TECHNE CORP /MN/
10-Q, 1998-02-12
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                      SECURITIES AND EXCHANGE COMMISSION
                          Washington, D.C.  20549
                                    
                                 FORM 10-Q
                                     
(X)  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934

     For the quarterly period ended December 31, 1997, or

(  ) TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
      EXCHANGE ACT OF 1934

     For the transition period from __________to___________

                            __________________
                                     
                      Commission file number 0-17272
                            __________________


                            TECHNE CORPORATION
          (Exact name of registrant as specified in its charter)

       MINNESOTA                                   41-1427402
(State or other jurisdiction                   (I.R.S. Employer
of incorporation or organization)             Identification No.)


     614 MCKINLEY PLACE N.E.                     (612) 379-8854
     MINNEAPOLIS, MN            55413           (Registrant's telephone
(Address of principal                        number, including area code)
  executive offices)         (Zip Code)


Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by section 13 or 15(d) of the Securities Exchange Act
of 1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to
such filing requirements for the past 90 days.
Yes  (X)   No  (  )

At February 2, 1998, 19,002,483 shares of the Company's Common Stock (par
value $.01) were outstanding.
                                     
                                     
                       PART I - FINANCIAL INFORMATION
                                     
                       ITEM 1 - FINANCIAL STATEMENTS
                                     
                     TECHNE CORPORATION & SUBSIDIARIES
                        CONSOLIDATED BALANCE SHEETS
                                (Unaudited)
    <TABLE>                                 
    <CAPTION>
                                         12/31/97       6/30/97
                                       -----------   -----------
    <S>                                <C>           <C>
    ASSETS
      Cash and cash equivalents        $ 9,900,167   $ 8,598,367
      Short-term investments            22,494,774    16,153,890
      Accounts receivable (net)          8,766,316     9,114,447
      Inventories                        4,013,868     4,087,161
      Deferred income taxes              1,434,000     1,322,000
      Other current assets                 562,718       521,493
                                       -----------   -----------
        Total current assets            47,171,843    39,797,358
    
      Deferred income taxes              1,855,000     1,703,000
      Fixed assets (net)                11,580,624    11,252,741
      Intangible assets (net)              313,177       365,311
      Other assets                         730,613       803,300
                                       -----------   -----------
        TOTAL ASSETS                   $61,651,257   $53,921,710
                                       ===========   ===========
    
    LIABILITIES & EQUITY
      Trade accounts payable           $ 2,492,694   $ 1,609,362
      Salary and related accruals        1,719,824     1,790,035
      Other payables                       262,665       498,873
      Income taxes payable               1,084,174     1,000,096
                                       -----------   -----------
        Total current liabilities        5,559,357     4,898,366
    
      Deferred rent                      1,298,700       942,300
    
      Common stock, par value $.01 per
        share; authorized 50,000,000;
        issued and outstanding
        18,918,878 and 18,875,456,
        respectively                       189,189       188,755
      Additional paid-in capital        13,391,481    12,653,449
      Retained earnings                 40,792,964    34,808,768
      Accumulated foreign currency
        translation adjustments            419,566       430,072
                                       -----------   -----------
        Total stockholders' equity      54,793,200    48,081,044
                                       -----------   -----------
     TOTAL LIABILITIES AND
        STOCKHOLDERS' EQUITY           $61,651,257   $53,921,710
                                       ===========   ===========
     </TABLE>
         See notes to unaudited Consolidated Financial Statements.
                                     
                                     
                                     

                     TECHNE CORPORATION & SUBSIDIARIES
                    CONSOLIDATED STATEMENTS OF EARNINGS
                                (Unaudited)
<TABLE>
<CAPTION>
                                 QUARTER ENDED            SIX MONTHS ENDED
                            ------------------------  ------------------------
                              12/31/97     12/31/96     12/31/97    12/31/96
                            -----------  -----------  -----------  -----------
<S>                         <C>          <C>          <C>          <C> 
SALES                       $15,472,857  $14,409,294  $31,010,000  $28,436,272
Cost of sales                 4,885,856    4,571,712    9,431,762    9,349,842
                            -----------  -----------  -----------  -----------
  Gross margin               10,587,001    9,837,582   21,578,238   19,086,430

