CATALYTICA INC
10-Q, 1998-08-14
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>
 
                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                        
                                   FORM 10-Q
(Mark One)

[X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
    ACT OF 1934

    For the quarterly period ended JUNE 30, 1998

                                       or

[_] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
    ACT OF 1934

    For the transition period from _________________to ______________.

                          Commission File No. 0-20966

                                ---------------
                                        
                                CATALYTICA, INC.
             (Exact name of Registrant as specified in its charter)

           DELAWARE                                         94-2262240
(State or other jurisdiction of                           (IRS Employer
 incorporation or organization)                       Identification Number)
                                        
                               430 FERGUSON DRIVE
                        MOUNTAIN VIEW, CALIFORNIA 94043
                    (Address of principal executive offices)
                                        
                                 (650) 960-3000
              (Registrant's telephone number, including area code)

  Indicate by check mark whether the Registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
Registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days. Yes [X]    No [_]

  As of August 7, 1998, there were outstanding 28,162,904 shares of the
registrant's Common Stock, par value $.001, which is the only class of common
stock of the registrant registered under Section 12(g) of the Securities Act of
1933.  The Company also has outstanding 13,270,000 shares of Class A Common
Stock and 11,730,000 shares of Class B Common Stock which are convertible into
an equal number of shares of Common Stock.
<PAGE>
 
                                CATALYTICA, INC.

                                   FORM 10-Q

                               TABLE OF CONTENTS

                                 JUNE 30, 1998
                                        
<TABLE>
<CAPTION>
                                                                                                          PAGE NO.
<S>                                                                                                       <C>
PART I. FINANCIAL INFORMATION
 
ITEM 1. FINANCIAL STATEMENTS (UNAUDITED)
 
   Unaudited Condensed Consolidated Balance Sheets as of June 30, 1998 and December 31, 1997                    3-4
 
   Unaudited Condensed Consolidated Statements of Operations for the three and six months ended June
    30, 1998 and June 30, 1997                                                                                    5
 
   Unaudited Condensed Consolidated Statements of Cash Flows for the six months ended June 30, 1998
    and June 30, 1997                                                                                             6
 
   Notes to Unaudited Condensed Consolidated Financial Statements                                                 7
 
ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF
        OPERATIONS                                                                                               12
 
PART II. OTHER INFORMATION
 
ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS                                                      23
 
ITEM 5. OTHER INFORMATION                                                                                        23
 
ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K                                                                         24
 
SIGNATURES                                                                                                       25
 
</TABLE>

                                       2
<PAGE>
 
PART I--FINANCIAL INFORMATION

ITEM 1. FINANCIAL STATEMENTS

                                CATALYTICA, INC.
                UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS
                                 (IN THOUSANDS)
                                        
<TABLE>
<CAPTION>
                                                                                   JUNE 30,          DECEMBER 31,
                                                                                     1998                1997
                                                                             ------------------  ------------------
<S>                                                                          <C>                 <C>
ASSETS
Current assets:
  Cash and cash equivalents                                                  $ 37,330            $ 35,149
  Short-term investments                                                       12,001              11,918
    Accounts receivable, net                                                   20,175              12,640
  Accounts receivable from joint venture                                          271                 967
  Notes receivable from employees                                                 967                 405
  Inventory:                                                
     Raw materials                                                             43,926              52,648
     Work in process                                                           49,370              54,883
     Finished goods                                                             7,469               6,714
                                                                             --------            --------
                                                                              100,765             114,245
      Deferred tax asset                                                          166                 166
   Prepaid expenses and other assets                                            2,078               1,939
                                                                             --------            --------
     Total current assets                                                     173,753             177,429
Property, plant and equipment:                              
       Land                                                                     5,391               5,391
  Equipment                                                                   106,012              99,744
  Buildings and leasehold improvements                                         66,900              65,744
                                                                             --------            --------
                                                                              178,303             170,879
  Less accumulated depreciation and amortization                              (21,420)            (15,075)
                                                                             --------            --------
                                                                              156,883             155,804
Other assets                                                                    3,371               2,040
                                                                             --------            --------
                                                                             $334,007            $335,273
                                                                             ========            ========
</TABLE>

                            See accompanying notes.

                                       3
<PAGE>
 
                                CATALYTICA, INC.
                UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS
                                 (IN THOUSANDS)
                                        
<TABLE>
<CAPTION>
                                                                                       JUNE 30,          DECEMBER 31,
                                                                                         1998                1997
                                                                                  ------------------  ------------------
<S>                                                                               <C>                 <C>
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
  Accounts payable                                                                $ 17,314            $ 23,281
  Accrued payroll and related expenses                                               9,659               5,768
  Deferred revenue                                                                   1,758               1,848
  Other accrued liabilities                                                          6,321               8,250
  Current portion of long-term debt                                                 10,331              50,332
  Income taxes payable                                                                 399                 525
                                                                                  --------            --------
     Total current liabilities                                                      45,782              90,004
                                                                 
Long-term debt                                                                      77,712              75,069
Non-current deferred revenue                                                         2,914               3,611
Other accrued liabilities                                                            6,400               6,400
Minority interest                                                                   41,000              11,000
Class A and B common stock                                                          97,079              97,079
                                                                 
Stockholders' equity:                                            
  Common Stock                                                                          32                  28
  Additional paid-in capital                                                       102,035             100,375
  Deferred compensation                                                               (344)               (406)
  Accumulated deficit                                                              (38,603)            (47,887)
                                                                                  --------            --------
     Total stockholders' equity                                                     63,120              52,110
                                                                                  --------            --------
                                                                                  $334,007            $335,273
                                                                                  ========            ========
</TABLE>
                                                                                
                            See accompanying notes.

                                       4
<PAGE>
 
                                CATALYTICA, INC.
           UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                    (IN THOUSANDS, EXCEPT PER SHARE AMOUNTS)

<TABLE>
<CAPTION>
                                                THREE MONTHS ENDED JUNE 30,           SIX MONTHS ENDED JUNE 30,
                                                1998               1997               1998                1997
                                         ------------------  -----------------  -----------------  -------------------
<S>                                      <C>                 <C>                <C>                <C>
Revenues:
  Product sales                           $93,766            $ 6,262           $184,046              $ 9,321
  Research revenues                         2,311              1,500              4,165                3,226
                                          -------            -------           --------              -------
                                           96,077              7,762            188,211               12,547
Costs and expenses:                      
  Cost of sales                            77,696              6,013            154,808                9,087
  Research and development                  6,259              2,240             10,095                4,439
  Selling, general and administrative       3,829              1,001              7,256                1,991
                                          -------            -------           --------              -------
                                         
Total costs and expenses                   87,784              9,254            172,159               15,517
                                         
Operating income (loss)                     8,293             (1,492)            16,052               (2,970)
                                         
Interest income                               646                239              1,555                  505
Interest expense                           (2,394)              (125)            (5,019)                (238)
Loss on joint venture                      (1,152)              (450)            (2,307)              (1,450)
                                          -------            -------           --------              -------
                                         
Income (loss) before income taxes           5,393             (1,828)            10,281               (4,153)
                                         
Provision for income taxes                   (360)                --               (997)                  --
                                          -------            -------           --------              -------
                                         
Net income (loss)                         $ 5,033            $(1,828)          $  9,284              $(4,153)
                                          =======            =======           ========              =======
                                         
Net income (loss) per share:             
Basic                                     $  0.09            $ (0.09)          $   0.16              $ (0.21)
                                          =======            =======           ========              =======
Diluted                                   $  0.08            $ (0.09)          $   0.15              $ (0.21)
                                          =======            =======           ========              =======
                                         
Number of shares used in computing net   
 income (loss) per share:                
Basic                                      53,035             19,918             52,993               19,987
                                          =======            =======           ========              =======
Diluted                                    59,616             19,918             58,936               19,987
                                          =======            =======           ========              =======
</TABLE>
                            See accompanying notes.

                                       5
<PAGE>
 
                                CATALYTICA, INC.
           UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS
                                 (IN THOUSANDS)

<TABLE>
<CAPTION>
                                                                                             SIX MONTHS ENDED JUNE 30,
                                                                                             1998                 1997
                                                                                     -------------------  -------------------
<S>                                                                                      <C>                  <C>
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income (loss)                                                                        $  9,284             $ (4,153)
Adjustments to reconcile net income (loss) to net cash provided by (used in)
 operating activity:
  Depreciation and amortization                                                             7,078                  630
        Deferred income taxes                                                                  --                   --
  Losses in affiliated company                                                              2,308                1,450
  Changes in:
     Accounts receivable                                                                   (7,535)              (1,293)
     Accounts receivable from joint venture                                                   696                  533
     Inventory                                                                             13,480                1,712
     Prepaid expenses and other current assets                                             (1,948)              (3,892)
     Accounts payable                                                                      (5,967)                (468)
     Accrued payroll and related expenses                                                   3,891                  251
     Deferred revenue                                                                        (787)                (793)
     Accrued acquisition costs                                                                (70)               1,069
     Other accrued liabilities                                                             (1,985)                (200)
                                                                                         --------             --------
        Net cash provided by (used in) operating activities                                18,445               (5,154)
 
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of investments                                                                  (23,762)             (13,184)
Maturities of investments                                                                  24,000               17,028
Investment in affiliate company                                                            (2,308)              (1,450)
Disposition of property and equipment                                                         125                   --
Acquisition of property and equipment                                                      (7,558)              (2,960)
                                                                                         --------             --------
        Net cash used in investing activities                                              (9,503)                (566)
 
CASH FLOWS FROM FINANCING ACTIVITIES:
Net receipts on (issuance of) notes receivable from employees                              (1,067)                  73
Additions to debt obligations                                                               2,700                1,645
Payments on debt obligations                                                              (40,058)                (735)
Minority investment                                                                        30,000                   --
Issuance of stock, net of issuance costs                                                    1,664                  569
                                                                                         --------             --------
        Net cash provided by (used in) financing activities                                (6,761)               1,552
                                                                                         --------             --------
 
Net increase (decrease) in cash and cash equivalents                                        2,181               (4,168)
Cash and cash equivalents at beginning of period                                           35,149               15,540
                                                                                         --------             --------
Cash and cash equivalents at end of period                                               $ 37,330             $ 11,372
                                                                                         ========             ========
</TABLE>
                            See accompanying notes.

                                       6
<PAGE>
 
         NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
                                        
1. BASIS OF PRESENTATION

  The accompanying unaudited condensed consolidated financial statements have
been prepared in accordance with generally accepted accounting principles for
interim financial information and with the instructions to Form 10-Q and Article
10 of Regulation S-X. Accordingly, they do not include all of the information
and footnotes required by generally accepted accounting principles for complete
financial statements. In the opinion of management, all adjustments (consisting
of normal recurring accruals) considered necessary for a fair presentation have
been included. Operating results for the six-month period ended June 30, 1998,
are not necessarily indicative of the results that may be expected for the year
ended December 31, 1998. For further information, refer to the consolidated
financial statements and footnotes thereto included in the Catalytica, Inc.
Annual Report on Form 10-K for the year ended December 31, 1997.

2. EARNINGS (LOSS) PER SHARE

  Earnings (loss) per share is presented in accordance with Financial Accounting
Standards Board (FASB) Statement of Financial Accounting Standards (SFAS) No.
128, "Earnings Per Share" (EPS). This statement requires the presentation of EPS
to reflect both "Basic EPS" and "Diluted EPS" on the face of the statement of
operations. For the three and six months ended June 30, 1997, the inclusion of
common stock equivalents is antidilutive, therefore loss per share is computed
based on the weighted average number of common shares outstanding excluding
common stock equivalents for this period. Weighted average shares outstanding
for the three and six months ended June 30, 1998 includes Class A and B common
shares as Catalytica, Inc. ("the Company") considers Class A and B to be the
equivalent of common stock.  The periods presented herein have been adjusted to
reflect the calculation of EPS in accordance with SFAS No. 128.

                                       7
<PAGE>
 
  A reconciliation of the numerators and denominators for the Basic and Diluted
EPS calculations follows:

<TABLE>
<CAPTION>
                                                            THREE MONTHS ENDED JUNE 30,      SIX MONTHS ENDED JUNE 30,
                                                                1998            1997            1998           1997
                                                           --------------  --------------  --------------  -------------
<S>                                                        <C>             <C>             <C>             <C>
NUMERATOR:
 
  Numerator for basic earnings per share:  Income
   available to  common shareholders                             $ 5,033         $(1,828)        $ 9,284        $(4,153)
 
   Less:  Reduction of Catalytica Pharmaceuticals income
    attributable to holders of subsidiary stock options             (312)             --            (561)            --
                                                                 -------         -------         -------        -------
  Numerator for diluted earnings per share                         4,721          (1,828)          8,723         (4,153)
 
DENOMINATOR:
 
 Denominator for basic earnings per share
  Weighted-average shares                                         53,035          19,918          52,993         19,987
                                                                 -------         -------         -------        -------
 Effect of dilutive securities:
  Catalytica, Inc. employee stock options                            879              --             745             --
  Catalytica Pharmaceuticals Convertible Preferred Stock
                                                                   1,691              --           1,691             --
  Catalytica Pharmaceuticals Convertible Junior
   Preferred Stock                                                   570              --             570             --
 
  Catalytica Combustion Systems, Inc. Convertible
   Preferred Stock                                                 2,664              --           2,664             --
 
  Catalytica, Inc. warrants issued to Glaxo Wellcome,
   Inc.                                                              777              --             273             --
                                                                 -------         -------         -------        -------
     Dilutive potential common shares                              6,581              --           5,943             --
 
 Denominator for diluted earnings per share
  Adjusted weighted-average shares and assumed
   conversions                                                    59,616          19,918          58,936         19,987
                                                                 -------         -------         -------        -------
 
 Basic earnings per share                                        $  0.09          ($0.09)        $  0.16        $ (0.21)
                                                                 =======         =======         =======        =======
 Diluted earnings per share                                      $  0.08          ($0.09)        $  0.15        $ (0.21)
                                                                 =======         =======         =======        =======
</TABLE>

                                       8
<PAGE>
 
3. IMPACT OF STATEMENT OF FINANCIAL ACCOUNTING STANDARDS NO. 130

  Effective January 1, 1998, the Company adopted Statement of Financial
Accounting Standards No. 130, "Reporting Comprehensive Income." This Statement
requires that all items recognized under accounting standards as components of
comprehensive earnings be reported in an annual financial statement that is
displayed with the same prominence as other annual financial statements. This
Statement also requires that an entity classify items of other comprehensive
earnings by their nature in an annual financial statement. For example, other
comprehensive earnings may include foreign currency translation adjustments,
minimum pension liability adjustments, and unrealized gains and losses on
marketable securities classified as available-for-sale. Annual financial
statements for prior periods will be reclassified, as required. The Company has
no comprehensive earnings adjustments for the three and six months ended June
30, 1998 and 1997, thus total comprehensive earnings is equal to net earnings
(loss).

4. FINANCIAL INSTRUMENTS

  For the purposes of the consolidated cash flows, all investments with
maturities of three months or less at the date of purchase held as available-
for-sale are considered to be cash and cash equivalents; instruments with
maturities of three months or less at the date of purchase that are planned to
be held-to-maturity ($12,001,374 at June 30, 1998) and investments with
maturities greater than three months that are available-for-sale (none at June
30, 1998) are considered to be short-term investments; investments with
maturities greater than one year are considered to be long-term investments and
are available-for-sale (none at June 30, 1998). All investments at June 30,
1998, were carried at amortized cost, which approximated fair market value
(quoted market price).  The classification of investments is made at the time of
purchase with classification for held-to-maturity made when the Company has the
positive intent and ability to hold the investments to maturity.

5. USE OF ESTIMATES

  The preparation of financial statements in conformity with generally accepted
accounting principles requires management to make estimates and assumptions that
affect the reported amounts of assets and liabilities and disclosure of
contingent assets and liabilities at the date of financial statements and the
reported amounts of revenues and expenses during the reporting period. Actual
results could differ from those estimates.

6.  REVENUE RECOGNITION

  In connection with the purchase of the Glaxo Wellcome, Inc. ("Glaxo Wellcome")
facility in Greenville, North Carolina ("Greenville Facility") by the Company on
July 31, 1997, Glaxo Wellcome entered into a Supply Agreement under which
Catalytica Pharmaceuticals, Inc., a subsidiary of the Company ("Catalytica
Pharmaceuticals"),  has been and will continue to manufacture products for Glaxo
Wellcome.  During the quarter ended June 30, 1998, the original Supply Agreement
was amended to expand production of Glaxo Wellcome products at the Greenville
Facility in 1998 and 1999.  Glaxo Wellcome has guaranteed that revenues paid to
Catalytica Pharmaceuticals will meet a specified level of minimum revenue or
that Glaxo Wellcome will pay  Catalytica Pharmaceuticals any shortfall.

  The Company recognizes revenue under the Supply Agreement with Glaxo Wellcome
based upon the minimum revenues under this agreement.  All other product
revenues are recorded upon shipment.  During the three and six months ended June
30, 1998, the Company recorded $83 and $166 million, respectively, of revenue
derived from sales to Glaxo Wellcome.

  As of June 30, 1998, a receivable in the amount of $10.2 million was
outstanding from Glaxo Wellcome.

7. DEBT
 
  In conjunction with the acquisition of the Greenville Facility, the Company
entered into a Credit Agreement pursuant to which a syndicate of banks led by
Chase Securities, Inc. ("Chase") agreed to lend Catalytica Pharmaceuticals an
aggregate of up to $200,000,000 (the "Debt Facilities"). The Debt Facilities
consisted of a senior 

                                       9
<PAGE>
 
secured term loan facility (the "Term Debt Facility") in an aggregate principal
amount of $125,000,000 and a senior secured revolving facility (the "Revolving
Debt Facility") in an aggregate principal amount of $75,000,000. In the quarter
ended June 30, 1998, this Credit Agreement was amended to increase the Revolving
Debt Facility from $75,000,000 million to $100,000,000. In addition, the Term
Debt Facility was reduced from its original balance of $125,000,00 million to
$75,000,000. Up to $20,000,000 of the Revolving Debt Facility is available for
the issuance of letters of credit. The Term Debt Facility which originally
matured December 31, 2001 will now mature December 31, 2002 and will amortize in
quarterly installments commencing on December 31, 1999. The Bank Credit
Agreement, which is guaranteed by the Company, requires that the Company
maintain certain financial ratios and levels of tangible net worth,
profitability, and liquidity and implements restrictions on the Company's
ability to declare and pay dividends. The senior secured facility interest rate
is a variable interest rate tied to LIBOR. This interest rate was 6.69% as of
June 30, 1998. As of June 30, 1998, $10,000,000 was outstanding under the
Revolving Debt Facility and $75,000,000 was outstanding under the Term Debt
Facility.

  In addition to the restrictions above, the Bank Credit Agreement contains
various covenants restricting further indebtedness, issuance of preferred stock
by the Company or its subsidiaries, liens, acquisitions, asset sales, and
capital expenditures. At June 30, 1998, the Company and Catalytica
Pharmaceuticals, Inc. were in compliance with the covenants.
 
  In the second quarter of 1998 following the restructuring of the Bank Credit
Agreement,  the Company entered into a $50,000,000 interest rate swap,
derivative transaction to reduce the Company's exposure to fluctuations in
short-term interest rates.   This interest rate swap transaction effectively
fixed the LIBOR benchmark rate used to calculate the Company's borrowing cost at
5.9% for 4 years on $50,000,000 of the Term Debt Facility.  The Company accounts
for this interest rate swap as a hedge, and accrues the interest rate
differential as interest expense on a monthly basis.

  During the second quarter of 1998, the Company received a $2.7 million non-
interest bearing loan from a customer to be used to finance special equipment
requirements.  The loan is payable in aggregate annual amounts of (i) $.7
million on December 31, 1999;  (ii) $1 million on December 31, 2000; and  (iii)
$ 1 million on December 31, 2001.

8. FORMATION OF GENXON/(TM)/ JOINT VENTURE WITH WOODWARD GOVERNOR COMPANY

  On October 15, 1996 Catalytica's subsidiary Catalytica Combustion Systems,
Inc. ("Combustion Systems") and Woodward Governor Company formed a Delaware
limited liability company in connection with a 50/50 joint venture to serve the
gas turbine retrofit market for installed, out-of-warranty engines. The new
company, GENXON/(TM)/ Power Systems, LLC, will initially upgrade the combustion
systems of installed turbines with XONON, which is designed to reduce emissions
and permit greater asset utilization for both power generation and mechanical
drive markets.

  Subsequent to the initial funding of $10 million, which was completed during
the quarter ended September 30, 1997, continued funding of the joint venture
beyond the initial commitment has occurred on a 50/50 basis with each joint
venture partner contributing an equal amount quarterly.  For the three and six
months ended June 30, 1998, each partner contributed $1.4 and $2.6 million,
respectively, bringing the total combined investment in the joint venture to
$19.95 million to date. Although the Company believes that Combustion Systems
and Woodward intend to continue the funding of this joint venture, neither joint
venture partner is contractually required to make further capital infusions.

  Combustion Systems recognized its 50% share of GENXON losses, of $2.3 million,
of which $1.15 million was Combustion Systems' 50% of GENXON's loss for the
three months ended June 30, 1998, and $4.6 million, of which $2.3 million was
Combustion Systems' 50% of GENXON's loss  for the six months ended June 30,
1998.  Accordingly, losses on the joint venture were recognized in the results
of operations.

  As of June 30, 1998, an account receivable for $271,000 existed from the joint
venture for costs incurred by Combustion Systems. Accordingly these costs have
not been included in the consolidated entity.

                                       10
<PAGE>
 
NOTE 9.  INCOME TAXES

  The provision for income taxes for the three and six months ended June 30,
1998 was approximately 7% and 10%, respectively,  as compared to 0% for the
corresponding periods in 1997.  The increase in the estimated annual tax rate is
due primarily to state income taxes relating to the Greenville facility coupled
with the federal alternative minimum tax.

                                       11
<PAGE>
 
ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
AND RESULTS OF OPERATIONS

OVERVIEW

     This report contains forward-looking statements within the meaning of
Section 27A of the Securities Act and Section 21E of the Exchange Act, which
involve risks and uncertainties including but not limited to those statements
that have been identified by an asterisk ("*") and other statements regarding
the Company's strategy, financial performance and revenue sources. The Company's
actual results could differ materially from the results anticipated in these
forward-looking statements as a result of certain factors including those set
forth under "Risk Factors" and elsewhere in this Report.

     The Company is creating new businesses that leverage the Company's
proprietary catalytic technologies to yield economic and environmental benefits
by lowering manufacturing costs and reducing hazardous byproducts. Catalytica
currently is focused on applying its capabilities to two primary areas: (i)
production of pharmaceutical components and products; (ii) developing advanced
combustion systems to reduce toxic emissions generated by natural gas turbines.
To pursue these opportunities, the Company has created two operating
subsidiaries, Catalytica Pharmaceuticals, Inc. ("Catalytica Pharmaceuticals")
and Catalytica Combustion Systems, Inc. ("Combustion Systems"). In addition to
market focus, the formation of subsidiaries provides greater flexibility for
strategic financial arrangements and business partnerships.  A third subsidiary,
Catalytica Advanced Technologies ("Advanced Technologies"), is exploring new
business opportunities and markets for the Company's technologies.

     On July 31, 1997, Catalytica Pharmaceuticals, Inc. (formerly Catalytica
Fine Chemicals, Inc.), a subsidiary of the Company, acquired from Glaxo
Wellcome, Inc. a pharmaceutical manufacturing facility (the "Greenville
Facility") located in Greenville, North Carolina (the "Acquisition"), in
exchange for (i) $244.7 million in cash (after certain post closing
adjustments); (ii) 250,000 shares of Junior Preferred Stock of Catalytica
Pharmaceuticals; (iii) warrants to purchase 2,000,000 shares of the Company's
Common Stock at an exercise price of $12.00 per share and (iv) 10% of the
earnings before interest and taxes prior to July 31, 2007, in excess of an
aggregate cumulative amount of $10 million attributable to the Sterile Product
Operations ("SPO") portion of the Greenville Facility, up to an aggregate
cumulative payment to Glaxo Wellcome of an additional $25.0 million.

     To raise the cash needed to complete the Acquisition, the Company used a
combination of equity and debt financing.  With the closing of the Acquisition,
the Company completed the sale of 13,270,000 shares of its Class A Common Stock
and 16,730,000 shares of its Class B Common Stock to Morgan Stanley Capital
Partners III, L.P. and two affiliated funds ("MSCP") (collectively, the "Stock
Sale"), at a price of $4.00 per share, for an aggregate of $120,000,000. The
Class A and B stock are convertible into common stock of the Company on a share
for share basis.  In November of 1997, the Company repurchased 5,000,000 of the
Class B MSCP shares at $4.75 per share with the proceeds from the issuance of a
warrant dividend granted to its stockholders in connection with the financing of
the acquisition.

     In addition to the equity investment by MSCP, the Company, The Chase
Manhattan Bank ("Chase") and Chase Securities Inc. ("CSI") entered into a Credit
Agreement pursuant to which a syndicate of banks led by Chase agreed to lend
Catalytica Pharmaceuticals an aggregate of up to $200,000,000 (the "Debt
Facilities"). The Debt Facilities consisted of a senior secured term loan
facility (the "Term Debt Facility") in an aggregate principal amount of
$125,000,000 and a senior secured revolving facility (the "Revolving Debt
Facility") in an aggregate principal amount of $75,000,000. In the quarter ended
June 30, 1998, this Credit Agreement was amended to increase the Revolving Debt
Facility from $75,000,000 million to $100,000,000.  In addition, the Term Debt
Facility was reduced from its original balance of  $125,000,00 million to
$75,000,000. In the second quarter of 1998, the Company also entered into an
interest rate swap, derivative transaction which fixed the LIBOR benchmark rate
used to calculate the Company's borrowing cost at 5.9% plus the spread in the
Bank Credit Agreement for 4 years on $50,000,000 of the Term Debt Facility. As
of June 30, 1998,  $10,000,000 was outstanding under the revolving debt facility
and $75,000,000 was outstanding under the Term Debt Facility. (See Note 7 to
Unaudited Condensed Consolidated Financial Statements).

     The additional facilities, employees and business volumes resulting from
the Acquisition have substantially increased the expenses and working capital
requirements and placed increased burdens on the Company's management resources.
Furthermore, the success of the Company's future results depends, in significant
part, on the levels of new manufacturing business developed by Catalytica
Pharmaceuticals.* In the event Catalytica Pharmaceuticals does not obtain
additional new customers, which could involve additional business from Glaxo
Wellcome, on terms sufficient to offset the costs associated with operating and
maintaining the Greenville Facility, and with servicing the debt incurred in
connection with the acquisition of the Greenville Facility, the Company's
consolidated results of operations and financial condition would be materially
adversely affected.

                                       12
<PAGE>
 
     Due to the size of the Acquisition, the results of operations of Catalytica
Pharmaceuticals have a material affect on the consolidated results of operations
of the Company, and the results of operations of the Company's other businesses
are expected to only modestly impact consolidated results for fiscal year 1998.*
The anticipated revenues from the Supply Agreement with Glaxo Wellcome are
expected to allow the Company to achieve continued profitable operations for
Catalytica Pharmaceuticals throughout 1998, and the consolidated parent Company
as well, offsetting losses arising from continued investments in the Company's
Combustion Systems and Advanced Technologies businesses.* After 1998, Catalytica
Pharmaceuticals' profitability will depend on its success and timing in
obtaining additional new customers, including possible new agreements with Glaxo
Wellcome.* Profitability on a consolidated basis will depend on the operating
results of each of the Company's subsidiaries, particularly the rate of
commercial success of Catalytica Combustion Systems*

     Manufacturing at the Greenville Facility is conducted in three district
operations: Chemical Manufacturing Operations ("CMO"), Pharmaceutical Product
Operations ("PPO") and Sterile Product Operations ("SPO").  There is substantial
excess manufacturing capacity immediately available at the PPO and SPO
facilities, but because of the long lead times required to obtain necessary
regulatory approvals to manufacture final dosage products at these facilities,
Catalytica Pharmaceuticals does not anticipate additional significant revenue
from such facilities until late in 1998 or 1999 at the earliest.* The inability
of Catalytica Pharmaceuticals to fill additional available capacity or to reduce
costs in conjunction with lower levels of capacity utilization would have a
material adverse effect on the Company's results of operations and financial
condition.

     Catalytica Pharmaceuticals also owns and operates a flexible, multi-
purpose, commercial scale manufacturing plant in East Palo Alto, California,
which has approximately 12,000 gallons of reactor capacity set up in a wide
range of reactor sizes ("Bayview Facility").  The Bayview Facility includes a
pilot plant used for scaling up manufacturing processes and a solids handling
facility that operates under current Good Manufacturing Practices ("cGMP").
This facility was acquired in 1993 from Novartis (formerly Sandoz).

     On May 8, 1996, Catalytica Pharmaceuticals, announced that Pfizer Inc.
("Pfizer") had signed an agreement to invest $15 million in Catalytica
Pharmaceuticals. These funds originally provided Pfizer a 15% interest in
Catalytica Pharmaceuticals and a five-year research and development ("R&D")
commitment by Catalytica Pharmaceuticals to develop new processes and technology
for the manufacture of Pfizer products. Prior to this investment, Catalytica
Pharmaceuticals was a wholly-owned subsidiary of Catalytica, Inc. Pursuant to
the terms of the Greenville Acquisition, Glaxo Wellcome received approximately a
1.5% equity interest in Catalytica Pharmaceuticals and the Company purchased
additional shares of Catalytica Pharmaceuticals, which resulted in Pfizer's
ownership interest decreasing to approximately 4.4%. The Company owns the
remaining 94.1% outstanding equity interest in Catalytica Pharmaceuticals.

     During the past four years, Catalytica Pharmaceuticals and Pfizer have
collaborated on the development of proprietary processes for key intermediate
products for several of Pfizer's promising new pharmaceuticals. During the first
quarter of 1998, Catalytica Pharmaceuticals and Pfizer signed a new
collaborative agreement to begin research and development into new drug
formulations.  Under the new agreement, Catalytica Pharmaceuticals through it's
Greenville Facility, will now provide expertise in development of innovative
processes for the manufacture of tablets, capsules, injectable products, and
other formulations for releasing medications internally.  The new agreement with
Pfizer extends the aforementioned existing R&D relationship between the two
companies, established in 1996, under which Catalytica Pharmaceuticals has
focused on the development of new processes for synthesizing chemical compounds
for the production of Pfizer drugs.  The Pfizer drugs are at varying stages of
approval by the Food and Drug Administration ("FDA"), ranging from Phase II
clinical trials through the New Drug 

                                       13
<PAGE>
 
Application stage. Catalytica Pharmaceuticals currently manufactures
intermediates for certain Pfizer drugs and anticipates becoming a supplier of
intermediates to Pfizer for other pharmaceutical products in the future.* There
can be no assurance, however, that orders will be forthcoming from Pfizer.

     On October 15, 1996 Catalytica's subsidiary Catalytica Combustion Systems
Inc. ("Combustion Systems") and Woodward Governor Company formed a Delaware
limited liability company in connection with a 50/50 joint venture to serve the
gas turbine retrofit market for installed, out-of-warranty engines. The new
company, GENXON/(TM)/ Power Systems, LLC, will initially upgrade the combustion
systems of installed turbines with XONON which is designed to reduce emissions
and permit greater asset utilization for both power generation and mechanical
drive markets.

     Subsequent to the initial funding of $10 million which was completed during
the quarter ended September 30, 1997, continued funding of the joint venture
beyond the initial commitment has occurred on a 50/50 basis with each joint
venture partner contributing an equal amount quarterly.  For the three and six
months ended June 30, 1998, each partner contributed $1.4 and $2.6 million,
respectively, bringing the total combined investment in the joint venture to
$19.95 million to date. Although the Company believes that Combustion Systems
and Woodward intend to continue the funding of this joint venture, neither joint
venture partner is contractually required to make further capital infusions.*

     On January 14, 1998, Enron Ventures Corporation, a wholly-owned subsidiary
of Enron Corporation ("Enron"), purchased a 15% minority interest in Catalytica
Combustion Systems for $30 million in cash.  The Company owns the remaining 85%
outstanding equity interest in Catalytica Combustion Systems. In addition, Enron
also received a three-year option to purchase an additional 5% of Combustion
Systems for $14.4 million in cash.  In connection with the Stock Purchase
agreement, the Company entered into a Share Exchange agreement, providing Enron
the right to exchange the Series B Preferred Stock of Combustion Systems for
Catalytica, Inc. Common Stock.  After the five year anniversary of the
agreement, if Combustion Systems has not undertaken a public offering, in which
Combustion Systems receives proceeds of at least $20 million, Enron shall have
the right to require the Company to exchange all of the outstanding shares of
Series B Preferred Stock for that number of shares of Common Stock based upon a
determined exchange rate. The exchange rate is based upon the fair value of the
Series B Preferred Stock and the market value of Catalytica's Common Stock at
the time of conversion.  Upon consolidation of Combustion Systems into
Catalytica, Inc.,  the Series B Preferred Stock issued to Enron is reflected as
$30 million of minority interest.

     The Company's business had not been profitable until the second half of
1997, and as of June 30, 1998, the Company had an accumulated deficit of $38.6
million. To achieve continued profitable operations, the Company must
successfully manage the operations of the new Greenville Facility, and, to a
lesser extent, successfully develop, manufacture, introduce and market or
license its combustion systems and catalytic processes.* The Company's success
will depend on its ability to complete the transition from emphasizing research
and development to full commercialization and sale of its products.* The Company
began manufacturing, marketing and selling pharmaceutical intermediates in 1994
and, with the Acquisition of the Bayview Facility, substantially increased its
manufacturing of pharmaceutical products.

RESULTS OF OPERATIONS

     Net revenues for the three and six months ended June 30, 1998 increased by
1,138% and 1,400% respectively, compared to the same quarter in fiscal 1997 due
to an increase in product sales attributable to the Greenville Facility and the
related Supply Agreement with Glaxo Wellcome. During the three and six months
ended June 30, 1998, 88%  and 90%, respectively,  of the Company's
pharmaceutical product revenues were derived from sales to Glaxo Wellcome. As
part of the Supply Agreement, Glaxo Wellcome guarantees a specified minimum
level of revenues in each year of the agreement.  To the extent the minimum
level of revenues exceeds revenues due as a result of product shipments, the
Company receives additional payments from Glaxo Wellcome which help offset fixed
manufacturing costs associated with manufacturing capacity reserved for Glaxo
Wellcome as required in the long term Supply Agreement (See Note 6 to Unaudited
Condensed Consolidated Financial Statements). There was a 54% and 29% increase,
respectively, in research revenues for the three and six months of 1998
reflecting a milestone 

                                       14
<PAGE>
 
payment from GENXON to Combustion Systems and an increase in funded research
revenue associated with Advanced Technologies.

     Interest income increased 170% and 208% for the three and six months ended
June 30, 1998, respectively,  when compared to the same period in 1997. Cash and
investments increased due to an increase in product sales and the Enron cash
investment in Catalytica Combustion Systems.  The Enron cash investment has
restrictions related to its use such that these funds cannot be used to retire
debt in other Catalytica subsidiaries such as Catalytica Pharmaceuticals.

     Cost of sales increased 1,192% and 1,604% for the three and six months of
1998.  The increase in cost of sales reflects increased physical volume of
product sales primarily due to an increase in sales attributable to the
Greenville Facility and the related Supply Agreement with Glaxo Wellcome.
Margins on the pharmaceutical products are subject to fluctuations from quarter
to quarter due to various factors including the mix of products being
manufactured, manufacturing efficiencies achieved on production runs, the length
of down-time associated with setting up new productions runs, and numerous other
variables present in the chemical manufacturing environment.

     Research and development expenses increased 179% and 127% for the three and
six months ended June 30, 1998, as compared to the same periods in 1997. This
increase is largely attributable to research and development expenses associated
with the Greenville Facility coupled with increased R&D activity associated with
Combustion Systems and Advanced Technologies. Research and development expenses
may fluctuate from quarter to quarter.

     Selling, general and administrative expenses ("SG&A") increased 283% and
264% for the three and six months ended 1998 compared to the same periods of
1997 largely due to SG&A costs incurred at the Greenville Facility.   SG&A
expenses are expected to increase further in the future as the Company expands
it's sales and marketing personnel to sell the available capacity in the
Facility.*

     Net interest expense increased 1,815% for the second quarter of 1998 and
increased 2,009% for the first six months of 1998 when compared to the same
periods last year due to debt associated with the acquisition of the Greenville
Facility.

     Combustion Systems recognized its 50% share of GENXON losses, of $2.3
million, of which $1.15 million was Combustion Systems' 50% of GENXON's loss for
the three months ended June 30, 1998, and $4.6 million, of which $2.3 million
was Combustion Systems' 50% of GENXON's loss  for the six months ended June 30,
1998.  The Company's capital contribution for the three and six months ended
1998 was $1.4 and $2.6 million, respectively. The Company estimates it may make
additional capital contributions to the joint venture during the remainder of
1998.*  The Company anticipates GENXON will continue to generate losses during
this time frame, and accordingly the Company will record its share of these
losses to the extent of its capital contribution.*

     The provision for income taxes for the six months ended June 30, 1998 was
approximately 10% as compared to 0% for the corresponding period in 1997. The
increase in the estimated annual tax rate is due primarily to state income taxes
relating to the Greenville Facility coupled with the federal alternative minimum
tax.

LIQUIDITY AND CAPITAL RESOURCES

     Total cash and cash equivalents plus short-term investments increased to
$49.3 million at June 30, 1998, compared to $47 million at December 31, 1997.
The increase in cash was primarily due to a $30 million investment in Combustion
Systems by Enron Ventures Corporation for a 15% ownership in Combustion Systems,
largely offset by early payments of $40 million on the Chase Term Debt Facility
(See Note 7 to Unaudited Condensed Consolidated Financial Statements),  coupled
with a net increase in various working capital items associated with the
Pharmaceutical business.  During the quarter ended June 30, 1998, the Company
made early payments of $20 million on the Chase Term Debt Facility.

     During the past several years, the Company has obtained various term loans
and lines of credit to fund capital purchases and working capital needs. On July
31, 1997 in conjunction with the Acquisition of the Greenville Facility, the
Company, a syndicate of Banks led by Chase Manhattan Bank ("Chase") entered into
a Credit 

                                       15
<PAGE>
 
Agreement. In the second quarter of 1998 this Credit Agreement was amended,
pursuant to which Catalytica Pharmaceuticals could borrow up to an aggregate of
$175,000,000 (the "Debt Facilities"). The Debt Facilities consisted of a senior
secured term loan facility (the "Term Debt Facility") in an aggregate principal
amount of $75,000,000 and a senior secured revolving facility (the "Revolving
Debt Facility") in an aggregate principal amount of $100,000,000. The Term Debt
Facility will mature on December 31, 2002, and amortizes in quarterly
installments commencing on December 31, 1999 in aggregate annual amounts of (i)
$10,000,000 in the fourth quarter of 1999, (ii) $15,000,000 in the year 2000,
(iii) $20,000,000 in the year 2001, and (iv) $30,000,000 in the year 2002. The
Revolving Debt Facility matures on December 31, 2002. As of June 30, 1998,
$10,000,000 was outstanding under the Revolving Debt Facility and $75,000,000
was outstanding under the Term Debt Facility. In the first half of 1998, the
Company made early payments of $40 million on the original Chase Term Debt
Facility. During the quarter ended June 30, 1998, the Company made early
payments of $20 million on the original Chase Term Debt Facility. Because of
these early payments and the amendment of the Debt Facilities which includes
changes to the amortization schedule, there are no remaining amounts owed in
1998. As of June 30, 1998, the Company was in compliance with various covenants
and other restrictions contained in the Chase Debt Agreement and believes that
it will remain in compliance.*

     In the second quarter of 1998, the Company entered into an interest rate
swap, derivative transaction in order to better match the Company's floating-
rate interest income on its cash equivalents and short-term investments with its
fixed-rate interest expense on its long-term debt, and to diversify a portion of
the Company's exposure away from fluctuations in short-term interest rates.
The net effect of the interest rate swap was to fix the LIBOR benchmark rate
used to calculate the Company's borrowing cost at 5.9% for 4 years on
$50,000,000 of the Term Debt Facility.

     The Company's operations to date have required substantial amounts of
cash. As part of the financing of the Acquisition of the Greenville Facility,
Catalytica Pharmaceuticals incurred approximately $125 million of long-term
indebtedness, of which $75 million was outstanding as of June 30, 1998, plus
$10 million of short-term indebtedness under the Revolving Debt Facility as of
June 30, 1998. The Company and its subsidiary Catalytica Advanced Technology
have guaranteed this indebtedness. As a result of this increased leverage,
Catalytica Pharmaceuticals' principal and interest obligations have increased
substantially. The degree to which Catalytica Pharmaceuticals is leveraged
could adversely affect Catalytica Pharmaceuticals' and the Company's ability
to obtain additional financing for working capital, acquisitions or other
purposes and could make Catalytica Pharmaceuticals and the Company more
vulnerable to economic downturns and competitive pressures. The Company's
future capital requirements will depend on many factors, including Catalytica
Pharmaceuticals level of business beyond the Supply Agreement with Glaxo
Wellcome, the rate of commercialization of the Company's catalytic combustion
systems, and the need to expand manufacturing capacity for pharmaceutical or
combustion systems business.* The Company expects to spend approximately $30
million to $40 million during 1998 for capital expenditures primarily at
Catalytica Pharmaceuticals.* Because of its cash position of $49.3 million
(including short-term investments) and its available line of credit of $100
million as of June 30, 1998 coupled with the anticipated cash flow from
operations in 1998, the Company believes that it has adequate funds to meet
its working capital needs and debt repayment obligations for at least the next
12 months.*

RISK FACTORS

     HISTORY OF OPERATING LOSSES AND UNCERTAINTY OF FUTURE RESULTS.  The
Company's business had not been profitable until the quarter ended September 30,
1997.  As of June 30, 1998, the Company had an accumulated deficit of $38.6
million.  To achieve continued profitable operations, Catalytica must
successfully manage the operations of the pharmaceutical manufacturing facility
located in Greenville, North Carolina (the "Greenville Facility"), and, to a
lesser extent, successfully develop, manufacture, introduce and market or
license its combustion systems and catalytic processes.* The Company began
manufacturing, marketing and selling pharmaceutical intermediates in 1994.  As a
result of the acquisition of the Greenville Facility in 1997, it has
substantially increased its manufacturing of pharmaceutical products.

     The additional facilities, employees and business volumes resulting from
the acquisition of the Greenville Facility from Glaxo Wellcome in the third
quarter of Fiscal 1997 (the "Acquisition") substantially increased the expenses
and working capital requirements and placed substantial burdens on the Company's
management resources.  Furthermore, the success of the Acquisition and the
Company's future results depend, in significant part, on the levels 

                                       16
<PAGE>
 
of manufacturing business developed by Catalytica Pharmaceuticals.* In the event
Catalytica Pharmaceuticals does not obtain additional new customers, which could
involve additional business from Glaxo Wellcome, on terms sufficient to offset
the costs associated with operating and maintaining the Greenville Facility, and
with servicing the debt incurred in connection with the acquisition of the
Greenville Facility, the Company's consolidated results of operations and
financial condition would be materially adversely affected.

     Due to the size of the Acquisition, the results of operations of Catalytica
Pharmaceuticals have a material effect on the consolidated results of operations
of the Company, and the results of operations of the Company's other businesses
will be insignificant for 1998.*   The anticipated revenues from the Supply
Agreement entered into with Glaxo Wellcome are expected to allow the Company to
achieve profitable operations for Catalytica Pharmaceuticals for 1998.* After
1998, Catalytica Pharmaceuticals' profitability will depend on its success and
timing in obtaining new customers, including possible new agreements with Glaxo
Wellcome.*  Manufacturing at the Greenville Facility is conducted in three
distinct operations: Chemical Manufacturing Operations ("CMO"), Pharmaceutical
Product Operations ("PPO") and Sterile Product Operations ("SPO"). There is
substantial excess manufacturing capacity immediately available at the PPO and
SPO facilities, but because of the long lead times required to obtain necessary
regulatory approvals to manufacture pharmaceutical and sterile products at these
facilities, Catalytica Pharmaceuticals does not anticipate additional
significant revenue from such facilities until late 1998 or 1999 at the
earliest.*  Catalytica Pharmaceuticals' inability to fill additional available
capacity or to reduce costs in conjunction with lower levels of capacity
utilization would have a material adverse effect on the Company's results of
operations.  See "Management's Discussion and Analysis of Financial Condition
and Results of Operations."

