TECHNE CORP /MN/
10-Q, 1995-11-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                   SECURITIES AND EXCHANGE COMMISSION
                        Washington, D.C.  20549
                                   
                               FORM 10-Q

(X)  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

     For the quarterly period ended September 30, 1995, or

(  ) TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

     For the transition period from __________to___________
                                   
                                   
                          __________________
                                   
                    Commission file number 0-17272
                          __________________


                          TECHNE CORPORATION
        (Exact name of registrant as specified in its charter)


       MINNESOTA                                      41-1427402
(State or other jurisdiction                       (I.R.S. Employer
of incorporation or organization)                  Identification No.)


     614 MCKINLEY PLACE N.E.                         (612) 379-8854
       MINNEAPOLIS, MN       55413          (Registrant's telephone number,
     (Address of principal (Zip Code)             including area code)
      executive offices)



Indicate by check mark whether the registrant (1) has filed all reports 
required to be filed by section 13 or 15(d) of the Securities Exchange Act of 
1934 during the preceding 12 months (or for such shorter period that the 
registrant was required to file such reports), and (2) has been subject to 
such filing requirements for the past 90 days.  Yes  (X)   No  (  )
                                                
At November 1, 1995, 9,429,201 shares of the Company's Common Stock (par 
value $.01) were outstanding.
<PAGE>                                   

                     PART I - FINANCIAL INFORMATION
                                   
                     ITEM 1 - FINANCIAL STATEMENTS
                                   
                   TECHNE CORPORATION & SUBSIDIARIES
                      CONSOLIDATED BALANCE SHEETS
                              (Unaudited)
<TABLE>
<CAPTION>                                   
ASSETS                                9/30/95       6/30/95
                                      -------       -------
<S>                                 <C>           <C>    
Cash and cash equivalents           $ 5,984,732   $ 5,317,493
Short-term investments                8,805,790    10,627,730
Accounts receivable (net)             7,854,970     7,385,783
Inventories                           3,369,875     3,265,840
Deferred income taxes                   863,000       813,000
Other current assets                    552,823       396,073
                                    -----------   -----------
  Total current assets               27,431,190    27,805,919
    
Deferred income taxes                   540,000       524,000
Prepaid license fee                     528,000       567,600
Fixed assets (net)                    7,016,368     4,328,429
Intangible assets (net)                 777,451       836,327
                                    -----------   -----------
  TOTAL ASSETS                      $36,293,009   $34,062,275
                                    ===========   ===========
    
LIABILITIES & EQUITY
    
Trade accounts payable              $ 1,821,255   $ 1,548,530
Salary and related accruals             920,001     1,350,650
Other payables                          789,495       662,353
Income taxes payable                  1,154,076       557,447
                                    -----------   -----------
  Total current liabilities           4,684,827     4,118,980
    
Deferred rent                           444,800       423,200
  
Common stock, par value $.01 per
  share; authorized 50,000,000;
  issued and outstanding 9,429,201
  and 9,375,346, respectively            94,292        93,753
Additional paid-in capital            9,391,789     8,546,974
Retained earnings                    21,560,456    20,734,653
Accumulated foreign currency
  translation adjustments               116,845       144,715
                                    -----------   -----------
  Total stockholders' equity         31,163,382    29,520,095
                                    -----------   -----------
  TOTAL LIABILITIES AND
    STOCKHOLDERS' EQUITY            $36,293,009   $34,062,275
                                    ===========   ===========
</TABLE>    
    See notes to unaudited Consolidated Financial Statements.
<PAGE>                                   


                   TECHNE CORPORATION & SUBSIDIARIES
                  CONSOLIDATED STATEMENTS OF EARNINGS
                              (Unaudited)
<TABLE>
<CAPTION>
                                     QUARTER ENDED
                                     -------------
                                  9/30/95       9/30/94
                                  -------       -------
<S>                             <C>           <C>                              
Sales                           $12,794,298   $10,960,794
Cost of sales                     4,663,897     4,455,297
                                -----------   -----------
  Gross margin                    8,130,401     6,505,497
   
Operating expenses:
  Selling, gen. and admin.        3,100,671     2,444,831
  Research and development        2,491,668     1,975,159
  Amortization expense               58,876       114,987
  Interest expense                      224         2,778
  Interest income                  (139,320)      (76,239)
                                -----------   -----------
                                  5,512,119     4,461,516
                                -----------   -----------
Earnings before income taxes      2,618,282     2,043,981
Income taxes                        833,000       606,000
                                -----------   -----------
NET EARNINGS                    $ 1,785,282   $ 1,437,981
                                ===========   ===========

EARNINGS PER COMMON AND
  COMMON EQUIVALENT SHARE       $      0.18   $      0.15
                                ===========   ===========
COMMON AND COMMON EQUIVALENT
  SHARES OUTSTANDING              9,650,445     9,482,124
                                ===========   ===========
</TABLE>

       See notes to unaudited Consolidated Financial Statements.
<PAGE>                                   

                   TECHNE CORPORATION & SUBSIDIARIES
                 CONSOLIDATED STATEMENTS OF CASH FLOWS
                              (Unaudited)
<TABLE>
<CAPTION>
                                                       QUARTER ENDED
                                                       -------------
                                                    9/30/95      9/30/94
                                                    -------      -------
<S>                                              <C>          <C>
CASH FLOWS FROM OPERATING ACTIVITIES
Net earnings                                     $ 1,785,282  $ 1,437,981
Adjustments to reconcile net earnings
 to net cash provided by operating activities:
  Depreciation and amortization                      394,363      431,412
  Deferred income taxes                              (66,000)     (52,000)
  Prepaid license fee                                 39,600            -
  Deferred rent                                       21,600       32,700
  Other                                              101,000            -
  Change in current assets and current
    liabilities:
    (Increase) decrease in:
      Accounts receivable                           (484,946)    (283,564)
      Inventories                                   (113,440)     234,921
      Other current assets                          (163,647)     (31,918)
    Increase (decrease) in:                                       
      Trade account/other payables                   405,602      207,569
      Salary and related accruals                   (428,842)    (392,971)
      Income taxes payable                           598,970      283,000
                                                 -----------  -----------
NET CASH PROVIDED BY OPERATING ACTIVITIES          2,089,542    1,867,130

CASH FLOWS FROM INVESTING ACTIVITIES:
Purchase of short-term investments                (3,243,585)  (3,111,420)
Proceeds from sale of short-term investments       5,065,525    1,515,000
Additions to fixed assets                         (3,043,257)    (172,449)
                                                 -----------  -----------
NET CASH USED BY INVESTING ACTIVITIES             (1,221,317)  (1,768,869)

CASH FLOWS FROM FINANCING ACTIVITIES:
Payments on long term debt                                 -       (9,687)
Issuance of common stock                             143,625       20,949
Repurchase of common stock                          (358,750)           -
                                                 -----------  -----------
NET CASH (USED) PROVIDED BY FINANCING ACTIVITIES    (215,125)      11,262
EFFECT OF EXCHANGE RATE CHANGES ON CASH               14,139       (4,225)
                                                 -----------  -----------
NET CHANGE IN CASH AND EQUIVALENTS                   667,239      105,298
CASH AND EQUIVALENTS AT BEGINNING OF PERIOD        5,317,493    5,878,346
                                                 -----------  -----------
CASH AND EQUIVALENTS AT END OF PERIOD            $ 5,984,732  $ 5,983,644
                                                 ===========  ===========
</TABLE>

       See notes to unaudited Consolidated Financial Statements.
<PAGE>                                   



                   TECHNE CORPORATION & SUBSIDIARIES
              NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                              (Unaudited)

A.   BASIS OF PRESENTATION:

The unaudited Consolidated Financial Statements have been prepared in 
accordance with generally accepted accounting principles and with instructions 
to Form 10-Q and Article 10 of Regulation S-X.   The accompanying unaudited 
Consolidated Financial Statements reflect all adjustments which are, in the 
opinion of management, necessary to a fair presentation of the results for the 
interim periods presented.  All such adjustments are of a normal recurring 
nature.

A summary of significant accounting policies followed by the Company is 
detailed in the Annual Report to Shareholders for Fiscal 1995.  The Company 
follows these policies in preparation of the interim Financial Statements.  
Certain information and footnote disclosures normally included in financial 
statements prepared in accordance with generally accepted accounting 
principles have been condensed or omitted.  It is suggested that the 
Consolidated Financial Statements be read in conjunction with the Company's 
Consolidated Financial Statements and Notes thereto for the fiscal year ended 
June 30, 1995 included in the Company's Annual Report to Shareholders for 
Fiscal 1995.