Operating expenses 
  (income):
  Selling, general and
    administrative            3,850,195    3,657,534    7,853,599    6,974,769
  Research and development    2,515,658    2,947,251    4,981,506    5,830,095
  Amortization expense            9,663       58,877       52,134      117,754
  Interest expense                    -          441            -       28,524
  Interest income              (286,499)    (164,012)    (530,367)    (322,472)
                            -----------  -----------  -----------  -----------
                              6,089,017    6,500,091   12,356,872   12,628,670
                            -----------  -----------  -----------  -----------
Earnings before 
  income taxes                4,497,984    3,337,491    9,221,366    6,457,760
Income taxes                  1,370,000    1,060,000    2,831,000    2,005,000
                            -----------  -----------  -----------  -----------
NET EARNINGS                $ 3,127,984  $ 2,277,491  $ 6,390,366  $ 4,452,760
                            ===========  ===========  ===========  ===========

BASIC EARNINGS PER SHARE    $      0.17  $      0.12  $      0.34  $      0.23

DILUTED EARNINGS PER SHARE  $      0.16  $      0.12  $      0.33  $      0.23

</TABLE>

         See notes to unaudited Consolidated Financial Statements.
                                     
                                     


                                     
                     TECHNE CORPORATION & SUBSIDIARIES
                   CONSOLIDATED STATEMENTS OF CASH FLOWS
                                (Unaudited)
<TABLE>                                      
<CAPTION>
                                                   SIX MONTHS ENDED
                                              ---------------------------
                                                12/31/97       12/31/96
                                              ------------   ------------
<S>                                           <C>            <C>
CASH FLOWS FROM OPERATING ACTIVITIES:

  Net earnings                                $  6,390,366   $  4,452,760
  Adjustments to reconcile net earnings
    to net cash provided by operating
    activities:
      Depreciation and amortization              1,121,240      1,100,230
      Deferred income taxes                       (273,000)      (483,000)
      Deferred rent                                356,400        159,000
      Tax benefit from exercise of options          44,000              -
      Other                                        273,187         79,200
  Change in current assets and current
    liabilities:
      (Increase) decrease in:
        Accounts receivable                       322,086      1,014,934
        Inventories                                61,271       (335,828)
        Other current assets                      (41,986)       149,967
      Increase (decrease) in:
        Trade account/other payables              650,478       (204,516)
        Salary and related accruals               (68,409)      (167,767)
        Income taxes payable                       91,008        251,793
                                             ------------   ------------
  NET CASH PROVIDED BY OPERATING ACTIVITIES     8,926,641      6,016,773

CASH FLOWS FROM INVESTING ACTIVITIES:

  Purchase of short-term investments          (14,547,334)    (8,385,000)
  Proceeds from sale of
    short-term investments                      8,206,450      7,350,000
  Additions to fixed assets                    (1,648,881)    (3,418,612)
  Proceeds from sale of fixed assets              246,728              -
  Increase in other long term assets                    -       (250,000)
                                             ------------   ------------
  NET CASH USED BY INVESTING ACTIVITIES        (7,743,037)    (4,703,612)

CASH FLOWS FROM FINANCING ACTIVITIES:

  Issuance of common stock                        367,796         25,189
  Repurchase of common stock                     (280,000)    (1,870,827)
                                             ------------   ------------
  NET CASH PROVIDED (USED) BY FINANCING
    ACTIVITIES                                     87,796     (1,845,638)

EFFECT OF EXCHANGE RATE CHANGES ON CASH            30,400         64,274
                                             ------------   ------------
NET CHANGE IN CASH AND EQUIVALENTS              1,301,800       (468,203)
CASH AND EQUIVALENTS AT BEGINNING OF PERIOD     8,598,367      7,422,084
                                             ------------   ------------
CASH AND EQUIVALENTS AT END OF PERIOD        $  9,900,167   $  6,953,881
                                             ============   ============
</TABLE>
        See notes to unaudited Consolidated Financial Statements.
                                     