     The Company anticipates its operating results will fluctuate from quarter
to quarter as a result of differences in the amount and timing of expenses
incurred and revenues received.  In particular, the Company's operating results
are affected by the size and timing of receipt of orders for and shipments of
its pharmaceuticals products, as well as the amount and timing of payments and
expenses under the Company's research and development contracts.

     MANAGEMENT OF GROWTH; LIMITATION OF EXISTING INFORMATION SYSTEMS.  The
Company's business is currently experiencing a period of growth that has placed
and is expected to continue to place a significant strain on the Company's
personnel and resources.  The Company's ability to manage future growth, if any,
will depend on its ability to continue to implement and improve operational,
financial and management information and control systems on a timely basis,
together with maintaining effective cost controls.  In particular the Company's
existing information system is not yet completely Year 2000 compliant, as a
result, the Company is continuing to modify the system.  To support any future
growth, the Company will need to hire more sales, marketing, support and
administrative personnel, and expand customer service capabilities.*
Competition for the necessary personnel in the Company's industry is intense.
There can be no assurance that the Company will be able to attract and retain
the necessary personnel or that it will be able to satisfy customer demand in a
timely fashion and satisfactorily support its customers and operations.

     RELIANCE ON RELATIONSHIP WITH GLAXO WELLCOME.  Catalytica Pharmaceuticals
estimates that aggregate payments by Glaxo Wellcome under the Supply Agreement,
as amended, which commenced on August 1, 1997, and was expanded in the second
quarter of 1998, will total approximately $850 million, which include guaranteed
minimum payments plus the cost of raw materials.* The annual level of minimum
payments declines significantly after 1998, but is expected to continue to
represent a significant source of revenue for Catalytica Pharmaceuticals.*
Results for Catalytica Pharmaceuticals business is substantially dependent on
its Supply Agreement with Glaxo Wellcome during 1998 and 1999, and will continue
to be dependent on Glaxo Wellcome in part thereafter until the end of the term
of the Supply Agreement.*  Catalytica Pharmaceuticals' business and the
Company's consolidated results of operations would be adversely affected if
Catalytica Pharmaceuticals does not successfully perform its obligations under
the Supply Agreement.  This could result in increased costs to the Company or in
possible termination of the Supply Agreement by Glaxo Wellcome.*

     DEPENDENCE ON KEY PERSONNEL.  The Company's success is dependent on the
retention of principal members of its management and scientific staff and on the
ability to continue to attract, motivate and retain additional key personnel.
Competition for such key personnel is intense, and the loss of the services of
key personnel or the failure to recruit necessary additional personnel could
have a material adverse effect on the Company's operations and on its research
and development efforts.  The Company does not have non-competition 

                                       17
<PAGE>
 
agreements with any of its key employees. The Company's expansion into areas and
activities requiring additional expertise, such as manufacturing, marketing and
distribution, have placed increased demands on the Company's resources. These
activities require the addition of new personnel with expertise in these areas
and the development of additional expertise by existing personnel. Any failure
on the part of Catalytica Pharmaceuticals to attract or retain necessary
personnel would have a material adverse effect on the Company's consolidated
results of operations.

     UNCERTAINTIES RELATED TO COMBUSTION SYSTEMS BUSINESS.  The Company, through
its subsidiary Catalytica Combustion Systems, Inc. ("Combustion Systems"), and
the GENXON joint venture, is still conducting research and development on its
combustion systems.  Prior to commercialization of its combustion systems, the
Company's products will be required to undergo rigorous testing by turbine
manufacturers.  Ultimate sales of the Company's combustion system products will
depend upon the acceptance and use of the Company's technology by a limited
number of turbine manufacturers and the Company's ability to enter into
commercial relationships with these manufacturers.*  The Company's subsidiary,
Combustion Systems, is currently working with leading turbine manufacturers,
including: Pratt & Whitney Canada, Inc., General Electric, Allison Engine Co., a
subsidiary of Rolls Royce, and Solar, a subsidiary of Caterpillar, Inc.  In
addition, through its joint venture company GENXON, Combustion Systems is
developing complete combustor systems for AGC, to be used on small Kawasaki
Heavy Industries  turbines for mobile cogeneration applications.  GENXON is also
developing complete combustor systems utilizing Catalytica's combustion
technology for end users to be retrofitted on older out-of-warranty turbines no
longer supported by OEM's.  Neither the Company, its subsidiary Combustion
Systems, nor the joint venture company GENXON have formal long-term agreements
in place with many of these companies.  The Company's ability to complete
research and development and introduce commercial systems for these markets
could be adversely affected if any of these companies terminated its
relationship with the Company or GENXON.  If such terminations occurred, there
is no assurance as to whether the Company could enter into a similar
relationship with another manufacturer.

     The Company currently has limited manufacturing and marketing capability
for its combustion products, and to the extent that the Company's  existing
facilities are inadequate, the Company will be required to develop or acquire
manufacturing capability.  In order to market any of its combustion system
products, the Company will be required to develop marketing capability, either
on its own or in conjunction with others.  There can be no assurance that the
Company will be able to manufacture its products successfully or develop an
effective marketing and sales organization.  In addition, some of the Company's
combustion systems and processes are expected to be sold as components of large
systems such as natural gas turbines for electric power plants.*  Accordingly,
the rate of adoption of the Company's systems and processes may depend in part
on economic conditions that affect capital investment decisions, as well as the
regulatory environment.*  There can be no assurance that the Company's
combustion products will be economically attractive when compared to competitive
products.

     In October 1996 Combustion Systems and Woodward Governor Company formed a
Delaware limited liability company in connection with a 50/50 joint venture to
serve the gas turbine retrofit market for installed, out-of-warranty engines.
The new company, GENXON/(TM)/ Power Systems, LLC ("GENXON"), will initially
upgrade the combustion systems of installed turbines with XONON which is
designed to reduce emissions and permit greater asset utilization for both power
generation and mechanical drive markets.  GENXON plans to deliver an integrated
product which includes Combustion Systems' system for ultra low NOx emissions
and Woodward's control systems.* Unlike Catalytica Combustion Systems' efforts
to date, which have focused only on the design of the catalyst assembly, GENXON
is developing entire combustion systems.  The development of complete combustion
systems by GENXON to serve the retrofit market will require the design of new
combustion chambers to be retrofitted on existing turbines.  This new combustion
chamber will incorporate a XONON catalyst.*  There can be no assurance that
GENXON will be successful in developing new combustion chambers that will work
in lieu of the current design that does not incorporate a catalyst.  There can
be no assurance that GENXON's products will be economically attractive when
compared to competitive products.

     The initial capital commitment of the GENXON joint venture partners was $10
million--$2 million from Combustion Systems and $8 million from Woodward--
payable over time as the funds were required by the joint venture.  This initial
capital commitment of $10 million was reached during the third quarter of 1997.
Continued funding of the joint venture beyond the initial $10 million commitment
has occurred on a 50/50 basis with each joint 

                                       18
<PAGE>
 
venture partner contributing $1.4 and $2.6 million, respectively, for the three
and six months ended June 30, 1998, bringing the total investment in the joint
venture to $19.95 million to date. Combustion Systems recognized its 50% share
of GENXON losses, of $2.3 million, of which $1.15 million was Combustion Systems
50% of GENXON's loss for the three months ended June 30, 1998, and $4.6 million,
of which $2.3 million was Combustion Systems 50% of GENXON's loss for the six
months ended June 30, 1998. Accordingly, losses on the joint venture were
recognized in the results of operations. The Company expects to make additional
capital contributions to the joint venture during the remainder of fiscal 1998
and anticipates GENXON will incur additional losses.* The Company will record
its share of these losses to the extent of its capital contribution. Although
Combustion Systems and Woodward intend to continue the funding of this joint
venture, neither joint venture partner is contractually required to make further
capital infusions. If the Company desired to complete any projects being
developed by the joint venture, the Company could be required to fund the
projects itself if Woodward decides not to make any additional capital
contributions to GENXON.* If such an event were to occur, it could have an
adverse effect on the Company's results of operations and financial condition.
See "Management's Discussion and Analysis of Financial Condition and Results of
Operations."

     RISK OF PRODUCT LIABILITY.  Although Catalytica Pharmaceuticals intends to
seek indemnification from its customers for any product liability claims that
may result from the pharmaceutical products it produces, there can be no
assurance that Catalytica Pharmaceuticals will not ultimately be found liable
for any product liability claims regarding products it manufactures.  Catalytica
Pharmaceuticals expects it will be required to indemnify its customers for
product liability claims if a manufacturing defect results in injury.  There can
be no assurance that Catalytica Pharmaceuticals will be able to obtain or
maintain product liability insurance in the future on acceptable terms or with
adequate coverage against potential liabilities.  If Catalytica Pharmaceuticals
is found liable in a product liability claim and the Company does not have
adequate product liability insurance or indemnification, the Company's
consolidated results of operations could be materially adversely effected.
Additionally, under the Supply Agreement, Catalytica Pharmaceuticals is
obligated to maintain $100,000,000 of product liability insurance.  If
Catalytica Pharmaceuticals does not meet this requirement, it would be
considered a default under the Supply Agreement.

     HAZARDOUS MATERIALS AND ENVIRONMENTAL MATTERS.  The Company's research and
development activities and fine chemicals manufacturing involve the use of many
hazardous chemicals.  The use of such chemicals has significantly increased as a
result of the acquisition of the Greenville Facility.  The Company is subject to
extensive federal, state and local laws and regulations governing the use,
manufacture, storage, handling and disposal of such materials and associated
waste products.  The Company believes that its properties and operations comply
in all material respects with applicable environmental laws; however, the risk
of environmental liabilities cannot be completely eliminated.  Public awareness
of environmental issues has increased the impact of such laws on the conduct of
manufacturing operations and ownership of property.  Any failure by the Company
to comply with present or future environmental laws could result in cessation of
portions or all of the Company's operations, impositions of fines, restrictions
on the Company's ability to carry on or expand its operations, significant
expenditures by the Company to comply with environmental laws and regulations,
and/or liabilities in excess of the resources of the Company.  The Company has
environmental impairment insurance with regard to first party and third party
liability in the amount of $25,000,000 (with a $1,000,000 retention) with
respect to the Greenville Facility only.  There can be no assurance that the
Company will not be required to make renovations or improvements to comply with
environmental laws and regulations in the future.  The Company's operations,
business or assets could be materially adversely affected in the event such
environmental laws or regulations require the Company to modify current
facilities substantially or otherwise limit the Company's ability to conduct or
expand its operations.

     Catalytica Pharmaceuticals expects that significant expenditures may be
incurred at the Greenville Facility as a result of new environmental regulations
currently under consideration.  The United States Environmental Protection
Agency  (the "EPA") is considering new regulations for the pharmaceutical
industry under the authority of the federal Clean Air Act and Clean Water Act.
These proposed regulations would require the installation of "Maximum Achievable
Control Technology" for certain hazardous air pollutant emissions sources
("Pharmaceutical MACT") and could potentially require the installation of
additional pretreatment systems for wastewater discharges.*  The EPA is also
considering changes to its particulate matter emissions regulations as well as
regulation of certain ozone precursor emissions.*  As these rules are in the
early stages of consideration by the EPA, and as there can be 

                                       19
<PAGE>
 
no assurance of their adoption, the additional cost of complying with such
regulations cannot be determined at this time. There can be no assurance that
Catalytica Pharmaceuticals will not be required to make additional renovations
or improvements to comply with environmental laws and regulations in the future.
Catalytica Pharmaceuticals' operations, business and assets could be materially
adversely affected in the event such environmental laws or regulations require
Catalytica Pharmaceuticals to modify the current Greenville Facility
substantially or otherwise limit Catalytica Pharmaceuticals' ability to conduct
or expand its operations.

     CURRENT AND POTENTIAL ENVIRONMENTAL CONTAMINATION AT CATALYTICA
PHARMACEUTICALS' TWO SITES.  Glaxo Wellcome has been working with the EPA and
the North Carolina Department of Environment and Natural Resources (the
"NCDENR") to investigate, identify and remediate contamination in the soil and
groundwater at the Greenville Facility now owned by Catalytica Pharmaceuticals.
This investigation, carried out pursuant to the federal Resource Conservation
and Recovery Act, has identified 17 different areas of the Greenville Facility
where contamination has or may have occurred.  Of these 17 areas, at least six
have been identified as requiring further investigation and remediation by
NCDENR ("Site Contamination").  Contaminants found in the soil and groundwater
at the Greenville Facility include solvents, petroleum hydrocarbons and
pesticides. As the new owner of the Greenville Facility, Catalytica
Pharmaceuticals has become legally liable for such contamination.
Notwithstanding such legal liability, Glaxo Wellcome has agreed to be primarily
liable for and to perform, at its cost, the remediation required by law for
contamination of the soil and groundwater existing at the Greenville Facility as
of the Closing.  The cost and extent of remediation to be required at the
Greenville Facility is currently unknown.  The Environmental Agreement with
Glaxo Wellcome also requires Catalytica Pharmaceuticals to provide access to the
Greenville Facility and certain facility services as required for the
remediation, subject to reimbursement by Glaxo Wellcome.  However, there can be
no assurance that the Company or Catalytica Pharmaceuticals will not incur
unreimbursed costs or suffer an interference with ongoing operations as a result
of Glaxo Wellcome's remediation activities or the existence of contamination at
the Greenville Facility.  In addition, the Company's future development of the
Greenville Facility may be limited by the existence of contamination or Glaxo
Wellcome's remediation activities.  There also can be no assurance that
Catalytica Pharmaceuticals' ongoing operations at the Greenville Facility will
not cause additional contamination.  The determination of the existence and cost
of any such additional contamination contributed by Catalytica Pharmaceuticals
of the Company could involve costly and time-consuming negotiations and
litigation.  Furthermore, any such contamination caused by Catalytica
Pharmaceuticals or the Company could materially adversely affect the  business,
results of operations and financial condition of Catalytica Pharmaceuticals and
the consolidated results of operations and financial condition of the Company.

     In addition, a moderate amount of asbestos containing material ("ACM") is
present at the Greenville Facility.  Catalytica Pharmaceuticals believes that
the ACM, in its present condition, does not require abatement.  Abatement will
only be required if and as renovations are performed in those areas containing
ACM.  Catalytica Pharmaceuticals cannot presently predict whether, when or to
what extent it may need or desire to renovate areas of the Greenville Facility
containing ACM.  However, should such renovations be necessary, the additional
costs could be substantial.

     The Company through a subsidiary leases the land on which its Bayview
facility in East Palo Alto, California is located from Rhone Poulenc, Inc.,
("Rhone Poulenc").  The past activities of Rhone Poulenc's predecessor caused
significant soil and groundwater contamination of the facility and a down
gradient area located along the San Francisco Bay.  Consequently, the site is
subject to a clean up and abatement order issued by the Bay Area Regional Water
Quality Control Board ("RWQCB") which currently requires stabilization,
containment and monitoring of the arsenic and volatile organic contamination at
the site and surrounding areas.  The ground lease between Rhone Poulenc and the
Company includes an indemnity by Rhone Poulenc against any costs and liabilities
that the Company might incur to fulfill the RWQCB order and to otherwise address
the contamination that is the subject of the order.  The Company also has
obtained an indemnification from Novartis (the immediately preceding
owner/operator of the facility) against any costs and liability the Company may
incur with respect to any contamination caused by Novartis' operations.
However, there can be no assurance that the Company will not be held responsible
with respect to the existing contamination or named in an action brought by a
governmental agency or a third party because of such contamination.  If the
Company is held responsible and it has contributed to the contamination, it will
be liable for any damage to third parties, and will be required to indemnify
Rhone Poulenc and Novartis for any additional clean up costs or liability they
may incur, with respect to the contamination caused by the Company.  The
determination of the existence and additional cost of any such incremental
contamination 

                                       20
<PAGE>
 
contribution by the Company could involve costly and time-consuming negotiations
and litigation. Further, any such incremental contamination by the Company or
the unenforceability of either of the indemnity agreements described above could
materially adversely affect the Company's business and results of operations.

     CATALYTICA PHARMACEUTICALS' COMPLIANCE WITH FDA REGULATIONS.  Many of the
fine chemicals products Catalytica Pharmaceuticals manufactures, or will
manufacture in the future, and the final drug products in which they are used
are subject to regulation for safety and efficacy by the FDA and foreign
regulatory authorities before such products can be commercially marketed.  The
process of obtaining regulatory clearances for marketing is uncertain, costly
and time consuming.  Catalytica Pharmaceuticals cannot predict how long the
necessary regulatory approvals will take or if its customers will ever obtain
such approval for their products.  To the extent Catalytica Pharmaceuticals'
customers do not obtain the necessary regulatory approvals for marketing new
products, Catalytica Pharmaceuticals' fine chemicals product sales will be
adversely affected.

     Products manufactured by Catalytica Pharmaceuticals at the Greenville
Facility require Catalytica Pharmaceuticals to comply with the FDA's current
Good Manufacturing Practices ("cGMP") regulations, and certain of Catalytica
Pharmaceuticals' customers, including Glaxo Wellcome, also require Catalytica
Pharmaceuticals to adhere to cGMP regulations, even if not required by the FDA.
In complying with cGMP regulations, manufacturers must continue to expend time,
money and effort in production, record keeping and quality control to ensure
that the product meets applicable specifications and other requirements.  The
FDA periodically inspects drug-manufacturing facilities to ensure compliance
with applicable cGMP requirements.  Failure to comply subjects the manufacturer
to possible FDA action, such as suspension of manufacturing.  The FDA also may
require the submission of any lot of the product for inspection and may restrict
the release of any lot that does not comply with FDA regulations, or may
otherwise order the suspension of manufacture, recall or seizure.  Failure of
Catalytica Pharmaceuticals' customers to obtain and to maintain FDA clearance
for marketing of the products manufactured by Catalytica Pharmaceuticals, or
failure of Catalytica Pharmaceuticals to comply with cGMP regulations as
required by the FDA or Catalytica Pharmaceuticals' customers, would have a
material adverse effect on the Company's results of operations.

     INFLUENCE OF ENVIRONMENTAL REGULATIONS ON RATE OF COMMERCIALIZATION.  The
rate at which industrial companies adopt the Company's catalytic combustion
systems will be heavily influenced by the enactment and enforcement of
environmental regulations at the federal, state and local levels.*  Current
federal law governing air pollution generally does not mandate the specific
means for controlling emissions, but instead, creates ambient air quality
standards for individual geographic regions to attain through individualized
planning on a regional basis in light of the general level of air pollution in
the region.  Federal law requires state and local authorities to determine
specific strategies for reducing emissions or specific pollutants.  Among other
strategies, state and local authorities in all areas which do not meet ambient
air quality standards must adopt performance standards for all major new and
modified sources of air pollution.  The more polluted the air in a particular
region has become, the more stringent such controls must be.  The Company's
revenues will depend, in part, on the standards, permit requirements and
programs these state and local authorities promulgate for reducing emissions
(including emissions of NOx) addressed by the Company's combustion systems.*
Demand for the Company's systems and processes will be affected by how quickly
the standards are implemented and the level of reductions required.*  Certain
industries or companies may successfully delay the implementation of existing or
new regulations or purchase or acquire emissions credits from other sources,
which could delay or eliminate their need to purchase the Company's systems and
processes.  Moreover, new environmental regulations may impose different
requirements which may not be met by the systems and processes being developed
by Catalytica or which may require costly modifications of the Company's
products.  The United States Congress is currently reviewing existing
environmental regulations.  There can be no certainty as to whether Congress
will amend or modify existing regulations in a manner that could have an adverse
effect on demand for the Company's combustion system products.

     COMPETITION AND TECHNOLOGICAL CHANGE.  There are numerous competitors in a
variety of industries in the United States, Europe and Japan that have
commercialized and are working on technologies that could be competitive with
those under development by the Company, including both catalytic and other
technological approaches. The Company's competitors may develop technologies and
systems and processes that are more effective than those being developed by the
Company or that would render the Company's technology and systems and processes
less competitive or obsolete.  In the market for fine chemicals used in
pharmaceutical products and in the market for final dosage form of
pharmaceutical products, the Company faces its primary competition from

                                       21
<PAGE>
 
pharmaceutical companies that manufacture their own products and from other fine
chemicals manufacturers such as Lonza AG and DSM Fine Chemicals. In the
combustion systems market, the Company faces its primary competition from large
gas turbine power generation manufacturers, such as General Electric Co.
("General Electric"), Allison Engine Company ("Allison") and Solar Turbines
Incorporated ("Solar"), each of which is developing competing DLN systems for
their own turbines. Many of the Company's competitors in the combustion systems
market are also potential customers of the Company, and the Company expects to
rely on these potential customers to help commercialize its products.* Most of
these competitors have greater research and development capabilities, financial
resources, managerial resources, marketing experience and manufacturing
experience than the Company. If these companies are successful in developing
such products, the Company's ability to sell its systems and processes would be
materially adversely affected. Further, since many of the Company's competitors
are existing or potential customers, the Company's ability to gain market share
may be limited.

     PATENTS AND INTELLECTUAL PROPERTY.  The Company has an active program of
pursuing patents for its inventions in the United States and in markets
throughout the world relevant to its business areas.  The Company has at least
37 United States patents and 14 pending United States patent applications, and
at least 91 foreign patents and patent applications.

     The Company's success will depend on the ability to continue to obtain
patents, protect trade secrets and operate without infringing on the proprietary
rights of others in the United States and other countries.  There can be no
assurance that the Company's patent applications will result in the issuance of
any patent, that any of the Company's existing patents or any patents that may
be issued in the future will provide significant proprietary protection, that
any such patents will be sufficiently broad to protect the Company's technology,
or that any such patents will not be challenged, circumvented or invalidated.
There can also be no assurance that the patents of others will not have an
adverse effect on the Company.  Others may independently develop similar systems
or processes or design around patents issued to the Company.  In addition, the
Company may be required to obtain licenses to patents or other proprietary
rights.  The Company cannot assure that any licenses required under any such
patents or proprietary rights would be made available on terms acceptable to the
Company, if at all.  If Catalytica requires and does not obtain such licenses,
it could encounter delays in system or process introductions while it attempts
to design around such patents, or it could find that the development,
manufacture, sale or licensing of systems or processes requiring such licenses
could be foreclosed.  The Company could incur substantial costs in defending
itself or its licensees in litigation brought by others or prosecuting
infringement claims against third parties.  The Company could incur substantial
costs in interference proceedings declared by the United States Patent and
Trademark Office in connection with one or more of the Company's or third
parties' patents or patent applications, and those proceedings could also result
in an adverse decision as to the priority of the Company's inventions.  The
Company also protects its proprietary technology and processes in part by
confidentiality agreements with its collaborative partners, employees and
consultants.  There can be no assurance that these agreements will not be
breached, that the Company will have adequate remedies for any breach, or that
the Company's trade secrets will not otherwise become known or be independently
discovered by competitors.

     CONCENTRATION OF OWNERSHIP.  Morgan Stanley Capital Partners III, L.P. and
two affiliated funds (collectively, "MSCP") beneficially own approximately 32%
of the voting control of the Company and 47% of the outstanding capital stock of
the Company as of June 30, 1998.  As a result, MSCP is able to exercise
significant influence over all matters requiring stockholder approval, including
the election of directors and approval of all significant corporate transactions
such as any merger, consolidation or sale of all or substantially all of the
Company's assets.  The Company has granted to MSCP certain contractual rights,
including representation on the Company's Board of Directors and committees of
the Board of Directors, that will give MSCP additional rights to participate in
certain actions to be taken by the Company.  Such concentration of ownership and
contractual rights may have the effect of delaying, deferring or preventing a
change of control of the Company.  The sale by MSCP of shares of the Company's
capital stock could constitute a change of control under the Company's credit
agreement, which would trigger a default of the agreement.  MSCP has agreed not
to trigger a change of control under the credit agreement.  In addition, such
concentration of ownership and contractual rights could allow MSCP to prevent
significant corporate transactions.

                                       22
<PAGE>
 
    PART II - OTHER INFORMATION

    Item 4.     SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

   On June 16, 1998, at the annual stockholder's meeting, a quorum of
stockholders of the Company approved the following proposals:  (1) the re-
election of the Board of Directors;  (2) amendment to the Company's 1992
Employee Stock Purchase Plan to increase the number of shares of Common Stock
reserved for issuance thereunder by 1,500,000 shares;  (3) amendment to the
Company's 1992 Stock Option Plan to increase the number of shares of Common
Stock reserved for issuance thereunder by 2,000,000 shares;  and (4)
ratification of the appointment of Ernst & Young LLP to serve as the Company's
independent auditors for the ensuing year.

   Proposal 1.   Election of Directors

<TABLE>                      
<CAPTION>
             DIRECTOR                                       FOR               ABSTAIN
             --------                                       ---               -------     
             <S>                                     <C>                 <C>
             James A. Cusumano                               35,572,813             30,043
             Utz Felcht                                      34,495,275          1,107,581
             Richard Fleming                                 35,559,736             43,120
             Alan Goldberg                                   35,556,283             36,573
             Howard I. Hoffen                                35,565,257             37,599
             Ricardo B. Levy                                 35,571,613             31,243
             Ernest Mario                                    35,569,968             32,888
             John A. Urquhart                                34,757,909            844,947
</TABLE>


    Proposal 2.  Amendment to the Company's 1992 Employee Stock Purchase Plan to
increase the number of shares of Common Stock reserved for issuance thereunder
by 1,500,000 shares

<TABLE>
<CAPTION>
                                                                                              BROKER
                                                                                              ------        
                 FOR                           AGAINST                 ABSTAIN               NON-VOTE
                 ---                           -------                 -------               --------       
<S>                                     <C>                     <C>                     <C>
             26,699,907                        357,522                  73,933               8,471,494
</TABLE>
                                                                                
   Proposal 3. Amendment to the Company's 1992 Stock Option Plan to increase the
number of shares of Common Stock reserved for issuance thereunder by 2,000,000
shares

<TABLE>
<CAPTION>
                                                                                              BROKER
                                                                                              ------        
                 FOR                           AGAINST                 ABSTAIN               NON-VOTE
                 ---                           -------                 -------               --------       
<S>                                     <C>                     <C>                     <C>
              26,070,695                        983,159                 77,508               8,471,494
</TABLE>
                                                                                
   Proposal 4. Ratification of Appointment of Independent Auditors

<TABLE>
<CAPTION>
                                                                                              BROKER
                                                                                              ------        
                 FOR                           AGAINST                 ABSTAIN               NON-VOTE
                 ---                           -------                 -------               --------       
<S>                                     <C>                     <C>                     <C>
             35,522,907                         48,675                  31,274                    0
</TABLE>
                                                                                

    Item 5.                     OTHER INFORMATION

   Pursuant to the Company's Bylaws, stockholders who wish to bring matters or
propose nominees for director at the Company's 1999 annual meeting of
stockholders must provide specified information in writing to the secretary of
the Company not less than the thirty (30) days nor more than sixty (60) days
prior to the first anniversary of the 1998 annual meeting (i.e., June 17, 1999),
unless such matters are included in the Company's proxy statement pursuant to
Rule 14a-8 under the Securities Exchange Act, as amended.

                                       23
<PAGE>
 
    Item 6.                    EXHIBITS AND REPORTS ON FORM 8-K

   (a)        Exhibits

             *10.1 Amendment No. 1 to Supply Agreement between Glaxo Wellcome 
                   Inc. and Catalytica Pharmaceuticals, Inc. dated May 28, 1998

              10.2 Effectiveness Agreement among Catalytica, Inc. Catalytica
                   Pharmaceuticals, Inc. and The Chase Manhattan Bank dated
                   June 4, 1998, including Exhibit A, $175,000,000 Amended and
                   Restated Credit Agreement

              27.1 Financial Date Schedule


              * Confidential Treatment has been requested for certain portions 
        of this Agreement.
                
    (b)       Reports on Form 8-K

   The Company filed no reports on Form 8-K during the quarter ended June 30,
1998.

   All information required by other items in Part II is omitted because the
items are inapplicable, the answer is negative or substantially the same
information has been previously reported by the registrant.

                                       24
<PAGE>
 
                                CATALYTICA, INC.

                                   SIGNATURES

  Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.


Date: August 14, 1998
                                    CATALYTICA, INC.
                                    (Registrant)


                                              /s/ Lawrence W. Briscoe
                                    By: _________________________________
                                               Lawrence W. Briscoe
                                            Vice President and Chief
                                               Financial Officer

                                    Signing on behalf of the
                                    registrant and as principal
                                    financial officer

                                       25

<PAGE>

                                                                    EXHIBIT 10.1
 
                                              CONFIDENTIAL TREATMENT REQUESTED.
                                              OMITTED PORTIONS HAVE BEEN FILED
                                              SEPARATELY WITH THE COMMISSION.


                      AMENDMENT NO. 1 TO SUPPLY AGREEMENT

     This Amendment No. 1 to Supply Agreement (the "Amendment") is entered into
by and between Glaxo Wellcome Inc. ("GWI") and Catalytica Pharmaceuticals, Inc.
("Supplier") as of May 28, 1998, and amends that certain Supply Agreement
entered into by and between Supplier and GWI effective as of July 31, 1997
(together with all exhibits and schedules thereto, the "Agreement").

                                    RECITALS
                                    --------
     A.   Supplier is modifying the production capacity of Module 2 of Building
3 in the Primary Facility.

     B.   GWI wishes to amend the Agreement to reserve additional reactor
capacity in the Primary Facility during 1998 and 1999, and Supplier is agreeable
to reserving such additional capacity for GWI.

     C.   GWI may have sufficient requirements to request the Supplier to
produce [*    *    *] in the pilot plant (Module 7 of Building 3).

     THEREFORE, the parties hereto agree as follows:

     1.   All capitalized terms not defined in this Amendment shall have the
meanings given to them in the Agreement.

                                       1
<PAGE>
 
                                              CONFIDENTIAL TREATMENT REQUESTED.
                                              OMITTED PORTIONS HAVE BEEN FILED
                                              SEPARATELY WITH THE COMMISSION.

     2.   Supplier and GWI acknowledge that Supplier is presently modifying its
manufacturing capabilities in Module 2 of Building 3 in the Primary Facility
pursuant to Contract Number 98003 made and entered into as of January 29, 1998
(the "Services Agreement"), by and between GWI and Supplier (the "First
Modification").  Supplier has also agreed to undertake and is undertaking, at
its expense, an additional modification of Module 2 in the Primary Facility,
which modification involves adding a new vessel and will result in an additional
[*    *] Reactor Gallon capacity (the "Second Modification").  Both the First
Modification and the Second Modification are expected to become fully
operational for production of saleable product on August 15, 1998.  Supplier
agrees that upon completion of the two Modifications, it will be able to provide
GWI with an additional [ * ] Reactor Gallons from August 15, 1998 through the
end of 1998 and an additional [ * ] Reactor Gallons for 1999.  These incremental
Reactor Gallons are included in the revised aggregate Reactor Gallons reserved
as set forth in Paragraph 6 below.

     3.   As agreed to in the Services Agreement, the First Modification is
expected to increase the Primary Facility's production capacity for finished [ *
*  *  ] to a new total of [*    *] metric tons per year.  GWI and  Supplier have
agreed that the best estimate of the Primary Facility's production capacity for
finished [ *    *    *  ] when the Second Modification is completed, and
assuming the Profile Plant as amended hereunder, would be [ *  ] metric tons per
year.  However, GWI and Supplier acknowledge uncertainty will remain as to the
actual level of annual production capacity for [ *    *    * ] until Supplier
has actual experience with multiple production batches following completion of
the First and Second Modifications.  Therefore, after 90 days of operation
following completion of the First and Second Modifications, the parties agree to
promptly meet and

                                       2
<PAGE>
 
                                              CONFIDENTIAL TREATMENT REQUESTED.
                                              OMITTED PORTIONS HAVE BEEN FILED
                                              SEPARATELY WITH THE COMMISSION.

agree (i) to jointly review the production output data of the modified Module 2,
(ii) to establish a second Reactor Gallon Factor for [  *    *    * ] to be
utilized where the [*    *     *] is routed through Module 2 (the "M-2 RGF"),
and (iii) to revise the linear programming model referenced in Section 2.4(b) of
the Agreement and described in Schedule 2.4(b)(ii) to the Agreement to take into
account the production output of the modified Module 2, a copy of which revised
model shall be deposited in escrow pursuant to the LP Model Software Escrow
Agreement dated as of July 31, 1997.  Should the parties be unable to agree on
the M-2 RGF within 30 days of the end of 90 days of initial production, then
they will select a mutually agreeable independent third party with recognized
expertise in chemical manufacturing.  This independent third party, along with
[*    *    *    *] of Supplier (or such other individual as Supplier may
designate) and [ *     *     * ] of GWI (or such other individual as GWI may
designate) will jointly establish the M-2 RGF.  The decision of two of these
three individuals shall be binding on GWI and Supplier.

     4.   The review of production output data for the modified Module 2 and the
establishment of the M-2 RGF shall not result in any adjustment to the
Guaranteed Revenues set forth in Paragraphs 10 and 11 below.

     5.   In connection with the Modifications, GWI shall have no obligation to
make any payment to Supplier other than (i) as specifically required under the
Services Agreement between GWI and the Supplier, (ii) payments under Article V
of the Agreement for Products produced in the Primary Facility, and (iii)
Guaranteed Revenues under the Agreement as amended herein.  In no event shall
GWI be obligated to make any other payments related to or arising from the First
or Second Modifications, and Supplier shall bear all of those expenses,
including without limitation all expenses for validation, trial runs, and scale-
up production batches.

                                       3
<PAGE>
 
                                              CONFIDENTIAL TREATMENT REQUESTED.
                                              OMITTED PORTIONS HAVE BEEN FILED
                                              SEPARATELY WITH THE COMMISSION.


     6.   Schedule 2.2(b) to the Agreement is hereby revised by deleting the
number [ *    *    * ] where it appears under the heading "Reactor Gallons Per
KG Per Year" for the product [ *    *    * ] and replacing that number with [ *
*     * ].

     7.   Effective upon the determination of the M-2 RGF under Paragraph 3
above, Schedule 2.2(b) to the Agreement shall be amended by deleting the
Schedule, as amended pursuant to Paragraph 6 above, in its entirety and
replacing it with Schedule 2.2.(b) (Revised) attached hereto; provided, that the
final Schedule 2.2(b) (Revised) shall also reflect the M-2 RGF.

     8.   Section 2.4(a) of the Agreement is hereby amended as follows:  the
Reactor Gallon Limitations with respect to the second half of 1998 and calendar
year 1999 as set forth in the table entitled "Contract Reservation" shall be
revised by (i) deleting [ *    *     * ] where it appears under the heading
"1998/2H" and replacing it with the number [  *    *     * ] and (ii) deleting
[*    *     *] where it appears under the heading "1999" and replacing it with
the number [*   *   *].

     9.   Footnote (a) to the table in Section 2.4(a) of the Agreement is hereby
amended as follows:  (i) the period at the end of that text is deleted and the
following text is inserted at the end of the sentence:  "; provided, however,
that the volumes used in the Reactor Gallon calculations for the second half of
1998 must be annualized by multiplying by two (2)."

     10.  Section 6.1 of the Agreement is hereby amended as follows:  (i) the
annual amounts of Guaranteed Revenues set forth in tabular form are revised by
deleting "$166.4 million" in the line beginning "For 

                                       4
<PAGE>
 
                                              CONFIDENTIAL TREATMENT REQUESTED.
                                              OMITTED PORTIONS HAVE BEEN FILED
                                              SEPARATELY WITH THE COMMISSION.

the period ending December 31, 1998" and replacing it with "$173.390 million" 
and by deleting "$94.0 million " in the line beginning "For the period ending 
December 31, 1999" and replacing it with "$113.845 million" and (ii) the 
following shall be inserted at the end of Section 6.1:  "If the Modifications 
are not fully operational for the production of  [  *      *      *  ] by 
August 15, 1998, the annual amounts of Guaranteed Revenues for 1998 and 1999 
shall be reduced by $[  *    *  ] per day for each day on or after August 15, 
1998 falling within that year on which the Modifications are not fully 
operational, and if the Modifications are fully operational for the production
of [  *       *      *  ] prior to August 15, 1998, the annual amount of 
Guaranteed Revenue for 1998 shall be increased by $[*   * ] per day for 
each day prior to August 15, 1998 on which the Modifications are fully
operational."

     11.  Section 6.2(b) of the Agreement is hereby amended as follows:  (i) the
line

          "For each month after June 30, 1998 and on or before December 31, 1998
$[*     *] million"

shall be deleted in its entirety and replaced with the following lines:

          "For the month of July 1998                        $[*     *]
million";

          "For the month of August 1998                      $[*     *]
million";

          "For each month after August 31, 1998

               and on or before December 31, 1998            $[*     *]
million";
 
          "For each month after December 31, 1998

               and on or before December 31, 1999            $[*     *]
million"

and (ii) the following shall be inserted at the end of Section 6.2(b): "If the
Modifications are not fully operational for the production of [ *    *    *    *
] by August 15, 1998, the interim payments for Guaranteed Revenues set forth
above for the month of August 1998 or any month thereafter shall be reduced by
$[ *    *   ] per day for each day on or after August 15, 1998 falling within
that month on which the Modification is not fully operational, and 

                                       5
<PAGE>
 
                                              CONFIDENTIAL TREATMENT REQUESTED.
                                              OMITTED PORTIONS HAVE BEEN FILED
                                              SEPARATELY WITH THE COMMISSION.

if the Modifications are fully operational for the production of 
[*    *     *     *] prior to August 15, 1998, the interim payments for 
Guaranteed Revenues set forth above for the month of July and/or August 1998, 
as the case may be, shall be increased by $[ *   * ] per day for each day in 
that month prior to August 15, 1998 on which the Modification is fully 
operational."

     12.  Section 2.3(a) is hereby amended by deleting the date "December 31,
1997" from the third sentence and replacing it with the date "December 31,
1998."

     13.  Section 5.1(e) is hereby amended by deleting that subsection in its
entirety and replacing it with the following:

          "Certain [  *    *    *   ] Charges.  To the extent Supplier must
           ----------------------------------                              
     utilize the pilot plant for the production of [  *    *    *  ] in order to
     meet GWI's Binding Primary Commitment for Primary Products to be delivered
     in 1997 or 1998, the Conversion Charge for any [  *    *    *    ] required
     to be and actually manufactured in the [*      *     *     *     *     *
     *     *     *     *] shall be increased by $[*     *] per kilogram over the
     Conversion Charge as determined under Section 5.1(a); provided, however,
     that the obligations of GWI to make payments under this Section 5.1(e)
     shall be suspended during any period beginning on August 15, 1998 that the
     First and Second Modifications have not become fully operational for the
     production of [*    *    *   *    *    *] until the date on which the First
     and Second Modifications are fully operational. Payments due under the
     provisions of this Section 5.1(e) which are in excess of the Conversion
     Charge as determined under Section 5.1(a) for the period September 1, 1997
     through December 

                                       6
<PAGE>
 
                                              CONFIDENTIAL TREATMENT REQUESTED.
                                              OMITTED PORTIONS HAVE BEEN FILED
                                              SEPARATELY WITH THE COMMISSION.

     31, 1997, and all payments due under this Section for 1998 are in addition
     to the payment of Guaranteed Revenues specified in Section 6.1 hereof."

     14.  Schedule 2.4(b)(i), which is attached to the Agreement and
incorporated therein by reference, is hereby amended by deleting the pages of
the Schedule entitled "1998 [*    *    *    *]" and "1999 [*    *    *   *
*]" and substituting therefor the attached pages designated "Schedule 2.4(b)(i)
- - 2/nd/ Half 1998 [*    *    *   *] (Revised) - GW Profile Plant" and "Schedule
2.4(b)(i) - 1999 [*    *    *    *     *] (Revised) - GW Profile Plant", in the
form attached hereto.

     15.  Except as specifically modified or amended hereby, the Agreement shall
remain in full force and effect and, as modified or amended, is hereby ratified,
confirmed and approved.  No provision of this Amendment may be modified or
amended except expressly in a writing signed by both parties nor shall any terms
be waived except in a writing signed by the party charged therewith.  This
Amendment shall be governed in accordance with the laws of the State of North
Carolina.

                                       7
<PAGE>
 
     IN WITNESS WHEREOF, each of the parties have executed this Amendment No. 1
as of the date first written above.
                              GLAXO WELLCOME INC.


                                    /s/ Clifford Disbrow
                              By:   ______________________________
                                    Name:  Clifford Disbrow
                                    Title:


                              CATALYTICA PHARMACEUTICALS, INC.


                                    /s/ Gabriel Cipau
                              By:   ______________________________
                                    Name:  Gabriel Cipau
                                    Title: President


                              CATALYTICA, INC.
                              Executing this Amendment No. 1 for the purposes
                              set forth in Section 25.14 of the Agreement and as
                              required by Section 25.7 thereof


                                    /s/ Ricardo B. Levy
                              By:   _______________________________
                                    Name:  Ricardo B. Levy
                                    Title: President

                                       8

<PAGE>

                                                                    EXHIBIT 10.2
 
                                                                EXECUTION COPY



                    EFFECTIVENESS AGREEMENT dated as of June 4, 1998 (as the
               same may from time to time be amended, supplemented or otherwise
               modified, this "Effectiveness Agreement"), among CATALYTICA,
               INC., a Delaware corporation ("Catalytica"), CATALYTICA
               PHARMACEUTICALS, INC. (the "Borrower"), the lenders listed on
               Schedule I hereto as Departing Lenders (the "Departing Lenders")
               and Continuing Lenders (the "Continuing Lenders," and
               collectively with the Departing Lenders, the "Lenders"), and THE
               CHASE MANHATTAN BANK, as Administrative Agent, Documentation
               Agent, Issuing Bank and Collateral Agent, in each case under the
               Credit Agreement dated as of July 31, 1997, as amended as of
               January 6, 1998 (as in effect immediately prior to the
               effectiveness of the transactions contemplated by this Agreement,
               the "Original Credit Agreement"), among Catalytica, the Borrower,
                    -------------------------                                   
               the lenders referred to therein, the Administrative Agent, the
               Collateral Agent and Issuing Bank.


          WHEREAS, Catalytica and the Borrower have requested, and the Lenders,
the Issuing Bank, the Administrative Agent and the Collateral Agent have agreed,
upon the terms and subject to the conditions set forth herein, that the Original
Credit Agreement be amended and restated as provided herein effective upon
satisfaction of the conditions set forth in Section 7 below;

          NOW, THEREFORE, Catalytica, the Borrower, each of the Lenders, the
Issuing Bank, the Administrative Agent and the Collateral Agent hereby agree as
follows:

          SECTION 1.  Defined Terms.  Capitalized terms used but not defined
                      --------------                                        
herein shall have the meanings assigned to such terms in the form of amended and
restated Credit Agreement attached as Exhibit A hereto (the "Restated Credit
Agreement").

          SECTION 2.  Restatement Date.  (a)  The transactions provided for in
                      -----------------                                       
Sections 3, 4, 5 and 6 hereof shall be consummated at a closing (the "Closing")
to be held on the Restatement Date (as hereinafter defined) at the offices of
Cravath, Swaine & Moore, or at such other time and place as the parties shall
agree.

          (b)  The "Restatement Date" shall be specified by the Borrower, and
shall be a date not later than June 30, 1998, as of which all the conditions set
forth or referred to in Section 7 hereof shall have been satisfied.  The
Borrower shall give not less than one Business Day's written notice proposing a
date as the Restatement Date to the Administrative Agent, which shall send
copies of such notice to the Lenders.  This Effectiveness Agreement shall
terminate at 5:00 p.m., New York City time, on June 30, 1998, if the Restatement
Date shall not have occurred at or prior to such time.