Certain Consolidated Balance Sheet captions appearing in this interim
report are as follows:

<TABLE>
<CAPTION>
                                                    9/30/95       6/30/95
                                                    -------       -------
<S>                                               <C>           <C>
ACCOUNTS RECEIVABLE
  Accounts receivable                             $ 8,004,970   $ 7,528,783
    Less reserve for bad debts                        150,000       143,000
                                                  -----------   -----------
      NET ACCOUNTS RECEIVABLE                     $ 7,854,970   $ 7,385,783
                                                  ===========   ===========
INVENTORIES
  Raw materials                                   $ 1,840,442   $ 1,743,533
  Work in process                                      39,930        11,964
  Supplies                                            119,405       112,551
  Finished goods                                    1,370,098     1,397,792
                                                  -----------   -----------
      TOTAL INVENTORIES                           $ 3,369,875   $ 3,265,840
                                                  ===========   ===========
FIXED ASSETS
  Laboratory equipment                            $ 7,303,687   $ 6,844,497
  Office equipment                                  2,145,223     2,065,032
  Leasehold improvements                            4,231,286     1,758,724
                                                  -----------   -----------
                                                   13,680,196    10,668,253
    Less accumulated depreciation                                
      and amortization                              6,663,828     6,339,824
                                                  -----------   -----------
      NET FIXED ASSETS                            $ 7,016,368   $ 4,328,429
                                                  ===========   ===========
INTANGIBLE ASSETS
  Customer list                                   $ 1,010,000   $ 1,010,000
  Technology licensing agreements                     500,000       500,000
  Goodwill                                          1,225,547     1,225,547
                                                  -----------   -----------
                                                    2,735,547     2,735,547
    Less accumulated amortization                   1,958,096     1,899,220
                                                  -----------   -----------
      NET INTANGIBLE ASSETS                       $   777,451   $   836,327
                                                  ===========   ===========
</TABLE>











B.  EARNINGS PER SHARE:

Shares used in the earnings per share computations are as follows:

<TABLE>
<CAPTION>
                                                        QUARTER ENDED
                                                        -------------
                                                     9/30/95      9/30/94
                                                     -------      -------
<S>                                                 <C>          <C>
Primary:
Weighted average number of common shares            9,390,975    9,341,864
Dilutive effect of stock options and warrants         259,470      140,260
                                                    ---------    ---------
Average common and common equivalent shares
  outstanding                                       9,650,445    9,482,124
                                                    =========    =========

Fully diluted:
Weighted average number of common shares            9,390,975    9,341,864
Dilutive effect of stock options  and warrants        286,823      142,057
                                                    ---------    ---------
Average common and common equivalent shares
  outstanding                                       9,677,798    9,483,921
                                                    =========    =========

</TABLE>

Fully diluted earnings per share are not separately reported since the
effect of dilution is less than three percent.

                                   
                                   
      ITEM 2 - MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL
                  CONDITION AND RESULTS OF OPERATIONS
                                                               
        Results of Operations Quarter Ended September 30, 1995
                 vs. Quarter Ended September 30, 1994
                 ------------------------------------

Company Structure

Techne Corporation has two operating subsidiaries:  Research and Diagnostic 
Systems, Inc. (R&D Systems) located in Minneapolis, Minnesota and R&D Systems 
Europe Ltd. (R&D Europe) located in Abingdon, England.  R&D Systems has two 
divisions:  Biotechnology and Hematology.  The Biotechnology Division 
manufactures purified cytokines (proteins), antibodies and assay kits which 
are sold primarily to biomedical researchers and clinical research 
laboratories.  The Hematology Division develops and manufactures whole blood 
hematology controls and calibrators which are sold to hospital and clinical 
laboratories to check the performance of their hematology instruments to 
assure the accuracy of hematology test results.  R&D Europe is the distributor 
for R&D Systems' biotechnology products in Europe.  R&D Europe also develops 
and manufactures its own line of biotechnology products and distributes 
products for several other biotechnology companies.  In fiscal 1996, R&D 
Europe opened a sales subsidiary near Frankfurt, Germany.  The Company also 
has a foreign sales corporation, Techne Export Inc.


Net Sales

Net sales for the quarter ended September 30, 1995 were $12,794,298, an 
increase of $1,833,504 (17%) from the quarter ended September 30, 1994.  
R&D Systems sales increased $1,019,774 (13%) and R&D Europe sales increased 
$813,730 (29%) for the quarter ended September 30, 1995, respectively.  
Approximately 60% of R&D Europe sales were from the distribution of R&D 
Systems' products

Approximately 49% of the increase in consolidated sales for the quarter was 
due to the increase in sales of R&D Systems' immunoassay (Quantikine) kits.  
In fiscal 1990, the Biotechnology Division of R&D Systems released its first 
immunoassay kits and currently there are 52 kits on the market.  Sales of 
these kits by R&D Systems and R&D Europe for the quarter ended September 30, 
1995 were $4,959,573 compared to $4,069,435 for the quarter ended September 
30, 1994.

In addition, approximately 10% of the increase in consolidated sales for the 
quarter was due to increased sales of other R&D Systems' products by R&D 
Europe.  Another 10% of the increase in consolidated sales for the quarter 
ended September 30, 1995 was from an increase in sales of R&D Europe in-house 
developed products, mainly proteins produced from biomolecules obtained from 
British Bio-technology Group plc. under the fiscal 1994 Joint Biological 
Research Agreement.  The reacquisition of proficiency survey business by R&D 
Systems' Hematology Division accounted for another 12% increase in 
consolidated sales.  This business had been lost to a competitor in fiscal 
1994, but reacquired in mid-fiscal 1995.

The Company expects similar revenues in the second quarter of fiscal 1996 as 
compared to the first quarter due to the traditional slowing of sales during  
the Thanksgiving through New Year holiday period.  Several new products were 
released in the first quarter and sales of these products, along with products 
planned to be released in the second and third quarters and the normal 
increases after the holiday season, are expected to accelerate revenues to 
record levels in the last half of fiscal 1996.


Gross Margins

Gross margins, as a percentage of sales, increased from the prior year.  
Margins for the first quarter of fiscal 1996 were 63.5% compared to 59.4% for 
the same quarter in fiscal 1995.  

The increase for the quarter was due to an increase in R&D Europe and
Hematology Division gross margins.  R&D Europe gross margins were 51.6% 
compared to 45.6% for the quarter ended September 30, 1994.  This increase in 
R&D Europe gross margins was due to a change in product mix, with increased 
sales of higher margin in-house developed products.  Hematology Division gross 
margins also increased from 33.4% to 39.4% for the quarter ended September 30, 
1995, as a result of changes in the product mix.  R&D Systems' Biotechnology 
Division gross margins increased slightly from 67.5% to 68.6%.


Selling, General and Administrative Expenses

Selling, general and administrative expenses increased $655,839 (27%) from the 
first quarter of fiscal 1995 to the first quarter of fiscal 1996.  The largest 
increase (approximately $439,000) in selling, general and administrative 
expenses for the quarter is attributable to R&D Europe operations.  During the 
first quarter of fiscal 1996 R&D Europe opened a sales subsidiary in Germany 
and costs associated with additional sales staff, travel and start-up costs 
were $126,000 for the quarter.  In addition, $70,000 of the increase in 
selling, general and administrative expenses for the quarter was due to 
additional sales staff added by R&D Europe since the prior year.  Also, during
the first quarter of fiscal 1995, R&D Europe's selling, general and 
administration expenses included an exchange gain of approximately $126,000 
due to the strengthening of the British pound, compared to a minimal exchange 
loss in the first quarter of fiscal 1996.  R&D Systems' selling, general and 
administrative expenses increased $173,000 from the first quarter of fiscal 
1995, mainly due to additional bonus and profit sharing accruals.

Research and Development Expenses

Research and development expenses increased $516,509 (26%) for the quarter 
ended September 30, 1995.  R&D Europe and R&D Systems' research and 
development expenses increased $136,424 and $380,085, respectively for the 
quarter ended September 30, 1995.  The increases related to products currently 
under development, several of which were or are to be released in the first 
half of fiscal 1996, including R&D Europe's new line of molecular biology 
products and R&D Systems' new line of murine immunoassay kits.  The products 
currently under development include both biotechnology and hematology products.
Also included in R&D Systems' research and development expense for the quarter 
ended September 30, 1995 is a $100,000 payment to Cistron Biotechnology, Inc. 
under a Research and Development Agreement signed in fiscal 1995.


Net Earnings

Earnings before income taxes increased $574,301 from $2,043,981 in the first 
quarter of fiscal 1995 to $2,618,282 in the first quarter of fiscal 1996.  The 
increase in earnings before income taxes was mainly due to an increase in 
Biotechnology Division earnings of $384,491 and an increase in Hematology 
Division earnings of $211,230 for the quarter.  The increase in Biotechnology 
Division results was due to increased sales, partially offset by higher 
expenses.  The increase in Hematology earnings from the prior year was the 
result of an increase in sales and gross margins.  R&D Europe earnings before 
income taxes were $10,557 higher than the prior year, with higher sales being
offset by higher expenses.

Income taxes for the quarter ended September 30, 1995 were provided at a rate 
of approximately 32% of consolidated pretax earnings compared to 30% for the 
comparable period in fiscal 1995.  The tax rate increase in fiscal 1996 is a 
result of the expiration of the U.S. credit for research and development 
expenditures.  U.S. federal and state taxes have been reduced due to the 
benefit of the foreign sales corporation.  Foreign income taxes have been 
provided at a rate of 33% which approximates the tax rate in the United 
Kingdom.


                    Liquidity and Capital Resources

At September  30, 1995, cash and cash equivalents and short-term investments 
were $14,790,522 compared to $15,945,223 at June 30, 1995.  The Company has 
been accumulating cash and short-term investments for future expansion 
purposes.  The Company believes it can meet its future cash, working capital 
requirements and capital additions through currently available funds, cash 
generated from operations and maturities of short-term investments.  The 
Company has an unsecured line of credit of $750,000.  The interest rate on 
the line of credit is at prime.