                                     
                                     
                     TECHNE CORPORATION & SUBSIDIARIES
                NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                (Unaudited)


A.   BASIS OF PRESENTATION:

The unaudited Consolidated Financial Statements have been prepared in
accordance with generally accepted accounting principles and with
instructions to Form 10-Q and Article 10 of Regulation S-X.   The
accompanying unaudited Consolidated Financial Statements reflect all
adjustments which are, in the opinion of management, necessary to a fair
presentation of the results for the interim periods presented.  All such
adjustments are of a normal recurring nature.

A summary of significant accounting policies followed by the Company is
detailed in the Annual Report to Shareholders for Fiscal 1997.  The Company
follows these policies in preparation of the interim Financial Statements.
Certain information and footnote disclosures normally included in financial
statements prepared in accordance with generally accepted accounting
principles have been condensed or omitted.  It is suggested that the
Consolidated Financial Statements be read in conjunction with the Company's
Consolidated Financial Statements and Notes thereto for the fiscal year
ended June 30, 1997 included in the Company's Annual Report to Shareholders
for Fiscal 1997.

Certain Consolidated Balance Sheet captions appearing in this interim
report are as follows:


<TABLE>
<CAPTION>
                                             12/31/97        6/30/97
                                           ------------   ------------
<S>                                        <C>            <C> 
ACCOUNTS RECEIVABLE
  Accounts receivable                      $  8,813,316   $  9,166,447
    Less reserve for bad debts                   47,000         52,000
                                           ------------   ------------
    NET ACCOUNTS RECEIVABLE                $  8,766,316   $  9,114,447
                                           ============   ============

INVENTORIES
  Raw materials                            $  2,086,806   $  2,105,836
  Work in process                                     -         89,100
  Supplies                                      135,328        121,483
  Finished goods                              1,791,734      1,770,742
                                           ------------   ------------
      TOTAL INVENTORIES                    $  4,013,868   $  4,087,161
                                           ============   ============
FIXED ASSETS
  Laboratory equipment                     $  9,529,426   $  9,513,329
  Office equipment                            2,807,903      2,671,947
  Leasehold improvements                      9,782,277      9,063,354
                                           ------------   ------------
                                             22,119,606     21,248,630
    Less accumulated depreciation
      and amortization                       10,538,982      9,995,889
                                           ------------   ------------
      NET FIXED ASSETS                     $ 11,580,624   $ 11,252,741
                                           ============   ============


INTANGIBLE ASSETS
  Customer list                            $  1,010,000   $  1,010,000
  Technology licensing agreements               500,000        500,000
  Goodwill                                    1,225,547      1,225,547
                                           ------------   ------------
                                              2,735,547      2,735,547
    Less accumulated amortization             2,422,370      2,370,236
                                           ------------   ------------
      NET INTANGIBLE ASSETS                $    313,177   $    365,311
                                           ============   ============
</TABLE>

In June 1997, the Financial Accounting Standards Board issued SFAS No. 131,
"Disclosures about Segments of an Enterprise and Related Information,"
which will be effective for the Company beginning July 1, 1998.  SFAS No.
131 redefines how operating segments are determined and requires disclosure
of certain financial and descriptive information about a company's
operating segments.  The Company believes that this statement will not have
a material impact on results reported in its financial statements.

In June 1997, the Financial Accounting Standards Board issued SFAS No. 130,
"Reporting Comprehensive Income," which will be effective for the Company
beginning July 1, 1998.  SFAS No. 130 requires the disclosure of
comprehensive income and its components in the Company's financial
statements.  The Company anticipates the effect of SFAS No. 130 will result
in disclosure of unearned compensation on stock options and foreign
currency translation adjustments on the face of the comprehensive income
statement.


B.  STOCK SPLIT:

On October 23, 1997, the Company declared a two-for-one stock split in the
form of a 100% stock dividend payable to shareholders of record on November
10, 1997.  The payment date for the stock split was November 17, 1997.  All
earnings per share and share amounts included in these financial statements
have been restated to reflect the stock split.