          SECTION 3.  Amendment and Restatement of the Original Credit
                      ------------------------------------------------ 
Agreement. The Original Credit Agreement (including all Exhibits and Schedules
- ----------                                                                    
thereto) is hereby amended and restated, effective as of the Restatement Date
(subject to the satisfaction of the conditions set forth in Section 7 below), to
read in its entirety as set forth in Exhibit A hereto. As used in the Original
Credit Agreement, the terms "Agreement", "this Agreement", "herein",
"hereinafter", "hereto", "hereof" and words of similar import shall, unless the
<PAGE>
 
                                                                               2

context otherwise requires, mean the Original Credit Agreement as amended and
restated pursuant to this Effectiveness Agreement.  As used in the Loan
Documents, the term "Credit Agreement" shall, unless the context otherwise
requires, mean the Original Credit Agreement as amended and restated pursuant to
this Effectiveness Agreement.  On and after the Restatement Date, the rights and
obligations of the parties hereto other than the Departing Lenders shall be
governed by the Restated Credit Agreement and the documents related thereto;
                                                                            
provided that the rights and obligations of the parties to the Original Credit
- --------                                                                      
Agreement with respect to the period prior to the Restatement Date shall
continue to be governed by the provisions of the Original Credit Agreement and
the documents related thereto.

          SECTION 4.  Delivery of Notes.  On or prior to the Restatement Date,
                      ------------------                                      
each Departing Lender, if any, holding a promissory note evidencing Loans of any
Class shall deliver to the Administrative Agent, for delivery to and cancelation
by the Borrower as provided below, all such notes then held by such Departing
Lender (collectively, the "Notes").  Each Departing Lender holding a Note that
fails so to deliver any of its Notes hereby agrees to indemnify the Borrower for
any loss, cost or expense resulting from such failure.  Upon the effectiveness
of the Restated Credit Agreement, the Administrative Agent shall release and
deliver the Notes to the Borrower for cancelation.

          SECTION 5.  Fees and Expenses.  On the Restatement Date, on or before
                      ------------------                                       
the effectiveness of the Restated Credit Agreement, the Borrower shall pay to
the Administrative Agent (a) for its own account, all fees and other amounts
owed to it as of the Restatement Date, (b) for the account of each Lender (i)
the amendment fee due to such Lender on the Restatement Date, (ii) all unpaid
fees accrued to but excluding the Restatement Date for the account of such
Lender under Section 2.11 of the Credit Agreement, (iii) all unpaid interest
accrued to but excluding the Restatement Date in respect of the Loans of such
Lender outstanding under the Original Credit Agreement and (iv) any amount due
to such Lender under Section 2.15 of the Original Credit Agreement in connection
with any reduction of its outstanding Loans as a result of the transactions
contemplated by Section 6(b) below (deeming any such reduction of any such Loan
to be a prepayment of the subject Loan for purposes of such Section 2.15), (c)
for the account of the Issuing Bank, all unpaid fees accrued to but excluding
the Restatement Date for the account of the Issuing Bank under Section 2.11 of
the Credit Agreement and (d) for the account of each applicable payee, all
expenses due and payable under the Restated Credit Agreement on or before the
Restatement Date in connection with the Loan Documents to be delivered on the
Restatement Date or otherwise, including, without limitation, the reasonable
fees and expenses accrued and invoiced through the Restatement Date of Cravath,
Swaine & Moore.  The fees described in this Section 5 shall be payable in
immediately available funds.  Once paid, such fees shall not be refundable under
any circumstances.

          SECTION 6.  Assignments.  (a)  On the Restatement Date, upon the
                      ------------                                        
effectiveness of the Restated Credit Agreement and subject to the terms and
conditions set forth herein, each of the Departing Lenders shall be deemed to
have sold and assigned to certain of the Continuing Lenders, and each of such
Continuing Lenders shall be deemed to have purchased and assumed from the
Departing Lenders, (i) without any payment, such interests in the Commitments
under the Original Credit Agreement of the Departing Lenders on the Restatement
Date, (ii) at the principal amount thereof, such interests in the Loans of the
Departing Lenders outstanding on the Restatement Date and (iii) without any
payment, such interests in participations in Letters of Credit of the Departing
Lenders outstanding on 
<PAGE>
 
                                                                               3

the Restatement Date (the interests set forth in subsections (i), (ii) and
(iii) above to be referred to herein as the "Assigned Interest") as shall be
necessary in order that, after giving effect to all such sales and assignments
and purchases and assumptions (and the redesignation of Term Loans as
Revolving Loans as set forth in Section 2.01 of the Restated Credit
Agreement), the Assigned Interests will be held by the Continuing Lenders in
accordance with the amounts set forth on Schedule 2.01 to the Restated Credit
Agreement. Such sales and assignments and purchases and assumptions shall be
without recourse or representation, except that each Departing Lender shall be
deemed to have represented that it is the legal and beneficial owner of the
interests assigned by it free and clear of any adverse claim. The interest
rate applicable to any portion of any Eurodollar Loan assigned to any
Continuing Lender pursuant to this Section 6 on the Restatement Date shall be
increased until the termination of the Interest Period applicable thereto on
the Restatement Date by an amount equal to the difference, if positive, as
determined by the Administrative Agent (which determination shall be
conclusive absent manifest error), between the Adjusted LIBO Rate that would
apply to a Loan made on the Restatement Date for an interest period as close
as is available to the period extending from the Restatement Date to the last
day of such Interest Period and the Adjusted LIBO Rate initially used to
determine such interest rate.

          (b)  On the Restatement Date, upon the effectiveness of the Restated
Credit Agreement and subject to the terms and conditions set forth herein, (i)
each Continuing Lender purchasing and assuming the Assigned Interests pursuant
to paragraph (a) above shall pay the purchase price for the Assigned Interests
purchased by it pursuant to such paragraph (a) by wire transfer of immediately
available funds to the Administrative Agent not later than 12:00 Noon (New York
City time) and (ii) the Administrative Agent shall pay to each Departing Lender
selling and assigning the Assigned Interests pursuant to paragraph (a) above,
out of the amounts received by it pursuant to clause (i) of this paragraph (b),
the purchase price for the Assigned Interests assigned by it pursuant to such
paragraph (a) by wire transfer of immediately available funds to the account
designated by such Lender to the Administrative Agent not later than 5:00 p.m.
(New York City time); provided, however that the execution, delivery or
                      --------  -------                                
effectiveness of this Effectiveness Agreement shall not affect the Borrower's
obligations accrued in respect of any principal, interest, fees or other amounts
under the Original Credit Agreement or discharge or release the Lien or priority
of any pledge agreement or any other security therefor.  The Borrower agrees
that if any Lender shall default in the payment of any amount due from it under
this Section 6, the Borrower shall promptly pay the defaulted amount to the
Administrative Agent by wire transfer of immediately available funds, together
with interest on such amount at the Alternate Base Rate from the Restatement
Date to the date of payment.  Upon any such payment by the Borrower, (i) the
Borrower shall be subrogated to all rights of the assigning Lender against the
defaulting Lender and (ii) the Borrower shall have the right, at the defaulting
Lender's expense, upon notice to the defaulting Lender and to the Administrative
Agent, to require such defaulting Lender to transfer and assign without recourse
(in accordance with and subject to the restrictions contained in Section 9.04 of
the Restated Credit Agreement) all its interests, rights and obligations under
the Restated Credit Agreement to another financial institution which shall
assume such interests, rights and obligations; provided that (A) no such
                                               --------                 
assignment shall conflict with any law, rule or regulation or order of any
Governmental Authority and (B) the assignee shall pay to the defaulting
Lender, in immediately available funds on the date of such assignment, the
outstanding principal of and interest accrued to the date of payment on the
Loans made or deemed made by such defaulting Lender under the Restated Credit
Agreement, if any, and
<PAGE>
 
                                                                               4

all other amounts accrued for such defaulting Lender's account or owed to it
under the Restated Credit Agreement.

          (c)  Concurrently with the sales and assignments and purchases and
assumptions contemplated by paragraphs (a) and (b) of this Section, the
Departing Lenders shall cease to be parties to the Original Credit Agreement and
shall be released from all further obligations thereunder and shall have no
further rights to or interest in any of the Collateral; provided, however, that
                                                        --------  -------      
the Departing Lenders shall continue to be entitled to the benefits of all
expense reimbursement and indemnity provisions contained in the Original Credit
Agreement as in effect immediately prior to the Closing and shall continue to be
bound by Section 9.12 of the Original Credit Agreement as in effect at such
time.

          (d)  The Borrower hereby consents to the assignments and purchases
provided for in paragraphs (a) and (b) above and agrees that each Continuing
Lender shall have all the rights of a Lender under the Restated Credit Agreement
with respect to the interests purchased by it pursuant to such paragraphs.

          (e)  In the event the Borrower shall specify a date as the Restatement
Date and the Restatement Date shall not occur on such date, the Borrower shall
indemnify each Lender for any loss or expense incurred by such Lender as a
result of the transactions to have been consummated by such Lender on such
proposed Restatement Date, in each case determined as set forth in Section 2.15
of the Restated Credit Agreement in respect of any failure to borrow or prepay
any Loan (it being understood and agreed that the nonoccurrence of the sales and
assignments and purchases and assumptions contemplated by paragraphs (a) and (b)
of this Section shall be treated for purposes of such Section 2.15 as the
failure by the Borrower to repay the Loans of the Departing Lenders and to
borrow from the Continuing Lenders).

          SECTION 7.  Conditions.  The consummation of the transactions set
                      -----------                                          
forth in Sections 3, 4, 5 and 6 of this Effectiveness Agreement shall be subject
to the satisfaction of the following conditions precedent:

          (a)  All legal matters incident to this Effectiveness Agreement, the
     Restated Credit Agreement, the borrowings and extensions of credit
     thereunder and the other Loan Documents shall be reasonably satisfactory to
     the Lenders, to the Issuing Bank and to Cravath, Swaine & Moore, counsel
     for the Administrative Agent.

          (b)  The Administrative Agent shall have received a favorable written
     opinion (addressed to the Administrative Agent and the Lenders and dated
     the Restatement Date) of Wilson, Sonsini, Goodrich and Rosati, counsel for
     Catalytica and the Borrower, substantially in the form of Exhibit B to the
     Restated Credit Agreement and covering such matters relating to the Loan
     Parties, the Loan Documents or the Transactions as the Required Lenders
     shall reasonably request.  The Borrower hereby requests such counsel to
     deliver such an opinion.

          (c)  The Administrative Agent shall have received such documents and
     certificates as the Administrative Agent or its counsel may reasonably
     request relating to the organization, existence and good standing of each
     Loan Party, authorization of the transactions contemplated by the Restated
     Credit Agreement and any other legal matters relating to the Loan Parties,
     the Loan Documents or the 
<PAGE>
 
                                                                               5

     transactions contemplated by the Restated Credit Agreement, all in form
     and substance satisfactory to the Administrative Agent and its counsel.

          (d) (i) The representations and warranties of each Loan Party set
     forth in the Loan Documents are true and correct on and as of the
     Restatement Date except to the extent that such representations and
     warranties expressly relate to an earlier date, in which case such
     representations and warranties shall, to such extent, be true and correct
     as of such earlier date and (ii) at the time of and immediately after
     giving effect to the transactions contemplated by the Restated Credit
     Agreement, and the execution and delivery of the Loan Documents to be
     delivered on the Restatement Date, no Default has occurred and is
     continuing, and the Administrative Agent shall have received a certificate,
     dated the Restatement  Date and signed by the President, a Vice President
     or a Financial Officer of the Borrower, to the effect of clauses (i) and
     (ii) of this sentence.

          (e)  The Administrative Agent shall have received all fees and other
     amounts due and payable on or prior to the Restatement Date, including, to
     the extent invoiced, reimbursement or payment of all out-of-pocket expenses
     required to be reimbursed or paid by any Loan Party hereunder or under any
     other Loan Document.

          (f)  The Administrative Agent shall have received counterparts of the
     Reaffirmation Agreement signed on behalf of Catalytica, the Borrower and
     each Subsidiary Loan Party.

          (g)  The Administrative Agent shall have received all documents and
     instruments, including Uniform Commercial Code financing statements or
     amendments thereto, required by law or reasonably requested by the
     Administrative Agent to be filed, registered or recorded to create or
     perfect the Liens intended to be created under the Security Agreement.

          (h)  The Administrative Agent shall have received (i) counterparts of
     the Amendment of Deed of Trust with respect to the Mortgaged Property
     signed on behalf of the record owner of such Mortgaged Property and (ii) a
     policy or policies of title insurance issued by a nationally recognized
     title insurance company, insuring the Lien of the Deed of Trust granted by
     the Borrower in connection with the Original Credit Agreement, as amended
     by the Amendment of Deed of Trust, as a valid Lien on the Mortgaged
     Property described therein, free of any other Liens except as permitted by
     Section 6.02 of the Restated Credit Agreement, in form and substance
     reasonably acceptable to the Administrative Agent, together with such
     endorsements, coinsurance and reinsurance as the Administrative Agent or
     the Required Lenders may reasonably request.

          (i)  All material consents and approvals required to be obtained from
     and all material registrations and filings with any Governmental Authority
     or other Person in connection with the transactions contemplated by this
     Effectiveness Agreement or the Restated Credit Agreement shall have been
     obtained, all applicable waiting periods and appeal periods shall have
     expired, in each case without the imposition of any materially burdensome
     conditions, and there shall be no action by any Governmental Authority,
     actual or threatened, that has a reasonable likelihood of restraining,
     preventing or imposing materially burdensome conditions on the 
<PAGE>
 
                                                                               6

     transactions contemplated by this Effectiveness Agreement or the Restated
     Credit Agreement.

          (j)  There shall be no litigation or administrative proceeding that
     would reasonably be expected to have a Material Adverse Effect.

          (k)  The Administrative Agent shall have received financial
     projections for Catalytica, the Borrower and the Subsidiaries, as of the
     Restatement Date, certified in writing by a Financial Officer of
     Catalytica.  Such projections shall cover the five-fiscal-year period
     beginning on the Restatement Date and be in form and substance reasonably
     satisfactory to the Administrative Agent.

          SECTION 8.  Effectiveness; Counterparts.  This Effectiveness Agreement
                      ----------------------------                              
shall become effective when copies hereof which, when taken together, bear the
signatures of each of the parties hereto shall have been received by the
Administrative Agent.  This Effectiveness Agreement may not be amended nor may
any provision hereof be waived except pursuant to a writing signed by
Catalytica, the Borrower, the Administrative Agent, the Collateral Agent, the
Issuing Bank and the Lenders.  This Effectiveness Agreement may be executed in
two or more counterparts, each of which shall constitute an original but all of
which when taken together shall constitute but one contract.

          SECTION 9.  Notices.  All notices hereunder shall be given in
                      --------                                         
accordance with the provisions of Section 9.01 of the Restated Credit Agreement.

          SECTION 10.  APPLICABLE LAW; WAIVER OF JURY TRIAL.  (A)  THIS
                       -------------------------------------           
EFFECTIVENESS AGREEMENT SHALL BE CONSTRUED IN ACCORDANCE WITH AND GOVERNED BY
THE LAWS OF THE STATE OF NEW YORK.

          (B)  EACH PARTY HERETO HEREBY AGREES AS SET FORTH IN SECTION 9.10 OF
THE RESTATED CREDIT AGREEMENT AS IF SUCH SECTION WERE SET FORTH IN FULL HEREIN.

          SECTION 11.  Expenses; Indemnity.  The Borrower hereby agrees as set
                       --------------------                                   
forth in Section 9.03 of the Restated Credit Agreement as if such Section were
set forth in full herein.

          SECTION 12. Representations and Warranties. The Borrower hereby makes
                      -------------------------------                          
to each of the Administrative Agent, the Collateral Agent, the Additional
Lenders and the Continuing Lenders, on the date hereof and on the Restatement
Date, each of the representations and warranties contained in Article III of the
Restated Credit Agreement, and each of such representations and warranties is
hereby incorporated by reference herein.
 
          SECTION 13.  Survival.  Without limiting the provisions of Section 14,
                       ---------                                                
the representations and warranties in Section 12 and the provisions of Section 5
shall survive and remain operative and in full force and effect notwithstanding
the consummation of the transactions to be consummated on the Restatement Date
and the effectiveness or termination of the Restated Credit Agreement.

          SECTION 14.  Expenses.  The Borrower agrees to pay the reasonable
                       ---------                                           
fees, disbursements and other charges of counsel to the Administrative Agent and
the Collateral 
<PAGE>
 
                                                                               7

Agent, incurred in connection with the preparation of this Effectiveness
Agreement, the Restated Credit Agreement and the other documents contemplated
hereby or thereby (whether or not the transactions hereby or thereby
contemplated shall be consummated). The provisions of this Section 14 shall
survive and remain operative and in full force and effect regardless of
whether or not the transactions contemplated hereby are consummated.
<PAGE>
 
                                                                               8

          IN WITNESS WHEREOF, the parties hereto have caused this Effectiveness
Agreement to be duly executed by their duly authorized officers, all as of the
date and year first above written.


                                            CATALYTICA, INC.,

                                               by
                                                 /s/ LAWRENCE W. BRISCOE
                                                 --------------------------
                                                 Name:
                                                 Title: Chief Financial Officer
                             


                                            CATALYTICA PHARMACEUTICALS, INC.,

                                               by
                                                 /s/ LAWRENCE W. BRISCOE
                                                 --------------------------
                                                 Name: 
                                                 Title: Chief Financial Officer


                                            THE CHASE MANHATTAN BANK, 
                                            individually and as Administrative 
                                            Agent, Collateral, Agent and 
                                            Issuing Bank,

                                               by
                                                 /s/  JOAN F. GARVIN
                                                 --------------------------
                                                 Name:
                                                 Title: Managing Director


                                            BANK OF TOKYO-MITSUBISHI TRUST
                                            COMPANY,

                                               by
                                                 /s/ NICHOLAS J. CAMPBELL
                                                 --------------------------
                                                 Name:
                                                 Title: Vice President
<PAGE>
 
                                                                               9

                                            BANQUE PARIBAS,

                                               by
                                                 /s/ DON L. UNRUH
                                                 --------------------------
                                                 Name:
                                                 Title: Assistant Vice President

                                               by
                                                 /s/ CLARE BAILHE
                                                 --------------------------
                                                 Name:
                                                 Title:  Director


                                            COMERICA BANK,

                                               by
                                                 /s/ EMMANUEL M. SKEVOFILAX
                                                 --------------------------
                                                 Name:
                                                 Title: Assistant Vice President


                                            COOPERATIVE CENTRALE RAIFFEISEN-
                                            BOERENLEENBANK B.A., "RABOBANK 
                                            NEDERLAND", NEW YORK BRANCH,

                                               by
                                                 /s/ DANA W. HEMENWAY
                                                 --------------------------
                                                 Name:
                                                 Title: Vice President

                                               by
                                                 /s/ W. PIETER C. KODDE
                                                 --------------------------
                                                 Name:
                                                 Title: Vice President


                                            DRESDNER BANK AG, New York Branch 
                                            and Grand Cayman Branch,

                                               by
                                                 /s/ BEVERLY G. CASON
                                                 -------------------------
                                                 Name:
                                                 Title: Vice President
 
                                               by
                                                 /s/ BRIGITTE SACIN
                                                 -------------------------
                                                 Name:
                                                 Title: Assistant Treasurer
<PAGE>
 
                                                                              10

                                            FIRST UNION NATIONAL BANK,

                                               by
                                                 /s/ MARK B. FELKER
                                                 -------------------------
                                                 Name:
                                                 Title: Senior Vice President


                                            FLEET NATIONAL BANK,

                                               by
                                                 /s/ DOROTHY W. BAMBACH
                                                 -------------------------
                                                 Name:
                                                 Title: Senior Vice President


                                            NATEXIS BANQUE (previously known 
                                            as Banque Francaise Du Commerce 
                                            Exterieur),

                                               by
                                                 /s/ LAIN A. WHYTE
                                                 -------------------------
                                                 Name:
                                                 Title: Vice President

                                               by
                                                 /s/ DANIEL TOUFFU
                                                 -------------------------
                                                 Name:
                                                 Title: First VP and Regional 
                                                        Manager


                                            THE BANK OF NOVA SCOTIA,

                                               by
                                                 /s/ JOHN QUICK
                                                 -------------------------
                                                 Name:
                                                 Title: Senior Relationship 
                                                        Manager


                                            THE INDUSTRIAL BANK OF JAPAN, 
                                            LIMITED,

                                               by
                                                 /s/ YOSHIO MINATO
                                                 -------------------------
                                                 Name:
                                                 Title: Deputy General Manager
<PAGE>
 
                                                                              11

                                            THE MITSUBISHI TRUST AND BANKING 
                                            CORPORATION,

                                               by
                                                 /s/ BEATRICE E. KOSSODO
                                                 -------------------------
                                                 Name:
                                                 Title: Senior Vice President


                                            THE ROYAL BANK OF SCOTLAND PLC,

                                               by
                                                 /s/ DEREK BONNAR
                                                 -------------------------
                                                 Name:
                                                 Title: Vice President


                                            UNION BANK OF CALIFORNIA, N.A.,

                                               by
                                                 /s/ WANDA HEADRICK
                                                 -------------------------
                                                 Name:
                                                 Title: Vice President


                                            WACHOVIA BANK, N.A.,
 
                                               by
                                                 /s/ DAVID K. ALEXANDER
                                                 -------------------------
                                                 Name:
                                                 Title: Senior Vice President
<PAGE>
 
                                                                      SCHEDULE I
Departing Lenders
- -----------------


1.      BANQUE PARIBAS
2.      COMERICA BANK


Continuing Lenders
- ------------------


1.      BANK OF TOKYO-MITSUBISHI TRUST COMPANY
2.      COOPERATIVE CENTRALE RAIFFEISEN-BOERENLEENBANK B.A.,
        "RABOBANK NEDERLAND", New York Branch
3.      DRESDNER BANK AG, New York Branch and Grand Cayman Branch,
4.      FIRST UNION NATIONAL BANK
5.      FLEET NATIONAL BANK
6.      NATEXIS BANQUE (previously known as Banque Francaise Du Commerce
        Exterieur)
7.      THE BANK OF NOVA SCOTIA
8.      THE INDUSTRIAL BANK OF JAPAN, LIMITED
9.      THE MITSUBISHI TRUST AND BANKING CORPORATION
10.     THE ROYAL BANK OF SCOTLAND PLC
11.     UNION BANK OF CALIFORNIA, N.A.
12.     WACHOVIA BANK, N.A.
<PAGE>
 
                                        Exhibit A to the Effectiveness Agreement
 
 
                               CATALYTICA, INC.
 
                       CATALYTICA PHARMACEUTICALS, INC.
 
 
 
                                 $175,000,000
 
                               Credit Agreement
 
                          Dated as of July 31, 1997,
                     as Amended as of January 6, 1998, and
                    Amended and Restated as of June 4, 1998
 
 
 
 
                           The Lenders Party Hereto
 
 
 
 
 
                           The Chase Manhattan Bank
                            as Administrative Agent
                          and as Documentation Agent
 
                             Chase Securities Inc.
                                  as Arranger
 
________________________________________________________________________________

         CHASE
________________________________________________________________________________
<PAGE>
 
                               TABLE OF CONTENTS


                                                                            Page
                                                                            ----
<TABLE>
<CAPTION>
                                   ARTICLE I

                                  Definitions
                                  -----------

<S>             <C>                                                        <C>
SECTION 1.01.   Defined Terms..............................................   1
SECTION 1.02.   Classification of Loans and Borrowings.....................  23
SECTION 1.03.   Terms Generally............................................  23
SECTION 1.04.   Accounting Terms; GAAP.....................................  24


                                  ARTICLE II

                                  The Credits
                                  -----------

SECTION 2.01.   Redesignation of $25,000,000 of Loans; Commitments.........  24
SECTION 2.02.   Loans and Borrowings.......................................  25
SECTION 2.03.   Requests for Borrowings....................................  25
SECTION 2.04.   Letters of Credit..........................................  26
SECTION 2.05.   Funding of Borrowings......................................  30
SECTION 2.06.   Interest Elections.........................................  30
SECTION 2.07.   Termination and Reduction of Commitments...................  32
SECTION 2.08.   Repayment of Loans; Evidence of Debt.......................  32
SECTION 2.09.   Amortization of Term Loans.................................  33
SECTION 2.10.   Prepayment of Loans........................................  34
SECTION 2.11.   Fees.......................................................  35
SECTION 2.12.   Interest...................................................  36
SECTION 2.13.   Alternate Rate of Interest.................................  36
SECTION 2.14.   Increased Costs............................................  37
SECTION 2.15.   Break Funding Payments.....................................  38
SECTION 2.16.   Taxes......................................................  38
SECTION 2.17.   Payments Generally; Pro Rata Treatment; Sharing of Setoffs.  40
SECTION 2.18.   Mitigation Obligations; Replacement of Lenders.............  41


                                  ARTICLE III

                        Representations and Warranties
                        ------------------------------

SECTION 3.01.   Organization; Powers.......................................  42
SECTION 3.02.   Authorization; Enforceability..............................  42
SECTION 3.03.   Governmental Approvals; No Conflicts.......................  43
SECTION 3.04.   Financial Condition; No Material Adverse Change............  43
SECTION 3.05.   Properties.................................................  44
SECTION 3.06.   Litigation and Environmental Matters.......................  44
SECTION 3.07.   Compliance with Laws and Agreements........................  45
</TABLE>
<PAGE>
 
                                                                               2

<TABLE>
<S>             <C>                                                        <C>
SECTION 3.08.   Investment and Holding Company Status......................  45
SECTION 3.09.   Taxes......................................................  45
SECTION 3.10.   ERISA......................................................  45
SECTION 3.11.   Disclosure.................................................  45
SECTION 3.12.   Subsidiaries...............................................  46
SECTION 3.13.   Insurance..................................................  46
SECTION 3.14.   Labor Matters..............................................  46
SECTION 3.15.   Solvency...................................................  46
SECTION 3.16.   Security Documents.........................................  47
SECTION 3.17.   Federal Reserve Regulations................................  48
SECTION 3.18.   Year 2000..................................................  48


                                  ARTICLE IV

                                  Conditions
                                  ----------

SECTION 4.01.   [Intentionally Omitted]....................................  48
SECTION 4.02.   Each Credit Event..........................................  49


                                   ARTICLE V

                             Affirmative Covenants
                             ---------------------

SECTION 5.01.   Financial Statements and Other Information.................  49
SECTION 5.02.   Notices of Material Events.................................  51
SECTION 5.03.   Information Regarding Collateral...........................  52
SECTION 5.04.   Existence; Conduct of Business.............................  52
SECTION 5.05.   Payment of Obligations.....................................  53
SECTION 5.06.   Maintenance of Properties..................................  53
SECTION 5.07.   Insurance..................................................  53
SECTION 5.08.   Casualty and Condemnation..................................  54
SECTION 5.09.   Books and Records; Inspection and Audit Rights.............  54
SECTION 5.10.   Compliance with Laws.......................................  55
SECTION 5.11.   Use of Proceeds and Letters of Credit......................  55
SECTION 5.12.   Additional Restricted Subsidiaries.........................  55
SECTION 5.13.   Further Assurances.........................................  55


                                  ARTICLE VI

                              Negative Covenants
                              ------------------
SECTION 6.01.   Indebtedness; Certain Equity Securities....................  56
SECTION 6.02.   Liens......................................................  57
SECTION 6.03.   Fundamental Changes........................................  58
SECTION 6.04.   Investments, Loans, Advances, Guarantees and Acquisitions..  59
SECTION 6.05.   Asset Sales................................................  60
</TABLE>
<PAGE>
 
                                                                               3

<TABLE>
<S>             <C>                                                        <C>
SECTION 6.06.   Sale and Lease-Back Transactions...........................  61
SECTION 6.07.   Hedging Agreements.........................................  62
SECTION 6.08.   Restricted Payments........................................  62
SECTION 6.09.   Transactions with Affiliates...............................  62
SECTION 6.10.   Restrictive Agreements.....................................  62
SECTION 6.11.   Sterile Facility Pay-Out...................................  63
SECTION 6.12.   Amendment of Material Documents............................  63
SECTION 6.13.   Capital Expenditures.......................................  63
SECTION 6.14.   Leverage Ratio.............................................  64
SECTION 6.15.   Consolidated Interest Expense Coverage Ratio...............  64



                                  ARTICLE VII

                               Events of Default...........................  64
                               -----------------

                                 ARTICLE VIII

                           The Administrative Agent........................  67
                           ------------------------


                                  ARTICLE IX

                                 Miscellaneous
                                 -------------

SECTION 9.01.   Notices....................................................  69
SECTION 9.02.   Waivers; Amendments........................................  70
SECTION 9.03.   Expenses; Indemnity; Damage Waiver.........................  71
SECTION 9.04.   Successors and Assigns.....................................  72
SECTION 9.05.   Survival...................................................  75
SECTION 9.06.   Counterparts; Integration; Effectiveness...................  75
SECTION 9.07.   Severability...............................................  75
SECTION 9.08.   Right of Setoff............................................  75
SECTION 9.09.   Governing Law; Jurisdiction; Consent to Service of Process.  76
SECTION 9.10.   Waiver of Jury Trial.......................................  76
SECTION 9.11.   Headings...................................................  77
SECTION 9.12.   Confidentiality............................................  77
SECTION 9.13.   Interest Rate Limitation...................................  77
</TABLE>
<PAGE>
 
                                                                               4


SCHEDULES:
- ---------
 
Schedule 1.01(a)    -   Mortgaged Properties
Schedule 2.01       -   Commitments and Loans Outstanding
Schedule 3.05       -   Real Property
Schedule 3.06       -   Disclosed Matters
Schedule 3.12       -   Subsidiaries
Schedule 3.13       -   Insurance
Schedule 3.16(d)    -   Mortgage Filing Offices
Schedule 6.01       -   Existing Indebtedness
Schedule 6.02       -   Existing Liens
Schedule 6.04       -   Existing Investments
Schedule 6.10       -   Existing Restrictions
 
EXHIBITS:
- --------
 
Exhibit A           -   Form of Assignment and Acceptance
Exhibit A-1         -   Form of Administrative Questionnaire
Exhibit B           -   Form of Opinion of Borrower's Counsel
Exhibit C           -   Form of Opinion Local Counsel
Exhibit D           -   Parent Guarantee Agreement
Exhibit E           -   Guarantee Agreement
Exhibit F           -   Indemnity, Subrogation and Contribution Agreement
Exhibit G           -   Pledge Agreement
Exhibit H           -   Security Agreement
Exhibit I           -   Form of Mortgage
Exhibit J           -   Form of Amendment of Deed of Trust
Exhibit K           -   Form of Reaffirmation Agreement
<PAGE>
 
                        CREDIT AGREEMENT dated as of July 31, 1997, as amended
                as of January 6, 1998, and amended and restated as of June 4,
                1998, among CATALYTICA, INC., a Delaware corporation, CATALYTICA
                PHARMACEUTICALS, INC., a Delaware corporation, as Borrower, the
                LENDERS party hereto and THE CHASE MANHATTAN BANK, as
                Administrative Agent, as Collateral Agent, as Documentation
                Agent and as Issuing Bank.


          The Borrower (such term and each other capitalized term used but not
defined herein having the meaning assigned to it in Article I), Catalytica, the
Administrative Agent, the Collateral Agent, the Documentation Agent, the Issuing
Bank and the Lenders are parties to a Credit Agreement dated as of July 31,
1997, as amended as of January 6, 1998 (as in effect immediately prior to the
effectiveness of the transactions contemplated by this Agreement, the "Original
                                                                       --------
Credit Agreement"), pursuant to which such Lenders (a) committed to make
- ----------------                                                        
Revolving Loans to the Borrower at any time and from time to time prior to the
Maturity Date, in an aggregate principal amount at any time outstanding not in
excess of $75,000,000 less the LC Exposure at such time and (b) made Term Loans
to the Borrower in an aggregate principal amount of $125,000,000, $25,000,000 of
which was subsequently prepaid in accordance with the prepayment procedures set
forth in the Original Credit Agreement.

          The Borrower has requested that the Original Credit Agreement be
amended in order (a) to redesignate $25,000,000 of the Term Loans outstanding as
of the Restatement Date to be an equal amount of Revolving Loans and in
connection therewith increase the Revolving Commitments by an aggregate amount
of $25,000,000 and (b) to effect certain other changes.

          The Lenders are willing to amend the Original Credit Agreement for
such purposes and to restate the Original Credit Agreement as so amended in the
form hereof, subject to the terms and conditions hereinafter set forth.

          Accordingly, in consideration of the foregoing and the mutual
covenants set forth herein, the parties hereto agree as follows:


                                   ARTICLE I

                                  Definitions
                                  -----------

          SECTION 1.01.  Defined Terms.  As used in this Agreement, the
                         --------------                                
following terms have the meanings specified below:

          "ABR", when used in reference to any Loan or Borrowing, refers to
           ---                                                             
whether such Loan, or the Loans comprising such Borrowing, are bearing interest
at a rate determined by reference to the Alternate Base Rate.

          "Acquired EBITDA" means, with respect to any Acquired Entity or
           ---------------                                               
Business or any Sold Entity or Business for any period, the sum of the amounts
for such 
<PAGE>
 
                                                                               2


period of net income or loss of such Acquired Entity or Business or Sold Entity
or Business determined on a consolidated basis in accordance with GAAP, plus,
without duplication and to the extent deducted from revenues in determining such
consolidated net income or loss, the sum of (a) the aggregate amount of interest
expense, both expensed and capitalized (including the interest component in
respect of Capital Lease Obligations but excluding capitalized interest included
as an addition to property, plant and equipment or other capital expenditure for
tangible assets in accordance with GAAP), accrued or paid by such Acquired
Entity or Business or Sold Entity or Business and its subsidiaries during such
period, in each case as determined on a consolidated basis in accordance with
GAAP, (b) the aggregate amount of letter of credit fees paid during such period,
(c) the aggregate amount of income tax expense for such period, (d) all amounts
attributable to depreciation, amortization and other similar non-cash charges
for such period and (e) all extraordinary charges during such period, and minus,
without duplication and to the extent added to revenues in determining such
consolidated net income or loss for such period, all extraordinary gains during
such period, with all of the foregoing determined on a consolidated basis with
respect to such Acquired Entity or Business or Sold Entity or Business in
accordance with GAAP.

          "Acquired Entity or Business" has the meaning assigned to such term in
           ---------------------------                                          
the definition of Adjusted Consolidated EBITDA.

          "Acquired Facilities" means (a) certain real property consisting of 17
           -------------------                                                  
separate parcels of land consisting of approximately 582 acres, located in
Greenville, North Carolina, including (i) all rights, privileges and easements
appurtenant to such property and (ii) all the improvements and fixtures located
on such property, (b) certain machinery, equipment, furniture, fixtures,
transportation, maintenance and distribution equipment, waste treatment
facilities, computers, analytical equipment, instruments, communication
equipment, control systems, spare parts, supplies, materials and other items of
tangible personal property, (c) certain motor vehicles and (d) certain
intellectual and other property, in each case as specified in the Asset Purchase
Agreement.

          "Acquisition" means the acquisition, pursuant to the Asset Purchase
           -----------                                                       
Agreement, by the Borrower from GWI of the Acquired Facilities for consideration
consisting of (a) $246,600,000 in cash (subject to adjustments as provided in
the Asset Purchase Agreement) payable by the Borrower to GWI, (b) the issuance
to GWI on the Effective Date of (i) 250,000 shares of the Junior Preferred Stock
and (ii) the Warrants and (c) the payment by the Borrower to GWI from time to
time after the Effective Date of the Sterile Facility Pay-Out.

          "Acquisition Documents" means the Asset Purchase Agreement, the Junior
           ---------------------                                                
Preferred Purchase Agreement, the Warrant Purchase Agreement, the Investment
Agreement, the Share Exchange Agreement, the Supply Agreement and any other
document entered into in connection with the Acquisition to which the Borrower,
Catalytica, MSCP or GWI is a party.

          "Adjusted Consolidated EBITDA" means, for any period, Consolidated
           ----------------------------                                     
EBITDA for such period, calculated by (a) including in the determination thereof
the Acquired EBITDA of any Person, property, business or asset in Catalytica's,
the Borrower's or any Restricted Subsidiary's line of business acquired pursuant
to a transaction permitted under Section 6.04 and not subsequently sold,
transferred or 
<PAGE>
 
                                                                               3

otherwise disposed of (but not including the Acquired EBITDA of any related
Person, property, business or assets to the extent not so acquired) by
Catalytica, the Borrower or any of the Restricted Subsidiaries during such
period (each such Person, property, business or asset in Catalytica's, the
Borrower's or any Restricted Subsidiary's line of business acquired and not
subsequently so disposed of, an "Acquired Entity or Business"), based on the
actual Acquired EBITDA of such Acquired Entity or Business for such period
(including the portion thereof occurring prior to such acquisition) and (b)
excluding in the determination thereof the Acquired EBITDA of any Person,
property, business or asset sold, transferred or otherwise disposed of by
Catalytica, the Borrower or any of the Restricted Subsidiaries during such
period (each such Person, property, business or asset so sold or disposed of, a
"Sold Entity or Business") based on the actual Acquired EBITDA of such Sold
Entity or Business for such period (including the portion thereof occurring
prior to such sale, transfer or disposition).

          "Adjusted LIBO Rate" means, with respect to any Eurodollar Borrowing
           ------------------                                                 
for any Interest Period, an interest rate per annum (rounded upwards, if
necessary, to the next 1/16 of 1%) equal to (a) the LIBO Rate for such Interest
Period multiplied by (b) the Statutory Reserve Rate.

          "Administrative Agent" means The Chase Manhattan Bank, in its capacity
           --------------------                                                 
as administrative agent for the Lenders hereunder.

          "Administrative Questionnaire" means an Administrative Questionnaire
           ----------------------------                                       
in a form supplied by the Administrative Agent.

          "Advanced Sensor" means Advanced Sensor Devices, Inc., a California
           ---------------                                                   
corporation.

          "Advanced Technologies" means Catalytica Advanced Technologies, Inc.,
           ---------------------                                               
a Delaware corporation.

          "Advisory Compensation" means the issuance by Catalytica of 150,000
           ---------------------                                             
shares of common stock of Catalytica to Lehman Brothers Inc. for services
rendered in connection with the Acquisition.

          "Affiliate" means, with respect to a specified Person, another Person
           ---------                                                           
that directly, or indirectly through one or more intermediaries, Controls or is
Controlled by or is under common Control with the Person specified.

          "Alternate Base Rate" means, for any day, a rate per annum equal to
           -------------------                                               
the greatest of (a) the Prime Rate in effect on such day, (b) the Base CD Rate
in effect on such day plus 1% and (c) the Federal Funds Effective Rate in effect
on such day plus 1/2 of 1%.  Any change in the Alternate Base Rate due to a
change in the Prime Rate, the Base CD Rate or the Federal Funds Effective Rate
shall be effective from and including the effective date of such change in the
Prime Rate, the Base CD Rate or the Federal Funds Effective Rate, respectively.

          "Amendment of Deed of Trust" means the Amendment of Deed of Trust,
           --------------------------                                       
substantially in the form of Exhibit J, by and between the Collateral Agent and
the Borrower.
<PAGE>
 
                                                                               4

          "Applicable Percentage" means, with respect to any Revolving Lender,
           ---------------------                                              
the percentage of the total Revolving Commitments represented by such Lender's
Revolving Commitment.  If the Revolving Commitments have terminated or expired,
the Applicable Percentages shall be determined based upon the Revolving
Commitments most recently in effect, giving effect to any assignments made in
accordance with Section 9.04.

          "Applicable Rate" means, for any day with respect to any ABR Loan or
           ---------------                                                    
Eurodollar Loan, or with respect to the commitment fees payable hereunder, as
the case may be, the applicable rate per annum set forth below under the caption
"ABR Spread", "Eurodollar Spread" or "Commitment Fee Rate", as the case may be,
based upon the Leverage Ratio as of the most recent determination date; provided
                                                                        --------
that (i) until the third day after the delivery to the Administrative Agent,
pursuant to Section 5.01, of Catalytica's consolidated financial statements for
the fiscal quarter ending September 30, 1998, the "Applicable Rate" shall be the
applicable rate per annum set forth below in Category 3:

<TABLE>
<CAPTION>
 
                                                    ABR          Eurodollar        Commitment Fee
                                                  -------        -----------       ---------------
        Leverage Ratio:                           Spread           Spread               Rate
        ---------------                           -------        -----------       ---------------
<S>                                               <C>            <C>               <C>
                                                                             
        Category 1                                                                   
        ----------                                           
Equal to or greater than 3.50 to 1.00                .50%              1.50%                 .375%                         
                                                                             
        Category 2                                                                   
        ----------                                                                   
Less than 3.50 to 1.00 but equal to or greater       
 than 3.00 to 1.00                                   .25%              1.25%                 .375%                         
                                                                             
        Category 3                                                                   
        ----------                                                                   
Less than 3.00 to 1.00 but equal to or greater      
 than 2.50 to 1.00                                  0.00%              1.00%                  .25%                          
                                                                             
        Category 4                                                                   
        ----------                                          
Less than 2.50 to 1.00                              0.00%               .75%                  .25% 

</TABLE>


          For purposes of the foregoing, (a) the Leverage Ratio shall be
determined as at the last day of each fiscal quarter of Catalytica's fiscal year
based upon Catalytica's consolidated financial statements delivered pursuant to
Section 5.01(a) or (b) and (b) each change in the Applicable Rate resulting from
a change in the Leverage Ratio shall be effective during the period commencing
on and including the third day (such day, the "Applicable Rate Determination
Date") after the date of delivery to the Administrative Agent of such
consolidated financial statements indicating such change and ending on the date
immediately preceding the effective date of the next such change; provided that
                                                                  --------     
the Leverage Ratio shall be deemed to be in Category 1 (i) at any time that an
Event of Default (other than an Event of Default described in paragraph (e) of
Article VII) has occurred and is continuing or (ii) if Catalytica fails to
deliver the consolidated financial statements required to be delivered by it
pursuant to Section 5.01(a) or (b), during the period from the expiration of the
time for delivery thereof until such consolidated financial statements are
delivered.

          "Assessment Rate" means, for any day, the annual assessment rate in
           ---------------                                                   
effect on such day that is payable by a member of the Bank Insurance Fund
classified as "well-capitalized" and within supervisory subgroup "B" (or a
comparable successor risk classification) within the meaning of 12 C.F.R. Part
327 (or any successor provision) to the Federal Deposit Insurance Corporation
for insurance by such Corporation of time deposits made in dollars at the
offices of such member in the United States; provided that if, as a result of
                                             --------                        
any change in any law, rule or regulation, it is no longer possible to 
<PAGE>
 
                                                                               5

determine the Assessment Rate as aforesaid, then the Assessment Rate shall be
such annual rate as shall be determined by the Administrative Agent to be
representative of the cost of such insurance to the Lenders.

          "Asset Purchase Agreement" means the Asset Purchase Agreement dated as
           ------------------------                                             
of June 25, 1997, among GWI, the Borrower and Catalytica.

          "Assignment and Acceptance" means an assignment and acceptance entered
           -------------------------                                            
into by a Lender and an assignee (with the consent of any party whose consent is
required by Section 9.04), and accepted by the Administrative Agent, in the form
of Exhibit A or any other form approved by the Administrative Agent.

          "Base CD Rate" means the sum of (a) the Three-Month Secondary CD Rate
           ------------                                                        
multiplied by the Statutory Reserve Rate plus (b) the Assessment Rate.

          "Board" means the Board of Governors of the Federal Reserve System of
           -----                                                               
the United States of America.

          "Borrower" means Catalytica Pharmaceuticals, Inc., a Delaware
           --------                                                    
corporation.

          "Borrowing" means Loans of the same Class and Type, made, converted or
           ---------                                                            
continued on the same date and, in the case of Eurodollar Loans, as to which a
single Interest Period is in effect.

          "Borrowing Request" means a request by the Borrower for a Borrowing or
           -----------------                                                    
Borrowings in accordance with Section 2.03.