Cash Flows From Operating Activities

The Company generated cash of $2,089,542 from operating activities in the 
first three months of fiscal 1996 compared to $1,867,130 for the first three 
months of fiscal 1995.  The increase was the result of increased net earnings, 
partially offset by increases in accounts receivable and inventories due to 
increased sales.


Cash Flows From Investing Activities

During the three months ended September 30, 1995 and 1994, the Company reduced 
short-term investments $1,821,940 and increased short-term investments 
$1,596,420, respectively. The Company's investment policy is to place excess 
cash in short-term certificates of deposit and low risk tax-exempt government 
bonds.  The objective of this policy is to obtain the highest possible return 
with the lowest risk, while keeping the funds accessible.  The decrease in 
short-term invenstments in the first quarter of fiscal 1996 was used to fund 
capital additions during the quarter.

Capital additions were $3,043,257 for the first three months of fiscal 1996 
compared to $172,449 for the first three months of fiscal 1995.  Included in 
the fiscal 1996 additions was $2,470,000 for partial payment on leasehold 
improvements being made to the 2201 Kennedy building.  The new space will be 
occupied by R&D Systems Biotechnology Division in stages beginning in the 
second quarter and continuing through early fiscal 1997.  The remaining 
additions in fiscal 1996 and the major additions in fiscal 1995 were for 
laboratory and computer equipment.  Total expenditures for capital additions 
relating to leasehold improvements, laboratory and computer equipment planned 
for the remainder of fiscal 1996 are expected to cost approximately $3,400,000 
and are expected to be financed through currently available cash and 
maturities of short-term investments.


Cash Flows From Financing Activities

Cash of $143,625 and $20,949 was received during the three months ended 
September 30, 1995 and 1994, respectively, for the exercise of options for 
26,000 and 11,795 shares of common stock.  During the first three months of 
fiscal 1996 options for 80,000 shares of common stock were exercised in a 
noncash transaction by the surrender of 31,645 shares of the Company's common 
stock with a market value of $601,250.

During the first three months of fiscal 1996, the Company purchased and 
retired 20,500 shares of Company common stock at a market value of $358,750.

The Company has never paid dividends and has no plans to do so in fiscal 1996.


                      PART II - OTHER INFORMATION


ITEM 1 - LEGAL PROCEEDINGS

     None

ITEM 2 - CHANGES IN SECURITIES

     None

ITEM 3 - DEFAULTS UPON SENIOR SECURITIES

     None

ITEM 4 - SUBMISSION OF MATTERS TO VOTE OF SHAREHOLDERS

     (a)  The Annual Meeting of the Registrant's shareholders was held on
          Thursday, October 19, 1995.

     (b)  A proposal to set the number of directors at six was adopted by
          a vote of 7,453,793 in favor with 10,999 shares against, 24,952
          shares abstaining and no shares represented by broker nonvotes.

     (c)  Proxies for the Annual Meeting were solicited pursuant to
          Regulation 14A under the Securities Exchange Act of 1934, there
          was no solicitation in opposition to management's nominees as
          listed in the proxy statement, and all such nominees were
          elected, as follows:

          Nominee                        For            Withheld
          -------                        ---            --------
          Thomas E. Oland             7,390,230           89,914
          Roger C. Lucas              7,160,985          319,159
          Howard V. O'Connell         7,476,120            4,024
          G. Arthur Herbert           7,477,344            2,800
          Randolph C. Steer           7,479,344              800
          Lowell E. Sears             7,475,644            4,500

     (d)  By a vote of 7,086,018 shares in favor, 344,705 opposed, 58,821
          abstaining and no shares represented by broker nonvotes, the
          shareholders approved option grants to outside directors and a
          200,000 share increase in the number of shares reserved for
          issuance under the Company's 1988 Nonqualified Stock Option Plan.

ITEM 5 - OTHER INFORMATION

     None

ITEM 6 - EXHIBITS AND REPORTS ON FORM 8-K

     A.  EXHIBITS

           See exhibit index immediately following signature page.

     B.  REPORTS ON FORM 8-K

           None
                                   

                               SIGNATURE




Pursuant to the requirements of the Securities Exchange Act of 1934,
the Registrant has duly caused this report to be signed on its behalf
by the undersigned thereunto duly authorized.



                                               TECHNE CORPORATION
                                               (Company)




Date:  November 13, 1995                       Thomas E. Oland
                                               --------------------------
                                               Thomas E. Oland
                                               President, Chief Executive
                                                and Financial Officer


                                   
                             EXHIBIT INDEX
                                TO FORM
                                 10-Q
                                   
                          TECHNE CORPORATION
                                   
                                  
  Exhibit
  Number        Description
  --------      -----------

    10.1        Agreement, dated October 27, 1995 for the first amendment
                to a lease agreement between Craig Lyle Limited Partnership
                (Hillcrest Development) and R&D Systems Inc.

    27          Financial Data Schedule




                            AGREEMENT FOR THE
                       FIRST AMENDMENT TO A LEASE

On this 27th day of October, 1995, it is hereby agreed by and between
HILLCREST DEVELOPMENT, a Minnesota limited partnership, as Lessor, and 
R & D SYSTEMS, INC., a Minnesota corporation, as Tenant, that the Lease
Agreement dated July 24, 1992, and letters of Agreement dated April 27, 1993,
June 22, 1993, January 17, 1995, February 17, 1995, June 15, 1995, August 18,
1995 and September 11, 1995, shall be amended as follows:

1.  Section 1.A. "Premises" shall be replaced with the following:

     1.A.  LEASED PREMISES:  Lessor leases to Tenant and Tenant rents from
     Lessor approximately 318,029 (356,682 square feet on or before July 1,
     1999) square feet of rentable space in the 614 McKinley Place Building,
     the 640 McKinley Place Building, the 2201 Kennedy Building, and the new
     construction "in-fills" (in the aggregate hereafter called the Leased 
     Premises or the Premises), located at 614-640 McKinley, and 2201 Kennedy
     Streets NE, Minneapolis, Minnesota 55413 (see exhibit A) (the foregoing
     buildings in the aggregate are hereafter called the "Building").

2.  Section 1.B. "Term" shall be amended as follows:

     1.B.  TERM:  The Lease Term shall be extended from July 1, 1995,
     through December 31, 2011.

3.  Section 1.C. and 1.D. shall be replaced with the following:

     1.C. and 1.D.:  RENTABLE AREA AND NET RENT:  The rentable areas
     leased by Tenant from Lessor are as follows:

     Square ft   Location                          "like kind", "like use"
     ---------   --------                          -----------------------
     84,808      614 McKinley Place                Lab, office
     47,360      640 McKinley Place                Shipping, packaging (1st
                                                     Floor only)
     79,509      2201 Kennedy Lower Level          Storage
     17,965      2201 Kennedy 1st Floor North      Shipping, packaging
     46,240      2201 Kennedy 1st Floor South      Lab, office
     22,267      2201 Kennedy 2nd Floor South      Office
     11,308      South In-fill (new construction)  Office
      5,375      North In-fill (new construction)  Shipping, packaging
      3,197      North In-fill (new construction)  Lab, office
     38,653      2201 Kennedy 2nd Floor North      Lab, office
   

     NET rent shall be as follows:

     614 McKinley (84,808 sq ft):
     July 1, 1995 - December 31, 1995        $5.00 per square foot NET or
                                               $35,336.67 per month NET.
     January 1, 1996 - December 31, 1997     $5.35 per square foot NET or
                                               $37,810.23 per month NET.
     January 1, 1998 - December 31, 1999     $5.51 per square foot NET or
                                               $38,941.01 per month NET.
     January 1, 2000 - December 31, 2001     $5.68 per square foot NET or
                                               $40,142.45 per month NET.
     January 1, 2002 - December 31, 2003     $5.85 per square foot NET or
                                               $41,343.90 per month NET.
     January 1, 2004 - December 31, 2005     $6.03 per square foot NET or
                                               $42,616.02 per month NET.
     January 1, 2006 - December 31, 2007     $6.31 per square foot NET or
                                               $44,594.87 per month NET.
     January 1, 2008 - December 31, 2009     $6.82 per square foot NET or
                                               $48,199.21 per month NET.
     January 1, 2010 - December 31, 2011     $7.37 per square foot NET or
                                               $52,086.25 per month NET.

     640 McKinley (47,360 sq ft):
     July 1, 1995 - December 31, 1995        $4.40 per square foot NET or
                                               $17,365.33 per month NET.
     January 1, 1996 - December 31, 1997     $4.50 per square foot NET or
                                               $17,760.00 per month NET.
     January 1, 1998 - December 31, 1999     $4.65 per square foot NET or
                                               $18,352.00 per month NET.
     January 1, 2000 - December 31, 2001     $4.80 per square foot NET or
                                               $18,944.00 per month NET.
     January 1, 2002 - December 31, 2003     $4.95 per square foot NET or
                                               $19,536.00 per month NET.
     January 1, 2004 - December 31, 2005     $5.10 per square foot NET or
                                               $20,128.00 per month NET.
     January 1, 2006 - December 31, 2007     $5.25 per square foot NET or
                                               $20,720.00 per month NET.
     January 1, 2008 - December 31, 2009     $5.68 per square foot NET or
                                               $22,417.07 per month NET.
     January 1, 2010 - December 31, 2011     $6.15 per square foot NET or
                                               $24,272.00 per month NET.