C.  EARNINGS PER SHARE:

Shares used in the earnings per share computations are as follows:

<TABLE>
<CAPTION>
                                    QUARTER ENDED          SIX MONTHS ENDED
                                ----------------------  ----------------------
                                 12/31/97    12/31/96    12/31/97     12/31/96
                                ----------  ----------  ----------  ----------
<S>                             <C>         <C>         <C>         <C>
Weighted average common shares  18,898,817  18,910,196  18,883,475  18,956,764
Dilutive effect of stock
  options and warrants             726,937     532,450     684,750     553,196
                                ----------  ----------  ----------  ----------
Average common and common
  equivalent shares outstanding 19,625,754  19,442,646  19,568,225  19,509,960
                                ==========  ==========  ==========  ==========
</TABLE>

Effective for the quarter ended December 31, 1997, the Company adopted
Statement of Financial Accounting Standards No. 128 (SFAS 128), "Earnings
Per Share".  All prior period earnings per share amounts have been restated
to conform to the new standard.
                                     

                                     
        ITEM 2 - MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL
                    CONDITION AND RESULTS OF OPERATIONS

   Results of Operations Quarter and Six Months Ended December 31, 1997
            vs. Quarter and Six Months Ended December 31, 1996

Techne Corporation has two operating subsidiaries:  Research and Diagnostic
Systems, Inc. (R&D Systems) located in Minneapolis, Minnesota and R&D
Systems Europe Ltd. (R&D Europe) located in Abingdon, England.  R&D Systems
has two divisions:  Biotechnology and Hematology.  The Biotechnology
Division manufactures purified cytokines (proteins), antibodies and assay
kits which are sold primarily to biomedical researchers and clinical
research laboratories.  The Hematology Division develops and manufactures
whole blood hematology controls and calibrators which are sold to hospital
and clinical laboratories to check the performance of their hematology
instruments to assure the accuracy of hematology test results.  R&D Europe
sells R&D Systems' biotechnology products in Europe, both directly and
through a sales subsidiary in Germany.  The Company has a foreign sales
corporation, Techne Export Inc.

In November 1997, Techne purchased $1 million of preferred stock of
ChemoCentryx, Inc. (CCX), representing approximately 16% of issued and
outstanding voting shares.  In addition, Techne is obligated to purchase a
projected $4 million of preferred stock over the next two years upon CCX's
achievement of certain milestones.  After purchase of the additional
preferred shares, Techne will own approximately 49% of the issued and
outstanding voting shares (assuming no investment by other parties).
Techne has consolidated CCX into its financial statements due to the
limited amount of cash consideration provided by the holders of the common
shares of CCX.  CCX is a new technology and drug development company
working in the area of chemokines.  Chemokines are cytokines which regulate
the trafficking patterns of leukocytes, the effector cells of the human
immune system.  In conjunction with the equity investment and joint
research efforts, Techne obtains exclusive worldwide research and
diagnostic marketing rights to chemokine proteins, antibodies and receptors
discovered or developed by CCX or R&D Systems.


Net Sales

Net sales for the quarter ended December 31, 1997 were $15,472,857, an
increase of $1,063,563 (7%) from the quarter ended December 31, 1996.
Sales for the six months ended December 31, 1997 increased $2,573,728 (9%)
from $28,436,272 to $31,010,000.  R&D Systems sales increased $1,414,750
(15%) and $3,191,037 (16%) for the quarter and six months ended December
31, 1997, respectively.  R&D Europe sales decreased $351,187 (7%) and
$617,309 (7%) for the quarter and six months ended December 31, 1997,
respectively.  The decrease in R&D Europe sales was not unexpected due to
the discontinuance of the molecular biology product line.  R&D Europe sales
of continuing product lines increased 25% and 22% from the second quarter
and first six months of last year.

The increase in consolidated sales for the quarter and six months was due,
in part, to increased sales of R&D Systems' cytokines and antibodies.
Sales of cytokines and antibodies by R&D Systems and R&D Europe for the
quarter and six months ended December 31, 1997 were $5,344,896 and
$10,847,122 compared to $4,454,473 and $8,552,995 for the quarter and six
months ended December 31, 1996.