          "Business Day" means any day that is not a Saturday, Sunday or other
           ------------                                                       
day on which commercial banks in New York City are authorized or required by law
to remain closed; provided that, when used in connection with a Eurodollar Loan,
                  --------                                                      
the term "Business Day" shall also exclude any day on which banks are not open
          ------------                                                        
for dealings in dollar deposits in the London interbank market.

          "Capital Expenditures" means, for any period, without duplication, (a)
           --------------------                                                 
the additions to property, plant and equipment and other capital expenditures
for tangible assets of Catalytica, the Borrower and the Restricted Subsidiaries
that are (or would be) set forth in a consolidated statement of cash flows of
Catalytica as additions to property, plant and equipment or other capital
expenditures for such period prepared in accordance with GAAP and (b) Capital
Lease Obligations with respect to property, plant and equipment and other
tangible assets that are incurred by Catalytica, the Borrower and the Restricted
Subsidiaries during such period.

          "Capital Lease Obligations" of any Person means the obligations of
           -------------------------                                        
such Person to pay rent or other amounts under any lease of (or other
arrangement conveying the right to use) real or personal property, or a
combination thereof, which obligations are required to be classified and
accounted for as capital leases on a balance sheet of such Person under GAAP,
and the amount of such obligations shall be the capitalized amount thereof
determined in accordance with GAAP.
<PAGE>
 
                                                                               6

          "Catalytica" means Catalytica, Inc., a Delaware corporation.
           ----------                                                 

          "Catalytica Bayview" means Catalytica Bayview, Inc., a Delaware
           ------------------                                            
corporation.

          "Catalytica Combustion" means Catalytica Combustion Systems, Inc., a
           ---------------------                                              
Delaware corporation.

          "Catalytica Combustion Release Date" means, so long as no Event of
           ----------------------------------                               
Default or Default that upon lapse of time would become an Event of Default
under paragraph (b) of Article VII has occurred and is continuing, the date on
which (a) Catalytica Combustion has received at least $10,000,000 in Net
Proceeds from the issuance after the date of this Agreement of its capital stock
to any Person other than Catalytica or its subsidiaries, (b) Catalytica
Combustion and its subsidiaries have repaid in full all Indebtedness arising
after the date of this Agreement and owed by any of them to, and returned in
full the amount of any investment made in any of them after the date of this
Agreement by, Catalytica, the Borrower or any Restricted Subsidiary (other than
Catalytica Combustion and its subsidiaries), provided that Catalytica may
                                             --------                    
instead contribute on or after the Catalytica Combustion Release Date additional
capital to Catalytica Combustion in the form of notes that evidence up to
$4,250,000 in the aggregate of intercompany loans made by Catalytica to
Catalytica Combustion and its subsidiaries after the date of this Agreement, and
(c) all Guarantees by Catalytica, the Borrower or any Restricted Subsidiary
(other than Catalytica Combustion and its subsidiaries) of obligations of
Catalytica Combustion or any of its subsidiaries (other than any such Guarantees
that (i) constitute Indebtedness permitted by Section 6.01 and (ii) are
permitted under Section 6.04(i)) shall have been irrevocably released in full.

          "CERCLA" means the Comprehensive Environmental Response, Compensation,
           ------                                                               
and Liability Act, 42 U.S.C. (S) 9601 et seq.

          "Change in Control" means (a) at any time, the acquisition of
           -----------------                                           
ownership, directly or indirectly, beneficially or of record, by any Person or
group (within the meaning of the Securities Exchange Act of 1934 and the rules
of the Securities and Exchange Commission thereunder as in effect on the date
hereof) other than MSCP and its Affiliates, of shares representing more than 30%
of the aggregate ordinary voting power represented by the issued and outstanding
capital stock of Catalytica or (b) at any time, occupation of a majority of the
seats (other than vacant seats) on the board of directors of Catalytica by
Persons who were neither (i) nominated or appointed by the board of directors of
Catalytica nor (ii) nominated or appointed by directors so nominated or
appointed.

          "Change in Law" means (a) the adoption of any law, rule or regulation
           -------------                                                       
after the date of this Agreement, (b) any change in any law, rule or regulation
or in the interpretation or application thereof by any Governmental Authority
after the date of this Agreement or (c) compliance by any Lender or the Issuing
Bank (or, for purposes of Section 2.14(b), by any lending office of such Lender
or by such Lender's or the Issuing Bank's holding company, if any) with any
request, guideline or directive (whether or not having the force of law) of any
Governmental Authority made or issued after the date of this Agreement.
<PAGE>
 
                                                                               7

          "Class", when used in reference to any Loan or Borrowing, refers to
           -----                                                             
whether such Loan, or the Loans comprising such Borrowing, are Revolving Loans
or Term Loans and, when used in reference to any Commitment, refers to whether
such Commitment is a Revolving Commitment or Term Commitment.

          "Code" means the Internal Revenue Code of 1986, as amended from time
           ----                                                               
to time.

          "Collateral" means any and all "Collateral", as defined in any
           ----------                                                   
applicable Security Document.

          "Commitment" means a Revolving Commitment or Term Commitment, or any
           ----------                                                         
combination thereof (as the context requires).

          "Commitment Letter" means the Commitment Letter dated June 25, 1997,
           -----------------                                                  
among The Chase Manhattan Bank, Chase Securities Inc. and Catalytica, Inc.

          "Consolidated Cash Interest Income" means, for any period, the cash
           ---------------------------------                                 
interest income of Catalytica, the Borrower and the Restricted Subsidiaries
during such period, determined on a consolidated basis (but excluding cash
interest income attributable to the Unrestricted Subsidiaries) in accordance
with GAAP.

          "Consolidated EBITDA" means, for any period, Consolidated Net Income
           -------------------                                                
for such period, plus, without duplication and to the extent deducted from
revenues in determining Consolidated Net Income, the sum of (a) the aggregate
amount of Consolidated Interest Expense for such period, (b) the aggregate
amount of letter of credit fees paid during such period, (c) the aggregate
amount of income tax expense for such period, (d) all amounts attributable to
depreciation, amortization and other similar non-cash charges for such period,
(e) the amount of dividends and distributions (other than loans, advances or tax
sharing payments) actually received in cash by Catalytica, the Borrower or any
of the Restricted Subsidiaries from any Unrestricted Subsidiary during such
period, (f) all amounts attributable to other non-cash charges for such period,
excluding all such charges, for purposes of this clause (f), to the extent they
relate to cash disbursements reasonably expected to be made prior to the
Maturity Date (such excluded charges, the "Excluded Non-Cash Charges") and (g)
all extraordinary charges during such period, and minus, without duplication and
to the extent added to revenues in determining Consolidated Net Income for such
period, (i) all extraordinary gains during such period and (ii) non-cash items
during such period, excluding any items that represent the reversal of any
Excluded Non-Cash Charges in any prior period, with all of the foregoing
determined on a consolidated basis (but excluding the amounts referred to in the
clauses above (except clause (e)) attributable to the Unrestricted Subsidiaries)
with respect to Catalytica, the Borrower and the Restricted Subsidiaries in
accordance with GAAP.

          "Consolidated Interest Expense" means, for any period, the interest
           -----------------------------                                     
expense, both expensed and capitalized (including the interest component in
respect of Capital Lease Obligations but excluding capitalized interest included
as a Capital Expenditure), accrued or paid by Catalytica, the Borrower and the
Restricted Subsidiaries during such period, determined on a consolidated basis
(but excluding the interest expense attributable to the Unrestricted
Subsidiaries) in accordance with GAAP.
<PAGE>
 
                                                                               8

          "Consolidated Net Income" means, for any period, net income or loss of
           -----------------------                                              
Catalytica, the Borrower and the Restricted Subsidiaries for such period
determined on a consolidated basis (but excluding net income or loss
attributable to the Unrestricted Subsidiaries) in accordance with GAAP, provided
that, except for purposes of the definition of the term "Leverage Ratio", there
shall be excluded the income (or loss) of any Person accrued prior to the date
it becomes a Subsidiary or is merged into or consolidated with Catalytica, the
Borrower or any of the Restricted Subsidiaries or the date that Person's assets
are acquired by Catalytica, the Borrower or any of the Restricted Subsidiaries.

          "Control" means the possession, directly or indirectly, of the power
           -------                                                            
to direct or cause the direction of the management or policies of a Person,
whether through the ability to exercise voting power, by contract or otherwise.
"Controlling" and "Controlled" have meanings correlative thereto.
 -----------       ----------                                    

          "Deed of Easement" means the Deed of Easement dated as of July 30,
           ----------------                                                 
1997, among the Borrower and GWI.

          "Default" means any event or condition that constitutes an Event of
           -------                                                           
Default or that upon notice, lapse of time or both would, unless cured or
waived, become an Event of Default.

          "Disclosed Matters" means the actions, suits and proceedings and the
           -----------------                                                  
environmental matters disclosed in Schedule 3.06.

          "dollars" or "$" refers to lawful money of the United States of
           -------      -                                                
America.

          "Effective Date" means July 31, 1997.
           --------------                      

          "Effectiveness Agreement" means the Effectiveness Agreement dated as
           -----------------------                                            
of June 4, 1998, among Catalytica, the Borrower, Continuing Lenders (as defined
therein), the Departing Lenders (as defined therein), the Administrative Agent,
the Collateral Agent and the Issuing Bank.

          "Environmental Laws" means all laws, rules, regulations, codes,
           ------------------                                            
ordinances, orders, decrees, judgments, injunctions, notices or binding
agreements issued, promulgated or entered into by or with any Governmental
Authority, relating in any way to the environment, preservation or reclamation
of natural resources, the handling, treatment, storage, disposal, Release or
threatened Release of any Hazardous Material or to health and safety matters
arising in connection with Hazardous Materials.

          "Environmental Liability" means any liability, contingent or otherwise
           -----------------------                                              
(including any liability for damages, natural resource damage, costs of
environmental investigation, monitoring or remediation, administrative oversight
costs, fines, penalties or indemnities), of Catalytica, the Borrower or any
Subsidiary directly or indirectly resulting from or based upon (a) violation of
any Environmental Law, (b) the generation, use, handling, transportation,
storage, treatment or disposal of any Hazardous Materials, (c) exposure to any
Hazardous Materials, (d) the Release or threatened Release of any Hazardous
Materials into the environment or (e) any contract, agreement or other
<PAGE>
 
                                                                               9

consensual arrangement pursuant to which liability is assumed or imposed with
respect to any of the foregoing.

          "Equity Financing" means (a) the contribution by MSCP to Catalytica of
           ----------------                                                     
an aggregate cash amount of not less than $120,000,000 in exchange for MSCP
Stock and (b) the contribution by Catalytica to the Borrower as common equity of
the amount so received by Catalytica.

          "ERISA" means the Employee Retirement Income Security Act of 1974, as
           -----                                                               
amended from time to time.

          "ERISA Affiliate" means any trade or business (whether or not
           ---------------                                             
incorporated) that, together with the Borrower, is treated as a single employer
under Section 414(b) or (c) of the Code or, solely for purposes of Section 302
of ERISA and Section 412 of the Code, is treated as a single employer under
Section 414 of the Code.

          "ERISA Event" means (a) any "reportable event", as defined in Section
           -----------                                                         
4043 of ERISA or the regulations issued thereunder with respect to a Plan (other
than an event for which the 30-day notice period is waived); (b) the existence
with respect to any Plan of an "accumulated funding deficiency" (as defined in
Section 412 of the Code or Section 302 of ERISA), whether or not waived; (c) the
filing pursuant to Section 412(d) of the Code or Section 303(d) of ERISA of an
application for a waiver of the minimum funding standard with respect to any
Plan; (d) the incurrence by the Borrower or any of its ERISA Affiliates of any
liability (other than for premiums under Section 4007 (a) of ERISA) under Title
IV of ERISA with respect to the termination of any Plan; (e) the receipt by the
Borrower or any ERISA Affiliate from the PBGC or a plan administrator of any
notice relating to an intention to terminate any Plan or Plans or to appoint a
trustee to administer any Plan; (f) the incurrence by the Borrower or any of its
ERISA Affiliates of any liability with respect to the withdrawal or partial
withdrawal from any Plan or Multiemployer Plan; or (g) the receipt by the
Borrower or any ERISA Affiliate of any notice, or the receipt by any
Multiemployer Plan from the Borrower or any ERISA Affiliate of any notice,
concerning the imposition of Withdrawal Liability or a determination that a
Multiemployer Plan is, or is expected to be, insolvent or in reorganization,
within the meaning of Title IV of ERISA.

          "Eurodollar", when used in reference to any Loan or Borrowing, refers
           ----------                                                          
to whether such Loan, or the Loans comprising such Borrowing, are bearing
interest at a rate determined by reference to the Adjusted LIBO Rate.

          "Event of Default" has the meaning assigned to such term in Article
           ----------------                                                  
VII.

          "Excluded Taxes" means, with respect to the Administrative Agent, any
           --------------                                                      
Lender, the Issuing Bank or any other recipient of any payment to be made by or
on account of any obligation of the Borrower hereunder, (a) income or franchise
Taxes imposed on (or measured by) its net income by the United States of
America, or by the jurisdiction under the laws of which such recipient is
organized or in which its principal office is located or, in the case of any
Lender, in which its applicable lending office is located, (b) any branch
profits Taxes imposed by the United States of America or any similar Tax imposed
by any other jurisdiction under the laws of which such recipient is organized or
in which its principal office is located or, in the case of any Lender, in which
<PAGE>
 
                                                                              10

its applicable lending office is located and (c) in the case of a Foreign Lender
(other than an assignee pursuant to a request by the Borrower under Section
2.18(b)), any withholding Tax that is imposed on amounts payable to such Foreign
Lender under this Agreement because of its failure to comply with Section
2.16(e) unless (and to the extent that) (i) such withholding Tax liability
arises or is increased by reason of a Change in Law occurring after such Foreign
Lender becomes a Lender under this Agreement or (ii) such Foreign Lender (or its
assignor, if any) was entitled, at the time of designation of a new lending
office or assignment, to receive additional amounts from the Borrower with
respect to such withholding Tax liability pursuant to Section 2.16(a).

          "Existing Indebtedness" means the principal of and interest on and all
           ---------------------                                                
other amounts (including prepayment penalties) due with respect to the Existing
Security and Loan Agreement.

          "Existing Loan and Security Agreement" means the Loan and Security
           ------------------------------------                             
Agreement dated as of November 18, 1994, among Catalytica Bayview and Silicon
Valley Bank, as amended by the Loan Modification Agreement dated as of November
30, 1995, and the Amendment to the Loan and Security Agreement dated as of
September 24, 1996.

          "Existing Preferred Stock" means (a) the 3,400,000 shares of Series A
           ------------------------                                            
Preferred Stock of the Borrower and (b) the 150,000 shares of Series B Preferred
Stock of the Borrower.

          "FD&C Act" means the Federal Drug and Cosmetic Act, as amended, and
           --------                                                          
the rules and regulations thereunder.

          "Federal Funds Effective Rate" means, for any day, the weighted
           ----------------------------                                  
average (rounded upwards, if necessary, to the next 1/100 of 1%) of the rates on
overnight Federal funds transactions with members of the Federal Reserve System
arranged by Federal funds brokers, as published on the next succeeding Business
Day by the Federal Reserve Bank of New York, or, if such rate is not so
published for any day that is a Business Day, the average (rounded upwards, if
necessary, to the next 1/100 of 1%) of the quotations for such day for such
transactions received by the Administrative Agent from three Federal funds
brokers of recognized standing selected by it.

          "Financial Officer" means the chief financial officer, principal
           -----------------                                              
accounting officer, treasurer or controller of the Borrower or of Catalytica, as
the case may be.

          "Financing Transactions" means (a) the execution, delivery and
           ----------------------                                       
performance by each Loan Party of the Loan Documents to which it is to be a
party, the borrowing of Loans and the issuance of Letters of Credit hereunder
and (b) the Equity Financing.

          "Foreign Lender" means any Lender that is organized under the laws of
           --------------                                                      
a jurisdiction other than the United States of America, a State thereof or the
District of Columbia.
<PAGE>
 
                                                                              11

          "Foreign Subsidiary" means any Subsidiary that is organized under the
           ------------------                                                  
laws of a jurisdiction other than the United States of America or any State
thereof or the District of Columbia.

          "GAAP" means generally accepted accounting principles in the United
           ----                                                              
States of America.

          "Governmental Authority" means the government of the United States of
           ----------------------                                              
America, any other nation or any political subdivision thereof, whether state or
local, and any agency, authority, instrumentality, regulatory body, court,
central bank or other entity exercising executive, legislative, judicial,
taxing, regulatory or administrative powers or functions of or pertaining to
government.

          "Guarantee" of or by any Person (the "guarantor") means any
           ---------                            ---------            
obligation, contingent or otherwise, of the guarantor guaranteeing or having the
economic effect of guaranteeing any Indebtedness or other obligation of any
other Person (the "primary obligor") in any manner, whether directly or
                   ---------------                                     
indirectly, and including any obligation of the guarantor, direct or indirect,
(a) to purchase or pay (or advance or supply funds for the purchase or payment
of) such Indebtedness or other obligation or to purchase (or to advance or
supply funds for the purchase of) any security for the payment thereof, (b) to
purchase or lease property, securities or services for the purpose of assuring
the owner of such Indebtedness or other obligation of the payment thereof, (c)
to maintain working capital, equity capital or any other financial statement
condition or liquidity of the primary obligor so as to enable the primary
obligor to pay such Indebtedness or other obligation or (d) as an account party
in respect of any letter of credit or letter of guaranty issued to support such
Indebtedness or obligation; provided that the term "Guarantee" shall not include
                            --------                                            
endorsements for collection or deposit in the ordinary course of business.

          "Guarantee Agreement" means the Guarantee Agreement, annexed hereto as
           -------------------                                                  
Exhibit E, dated as of the Effective Date, by and between the Subsidiary Loan
Parties and the Collateral Agent for the benefit of the Secured Parties, as
amended, supplemented or otherwise modified from time to time.

          "Guaranteed Revenues" shall have the meaning assigned to such term in
           -------------------                                                 
the Supply Agreement.

          "GWI" means Glaxo Wellcome Inc., a North Carolina  corporation.
           ---                                                           

          "Hazardous Materials" means all explosive or radioactive substances or
           -------------------                                                  
wastes and all hazardous or toxic substances, wastes or other pollutants,
including petroleum or petroleum distillates, asbestos or asbestos containing
materials, polychlorinated biphenyls, radon gas, infectious or medical wastes
and all other substances or wastes of any nature regulated pursuant to any
Environmental Law, including any material listed as a hazardous substance under
Section 101(14) of CERCLA.

          "Hedging Agreement" means any interest rate protection agreement,
           -----------------                                               
foreign currency exchange agreement, commodity price protection agreement or
other interest or currency exchange rate or commodity price hedging arrangement.
<PAGE>
 
                                                                              12

          "Inactive Subsidiary" means any Subsidiary that (a) has total assets
           -------------------                                                
not in excess of $50,000, (b) conducts no business and (c) has no Indebtedness
other than (in the case of Advanced Sensor) Indebtedness owed to a Loan Party.

          "Indebtedness" of any Person means, without duplication, (a) all
           ------------                                                   
obligations of such Person for borrowed money or with respect to deposits or
advances of any kind, (b) all obligations of such Person evidenced by bonds,
debentures, notes or similar instruments, (c) all obligations of such Person
under conditional sale or other title retention agreements relating to property
acquired by such Person, (d) all obligations of such Person incurred, issued or
assumed as the deferred purchase price of property or services (excluding
current accounts payable incurred in the ordinary course of business and the
Sterile Facility Pay-Out), (e) all Indebtedness of others secured by (or for
which the holder of such Indebtedness has an existing right, contingent or
otherwise, to be secured by) any Lien on property owned or acquired by such
Person, whether or not the Indebtedness secured thereby has been assumed
(provided that if the obligations so secured have not been assumed by such
Person, such obligations shall be deemed to be in an amount equal to the lesser
of (i) the fair market value of such property, as determined in good faith by
the board of directors of such Person, and (ii) the amount of such obligations),
(f) all Guarantees by such Person of Indebtedness of others, (g) all Capital
Lease Obligations of such Person, (h) all obligations, contingent or otherwise,
of such Person as an account party in respect of letters of credit and letters
of guaranty and (i) all obligations, contingent or otherwise, of such Person in
respect of bankers' acceptances. The Indebtedness of any Person shall include
the Indebtedness of any other entity (including any partnership in which such
Person is a general partner) to the extent such Person is legally liable
therefor as a result of such Person's ownership interest in or other
relationship with such entity, except to the extent the terms of such
Indebtedness provide that such Person is not liable therefor.

          "Indemnified Taxes" means Taxes other than Excluded Taxes.
           -----------------                                        

          "Indemnity, Subrogation and Contribution Agreement" means the
           -------------------------------------------------           
Indemnity, Subrogation and Contribution Agreement, annexed hereto as Exhibit F,
dated as of the Effective Date, among the Borrower, the Subsidiary Loan Parties
and the Collateral Agent, as amended, supplemented or otherwise modified from
time to time.

          "Information Memorandum" means the Confidential Information Memorandum
           ----------------------                                               
of the Borrower dated May 1998.

          "Interest Election Request" means a request by the Borrower to convert
           -------------------------                                            
or continue a Revolving Borrowing or Term Borrowing in accordance with Section
2.06.

          "Interest Payment Date" means (a) with respect to any ABR Loan, the
           ---------------------                                             
last Business Day of each March, June, September and December and (b) with
respect to any Eurodollar Loan, the last day of the Interest Period applicable
to the Borrowing of which such Loan is a part and, in the case of a Eurodollar
Borrowing with an Interest Period of more than three months' duration, each
Business Day prior to the last day of such Interest Period that occurs at
intervals of three months' duration after the first day of such Interest Period.
<PAGE>
 
                                                                              13

          "Interest Period" means, with respect to any Eurodollar Borrowing, the
           ---------------                                                      
period commencing on the date of such Borrowing and ending on the numerically
corresponding day in the calendar month that is one, two, three or six months
thereafter or, subject to availability from all Lenders as determined by the
Administrative Agent, nine or twelve months thereafter, as the Borrower may
elect; provided, that (i) if any Interest Period would end on a day other than a
       --------                                                                 
Business Day, such Interest Period shall be extended to the next succeeding
Business Day unless such next succeeding Business Day would fall in the next
calendar month, in which case such Interest Period shall end on the next
preceding Business Day and (ii) any Interest Period that commences on the last
Business Day of a calendar month (or on a day for which there is no numerically
corresponding day in the last calendar month of such Interest Period) shall end
on the last Business Day of the last calendar month of such Interest Period.
For purposes hereof, the date of a Borrowing initially shall be the date on
which such Borrowing is made and thereafter shall be the effective date of the
most recent Interest Rate Election for such Borrowing.

          "Investment Agreement" means the Investment Agreement dated as of June
           --------------------                                                 
25, 1997, between Catalytica and MSCP.

          "Issuing Bank" means The Chase Manhattan Bank, in its capacity as the
           ------------                                                        
issuer of Letters of Credit hereunder, and its successors in such capacity as
provided in Section 2.04(i).  The Issuing Bank may, in its discretion, arrange
for one or more Letters of Credit to be issued by Affiliates of the Issuing
Bank, in which case the term "Issuing Bank" shall include any such Affiliate
with respect to Letters of Credit issued by such Affiliate; provided that, at
                                                            --------         
the time any such Letter of Credit is issued by any such Affiliate, demand
deposits made with such Affiliate shall have a credit rating of not less than
the credit rating of demand deposits made with The Chase Manhattan Bank.

          "Junior Preferred Purchase Agreement" means the Stock Purchase
           -----------------------------------                          
Agreement dated as of June 25, 1997, among the Borrower, Catalytica and GWI.

          "Junior Preferred Stock" means the Series 1 Junior Preferred Stock of
           ----------------------                                              
the Borrower.

          "LC Availability Period" means the period from and including the
           ----------------------                                         
Effective Date to but excluding the earlier of (a) the date that is five
Business Days prior to the Maturity Date and (b) the date of termination of the
Revolving Commitments.

          "LC Disbursement" means a payment made by the Issuing Bank pursuant to
           ---------------                                                      
a Letter of Credit.

          "LC Exposure" means, at any time, the sum of (a) the aggregate undrawn
           -----------                                                          
amount of all outstanding Letters of Credit at such time plus (b) the aggregate
amount of all LC Disbursements that have not yet been reimbursed (from the
proceeds of a Borrowing or otherwise) by or on behalf of the Borrower at such
time.  The LC Exposure of any Revolving Lender at any time shall be its
Applicable Percentage of the total LC Exposure at such time.

          "Lenders" means the Persons listed on Schedule 2.01 and any other
           -------                                                         
Person that shall have become a party hereto pursuant to an Assignment and
Acceptance 
<PAGE>
 
                                                                              14

permitted under Section 9.04, other than any such Person that ceases to be a
party hereto pursuant to an Assignment and Acceptance.

          "Letter of Credit" means any letter of credit issued pursuant to this
           ----------------                                                    
Agreement.

          "Leverage Ratio" means, on any date, the ratio of (a) Total Debt as of
           --------------                                                       
such date minus cash and Permitted Investments in excess of $1,000,000 set forth
          -----                                                                 
(or that would be set forth) on a consolidated balance sheet (but excluding the
cash and Permitted Investments attributable to the Unrestricted Subsidiaries) of
Catalytica, the Borrower and the Restricted Subsidiaries as of such date to (b)
Adjusted Consolidated EBITDA for the period of four consecutive fiscal quarters
(except as otherwise specified in Section 6.14(a) or (b)) of Catalytica most
recently ended as of such date, all determined on a consolidated basis in
accordance with GAAP.

          "LIBO Rate" means, with respect to any Eurodollar Borrowing for any
           ---------                                                         
Interest Period, the rate appearing on Page 3750 of the Telerate Service (or on
any successor or substitute page of such Service, or any successor to or
substitute for such Service, providing rate quotations comparable to those
currently provided on such page of such Service, as determined by the
Administrative Agent from time to time for purposes of providing quotations of
interest rates applicable to dollar deposits in the London interbank market) at
approximately 11:00 a.m., London time, two Business Days prior to the
commencement of such Interest Period, as the rate for dollar deposits with a
maturity comparable to such Interest Period.  In the event that such rate is not
available at such time for any reason, then the "LIBO Rate" with respect to such
                                                 ---------                      
Eurodollar Borrowing for such Interest Period shall be the rate at which dollar
deposits of $5,000,000 and for a maturity comparable to such Interest Period are
offered by the principal London office of the Administrative Agent in
immediately available funds in the London interbank market at approximately
11:00 a.m., London time, two Business Days prior to the commencement of such
Interest Period.

          "Lien" means, with respect to any asset, (a) any mortgage, deed of
           ----                                                             
trust, lien, pledge, hypothecation, encumbrance, charge or security interest in,
on or of such asset, (b) the interest of a vendor or a lessor under any
conditional sale agreement, capital lease or title retention agreement (or any
financing lease having substantially the same economic effect as any of the
foregoing) relating to such asset and (c) in the case of securities, any
purchase option, call or similar right of a third party with respect to such
securities.

          "Loan Documents" means this Agreement, the Effectiveness Agreement,
           --------------                                                    
the Letters of Credit, the Parent Guarantee Agreement, the Guarantee Agreement,
the Indemnity, Subrogation and Contribution Agreement, the Reaffirmation
Agreement and the Security Documents.

          "Loan Parties" means Catalytica, the Borrower and the Subsidiary Loan
           ------------                                                        
Parties.

          "Loans" means the loans made and to be made by the Lenders to the
           -----                                                           
Borrower pursuant to this Agreement.
<PAGE>
 
                                                                              15

          "Margin Stock" shall have the meaning assigned to such term in
           ------------                                                 
Regulation U.

          "Material Adverse Effect" means a material adverse effect on (a) the
           -----------------------                                            
business, assets, operations, properties, financial condition, contingent
liabilities (including but not limited to potential environmental liabilities),
prospects or material agreements of or relating to Catalytica, the Borrower and
the Restricted Subsidiaries taken as a whole, (b) the ability of any Loan Party
to perform any of its material obligations under any Loan Document or (c) the
material rights of or benefits available to the Lenders under any Loan Document.

          "Material GWI Occupancy" means, as of the date of any Borrowing, that
           ----------------------                                              
(a) GWI has been occupying a portion of the Acquired Facilities pursuant to the
Deed of Easement for a period of at least fifteen consecutive days immediately
prior to the date of such Borrowing and, as a result thereof, the Guaranteed
Revenues could reasonably be expected to be reduced by at least $10,000,000,
taking into reasonable account all pertinent factors, and (b) the Guaranteed
Revenues that are to be paid after such date exceed $50,000,000.

          "Material Indebtedness" means Indebtedness (other than the Loans and
           ---------------------                                              
Letters of Credit), or obligations in respect of one or more Hedging Agreements,
of any one or more of Catalytica, the Borrower and the Restricted Subsidiaries
in an aggregate principal amount exceeding $3,000,000.  For purposes of
determining Material Indebtedness, the "principal amount" of the obligations of
Catalytica, the Borrower or any Restricted Subsidiary in respect of any Hedging
Agreement at any time shall be the maximum aggregate amount (giving effect to
any netting agreements) that Catalytica, the Borrower or such Restricted
Subsidiary would be required to pay if such Hedging Agreement were terminated at
such time.

          "Maturity Date" means June 4, 2003.
           -------------                     

          "Moody's" means Moody's Investors Service, Inc.
           -------                                       

          "Mortgage" means a mortgage, deed of trust, assignment of leases and
           --------                                                           
rents, leasehold mortgage or other security document, substantially in the form
of Exhibit I, granting a Lien on any Mortgaged Property to secure the
Obligations.  Each Mortgage shall be satisfactory in form and substance to the
Administrative Agent.

          "Mortgaged Property" means, initially, each parcel of real property
           ------------------                                                
and the improvements thereto owned by a Loan Party (other than a Non-Borrower
Subsidiary) that is identified on Schedule 1.01(a), and includes each other
parcel of real property and improvements thereto with respect to which a
Mortgage is granted pursuant to Section 5.12 or 5.13.

          "MSCP" means (a) Morgan Stanley Capital Partners III, L.P., a Delaware
           ----                                                                 
limited partnership, (b) MSCP III 892 Investors L.P., a Delaware limited
partnership, and (c) Morgan Stanley Capital Investors, L.P., a Delaware limited
partnership.

          "MSCP Stock" means convertible Class A Common Stock and Class B Common
           ----------                                                           
Stock issued by Catalytica to MSCP pursuant to the Investment Agreement.
<PAGE>
 
                                                                              16

          "Multiemployer Plan" means a multiemployer plan as defined in Section
           ------------------                                                  
4001(a)(3) of ERISA.

          "Net Proceeds" means, with respect to any event or series of related
           ------------                                                       
events (other than (1) any sale, transfer or other disposition or any series of
related sales, transfers or other dispositions of any property or assets if the
aggregate proceeds from such sale, transfer or other disposition or from such
series of related sales, transfers or other dispositions are not in excess of
$500,000 and (2) other dispositions resulting in aggregate proceeds of not in
excess of $2,000,000 in any fiscal year)  (a) the cash proceeds received in
respect of such event or series of events, including (i) any cash received in
respect of any non-cash proceeds, but only as and when received, (ii) in the
case of a casualty, insurance proceeds in excess of $2,000,000, and (iii) in the
case of a condemnation or similar event, condemnation awards and similar
payments in excess of $2,000,000; in each case net of (b) the sum of (i) all
fees and out-of-pocket expenses reasonably incurred (and payable during the year
in which such event occurred or the next succeeding year) or paid by Catalytica,
the Borrower and/or the Restricted Subsidiaries to third parties in connection
with such event, (ii) in the case of a sale, transfer or other disposition of an
asset (including pursuant to a sale and leaseback transaction or a casualty or
other insured damage or condemnation or similar proceeding), the amount of all
payments required to be made by Catalytica, the Borrower and the Restricted
Subsidiaries as a result of such event to repay Indebtedness (other than Loans)
secured by such asset or otherwise subject to mandatory prepayment as a result
of such event, and (iii) the amount of all taxes that are directly attributable
to such event and are paid (or reasonably estimated to be payable) by
Catalytica, the Borrower and/or the Restricted Subsidiaries, and the amount of
any reserves established by Catalytica, the Borrower and/or the Restricted
Subsidiaries to fund contingent liabilities reasonably estimated to be payable
in connection with such event, in each case during the year in which such event
occurred or the next succeeding year (as determined reasonably and in good faith
by the chief financial officer of the Borrower, provided that, to the extent and
                                                --------                        
at the time any such unexpended amounts are released from any such reserve, such
amounts shall constitute Net Proceeds); provided, however, that, with respect to
                                        --------  -------                       
any sale, transfer or other disposition of an asset (including pursuant to a
sale and leaseback transaction or, subject to Section 5.08, a casualty or other
insured damage or condemnation or similar proceeding), if (A) the Borrower
intends, and (B) in the case of any such sale, transfer or other disposition the
proceeds of which exceed $5,000,000, the Borrower delivers a certificate of a
Financial Officer to the Administrative Agent at the time of such sale, transfer
or other disposition setting forth the Borrower's intent, to use the proceeds of
such sale, transfer or other disposition to acquire or repair assets to be used
in the same line of business within 365 days of receipt of such proceeds, and no
Event of Default shall have occurred and shall be continuing at the time of such
sale, transfer or other disposition or at the proposed time of the application
of such proceeds, such proceeds shall not constitute Net Proceeds except (x) to
the extent not so used at the end of such 365-day period or (y) in the case of
insurance proceeds from a casualty, if the Borrower shall deliver a certificate
of a Financial Officer to the Administrative Agent before the end of such 365-
day period certifying that the Borrower has begun (and is diligently proceeding
with) repairing, restoring or replacing such assets within 365 days after the
end of the first such 365-day period, to the extent such proceeds are not so
used at the end of such second 365-day period, at which time such proceeds shall
be deemed Net Proceeds at the end of the second such 365-day period.
<PAGE>
 
                                                                              17

          "Non-Borrower Subsidiary" means any Subsidiary other than any
           -----------------------                                     
Subsidiary of the Borrower.

          "Obligations" has the meaning assigned to such term in (a) the
           -----------                                                  
Security Agreement and (b) the Pledge Agreement.

          "Operating Lease" means, as applied to any Person, any lease
           ---------------                                            
(including leases that may be terminated by the lessee at any time) by such
person of any property (whether real, personal or mixed) that is not required to
be classified and accounted for as a capital lease on such person's balance
sheet in accordance with GAAP, other than any such lease under which such person
is the lessor.

          "Original Credit Agreement" has the meaning assigned to such term in
           -------------------------                                          
the first paragraph of the preliminary statement of this Agreement.

          "Other Taxes" means any and all current or future stamp or documentary
           -----------                                                          
taxes or any other excise or property taxes, charges or similar levies arising
from any payment made under any Loan Document or from the execution, delivery or
enforcement of, or otherwise with respect to, any Loan Document.

          "Parent Guarantee Agreement" means the Parent Guarantee Agreement,
           --------------------------                                       
annexed hereto as Exhibit D, dated as of the Effective Date, by and between
Catalytica and the Collateral Agent for the benefit of the Secured Parties, as
amended, supplemented or otherwise modified from time to time.

          "PBGC" means the Pension Benefit Guaranty Corporation referred to and
           ----                                                                
defined in ERISA and any successor entity performing similar functions.

          "Perfection Certificate" means a certificate in the form of Annex 2 to
           ----------------------                                               
the Security Agreement or any other form approved by the Administrative Agent.

          "Permitted Encumbrances" means:
           ----------------------        

          (a) Liens imposed by law for Taxes that are not yet delinquent or are
     being contested in compliance with Section 5.04;

          (b) carriers', warehousemen's, mechanics', materialmen's, repairmen's
     and other like Liens imposed by law, arising in the ordinary course of
     business and securing obligations that are not overdue by more than 30 days
     or are being contested in compliance with Section 5.04;

          (c) pledges and deposits made in the ordinary course of business in
     compliance with workers' compensation, unemployment insurance and other
     social security laws and other similar laws and regulations;

          (d) deposits to secure the performance of bids, trade contracts,
     leases, statutory obligations, surety and appeal bonds, performance bonds
     and other obligations of a like nature, in each case in the ordinary course
     of business;
<PAGE>
 
                                                                              18

          (e) judgment liens in respect of judgments that do not constitute an
     Event of Default under clause (k) of Article VII;

          (f) easements, zoning restrictions, restrictions on use, rights-of-
     way, encumbrances not securing monetary obligations and covered by title
     insurance and similar encumbrances on real property imposed by law or
     arising in the ordinary course of business that do not secure any monetary
     obligations and do not materially detract from the value of the affected
     property or materially interfere with the ordinary conduct of business of
     Catalytica, the Borrower or any Restricted Subsidiary;

          (g) Liens of sellers of goods arising under Article 2 of the Uniform
     Commercial Code or other provisions of applicable law in the ordinary
     course of business, covering only the goods sold and securing only the
     unpaid purchase price therefor; and

          (h) exceptions and encumbrances covered in Schedule B to title
     insurance policies being issued to insure the Lien of each Mortgage.

provided that the term "Permitted Encumbrances" shall not include any Lien
- --------                                                                  
securing Indebtedness.

          "Permitted Investments" means:
           ---------------------        

          (a) direct obligations of, or obligations the principal of and
     interest on which are unconditionally guaranteed by, the United States of
     America (or by any agency thereof to the extent such obligations are backed
     by the full faith and credit of the United States of America), in each case
     maturing within one year from the date of acquisition thereof;

          (b) investments in commercial paper maturing within 270 days from the
     date of acquisition thereof and having, at such date of acquisition, a
     credit rating of A1 or better from S&P or P1 or better from Moody's;

          (c) investments in certificates of deposit, banker's acceptances and
     time deposits maturing within one year from the date of acquisition thereof
     issued or guaranteed by or placed with, and money market deposit accounts
     issued or offered by, any domestic office of any commercial bank that has a
     combined capital and surplus and undivided profits of not less than
     $250,000,000 or a rating of A1 or better from S&P or P1 or better from
     Moody's;

          (d) readily marketable direct obligations of any State of the United
     States of America or any political subdivision of any such State having, at
     such date of acquisition, a rating of at least AA by S&P and Aa2 by
     Moody's, in each case maturing within one year after the date of
     acquisition thereof;

          (e) fully collateralized repurchase agreements with a term of not more
     than 30 days for securities described in clause (a) above and entered into
     with a financial institution (whether or not a commercial bank) satisfying
     the criteria described in clause (c) above; and
<PAGE>
 
                                                                              19

          (f) other investment instruments approved in writing by the Required
     Lenders.

          "Person" means any natural person, corporation, limited liability
           ------                                                          
company, trust, joint venture, association, company, limited partnership,
partnership, Governmental Authority or other entity.

          "Pfizer" means Pfizer, Inc., a Delaware corporation.
           ------                                             

          "Plan" means any employee pension benefit plan (other than a
           ----                                                       
Multiemployer Plan) subject to the provisions of Title IV of ERISA or Section
412 of the Code or Section 302 of ERISA, and in respect of which the Borrower or
any ERISA Affiliate is (or, if such plan were terminated, would under Section
4069 of ERISA be deemed to be) an "employer" as defined in Section 3(5) of
ERISA.

          "Pledge Agreement" means the Pledge Agreement, annexed hereto as
           ----------------                                               
Exhibit G, dated as of the Effective Date, as amended by the Reaffirmation
Agreement, among Catalytica, the Borrower, the Restricted Subsidiaries that are
party thereto and the Collateral Agent for the benefit of the Secured Parties,
as amended, supplemented or otherwise modified from time to time.

          "Prepayment Event" means:
           ----------------        

          (a) any sale, transfer or other disposition (including pursuant to a
     sale and leaseback transaction) of any property or asset of Catalytica, the
     Borrower or any Restricted Subsidiary, other than dispositions described in
     Section 6.05 (other than Section 6.05(c)); or

          (b) any casualty or other insured damage to, or any taking under power
     of eminent domain or by condemnation or similar proceeding of, any property
     or asset of Catalytica, the Borrower or any Restricted Subsidiary; or

          (c) the incurrence by Catalytica, the Borrower or any Restricted
     Subsidiary of any Indebtedness, other than Indebtedness permitted by
     Section 6.01(a).

          "Prime Rate" means the rate of interest per annum publicly announced
           ----------                                                         
from time to time by The Chase Manhattan Bank as its prime rate in effect at its
principal office in New York City; each change in the Prime Rate shall be
effective from and including the date such change is publicly announced as being
effective.

          "Reaffirmation Agreement" means the Reaffirmation Agreement,
           -----------------------                                    
substantially in the form of Exhibit K, among Catalytica, the Borrower, the
Restricted Subsidiaries that are party thereto and the Administrative Agent and
Collateral Agent for the benefit of the Secured Parties.

          "Register" has the meaning set forth in Section 9.04(c).
           --------                                               

          "Regulation U" shall mean Regulation U of the Board as from time to
           ------------                                                      
time in effect and all official rulings and interpretations thereunder or
thereof.
<PAGE>
 
                                                                              20

          "Regulation X" shall mean Regulation X of the Board as from time to
           ------------                                                      
time in effect and all official rulings and interpretations thereunder or
thereof.

          "Related Parties" means, with respect to any specified Person, such
           ---------------                                                   
Person's Affiliates and the respective directors, officers, employees, agents
and advisors of such Person and of such Person's Affiliates.

          "Release" has the meaning set forth in Section 101(22) of CERCLA.
           -------                                                         

          "Required Lenders" means, at any time, Lenders having Revolving
           ----------------                                              
Exposures, Term Loans and unused Commitments representing more than 50% of the
sum of the total Revolving Exposures, outstanding Term Loans and unused
Commitments at such time.

          "Restatement Date" means the Restatement Date as defined in the
           ----------------                                              
Effectiveness Agreement.

          "Restricted Payment" means any dividend or other distribution (whether
           ------------------                                                   
in cash, securities or other property) with respect to any shares of any class
of capital stock of Catalytica, the Borrower or any Restricted Subsidiary, or
any payment (whether in cash, securities or other property), including any
sinking fund or similar deposit, on account of the purchase, redemption,
retirement, acquisition, cancelation or termination of (a) any such shares of
capital stock of Catalytica, the Borrower or any Restricted Subsidiary or (b)
any option, warrant or other right to acquire any such shares of capital stock
of Catalytica, the Borrower or any Restricted Subsidiary.

          "Restricted Subsidiary" means (a) prior to the Catalytica Combustion
           ---------------------                                              
Release Date, any Subsidiary and (b) after the Catalytica Combustion Release
Date, any Subsidiary that is not an Unrestricted Subsidiary.

          "Revolving Availability Period" means the period from and including
           -----------------------------                                     
the Effective Date to but excluding the earlier of the Maturity Date and the
date of termination of the Revolving Commitments.

          "Revolving Commitment" means, with respect to each Lender, the
           --------------------                                         
commitment, if any, of such Lender to make Revolving Loans and to acquire
participations in Letters of Credit hereunder, expressed as an amount
representing the maximum aggregate amount of such Lender's Revolving Exposure
hereunder, as such commitment may be (a) reduced from time to time pursuant to
Section 2.08 and (b) reduced or increased from time to time pursuant to
assignments by or to such Lender pursuant to Section 9.04.  The amount of each
Lender's Revolving Commitment as of the Restatement Date or as of the date such
Lender became a Revolving Lender, as applicable, is set forth on Schedule 2.01,
or in the Assignment and Acceptance pursuant to which such Lender shall have
assumed its Revolving Commitment, as applicable.  The aggregate amount of the
Lenders' Revolving Commitments as of the Restatement Date is $100,000,000.

          "Revolving Exposure" means, with respect to any Lender at any time,
           ------------------                                                
the sum of the outstanding principal amount of such Lender's Revolving Loans and
its LC Exposure at such time.
<PAGE>
 
                                                                              21

          "Revolving Lender" means a Lender with a Revolving Commitment or, if
           ----------------                                                   
the Revolving Commitments have terminated or expired, a Lender with Revolving
Exposure.

          "Revolving Loan" means a Loan made pursuant to clause (b) of Section
           --------------                                                     
2.01.