     2201 Kennedy - Lower Level (79,509 sq ft):
     March 1, 1996 - December 31, 1998       $2.60 per square foot NET or
                                               $17,226.95 per month NET.
     January 1, 1999 - December 31, 2001     $3.25 per square foot NET or
                                               $21,533.69 per month NET.
     January 1, 2002 - December 31, 2004     $3.90 per square foot NET or
                                               $25,840.43 per month NET.
     January 1, 2005 - December 31, 2007     $4.55 per square foot NET or
                                               $30,147.16 per month NET.
     January 1, 2008 - December 31, 2009     $5.20 per square foot NET or
                                               $34,453.90 per month NET.
     January 1, 2010 - December 31, 2011     $5.85 per square foot NET or
                                               $38,760.64 per month NET.
    
     2201 Kennedy - 1st Floor North (17,965 sq ft):
     March 1, 1996 - June 30, 1996           $8.24 per square foot NET or
                                               $12,334.89 per month NET.
     July 1, 1996 - June 30, 1997            $0.78 per square foot NET or
                                               $1,164.09 per month NET.
     July 1, 1997 - December 31, 1997        $4.34 per square foot NET or
                                               $6,495.70 per month NET.
     January 1, 1998 - June 30, 1998         $4.53 per square foot NET or
                                               $6,787.63 per month NET.
     July 1, 1998 - June 30, 1999            $7.38 per square foot NET or
                                               $11,051.66 per month NET.
     July 1, 1999 - December 31, 1999        $7.37 per square foot NET or
                                               $11,032.29 per month NET.
     January 1, 2000 - June 30, 2000         $7.56 per square foot NET or
                                               $11,324.22 per month NET.
     July 1, 2000 - June 30, 2001            $8.76 per square foot NET or
                                               $13,115.70 per month NET.
     July 1, 2001 - December 31, 2001        $6.24 per square foot NET or
                                               $9,341.80 per month NET.
     January 1, 2002 - December 31, 2003     $6.44 per square foot NET or
                                               $9,641.22 per month NET.
     January 1, 2004 - December 31, 2005     $6.63 per square foot NET or
                                               $9,925.66 per month NET.
     January 1, 2006 - December 31, 2007     $6.83 per square foot NET or
                                               $10,225.08 per month NET.
     January 1, 2008 - December 31, 2009     $7.38 per square foot NET or
                                               $11,054.46 per month NET.
     January 1, 2010 - December 31, 2011     $8.00 per square foot NET or
                                               $11,976.67 per month NET.

     2201 Kennedy - 1st Floor South (46,240 sq ft):
     March 1, 1996 - June 30, 1996           $9.34 per square foot NET or
                                               $36,006.62 per month NET.
     July 1, 1996 - June 30, 1997            $1.88 per square foot NET or
                                               $7,254.18 per month NET.
     July 1, 1997 - December 31, 1997        $5.44 per square foot NET or
                                               $20,977.17 per month NET.
     January 1, 1998 - June 30, 1998         $5.65 per square foot NET or
                                               $21,778.67 per month NET.
     July 1, 1998 - June 30, 1999            $8.50 per square foot NET or
                                               $32,753.81 per month NET.
     July 1, 1999 - December 31, 1999        $8.49 per square foot NET or
                                               $32,703.96 per month NET.
     January 1, 2000 - June 30, 2000         $8.71 per square foot NET or
                                               $33,555.55 per month NET.
     July 1, 2000 - June 30, 2001            $9.90 per square foot NET or
                                               $38,166.62 per month NET.
     July 1, 2001 - December 31, 2001        $7.38 per square foot NET or
                                               $28,453.01 per month NET.
     January 1, 2002 - December 31, 2003     $7.61 per square foot NET or
                                              $29,323.87 per month NET.
     January 1, 2004 - December 31, 2005     $7.84 per square foot NET or
                                               $30,206.28 per month NET.
     January 1, 2006 - December 31, 2007     $8.20 per square foot NET or
                                               $31,608.89 per month NET.
     January 1, 2008 - December 31, 2009     $8.87 per square foot NET or
                                               $34,179.00 per month NET.
     January 1, 2010 - December 31, 2011     $9.58 per square foot NET or
                                               $36,918.79 per month NET.

     2201 Kennedy - 2nd Floor South (22,267 sq ft):
     March 1, 1996 - June 30, 1996           $9.34 per square foot NET or
                                               $17,339.09 per month NET.
     July 1, 1996 - June 30, 1997            $1.88 per square foot NET or
                                               $3,493.27 per month NET.
     July 1, 1997 - December 31, 1997        $5.44 per square foot NET or
                                               $10,101.62 per month NET.
     January 1, 1998 - June 30, 1998         $5.65 per square foot NET or
                                               $10,487.58 per month NET.
     July 1, 1998 - June 30, 1999            $8.50 per square foot NET or
                                               $15,772.69 per month NET.
     July 1, 1999 - December 31, 1999        $8.49 per square foot NET or
                                               $15,748.68 per month NET.
     January 1, 2000 - June 30, 2000         $8.71 per square foot NET or
                                               $16,158.77 per month NET.
     July 1, 2000 - June 30, 2001            $9.90 per square foot NET or
                                               $18,379.24 per month NET.
     July 1, 2001 - December 31, 2001        $7.38 per square foot NET or
                                               $13,701.63 per month NET.
     January 1, 2002 - December 31, 2003     $7.61 per square foot NET or
                                               $14,121.00 per month NET.
     January 1, 2004 - December 31, 2005     $7.84 per square foot NET or
                                               $14,545.92 per month NET.
     January 1, 2006 - December 31, 2007     $8.20 per square foot NET or
                                               $15,221.35 per month NET.
     January 1, 2008 - December 31, 2009     $8.87 per square foot NET or
                                               $16,451.60 per month NET.
     January 1, 2010 - December 31, 2011     $9.58 per square foot NET or
                                               $17,778.34 per month NET.

     2201 Kennedy - South In-fill (11,308 sq ft):
     March 1, 1996 - June 30, 1996           $9.34 per square foot NET or
                                               $8,805.42 per month NET.
     July 1, 1996 - June 30, 1997            $1.88 per square foot NET or
                                               $1,774.01 per month NET.
     July 1, 1997 - December 31, 1997        $5.44 per square foot NET or
                                               $5,129.97 per month NET.
     January 1, 1998 - June 30, 1998         $5.65 per square foot NET or
                                               $5,325.98 per month NET.
     July 1, 1998 - June 30, 1999            $8.50 per square foot NET or
                                               $8,009.95 per month NET.
     July 1, 1999 - December 31, 1999        $8.49 per square foot NET or
                                               $7,997.76 per month NET.
     January 1, 2000 - June 30, 2000         $8.71 per square foot NET or
                                               $8,206.01 per month NET.
     July 1, 2000 - June 30, 2001            $9.90 per square foot NET or
                                               $9,333.65 per month NET.
     July 1, 2001 - December 31, 2001        $7.38 per square foot NET or
                                               $6,958.19 per month NET.
     January 1, 2002 - December 31, 2003     $7.61 per square foot NET or
                                               $7,166.45 per month NET.
     January 1, 2004 - December 31, 2005     $7.84 per square foot NET or
                                               $7,386.95 per month NET.
     January 1, 2006 - December 31, 2007     $8.20 per square foot NET or
                                               $7,729.96 per month NET.
     January 1, 2008 - December 31, 2009     $8.87 per square foot NET or
                                               $8,354.73 per month NET.
     January 1, 2010 - December 31, 2011     $9.58 per square foot NET or
                                               $9,028.50 per month NET.

     2201 Kennedy - North In-fill ( 5,375 sq ft):
     March 1, 1996 - June 30, 1996           $8.24 per square foot NET or
                                               $3,690.51 per month NET.
     July 1, 1996 - June 30, 1997            $0.78 per square foot NET or
                                               $348.29 per month NET.
     July 1, 1997 - December 31, 1997        $4.34 per square foot NET or
                                               $1,943.47 per month NET.
     January 1, 1998 - June 30, 1998         $4.53 per square foot NET or
                                               $2,030.81 per month NET.
     July 1, 1998 - June 30, 1999            $7.38 per square foot NET or
                                               $3,306.58 per month NET.
     July 1, 1999 - December 31, 1999        $7.37 per square foot NET or
                                               $3,300.78 per month NET.
     January 1, 2000 - June 30, 2000         $7.56 per square foot NET or
                                               $3,388.13 per month NET.
     July 1, 2000 - June 30, 2001            $8.76 per square foot NET or
                                               $3,924.12 per month NET.
     July 1, 2001 - December 31, 2001        $6.24 per square foot NET or
                                               $2,795.00 per month NET.
     January 1, 2002 - December 31, 2003     $6.44 per square foot NET or
                                              $2,882.34 per month NET.
     January 1, 2004 - December 31, 2005     $6.63 per square foot NET or
                                               $2,969.69 per month NET.
     January 1, 2006 - December 31, 2007     $6.83 per square foot NET or
                                               $3,057.03 per month NET.
     January 1, 2008 - December 31, 2009     $7.38 per square foot NET or
                                               $3,307.42 per month NET.
     January 1, 2010 - December 31, 2011     $8.00 per square foot NET or
                                               $3,581.09 per month NET.
     