In addition, sales of hematology products increased $335,050 and $840,385
for the quarter and six months ended December 31, 1997, due largely to
increased sales to an OEM customer and the addition of two OEM customers in
fiscal 1998.


Gross Margins

Gross margins, as a percentage of sales, increased from the prior year.
Margins for the second quarter of fiscal 1998 were 68.4% compared to 68.3%
for the same quarter in fiscal 1997.  Margins for the six months ended
December 31, 1997 were 69.6% compared to 67.1% for the same period in
fiscal 1997.

R&D Europe gross margins decreased from 54.0% to 48.6% for the quarter and
from 52.9% to 50.6% for the six months ended December 31, 1997 as a result
of changes in product mix and exchange rates.  Hematology Division gross
margins increased from 41.6% to 42.2% for the quarter and from 40.8% to
45.5% for the six months ended December 31, 1997, also as a result of
changes in product mix.  Biotechnology Division gross margins decreased
slightly from 71.3% to 70.9% for the quarter, but increased from 70.0% to
72.0% for the six months ended December 31, 1997.


Selling, General and Administrative Expenses

Selling, general and administrative expenses increased $192,661 (5%) from
the second quarter of fiscal 1997 to the second quarter of fiscal 1998.
These expenses also increased $878,830 (13%) for the first six months of
fiscal 1998.  The majority of the increase was due to additional occupancy
costs at R&D Systems, plus increased advertising and promotion costs by
both R&D Systems and R&D Europe.  These increased costs were partially
offset by decreased personnel costs at R&D Europe as a result of the
restructuring in the third quarter of fiscal 1997.


Research and Development Expenses

Research and development expenses decreased $431,593 (15%) and $848,589
(15%) for the quarter and six months ended December 31, 1997, respectively.
R&D Europe research and development expenses decreased $706,444 and
$1,338,106 for the quarter and six months, respectively, as a result of a
decrease in payments under the Joint Biological Research Agreement with
British Bio-technology Group, plc. and a decrease in personnel as a result
of the restructuring and the transfer of the majority of research and
development activities to R&D Systems.  R&D Systems' research and
development expenses increased $274,851 and $489,517 for the quarter and
six months ended December 31, 1997, respectively.  The increase related to
products currently under development, many of which have been or will be
released in fiscal 1998.  Products currently under development include both
biotechnology and hematology products.


Net Earnings

Earnings before income taxes increased $1,160,493 from $3,337,491 in the
second quarter of fiscal 1997 to $4,497,984 in the second quarter of fiscal
1998.  Earnings before taxes for the six months increased $2,763,606 from
$6,457,760 to $9,221,366.  The increase in earnings before income taxes was
due mainly to an increase in Biotechnology Division earnings of $746,924
and  $1,565,946 and an increase in Hematology Division earnings of $137,322
and $531,511 for the quarter and six months ended December 31, 1997, as a
result of increased sales and gross margins.  In addition R&D Europe's
earnings before taxes increased $440,000 and $914,292 for the quarter and
six months as a result of the decrease in research and development
expenses.

Income taxes for the quarters and six months ended December 31, 1997 were
provided at a rate of approximately   30% and 31% of consolidated pretax
earnings compared to 32% and 31% for the prior year.  U.S. federal taxes
have been reduced by the credit for research and development expenditures
and the benefit of the foreign sales corporation.  Foreign income taxes
have been provided at rates which approximate the tax rates in the United
Kingdom and Germany.
                                     
                                     
                      Liquidity and Capital Resources

At December 31, 1997, cash and cash equivalents and short-term investments
were $32,394,941 compared to $24,752,257 at June 30, 1997.  The Company has
been accumulating cash and short-term investments for future expansion
purposes.  The Company believes it can meet its future cash, working
capital and capital addition requirements through currently available
funds, cash generated from operations and maturities of short-term
investments.  The Company has an unsecured line of credit of $750,000.  The
interest rate on the line of credit is at prime.  There were no borrowings
on the line in the prior or current fiscal years.