          "S&P" means Standard & Poor's Ratings Service.
           ---                                          

          "Secured Parties" shall have the meaning assigned to such term in the
           ---------------                                                     
Security Agreement.

          "Security Agreement" means the Security Agreement, annexed hereto as
           ------------------                                                 
Exhibit H, dated as of the Effective Date, as amended by the Reaffirmation
Agreement, among Catalytica, the Borrower, each Subsidiary Loan Party that is a
Subsidiary of the Borrower and the Collateral Agent for the benefit of the
Secured Parties, as amended, supplemented or otherwise modified from time to
time.

          "Security Documents" means the Security Agreement, the Pledge
           ------------------                                          
Agreement, the Mortgages and each other security agreement or other instrument
or document executed and delivered pursuant to Section 5.12 or 5.13 to secure
any of the Obligations.

          "Share Exchange Agreement" means the share exchange agreement dated as
           ------------------------                                             
of June 25, 1997, among Catalytica, the Borrower and GWI.

          "Sold Entity or Business" has the meaning assigned to such term in the
           -----------------------                                              
definition of Adjusted Consolidated EBITDA.

          "Statutory Reserve Rate" means a fraction (expressed as a decimal),
           ----------------------                                            
the numerator of which is the number one and the denominator of which is the
number one minus the aggregate of the maximum reserve percentages (including any
marginal, special, emergency or supplemental reserves) expressed as a decimal
established by the Board to which the Administrative Agent is subject (a) with
respect to the Base CD Rate, for new negotiable nonpersonal time deposits in
dollars of over $100,000 with maturities approximately equal to three months and
(b) with respect to the Adjusted LIBO Rate, for eurocurrency funding (currently
referred to as "Eurocurrency Liabilities" in Regulation D of the Board).  Such
reserve percentages shall include those imposed pursuant to such Regulation D or
any successor regulation or law.  Eurodollar Loans shall be deemed to constitute
eurocurrency funding and to be subject to such reserve requirements without
benefit of or credit for proration, exemptions or offsets that may be available
from time to time to any Lender under such Regulation D or any comparable
regulation.  The Statutory Reserve Rate shall be adjusted automatically on and
as of the effective date of any change in any reserve percentage.

          "Sterile Facility Pay-Out" means the Borrower's payments to GWI from
           ------------------------                                           
time to time after the Effective Date of an aggregate amount of up to
$25,000,000, as provided in Exhibit F to the Asset Purchase Agreement; provided
                                                                       --------
that such payments shall be subject to the limitations set forth in Section
6.11.
<PAGE>
 
                                                                              22

          "Sterile Products Facility" means the building included in the
           -------------------------                                    
Acquired Facilities used predominantly for the manufacture of sterile products.

          "Subordinated Indebtedness" means any Indebtedness of the Borrower or
           -------------------------                                           
any Restricted Subsidiary that is subordinated in any manner in right of payment
to any of the Obligations.

          "Subsidiary" means, with respect to any Person (the "parent") at any
           ----------                                          ------         
date, any corporation, limited liability company, limited partnership,
partnership, association or other entity the accounts of which would be
consolidated with those of the parent in the parent's consolidated financial
statements if such financial statements were prepared in accordance with GAAP as
of such date, as well as any other corporation, limited liability company,
limited partnership, partnership, association or other entity (a) of which
securities or other ownership interests representing more than 50% of the equity
or more than 50% of the ordinary voting power or, in the case of a partnership,
more than 50% of the general partnership interests are, as of such date, owned,
controlled or held, or (b) that is, as of such date, otherwise Controlled, by
the parent or one or more subsidiaries of the parent or by the parent and one or
more subsidiaries of the parent.

          "Subsidiary" means any Subsidiary of Catalytica other than the
           ----------                                                   
Borrower, provided, however, that Genxon/tm Power Systems, LLC shall be deemed
          --------  -------                                                   
not to be a Subsidiary.

          "Subsidiary Loan Party" means any Subsidiary that is not (a) a Foreign
           ---------------------                                                
Subsidiary or (b) an Inactive Subsidiary, provided, however, that Catalytica
                                          --------  -------                 
Combustion and its subsidiaries shall be deemed not to be Subsidiary Loan
Parties after the Catalytica Combustion Release Date.

          "Supply Agreement" means the Supply Agreement dated as of July 31,
           ----------------                                                 
1997, among Catalytica, the Borrower and GWI.

          "Taxes" means any and all present or future taxes, levies, imposts,
           -----                                                             
duties, deductions, charges or withholdings imposed by any Governmental
Authority.

          "Term Commitment" means, with respect to each Lender, the commitment,
           ---------------                                                     
if any, of such Lender to make a Term Loan pursuant to the Original Credit
Agreement.

          "Term Loan" means a Loan made pursuant to clause (a) of Section 2.01
           ---------                                                          
of the Original Credit Agreement.

          "Term Loan Lender" means a Lender with a Term Commitment or an
           ----------------                                             
outstanding Term Loan.

          "Three-Month Secondary CD Rate" means, for any day, the secondary
           -----------------------------                                   
market rate for three-month certificates of deposit reported as being in effect
on such day (or, if such day is not a Business Day, the next preceding Business
Day) by the Board through the public information telephone line of the Federal
Reserve Bank of New York (which rate will, under the current practices of the
Board, be published in Federal Reserve Statistical Release H.15(519) during the
week following such day) or, if such rate is not 
<PAGE>
 
                                                                              23

so reported on such day or such next preceding Business Day, the average of the
secondary market quotations for three-month certificates of deposit of major
money center banks in New York City received at approximately 10:00 a.m., New
York City time, on such day (or, if such day is not a Business Day, on the next
preceding Business Day) by the Administrative Agent from three negotiable
certificate of deposit dealers of recognized standing selected by it.

          "Total Debt" means, as of any date of determination, without
           ----------                                                 
duplication, the aggregate principal amount of Indebtedness of Catalytica, the
Borrower and the Restricted Subsidiaries outstanding as of such date, determined
on a consolidated basis (but excluding the Indebtedness attributable to the
Unrestricted Subsidiaries) in accordance with GAAP (other than Indebtedness of
the type referred to in clause (h) of the definition of the term "Indebtedness",
except to the extent of any unreimbursed drawings thereunder).

          "Transactions" means the Acquisition, the Financing Transactions, the
           ------------                                                        
execution of the Supply Agreement, the Advisory Compensation and the other
transactions contemplated by the Acquisition Documents.

          "Type", when used in reference to any Loan or Borrowing, refers to
           ----                                                             
whether the rate of interest on such Loan, or on the Loans comprising such
Borrowing, is determined by reference to the Adjusted LIBO Rate or the Alternate
Base Rate.

          "Unrestricted Subsidiary" means, after the Catalytica Combustion
           -----------------------                                        
Release Date, Catalytica Combustion and each of its subsidiaries.

          "Warrant Purchase Agreement" means the Warrant Purchase Agreement
           --------------------------                                      
dated as of June 25, 1997, among Catalytica, the Borrower and GWI.

          "Warrants" means the warrants to purchase 2,000,000 shares of
           --------                                                    
Catalytica's common stock issued to GWI pursuant to the Warrant Purchase
Agreement.

          "Withdrawal Liability" means liability to a Multiemployer Plan as a
           --------------------                                              
result of a complete or partial withdrawal from such Multiemployer Plan, as such
terms are defined in Part I of Subtitle E of Title IV of ERISA.

          SECTION 1.02.  Classification of Loans and Borrowings.  For purposes
                         ---------------------------------------              
of this Agreement, Loans may be classified and referred to by Class (e.g., a
                                                                     ----   
"Revolving Loan") or by Type (e.g., a "Eurodollar Loan") or by Class and Type
                              ----                                           
(e.g., a "Eurodollar Revolving Loan").  Borrowings also may be classified and
- -----                                                                        
referred to by Class (e.g., a "Revolving Borrowing") or by Type (e.g., a
                      ----                                       ----   
"Eurodollar Borrowing") or by Class and Type (e.g., a "Eurodollar Revolving
                                              ----                         
Borrowing").

          SECTION 1.03.  Terms Generally.  The definitions of terms herein shall
                         ----------------                                       
apply equally to the singular and plural forms of the terms defined.  Whenever
the context may require, any pronoun shall include the corresponding masculine,
feminine and neuter forms.  The words "include", "includes" and "including"
shall be deemed to be followed by the phrase "without limitation".  The word
"will" shall be construed to have the same meaning and effect as the word
"shall".  Unless the context requires otherwise (a) any definition of or
reference to any agreement, instrument or other document herein shall be
<PAGE>
 
                                                                              24

construed as referring to such agreement, instrument or other document as from
time to time amended, supplemented or otherwise modified (subject to any
restrictions on such amendments, supplements or modifications set forth herein),
(b) any reference herein to any Person shall be construed to include such
Person's successors and permitted assigns, (c) the words "herein", "hereof" and
"hereunder", and words of similar import, shall be construed to refer to this
Agreement in its entirety and not to any particular provision hereof, (d) unless
otherwise more definitely identified, all references herein to Articles,
Sections, Exhibits and Schedules shall be construed to refer to Articles and
Sections of, and Exhibits and Schedules to, this Agreement and (e) the words
"asset" and "property" shall be construed to have the same meaning and effect
and to refer to any and all tangible and intangible assets and properties,
including cash, securities, accounts and contract rights.

          SECTION 1.04.  Accounting Terms; GAAP.  Except as otherwise expressly
                         -----------------------                               
provided herein, all terms of an accounting or financial nature shall be
construed in accordance with GAAP, as in effect from time to time; provided
                                                                   --------
that, if the Borrower notifies the Administrative Agent that the Borrower
requests an amendment to any provision hereof to eliminate the effect of any
change occurring after the date hereof in GAAP or in the application thereof on
the operation of such provision (or if the Administrative Agent notifies the
Borrower that the Required Lenders request an amendment to any provision hereof
for such purpose), regardless of whether any such notice is given before or
after such change in GAAP or in the application thereof, then such provision
shall be interpreted on the basis of GAAP as in effect and applied immediately
before such change shall have become effective until such notice shall have been
withdrawn or such provision amended in accordance herewith.


                                   ARTICLE II

                                  The Credits
                                  -----------

          SECTION 2.01.  Redesignation of $25,000,000 of Loans; Commitments. (a)
                         ---------------------------------------------------
On the Restatement Date, $25,000,000 of the Term Loans outstanding under the
Original Credit Agreement immediately prior to the Restatement Date shall be
redesignated as Revolving Loans and the Revolving Commitments shall be increased
by $25,000,000 in the aggregate such that, after giving effect to such
redesignation of Loans and such increase of Commitments, the outstanding Term
Loans and Revolving Loans and the Revolving Commitment for each Lender shall be
as described on Schedule 2.01.

          (b)  No Lender shall have an obligation to make any additional Term
Loans, other than Term Loans made pursuant to continuations or conversions of
Term Loans outstanding on the Restatement Date.  Amounts repaid in respect of
the Term Loans may not be reborrowed.

          (c)  Subject to the terms and conditions set forth herein, each Lender
agrees to make Revolving Loans to the Borrower from time to time during the
Revolving Availability Period in an aggregate principal amount that will not
result in such Lender's Revolving Exposure exceeding such Lender's Revolving
Commitment.  Within the foregoing limits and subject to the terms and conditions
set forth herein, the Borrower may borrow, prepay and reborrow Revolving Loans.
<PAGE>
 
                                                                              25

          SECTION 2.02.  Loans and Borrowings.  (a)  Each Loan shall be made as
                         ---------------------                                 
part of a Borrowing consisting of Loans of the same Class and Type made by the
Lenders ratably in accordance with their respective Commitments of the
applicable Class.  The failure of any Lender to make any Loan required to be
made by it shall not relieve any other Lender of its obligations hereunder;
provided that the Commitments of the Lenders are several and no Lender shall be
- --------                                                                       
responsible for any other Lender's failure to make Loans as required.

          (b)  Subject to Section 2.13, each Revolving Borrowing and Term
Borrowing shall be comprised entirely of ABR Loans or Eurodollar Loans as the
Borrower may request for such Borrowing in accordance herewith.  Each Lender at
its option may make any Eurodollar Loan by causing any domestic or foreign
branch or Affiliate of such Lender to make such Loan; provided that (i) such
                                                      --------              
branch or Affiliate is subject to the provisions of Section 2.18, (ii) the
Borrower shall have no obligation under Section 2.14 or 2.16 to pay any amount
on account of any Lender causing any Loan to be made through any such branch or
Affiliate in excess of any such amount that the Borrower would have been
required to pay had such Lender made such Loan itself and (iii) any exercise of
such option shall not affect the obligation of the Borrower to repay such Loan
in accordance with the terms of this Agreement.

          (c)  At the commencement of each Interest Period for any Eurodollar
Borrowing, such Borrowing shall be in an aggregate amount that is an integral
multiple of $1,000,000 and not less than $5,000,000.  At the time that each ABR
Revolving Borrowing is made, such Borrowing shall be in an aggregate amount that
is an integral multiple of $1,000,000; provided that an ABR Revolving Borrowing
                                       --------                                
may be in an aggregate amount that is equal to the entire unused balance of the
total Revolving Commitments or that is required to finance the reimbursement of
an LC Disbursement as contemplated by Section 2.04(e).  Borrowings of more than
one Type and Class may be outstanding at the same time; provided that there
                                                        --------           
shall not at any time be more than a total of 15 Eurodollar Borrowings
outstanding.

          (d)  Notwithstanding any other provision of this Agreement, the
Borrower shall not be entitled to request, or to elect to convert or continue,
any Borrowing if the Interest Period requested with respect thereto would end
after the Maturity Date.

          SECTION 2.03.  Requests for Borrowings.  To request a Revolving
                         ------------------------                        
Borrowing, the Borrower shall notify the Administrative Agent of such request by
telephone (a) in the case of a Eurodollar Borrowing, not later than 11:00 a.m.,
New York City time, three Business Days before the date of the proposed
Borrowing or (b) in the case of an ABR Borrowing, not later than 10:00 a.m., New
York City time, on the date of the proposed Borrowing.  Each such telephonic
Borrowing Request shall be irrevocable and shall be confirmed promptly by hand
delivery or telecopy to the Administrative Agent of a written Borrowing Request
in a form approved by the Administrative Agent (which approval shall not be
unreasonably withheld) and signed by the Borrower.  Each such telephonic and
written Borrowing Request shall specify the following information in compliance
with Section 2.02:

          (i) the aggregate amount of such Borrowing;

          (ii) the date of such Borrowing, which shall be a Business Day;
<PAGE>
 
                                                                              26

          (iii) whether such Borrowing is to be an ABR Borrowing or a Eurodollar
     Borrowing;

          (iv) in the case of a Eurodollar Borrowing, the initial Interest
     Period to be applicable thereto, which shall be a period contemplated by
     the definition of the term "Interest Period"; and

          (v) the location and number of the Borrower's account to which funds
     are to be disbursed, which shall comply with the requirements of Section
     2.05.

If no election as to the Type of Borrowing is specified, then the requested
Borrowing shall be an ABR Borrowing.  If no Interest Period is specified with
respect to any requested Eurodollar Revolving Borrowing, then the Borrower shall
be deemed to have selected an Interest Period of one month's duration.  Promptly
following receipt of a Borrowing Request in accordance with this Section, the
Administrative Agent shall advise each Lender of the details thereof and of the
amount of such Lender's Loan to be made as part of the requested Borrowing.

          SECTION 2.04.  Letters of Credit.  (a)  General.  Subject to the terms
                         ------------------       --------                      
and conditions set forth herein, the Borrower may request the issuance of
Letters of Credit for its own account, in a form reasonably acceptable to the
Administrative Agent and the Issuing Bank, at any time and from time to time
during the LC Availability Period.  In the event of any inconsistency between
the terms and conditions of this Agreement and the terms and conditions of any
form of letter of credit application or other agreement submitted by the
Borrower to, or entered into by the Borrower with, the Issuing Bank relating to
any Letter of Credit, the terms and conditions of this Agreement shall control.

          (b)  Notice of Issuance, Amendment, Renewal, Extension; Certain
               ----------------------------------------------------------
Conditions.  To request the issuance of a Letter of Credit (or the amendment,
- -----------                                                                  
renewal or extension of an outstanding Letter of Credit), the Borrower shall
hand deliver or telecopy (or transmit by electronic communication, if
arrangements for doing so have been approved by the Issuing Bank) to the Issuing
Bank and the Administrative Agent (reasonably in advance of the requested date
of issuance, amendment, renewal or extension) a notice requesting the issuance
of a Letter of Credit, or identifying the Letter of Credit to be amended,
renewed or extended, and specifying the date of issuance, amendment, renewal or
extension (which shall be a Business Day), the date on which such Letter of
Credit is to expire (which shall comply with paragraph (c) of this Section), the
amount of such Letter of Credit, the name and address of the beneficiary thereof
and such other information as shall be necessary to prepare, amend, renew or
extend such Letter of Credit.  If requested by the Issuing Bank, the Borrower
also shall submit a letter of credit application on the Issuing Bank's standard
form in connection with any request for a Letter of Credit.  A Letter of Credit
shall be issued, amended, renewed or extended only if (and upon issuance,
amendment, renewal or extension of each Letter of Credit the Borrower shall be
deemed to represent and warrant that), after giving effect to such issuance,
amendment, renewal or extension (i) the LC Exposure shall not exceed $20,000,000
and (ii) the total Revolving Exposures shall not exceed the total Revolving
Commitments.

          (c)  Expiration Date.  Each Letter of Credit shall expire at or prior
               ----------------                                                
to the close of business on the earlier of (i) the date one year after the date
of the issuance of 
<PAGE>
 
                                                                              27

such Letter of Credit (or, in the case of any renewal or extension thereof, one
year after such renewal or extension) and (ii) the date that is five Business
Days prior to the Maturity Date; provided that any Letter of Credit issued in
                                 --------
respect of workmen's compensation obligations may provide for the automatic
renewal thereof for additional one-year periods (which shall in no event extend
beyond the date referred to in clause (ii) above) if the Issuing Bank does not
notify the beneficiary thereof that such Letter of Credit will not be extended.

          (d)  Participations.  By the issuance of a Letter of Credit (or an
               ---------------                                              
amendment to a Letter of Credit increasing the amount thereof) and without any
further action on the part of the Issuing Bank or the Lenders, the Issuing Bank
hereby grants to each Revolving Lender, and each Revolving Lender hereby
acquires from the Issuing Bank, a participation in such Letter of Credit equal
to such Lender's Applicable Percentage of the aggregate amount available to be
drawn under such Letter of Credit.  In consideration and in furtherance of the
foregoing, each Revolving Lender hereby absolutely and unconditionally agrees to
pay to the Administrative Agent, for the account of the Issuing Bank, such
Lender's Applicable Percentage of each LC Disbursement made by the Issuing Bank
and not reimbursed by the Borrower on the date due as provided in paragraph (e)
of this Section, or of any reimbursement payment required to be refunded to the
Borrower for any reason.  Each Lender acknowledges and agrees that its
obligation to acquire participations pursuant to this paragraph in respect of
Letters of Credit is absolute and unconditional and shall not be affected by any
circumstance whatsoever, including any amendment, renewal or extension of any
Letter of Credit or the occurrence and continuance of a Default or reduction or
termination of the Commitments, and that each such payment shall be made without
any offset, abatement, withholding or reduction whatsoever.

          (e)  Reimbursement.  If the Issuing Bank shall make any LC
               --------------                                       
Disbursement in respect of a Letter of Credit, the Borrower shall reimburse such
LC Disbursement by paying to the Administrative Agent an amount equal to such LC
Disbursement not later than 1:00 p.m., New York City time, on the date that such
LC Disbursement is made, if the Borrower shall have received notice of such LC
Disbursement prior to 10:00 a.m., New York City time, on such date, or, if such
notice has not been received by the Borrower prior to such time on such date,
then not later than 1:00 p.m., New York City time, on (i) the Business Day that
the Borrower receives such notice, if such notice is received prior to 10:00
a.m., New York City time, on the day of receipt, or (ii) the Business Day
immediately following the day that the Borrower receives such notice, if such
notice is not received prior to such time on the day of receipt; provided that
                                                                 --------     
the Borrower may, subject to the conditions to borrowing set forth herein,
request in accordance with Section 2.03 that such payment be financed with an
ABR Revolving Borrowing in an equivalent amount and, to the extent so financed,
the Borrower's obligation to make such payment shall be discharged and replaced
by the resulting ABR Revolving Borrowing.  If the Borrower fails to make such
payment when due, the Administrative Agent shall notify each Revolving Lender of
the applicable LC Disbursement, the payment then due from the Borrower in
respect thereof and such Lender's Applicable Percentage thereof.  Promptly
following receipt of such notice, each Revolving Lender shall pay to the
Administrative Agent its Applicable Percentage of the payment then due from the
Borrower, in the same manner as provided in Section 2.05 with respect to Loans
made by such Lender (and Section 2.05 shall apply, mutatis mutandis, to the
                                                   ------- --------        
payment obligations of the Revolving Lenders), and the Administrative 
<PAGE>
 
                                                                              28

Agent shall promptly pay to the Issuing Bank the amounts so received by it from
the Revolving Lenders. Promptly following receipt by the Administrative Agent of
any payment from the Borrower pursuant to this paragraph, the Administrative
Agent shall distribute such payment to the Issuing Bank or, to the extent that
Revolving Lenders have made payments pursuant to this paragraph to reimburse the
Issuing Bank, then to such Lenders and the Issuing Bank as their interests may
appear. Any payment made by a Revolving Lender pursuant to this paragraph to
reimburse the Issuing Bank for any LC Disbursement (other than the funding of
ABR Revolving Loans as contemplated above) shall not constitute a Loan and shall
not relieve the Borrower of its obligation to reimburse such LC Disbursement.

          (f)  Obligations Absolute.  The Borrower's obligation to reimburse LC
               ---------------------                                           
Disbursements as provided in paragraph (e) of this Section shall be absolute,
unconditional and irrevocable, and shall be performed strictly in accordance
with the terms of this Agreement under any and all circumstances whatsoever and
irrespective of (i) any lack of validity or enforceability of any Letter of
Credit or this Agreement, or any term or provision therein, (ii) any draft or
other document presented under a Letter of Credit proving to be forged,
fraudulent or invalid in any respect or any statement therein being untrue or
inaccurate in any respect, (iii) payment by the Issuing Bank under a Letter of
Credit against presentation of a draft or other document that does not comply
with the terms of such Letter of Credit, or (iv) any other event or circumstance
whatsoever, whether or not similar to any of the foregoing, that might, but for
the provisions of this Section, constitute a legal or equitable discharge of, or
provide a right of setoff against, the Borrower's obligations hereunder.
Neither the Administrative Agent, the Lenders nor the Issuing Bank, nor any of
their Related Parties, shall have any liability or responsibility by reason of
or in connection with the issuance or transfer of any Letter of Credit or any
payment or failure to make any payment thereunder (irrespective of any of the
circumstances referred to in the preceding sentence), or any error, omission,
interruption, loss or delay in transmission or delivery of any draft, notice or
other communication under or relating to any Letter of Credit (including any
document required to make a drawing thereunder), any error in interpretation of
technical terms or any consequence arising from causes beyond the control of the
Issuing Bank.  Notwithstanding the Borrower's obligation to reimburse LC
Disbursements, the foregoing shall not be construed to excuse the Issuing Bank
from liability to the Borrower to the extent of any direct damages (as opposed
to consequential damages, claims in respect of which are hereby waived by the
Borrower to the extent permitted by applicable law) suffered by the Borrower
that are caused by the Issuing Bank's failure to exercise care when determining
whether drafts and other documents presented under a Letter of Credit comply
with the terms thereof.  The parties hereto expressly agree that, in the absence
of gross negligence or wilful misconduct on the part of the Issuing Bank (as
finally determined by a court of competent jurisdiction), the Issuing Bank shall
be deemed to have exercised care in each such determination.  In furtherance of
the foregoing and without limiting the generality thereof, the parties agree
that, with respect to documents presented that appear on their face to be in
substantial compliance with the terms of a Letter of Credit, the Issuing Bank
may, in its sole discretion, either accept and make payment upon such documents
without responsibility for further investigation, regardless of any notice or
information to the contrary, or refuse to accept and make payment upon such
documents if such documents are not in strict compliance with the terms of such
Letter of Credit.
<PAGE>
 
                                                                              29

          (g)  Disbursement Procedures.  The Issuing Bank shall, promptly
               ------------------------                                  
following its receipt thereof, examine all documents purporting to represent a
demand for payment under a Letter of Credit.  The Issuing Bank shall promptly
notify the Administrative Agent and the Borrower by telephone (confirmed by
telecopy) of such demand for payment and whether the Issuing Bank has made or
will make an LC Disbursement thereunder; provided that any failure to give or
                                         --------                            
delay in giving such notice shall not relieve the Borrower of its obligation to
reimburse the Issuing Bank and the Revolving Lenders with respect to any such LC
Disbursement.

          (h)  Interim Interest.  If the Issuing Bank shall make any LC
               -----------------                                       
Disbursement, then, unless the Borrower shall reimburse such LC Disbursement in
full on the date such LC Disbursement is made, the unpaid amount thereof shall
bear interest, for each day from and including the date such LC Disbursement is
made to but excluding the date that the Borrower reimburses such LC
Disbursement, at the rate per annum then applicable to ABR Revolving Loans;
provided that, if the Borrower fails to reimburse such LC Disbursement when due
- --------                                                                       
pursuant to paragraph (e) of this Section, then Section 2.12(c) shall apply.
Interest accrued pursuant to this paragraph shall be for the account of the
Issuing Bank, except that interest accrued on and after the date of payment by
any Revolving Lender pursuant to paragraph (e) of this Section to reimburse the
Issuing Bank shall be for the account of such Lender to the extent of such
payment.

          (i)  Replacement of the Issuing Bank.  The Issuing Bank may be
               --------------------------------                         
replaced at any time by written agreement among the Borrower, the Administrative
Agent, the replaced Issuing Bank and the successor Issuing Bank.  The
Administrative Agent shall notify the Lenders of any such replacement of the
Issuing Bank.  At the time any such replacement shall become effective, the
Borrower shall pay all unpaid fees accrued for the account of the replaced
Issuing Bank pursuant to Section 2.11(b).  From and after the effective date of
any such replacement, (i) the successor Issuing Bank shall have all the rights
and obligations of the Issuing Bank under this Agreement with respect to Letters
of Credit to be issued thereafter and (ii) references herein to the term
"Issuing Bank" shall be deemed to refer to such successor or to any previous
Issuing Bank, or to such successor and all previous Issuing Banks, as the
context shall require.  After the replacement of an Issuing Bank hereunder, the
replaced Issuing Bank shall remain a party hereto and shall continue to have all
the rights and obligations of an Issuing Bank under this Agreement with respect
to Letters of Credit issued by it prior to such replacement, but shall not be
required to issue additional Letters of Credit.

          (j)  Cash Collateralization.  If any Event of Default shall occur and
               -----------------------                                         
be continuing, on the Business Day that the Borrower receives notice from the
Administrative Agent or the Required Lenders (or, if the maturity of the Loans
has been accelerated, Revolving Lenders with LC Exposure representing greater
than 50% of the total LC Exposure) demanding the deposit of cash collateral
pursuant to this paragraph, the Borrower shall deposit in an account with the
Administrative Agent, in the name of the Administrative Agent and for the
benefit of the Lenders, an amount in cash equal to the LC Exposure as of such
date plus any accrued and unpaid interest thereon; provided that the obligation
                                                   --------                    
to deposit such cash collateral shall become effective immediately, and such
deposit shall become immediately due and payable, without demand or other notice
of any kind, upon the occurrence of any Event of Default with respect to the
Borrower described in clause (i) or (j) of Article VII.  Each such deposit shall
be held by the Administrative Agent as collateral for the payment and
performance of the obligations of 
<PAGE>
 
                                                                              30

the Borrower under this Agreement. The Administrative Agent shall have exclusive
dominion and control, including the exclusive right of withdrawal, over such
account. Other than any interest earned on the investment of such deposits,
which investments shall be made at the option and sole discretion of the
Administrative Agent and at the Borrower's risk and expense, such deposits shall
not bear interest. Interest or profits, if any, on such investments shall
accumulate in such account. Moneys in such account shall be applied by the
Administrative Agent to reimburse the Issuing Bank for LC Disbursements for
which it has not been reimbursed and, to the extent not so applied, shall be
held for the satisfaction of the reimbursement obligations of the Borrower for
the LC Exposure at such time or, if the maturity of the Loans has been
accelerated (but subject to the consent of Revolving Lenders with LC Exposure
representing greater than 50% of the total LC Exposure), be applied to satisfy
other obligations of the Borrower under this Agreement. If the Borrower is
required to provide an amount of cash collateral hereunder as a result of the
occurrence of an Event of Default, such amount (to the extent not applied as
aforesaid) shall be returned to the Borrower within three Business Days after
all Events of Default have been cured or waived.

          SECTION 2.05.  Funding of Borrowings.  (a)  Each Lender shall make
                         ----------------------                             
each Loan to be made by it hereunder on the proposed date thereof by wire
transfer of immediately available funds by 12:00 noon, New York City time, to
the account of the Administrative Agent most recently designated by the
Administrative Agent for such purpose by notice to the Lenders.  The
Administrative Agent will make such Loans available to the Borrower by promptly
crediting the amounts so received, in like funds, to an account of the Borrower
maintained with the Administrative Agent in New York City and designated by the
Borrower in the applicable Borrowing Request on or before the close of business
on the proposed date of the Borrowing; provided that ABR Revolving Loans made to
                                       --------                                 
finance the reimbursement of an LC Disbursement as provided in Section 2.04(e)
shall be remitted by the Administrative Agent to the Issuing Bank.

          (b)  Unless the Administrative Agent shall have received notice from a
Lender prior to the proposed date of any Borrowing that such Lender will not
make available to the Administrative Agent such Lender's share of such
Borrowing, the Administrative Agent may assume that such Lender has made such
share available on such date in accordance with paragraph (a) of this Section
and may, in reliance upon such assumption, make available to the Borrower a
corresponding amount.  In such event, if a Lender has not in fact made its share
of the applicable Borrowing available to the Administrative Agent, then such
amount shall not be deemed a Loan under this Agreement and the applicable Lender
and the Borrower severally agree to pay to the Administrative Agent forthwith on
demand such corresponding amount with interest thereon, for each day from and
including the date such amount is made available to the Borrower to but
excluding the date of payment to the Administrative Agent, at (i) in the case of
such Lender, the greater of the Federal Funds Effective Rate and a rate
determined by the Administrative Agent in accordance with banking industry rules
on interbank compensation or (ii) in the case of the Borrower, the interest rate
applicable to ABR Loans.  If such Lender pays such amount to the Administrative
Agent, then such amount shall constitute such Lender's Loan included in such
Borrowing.

          SECTION 2.06.  Interest Elections.  (a)  Each Revolving Borrowing and
                         -------------------                                   
Term Borrowing initially shall be of the Type specified in the applicable
Borrowing Request and, in the case of a Eurodollar Borrowing, shall have an
initial Interest Period as 
<PAGE>
 
                                                                              31

specified in such Borrowing Request. Thereafter, the Borrower may elect to
convert such Borrowing to a different Type or to continue such Borrowing and, in
the case of a Eurodollar Borrowing, may elect Interest Periods therefor, all as
provided in this Section. The Borrower may elect different options with respect
to different portions of the affected Borrowing, in which case each such portion
shall be allocated ratably among the Lenders holding the Loans comprising such
Borrowing, and the Loans comprising each such portion shall be considered a
separate Borrowing.

          (b)  To make an election pursuant to this Section, the Borrower shall
notify the Administrative Agent of such election by telephone by the time that a
Borrowing Request would be required under Section 2.03 if the Borrower were
requesting a Revolving Borrowing of the Type resulting from such election to be
made on the effective date of such election.  Each such telephonic Interest
Election Request shall be irrevocable and shall be confirmed promptly by hand
delivery or telecopy to the Administrative Agent of a written Interest Election
Request in a form approved by the Administrative Agent and signed by the
Borrower.

          (c)  Each telephonic and written Interest Election Request shall
specify the following information in compliance with Section 2.02 and paragraph
(f) of this Section:

          (i) the Borrowing to which such Interest Election Request applies and,
     if different options are being elected with respect to different portions
     thereof, the portions thereof to be allocated to each resulting Borrowing
     (in which case the information to be specified pursuant to clauses (iii)
     and (iv) below shall be specified for each resulting Borrowing);

          (ii) the effective date of the election made pursuant to such Interest
     Election Request, which shall be a Business Day;

          (iii) whether the resulting Borrowing is to be an ABR Borrowing or a
     Eurodollar Borrowing; and

          (iv) if the resulting Borrowing is a Eurodollar Borrowing, the
     Interest Period to be applicable thereto after giving effect to such
     election, which shall be a period contemplated by the definition of the
     term "Interest Period".

If any such Interest Election Request requests a Eurodollar Borrowing but does
not specify an Interest Period, then the Borrower shall be deemed to have
selected an Interest Period of one month's duration.

          (d)  Promptly following receipt of an Interest Election Request, the
Administrative Agent shall advise each Lender of the details thereof and of such
Lender's portion of each resulting Borrowing.

          (e)  If the Borrower fails to deliver a timely Interest Election
Request with respect to a Eurodollar Borrowing prior to the end of the Interest
Period applicable thereto, then, unless such Borrowing is repaid as provided
herein, at the end of such Interest Period such Borrowing shall be converted to
an ABR Borrowing. Notwithstanding any contrary provision hereof, if an Event of
Default has occurred and is continuing and the Administrative Agent, at the
request of the Required Lenders, so 
<PAGE>
 
                                                                              32

notifies the Borrower, then, so long as an Event of Default is continuing (i) no
outstanding Borrowing may be converted to or continued as a Eurodollar Borrowing
and (ii) unless repaid, each Eurodollar Borrowing shall be converted to an ABR
Borrowing at the end of the Interest Period applicable thereto.

          (f)  A Borrowing of any Class may not be converted to or continued as
a Eurodollar Borrowing if after giving effect thereto (i) the Interest Period
therefor would commence before and end after a date on which any principal of
the Loans of such Class is scheduled to be repaid and (ii) the sum of the
aggregate principal amount of outstanding Eurodollar Borrowings of such Class
with Interest Periods ending on or prior to such scheduled repayment date plus
the aggregate principal amount of outstanding ABR Borrowings of such Class would
be less than the aggregate principal amount of Loans of such Class required to
be repaid on such scheduled repayment date.

          SECTION 2.07.  Termination and Reduction of Commitments.  (a)  The
                         -----------------------------------------          
Term Commitments terminated at 5:00 p.m., New York City time, on the Effective
Date. Unless previously terminated, the Revolving Commitments shall terminate on
the Maturity Date.

          (b)  The Borrower may at any time terminate, or from time to time
reduce, the Commitments of any Class; provided that (i) each reduction of the
                                      --------                               
Commitments of any Class shall be in an amount that is an integral multiple of
$500,000 and not less than $1,000,000 and (ii) the Borrower shall not terminate
or reduce the Revolving Commitments if, after giving effect to any concurrent
prepayment of the Revolving Loans in accordance with Section 2.10, the sum of
the Revolving Exposures would exceed the total Revolving Commitments.

          (c)  The Borrower shall notify the Administrative Agent of any
election to terminate or reduce the Commitments under paragraph (b) of this
Section at least three Business Days prior to the effective date of such
termination or reduction, specifying such election and the effective date
thereof.  Promptly following receipt of any such notice, the Administrative
Agent shall advise the Lenders of the contents thereof.  Each notice delivered
by the Borrower pursuant to this Section shall be irrevocable; provided that a
                                                               --------       
notice of termination of the Revolving Commitments delivered by the Borrower may
state that such notice is conditioned upon the effectiveness of other credit
facilities, in which case such notice may be revoked by the Borrower (by notice
to the Administrative Agent on or prior to the specified effective date) if such
condition is not satisfied.  Any termination or reduction of the Commitments of
any Class shall be permanent.  Each reduction of the Commitments of any Class
shall be made ratably among the Lenders in accordance with their respective
Commitments of such Class.

          SECTION 2.08.  Repayment of Loans; Evidence of Debt.  (a)  The
                         -------------------------------------          
Borrower hereby unconditionally promises to pay (i) to the Administrative Agent
for the account of each Lender the then unpaid principal amount of each
Revolving Loan of such Lender on the Maturity Date and (ii) to the
Administrative Agent for the account of each Lender the then unpaid principal
amount of each Term Loan of such Lender as provided in Section 2.09.

          (b)  Each Lender shall maintain in accordance with its usual practice
an account or accounts evidencing the indebtedness of the Borrower to such
Lender resulting 
<PAGE>
 
                                                                              33

from each Loan made by such Lender, including the amounts of principal and
interest payable and paid to such Lender from time to time hereunder.

          (c)  The Administrative Agent shall maintain accounts in which it
shall record (i) the amount of each Loan made hereunder, the Class and Type
thereof and the Interest Period applicable thereto, (ii) the amount of any
principal or interest due and payable or to become due and payable from the
Borrower to each Lender hereunder and (iii) the amount of any sum received by
the Administrative Agent hereunder for the account of the Lenders and each
Lender's share thereof.

          (d)  The entries made in the accounts maintained pursuant to paragraph
(b) or (c) of this Section shall be prima facie evidence of the existence and
                                    ----- -----                              
amounts of the obligations recorded therein; provided that the failure of any
                                             --------                        
Lender or the Administrative Agent to maintain such accounts or any error
therein shall not in any manner affect the obligation of the Borrower to repay
the Loans in accordance with the terms of this Agreement.

          (e)  Any Lender may request that Loans of any Class made by it be
evidenced by a promissory note.  In such event, the Borrower shall prepare,
execute and deliver to such Lender a promissory note payable to the order of
such Lender (or, if requested by such Lender, to such Lender and its registered
assigns) in accordance with the terms of this Agreement and in a form approved
by the Administrative Agent. Thereafter, the Loans evidenced by such promissory
note and interest thereon shall at all times (including after assignment
pursuant to Section 9.04) be represented by one or more promissory notes in such
form payable to the order of the payee named therein (or, if such promissory
note is a registered note, to such payee and its registered assigns).

          SECTION 2.09.  Amortization of Term Loans.  (a)  Subject to adjustment
                         ---------------------------                            
pursuant to paragraph (c) of this Section, the Borrower shall repay Term
Borrowings on each date set forth below in the aggregate principal amount set
forth opposite such date:
 
           Date                 Amount
           ----                 ------
 
     December 31, 1999     $10,000,000.00
     March 31, 2000        $ 3,750,000.00
     June 30, 2000         $ 3,750,000.00
     September 30, 2000    $ 3,750,000.00
     December 31, 2000     $ 3,750,000.00
     March 31, 2001        $ 5,000,000.00
     June 30, 2001         $ 5,000,000.00
     September 30, 2001    $ 5,000,000.00
     December 31, 2001     $ 5,000,000.00
     March 31, 2002        $ 7,500,000.00
     June 30, 2002         $ 7,500,000.00
     September 30, 2002    $ 7,500,000.00
     December 31, 2002     $ 7,500,000.00

          (b)  To the extent not previously paid, all Term Loans shall be due
and payable on the Maturity Date.
<PAGE>
 
                                                                              34

          (c)  Any prepayment of a Term Borrowing shall be applied to reduce the
subsequent scheduled repayments of the Term Borrowings to be made pursuant to
this Section ratably; provided that any prepayment made pursuant to Section
                      --------                                             
2.10(a) shall be applied, first, to reduce the next two scheduled repayments of
the Term Borrowings to be made pursuant to this Section in order of maturity (to
the extent that such scheduled repayments would otherwise occur within 12 months
of such prepayment made pursuant to Section 2.10(a)) unless and until such next
two scheduled repayments have been eliminated as a result of reductions
hereunder and, second, to reduce the remaining scheduled repayments of the Term
Borrowings to be made pursuant to this Section ratably.

          (d)  Prior to any repayment of any Term Borrowings hereunder, the
Borrower shall select the Borrowing or Borrowings to be repaid and shall notify
the Administrative Agent by telephone (confirmed by telecopy) of such selection
not later than 11:00 a.m., New York City time, three Business Days before the
scheduled date of such repayment; provided that each repayment of Term
                                  --------                            
Borrowings shall be applied to repay any outstanding ABR Term Borrowings before
any other Borrowings. Each repayment of a Borrowing shall be applied ratably to
the Loans included in the repaid Borrowing.  Repayments of Term Borrowings shall
be accompanied by accrued interest on the amount repaid.

          SECTION 2.10.  Prepayment of Loans.  (a)  The Borrower shall have the
                         --------------------                                  
right at any time and from time to time to prepay any Borrowing in whole or in
part, subject to the requirements of this Section.

          (b)  In the event and on each occasion that any Net Proceeds are
received by or on behalf of Catalytica, the Borrower or any Restricted
Subsidiary in respect of any Prepayment Event, the Borrower shall, within three
Business Days after such Net Proceeds are received, prepay Term Borrowings in an
aggregate amount equal to such Net Proceeds.

          (c)  Prior to any optional or mandatory prepayment of Borrowings
hereunder, the Borrower shall select the Borrowing or Borrowings to be prepaid
and shall specify such selection in the notice of such prepayment pursuant to
paragraph (d) of this Section; provided that each prepayment of Borrowings of
                               --------                                      
any Class shall be applied to prepay ABR Borrowings of such Class before any
other Borrowings of such Class.

          (d)  The Borrower shall notify the Administrative Agent by telephone
(confirmed by telecopy) of any prepayment hereunder (i) in the case of
prepayment of a Eurodollar Borrowing, not later than 11:00 a.m., New York City
time, three Business Days before the date of prepayment or (ii) in the case of
prepayment of an ABR Borrowing, not later than 10:00 a.m., New York City time,
on the date of prepayment. Each such notice shall be irrevocable and shall
specify the prepayment date, the principal amount of each Borrowing or portion
thereof to be prepaid and, in the case of a mandatory prepayment, a reasonably
detailed calculation of the amount of such prepayment; provided that, if a
                                                       --------           
notice of optional prepayment is given in connection with a conditional notice
of termination of the Revolving Commitments as contemplated by Section 2.07,
then such notice of prepayment may be revoked if such notice of termination is
revoked in accordance with Section 2.07.  Promptly following receipt of any such
notice, the Administrative Agent shall advise the Lenders of the contents
<PAGE>
 
                                                                              35

thereof.  Each partial prepayment of any Borrowing shall be in an amount that
would be permitted in the case of an advance of a Borrowing of the same Type as
provided in Section 2.02(c), except as necessary to apply fully the required
amount of a mandatory prepayment.  Each prepayment of a Borrowing shall be
applied ratably to the Loans included in the prepaid Borrowing.  Prepayments
shall be accompanied by accrued interest to the extent required by Section 2.12.

          SECTION 2.11.  Fees.  (a)  The Borrower agrees to pay to the
                         -----                                        
Administrative Agent for the account of each Lender a commitment fee, which
shall accrue at the Applicable Rate on the average daily unused amount of the
Revolving Commitment of such Lender during the period from and including the
Effective Date to but excluding the date on which such Commitment terminates.
Accrued commitment fees shall be payable in arrears on the last Business Day of
March, June, September and December of each year and on the date on which the
Revolving Commitments terminate, commencing on the first such date to occur
after the date hereof.  All commitment fees shall be computed on the basis of a
year of 360 days and shall be payable for the actual number of days elapsed
(including the first day but excluding the last day).  For purposes of computing
commitment fees with respect to Revolving Commitments, a Revolving Commitment of
a Lender shall be deemed to be used to the extent of the outstanding Revolving
Loans and LC Exposure of such Lender.