     2201 Kennedy - North In-fill ( 3,197 sq ft):
     March 1, 1996 - June 30, 1996           $9.34 per square foot NET or
                                               $2,489.47 per month NET.
     July 1, 1996 - June 30, 1997            $1.88 per square foot NET or
                                               $501.55 per month NET.
     July 1, 1997 - December 31, 1997        $5.44 per square foot NET or
                                               $1,450.35 per month NET.
     January 1, 1998 - June 30, 1998         $5.65 per square foot NET or
                                               $1,505.76 per month NET.
     July 1, 1998 - June 30, 1999            $8.50 per square foot NET or
                                               $2,264.57 per month NET.
     July 1, 1999 - December 31, 1999        $8.49 per square foot NET or
                                               $2,261.13 per month NET.
     January 1, 2000 - June 30, 2000         $8.71 per square foot NET or
                                               $2,320.01 per month NET.
     July 1, 2000 - June 30, 2001            $9.90 per square foot NET or
                                               $2,638.81 per month NET.
     July 1, 2001 - December 31, 2001        $7.38 per square foot NET or
                                               $1,967.22 per month NET.
     January 1, 2002 - December 31, 2003     $7.61 per square foot NET or
                                               $2,026.10 per month NET.
     January 1, 2004 - December 31, 2005     $7.84 per square foot NET or
                                               $2,088.44 per month NET.
     January 1, 2006 - December 31, 2007     $8.20 per square foot NET or
                                               $2,185.42 per month NET.
     January 1, 2008 - December 31, 2009     $8.87 per square foot NET or
                                               $2,362.05 per month NET.
     January 1, 2010 - December 31, 2011     $9.58 per square foot NET or
                                               $2,552.54 per month NET.

     2201 Kennedy - 2nd Floor North (38,653 sq ft):
     July 1, 1999 - December 31, 1999        $8.49 per square foot NET or
                                              $27,337.93 per month NET.
     January 1, 2000 - June 30, 2000         $8.71 per square foot NET or
                                              $28,049.79 per month NET.
     July 1, 2000 - June 30, 2001            $9.90 per square foot NET or
                                              $31,904.29 per month NET.
     July 1, 2001 - December 31, 2001        $7.38 per square foot NET or
                                              $23,784.48 per month NET.
     January 1, 2002 - December 31, 2003     $7.61 per square foot NET or
                                              $24,512.44 per month NET.
     January 1, 2004 - December 31, 2005     $7.84 per square foot NET or
                                              $25,250.07 per month NET.
     January 1, 2006 - December 31, 2007     $8.20 per square foot NET or
                                              $26,422.55 per month NET.
     January 1, 2008 - December 31, 2009     $8.87 per square foot NET or
                                              $28,571.00 per month NET.
     January 1, 2010 - December 31, 2011     $9.58 per square foot NET or
                                              $30,861.20 per month NET.

     Temporary Leased Premises (2201 Kennedy; 1st Floor):

     2201 Kennedy - (22,450 sq ft; 1st Floor):
     July 1, 1995 - December 31, 1995        $0.00 per square foot NET or
                                               $0.00 per month NET.
     January 1, 1996 - March 31, 1996        $2.00 per square foot NET or
                                               $3,741.67 per month NET.

     2201 Kennedy - (5,550 sq ft; 1st Floor):
     July 1, 1995 - December 31, 1995        $4.40 per square foot NET or
                                               $2,035.00 per month NET.
     January 1, 1996 - March 31, 1996        $4.50 per square foot NET or
                                               $2,081.25 per month NET.

4.  The following section shall be added to the Lease Agreement:

     IMPROVEMENTS TO THE LEASED PREMISES:  Lessor shall provide for 2201
     Kennedy and the new construction "in-fills" a finished project
     consisting of Phase I and Phase II as shown in the approved plans and
     specifications with Tenant's share being $5,500,000.00, plus those items
     for which Tenant is solely responsible, including but not limited to
     cabinetry, trade fixtures and installation of the same, D.I. water
     system, venting/exhaust systems, etc., as per the letter dated August 18,
     1995.  Tenant shall pay its $5,500,000.00 share to Lessor in cash as
     follows:

     Installment #1:  On or before September 14, 1995, the sum of 
                      $2,500,000.00.
     Installment #2:  On or before October 9, 1995, the sum of $750,000.00.
     Installment #3:  On or before January 4, 1996, the sum of $750,000.00.
     Installment #4:  On or before July 2, 1996, the sum of $1,500,000.00.

5.  The following section shall be added to the Lease Agreement:

     UPGRADING OF THE LEASED PREMISES:  Tenant may, at its own expense,
     upgrade the "like kind", "like use" areas of the Leased Premises at 2201
     Kennedy and the 1st Floor of 640 McKinley from a "storage" category to 
     either "Shipping-Packaging" or "Lab-Office" category of "like kind",
     "like use".  Also, "Shipping-Packaging" may be upgraded to "Lab-Office"
     category of "like kind", "like use".  Should upgrading occur in any
     space within the Leased Premises, the NET rent for the upgraded areas
     shall be appropriately increased to coincide with the appropriate
     upgrade "like kind", "like use" category's NET rent for the similar use
     at 2201 Kennedy.  The foregoing, however, shall not be construed to
     limit the Parties from agreeing to upgrade any space upon such terms
     and conditions as may be otherwise mutually agreeable including a
     sharing of upgrade expenses and costs.

6.  Section 5.D. "Loss or Damage" shall be replaced with the following:

     5.D.  LOSS OR DAMAGE:  Except as provided in Paragraph 7 (Mutual Release
     of Claim for Insured Loss), Tenant shall hold Lessor harmless from and
     indemnify Lessor against any and all liability, damage, loss and expense
     arising or resulting from the acts or omission of, or caused by Tenant
     and Tenant's employees, agents, contractors, suppliers, guests, invitees,
     licensees, assigns and subtenants in, upon or about the Leased Premises
     or the Building of which the Leased Premises are a part (or the areas
     adjacent thereto), or arising out of or related to the use or occupancy
     of the Leased Premises or the business or activity conducted with
     respect thereto, including injuries to persons or property.  All property
     (goods and merchandise of Tenant and of persons other than Tenant, 
     including Tenant's customers, in or upon the Leased Premises or the 
     Building of which it is a part) shall be kept, stored or maintained at
     the sole risk of Tenant or the Owner of said property including, but not
     limited to, loss from fire, explosion, wind, rain, hail, water leakage,
     bursting of pipes or conduits, sprinklers, gas, electricity or structural
     failure, regardless of negligence, unless Lessor fails to perform needed
     repairs after reasonable notice or is negligent.  Tenant shall hold
     Lessor harmless from and keep it indemnified against any loss, damage or
     liability arising out  of any claim for loss or damage to the Leased
     Premises.

7.  Section 5.E. "Liability Insurance" shall be replaced with the following:

     5.E.  LIABILITY INSURANCE:  Tenant will keep in force at its own expense
     for so long as this Lease Agreement is in effect, public liability 
     insurance with respect to the Leased Premises in which both Tenant and
     Lessor shall be named as insureds in companies and in a form acceptable
     to Lessor with limits reasonably acceptable to Lessor.  Initially, Lessor
     is agreeable to a minimum combined single limit of Two Million and 
     00/100 Dollars ($2,000,000.00), which can and will be reviewed from time
     to time to comply with accepted industry standards.  Tenant will further
     deposit with Lessor the policies of such insurance or certificates there
     of, or other acceptable evidence that such insurance is in effect, which
     evidence shall provide that Lessor shall be notified in writing thirty
     (30) days prior to cancellation, material change or failure to renew the
     insurance.  If Tenant shall not comply with its covenant made in this
     paragraph Lessor may, at its option, cause such insurance as aforesaid
     to be issued and in such event, Tenant agrees to pay the premium for 
     such insurance promptly upon Lessor's demand.

8.  Section 5.H. "Hazardous Waste" shall be replaced with the following:

     H.  NON-PERMITTED USE:
          1.  Tenant further covenants and  agrees, with respect to any
          "Hazardous Waste" (as that term is defined herein, hereafter
          collectively "Wastes") that it shall not dispose, store, utilize,
          manufacture or produce Wastes, upon the Premises in violation of any
          "Environmental Requirements" or "Environmental Laws" (as those terms
          are defined below).  In all events, evidence that any and all such
          Wastes are being handled, stored, utilized or disposed of in strict
          compliance with all Environmental Requirements and Environmental
          Laws shall be made available to Lessor upon request.  Tenant shall
          immediately upon receipt of a request provide Lessor with copies of
          all permits, inspection reports, monitoring reports, licenses, 
          orders, demands, compliance requests, edicts or other documentation
          filed, served, delivered or transmitted either with, to or from the
          Minnesota Pollution Control Agency, Minnesota Department of Health,
          or the Environmental Protection Agency (or any successor 
          organization) or any other governmental body regulating, controlling
          or dealing with Wastes (hereafter, "Environmental Requirements").
          Tenant further agrees to comply with all Environmental Requirements
          related to Tenant's use of the Building.  In no event shall any 
          Hazardous Wastes be disposed of on the Premises or elsewhere (except
          in a lawful location off site) or through the sewer system serving
          the Premises or stored underground.  Tenant agrees to advise Lessor
          as to what area of the Premises any Wastes or Facility Wastes may 
          be located and/or stored and what construction steps or procedures,
          if any, need to be taken in connection with any construction of the
          Improvements being made to the Premises so as to protect the 
          Premises and surrounding area from contamination from any said 
          Wastes including the prevention of any release into the environment
          as a result of any handling or reasonably foreseeable mishandling of
          said Wastes.  Tenant further agrees to take all appropriate action
          at its sole expense to prevent any release or threatened release on
          to the Premises, including the Land upon which it is situated or the
          surrounding environment as a result of Hazardous Wastes deposited, 
          stored, placed on or which otherwise come to be located upon the
          Premises by Tenant, its agents, employees or invitees or which is
          the result of the existence, emission or release of any Hazardous
          Wastes in, on or from the Premises as a result of the operations or
          possession of the Premises by Tenant.