Cash Flows From Operating Activities

The Company generated cash of $8,926,641 from operating activities in the
first six months of fiscal 1998 compared to $6,016,773 for the first six
months of fiscal 1997.  The increase was mainly the result of increased net
earnings and increased current liabilities.


Cash Flows From Investing Activities

During the six months ended December 31, 1997 and 1996, the Company
increased short-term investments $6,340,884 and $1,035,000, respectively.
The Company's investment policy is to place excess cash in short-term tax-
exempt bonds.  The objective of this policy is to obtain the highest
possible return with the lowest risk, while keeping the funds accessible.

Capital additions were $1,648,881 for the first six months of fiscal 1998,
compared to $3,418,612 for the first six months of fiscal 1997.  Included
in the fiscal 1998 and 1997 additions were $721,000 and $2,684,000 for
leasehold improvements related to expansion and remodeling of facilities by
R&D Systems.  The remaining additions in fiscal 1998 and 1997 were for
laboratory and computer equipment.  Total expenditures for capital
additions planned for the remainder of fiscal 1998 are expected to cost
approximately $1.4 million and are expected to be financed through
currently available funds and cash generated from operating activities.


Cash Flows From Financing Activities

Cash of $367,796 and $25,189 was received during the six months ended
December 31, 1997 and 1996, respectively, for the exercise of options for
46,540 and 4,000 shares of common stock.  During the first six months of
fiscal 1998, options for 24,506 shares of common stock were exercised by
the surrender of 7,624 shares of the Company's common stock with a fair
market value of $126,194.

During the first six months of fiscal 1998 and 1997, the Company purchased
and retired 20,000 and 144,600 shares, respectively, of Company common
stock at market values of $280,000 and $1,870,827.  In May 1995, the
Company announced a plan to purchase and retire up to $5,000,000 of its
common stock.  Through February 1, 1997, 437,000 shares have been purchased
at a market value of $4,812,164.  Subject to market conditions and share
price, the Company has extended its stock repurchase program and plans to
purchase and retire up to an additional $5,000,000 of common stock.

During the first six months of fiscal 1998, the Company granted stock
options with a fair value of $200,500 to a non-employee for services
rendered to the Company.

The Company has never paid cash dividends and has no plans to do so in
fiscal 1998.
                                     
                                     
                                     
             ITEM 3 - QUANTITATIVE AND QUALITATIVE DISCLOSURES
                             ABOUT MARKET RISK
                                     
                                     
Not applicable.



                        PART II - OTHER INFORMATION


ITEM 1 - LEGAL PROCEEDINGS

  The Company was sued by Streck Laboratories, Inc. ("Streck") in the
  United States District Court for the District of Nebraska in Omaha on
  November 5, 1997.  Streck alleges in its complaint that the Company
  infringes three patents Streck has obtained on white blood cell
  hematology controls, one of which was issued in November, 1993, and the
  other two in the fall of 1997.  Streck seeks an unspecified amount of
  damages, an injunction prohibiting further infringement, reasonable
  attorneys' fees, and costs.  The Company has answered the complaint,
  denied infringement and asserted counterclaims against Streck seeking to
  have the patents declared invalid and/or not infringed.  The case has
  not entered the formal discovery phase, and it is unlikely it will go to
  trial before 1999.


ITEM 2 - CHANGES IN SECURITIES

  None


ITEM 3 - DEFAULTS UPON SENIOR SECURITIES

  None


ITEM 4 - SUBMISSION OF MATTERS TO VOTE OF SHAREHOLDERS

  Information relating to the Company's Annual Meeting of Shareholders,
  held on October 23, 1997, is contained in the Company's Form 10-Q for
  the quarter ended September 30, 1997, which is incorporated herein by
  reference.