          (b)  The Borrower agrees to pay (i) to the Administrative Agent for
the account of each Revolving Lender a participation fee with respect to its
participations in Letters of Credit, which shall accrue at the same Applicable
Rate as interest on Eurodollar Revolving Loans on the average daily amount of
such Lender's LC Exposure (excluding any portion thereof attributable to
unreimbursed LC Disbursements) during the period from and including the
Effective Date to but excluding the later of the date on which such Lender's
Revolving Commitment terminates and the date on which such Lender ceases to have
any LC Exposure, and (ii) to the Issuing Bank a fronting fee, which shall accrue
at the rate of 1/4 of 1% per annum on the average daily amount of the LC
Exposure (excluding any portion thereof attributable to unreimbursed LC
Disbursements) during the period from and including the Effective Date to but
excluding the later of the date of termination of the Revolving Commitments and
the date on which there ceases to be any LC Exposure, as well as the Issuing
Bank's standard fees with respect to the issuance, amendment, renewal or
extension of any Letter of Credit or processing of drawings thereunder.
Participation fees and fronting fees accrued through and including the last
Business Day of March, June, September and December of each year shall be
payable on the third Business Day following such last day, commencing on the
first such date to occur after the Effective Date; provided that all such fees
                                                   --------                   
shall be payable on the date on which the Revolving Commitments terminate and
any such fees accruing after the date on which the Revolving Commitments
terminate shall be payable on demand.  Any other fees payable to the Issuing
Bank pursuant to this paragraph shall be payable within 10 days after demand.
All participation fees and fronting fees shall be computed on the basis of a
year of 360 days and shall be payable for the actual number of days elapsed
(including the first day but excluding the last day).

          (c)  The Borrower agrees to pay to the Administrative Agent, for its
own account, fees payable in the amounts and at the times separately agreed upon
between the Borrower and the Administrative Agent.
<PAGE>
 
                                                                              36

          (d)  All fees payable hereunder shall be paid on the dates due, in
immediately available funds, to the Administrative Agent (or to the Issuing
Bank, in the case of fees payable to it) for prompt distribution, in the case of
commitment fees and participation fees, to the Lenders entitled thereto.  Fees
paid shall not be refundable under any circumstances other than manifest error.

          SECTION 2.12.  Interest.  (a)  The Loans comprising each ABR Borrowing
                         ---------                                              
shall bear interest at the Alternate Base Rate plus the Applicable Rate.

          (b)  The Loans comprising each Eurodollar Borrowing shall bear
interest at the Adjusted LIBO Rate for the Interest Period in effect for such
Borrowing plus the Applicable Rate.

          (c)  Notwithstanding the foregoing, if any principal of or interest on
any Loan or any fee or other amount payable by the Borrower hereunder is not
paid when due, whether at stated maturity, upon acceleration or otherwise, such
overdue amount shall bear interest, after as well as before judgment, at a rate
per annum equal to (i) in the case of overdue principal of any Loan, 2% plus the
rate otherwise applicable to such Loan as provided in the preceding paragraphs
of this Section or (ii) in the case of any other amount, 2% plus the rate
applicable to ABR Revolving Loans as provided in paragraph (a) of this Section.

          (d)  Accrued interest on each Loan shall be payable in arrears on each
Interest Payment Date for such Loan and, in the case of Revolving Loans, upon
termination of the Revolving Commitments; provided that (i) interest accrued
                                          --------                          
pursuant to paragraph (c) of this Section shall be payable on demand, (ii) in
the event of any repayment or prepayment of any Loan (other than a prepayment of
an ABR Revolving Loan prior to the end of the Revolving Availability Period),
accrued interest on the principal amount repaid or prepaid shall be payable on
the date of such repayment or prepayment and (iii) in the event of any
conversion of any Eurodollar Loan prior to the end of the current Interest
Period therefor, accrued interest on such Loan shall be payable on the effective
date of such conversion.

          (e)  All interest hereunder shall be computed on the basis of a year
of 360 days, except that interest computed by reference to the Alternate Base
Rate at times when the Alternate Base Rate is based on the Prime Rate shall be
computed on the basis of a year of 365 days (or 366 days in a leap year), and in
each case shall be payable for the actual number of days elapsed (including the
first day but excluding the last day).  The applicable Alternate Base Rate or
Adjusted LIBO Rate shall be determined by the Administrative Agent, and such
determination shall be conclusive absent manifest error.

          SECTION 2.13.  Alternate Rate of Interest.  If prior to the
                         ---------------------------                 
commencement of any Interest Period for a Eurodollar Borrowing:

          (a) the Administrative Agent determines (which determination shall be
     conclusive absent manifest error) that adequate and reasonable means do not
     exist for ascertaining the Adjusted LIBO Rate for such Interest Period; or

          (b) the Administrative Agent is advised by the Required Lenders that
     the Adjusted LIBO Rate for such Interest Period will not adequately and
     fairly reflect 
<PAGE>
 
                                                                              37

     the cost to such Lenders (or Lender) of making or maintaining their Loans
     (or its Loan) included in such Borrowing for such Interest Period;

then the Administrative Agent shall give notice thereof to the Borrower and the
Lenders by telephone or telecopy as promptly as practicable thereafter and,
until the Administrative Agent notifies the Borrower and the Lenders that the
circumstances giving rise to such notice no longer exist, (i) any Interest
Election Request that requests the conversion of any Borrowing to, or
continuation of any Borrowing as, a Eurodollar Borrowing shall be ineffective
and (ii) if any Borrowing Request requests a Eurodollar Borrowing, such
Borrowing shall be made as an ABR Borrowing.

          SECTION 2.14.  Increased Costs.  (a)  If any Change in Law shall:
                         ----------------                                  

          (i) impose, modify or deem applicable any reserve, special deposit or
     similar requirement against assets of, deposits with or for the account of,
     or credit extended by, any Lender (except any such reserve requirement
     reflected in the Adjusted LIBO Rate) or the Issuing Bank; or

          (ii) impose on any Lender or the Issuing Bank or the London interbank
     market any other condition (other than imposition of Taxes) affecting this
     Agreement or Eurodollar Loans made by such Lender or any Letter of Credit
     or participation therein;

and the result of any of the foregoing shall be to increase the cost to such
Lender of making or maintaining any Eurodollar Loan (or of maintaining its
obligation to make any such Loan) or to increase the cost to such Lender or the
Issuing Bank of participating in, issuing or maintaining any Letter of Credit or
to reduce the amount of any sum received or receivable by such Lender or the
Issuing Bank hereunder (whether of principal, interest or otherwise), then the
Borrower will pay to such Lender or the Issuing Bank, as the case may be, such
additional amount or amounts as will compensate such Lender or the Issuing Bank,
as the case may be, for such additional costs incurred or reduction suffered.

          (b)  If any Lender or the Issuing Bank determines that any Change in
Law regarding capital requirements has or would have the effect of reducing the
rate of return on such Lender's or the Issuing Bank's capital or on the capital
of such Lender's or the Issuing Bank's holding company, if any, as a consequence
of this Agreement or the Loans made by, or participations in Letters of Credit
held by, such Lender, or the Letters of Credit issued by the Issuing Bank, to a
level below that which such Lender or the Issuing Bank or such Lender's or the
Issuing Bank's holding company could have achieved but for such Change in Law
(taking into consideration such Lender's or the Issuing Bank's policies and the
policies of such Lender's or the Issuing Bank's holding company with respect to
capital adequacy), then from time to time the Borrower will pay to such Lender
or the Issuing Bank, as the case may be, such additional amount or amounts as
will compensate such Lender or the Issuing Bank or such Lender's or the Issuing
Bank's holding company for any such reduction suffered.

          (c)  A certificate of a Lender or the Issuing Bank setting forth the
amount or amounts necessary to compensate such Lender or the Issuing Bank or its
holding company, as the case may be, as specified in paragraph (a) or (b) of
this Section shall be delivered to the Borrower and shall be conclusive absent
manifest error.  The Borrower 
<PAGE>
 
                                                                              38

shall pay such Lender or the Issuing Bank, as the case may be, the amount shown
as due on any such certificate (absent manifest error) within 10 days after
receipt thereof.

          (d)  Failure or delay on the part of any Lender or the Issuing Bank to
demand compensation pursuant to this Section shall not constitute a waiver of
such Lender's or the Issuing Bank's right to demand such compensation; provided
                                                                       --------
that the Borrower shall not be required to compensate a Lender or the Issuing
Bank pursuant to this Section for any increased costs or reductions incurred
more than 180 days prior to the date that such Lender or the Issuing Bank, as
the case may be, notifies the Borrower of the Change in Law giving rise to such
increased costs or reductions and of such Lender's or the Issuing Bank's
intention to claim compensation therefor; provided further that, if the Change
                                          ----------------                    
in Law giving rise to such increased costs or reductions is retroactive, then
the 180-day period referred to above shall be extended to include the period of
retroactive effect thereof.

          SECTION 2.15.  Break Funding Payments.  In the event of (a) the
                         -----------------------                         
payment of any principal of any Eurodollar Loan other than on the last day of an
Interest Period applicable thereto (including as a result of an Event of
Default), (b) the conversion of any Eurodollar Loan other than on the last day
of the Interest Period applicable thereto, (c) the failure to borrow, convert,
continue or prepay any Revolving Loan or Term Loan on the date specified in any
notice delivered pursuant hereto (regardless of whether such notice may be
revoked under Section 2.10(d) and is revoked in accordance therewith), or (d)
the assignment of any Eurodollar Loan other than on the last day of the Interest
Period applicable thereto as a result of a request by the Borrower pursuant to
Section 2.18, then, in any such event, the Borrower shall compensate each Lender
for the loss, cost and expense attributable to such event.  In the case of a
Eurodollar Loan, such loss, cost or expense to any Lender shall be deemed to
include an amount determined by such Lender to be the excess, if any, of (i) the
amount of interest that would have accrued on the principal amount of such Loan
had such event not occurred, at the Adjusted LIBO Rate that would have been
applicable to such Loan, for the period from the date of such event to the last
day of the then current Interest Period therefor (or, in the case of a failure
to borrow, convert or continue, for the period that would have been the Interest
Period for such Loan), over (ii) the amount of interest that would accrue on
such principal amount for such period at the interest rate that such Lender
would bid were it to bid, at the commencement of such period, for dollar
deposits of a comparable amount and period from other banks in the Eurodollar
market.  A certificate of any Lender setting forth any amount or amounts that
such Lender is entitled to receive pursuant to this Section shall be delivered
to the Borrower and shall be conclusive absent manifest error.  The Borrower
shall pay such Lender the amount shown as due on any such certificate (absent
manifest error) within 10 days after receipt thereof.

          SECTION 2.16.  Taxes.  (a)  Any and all payments by or on account of
                         ------                                               
any obligation of the Borrower hereunder or under any other Loan Document shall
be made free and clear of and without deduction for any Indemnified Taxes or
Other Taxes; provided that if the Borrower shall be required to deduct any
             --------                                                     
Indemnified Taxes or Other Taxes from such payments, then, to the extent
permitted by law, (i) the sum payable shall be increased as necessary so that
after making all required deductions (including deductions applicable to
additional sums payable under this Section) the Administrative Agent, Lender or
Issuing Bank (as the case may be) receives an amount equal to the sum it would
have received had no such deductions been made, (ii) the Borrower shall make
<PAGE>
 
                                                                              39

such deductions and (iii) the Borrower shall pay the full amount deducted to the
relevant Governmental Authority in accordance with applicable law.

          (b)  In addition, the Borrower shall pay any Other Taxes to the
relevant Governmental Authority in accordance with applicable law.

          (c)  The Borrower shall indemnify the Administrative Agent, each
Lender and the Issuing Bank, within 10 days after written demand therefor, for
the full amount of any Indemnified Taxes or Other Taxes paid by the
Administrative Agent, such Lender or the Issuing Bank, as the case may be, on or
with respect to any payment by or on account of any obligation of the Borrower
hereunder or under any other Loan Document (including Indemnified Taxes or Other
Taxes imposed or asserted on or attributable to amounts payable under this
Section) and any penalties, interest and reasonable expenses arising therefrom
or with respect thereto from causes other than the breach of the Loan Documents
or the gross negligence of the party demanding reimbursement, whether or not
such Indemnified Taxes or Other Taxes were correctly or legally imposed or
asserted by the relevant Governmental Authority.  A certificate as to the amount
of such payment or liability delivered to the Borrower by a Lender or the
Issuing Bank, or by the Administrative Agent on its own behalf or on behalf of a
Lender or the Issuing Bank, shall be conclusive absent manifest error.

          (d)  If any Indemnified Taxes or Other Taxes are incorrectly or
illegally imposed or asserted, the Borrower and Lender agree to reasonably
cooperate to contest such Taxes.

          (e)  As soon as practicable after any payment of Indemnified Taxes or
Other Taxes by the Borrower to a Governmental Authority, the Borrower shall
deliver to the Administrative Agent the original or a certified copy of a
receipt issued by such Governmental Authority evidencing such payment, a copy of
the return reporting such payment or other evidence of such payment reasonably
satisfactory to the Administrative Agent.

          (f)  Any Foreign Lender that is entitled to an exemption from or
reduction of withholding tax under the law of the jurisdiction in which the
Borrower is located, or any treaty to which such jurisdiction is a party, with
respect to payments under this Agreement shall deliver to the Borrower (with a
copy to the Administrative Agent), at the time or times prescribed by applicable
law after receipt of written notice from the Borrower, such properly completed
and executed documentation prescribed by applicable law or reasonably requested
by the Borrower as will permit such payments to be made without withholding or
at a reduced rate.

          (g)  If the Administrative Agent or Lender (or Transferee) receives a
refund solely in respect of Taxes or Other Taxes, it shall pay over such refund
to the Borrower to the extent that it has already received indemnity payments or
additional amounts pursuant to this Section 2.16 with respect to such Taxes or
Other Taxes giving rise to the refund, net of all out-of-pocket expenses and
without interest (other than interest paid by the relevant Governmental
Authority with respect to such refund); provided, however, that the Borrower
                                        --------  -------                   
shall, upon request of the Administrative Agent or Lender (or Transferee), repay
such refund (plus penalties, interest or other charges imposed by the relevant
Governmental Authority) to the Administrative Agent or Lender 
<PAGE>
 
                                                                              40

(or Transferee) if the Administrative Agent or Lender (or Transferee) is
required to repay such refund to such Governmental Authority. Nothing contained
herein shall require the Administrative Agent or Lender (or Transferee) to make
its tax returns (or any other information relating to its taxes which it deems
confidential) available to the Borrower or any other person.

          SECTION 2.17.  Payments Generally; Pro Rata Treatment; Sharing of
                         --------------------------------------------------
Setoffs.  (a)  The Borrower shall make each payment required to be made by it
- --------                                                                     
hereunder or under any other Loan Document (whether of principal, interest, fees
or reimbursement of LC Disbursements, or of amounts payable under Section 2.14,
2.15 or 2.16, or otherwise) prior to 1:00 p.m., New York City time, on the date
when due, in immediately available funds, without set-off or counterclaim.  Any
amounts received after such time on any date may, in the discretion of the
Administrative Agent, be deemed to have been received on the next succeeding
Business Day for purposes of calculating interest thereon.  All such payments
shall be made to the Administrative Agent c/o The Loan and Agency Services Group
at its offices at One Chase Manhattan Plaza, 8th Floor, New York, New York,
10081, except payments to be made directly to the Issuing Bank as expressly
provided herein and except that payments pursuant to Sections 2.14, 2.15, 2.16
and 9.03 shall be made directly to the Persons entitled thereto and payments
pursuant to other Loan Documents shall be made to the Persons specified therein.
The Administrative Agent shall distribute promptly any such payments received by
it for the account of any other Person to the appropriate recipient promptly
following receipt thereof.  If any payment under any Loan Document shall be due
on a day that is not a Business Day, the date for payment shall be extended to
the next succeeding Business Day, and, in the case of any payment accruing
interest, interest thereon shall be payable for the period of such extension.
All payments under each Loan Document shall be made in dollars.

          (b)  If at any time insufficient funds are received by and available
to the Administrative Agent to pay fully all amounts of principal, unreimbursed
LC Disbursements, interest and fees then due hereunder, such funds shall be
applied (i) first, towards payment of interest and fees then due hereunder,
ratably among the parties entitled thereto in accordance with the amounts of
interest and fees then due to such parties, and (ii) second, towards payment of
principal and unreimbursed LC Disbursements then due hereunder, ratably among
the parties entitled thereto in accordance with the amounts of principal and
unreimbursed LC Disbursements then due to such parties.

          (c)  If any Lender shall, by exercising any right of set-off or
counterclaim or otherwise, obtain payment in respect of any principal of or
interest on any of its Revolving Loans, Term Loans or participations in LC
Disbursements resulting in such Lender receiving payment of a greater proportion
of the aggregate amount of its Revolving Loans, Term Loans and participations in
LC Disbursements and accrued interest thereon than the proportion received by
any other Lender, then the Lender receiving such greater proportion shall
purchase (for cash at face value) participations in the Revolving Loans, Term
Loans and participations in LC Disbursements of other Lenders to the extent
necessary so that the benefit of all such payments shall be shared by the
Lenders ratably in accordance with the aggregate amount of principal of and
accrued interest on their respective Revolving Loans, Term Loans and
participations in LC Disbursements; provided that (i) if any such participations
                                    --------                                    
are purchased and all or 
<PAGE>
 
                                                                              41

any portion of the payment giving rise thereto is recovered, such participations
shall be rescinded and the purchase price restored to the extent of such
recovery, without interest, and (ii) the provisions of this paragraph shall not
be construed to apply to any payment made by the Borrower pursuant to and in
accordance with the express terms of this Agreement or any payment obtained by a
Lender as consideration for the assignment of or sale of a participation in any
of its Loans or participations in LC Disbursements to any assignee or
participant, other than to the Borrower, any Subsidiary or any Affiliate thereof
(as to which the provisions of this paragraph shall apply). The Borrower
consents to the foregoing and agrees, to the extent it may effectively do so
under applicable law, that any Lender acquiring a participation pursuant to the
foregoing arrangements may exercise against the Borrower rights of set-off and
counterclaim with respect to such participation as fully as if such Lender were
a direct creditor of the Borrower in the amount of such participation.

          (d)  Unless the Administrative Agent shall have received notice from
the Borrower prior to the date on which any payment is due to the Administrative
Agent for the account of the Lenders or the Issuing Bank hereunder that the
Borrower will not make such payment, the Administrative Agent may assume that
the Borrower has made such payment on such date in accordance herewith and may,
in reliance upon such assumption, distribute to the Lenders or the Issuing Bank,
as the case may be, the amount due.  In such event, if the Borrower has not in
fact made such payment, then each of the Lenders or the Issuing Bank, as the
case may be, severally agrees to repay to the Administrative Agent forthwith on
demand the amount so distributed to such Lender or Issuing Bank with interest
thereon, for each day from and including the date such amount is distributed to
it to but excluding the date of payment to the Administrative Agent, at the
greater of the Federal Funds Effective Rate and a rate determined by the
Administrative Agent in accordance with banking industry rules on interbank
compensation; provided, however, that the Borrower shall not be required to
              --------  -------                                            
reimburse any Lender for the payment of any such interest.

          (e)  If any Lender shall fail to make any payment required to be made
by it pursuant to Section 2.04(d) or (e), 2.05(b), 2.17(d) or 9.03(c), then the
Administrative Agent may, in its discretion (notwithstanding any contrary
provision hereof), apply any amounts thereafter received by the Administrative
Agent for the account of such Lender to satisfy such Lender's obligations under
such Sections until all such unsatisfied obligations are fully paid.

          SECTION 2.18.  Mitigation Obligations; Replacement of Lenders.  (a)
                         -----------------------------------------------      
If any Lender requests compensation under Section 2.14, or if the Borrower is
required to pay any additional amount to any Lender or any Governmental
Authority for the account of any Lender pursuant to Section 2.16, then such
Lender shall use reasonable efforts to designate a different lending office for
funding or booking its Loans hereunder or to assign its rights and obligations
hereunder to another of its offices, branches or affiliates, if, in the judgment
of such Lender, such designation or assignment (i) would eliminate or reduce
amounts payable pursuant to Section 2.14 or 2.16, as the case may be, in the
future and (ii) would not subject such Lender to any unreimbursed cost or
expense and would not otherwise be disadvantageous to such Lender.  The Borrower
hereby agrees to pay all reasonable costs and expenses incurred by any Lender in
connection with any such designation or assignment.
<PAGE>
 
                                                                              42

          (b)  If any Lender requests compensation under Section 2.14, or if the
Borrower is required to pay any additional amount to any Lender or any
Governmental Authority for the account of any Lender pursuant to Section 2.16,
or if any Lender defaults in its obligation to fund Loans hereunder, then the
Borrower may, at its sole expense and effort, upon notice to such Lender and the
Administrative Agent, require such Lender to assign and delegate, without
recourse (in accordance with and subject to the restrictions contained in
Section 9.04), all its interests, rights and obligations under this Agreement to
an assignee that shall assume such obligations (which assignee may be another
Lender, if a Lender accepts such assignment, or any other party); provided that
                                                                  --------     
(i) the Borrower shall have received the prior written consent of the
Administrative Agent (and, if a Revolving Commitment is being assigned, the
Issuing Bank), which consent shall not unreasonably be withheld, (ii) such
Lender shall have received payment of an amount equal to the outstanding
principal of its Loans and participations in LC Disbursements, accrued interest
thereon, accrued fees and all other amounts payable to it hereunder, from the
assignee (to the extent of such outstanding principal and accrued interest and
fees) or the Borrower (in the case of all other amounts) and (iii) in the case
of any such assignment resulting from a claim for compensation under Section
2.14 or payments required to be made pursuant to Section 2.16, such assignment
will result in a reduction in such compensation or payments.  A Lender shall not
be required to make any such assignment and delegation if, prior thereto, as a
result of a waiver by such Lender or otherwise, the circumstances entitling the
Borrower to require such assignment and delegation cease to apply.


                                  ARTICLE III

                         Representations and Warranties
                         ------------------------------

          Each of Catalytica and the Borrower represents and warrants to the
Lenders that:

          SECTION 3.01.  Organization; Powers.  Each of Catalytica, the Borrower
                         ---------------------                                  
and the Restricted Subsidiaries is duly organized, validly existing and in good
standing under the laws of the jurisdiction of its organization, has all
requisite power and authority to carry on its business as now conducted and,
except where the failure to do so, individually or in the aggregate, could not
reasonably be expected to result in a Material Adverse Effect, is qualified to
do business in, and is in good standing in, every jurisdiction where such
qualification is required.

          SECTION 3.02.  Authorization; Enforceability.  The Transactions to be
                         ------------------------------                        
entered into by each Loan Party are within such Loan Party's corporate powers
and have been duly authorized by all necessary corporate and, if required,
stockholder action.  This Agreement has been duly executed and delivered by each
of Catalytica and the Borrower and constitutes, and each other Loan Document to
which any Loan Party is to be a party, when executed and delivered by such Loan
Party, will constitute, a legal, valid and binding obligation of Catalytica, the
Borrower or such Loan Party (as the case may be), enforceable in accordance with
its terms, subject to applicable bankruptcy, insolvency, reorganization,
moratorium or other laws affecting creditors' rights generally and subject to
general principles of equity, regardless of whether considered in a proceeding
in equity or at law.
<PAGE>
 
                                                                              43

          SECTION 3.03.  Governmental Approvals; No Conflicts.  The Transactions
                         -------------------------------------                  
(a) do not require any material consent or approval of, registration or filing
with, or any other action by, any Governmental Authority, except (i) as required
by the FD&C Act in connection with the Acquisition, (ii) as required for the
Borrower to operate the Acquired Facilities (including environmental permits and
any other permits) and (iii) such as have been obtained or made and are in full
force and effect and except filings necessary to perfect Liens created under the
Loan Documents, (b) will not violate any applicable law or regulation material
to Catalytica, the Borrower and the Restricted Subsidiaries, taken as a whole,
or the charter, by-laws or other organizational documents of Catalytica, the
Borrower or any of the Restricted Subsidiaries or any order of any Governmental
Authority, (c) will not violate or result in a default under any indenture,
agreement (including any Acquisition Document) or other instrument binding upon
Catalytica, the Borrower or any of the Restricted Subsidiaries or its assets and
material to Catalytica, the Borrower and the Restricted Subsidiaries, taken as a
whole, or, except as specifically contemplated by the Acquisition Documents,
give rise to a right thereunder to require any payment in excess of $3,000,000
to be made by Catalytica, the Borrower or any of the Restricted Subsidiaries,
and (d) will not result in the creation or imposition of any Lien on any
material asset of Catalytica, the Borrower or any of the Restricted
Subsidiaries, except Liens created under the Loan Documents, Liens created by
the Deed of Easement and the Liens described in Schedule 6.02 that have been
created in connection with the Transactions.

          SECTION 3.04.  Financial Condition; No Material Adverse Change. (a)
                         ------------------------------------------------     
Catalytica has heretofore furnished to the Lenders its consolidated balance
sheet and statements of income, stockholders equity and cash flows (i) as of and
for the fiscal year ended December 31, 1997, reported on by Ernst & Young LLP,
independent public accountants, and (ii) as of and for the fiscal quarter and
the portion of the fiscal year ended March 31, 1998, certified by its chief
financial officer.  Such financial statements present fairly, in all material
respects, the financial position and results of operations and cash flows of
Catalytica and its consolidated subsidiaries as of such dates and for such
periods in accordance with GAAP as consistently applied by Catalytica, subject
to year-end audit adjustments and the absence of footnotes in the case of the
statements referred to in clause (ii) above.

          (b)  Catalytica has heretofore furnished to the Lenders its pro forma
consolidated balance sheet as of June 30, 1997, prepared giving effect to the
Transactions as if the Transactions had occurred on such date.  Such pro forma
consolidated balance sheet (i) has been prepared in good faith based on the same
assumptions used to prepare the pro forma financial statements included in the
Confidential Information Memorandum of the Borrower dated July 1997 (which
assumptions are believed by Catalytica and the Borrower to be reasonable under
the circumstances at such time and on the date of this Agreement), (ii) is
consistent in all material respects with the forecasts and other information
previously provided to the Lenders, (iii) is based on the best information
available to Catalytica and the Borrower after due inquiry, (iv) accurately
reflects all adjustments necessary to give effect to the Transactions and (v)
presents fairly, in all material respects, the pro forma financial position of
the Borrower and its consolidated Subsidiaries as of June 30, 1997, as if the
Transactions had occurred on such date.

          (c)  Except as disclosed in the financial statements referred to above
or the notes thereto or in the Information Memorandum and except for the
Disclosed Matters, 
<PAGE>
 
                                                                              44

after giving effect to the Transactions, none of Catalytica, the Borrower or the
Restricted Subsidiaries has, as of the Restatement Date, any material contingent
liabilities, unusual long-term commitments or unrealized losses.

          (d)  Since December 31, 1996 (or, in the case of the Acquired
Facilities, since June 25, 1997), there has been no material adverse change in
the business, assets, operations, properties, condition, financial or otherwise,
contingent liabilities (including potential environmental liabilities),
prospects or material agreements of or relating to Catalytica, the Borrower, the
Restricted Subsidiaries and the Acquired Facilities, taken as a whole.

          SECTION 3.05.  Properties.  (a)  Each of Catalytica, the Borrower and
                         -----------                                           
the Restricted Subsidiaries has good title to, or valid leasehold interests in,
all its real and personal property material to its business (including its
Mortgaged Properties), except for Liens permitted by Section 6.02 and minor
defects in title that do not materially interfere with its ability to conduct
its business as currently conducted.

          (b)  Each of Catalytica, the Borrower and the Restricted Subsidiaries
owns, or is licensed to use, all trademarks, tradenames, copyrights, patents and
other intellectual property material to the business of Catalytica, the Borrower
and the Restricted Subsidiaries, taken as a whole, and the use thereof by
Catalytica, the Borrower and the Restricted Subsidiaries does not infringe upon
the rights of any other Person, except for any such infringements that,
individually or in the aggregate, could not reasonably be expected to result in
a Material Adverse Effect.

          (c)  Schedule 3.05 sets forth the address of each real property that
is owned or material real property that is leased by Catalytica, the Borrower or
any of the Restricted Subsidiaries as of the Effective Date after giving effect
to the Transactions.

          (d)  As of the Restatement Date, none of Catalytica, the Borrower or
any of the Restricted Subsidiaries has received notice of, or has knowledge of,
any pending or contemplated condemnation proceeding affecting any Mortgaged
Property or any sale or disposition thereof in lieu of condemnation.  Neither
any Mortgaged Property nor any interest therein is subject to any material right
of first refusal, option or other contractual right to purchase such Mortgaged
Property or interest therein.

          SECTION 3.06.  Litigation and Environmental Matters.  (a)  There are
                         -------------------------------------                
no actions, suits or proceedings by or before any arbitrator or Governmental
Authority pending against or, to the knowledge of Catalytica or the Borrower,
threatened against or affecting Catalytica, the Borrower or any of the
Subsidiaries (i) as to which there is a reasonable possibility of an adverse
determination and that, if adversely determined, could reasonably be expected,
individually or in the aggregate, to result in a Material Adverse Effect (other
than the Disclosed Matters) or (ii) that involve any of the Loan Documents or
the Transactions.

          (b)  Except for the Disclosed Matters and except with respect to any
other matters that, individually or in the aggregate, could not reasonably be
expected to result in a Material Adverse Effect, none of Catalytica, the
Borrower or any of the Subsidiaries (i) has failed to comply with any
Environmental Law or to obtain, maintain or comply with any permit, license or
other approval required under any Environmental Law, (ii) has 
<PAGE>
 
                                                                              45

become subject to any Environmental Liability, (iii) has received notice of any
claim against it of any Environmental Liability or (iv) knows of any basis for
any Environmental Liability against it.

          (c)  Since the date of the Original Credit Agreement, there has been
no change in the status of the Disclosed Matters that, individually or in the
aggregate, has resulted in (i) a Material Adverse Effect or (ii) a material
increase in the likelihood that a Material Adverse Effect is reasonably likely
to occur.

          SECTION 3.07.  Compliance with Laws and Agreements.  Each of
                         ------------------------------------         
Catalytica, the Borrower and the Restricted Subsidiaries is in compliance with
all laws, regulations and orders of any Governmental Authority applicable to it
or its property and all indentures, agreements and other instruments binding
upon it or its property, except where the failure to be in such compliance,
individually or in the aggregate, could not reasonably be expected to result in
a Material Adverse Effect.

          SECTION 3.08.  Investment and Holding Company Status.  None of
                         --------------------------------------         
Catalytica, the Borrower or any of the Restricted Subsidiaries is (a) an
"investment company" as defined in, or subject to regulation under, the
Investment Company Act of 1940 or (b) a "holding company" as defined in, or
subject to regulation under, the Public Utility Holding Company Act of 1935.

          SECTION 3.09.  Taxes.  Each of Catalytica, the Borrower and the
                         ------                                          
Restricted Subsidiaries has timely filed or caused to be filed all Tax returns
and reports required to have been filed and has paid or caused to be paid all
Taxes required to have been paid by it, except (a) Taxes that are being
contested in good faith by appropriate proceedings and for which Catalytica, the
Borrower or such Restricted Subsidiary, as applicable, has set aside on its
books adequate reserves or (b) to the extent that the failure to do so could not
reasonably be expected to result in a Material Adverse Effect.

          SECTION 3.10.  ERISA.  No ERISA Event has occurred or is reasonably
                         ------                                              
expected to occur that, when taken together with all other such ERISA Events for
which liability is reasonably expected to occur, could reasonably be expected to
result in a Material Adverse Effect.  The present value of all accumulated
benefit obligations under each Plan (based on the assumptions used for purposes
of Statement of Financial Accounting Standards No. 87) did not, as of the date
of the most recent financial statements reflecting such amounts, exceed by more
than $3,000,000 the fair market value of the assets of such Plan, and the
present value of all accumulated benefit obligations of all underfunded Plans
(based on the assumptions used for purposes of Statement of Financial Accounting
Standards No. 87) did not, as of the date of the most recent financial
statements reflecting such amounts, exceed by more than $3,000,000 the fair
market value of the assets of all such underfunded Plans.

          SECTION 3.11.  Disclosure.  The Borrower has disclosed to the Lenders
                         -----------                                           
all agreements, instruments and corporate or other restrictions to which
Catalytica, the Borrower or any of the Restricted Subsidiaries is subject, and
all other matters known to any of them, that, individually or in the aggregate,
could reasonably be expected to result in a Material Adverse Effect.  Neither
the Information Memorandum nor any of the other reports, financial statements,
certificates or other information furnished by or on behalf of any Loan Party to
the Administrative Agent or any Lender in connection with the 
<PAGE>
 
                                                                              46

negotiation of this Agreement or any other Loan Document or delivered hereunder
or thereunder (as modified or supplemented by other information so furnished
prior to the time when this representation is being made or deemed made)
considered as a whole contains any material misstatement of fact or omits to
state any material fact necessary to make the statements therein, in the light
of the circumstances under which they were made, not misleading in any material
respect; provided that, with respect to projected financial information,
         --------
Catalytica and the Borrower represent only that such information was prepared in
good faith based upon assumptions believed to be reasonable at the time.

          SECTION 3.12.  Subsidiaries.  (a)  As of the Restatement Date,
                         -------------                                  
Catalytica does not have any direct subsidiaries other than the Borrower,
Catalytica Combustion and Advanced Technologies.  Schedule 3.12 sets forth the
name of, and the ownership interest of Catalytica, the Borrower and each of the
Restricted Subsidiaries in, each of their respective subsidiaries and identifies
each Restricted Subsidiary that is a Subsidiary Loan Party, in each case as of
the Effective Date.

          (b)  Advanced Sensor is an Inactive Subsidiary, or if such Restricted
Subsidiary ceases to be an Inactive Subsidiary, it has complied with Section
5.14.  As of the Effective Date, Advanced Sensor is the only Inactive
Subsidiary.

          SECTION 3.13.  Insurance.  Schedule 3.13 sets forth a description of
                         ----------                                           
all insurance maintained by or on behalf of the Borrower and the Restricted
Subsidiaries as of the Effective Date.  As of the Restatement Date, all due and
payable, material premiums in respect of such insurance have been paid.

          SECTION 3.14.  Labor Matters.  As of the Restatement Date, there are
                         --------------                                       
no strikes, lockouts or slowdowns against Catalytica, the Borrower or any
Restricted Subsidiary pending or, to the knowledge of Catalytica or the
Borrower, threatened.  The hours worked by and payments made to employees of
Catalytica, the Borrower and the Restricted Subsidiaries have not been in
violation of the Fair Labor Standards Act or any other applicable Federal,
state, local or foreign law dealing with such matters, except for such
violations that, individually or in the aggregate, could not reasonably be
expected to have a Material Adverse Effect.  All payments due from Catalytica,
the Borrower or any Restricted Subsidiary, or for which any claim may be made
against Catalytica, the Borrower or any Restricted Subsidiary, on account of
wages and employee health and welfare insurance and other benefits that are,
individually or in the aggregate, material to Catalytica, the Borrower and the
Restricted Subsidiaries, taken as a whole, have been paid or accrued as a
liability on the books of Catalytica, the Borrower or such Restricted
Subsidiary.  The consummation of the Transactions will not give rise to any
right of termination or right of renegotiation on the part of any union under
any collective bargaining agreement to which Catalytica, the Borrower or any
Restricted Subsidiary is bound.

          SECTION 3.15.  Solvency.  Immediately after the effectiveness of this
                         ---------                                             
Agreement on the Restatement Date and immediately following the making of each
Loan, if any,  made on the Restatement Date and after giving effect to the
application of the proceeds of such Loans, (a) the fair value of the assets of
the Loan Parties, taken as a whole, at a fair valuation, will exceed their debts
and liabilities, subordinated, contingent or otherwise; (b) the present fair
saleable value of the property of the Loan Parties, taken as a whole, will be
greater than the amount that will be required to pay the probable 
<PAGE>
 
                                                                              47

liability of their debts and other liabilities, subordinated, contingent or
otherwise, as such debts and other liabilities become absolute and matured; (c)
the Loan Parties, taken as a whole, will be able to pay their debts and
liabilities, subordinated, contingent or otherwise, as such debts and
liabilities become absolute and matured; and (d) the Loan Parties, taken as a
whole, will not have unreasonably small capital with which to conduct the
business in which they are engaged as such business is now conducted and is
proposed to be conducted following the Effective Date.

          SECTION 3.16.  Security Documents.  (a)  The Pledge Agreement is
                         -------------------                              
effective to create in favor of the Administrative Agent, for the ratable
benefit of the Secured Parties, a legal, valid and enforceable security interest
in the Collateral (as defined in the Pledge Agreement) and, when the Collateral
is delivered to the Administrative Agent and duly endorsed, the Pledge Agreement
shall create a fully perfected Lien on, and security interest in, all right,
title and interest of the pledgor thereunder in such Collateral, in each case
prior and superior in right to any other person, other than with respect to
Liens that are permitted by Section 6.02 and have a priority as a matter of law.

          (b)  The Security Agreement is effective to create in favor of the
Administrative Agent, for the ratable benefit of the Secured Parties, a legal,
valid and enforceable security interest in the Collateral (as defined in the
Security Agreement) and, when financing statements in appropriate form are filed
in the offices specified on Schedule 6 to the Perfection Certificate, such
security interest shall constitute a fully perfected Lien on, and security
interest in, all right, title and interest of the grantors thereunder in such
Collateral (other than the Intellectual Property (as defined in the Security
Agreement) in which a security interest may be perfected by filing, recording or
registering a security agreement, financing statement or analogous document in
the United States Patent and Trademark Office or the United States Copyright
Office, as applicable), to the extent a security interest in such Collateral may
be perfected by the filing of financing statements, in each case prior and
superior in right to any other person, other than with respect to Liens that are
permitted by Section 6.02 and have a priority as a matter of law.

          (c)  When the Security Agreement is filed in the United States Patent
and Trademark Office and the United States Copyright Office, the security
interest created thereunder shall constitute a fully perfected Lien on, and
security interest in, all right, title and interest of the Loan Parties (other
than the Non-Borrower Subsidiaries) in the Intellectual Property (as defined in
the Security Agreement) in which a security interest may be perfected by filing,
recording or registering a security agreement, financing statement or analogous
document in the United States Patent and Trademark Office or the United States
Copyright Office, as applicable, in each case prior and superior in right to any
other person, other than with respect to Liens expressly permitted by Section
6.02 (it being understood that subsequent recordings in the United States Patent
and Trademark Office and the United States Copyright Office may be necessary to
perfect a lien on registered trademarks, trademark applications and copyrights
acquired by the Loan Parties after the date hereof).

          (d)  The Mortgages are effective to create, subject to the exceptions
listed in or covered by each title insurance policy covering such Mortgages and
the Liens on the Mortgaged Properties described in Schedule 6.02, in favor of
the Administrative Agent, 
<PAGE>
 
                                                                              48

for the ratable benefit of the Secured Parties, a legal, valid and enforceable
Lien on all of the right, title and interest of the respective grantors under
the Mortgages in and to the Mortgaged Properties thereunder and the proceeds
thereof in which a Lien may be perfected by the filing of a mortgage, and when
the Mortgages are recorded in the offices specified on Schedule 3.16(d), each
such Lien shall constitute a Lien on, and security interest in, all right, title
and interest of such grantors in such Mortgaged Properties and the proceeds
thereof in which a Lien may be perfected by the filing of a mortgage, in each
case prior and superior in right to any other person, other than with respect to
the rights of persons pursuant to Liens that are permitted by Section 6.02 and
have a priority as a matter of law.

          SECTION 3.17.  Federal Reserve Regulations.  (a)  Neither Catalytica,
                         ----------------------------                          
the Borrower nor any of the Restricted Subsidiaries is engaged principally, or
as one of its important activities, in the business of extending credit for the
purpose of buying or carrying Margin Stock.

          (b)  No part of the proceeds of any Loan or any Letter of Credit will
be used, whether directly or indirectly, and whether immediately, incidentally
or ultimately, for any purpose that entails a violation of, or that is
inconsistent with, the provisions of the Regulations of the Board, including
Regulation U or X.

          SECTION 3.18.  Year 2000.  Any reprogramming required to permit the
                         ----------                                          
proper functioning, in and following the year 2000, of (i) the Borrower's and
the Subsidiaries' computer systems and (ii) to the Borrower's knowledge after
due inquiry, equipment containing embedded microchips (including systems and
equipment supplied by others or with which Borrower's or the Subsidiaries'
systems interface) and the testing of all such systems and equipment, as so
reprogrammed, will be completed prior to any expected failure date caused by a
year 2000 problem and in any case prior to December 31, 1999.  The cost to the
Borrower of such reprogramming and testing and of the reasonably foreseeable
consequences of year 2000 to the Borrower (including, without limitation,
reprogramming errors and the failure of others' systems or equipment) will not
result in a Default or a Material Adverse Effect.  Except for such of the
reprogramming referred to in the preceding sentence as may be necessary, the
computer and management information systems of the Borrower and the Subsidiaries
are and, with ordinary course upgrading and maintenance, will continue for the
term of this Agreement to be, sufficient to permit the Borrower and the
Subsidiaries to conduct their business without Material Adverse Effect.


                                  ARTICLE IV

                                  Conditions
                                  ----------

          SECTION 4.01.  [Intentionally omitted.]
<PAGE>
 
                                                                              49

          SECTION 4.02.  Each Credit Event.  The obligation of each Lender to
                         ------------------                                  
make a Loan on the occasion of any Borrowing, and of the Issuing Bank to issue,
amend, renew or extend any Letter of Credit, is subject to the satisfaction of
the following conditions:

          (a)  The representations and warranties of each Loan Party set forth
     in the Loan Documents shall be true and correct on and as of the date of
     such Borrowing or the date of issuance, amendment, renewal or extension of
     such Letter of Credit, as applicable, except to the extent that such
     representations and warranties expressly relate to an earlier date, in
     which case such representations and warranties, shall, to such extent, be
     true and correct as of such earlier date.

          (b)  At the time of and immediately after giving effect to such
     Borrowing or the issuance, amendment, renewal or extension of such Letter
     of Credit, as applicable, no Default shall have occurred and be continuing.

          (c)  On the date of such Borrowing, no Material GWI Occupancy is
     continuing.

          (d)  No default shall have occurred and be continuing under the Supply
     Agreement (i) that enables or permits GWI to terminate the Supply
     Agreement, if at the time the Guaranteed Revenues that are to be paid after
     such date exceed $50,000,000, or (ii) that enables or permits the Borrower
     to terminate the Supply Agreement, if at the time the Guaranteed Revenues
     that are to be paid after such date exceed $50,000,000, and GWI has not
     paid in excess of $25,000,000 due and owed to the Borrower under the Supply
     Agreement.

Each Borrowing and each issuance, amendment, renewal or extension of a Letter of
Credit shall be deemed to constitute a representation and warranty by Catalytica
and the Borrower on the date thereof as to the matters specified in paragraphs
(a) and (b) of this Section.