          2.  "Hazardous Waste" means any "hazardous substances", "pollutants",
          or "contaminants" as those terms are defined in the Comprehensive
          Environmental Response Compensation and Liability Act, 42 U.S.C. 
          9601, et. seq. ("CERCLA") and the Minnesota Environmental Response
          and Liability Act, Minn. Stat. Chapter 115B. ("MERLA"). 
          "Environmental Laws" as used in this Lease Agreement shall mean:
          CERCLA, MERLA, the Toxic Substance Control Act, 15 U.S.C.  2601 et.
          seq., the Resource Conservation and Recovery Act ("RCRA"), 42 U.S.C.
          6901 et. seq. (including the Medical Waste Tracking act of 1988),
          MIWCA, the Clean Air Act, the Clean Water Act and any other federal,
          state or local laws, regulations including but not limited to those
          promulgated by the Food and Drug Administration, or ordinances
          which deal with, regulate or pertain to either Hazardous Waste,
          Facility Waste, oil or petroleum products, whether such laws,
          regulations or ordinances are currently existing, or are hereafter
          amended, adopted, or enacted and whether they are given retroactive
          or prospective effect.

          3.  Upon Lessor's request, Tenant agrees to deliver a copy to Lessor
          of any waste handling contract(s) evidencing compliance with this
          Lease Agreement and Environmental Requirements and Environmental
          Laws.

          4.  Lessor shall have the right from time to time to enter upon and
          investigate the Leased Premises and at its sole option to obtain a
          report from a reputable environmental consultant of Lessor's choice
          as to the presence of any Hazardous Waste (as defined above).  If
          such consultant's report shows that there is a threat of imminent
          release (or there has been a previous release) of Hazardous Waste
          onto the Leased Premises or the surrounding environment within the
          meaning of Environmental Laws or Environmental Requirements, then
          Tenant shall pay for the cost of said report and investigation and
          Lessor shall have the right in its sole discretion to make such
          further investigations on the Leased Premises and procure such
          reports from consultants as Lessor deems necessary, all at the sole
          cost and expense of Tenant.  If such report indicates no threat of
          such imminent release (nor any previous release), then the cost
          therefor shall be borne by Lessor.  Lessor, at the request of
          Tenant, shall request such consultant to agree to keep any research
          processes, trade secrets, or other information which would normally
          be considered confidential in Tenant's trade or industry, and which
          such consultant shall obtain knowledge of through the course of its
          inspections and/or presence upon the Leased Premises, confidential.
          Such consultant shall execute an agreement to evidence such
          undertaking of confidentiality.
     
          5.  If at any time it is determined that Hazardous Wastes are
          present on the Leased Premises and in violation of Environmental
          Requirements or Environmental Laws, and Tenant fails or refuses to
          take timely corrective, remedial, or responsive action, then Lessor
          may, but shall not be deemed required to, take such action.  Any
          such corrective, remedial or responsive action taken in connection
          therewith shall be at Tenant's sole expense, whether such
          corrective, remedial or responsive action is taken by Lessor or
          Tenant; and if taken by Lessor, Tenant shall reimburse Lessor for
          all such costs within ten (10) days of request.  If any corrective,
          remedial or responsive action includes any alterations to the Leased
          Premises or such alterations are required by Environmental
          Requirements or Environmental Laws, said alterations shall be
          performed in compliance with this Lease Agreement.
     
          6.  Tenant shall indemnify and hold harmless Lessor, Lessor's 
          manager, and each of their former, present and future partners,
          officers, directors, employees, agents, shareholders and attorneys,
          and all of their respective successors and assigns, from and against
          any and all liability, loss, cost, damage, and expense, including
          witnesses' and attorneys' fees, resulting from or due to the
          violation of this Section, including the release or threatened 
          release of any Hazardous Waste that was or is claimed or alleged to
          have been deposited, stored, disposed of, placed or otherwise
          located or allowed to be located on the Premises by any person at 
          any time or in connection with the removal or contamination of such
          Hazardous Waste, provided however, this indemnification and hold
          harmless provision shall not be applicable with respect to any
          conditions relating to the Building or underlying land of which it
          is situated, which existed prior to Tenant's taking possession of
          the Premises; nor with respect to actions of Lessor and/or its
          consultants taken upon the Premises after the date Tenant takes
          possession.
     
          7.  Tenant's representations, warranties and obligations under this
          Section shall not be terminated, released, discharged, extinguished
          or otherwise affected by the expiration of the Term or the
          termination or cancellation of this Lease Agreement.  This provision
          may be enforced at any time by Lessor, or its successors and
          assigns or by any of the indemnified parties.

9.  Section 6 "Damage by Fire or Other Casualty" shall be replaced with
     the following:

     6.  DAMAGE BY FIRE OR OTHER CASUALTY:  If all or a part of the Leased
     Premises are made untenantable by fire, explosion or other casualty,
     Lessor may, at its option, elect to terminate this Lease as of the date
     of such damage by written notice to Tenant given within thirty (30) days
     after the casualty.  If Lessor does not so elect to terminate this Lease,
     Lessor shall restore the leased premise to tenantable condition, in which
     event it shall give written notice to Tenant within thirty (30) days
     after the casualty of Lessor's election to restore.  Lessor's restoration
     shall proceed with due diligence, subject to delays from causes beyond
     it's control.  Rent shall be abated during the period that the Leased
     Premises are untenable in proportion to the reduction of tenantability
     during the period of restoration.  If Lessor shall not complete the
     restoration within 100 days in minor cases, but not to exceed 300 days
     in the case of other damage or total destruction, then and thereafter
     this lease may be terminated by either Lessor or Tenant by written
     notice given within 30 days after the expiration of said time period.
     For the purposes of this paragraph, "minor damage" shall mean damages
     costing less than $50,000.00 to repair.

10. Section 7 "Mutual Release of Claim for Insured Loss" shall be replaced
   with the following:

     7.  MUTUAL RELEASE OF CLAIM FOR INSURED LOSS:  Lessor hereby releases
     Tenant from all claims and causes of action for loss or damage to the
     Leased Premises and its fixtures and equipment, and Tenant likewise
     hereby releases Lessor from all claims and causes of action for loss or
     damage to the Leased Premises and to the improvements, fixtures, 
     equipment, merchandise and other personal property in or upon the Leased
     Premises, in each case resulting from fire, explosion or the perils of
     extended coverage, covered by Lessor's fire insurance policy, regardless
     of whether the loss or damage be caused by the acts or omissions of the
     party or its agents or servants.  As to each party, its said release
     shall be in effect for so long as its insurance shall be in effect as
     required by this Lease Agreement.


11. Section 12 "Notice of Tenant's Claim" shall be replaced with the following:

     12.  NOTICE OF TENANT'S CLAIM:  Tenant shall not be entitled to assert
     any action, omission or default of Lessor, (i) without first giving
     notice to Lessor of such act, omission, default, condition or occurrence
     by registered or certified mail sent to Lessor at its office address and
     (ii) without providing Lessor by said notice a reasonable time to remedy
     such action, omission, default or occurrence.

