated  Executive  Officers  of the  Company in all
capacities in which they served.
<TABLE>
       <S>               <C>       <C>       <C>       <C>             <C>          <C>      <C>           <C>
                                                 Summary Compensation Table
                                      Annual Compensation                  Long-Term Compensation
                                 -------------------------------    --------------------------------------
                                                                         Awards              Payouts
                                                                  ----------------------    -----------
                                                                                            Long-Term
                                                       Other                                Incentive
     Name, Age and       Fiscal                        Annual      Restricted               Plan         All Other
  Principal Position     Period                        Compen-sation Stock       Options/   Payouts($)    Compen-
                          End    Salary($)  Bonus($)      ($)     Award(s)($)    SARs(#)                sation ($)
------------------------
Philip C. Gevas (66)       2000  200,000    200,000        -           -            -           -            -
Chairman of the Board of   1999  200,000    200,000        -           -            -           -            -
Directors, Chief Executive*1998  150,000    200,000        -           -            -           -            -
Officer and President      1997  200,000    200,000        -           -            -           -            -
                           1996  200,000    200,000        -           -            -           -            -


William A. Hasler (58),    2000  180,000       -          -           -         150,000        -            -
Vice-Chairman of the             105,000       -          -           -             -          -            -
Board of Directors and           (Note !)
Co-Chief Executive Officer

Dov Michaeli, M.D.,        2000  150,000      60,000       -           -            -           -            -
Ph.D. (62) Senior Vice     1999  150,000      60,000       -           -            -           -            -
President, Director of    *1998  112,500      60,000       -           -            -           -            -
Medical Science            1997  150,000      60,000       -           -            -           -            -
                           1996  150,000      60,000       -           -            -           -            -


Paul Broome, MB.,          2000  135,000      30,000       -           -            -           -            -
Ch.B., MFPM (48)           1999  135,000      30,000       -           -            -           -            -
Vice President and        *1998   93,750      30,000       -           -            -           -
Medical Director,          1997  135,000      30,000       -           -            -           -
Clinical Trials and        1996  132,300      25,000       -           -            -           -
Regulatory Affairs

Richard Ascione,           2000  130,000      30,000       -           -            -           -            -
Ph.D.(62) Vice             1999  125,000      25,000       -           -            -
President, Director of    *1998   87,500      25,000       -           -            -           -            -
Laboratory of              1997  125,000      25,000       -           -            -           -            -
Molecular Medicine         1996  125,000      25,000       -           -            -           -            -
________________________________________
Note 1.  For the seven months ended January 31, 1999
*Nine month fiscal period ended January 31, 1998
</TABLE>



                       Option Grants in Last Fiscal Year
Warrants to purchase 150,000 shares of common stock were granted during the year
ended January 31, 2000 to William Hasler.  The following table shows the options
to purchase the  Company's  Common Stock granted to Mr. Hasler and the potential
value of such grants if the stock price were to  appreciate  at the rates of 5%,
or 10%, compounded annually over the exercise term of the options. Also shown is
the  potential  gain of all  outstanding  shares  of  Common  Stock  held by the
Company's  shareholders  as of January  31,  2000,  using the last sale price of
$24.50  per  share  and the same  appreciation  rates  compounded  over the same
period. The 5% and 10% rates of appreciation are required to be disclosed by the
rules of the Securities and Exchange  Commission ("SEC") and are not intended to
forecast  possible  future actual  appreciation,  if any, in the Company's stock
prices.  The Company did not use an alternative  present value formula permitted
by the rules of the SEC because in the Company's view,  potential future unknown
or volatile  factors  result in there being no such formula  that can  determine
with reasonable accuracy the present value of such option grants.
<TABLE>
      <S>             <C>             <C>             <C>         <C>          <C>         <C>
                                Percent of Total
                    Options/      Options/SARs      Exercise
                      SARs         Granted to        or Base
                     Granted        Employees         Price    Expiration
       Name            (#)       in Fiscal Year      ($/Sh)       Date         5%            10%
                    ---------- -------------------- ---------- ----------- ------------ ---------------