                                   ARTICLE V

                             Affirmative Covenants
                             ---------------------

          Until the Commitments have expired or been terminated and the
principal of and interest on each Loan and all fees payable hereunder and all
other expenses or amounts payable under any Loan Document shall have been paid
in full and all Letters of Credit shall have expired or terminated and all LC
Disbursements shall have been reimbursed, each of Catalytica and the Borrower
covenants and agrees with the Lenders that:

          SECTION 5.01.  Financial Statements and Other Information. Catalytica
                         -------------------------------------------           
will furnish to the Administrative Agent and each Lender:

          (a) within 90 days after the end of each fiscal year of Catalytica,
     (i) the audited consolidated and unaudited consolidating balance sheet and
     related statements of operations, stockholders' equity and cash flows of
     Catalytica, the 
<PAGE>
 
                                                                              50

     Borrower and the Subsidiaries as of the end of and for such year and (ii)
     the unaudited consolidating balance sheet and related statements of
     operations, stockholders' equity and cash flows of Catalytica, the Borrower
     and the Restricted Subsidiaries as of the end of and for such year, setting
     forth in each case in comparative form the figures for the previous fiscal
     year, in the case of such consolidated financial statements, reported on by
     Ernst & Young LLP or other independent public accountants of recognized
     national standing (without a "going concern" or like qualification or
     exception and without any qualification or exception as to the scope of
     such audit) to the effect that such consolidated financial statements
     present fairly in all material respects the financial condition and results
     of operations of Catalytica and its consolidated subsidiaries on a
     consolidated basis in accordance with GAAP consistently applied;

          (b) within 45 days after the end of each of the first three fiscal
     quarters of each fiscal year of Catalytica, (i) the consolidated and
     consolidating balance sheet and related statements of operations,
     stockholders' equity and cash flows of Catalytica, the Borrower and the
     Subsidiaries as of the end of and for such fiscal quarter and the then
     elapsed portion of the fiscal year and (ii) the unaudited consolidating
     balance sheet and related statements of operations, stockholders' equity
     and cash flows of Catalytica, the Borrower and the Restricted Subsidiaries
     as of the end of and for such fiscal quarter and the then elapsed portion
     of the fiscal year, setting forth in each case in comparative form the
     figures for the corresponding period or periods of (or, in the case of the
     balance sheet, as of the end of) the previous fiscal year, all certified by
     one of its Financial Officers as presenting fairly in all material respects
     the financial condition and results of operations of Catalytica and its
     consolidated subsidiaries on a consolidated basis in accordance with GAAP
     consistently applied, subject to normal year-end audit adjustments and the
     absence of footnotes;

          (c) within 30 days after the end of each of the first two fiscal
     months of each fiscal quarter of Catalytica, (i) the consolidated and
     consolidating balance sheet and related statements of operations,
     stockholders' equity and cash flows of Catalytica, the Borrower and the
     Subsidiaries as of the end of and for such fiscal month and then elapsed
     portion of the fiscal year, and (ii) the unaudited consolidating balance
     sheet and related statements of operations, stockholders' equity and cash
     flows of Catalytica, the Borrower and the Restricted Subsidiaries as of the
     end of and for such fiscal month and the then elapsed portion of the fiscal
     year, all certified by one of its Financial Officers as presenting in all
     material respects the financial condition and results of operations of
     Catalytica and its consolidated subsidiaries on a consolidated basis in
     accordance with GAAP consistently applied, subject to normal year-end audit
     adjustments and the absence of footnotes;

          (d) concurrently with any delivery of financial statements under
     clause (a) or (b) above, a certificate of a Financial Officer of the
     Borrower (i) certifying as to whether a Default of which Catalytica or the
     Borrower is aware has occurred and is continuing and, if such a Default has
     occurred and is continuing, specifying the details thereof and any action
     taken or proposed to be taken with respect thereto, (ii) setting forth
     reasonably detailed calculations demonstrating compliance with Sections
     6.13, 6.14 and 6.15 and (iii) stating 
<PAGE>
 
                                                                              51

     whether any change in GAAP or in the application thereof not previously
     disclosed to the Lenders has occurred since the date of Catalytica's
     audited financial statements referred to in Section 3.04 and, if any such
     change has occurred, specifying the effect of such change on the financial
     statements accompanying such certificate;

          (e) concurrently with any delivery of financial statements under
     clause (a) above, a certificate of the accounting firm that reported on
     such financial statements stating whether they obtained knowledge during
     the course of their examination of such financial statements of any Default
     (which certificate may be limited to the extent required by accounting
     rules or guidelines);

          (f) (i) at least 30 days prior to the commencement of each fiscal
     year of Catalytica and the Borrower, a detailed preliminary consolidated
     budget for such fiscal year (including a projected consolidated balance
     sheet and related statements of projected operations and cash flow as of
     the end of and for such fiscal year), (ii) within one month after the end
     of the prior fiscal year, a final version of such preliminary budget and
     (iii) promptly when available, any significant revisions of any such
     budget;

          (g) promptly after the same become publicly available, copies of all
     periodic and other reports, proxy statements and other materials filed by
     Catalytica, the Borrower or any Subsidiary with the Securities and Exchange
     Commission, or any Governmental Authority succeeding to any or all of the
     functions of said Commission, or with any national securities exchange, as
     the case may be; and

          (h) promptly following any request therefor, such other information
     regarding the operations, business affairs and financial condition of
     Catalytica, the Borrower or any Subsidiary (including information for each
     of Catalytica's and the Borrower's business lines), or compliance with the
     terms of any Loan Document, as the Administrative Agent or any Lender may
     reasonably request.

          SECTION 5.02.  Notices of Material Events.  Catalytica and the
                         ---------------------------                    
Borrower will furnish to the Administrative Agent and each Lender prompt written
notice of the following events of which Catalytica, the Borrower or any
Subsidiary is aware:

          (a) the occurrence of any Default;

          (b) the filing or commencement of any action, suit or proceeding by or
     before any arbitrator or Governmental Authority against or affecting
     Catalytica, the Borrower or any Affiliate thereof that, if adversely
     determined, could reasonably be expected to result in a Material Adverse
     Effect;

          (c) the occurrence of any ERISA Event that, alone or together with any
     other ERISA Events that have occurred, could reasonably be expected to
     result in liability of Catalytica, the Borrower and the Restricted
     Subsidiaries in an aggregate amount exceeding $3,000,000;
<PAGE>
 
                                                                              52

          (d) the occurrence of a Material GWI Occupancy or the existence of
     circumstances giving either party to the Supply Agreement the right to
     terminate the Supply Agreement; and

          (e) any other development that results in, or could reasonably be
     expected to result in, a Material Adverse Effect.

Each notice delivered under this Section shall be accompanied by a statement of
a Financial Officer or other executive officer of Catalytica setting forth the
details of the event or development requiring such notice and any action taken
or proposed to be taken with respect thereto.

          SECTION 5.03.  Information Regarding Collateral.  (a)  The Borrower
                         ---------------------------------                   
will furnish to the Administrative Agent prompt written notice of any change (i)
in any Loan Party's corporate name or in any trade name used to identify it in
the conduct of its business or in the ownership of its properties, (ii) in the
location of any Loan Party's chief executive office, its principal place of
business, any office in which it maintains books or records relating to
Collateral owned by it or any office or facility at which Collateral owned by it
is located (including the establishment of any such new office or facility),
(iii) in any Loan Party's identity or corporate structure or (iv) in any Loan
Party's Federal Taxpayer Identification Number.  Each of Catalytica and the
Borrower agrees not to effect or permit any change referred to in the preceding
sentence unless all filings have been made under the Uniform Commercial Code or
otherwise that are required in order for the Administrative Agent to continue at
all times following such change to have a valid, legal and perfected security
interest in all the Collateral.  The Borrower also agrees promptly to notify the
Administrative Agent if any material portion of the Collateral is damaged or
destroyed.

          (b)  Each year, at the time of delivery of annual financial statements
with respect to the preceding fiscal year pursuant to clause (a) of Section
5.01, the Borrower shall deliver to the Administrative Agent a certificate of a
Financial Officer of the Borrower (i) setting forth the information required
pursuant to Section 2 of the Perfection Certificate or confirming that there has
been no change in such information since the date of the Perfection Certificate
delivered on the Effective Date or the date of the most recent certificate
delivered pursuant to this Section and (ii) certifying that all Uniform
Commercial Code financing statements (including fixture filings, as applicable)
or other appropriate filings, recordings or registrations, including all
refilings, rerecordings and reregistrations, containing a description of the
Collateral have been filed of record in each governmental, municipal or other
appropriate office in each jurisdiction identified pursuant to clause (i) above
to the extent necessary to protect and perfect the security interests under the
Security Agreement for a period of not less than 18 months after the date of
such certificate (except as noted therein with respect to any continuation
statements to be filed within such period).

          SECTION 5.04.  Existence; Conduct of Business.  Each of Catalytica and
                         -------------------------------                        
the Borrower will, and will cause each of the Restricted Subsidiaries to, do or
cause to be done all things necessary to preserve, renew and keep in full force
and effect its legal existence and the rights, licenses, permits, privileges,
franchises, patents, copyrights, trademarks and trade names material to the
conduct of its business; provided that the 
                         --------                                          
<PAGE>
 
                                                                              53

foregoing shall not prohibit any merger, consolidation, liquidation or
dissolution permitted under Section 6.03.

          SECTION 5.05.  Payment of Obligations.  Each of Catalytica and the
                         -----------------------                            
Borrower will, and will cause each of the Restricted Subsidiaries to, pay its
Indebtedness and other obligations, including Tax liabilities, before the same
shall become delinquent or in default, except where the failure to make payment
could not reasonably be expected to result in a Material Adverse Effect.

          SECTION 5.06.  Maintenance of Properties.  Each of Catalytica and the
                         --------------------------                            
Borrower will, and will cause each of the Restricted Subsidiaries to, keep and
maintain all property material to the conduct of its business in good working
order and condition, ordinary wear and tear excepted.

          SECTION 5.07.  Insurance.  (a)  Each of Catalytica and the Borrower
                         ----------                                          
will, and will cause each of the Restricted Subsidiaries to, maintain, with
financially sound and reputable insurance companies:

          (i) insurance, in such amounts and with such deductibles and self-
     insured retention as are customarily maintained by companies in the same or
     similar business operating in the same or similar locations; and

          (ii) such other insurance as may be required by law.

          (b)  Fire and extended coverage policies (and any policies required to
be maintained pursuant to paragraph (c) below) maintained with respect to any
Collateral shall be endorsed or otherwise amended to include (i) a non-
contributing mortgage clause (regarding improvements to real property) and
lenders' loss payable clause (regarding personal property), in each case in
favor of the Administrative Agent and providing for losses thereunder to be
payable to the Administrative Agent or its designee, (ii) a provision to the
effect that neither the Borrower, the Administrative Agent nor any other party
shall be a coinsurer and (iii) such other provisions as the Administrative Agent
may reasonably require from time to time to protect the interests of the
Lenders.  Commercial general liability policies shall be endorsed to name the
Administrative Agent as an additional insured.  Business interruption policies
shall name the Administrative Agent as loss payee.  Each such policy referred to
in this paragraph also shall provide that it shall not be canceled, modified or
not renewed (i) by reason of nonpayment of premium except upon not less than 10
days' prior written notice thereof by the insurer to the Administrative Agent
(giving the Administrative Agent the right to cure defaults in the payment of
premiums) or (ii)  for any other reason except upon not less than 30 days' prior
written notice thereof by the insurer to the Administrative Agent.  The Borrower
shall deliver to the Administrative Agent, prior to the cancelation,
modification or nonrenewal of any such policy of insurance, a copy of a renewal
or replacement policy (or other evidence of renewal of a policy previously
delivered to the Administrative Agent) together with evidence satisfactory to
the Administrative Agent of payment of the premium therefor.

          (c)  If at any time the area in which any Mortgaged Property is
located is designated (i) a "flood hazard area" in any Flood Insurance Rate Map
published by the Federal Emergency Management Agency (or any successor agency),
the Borrower shall 
<PAGE>
 
                                                                              54

obtain flood insurance in such total amount as is customarily maintained by
companies in the same or similar business with respect to similar properties,
and otherwise comply with the National Flood Insurance Program as set forth in
the Flood Disaster Protection Act of 1973, as amended from time to time, or (ii)
a "Zone 1" area, the Borrower shall obtain earthquake insurance in such total
amount as is customarily maintained by companies in the same or similar business
with respect to similar properties.

          SECTION 5.08.  Casualty and Condemnation.  (a)  The Borrower will
                         --------------------------                        
furnish to the Administrative Agent and the Lenders prompt written notice of any
casualty or other insured damage to any portion of any Collateral having a fair
market value (as determined in good faith by the board of directors of the
Borrower) in excess of $2,000,000 or the commencement of any action or
proceeding for the taking of any Collateral or any part thereof or interest
therein having a fair market value (as determined in good faith by the board of
directors of the Borrower) in excess of $2,000,000 under power of eminent domain
or by condemnation or similar proceeding.

          (b)  If any event described in paragraph (a) of this Section results
in Net Proceeds (determined for purposes of this Section 5.08 without regard to
the final proviso in the definition of the term "Net Proceeds" and whether in
the form of insurance proceeds, condemnation award or otherwise), the
Administrative Agent is authorized to collect such Net Proceeds and, if received
by Catalytica, the Borrower or any Restricted Subsidiary, such Net Proceeds
shall be paid over to the Administrative Agent; provided that (i) to the extent
the aggregate Net Proceeds in respect of such event (other than proceeds of
business income insurance) are less than or equal to $15,000,000, such Net
Proceeds shall be paid over to the Borrower unless an Event of Default has
occurred and is continuing, and (ii) all proceeds of business income insurance
shall be paid over to the Borrower unless an Event of Default has occurred and
is continuing.  All such Net Proceeds retained by or paid over to the
Administrative Agent shall be held by the Administrative Agent and released from
time to time to pay the costs of repairing, restoring or replacing the affected
property in accordance with the terms of the applicable Security Document,
subject to the provisions of the applicable Security Document regarding
application of such Net Proceeds during a Default.

          (c)  If any Net Proceeds retained by or paid over to the
Administrative Agent as provided above continue to be held by the Administrative
Agent on the date that is 365 days after the receipt of such Net Proceeds, then
such Net Proceeds shall be applied to prepay Term Borrowings as provided in
Section 2.10(b), except as otherwise provided in the definition of the term Net
Proceeds.

          SECTION 5.09.  Books and Records; Inspection and Audit Rights.  Each
                         -----------------------------------------------      
of Catalytica and the Borrower will, and will cause each of the Restricted
Subsidiaries to, keep proper books of record and account in which full, true and
correct entries are made of all dealings and transactions in relation to its
business and activities.  Each of Catalytica and the Borrower will, and will
cause each of the Restricted Subsidiaries to, permit any representatives
designated by the Administrative Agent or any Lender, upon reasonable prior
notice, to visit and inspect its properties, to examine and make extracts from
its books and records, and to discuss its affairs, finances and condition with
its officers and independent accountants, all at such reasonable times and as
often as reasonably requested (but not more frequently than one time each year
if no Default 
<PAGE>
 
                                                                              55

exists), subject to the right of Catalytica and the Borrower to have a
representative present.

          SECTION 5.10.  Compliance with Laws.  Each of Catalytica and the
                         ---------------------                            
Borrower will, and will cause each of the Restricted Subsidiaries to, comply
with all laws, rules, regulations and orders (including but not limited to (i)
registration as required by the FD&C Act and (ii) maintenance of permits
required under Environmental Laws and any other permits as required in
connection with the Acquired Facilities) of any Governmental Authority
applicable to it or its property, except where the failure to do so,
individually or in the aggregate, could not reasonably be expected to result in
a Material Adverse Effect.

          SECTION 5.11.  Use of Proceeds and Letters of Credit.  The proceeds of
                         --------------------------------------                 
the Revolving Loans will be used only for general corporate purposes, including
on the Restatement Date to pay fees and expenses in connection with this
Agreement and the transactions in connection therewith.  No part of the proceeds
of any Loan will be used, whether directly or indirectly, for any purpose that
entails a violation of any of the Regulations of the Board, including
Regulations U and X.  Letters of Credit will be issued only for ordinary course
purposes.

          SECTION 5.12.  Additional Restricted Subsidiaries.  If any additional
                         -----------------------------------                   
Restricted Subsidiary that is not an Inactive Subsidiary is formed or acquired
after the Effective Date, the Borrower will notify the Administrative Agent and
the Lenders thereof and (a) if such Restricted Subsidiary is a Subsidiary Loan
Party, the Borrower will cause such Restricted Subsidiary to become a party to
the Guarantee Agreement and the Indemnity, Subrogation and Contribution
Agreement in the manner provided therein within three Business Days after such
Restricted Subsidiary is formed or acquired, (b) if such Restricted Subsidiary
is a Subsidiary Loan Party that is a Subsidiary of the Borrower, the Borrower
will cause such Restricted Subsidiary to become a party to each applicable
Security Document in the manner provided therein within three Business Days
after such Restricted Subsidiary is formed or acquired and promptly take such
actions to create and perfect Liens on such Restricted Subsidiary's assets to
secure the Obligations as the Administrative Agent or the Required Lenders shall
reasonably request, and (c) if any shares of capital stock or Indebtedness of
any additional Restricted Subsidiary are owned by or on behalf of any Loan
Party, the Borrower will cause such shares and promissory notes evidencing such
Indebtedness to be pledged pursuant to the Pledge Agreement within three
Business Days after such Restricted Subsidiary is formed or acquired (except
that, if such Restricted Subsidiary is a Foreign Subsidiary, shares of common
stock of such Restricted Subsidiary to be pledged pursuant to the Pledge
Agreement may be limited to 65% (or such lesser percentage as is necessary to
avoid adverse tax consequences to any Loan Party) of the outstanding shares of
common stock of such Restricted Subsidiary).

          SECTION 5.13.  Further Assurances.  (a)  Each of Catalytica and the
                         -------------------                                 
Borrower will, and will cause each Subsidiary Loan Party to, execute any and all
further documents, financing statements, agreements and instruments, and take
all such further actions (including the filing and recording of financing
statements, fixture filings, mortgages, deeds of trust and other documents),
that may be required under any applicable law, or which the Administrative Agent
or the Required Lenders may reasonably request, to effectuate the transactions
contemplated by the Loan Documents or 
<PAGE>
 
                                                                              56

to grant, preserve, protect or perfect the Liens created or intended to be
created by the Security Documents or the validity or priority of any such Lien,
all at the expense of the Loan Parties. Catalytica and the Borrower also agree
to provide to the Administrative Agent, from time to time upon request, evidence
reasonably satisfactory to the Administrative Agent as to the perfection and
priority of the Liens created or intended to be created by the Security
Documents.

          (b)  If any material assets (including any real property or
improvements thereto or any interest therein) are acquired by Catalytica, the
Borrower or any Restricted Subsidiary that is a Subsidiary of the Borrower after
the Effective Date (other than assets constituting Collateral under the Security
Agreement that become subject to the Lien of the Security Agreement upon
acquisition thereof), the Borrower will notify the Administrative Agent and the
Lenders thereof, and, if requested by the Administrative Agent or the Required
Lenders, the Borrower will cause such assets to be subjected to a Lien securing
the Obligations and will take, and cause such Subsidiary Loan Parties to take,
such actions as shall be necessary or reasonably requested by the Administrative
Agent to grant and perfect such Liens, including actions described in paragraph
(a) of this Section, all at the expense of the Borrower.


                                   ARTICLE VI

                               Negative Covenants
                               ------------------

          Until the Commitments have expired or terminated and the principal of
and interest on each Loan and all fees payable hereunder have been paid in full
and all Letters of Credit have expired or terminated and all LC Disbursements
shall have been reimbursed, each of Catalytica and the Borrower covenants and
agrees with the Lenders that:

          SECTION 6.01.  Indebtedness; Certain Equity Securities.  (a)
                         ----------------------------------------      
Catalytica and the Borrower will not, and Catalytica and the Borrower will not
permit any Restricted Subsidiary to, create, incur, assume or permit to exist
any Indebtedness, except:

          (i) Indebtedness created under the Loan Documents and the Original
     Credit Agreement;

          (ii) Indebtedness existing on the date hereof and set forth in
     Schedule 6.01 and extensions, renewals and replacements of any such
     Indebtedness that do not increase the outstanding principal amount thereof
     by more than 5% or result in an earlier maturity date or decreased weighted
     average life thereof;

          (iii) Indebtedness arising from loans and advances permitted by
     Section 6.04(e);

          (iv) Guarantees by one Loan Party or Restricted Subsidiary of
     Indebtedness of another Loan Party or Restricted Subsidiary; provided that
                                                                  --------     
     (A) Guarantees by Catalytica, the Borrower or any Subsidiary Loan Party of
     Indebtedness of any Restricted Subsidiary that is not a Loan Party,  (B)
     Guarantees by Catalytica, the Borrower or any Subsidiary of the Borrower of
     Indebtedness of Non-Borrower 
<PAGE>
 
                                                                              57

     Subsidiaries and (C) Guarantees by Catalytica Combustion or Advanced
     Technologies of Indebtedness of other Non-Borrower Subsidiaries all shall
     be subject to Section 6.04;

          (v) Indebtedness of the Borrower or any Restricted Subsidiary incurred
     to finance  Capital Expenditures, including Capital Lease Obligations and
     any Indebtedness assumed in connection Capital Expenditures or secured by a
     Lien on any fixed or capital assets prior to the acquisition thereof, and
     extensions, renewals and replacements of any such Indebtedness that do not
     increase the outstanding principal amount thereof by more than 5% or result
     in an earlier maturity date or decreased weighted average life thereof;
                                                                            
     provided that (A) such Indebtedness is incurred prior to or within 90 days
     --------                                                                  
     after the completion of such Capital Expenditures and (B) the aggregate
     principal amount of Indebtedness permitted by this clause (v) shall not
     exceed $25,000,000 at any time outstanding;

          (vi) Indebtedness of any Person that becomes a Restricted Subsidiary
     after the date hereof; provided that (A) such Indebtedness exists at the
                            --------                                         
     time such Person becomes a Restricted Subsidiary or is created in
     contemplation of or in connection with such Person becoming a Restricted
     Subsidiary and (B) the aggregate principal amount of Indebtedness permitted
     by this clause (vi) shall not exceed $10,000,000 at any time outstanding;
     and

          (vii) other unsecured Indebtedness in an aggregate principal amount
     not exceeding $25,000,000 at any time outstanding.

          (b)  Neither Catalytica nor the Borrower will, nor will they permit
any Restricted Subsidiary to, issue any preferred stock or be or become (except
to the extent permitted by Section 6.04(d), 6.04(i) or 6.08) liable in respect
of any obligation (contingent or otherwise) to purchase, redeem, retire, acquire
or make any other payment in respect of any shares of capital stock of
Catalytica, the Borrower or any Subsidiary or any option, warrant or other right
to acquire any such shares of capital stock other than (i) the issuance of the
Junior Preferred Stock by the Borrower pursuant to the Junior Preferred Purchase
Agreement, (ii) the issuance of Series C Preferred Stock by the Borrower
pursuant to the Share Exchange Agreement, (iii) the redemption of the MSCP Stock
upon a change of control as defined in the Investment Agreement or in connection
with any obligation to repurchase at any time after July 1, 2005, the Class A
Common Stock and the Class B Common Stock, as described in the Investment
Agreement, and (iv) the redemption of the Series B Preferred Stock of the
Borrower on or after October 1, 2002, in accordance with the terms of such
Preferred Stock and (v) the issuance of capital stock of Catalytica Combustion.

          SECTION 6.02.  Liens.  Catalytica and the Borrower will not, and
                         ------                                           
Catalytica and the Borrower will not permit any Restricted Subsidiary to,
create, incur, assume or permit to exist any Lien on any property or asset now
owned or hereafter acquired by it, or assign or sell any income or revenues
(including accounts receivable) or rights in respect of any thereof, except:

          (a) Liens created under the Loan Documents and the Original Credit
     Agreement;
<PAGE>
 
                                                                              58

          (b) Permitted Encumbrances;

          (c) Liens created under the Deed of Easement;

          (d) any Lien on any property or asset of Catalytica, the Borrower or
     any Restricted Subsidiary existing on the date hereof and set forth in
     Schedule 6.02; provided that (i) such Lien shall not apply to any other
                    --------                                                
     property or asset of Catalytica, the Borrower or any Restricted Subsidiary
     and (ii) such Lien shall secure only those obligations that it secures on
     the date hereof and extensions, renewals and replacements thereof that do
     not increase the outstanding principal amount thereof by more than 5%;

          (e) any Lien existing on any property or asset prior to the
     acquisition thereof by Catalytica, the Borrower or any Restricted
     Subsidiary or existing on any property or asset of any Person that becomes
     a Restricted Subsidiary after the date hereof prior to the time such Person
     becomes a Restricted Subsidiary; provided that (i) such Lien is not created
                                      --------                                  
     in contemplation of or in connection with such acquisition or such Person
     becoming a Restricted Subsidiary, as the case may be, (ii) such Lien shall
     not apply to any other property or assets of Catalytica, the Borrower or
     any Restricted Subsidiary and (iii) such Lien shall secure only those
     obligations that it secures on the date of such acquisition or the date
     such Person becomes a Restricted Subsidiary, as the case may be, and
     extensions, renewals and replacements thereof that do not increase the
     outstanding principal amount thereof by more than 5%; and

          (f) Liens on fixed or capital assets acquired, constructed or improved
     by Catalytica, the Borrower or any Restricted Subsidiary; provided that (i)
                                                               --------         
     such security interests secure Indebtedness permitted by clause (v) of
     Section 6.01(a), (ii) such security interests and the Indebtedness secured
     thereby are incurred prior to or within 90 days after such acquisition or
     the completion of such construction or improvement, (iii) the Indebtedness
     secured thereby does not exceed the cost of acquiring, constructing or
     improving such fixed or capital assets and (iv) such security interests
     shall not apply to any other property or assets of Catalytica, the Borrower
     or any Restricted Subsidiary.

          SECTION 6.03.  Fundamental Changes.  (a)  Catalytica and the Borrower
                         --------------------                                  
will not and will not permit any Restricted Subsidiary to, merge into or
consolidate with any other Person, or permit any other Person to merge into or
consolidate with it, or liquidate or dissolve, except that, if at the time
thereof and immediately after giving effect thereto no Event of Default shall
have occurred and be continuing (i) any Restricted Subsidiary may merge into the
Borrower in a transaction in which the Borrower is the surviving corporation,
(ii) any Restricted Subsidiary may merge into any Subsidiary Loan Party in a
transaction in which the surviving entity is a Subsidiary Loan Party, (iii) any
Restricted Subsidiary that is not a Loan Party may merge into any Restricted
Subsidiary that is not a Loan Party and (iv) any Restricted Subsidiary may
liquidate or dissolve if the Borrower determines in good faith that such
liquidation or dissolution is in the best interests of the Borrower and is not
materially disadvantageous to the Lenders; provided that any such merger
                                           --------                     
involving a Person that is not a wholly owned Restricted Subsidiary immediately
prior to such merger shall not be permitted unless also permitted by Section
6.04.
<PAGE>
 
                                                                              59

          (b)  Catalytica and the Borrower will not, and will not permit any of
the Restricted Subsidiaries to, engage to any material extent in any business
other than businesses of the type conducted by Catalytica, the Borrower and the
Restricted Subsidiaries on the date of execution of this Agreement and
businesses reasonably related thereto.

          SECTION 6.04.  Investments, Loans, Advances, Guarantees and
                         --------------------------------------------
Acquisitions.  Catalytica and the Borrower will not, and will not permit any of
- -------------                                                                  
the Restricted Subsidiaries to, purchase, hold or acquire (including pursuant to
any merger with any Person that was not a wholly owned Restricted Subsidiary
prior to such merger) any capital stock, evidences of indebtedness or other
securities (including the purchase or exercise of any option, warrant or other
right to acquire any of the foregoing) of, make or permit to exist any loans or
advances to, Guarantee any obligations of, or make or permit to exist any
investment or any other interest in, any other Person, or purchase or otherwise
acquire (in one transaction or a series of transactions) any assets of any other
Person constituting a business unit, except:

          (a) the Acquisition;

          (b) Permitted Investments;

          (c) investments existing on the date hereof and set forth on Schedule
     6.04, to the extent such investments would not be permitted under any other
     clause of this Section;

          (d) subject to the final paragraph of this Section, investments by
     Catalytica, the Borrower and the Restricted Subsidiaries in Catalytica, the
     Borrower and the Restricted Subsidiaries; provided that any shares of
                                               --------                   
     capital stock issued in connection with such investments shall be pledged
     pursuant to the Pledge Agreement (subject to the limitations applicable to
     common stock of a Foreign Subsidiary referred to in Section 5.12);

          (e) subject to the final paragraph of this Section, loans or advances
     made by Catalytica, the Borrower and the Restricted Subsidiaries to
     Catalytica, the Borrower and the Restricted Subsidiaries; provided that any
                                                               --------         
     such loans and advances made by a Loan Party shall be evidenced by a
     promissory note pledged pursuant to the Pledge Agreement;

          (f) Subject to the final paragraph of this Section, Guarantees
     constituting Indebtedness permitted by Section 6.01;

          (g) investments, securities or other interests received in connection
     with the bankruptcy or reorganization of, or settlement of delinquent
     accounts and disputes with, customers and suppliers, in each case in the
     ordinary course of business;

          (h) loans and advances to officers, directors and employees of
     Catalytica, the Borrower and the Restricted Subsidiaries made in the
     ordinary course of business and not exceeding $3,500,000 in the aggregate
     at any time outstanding;
<PAGE>
 
                                                                              60

          (i) investments, loans, advances and Guarantees not otherwise
     permitted above so long as the amount of such investments, loans, advances
     and Guarantees does not exceed $15,000,000 in the aggregate at any time
     outstanding; and

          (j) payments to Catalytica Combustion and its subsidiaries permitted
     by Section 6.09(e).

          Notwithstanding the provisions of Section 6.04(d), (e) and (f) and
except as otherwise provided in Section 6.04(i), (a) the amount of (i)
investments by the Loan Parties made after the Effective Date in Restricted
Subsidiaries that are not Loan Parties, (ii) loans and advances by Loan Parties
made after the Effective Date to Restricted Subsidiaries that are not Loan
Parties and (iii) Guarantees entered into by any Loan Party after the Effective
Date of Indebtedness of Restricted Subsidiaries that are not Loan Parties shall
not exceed $5,000,000 in the aggregate at any time outstanding, (b) the amount
of (i) investments made by Catalytica, the Borrower or any Subsidiary of the
Borrower after the Effective Date in Catalytica Combustion or any of its
subsidiaries, (ii) loans and advances made by Catalytica, the Borrower or any
Subsidiary of the Borrower after the Effective Date to Catalytica Combustion or
any of its subsidiaries and (iii) Guarantees entered into by Catalytica, the
Borrower or any Subsidiary of the Borrower after the Effective Date of
Indebtedness of Catalytica Combustion or any of its subsidiaries shall not
exceed $5,000,000 in the aggregate in any fiscal year of Catalytica, provided
that any portion of such amount not used in such fiscal year (including any
portion attributable to this proviso) will be added to the permitted amount for
the succeeding fiscal year, (c) the aggregate amount of (i) investments made by
Catalytica, the Borrower or any Subsidiary of the Borrower after the Effective
Date in Advanced Technologies or any of its subsidiaries, (ii) loans and
advances made by Catalytica, the Borrower or any Subsidiary of the Borrower
after the Effective Date to Advanced Technologies or any of its subsidiaries and
(iii) Guarantees entered into by Catalytica, the Borrower or any Subsidiary of
the Borrower after the Effective Date of Indebtedness of Advanced Technologies
or any of its subsidiaries shall not exceed $1,000,000 in the aggregate in any
fiscal year of Catalytica, provided that any portion of such amount not used in
such fiscal year (including any portion attributable to this proviso) will be
added to the permitted amount for the succeeding fiscal year, (d) none of
Catalytica, the Borrower or any Subsidiary of the Borrower shall after the
Effective Date make any investment in or loan or advance to or Guarantee any
Indebtedness of any Non-Borrower Subsidiary other than Catalytica Combustion,
Advanced Technologies and their respective subsidiaries, (e) Advanced
Technologies and its subsidiaries shall not make after the Effective Date any
investment in or loan or advance to or Guarantee any Indebtedness of any other
Non-Borrower Subsidiaries other than their respective subsidiaries, (f) prior to
the Catalytica Combustion Release Date, neither Catalytica Combustion nor any of
its subsidiaries shall make after the Effective Date any investment in or loan
or advance to or Guarantee any Indebtedness of any Non-Borrower Subsidiaries
other than Catalytica Combustion and its subsidiaries and (g) on and after the
Catalytica Combustion Release Date, none of Catalytica, the Borrower or any
Restricted Subsidiary shall make any investment in or loan or advance to or
Guarantee any Indebtedness of Catalytica Combustion or any of its subsidiaries.

          SECTION 6.05.  Asset Sales.  Catalytica and the Borrower will not, and
                         ------------                                           
will not permit any of the Restricted Subsidiaries to, sell, transfer, lease or
otherwise dispose of any asset, including any capital stock, nor will Catalytica
or the Borrower 
<PAGE>
 
                                                                              61

permit the Borrower or any Restricted Subsidiary to issue any additional shares
of its capital stock or other ownership interest in the Borrower or such
Restricted Subsidiary, as the case may be, except:

          (a) sales or leases of inventory, used or surplus furniture, used or
     surplus equipment and Permitted Investments in the ordinary course of
     business;

          (b) sales, transfers and dispositions to Catalytica, the Borrower or a
     Restricted Subsidiary; provided that any such sales, transfers or
                            --------                                  
     dispositions involving a Restricted Subsidiary that is not a Loan Party
     shall be made in compliance with Section 6.09;

          (c) sales, transfers and dispositions of assets (other than capital
     stock of the Borrower or a Subsidiary) that are not permitted by any other
     clause of this Section; provided that the aggregate fair market value of
                             --------                                        
     all assets sold, transferred or otherwise disposed of in reliance upon this
     clause (c) shall not exceed $10,000,000 during any fiscal year of the
     Borrower or $25,000,000 during the term of this Agreement; provided that
     (i) all sales, transfers, leases and other dispositions permitted pursuant
     to this Section 6.05(c) shall be made for fair value and for consideration
     at least 75% of which is cash, (ii) Catalytica, the Borrower and the
     Restricted Subsidiaries may sell, transfer, lease or otherwise dispose of
     assets having an aggregate value of $2,000,000 in each fiscal year of
     Catalytica without regard to clause (i) of this proviso solely for non-cash
     consideration or for consideration less than 75% of which is cash, and
     (iii) any such sale, transfer or other disposition may be made for
     consideration consisting of assets to be used in the same line of business
     as the assets disposed of without regard to clause (i) of this proviso.

          (d) issuances by the Borrower of Junior Preferred Stock and Series C
     Preferred Stock in accordance with the Acquisition Documents;

          (e) issuances of capital stock by Catalytica Combustion;

          (f) Restricted Payments permitted by Section 6.08; and

          (g) issuances of the capital stock of any Restricted Subsidiary (i)
     pro rata to the holders of such Restricted Subsidiary's capital stock or
     (ii) to any Loan Party; provided that such capital stock issued to a Loan
                             --------                                         
     Party shall be pledged pursuant to the Pledge Agreement.

          SECTION 6.06.  Sale and Lease-Back Transactions.  Catalytica and the
                         ---------------------------------                    
Borrower will not, and will not permit any of the Restricted Subsidiaries to,
enter into any arrangement, directly or indirectly, with any person whereby it
shall sell or transfer any property, real or personal, used or useful in its
business, whether now owned or hereafter acquired, and thereafter rent or lease
such property or other property which it intends to use for substantially the
same purpose or purposes as the property being sold or transferred, provided
that, subject to Section 6.05, the Borrower and the Restricted Subsidiaries may
enter into any such transaction to the extent the Capital Lease Obligation and
Liens associated therewith would be permitted by Sections 6.01(a)(v) and 6.02.
<PAGE>
 
                                                                              62

          SECTION 6.07.  Hedging Agreements.  Catalytica and the Borrower will
                         -------------------                                  
not, and will not permit any of the Restricted Subsidiaries to, enter into any
Hedging Agreement, other than Hedging Agreements entered into in the ordinary
course of business to hedge or mitigate risks to which Catalytica, the Borrower
or any Restricted Subsidiary is exposed in the conduct of its business or the
management of its interest rate exposures and similar liabilities.

          SECTION 6.08.  Restricted Payments.  Catalytica and the Borrower will
                         --------------------                                  
not, and will not permit any Restricted Subsidiary to, declare or make, or agree
to pay or make, directly or indirectly, any Restricted Payment, except (a)
Catalytica and its subsidiaries may declare and pay dividends pro rata to their
stockholders with respect to their capital stock payable solely in additional
shares of their capital stock, (b) the Borrower and the Restricted Subsidiaries
may declare and pay dividends to Loan Parties and (c) Catalytica may make
Restricted Payments, not exceeding $2,000,000 during any fiscal year, with
respect to stock option plans or other benefit plans for management or employees
of Catalytica, the Borrower and the Restricted Subsidiaries approved by their
respective boards of directors.

          SECTION 6.09.  Transactions with Affiliates.  Catalytica and the
                         -----------------------------                    
Borrower will not, and will not permit any Restricted Subsidiary to, sell, lease
or otherwise transfer any property or assets to, or purchase, lease or otherwise
acquire any property or assets from, or otherwise engage in any other
transactions with, any of its Affiliates, except (a) transactions that are at
prices and on terms and conditions not less favorable to Catalytica, the
Borrower or such Restricted Subsidiary than could be obtained on an arm's-length
basis from unrelated third parties, (b) subject to Section 6.04 and the other
provisions of this Article VI, transactions between or among Catalytica, the
Borrower and the Subsidiary Loan Parties not involving any other Affiliate, (c)
any Restricted Payment permitted by Section 6.08, (d) payments in respect of
Taxes made by the Borrower or any of the Restricted Subsidiaries to Catalytica
and (e) payments made by Catalytica to Catalytica Combustion or its subsidiaries
in the amount of the actual reduction in the amount of Taxes that would have
been paid by Catalytica that is directly attributable to the net operating
losses or similar tax benefits provided by the Unrestricted Subsidiaries.

          SECTION 6.10.  Restrictive Agreements.  Catalytica and the Borrower
                         -----------------------                             
will not, and will not permit any Restricted Subsidiary to, directly or
indirectly, enter into, incur or permit to exist any agreement or other
arrangement that prohibits, restricts or imposes any condition upon (a) the
ability of Catalytica, the Borrower or any Restricted Subsidiary to create,
incur or permit to exist any Lien upon any of its property or assets, or (b) the
ability of any Restricted Subsidiary to pay dividends or other distributions
with respect to any shares of its capital stock or to make or repay loans or
advances to the Borrower or any other Restricted Subsidiary or to Guarantee
Indebtedness of the Borrower or any other Restricted Subsidiary; provided that
                                                                 --------     
(i) the foregoing shall not apply to restrictions and conditions imposed by law
or by any Loan Document, (ii) the foregoing shall not apply to restrictions and
conditions existing on the date hereof identified on Schedule 6.10 (but shall
apply to any amendment or modification expanding the scope of any such
restriction or condition), (iii) the foregoing shall not apply to customary
restrictions and conditions contained in agreements relating to the sale of a
Restricted Subsidiary pending such sale, provided such restrictions and
conditions apply only to the Restricted Subsidiary that is to be sold and such
sale is permitted hereunder, 
<PAGE>
 
                                                                              63

(iv) clause (a) of the foregoing shall not apply to restrictions or conditions
imposed by any agreement relating to secured Indebtedness permitted by this
Agreement if such restrictions or conditions apply only to the property or
assets securing such Indebtedness and (v) clause (a) of the foregoing shall not
apply to customary provisions in leases restricting the assignment thereof.

          SECTION 6.11.  Sterile Facility Pay-Out.  The Borrower will not make
                         ------------------------                             
any payment to GWI in connection with the Sterile Facility Pay-Out at any time
when (a) an Event of Default has occurred or (b) a failure by the Borrower to
make any payment when due under this Agreement has occurred, provided that all
                                                             --------         
such payments in connection with the Sterile Facility Pay-Out that were deferred
following the occurrence of an Event of Default or during the continuance of a
payment default under this Agreement, together with interest thereon at the rate
of 10% per annum from the date originally due to the date actually paid, may be
made (i) upon 60 days following the waiver, as provided in Section 9.02, of all
such Events of Default or (ii) immediately upon the cure of all such payment
defaults, provided that the Borrower's Obligations have not been declared to be
or become immediately due and payable pursuant to Article VII or that any such
acceleration of such Obligations has been duly rescinded.

          SECTION 6.12.  Amendment of Material Documents.  (a)  Catalytica and
                         --------------------------------                     
the Borrower will not, and will not permit any Restricted Subsidiary to, amend,
modify or waive any of its rights under (i) its certificate of incorporation,
by-laws or other organizational documents, (ii) the Asset Purchase Agreement,
(iii) the Environmental Agreement dated June 22, 1997, between GWI and
Catalytica or (iv) the other Acquisition Documents (other than the Supply
Agreement), except for amendments, modifications or waivers that are not
materially adverse to the Lenders.

          (b)  The Borrower will not (i) amend the Supply Agreement to reduce
the amounts of the Guaranteed Revenues or extend the scheduled date of payment
of any Guaranteed Revenues, or (ii) otherwise amend, modify or waive any of its
rights under the Supply Agreement, except for amendments, modifications or
waivers under this clause (ii) that are not materially adverse to the Lenders.