12. Section 15 "Remedies for Tenant's Default" shall be replaced with the
     following:

     15.  REMEDIES FOR TENANT'S DEFAULT:  This Lease is made upon the 
     condition that (a) if Tenant shall neglect or fail to pay any installment
     of rent reserved or any other amount due under this Lease for a period
     of five (5) days after receipt of notice, or (b) if Tenant shall file a
     voluntary petition under the Bankruptcy Code of the United States, as
     amended, in bankruptcy or for a reorganization or arrangement, or under
     Chapter 11 of the Bankruptcy Code, or commence any other court
     proceedings in bankruptcy or insolvency, or for the appointment of a
     receiver or make a general assignment or transfer for the benefit of
     creditor, or vacate or abandon the Leased Premises, or (c) if any
     involuntary bankruptcy proceedings be instituted against Tenant under the
     Bankruptcy Code of the United States, as amended, or if any other
     involuntary bankruptcy or insolvency proceedings is commenced against it
     or if any involuntary proceedings for the appointment of a receiver is
     commenced against it, and further if any such involuntary proceedings
     described in this Paragraph are not dismissed, discharged and terminated
     within thirty (30) days after the commencement thereof, and the status
     quo prior to the commencement of the proceedings restored, or (d) if
     Tenant shall default in the payment and full performance of any covenant,
     condition, or agreement of this Lease to be kept and performed by Tenant
     and such default or breach of performance shall continue for more than
     five (5) days after written notice to Tenant specifying such default or
     breach of performance, then in any of said events, and at any time
     thereafter, Lessor may terminate Tenant's estate and the Lease Term by
     any one of the following methods, that is by notice in writing of such
     termination to Tenant by commencement of any action to recover possession
     of the Leased Premises or any action to terminate, set aside, rescind or
     cancel the Lease, or by re-entry into the Leased Premises and upon the
     happening of any of said events giving Lessor right of termination or in
     the event of termination by Lessor, it may re-enter and take full
     possession of the Leased Premises with due process of law and remove all
     persons and property therefrom, using such force as may be reasonably
     necessary, and Lessor shall not be liable for any damages resulting from
     re-entry and removal of persons and property in or upon the Leased
     Premises and may remove and abandon or otherwise dispose of the same
     without accounting to Tenant, but Lessor shall have the right at its
     option upon re-entry to remove and store personal property found on the
     Leased Premises at Tenant's expense.  Lessor shall have a lien on said
     personal property for expenses of removal and storage incurred, and any
     other sums due under the Lease or as a result of the breach thereof, but
     Lessor shall not be liable for loss or damage of said property suffered
     in removal and storage provided that reasonable care is taken in this
     process.  On termination of the Lease Term and Tenant's estate, Tenant
     shall have no right, title or interest in the Leased Premises or right of
     occupancy thereof.  Notwithstanding a termination of Tenant's estate and
     the Lease Term pursuant to this Paragraph, Tenant shall be and remain 
     liable to Lessor for the payment of the aggregate of the rents and other
     amounts payable under this Lease by Tenant for the balance of the leased
     term, and expenses of re-entry and making the Leased Premises Tenantable,
     and to the extent permitted by law, Lessor, at its option, may accelerate
     the payment of such sums so that the aggregate amount of rent, additional
     rent and all other amounts payable to Lessor by Tenant herein shall be
     immediately due and payable by Tenant to Lessor.   Lessor, after
     re-entry, shall have the right to, but no obligation to, relet the Leased
     Premises, and any rents received by reletting shall be credited first
     against the expenses of re-entry and of making the rents and other amounts
     due under the Lease for the remainder of the Lease Term in chronological
     order, and in no event shall Tenant be entitled to any excess of rent
     received from reletting over rent due under this Lease.  The pursuit of
     any remedy provided herein shall not be a binding election, nor result
     in a waiver of any other right or remedy permitted by law, and any right
     or remedy given under this Lease shall be in addition to and cumulative
     with Lessor's right of action against Tenant for damages for breach of
     the Lease and for recovery of rent and other amounts due under the Lease
     or otherwise permitted by law.  Any exercise or the right of re-entry or
     termination of the Lease Term shall not be a waiver of any right of
     Lessor to recover damages or other amounts against Tenant.  If Tenant
     shall vacate or abandon the Leased Premises prior to the expiration of
     the Lease Term, Lessor shall have no obligation to re-enter or relet the
     Leased Premises and if Lessor shall re-enter the Leased Premises, Lessor
     shall have no duty to relet the Leased Premises in whole or in part.

13. Section 21 "Exculpation" shall be replaced with the following:

     21.  EXCULPATION:  Lessor is a limited partnership ("Partnership")
     organized and existing under the laws of the State of Minnesota. The 
     Tenant agrees that neither the Partnership or general partners or any
     limited partners, nor any officer, director or shareholder thereof shall
     be liable hereunder except to the extent of the Partnership's interest
     in the Building, and Tenant agrees to look solely to the Partnership's
     interest in the Building for the payment of any claim hereunder or for
     the performance hereof.

14. Section 27 "Right of First Refusal - Purchase" shall be replaced
     with the following:

     27.  RIGHT OF FIRST REFUSAL - PURCHASE:  If, during Tenant's occupancy
     of the Leased Premises during the term of this Lease, the Lessor is in
     receipt of a bona fide purchase offer from a third party to purchase the
     Leased Premises ("third party offer"), which offer Lessor decides to 
     accept, Lessor shall give Tenant a copy of the offer along with Lessor's
     written statement that Lessor desires to accept such offer.  Tenant shall
     have the right to purchase the Leased Premises from Lessor upon the same
     terms and conditions as proposed in the third party offer.  Tenant's
     right to purchase the Leased Premises from Lessor may only be exercised
     by Tenant's submission of a written purchase contract properly executed
     by Tenant and delivered to Lessor together with the applicable earnest
     money as above described no later than 7 business days after Lessor has
     provided Tenant with a copy of the third party offer.  If Tenant fails to
     timely submit such a written purchase offer within such 7 business day
     period, Tenant shall be deemed to have waived such purchase right and
     Lessor shall be free to sell the Leased Premises to the third party
     pursuant to the third party offer,  In the case of Tenant not exercising
     such purchase right, Tenant shall, upon the request of Lessor, execute
     a certificate acknowledging that it has waived its rights to purchase the
     Leased Premises pursuant to this paragraph.  Notwithstanding the foregoing
     the rights granted to Tenant under this paragraph 27 shall not be
     applicable in the event Lessor transfers the Leased Premises to family
     members related to any general partner or limited partner of Lessor, to
     related limited partnerships or general partnerships, or to any family
     trusts or related entities; provided, however, that the right of Tenant
     under this paragraph shall continue to be applicable in the event of a
     resale by any such related family transferee to a bona fide third party.

15. The following section shall be added to the Lease Agreement:

     LIMITED OPTION TO PURCHASE THE LEASED PREMISES:  Tenant is hereby granted
     a limited option to purchase the Leased Premises (other than any parking
     leased by Lessor) pursuant only to the terms and conditions of this
     paragraph.  This option may only be exercisable by Tenant by written
     notice to Lessor given after December 31, 1999 and prior to January 1, 
     2005.  Notwithstanding the foregoing, the option may not be exercised by
     Tenant:  (i) in the event Tenant is then in default under this Lease
     Agreement;  (ii) in the event the rights of Tenant to possession of the
     Leased Premises at the time of exercise have been terminated;  (iii) in
     the event Tenant has waived its right of first refusal to purchase the
     property pursuant to Section 27 of the Lease Agreement and the property
     pursuant to such waiver has been sold to a bona fide third party;  or
     (iv) if Tenant has the ability to purchase the property pursuant to
     Section 27 of the Lease Agreement but the time period to purchase under
     Section 27 has not yet expired.  Tenant's exercise of the option shall be
     accomplished by delivering to Lessor an earnest money contract to
     purchase the Leased Premises which earnest money contract shall contain
     the following terms:

     1.  The closing date shall be specified as a date which is not more that
     thirty (30) days from the receipt by Lessor of the earnest money contract;
     
     2.  The purchase price shall be determined by determining the total net
     rent for the Leased Premises for the succeeding twelve (12) month period
     following the closing date had the option not been exercised and dividing
     this sum by a factor equal to nine one-hundredths, five one-thousandths
     (.095);
     
     3.  Tenant's purchase of the Leased Premises shall be on an "as is" basis
     and no representations and warranties regarding the quality of the Leased
     Premises shall be made by Lessor to Tenant;
     
     4.  Real Estate Taxes and installments of special assessments shall be
     prorated between the parties as of the date of closing and Tenant shall
     take subject to all levied and pending special assessments due and
     payable in years subsequent to the year of closing.
     
     5.  Such other terms and conditions as are customarily present in
     an earnest money contract.
     
     6.  A provision allowing Lessor to utilize the tax deferred like kind
     exchange provision under Section 1031 of the Internal Revenue Code and
     requiring the cooperation of Tenant with the same provided that Tenant
     incurs no liability or unreimbursed expense in connection with such
     exchange.

16. Section 30 of the Lease Agreement and the letter dated February 17,
     1995, are hereby amended in their entirety to read as follows:

     PARKING:  Lessor and Tenant agree that Lessor shall provide a minimum of
     375 parking stalls for Tenant over the term of the Lease within a two and
     one-half (2-1/2) block radius, but that the location and number of stalls
     in any given location may vary from time to time as Lessor's transactions
     and ownership may necessitate.  Lessor agrees to use its best efforts to
     provide additional parking stalls if Tenant's needs grow.

17. Sections 1.E., 24, 28, 29, 31, 32, and 33 shall be deemed null and void.

18. Section 34 "General Terms" shall be replaced with the following:

     34.  GENERAL TERMS:  This lease contains all agreements between the
     parties with respect to the Leased Premises and the Buildings of which
     the Leased Premises are a part, and land on which they are situated.  The
     common areas and facilities in and about the Building are not part of
     the Leased Premises and may be varied, expanded or reduced at Lessor's
     election.  This agreement shall not be amended or extended except by
     written agreement signed by both parties.  Square footages shall be based
     upon and reflect the gross construction areas of the Leased Premises. 
     This agreement shall not be amended or extended except by written
     agreement signed by both parties.  The Lease Term shall include the
     original Lease Term and any agreed extension thereof.  The designation
     "Tenant" shall be construed masculine, feminine or neuter as the sense
     shall require, and plural if applicable to more than one party.  The
     obligation of Tenant shall be binding upon all named Tenants, jointly and
     severally, and the terms and conditions shall inure to the benefit and
     be binding upon Tenant and its representatives, successors and assigns,
     subject to the prohibition against assignment and subleasing in
     Paragraph 5(c) above, which is not impaired, and shall inure to the
     benefit and be binding upon Lessor's liability upon assignment under
     this Lease Agreement.  The Lease and its performance shall be governed by
     the laws of Minnesota.  The paragraph headings are for convenience only
     and do not limit, enlarge or construe the text of the Lease, which shall
     govern.  The performance of all of Tenant's covenants shall also be
     conditions to Tenant's continued occupancy and all expressed obligations
     of Tenant shall be Tenant's covenants regardless if so designated. 
     Lessor shall maintain or cause to have maintained the buildings and their
     physical and mechanical systems in good working order including;  HVAC, 
     roof, windows, sewer, plumbing, electrical, lighting (exterior/interior),
     grounds and parking lots.  Lessor shall also provide the necessary or
     requested maintenance staff available during normal working hours and
     on-call 24 hours per day in the case of an emergency.  Maintenance 
     personnel shall also see to routine security items (i.e., checking locked
     doors); however, Tenant assumes all responsibility for its own property
     as provided for in Paragraph 5 (D) herein.  Any notice provided herein
     shall be sufficient if given by registered or certified mail properly
     addressed to the party at the above stated address or such other address
     as it designates in writing, and the date of giving notice shall be the
     date of deposit in the U.S. mail.