William A. Hasler   150,000            100            14.75    12/31/2015
                                                                             4,577,242       9,154,493
All Stockholders    N/A                N/A            24.50       N/A      790,340,000   1,580,700,000
</TABLE>


                   Option Exercises and Fiscal Year-End Values
The following table sets forth  information  concerning the unexercised  options
held as of the end of the fiscal year. None of these officers  exercised options
during the fiscal year.
                  Option/SAR Exercises and Year-End Value Table
              Aggregated Option/SAR Exercises in Last Fiscal Year,
                           and FY-End Option/SAR Value
<TABLE>
       <S>                         <C>           <C>           <C>            <C>           <C>          <C>
                                                               Number of Unexercised        Value of Unexercised
                                                                     Options/               In-the-Money Options/
                                   Shares                        SARs at FY-End(#)          SARs at FY-End($)(1)
                                                            ----------------------------
                                 Acquired on      Value
------------------------------   Exercise(#)   Realized($)  Exercisable  Unexercisable   Exercisable  Unexercisable
             Name
Philip C. Gevas                       -             -         600,000          -         $5,520,000         -
William A. Hasler                     -             -         186,000                    $1,813,500
Dov Michaeli, M.D, Ph.D.              -             -         370,000          -         $5,065,000
Richard Ascione, Ph.D.                -             -            -           50,000           -          $585,000
Paul Broome, MB., Ch.B., MFPM         -             -            -           50,000           -          $585,000

</TABLE>
(1) Market value of shares covered by in-the-money  options on January 31, 2000,
less option exercise price.  Options are in-the-money if the market value of the
shares covered  thereby is greater than the option  exercise  price.  The market
value is the closing price at January 31, 2000, as quoted by Nasdaq.

                Long-Term Incentive Plans - Awards in Fiscal Year
No long-term  incentive  plan awards were granted  during the year ended January
31, 2000.
                             Principal Shareholders
To  the  Company's  knowledge,   except  as  hereinafter  described,  no  single
shareholder of record owned or beneficially  owned, as of May 8, 2000, more than
5% of the Company's  common stock.  As of May 8, 2000,  Cede & Co., a nominee of
securities  depositories  for various segments of the financial  industry,  held
approximately 11,012,000 shares, representing approximately 69% of the Company's
outstanding common stock, none of which was owned beneficially by Cede & Co. The
Company  believes  that  each  of  the  entities  or  individuals   named  below
beneficially owns 5% or more of the Company's common stock, based on a review of
filings made with the SEC.
<TABLE>
               <S>                              <C>                 <C>
          Name and Address of
            Beneficial Owner               Number of Shares   % of Common Stock

Smith Barney  Mutual  Funds  Management,      1,856,900             11.5
Inc
388 Greenwich Street
Legal Dept, 20th Floor
New York, New York 10013

Philip C. Gevas                               1,859,050             11.5
P.O. Box 1049
Woodland, CA 95776

Richard L. Littenberg, M.D.                     846,250              5.2
P.O. Box 1049
Woodland, CA 95776

Robert J. Scibienski, Ph.D.                   1,413,800              8.7
P.O. Box 1049
Woodland, CA 95776

All Executive Officers and                    2,124,216             13.1
Directors as a group (10 persons)
</TABLE>


                              Shareholder Proposals

If a shareholder intends to have a proposal presented at the next Annual Meeting
of  Shareholders,  such a  proposal  must  be  received  by the  Company  at its
principal executive offices prior to the end of fiscal year 2001.

                                  Miscellaneous

Ernst & Young LLP has been voted the Company's  independent  accountants for the
fiscal year 2001.

It is anticipated that a  representative  from  PricewaterhouseCoopers  LLP, the
Company's  independent  accountants for many fiscal years,  will be available to
answer  questions  raised at the  Annual  Meeting  of  Shareholders  and will be
afforded the opportunity to make any statements the representative may desire to
make.

The Board of Directors  knows of no other matters that are likely to come before
the  meeting.  If any such  matters  should  properly  come before the  meeting,
however, it is intended that the persons named in the accompanying form of proxy
will vote such proxy in accordance with their best judgment on such matters.

By Order of the Board of Directors
     /s/
Philip C. Gevas
Chairman and Secretary


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