          SECTION 6.13.  Capital Expenditures.  Catalytica and the Borrower will
                         ---------------------                                  
not permit the aggregate amount of Capital Expenditures (other than the
reinvestment in accordance with the definition of Net Proceeds of the proceeds
of dispositions of assets) made by Catalytica, the Borrower and the Restricted
Subsidiaries in any fiscal year to exceed the amount (the "Base Amount") set
forth below opposite such year:

          Fiscal Year                            Amount
          -----------                            ------

             1998                             $40,000,000
          Thereafter                          $30,000,000

The amount of permitted Capital Expenditures set forth above in respect of any
fiscal year shall be increased by the lesser of (a) the Base Amount for the
immediately preceding fiscal year and (b) the difference between (i) the sum of
the Base Amount for the immediately preceding fiscal year and the unused Base
Amount for the second preceding fiscal year and (ii) the amount of Capital
Expenditures made during the immediately preceding fiscal year.
<PAGE>
 
                                                                              64

          SECTION 6.14.  Leverage Ratio.  Catalytica will not permit (a) as of
                         --------------                                       
March 31, 1998, the Leverage Ratio, which shall be calculated using Adjusted
Consolidated EBITDA for the two-fiscal-quarter period ending March 31, 1998,
multiplied by two, to be in excess of the ratio 4.50 to 1.00, (b) as of June 30,
1998, the Leverage Ratio, which shall be calculated using Adjusted Consolidated
EBITDA for the three-fiscal-quarter period ending June 30, 1998, multiplied by
4/3, to be in excess of the ratio 4.25 to 1.00 or (c) as of the end of any four-
fiscal-quarter period ending on any date or during any period set forth below,
the Leverage Ratio to be in excess of the ratio set forth below opposite such
period:
<TABLE>
<CAPTION>
 
                Period                       Amount
                ------                       ------
          <S>                            <C>
 
          September 30, 1998              4.00 to 1.00
          December 31, 1998               3.50 to 1.00
          March 31, 1999                  3.50 to 1.00
          June 30, 1999 and thereafter    3.00 to 1.00
</TABLE>

          SECTION 6.15.  Consolidated Interest Expense Coverage Ratio.
                         ---------------------------------------------
Catalytica will not permit the ratio of (a) Consolidated EBITDA to (b)
Consolidated Interest Expense less Consolidated Cash Interest Income (i) for the
two-fiscal-quarter period ending March 31, 1998, to be less than 2.50 to 1.00,
(ii) for the three-fiscal-quarter period ending June 30, 1998, to be less than
2.75 to 1.00 or (iii) for any four-fiscal-quarter period ending on any date
during any period set forth below to be less than the ratio set forth below
opposite such period:

                 Period                                Ratio
                 ------                                -----

          September 30, 1998                        3.00 to 1.00
          December 31, 1998 and thereafter          3.50 to 1.00


                                  ARTICLE VII

                               Events of Default
                               -----------------

          If any of the following events ("Events of Default") shall occur:
                                           -----------------               

          (a) the Borrower shall fail to pay any principal of any Loan or any
     reimbursement obligation in respect of any LC Disbursement when and as the
     same shall become due and payable, whether at the due date thereof or at a
     date fixed for prepayment thereof or otherwise;

          (b) the Borrower shall fail to pay any interest on any Loan or any fee
     or any other amount (other than an amount referred to in clause (a) of this
     Article) payable under this Agreement or any other Loan Document, when and
     as the same shall become due and payable, and such failure shall continue
     unremedied for a period of five Business Days;

          (c) any representation or warranty that is qualified as to materiality
     and made or deemed made by or on behalf of Catalytica, the Borrower or any
<PAGE>
 
                                                                              65

     Restricted Subsidiary in or in connection with any Loan Document or any
     amendment or modification thereof or waiver thereunder, or in any report,
     certificate, financial statement or other document furnished pursuant to or
     in connection with any Loan Document or any amendment or modification
     thereof or waiver thereunder, shall prove to have been incorrect when made
     or deemed made or any such representation or warranty that is not qualified
     as to materiality shall prove to have been incorrect in any material
     respect when made or deemed made;

          (d) Catalytica or the Borrower shall fail to observe or perform any
     covenant, condition or agreement contained in Section 5.02, 5.04 (with
     respect to the existence of Catalytica or the Borrower) or 5.11 or in
     Article VI;

          (e) any Loan Party shall fail to observe or perform any covenant,
     condition or agreement contained in any Loan Document (other than those
     specified in clause (a), (b) or (d) of this Article), and such failure
     shall continue unremedied for a period of 30 days after notice thereof from
     the Administrative Agent to the Borrower (which notice will be given at the
     request of any Lender);

          (f)  Catalytica, the Borrower or any Restricted Subsidiary shall fail
     to make any payment (whether of principal or interest and regardless of
     amount) in respect of any Material Indebtedness, when and as the same shall
     become due and payable;

          (g) the Supply Agreement shall cease to be in full force and effect
     for any reason prior to December 31, 2001, if at the time the Guaranteed
     Revenues that are to be paid after such date exceed $50,000,000;

          (h) any event or condition occurs that results in any Material
     Indebtedness becoming due prior to its scheduled maturity or that enables
     or permits the holder or holders of any Material Indebtedness or any
     trustee or agent on its or their behalf to cause any Material Indebtedness
     to become due, or to require the prepayment, repurchase, redemption or
     defeasance thereof, prior to its scheduled maturity; provided that this
                                                          --------          
     clause (h) shall not apply to secured Indebtedness that becomes due as a
     result of the voluntary sale or transfer of the property or assets securing
     such Indebtedness;

          (i) an involuntary proceeding shall be commenced or an involuntary
     petition shall be filed seeking (i) liquidation, reorganization or other
     relief in respect of Catalytica, the Borrower or any Subsidiary or its
     debts, or of a substantial part of its assets, under any Federal, state or
     foreign bankruptcy, insolvency, receivership or similar law now or
     hereafter in effect or (ii) the appointment of a receiver, trustee,
     custodian, sequestrator, conservator or similar official for Catalytica,
     the Borrower or any Subsidiary or for a substantial part of its assets,
     and, in any such case, such proceeding or petition shall continue
     undismissed for 60 days or an order or decree approving or ordering any of
     the foregoing shall be entered;

          (j) Catalytica, the Borrower or any Subsidiary shall (i) voluntarily
     commence any proceeding or file any petition seeking liquidation,
     reorganization or other relief under any Federal, state or foreign
     bankruptcy, insolvency, 
<PAGE>
 
                                                                              66

     receivership or similar law now or hereafter in effect, (ii) consent to the
     institution of, or fail to contest in a timely and appropriate manner, any
     proceeding or petition described in clause (i) of this Article, (iii) apply
     for or consent to the appointment of a receiver, trustee, custodian,
     sequestrator, conservator or similar official for Catalytica, the Borrower
     or any Subsidiary or for a substantial part of its assets, (iv) file an
     answer admitting the material allegations of a petition filed against it in
     any such proceeding, (v) make a general assignment for the benefit of
     creditors or (vi) take any action for the purpose of effecting any of the
     foregoing;

          (k) Catalytica, the Borrower or any Subsidiary shall become unable,
     admit in writing its inability or fail generally to pay its debts as they
     become due;

          (l) one or more judgments for the payment of money in an aggregate
     amount in excess of $5,000,000 shall be rendered against Catalytica, the
     Borrower, any Restricted Subsidiary or any combination thereof and the same
     shall remain undischarged for a period of 30 consecutive days during which
     execution shall not be effectively stayed, or any action shall be legally
     taken by a judgment creditor to attach or levy upon any assets of
     Catalytica, the Borrower or any Restricted Subsidiary to enforce any such
     judgment;

          (m) an ERISA Event shall have occurred that, in the opinion of the
     Required Lenders, when taken together with all other ERISA Events that have
     occurred, could reasonably be expected to result in liability of the
     Borrower and the Restricted Subsidiaries in an aggregate amount exceeding
     (i) $3,000,000 in any year or (ii) $5,000,000 for all periods;

          (n) there shall have been a failure on the part of GWI to undertake a
     "Seller Obligatory Remediation" or to indemnify Catalytica, the Borrower or
     any Restricted Subsidiary for an "Environmental Claim" or "Third Party
     Claim", as those terms are defined in the Asset Purchase Agreement, or to
     conduct any remediation required at the "RFI SWMUs" as that term is defined
     in the Environmental Agreement dated June 22, 1997, between GWI and
     Catalytica (i) which individually or in the aggregate could reasonably be
     expected to result in liability of Catalytica, the Borrower and the
     Restricted Subsidiaries in an aggregate amount exceeding $5,000,000 in any
     year or $10,000,000 for all periods, taking into account the proceeds of
     any insurance coverage actually received by Catalytica, the Borrower or any
     Restricted Subsidiary or the amount of any such liability for which
     coverage has been definitively and unambiguously acknowledged, without
     reservation of rights, by the appropriate insurance carrier and (ii) which
     GWI refuses to or will not correct at the conclusion of the dispute
     resolution procedure set forth in Section 4.7 of the Environmental
     Agreement, or for which GWI refuses to accept responsibility for thirty
     (30) days after the conclusion of the procedure for defense and indemnity
     set forth in Section 12.4(c) of the Asset Purchase Agreement, as
     applicable;

          (o) (i) Any Loan Document shall, at any time, cease to be in full
     force and effect (unless released by the Administrative Agent, at the
     direction of the Required Lenders or as otherwise permitted under this
     Agreement) or shall be declared null and void, or the validity or
     enforceability in any material respect thereof shall be contested by any
     Loan Party or (ii) any Lien purported to be 
<PAGE>
 
                                                                              67

     created under any Security Document shall cease to be a valid and perfected
     Lien on any material amount of Collateral or shall be asserted by any Loan
     Party not to be a valid and perfected Lien on any Collateral, in each case
     with the priority required by the applicable Security Document, except (A)
     as a result of the sale or other disposition of the applicable Collateral
     in a transaction permitted under the Loan Documents or (B) as a result of
     the Administrative Agent's failure to maintain possession of any stock
     certificates, promissory notes or other instruments delivered to it under
     the Pledge Agreement; or

          (p) a Change in Control shall occur;

then, and in every such event (other than an event with respect to the Borrower
described in clause (i) or (j) of this Article), and at any time thereafter
during the continuance of such event, the Administrative Agent shall, at the
request of the Required Lenders, by notice to the Borrower, take either or both
of the following actions, at the same or different times:  (i) terminate the
Commitments, and thereupon the Commitments shall terminate immediately, and (ii)
declare the Loans then outstanding to be due and payable in whole (or in part,
in which case any principal not so declared to be due and payable may thereafter
be declared to be due and payable), and thereupon the principal of the Loans so
declared to be due and payable, together with accrued interest thereon and all
fees and other obligations of the Borrower accrued hereunder, shall become due
and payable immediately, without presentment, demand, protest or other notice of
any kind, all of which are hereby waived by the Borrower; and in case of any
event with respect to the Borrower described in clause (i) or (j) of this
Article, the Commitments shall automatically terminate and the principal of the
Loans then outstanding, together with accrued interest thereon and all fees and
other obligations of the Borrower accrued hereunder, shall automatically become
due and payable, without presentment, demand, protest or other notice of any
kind, all of which are hereby waived by the Borrower.


                                  ARTICLE VIII

                            The Administrative Agent
                            ------------------------

          Each of the Lenders and the Issuing Bank hereby irrevocably appoints
the Administrative Agent as its agent and authorizes the Administrative Agent to
take such actions on its behalf and to exercise such powers as are delegated to
the Administrative Agent by the terms of the Loan Documents, together with such
actions and powers as are reasonably incidental thereto.

          The bank serving as the Administrative Agent hereunder shall have the
same rights and powers in its capacity as a Lender as any other Lender and may
exercise the same as though it were not the Administrative Agent, and such bank
and its Affiliates may accept deposits from, lend money to and generally engage
in any kind of business with Catalytica, the Borrower or any Subsidiary or other
Affiliate thereof as if it were not the Administrative Agent hereunder.

          The Administrative Agent shall not have any duties or obligations
except those expressly set forth in the Loan Documents.  Without limiting the
generality of the foregoing, (a) the Administrative Agent shall not be subject
to any fiduciary or other 
<PAGE>
 
                                                                              68

implied duties, regardless of whether a Default has occurred and is continuing,
(b) the Administrative Agent shall not have any duty to take any discretionary
action or exercise any discretionary powers, except discretionary rights and
powers expressly contemplated by the Loan Documents that the Administrative
Agent is required to exercise in writing by the Required Lenders (or such other
number or percentage of the Lenders as shall be necessary under the
circumstances as provided in Section 9.02), and (c) except as expressly set
forth in the Loan Documents, the Administrative Agent shall not have any duty to
disclose, and shall not be liable for the failure to disclose, any information
relating to Catalytica, the Borrower or any of the Subsidiaries that is
communicated to or obtained by the bank serving as Administrative Agent or any
of its Affiliates in any capacity. The Administrative Agent shall not be liable
for any action taken or not taken by it with the consent or at the request of
the Required Lenders (or such other number or percentage of the Lenders as shall
be necessary under the circumstances as provided in Section 9.02) or in the
absence of its own gross negligence or wilful misconduct. The Administrative
Agent shall be deemed not to have knowledge of any Default unless and until
written notice thereof is given to the Administrative Agent by Catalytica, the
Borrower or a Lender, and the Administrative Agent shall not be responsible for
or have any duty to ascertain or inquire into (i) any statement, warranty or
representation made in or in connection with any Loan Document, (ii) the
contents of any certificate, report or other document delivered thereunder or in
connection therewith, (iii) the performance or observance of any of the
covenants, agreements or other terms or conditions set forth in any Loan
Document, (iv) the validity, enforceability, effectiveness or genuineness of any
Loan Document or any other agreement, instrument or document, or (v) the
satisfaction of any condition set forth in Article IV or elsewhere in any Loan
Document, other than to confirm receipt of items expressly required to be
delivered to the Administrative Agent.

          The Administrative Agent shall be entitled to rely upon, and shall not
incur any liability for relying upon, any notice, request, certificate, consent,
statement, instrument, document or other writing believed by it to be genuine
and to have been signed or sent by the proper Person.  The Administrative Agent
also may rely upon any statement made to it orally or by telephone and believed
by it to be made by the proper Person, and shall not incur any liability for
relying thereon.  The Administrative Agent may consult with legal counsel (who
may be counsel for the Borrower), independent accountants and other experts
selected by it, and shall not be liable for any action taken or not taken by it
in accordance with the advice of any such counsel, accountants or experts.

          The Administrative Agent may perform any and all its duties and
exercise its rights and powers by or through any one or more sub-agents
appointed by the Administrative Agent.  The Administrative Agent and any such
sub-agent may perform any and all its duties and exercise its rights and powers
through their respective Related Parties.  The exculpatory provisions of the
preceding paragraphs shall apply to any such sub-agent and to the Related
Parties of each Administrative Agent and any such sub-agent, and shall apply to
their respective activities in connection with the syndication of the credit
facilities provided for herein as well as activities as Administrative Agent.

          Subject to the appointment and acceptance of a successor
Administrative Agent as provided in this paragraph, the Administrative Agent may
resign at any time by notifying the Lenders, the Issuing Bank and the Borrower.
Upon any such resignation, the Required Lenders shall have the right, with the
approval, unless an Event of Default has occurred or is continuing, of the
Borrower, to appoint a successor.  If no successor 
<PAGE>
 
                                                                              69

shall have been so appointed by the Required Lenders and shall have accepted
such appointment within 30 days after the retiring Administrative Agent gives
notice of its resignation, then the retiring Administrative Agent may, on behalf
of the Lenders and the Issuing Bank, appoint a successor Administrative Agent
that shall be a bank with an office in New York, New York, or an Affiliate of
any such bank. Upon the acceptance of its appointment as Administrative Agent
hereunder by a successor, such successor shall succeed to and become vested with
all the rights, powers, privileges and duties of the retiring Administrative
Agent, and the retiring Administrative Agent shall be discharged from its duties
and obligations hereunder. The fees payable by the Borrower to a successor
Administrative Agent shall be the same as those payable to its predecessor
unless otherwise agreed between the Borrower and such successor. After the
Administrative Agent's resignation hereunder, the provisions of this Article and
Section 9.03 shall continue in effect for the benefit of such retiring
Administrative Agent, its sub-agents and their respective Related Parties in
respect of any actions taken or omitted to be taken by any of them while it was
acting as Administrative Agent.

          Each Lender acknowledges that it has, independently and without
reliance upon the Administrative Agent or any other Lender and based on such
documents and information as it has deemed appropriate, made its own credit
analysis and decision to enter into this Agreement.  Each Lender also
acknowledges that it will, independently and without reliance upon the
Administrative Agent or any other Lender and based on such documents and
information as it shall from time to time deem appropriate, continue to make its
own decisions in taking or not taking action under or based upon this Agreement,
any other Loan Document or related agreement or any document furnished hereunder
or thereunder.


                                   ARTICLE IX

                                 Miscellaneous
                                 -------------

          SECTION 9.01.  Notices.  Except in the case of notices and other
                         --------                                         
communications expressly permitted to be given by telephone, all notices and
other communications provided for herein shall be in writing and shall be
delivered by hand or overnight courier service, mailed by certified or
registered mail or sent by telecopy, as follows:

          (a) if to Catalytica or the Borrower, to it at Catalytica, 430
     Ferguson Drive, Mountain View, California 94043-5272, Attention of Lawrence
     Briscoe (Telecopy No. (650) 968-7129);

          (b) if to the Administrative Agent, to The Chase Manhattan Bank, Loan
     and Agency Services Group, One Chase Manhattan Plaza, 8th Floor, New York,
     New York 10081, Attention of Janet Belden (Telecopy No. (212) 552-5658),
     with a copy to The Chase Manhattan Bank, 270 Park Avenue, New York 10017,
     Attention of Joan Garvin  (Telecopy No. (212) 270-5127);

          (c) if to the Issuing Bank, to The Chase Manhattan Bank, Loan and
     Agency Services Group, One Chase Manhattan Plaza, 8th Floor, New York, New
     York 10081, Attention of Janet Belden (Telecopy No. (212) 552-5658) with 
<PAGE>
 
                                                                              70

     a copy to The Chase Manhattan Bank, 270 Park Avenue, New York, New York
     10017, Attention of Joan Garvin (Telecopy No. (212) 270-5127); and

          (d) if to any other Lender, to it at its address (or telecopy number)
     set forth in its Administrative Questionnaire.

Any party hereto may change its address or telecopy number for notices and other
communications hereunder by notice to the other parties hereto.  All notices and
other communications given to any party hereto in accordance with the provisions
of this Agreement shall be deemed to have been given on the date of receipt.

          SECTION 9.02.  Waivers; Amendments.  (a)  No failure or delay by the
                         --------------------                                 
Administrative Agent, the Issuing Bank or any Lender in exercising any right or
power hereunder or under any other Loan Document shall operate as a waiver
thereof, nor shall any single or partial exercise of any such right or power, or
any abandonment or discontinuance of steps to enforce such a right or power,
preclude any other or further exercise thereof or the exercise of any other
right or power.  The rights and remedies of the Administrative Agent, the
Issuing Bank and the Lenders hereunder and under the other Loan Documents are
cumulative and are not exclusive of any rights or remedies that they would
otherwise have.  No waiver of any provision of any Loan Document or consent to
any departure by any Loan Party therefrom shall in any event be effective unless
the same shall be permitted by paragraph (b) of this Section, and then such
waiver or consent shall be effective only in the specific instance and for the
purpose for which given.  Without limiting the generality of the foregoing, the
making of a Loan or issuance of a Letter of Credit shall not be construed as a
waiver of any Default, regardless of whether the Administrative Agent, any
Lender or the Issuing Bank may have had notice or knowledge of such Default at
the time.

          (b)  Neither this Agreement nor any other Loan Document nor any
provision hereof or thereof may be waived, amended or modified except, in the
case of this Agreement, pursuant to an agreement or agreements in writing
entered into by Catalytica, the Borrower and the Required Lenders or, in the
case of any other Loan Document, pursuant to an agreement or agreements in
writing entered into by the Administrative Agent and the Loan Party or Loan
Parties that are parties thereto, in each case with the consent of the Required
Lenders; provided that no such agreement shall (i) increase the Commitment of
         --------                                                            
any Lender without the written consent of such Lender, (ii) reduce the principal
amount of any Loan or LC Disbursement or reduce the rate of interest thereon, or
reduce any fees payable hereunder, without the written consent of each Lender
affected thereby, (iii) postpone the scheduled date of payment of the principal
amount of any Loan or LC Disbursement, or any interest thereon, or any fees
payable hereunder, or reduce the amount of, waive or excuse any such payment, or
postpone the scheduled date of expiration of any Commitment, without the written
consent of each Lender affected thereby, (iv) change Section 2.17(b) or (c) in a
manner that would alter the pro rata sharing of payments required thereby,
without the written consent of each Lender, (v) change any of the provisions of
this Section or the definition of the term "Required Lenders" or any other
provision of any Loan Document specifying the number or percentage of Lenders
(or Lenders of any Class) required to waive, amend or modify any rights
thereunder or make any determination or grant any consent thereunder, without
the written consent of each Lender (or each Lender of such Class, as the case
may be), (vi) release Catalytica or any Subsidiary Loan Party (other than
<PAGE>
 
                                                                              71

Catalytica Combustion and any of its subsidiaries) from its Guarantee
obligations under the Guarantee Agreement (except as expressly provided in the
Guarantee Agreement), or limit its liability in respect of such Guarantee
obligations, without the prior written consent of each Lender, (vii) release all
or any substantial part of the Collateral (other than Collateral pledged by
Catalytica Combustion or its subsidiaries under the Pledge Agreement) from the
Liens of the Security Documents, without the prior written consent of each
Lender or (viii) change any provisions of any Loan Document in a manner that by
its terms adversely affects the rights in respect of payments due to Lenders
holding Loans of any Class differently than those holding Loans of any other
Class, without the prior written consent of Lenders holding a majority in
interest of the outstanding Loans and unused Commitments of each affected Class;
provided further that (A) no such agreement shall amend, modify or otherwise
- ----------------                                                            
affect the rights or duties of the Administrative Agent or the Issuing Bank
without the prior written consent of the Administrative Agent or the Issuing
Bank, as the case may be, and (B) any waiver, amendment or modification of this
Agreement that by its terms affects the rights or duties under this Agreement of
the Revolving Lenders (but not the Term Loan Lenders) or the Term Loan Lenders
(but not the Revolving Lenders) may be effected by an agreement or agreements in
writing entered into by Catalytica, the Borrower and the requisite percentage in
interest of the affected Class of Lenders.

          SECTION 9.03.  Expenses; Indemnity; Damage Waiver.  (a)  The Borrower
                         -----------------------------------                   
shall pay (i) all reasonable out-of-pocket expenses incurred by the
Administrative Agent and its Affiliates, including the reasonable fees, charges
and disbursements of counsel for the Administrative Agent, in connection with
the syndication of the credit facilities provided for herein, the preparation
and administration of the Loan Documents or any amendments, modifications or
waivers of the provisions thereof (whether or not the transactions contemplated
hereby or thereby shall be consummated), (ii) all reasonable out-of-pocket
expenses incurred by the Issuing Bank in connection with the issuance,
amendment, renewal or extension of any Letter of Credit or any demand for
payment thereunder and (iii) all out-of-pocket expenses incurred by the
Administrative Agent, the Issuing Bank or any Lender, including the fees,
charges and disbursements of any counsel for the Administrative Agent, the
Issuing Bank or any Lender, in connection with the enforcement or protection of
its rights in connection with the Loan Documents, including its rights under
this Section, or in connection with the Loans made or Letters of Credit issued
hereunder, including all such out-of-pocket expenses incurred during any
workout, restructuring or negotiations in respect of such Loans or Letters of
Credit.

          (b)  The Borrower shall indemnify the Administrative Agent, the
Issuing Bank and each Lender, and each Related Party of any of the foregoing
Persons (each such Person being called an "Indemnitee") against, and hold each
                                           ----------                         
Indemnitee harmless from, any and all losses, claims, damages, liabilities and
related expenses, including the fees, charges and disbursements of any counsel
for any Indemnitee, incurred by or asserted against any Indemnitee arising out
of, in connection with, or as a result of (i) the execution or delivery of any
Loan Document or any other agreement or instrument contemplated hereby, the
performance by the parties to the Loan Documents of their respective obligations
thereunder or the consummation of the Transactions or any other transactions
contemplated hereby, (ii) any Loan or Letter of Credit or the use of the
proceeds therefrom (including any refusal by the Issuing Bank to honor a demand
for payment under a Letter of Credit if the documents presented in connection
with such 
<PAGE>
 
                                                                              72

demand do not strictly comply with the terms of such Letter of Credit), (iii)
any actual or alleged presence or Release of Hazardous Materials on, under or
from any Mortgaged Property or any other property currently or formerly owned or
operated by the Borrower or any of the Subsidiaries, or any Environmental
Liability related in any way to the Borrower or any of the Subsidiaries, or (iv)
any actual or prospective claim, litigation, investigation or proceeding
relating to any of the foregoing, whether based on contract, tort or any other
theory and regardless of whether any Indemnitee is a party thereto; provided
                                                                    --------
that such indemnity shall not, as to any Indemnitee, be available to the extent
that such losses, claims, damages, liabilities or related expenses resulted from
the gross negligence or wilful misconduct of such Indemnitee or any Affiliate of
such Indemnitee (or of any officer, director, employee, advisor or agent of such
Indemnitee or any such Indemnitee's Affiliates).

          (c)  To the extent that the Borrower fails to pay any amount required
to be paid by it to the Administrative Agent or the Issuing Bank under paragraph
(a) or (b) of this Section, each Lender severally agrees to pay to the
Administrative Agent or the Issuing Bank, as the case may be, such Lender's pro
rata share (determined as of the time that the applicable unreimbursed expense
or indemnity payment is sought) of such unpaid amount; provided that the
                                                       --------         
unreimbursed expense or indemnified loss, claim, damage, liability or related
expense, as the case may be, was incurred by or asserted against the
Administrative Agent or the Issuing Bank in its capacity as such.  For purposes
hereof, a Lender's "pro rata share" shall be determined based upon its share of
the sum of the total Revolving Exposures, outstanding Term Loans and unused
Commitments at the time.

          (d)  To the extent permitted by applicable law, Catalytica and the
Borrower shall not assert, and each hereby waives, any claim against any
Indemnitee, on any theory of liability, for special, indirect, consequential or
punitive damages (as opposed to direct or actual damages) arising out of, in
connection with, or as a result of, this Agreement or any agreement or
instrument contemplated hereby, the Transactions, any Loan or Letter of Credit
or the use of the proceeds thereof.

          (e)  All amounts due under this Section shall be payable promptly
after written demand therefor.

          SECTION 9.04.  Successors and Assigns.  (a)  The provisions of this
                         -----------------------                             
Agreement shall be binding upon and inure to the benefit of the parties hereto
and their respective successors and assigns permitted hereby (including any
Affiliate of the Issuing Bank that issues any Letter of Credit), except that the
Borrower may not assign or otherwise transfer any of its rights or obligations
hereunder without the prior written consent of each Lender (and any attempted
assignment or transfer by the Borrower without such consent shall be null and
void).  Nothing in this Agreement, expressed or implied, shall be construed to
confer upon any Person (other than the parties hereto, their respective
successors and assigns permitted hereby (including any Affiliate of the Issuing
Bank that issues any Letter of Credit) and, to the extent expressly contemplated
hereby, the Related Parties of each of the Administrative Agent, the Issuing
Bank and the Lenders) any legal or equitable right, remedy or claim under or by
reason of this Agreement.

          (b)  Any Lender may assign to one or more assignees all or a portion
of its rights and obligations under this Agreement (including all or a portion
of its Commitment 
<PAGE>
 
                                                                              73

and the Loans at the time owing to it); provided that (i) except in the case of
                                        --------
an assignment to a Lender or an Affiliate of a Lender, each of the Borrower and
the Administrative Agent (and, in the case of an assignment of all or a portion
of a Revolving Commitment or any Lender's obligations in respect of its LC
Exposure, the Issuing Bank) must give their prior written consent to such
assignment (which consent shall not be unreasonably withheld), (ii) except in
the case of an assignment to a Lender or an Affiliate of a Lender or an
assignment of the entire remaining amount of the assigning Lender's Commitment
or Loans, the amount of the Commitment or Loans of the assigning Lender subject
to each such assignment (determined as of the date the Assignment and Acceptance
with respect to such assignment is delivered to the Administrative Agent) shall
not be less than $5,000,000 unless each of the Borrower and the Administrative
Agent otherwise consent, (iii) each partial assignment shall be made as an
assignment of a proportionate part of all the assigning Lender's rights and
obligations under this Agreement, except that this clause (iii) shall not be
construed to prohibit the assignment of a proportionate part of all the
assigning Lender's rights and obligations in respect of one Class of Commitments
or Loans, (iv) the parties to each assignment shall execute and deliver to the
Administrative Agent an Assignment and Acceptance, together with a processing
and recordation fee of $3,500, provided, however, that the Borrower shall not be
                               --------  -------
required to reimburse any such party for the payment of such fee, and (v) the
assignee, if it shall not be a Lender, shall deliver to the Administrative Agent
an Administrative Questionnaire; and provided further that any consent of the
                                     ----------------
Borrower otherwise required under this paragraph shall not be required if an
Event of Default under clause (i) or (j) of Article VII has occurred and is
continuing. Subject to acceptance and recording thereof pursuant to paragraph
(d) of this Section, from and after the effective date specified in each
Assignment and Acceptance the permitted assignee thereunder shall be a party
hereto and, to the extent of the interest which is permitted to be assigned and
is assigned by such Assignment and Acceptance, have the rights and obligations
of a Lender under this Agreement, and the assigning Lender thereunder shall, to
the extent of the interest so assigned by such Assignment and Acceptance, be
released from its obligations under this Agreement (and, in the case of an
Assignment and Acceptance covering all of the assigning Lender's rights and
obligations under this Agreement, such Lender shall cease to be a party hereto
but shall continue to be entitled to the benefits of Sections 2.14, 2.15, 2.16
and 9.03). Any assignment or transfer by a Lender of rights or obligations under
this Agreement that does not comply with this paragraph shall be treated for
purposes of this Agreement as a sale by such Lender of a participation in such
rights and obligations in accordance with paragraph (e) of this Section.

          (c)  The Administrative Agent, acting for this purpose as an agent of
the Borrower, shall maintain at one of its offices in The City of New York a
copy of each Assignment and Acceptance delivered to it and a register for the
recordation of the names and addresses of the Lenders, and the Commitment of,
and principal amount of the Loans and LC Disbursements owing to, each Lender
pursuant to the terms hereof from time to time (the "Register").  The entries in
                                                     --------                   
the Register shall be conclusive absent manifest error, and Catalytica, the
Borrower, the Administrative Agent, the Issuing Bank and the Lenders may treat
each Person whose name is recorded in the Register pursuant to the terms hereof
as a Lender hereunder for all purposes of this Agreement, notwithstanding notice
to the contrary.  The Register shall be available for inspection by the
Borrower, the Issuing Bank and any Lender, at any reasonable time and from time
to time upon reasonable prior notice.
<PAGE>
 
                                                                              74

          (d)  Upon its receipt of a duly completed Assignment and Acceptance
executed by an assigning Lender and a permitted assignee, the assignee's
completed Administrative Questionnaire (unless the assignee shall already be a
Lender hereunder), the processing and recordation fee referred to in paragraph
(b) of this Section and any written consent to such assignment required by
paragraph (b) of this Section, the Administrative Agent shall accept such
Assignment and Acceptance and record the information contained therein in the
Register.  No assignment shall be effective for purposes of this Agreement
unless it has been recorded in the Register as provided in this paragraph.

          (e)  Any Lender may, without the consent of the Borrower, the
Administrative Agent or the Issuing Bank, sell participations to one or more
banks or other entities (a "Participant") in all or a portion of such Lender's
                            -----------                                       
rights and obligations under this Agreement (including all or a portion of its
Commitment and the Loans owing to it); provided that (i) such Lender's
                                       --------                       
obligations under this Agreement shall remain unchanged, (ii) such Lender shall
remain solely responsible to the other parties hereto for the performance of
such obligations and (iii) Catalytica, the Borrower, the Administrative Agent,
the Issuing Bank and the other Lenders shall continue to deal solely and
directly with such Lender in connection with such Lender's rights and
obligations under this Agreement.  Any agreement or instrument pursuant to which
a Lender sells such a participation shall provide that such Lender shall retain
the sole right to enforce the Loan Documents and to approve any amendment,
modification or waiver of any provision of the Loan Documents; provided that
                                                               --------     
such agreement or instrument may provide that such Lender will not, without the
consent of the Participant, agree to any amendment, modification or waiver
described in the first proviso to Section 9.02(b) that affects such Participant.
Subject to paragraph (f) of this Section, the Borrower agrees that each
Participant shall be entitled to the benefits of Sections 2.14, 2.15 and 2.16 to
the same extent as if it were a Lender and had acquired its interest by
assignment pursuant to paragraph (b) of this Section.  To the extent permitted
by law, each Participant also shall be entitled to the benefits of Section 9.08
as though it were a Lender, provided such Participant agrees to be subject to
Section 2.18(c) as though it were a Lender.

          (f)  A Participant shall not be entitled to receive any greater
payment under Section 2.14 or 2.16 than the applicable Lender would have been
entitled to receive with respect to the participation sold to such Participant,
unless the sale of the participation to such Participant is made with the
Borrower's prior written consent.  A Participant that would be a Foreign Lender
if it were a Lender shall not be entitled to the benefits of Section 2.16 unless
the Borrower is notified of the participation sold to such Participant and such
Participant agrees, for the benefit of the Borrower, to comply with Section
2.16(e) as though it were a Lender.

          (g)  Any Lender may at any time pledge or assign a security interest
in all or any portion of its rights under this Agreement to secure obligations
of such Lender, including any pledge or assignment to secure obligations to a
Federal Reserve Bank, and this Section shall not apply to any such pledge or
assignment of a security interest; provided that no such pledge or assignment of
                                   --------                                     
a security interest shall release a Lender from any of its obligations hereunder
or substitute any such pledgee or assignee for such Lender as a party hereto.
<PAGE>
 
                                                                              75

          SECTION 9.05.  Survival.  All covenants, agreements, representations
                         ---------                                            
and warranties made by the Loan Parties in the Loan Documents and in the
certificates or other instruments delivered in connection with or pursuant to
this Agreement or any other Loan Document shall be considered to have been
relied upon by the other parties hereto and shall survive the execution and
delivery of the Loan Documents and the making of any Loans and issuance of any
Letters of Credit, regardless of any investigation made by any such other party
or on its behalf and notwithstanding that the Administrative Agent, the Issuing
Bank or any Lender may have had notice or knowledge of any Default or incorrect
representation or warranty at the time any credit is extended hereunder, and
shall continue in full force and effect as long as the principal of or any
accrued interest on any Loan or any fee or any other amount payable under this
Agreement is outstanding and unpaid or any Letter of Credit is outstanding and
so long as the Commitments have not expired or terminated.  The provisions of
Sections 2.14, 2.15, 2.16 and 9.03 and Article VIII shall survive and remain in
full force and effect regardless of the consummation of the transactions
contemplated hereby, the repayment of the Loans, the expiration or termination
of the Letters of Credit and the Commitments or the termination of this
Agreement or any provision hereof.

          SECTION 9.06.  Counterparts; Integration; Effectiveness.  This
                         -----------------------------------------      
Agreement may be executed in counterparts (and by different parties hereto on
different counterparts), each of which shall constitute an original, but all of
which when taken together shall constitute a single contract.  This Agreement,
the other Loan Documents and any separate letter agreements with respect to fees
payable to the Administrative Agent constitute the entire contract among the
parties relating to the subject matter hereof and supersede any and all previous
agreements and understandings, oral or written, relating to the subject matter
hereof.  This Agreement shall become effective in accordance with the terms and
conditions of the Effectiveness Agreement, and thereafter shall be binding upon
and inure to the benefit of the parties hereto and their respective successors
and assigns.  Delivery of an executed counterpart of a signature page of this
Agreement by telecopy shall be effective as delivery of a manually executed
counterpart of this Agreement.

          SECTION 9.07.  Severability.  Any provision of this Agreement held to
                         -------------                                         
be invalid, illegal or unenforceable in any jurisdiction shall, as to such
jurisdiction, be ineffective to the extent of such invalidity, illegality or
unenforceability without affecting the validity, legality and enforceability of
the remaining provisions hereof; and the invalidity of a particular provision in
a particular jurisdiction shall not invalidate such provision in any other
jurisdiction.

          SECTION 9.08.  Right of Setoff.  If an Event of Default shall have
                         ----------------                                   
occurred and be continuing, each Lender and each of its Affiliates is hereby
authorized at any time and from time to time, to the fullest extent permitted by
law, to set off and apply any and all deposits (general or special, time or
demand, provisional or final) at any time held and other obligations at any time
owing by such Lender or Affiliate to or for the credit or the account of the
Borrower against any of and all the obligations of the Borrower now or hereafter
existing under this Agreement held by such Lender, irrespective of whether or
not such Lender shall have made any demand under this Agreement and although
such obligations may be unmatured.  The rights of each Lender under this Section
are in addition to other rights and remedies (including other rights of setoff)
that such Lender may have.
<PAGE>
 
                                                                              76

          SECTION 9.09.  Governing Law; Jurisdiction; Consent to Service of
                         --------------------------------------------------
Process.  (a)  This Agreement shall be construed in accordance with and governed
- --------                                                                        
by the law of the State of New York.

          (b)  Each of Catalytica and the Borrower hereby irrevocably and
unconditionally submits, for itself and its property, to the nonexclusive
jurisdiction of the Supreme Court of the State of New York sitting in New York
County and of the United States District Court of the Southern District of New
York, and any appellate court from any thereof, in any action or proceeding
arising out of or relating to any Loan Document, or for recognition or
enforcement of any judgment, and each of the parties hereto hereby irrevocably
and unconditionally agrees that all claims in respect of any such action or
proceeding may be heard and determined in such New York State or, to the extent
permitted by law, in such Federal court.  Each of the parties hereto agrees that
a final judgment in any such action or proceeding shall be conclusive and may be
enforced in other jurisdictions by suit on the judgment or in any other manner
provided by law. Nothing in this Agreement or any other Loan Document shall
affect any right that the Administrative Agent, the Issuing Bank or any Lender
may otherwise have to bring any action or proceeding relating to this Agreement
or any other Loan Document against Catalytica, the Borrower or its properties in
the courts of any jurisdiction.

          (c)  Each of Catalytica and the Borrower hereby irrevocably and
unconditionally waives, to the fullest extent it may legally and effectively do
so, any objection that it may now or hereafter have to the laying of venue of
any suit, action or proceeding arising out of or relating to this Agreement or
any other Loan Document in any court referred to in paragraph (b) of this
Section.  Each of the parties hereto hereby irrevocably waives, to the fullest
extent permitted by law, the defense of an inconvenient forum to the maintenance
of such action or proceeding in any such court.

          (d)  Each party to this Agreement irrevocably consents to service of
process in the manner provided for notices in Section 9.01 (including by
telecopy, provided that written confirmation of any such telecopy shall be
delivered by certified or registered mail following such service of process).
Nothing in this Agreement or any other Loan Document will affect the right of
any party to this Agreement to serve process in any other manner permitted by
law.

          SECTION 9.10.  WAIVER OF JURY TRIAL.  EACH PARTY HERETO HEREBY WAIVES,
                         ---------------------                                  
TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A
TRIAL BY JURY IN ANY LEGAL PROCEEDING DIRECTLY OR INDIRECTLY ARISING OUT OF OR
RELATING TO THIS AGREEMENT, ANY OTHER LOAN DOCUMENT OR THE TRANSACTIONS
CONTEMPLATED HEREBY (WHETHER BASED ON CONTRACT, TORT OR ANY OTHER THEORY).  EACH
PARTY HERETO (A) CERTIFIES THAT NO REPRESENTATIVE, AGENT OR ATTORNEY OF ANY
OTHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PARTY WOULD
NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER AND (B)
ACKNOWLEDGES THAT IT AND THE OTHER PARTIES HERETO HAVE BEEN INDUCED TO ENTER
INTO THIS AGREEMENT BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND
CERTIFICATIONS IN THIS SECTION.
<PAGE>
 
                                                                              77

          SECTION 9.11.  Headings.  Article and Section headings and the Table
                         ---------                                            
of Contents used herein are for convenience of reference only, are not part of
this Agreement and shall not affect the construction of, or be taken into
consideration in interpreting, this Agreement.

          SECTION 9.12.  Confidentiality.  Each of the Administrative Agent, the
                         ----------------                                       
Issuing Bank and the Lenders agrees to maintain the confidentiality of the
Information (as defined below), except that Information may be disclosed (a) to
its and its Affiliates' directors, officers, employees and agents, including
accountants, legal counsel and other advisors (it being understood that the
Persons to whom such disclosure is made will be informed of the confidential
nature of such Information and  agree to keep such Information confidential in
accordance with this Section), (b) to the extent requested by any regulatory
authority, (c) to the extent required by applicable laws or regulations or by
any subpoena or similar legal process, (d) to any other party to this Agreement,
(e) in connection with the exercise of any remedies hereunder or any suit,
action or proceeding relating to this Agreement or any other Loan Document or
the enforcement of rights hereunder or thereunder, (f) subject to an agreement
containing provisions substantially the same as those of this Section, to any
assignee of or Participant in, or any prospective assignee of or Participant in,
any of its rights or obligations under this Agreement, (g) with the consent of
the Borrower or (h) to the extent such Information (i) becomes publicly
available other than as a result of a breach of this Section or (ii) becomes
available to the Administrative Agent, the Issuing Bank or any Lender on a
nonconfidential basis from a source other than Catalytica, the Borrower or any
Subsidiary.  For the purposes of this Section, "Information" means all
                                                -----------           
information received from Catalytica, the Borrower or any Subsidiary relating to
Catalytica, the Borrower or such Subsidiary or its business, other than any such
information that is available to the Administrative Agent, the Issuing Bank or
any Lender on a nonconfidential basis prior to disclosure by Catalytica, the
Borrower or such Subsidiary; provided that, in the case of information received
                             --------                                          
from Catalytica,  the Borrower or any Subsidiary after the date hereof, such
information is clearly identified at the time of delivery as confidential;
                                                                          
provided further that all information received from the Asset Purchase Agreement
- -------- -------                                                                
or Supply Agreement shall be subject to Section 8.6 of the Asset Purchase
Agreement and Section XXII of the Supply Agreement, as applicable.  Any Person
required to maintain the confidentiality of Information as provided in this
Section shall be considered to have complied with its obligation to do so if
such Person has exercised the same degree of care to maintain the
confidentiality of such Information as such Person would accord to its own
confidential information.

          SECTION 9.13.  Interest Rate Limitation.  Notwithstanding anything
                         -------------------------                          
herein to the contrary, if at any time the interest rate applicable to any Loan,
together with all fees, charges and other amounts that are treated as interest
on such Loan under applicable law (collectively the "Charges"), shall exceed the
                                                     -------                    
maximum lawful rate (the "Maximum Rate") that may be contracted for, charged,
                          ------------                                       
taken, received or reserved by the Lender holding such Loan in accordance with
applicable law, the rate of interest payable in respect of such Loan hereunder,
together with all Charges payable in respect thereof, shall be limited to the
Maximum Rate and, to the extent lawful, the interest and Charges that would have
been payable in respect of such Loan but were not payable as a result of the
operation of this Section shall be cumulated and the interest and Charges
payable to such Lender in respect of other Loans or periods shall be increased
(but not above the Maximum Rate therefor) until such cumulated amount, together
with interest thereon at 
<PAGE>
 
                                                                              78

the Federal Funds Effective Rate to the date of repayment, shall have been
received by such Lender.


          IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be duly executed by their respective authorized officers as of the day and year
first above written.


                         CATALYTICA, INC.,

                            by
                              _________________________________________
                              Name:
                              Title:


                         CATALYTICA PHARMACEUTICALS, INC.,

                            by
                              _________________________________________ 
                              Name:
                              Title:


                         THE CHASE MANHATTAN BANK, individually and as
                         Administrative Agent, Collateral Agent, Documentation
                         Agent and Issuing Bank,

                            by
                              _________________________________________ 
                              Name:
                              Title:


                         BANK OF TOKYO-MITSUBISHI TRUST COMPANY,

                            by
                              _________________________________________ 
                              Name:
                              Title:
<PAGE>
 
                                                                              79

                         COOPERATIVE CENTRALE RAIFFEISEN-BOERENLEENBANK B.A.,
                         "RABOBANK NEDERLAND", NEW YORK BRANCH,

                            by
                              _________________________________________ 
                              Name:
                              Title:

                            by
                              _________________________________________ 
                              Name:
                              Title:


                         DRESDNER BANK AG, New York Branch and Grand Cayman
                         Branch,

                            by
                              _________________________________________ 
                              Name:
                              Title:
 
                            by
                              _________________________________________ 
                              Name:
                              Title:


                         FIRST UNION NATIONAL BANK,

                            by
                              _________________________________________ 
                              Name:
                              Title:


                         FLEET NATIONAL BANK,

                            by
                              _________________________________________ 
                              Name:
                              Title:
<PAGE>
 
                                                                              80

                         NATEXIS BANQUE (previously known as Banque Francaise Du
                         Commerce Exterieur),

                            by
                              _________________________________________ 
                              Name:
                              Title:

                            by
                              _________________________________________ 
                              Name:
                              Title:

                         THE BANK OF NOVA SCOTIA,

                            by
                              _________________________________________ 
                              Name:
                              Title:


                         THE INDUSTRIAL BANK OF JAPAN, LIMITED,

                            by
                              _________________________________________ 
                              Name:
                              Title:


                         THE MITSUBISHI TRUST AND BANKING CORPORATION,

                            by
                              _________________________________________ 
                              Name:
                              Title:


                         THE ROYAL BANK OF SCOTLAND PLC,

                            by
                              _________________________________________ 
                              Name:
                              Title:
<PAGE>
 
                                                                              81

                         UNION BANK OF CALIFORNIA, N.A.,

                            by
                              _________________________________________ 
                              Name:
                              Title:

                         WACHOVIA BANK, N.A.,
 
                            by
                              _________________________________________ 
                              Name:
                              Title:

<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<MULTIPLIER> 1,000
       
<S>                             <C>                     <C>
<PERIOD-TYPE>                   3-MOS                   6-MOS
<FISCAL-YEAR-END>                          DEC-31-1998             DEC-31-1998
<PERIOD-START>                             APR-01-1998             JAN-01-1998
<PERIOD-END>                               JUN-30-1998             JUN-30-1998
<CASH>                                               0                  37,330
<SECURITIES>                                         0                  12,001
<RECEIVABLES>                                        0                  20,446
<ALLOWANCES>                                         0                       0
<INVENTORY>                                          0                 100,765
<CURRENT-ASSETS>                                     0                 173,783
<PP&E>                                               0                 178,303
<DEPRECIATION>                                       0                  21,420
<TOTAL-ASSETS>                                       0                 334,007
<CURRENT-LIABILITIES>                                0                  45,782
<BONDS>                                              0                       0
                                0                       0
                                          0                       0
<COMMON>                                             0                      32
<OTHER-SE>                                           0                       0
<TOTAL-LIABILITY-AND-EQUITY>                         0                 334,007
<SALES>                                         93,766                 184,046
<TOTAL-REVENUES>                                96,077                 188,211
<CGS>                                           77,696                 154,808
<TOTAL-COSTS>                                   87,784                 172,159
<OTHER-EXPENSES>                                     0                       0
<LOSS-PROVISION>                                     0                       0
<INTEREST-EXPENSE>                               2,394                   5,019
<INCOME-PRETAX>                                  5,393                  10,281
<INCOME-TAX>                                      (360)                   (997)
<INCOME-CONTINUING>                              5,033                   9,284
<DISCONTINUED>                                       0                       0
<EXTRAORDINARY>                                      0                       0
<CHANGES>                                            0                       0
<NET-INCOME>                                     5,033                   5,033
<EPS-PRIMARY>                                      .09                     .16
<EPS-DILUTED>                                      .08                     .15
        

</TABLE>


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