Except as herein stated, all terms and conditions of the aforementioned Lease
shall remain in full force and effect.

Tenant:                                 Lessor:

R & D SYSTEMS, INC.,                    HILLCREST DEVELOPMENT,
a Minnesota Corporation                 a Minnesota Limited Partnership

By:  Thomas E. Oland                    By:  Scott M. Tankenoff

Title:  President                       Title:  General Partner
Date:  10/27/95                         Date:  10/27/95

                       GUARANTY OF LEASE AGREEMENT
                                    
     WHEREAS HILLCREST DEVELOPMENT (the "Lessor") has been requested to
enter into an Agreement for the First Amendment to a Lease ("Lease")
with R & D SYSTEMS, INC., a Minnesota corporation ("Tenant") amending an
earlier Lease dated July 24, 1992 and certain letters covering certain
space located at 614-640 McKinley Place, 2201 Kennedy Street NE, Minneapolis,
MN  55413; (hereafter said July 24, 1992 Lease, the Letters, and the Agreement
for the First Amendment to Lease are collectively referred to as the "Lease")
and,

     WHEREAS the Lessor, as a condition to executing the Lease has required
the execution of this Guaranty of Lease Agreement;

     NOW, THEREFORE, the undersigned (hereinafter the "Guarantor"), in
consideration of the premises and other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, hereby agrees as 
follows:

     1.  The Guarantor hereby absolutely, unconditionally guarantees to the 
Lessor the full and prompt payment when due, whether at maturity of all
monetary and non-monetary obligations of Tenant under the Lease and any 
amendments, renewals or substitutions therefore; (said obligations being 
hereinafter called the "Indebtedness"); and the Guarantor agrees to pay all 
costs, expenses and pre-judgment and post-judgment attorneys' fees paid or
incurred by the Lessor in endeavoring to collect the Indebtedness and in 
enforcing this Guaranty.

     2.  Indebtedness of the Tenant under the Lease or otherwise may be
created and continued in any amount without affecting or impairing the
liability of the Guarantor hereunder.

     3.  No act or thing need occur to establish the liability of the
Guarantor hereunder, and with the exception of full payment, no act or thing
(including, but not limited to, a discharge in bankruptcy of the Indebtedness,
and/or the running of the statute of limitations) relating to the Indebtedness
which but for this provision could act as a release of the liabilities of the
Guarantor hereunder, shall in any was exonerate the Guarantor, or affect, 
impair, reduce or release this Guaranty of the liability of the Guarantor 
hereunder; and this shall be a continuing, absolute, unconditional guaranty 
and shall be in force and be binding upon the Guarantor until the Indebtedness
is fully paid.

     4.  The liability of the Guarantor hereunder shall not be affected or 
impaired in any way by any of the following acts or things (which the Lessor 
is hereby expressly authorized to do, omit or suffer from time to time without
notice to or consent of anyone):  (I) any acceptance of collateral security, 
guarantors, accommodation parties or sureties for any or all Indebtedness; 
(ii) any extension or renewal of any Indebtedness (whether or not for longer
than the original period) or any modification of the interest rate, maturity 
or other terms of any Indebtedness; (iii) any waiver or indulgence granted to
the Tenant, any delay or lack of diligence in the enforcement of the 
Indebtedness, or any failure to institute proceedings, file a claim, give any
required notices or otherwise protect any Indebtedness; (iv) any full or 
partial release of, compromise or settlement with, or agreement not to sue, 
the Tenant or any other guarantor or other person liable on any Indebtedness
or the death of any other guarantor or obligor on any Indebtedness; (v) any
release, surrender, cancellation or other discharge of any Indebtedness or
the acceptance of any instrument in renewal or substitution for any 
instrument evidencing Indebtedness; (vi) any failure to obtain collateral 
security (including rights of setoff) for any Indebtedness; (vii) any manner,
order or method of application of any payments or credits on any Indebtedness
or (viii) any adjustment or modification to, or assignment of, the Lease.

     5.  The Guarantor waives any and all defenses, claims, setoffs, and
discharges of the Tenant, or any other obligor, pertaining to the 
Indebtedness, except the defense of discharge by payment in full.  Without
limiting the generality of the foregoing, the Guarantor will not assert 
against the Lessor any defense of waiver, release, discharge in bankruptcy, 
statute of limitations, res judicata, statute of frauds, anti-deficiency 
statute, fraud, ultra vires acts, usury, illegality or unenforceability which
may be available to the Tenant in respect of the Indebtedness, or any setoff
available against the Lessor to the Tenant, whether or not on account of a 
related transaction.  The liability of the Guarantor shall not be affected or 
impaired by any voluntary or involuntary liquidation, dissolution, sale or 
other disposition of all or substantially all the assets, marshaling of assets
and liabilities, receivership, insolvency, bankruptcy, assignment for the
benefit of creditors, reorganization, arrangement, composition or readjustment
of, or other similar event or proceeding affecting, the Tenant or any of its
assets.  The Guarantor will not assert against the Lessor any claim, defense
or setoff available to the Guarantor against the Tenant.

     6.  The Guarantor also hereby waives:  (I) presentment, demand for 
payment, notice of dishonor or nonpayment, and protest of the Indebtedness; 
(ii) notice of the acceptance hereof by the Lessor and of the creation and
existence of all Indebtedness; and (iii) notice of any amendment to or 
modification of any of the terms and provisions of the Lease, or any other 
agreement evidencing any Indebtedness.  The Lessor shall not be required to
resort for payment of the indebtedness from the Tenant or other persons or 
corporations, their properties or estates, or to any collateral, property, 
liens or their rights or remedies whatsoever.

     7.  Whenever, at any time or from time to time, the Guarantor shall make
any payment to the Lessor hereunder, the Guarantor shall notify the Lessor in
writing that such payment is made under this Guaranty for such purpose.  If 
any payment applied by the Lessor to the Indebtedness is thereafter set aside,
recovered, rescinded or required to be returned for any reason (including, 
without limitation, the bankruptcy, insolvency or reorganization of the Tenant
or any other obligor), the Indebtedness to which such payment was applied 
shall for the purpose of this Guaranty be deemed to have continued in 
existence, notwithstanding such application, and this Guaranty shall be 
enforceable as to such Indebtedness as fully as if such application had never
been made.

     8.  No payment by the Guarantor pursuant to any provision hereof shall 
entitle the Guarantor, by subrogation to the rights of the Lessor or otherwise,
to any payment by the Tenant or out of the property of the Tenant until all
of the Indebtedness (including interest) and all costs, expenses and attorneys'
fees paid or incurred by the Lessor in endeavoring to collect the Indebtedness
and enforcing this Guaranty have been fully paid.  The Guarantor will not 
exercise or enforce any right or contribution, reimbursement, recourse or 
subrogation available to the Guarantor as to any Indebtedness, or against any 
person liable therefor, or as to any collateral security therefor, unless and 
until all such Indebtedness shall have been fully paid and discharged.


     9.  This Guaranty shall be binding upon the legal representatives,
successors and assigns of the Guarantor, and shall inure to the benefit of the
successors and assigns of the Lessor.

     10.  If the undersigned consist of more than one person or entity, then
all of the obligations herein shall be deemed the joint and several 
obligations of the undersigned.

     IN WITNESS WHEREOF, the Guarantor has executed this Guaranty as of
this 27th day of October, 1995.
                                               TECHNE CORPORATION

                                               By:  Thomas E. Oland
In the presence of:  Hoff Heiberg


<TABLE> <S> <C>

<ARTICLE> 5
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          JUN-30-1996
<PERIOD-END>                               SEP-30-1995
<CASH>                                       5,984,732
<SECURITIES>                                 8,805,790
<RECEIVABLES>                                8,004,970
<ALLOWANCES>                                   150,000
<INVENTORY>                                  3,369,875
<CURRENT-ASSETS>                            27,431,190
<PP&E>                                      13,680,196
<DEPRECIATION>                               6,663,828
<TOTAL-ASSETS>                              36,293,009
<CURRENT-LIABILITIES>                        4,684,827
<BONDS>                                              0
<COMMON>                                        94,292
                                0
                                          0
<OTHER-SE>                                  31,069,090
<TOTAL-LIABILITY-AND-EQUITY>                36,293,009
<SALES>                                     12,794,298
<TOTAL-REVENUES>                            12,794,298
<CGS>                                        4,663,897
<TOTAL-COSTS>                                4,663,897
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                 224
<INCOME-PRETAX>                              2,618,282
<INCOME-TAX>                                   833,000
<INCOME-CONTINUING>                          1,785,282
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                 1,785,282
<EPS-PRIMARY>                                      .18
<EPS-DILUTED>                                      .18
        

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