ITEM 5 - OTHER INFORMATION

  Forward Looking Information and Cautionary Statements:  Statements in
  this filing, and elsewhere, which look forward in time involve risks and
  uncertainties which may affect the actual results of operations.  The
  following important factors, among others, have affected and, in the
  future, could affect the Company's actual results:  the introduction and
  acceptance of new biotechnology and hematology products, the levels and
  particular directions of research into cytokines by the Company's
  customers, the impact of the growing number of producers of cytokine
  research products and related price competition, the retention of
  hematology OEM and proficiency survey business, the Company's expansion
  of marketing efforts in Europe, and the costs and results of research
  and product development efforts of the Company and of companies in which
  the Company has invested or with which it has formed strategic
  relationships.
  

ITEM 6 - EXHIBITS AND REPORTS ON FORM 8-K

  A.  EXHIBITS
  
      See exhibit index immediately following signature page.
  
  B.  REPORTS ON FORM 8-K
  
      None
                                     
                                     

                                 SIGNATURE




Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.



                              TECHNE CORPORATION
                              (Company)




Date:  February 13, 1998      Thomas E. Oland
                              ------------------------------
                              Thomas E. Oland
                                 President, Chief Executive and
                                 Financial Officer




                               EXHIBIT INDEX
                                    TO
                                 FORM 10-Q
                                     
                            TECHNE CORPORATION
                                     

     Exhibit #           Description
     ----------          ------------------

          10.1           Investment Agreement between ChemoCentryx, Inc.
                         and Techne Corporation dated November 18, 1997

          27             Financial Data Schedule


                                     


                                  
                            CHEMOCENTRYX, INC.
                                     
                            TECHNE CORPORATION
                                     
                           INVESTMENT AGREEMENT
                                     
                             November 18, 1997
                                

                             TABLE OF CONTENTS

                                                             Page
                                                             ----
1. Definitions                                                  3
     1.1 Specific Definitions                                   3
     1.2 Definitional Provisions                                5

2. Purchase and Sale of Stock                                   6
     2.1 Sale and Purchase of Shares; Grant of Warrants         6
     2.2 Closings                                               6

3. Representations and Warranties by Company                    7
     3.1 Organization, Standing, etc                            7
     3.2 Qualification                                          7
     3.3 Capital Stock                                          7
     3.4 Financial Statements                                   8
     3.5 Title to Properties and Encumbrances                   8
     3.6 Litigation; Governmental Proceedings                   8
     3.7 Compliance with Applicable Laws and Other Instruments  8
     3.8 Preferred Shares, Warrants, Conversion Stock and 
          Warrant Stock                                         8
     3.9 Securities Laws                                        9
     3.10 Patents and Other Intangible Rights                   9
     3.11 Outstanding Debt                                      9
     3.12 Corporate Acts and Proceedings                        9
     3.13 No Brokers or Finders                                10
     3.14 Conflicts of Interest                                10
     3.15 Licenses                                             10
     3.16 Registration Rights                                  10
     3.17 Retirement Plans                                     10
     3.18 Application of Proceeds                              10
     3.19 Disclosure                                           10

4. Representations and Warranties of Investor                  11
     4.1 Investment Intent                                     11
     4.2 Location of Principal Office and Qualification as 
          Accredited Investor                                  11
     4.3 Acts and Proceedings                                  11
     4.4 No Brokers or Finders                                 11
     4.5 Disclosure of Information                             11
     4.6 Investment Experience                                 12
     4.7 Restricted Securities                                 12
     4.8 Further Limitations on Disposition                    12
     4.9 Legends                                               12

5. Conditions of Investor's Obligation                         12
     5.1 Representations and Warranties                        13
     5.2 Compliance with Agreement                             13
     5.3 Additional Financial Statements                       13
     5.4 Certificate of Officers                               13
     5.5 Opinion of Company's Counsel                          13
     5.6 Qualification Under State Securities Laws             16
     5.7 Proceedings and Documents                             17
     5.8 Reservation of Shares for Schall and Others           17
     5.9 Employment Agreement and Proprietary Information and
          Inventions Agreement                                 17
     5.10 Co-Sale Agreement                                    17
     5.11 Research and License Agreement                       17
     5.12 Directors                                            17

6. Affirmative Covenants                                       17
     6.1 Corporate Existence                                   18
     6.2 Books of Account and Reserves                         18
     6.3 Furnishing of Financial Statements and Information    18
     6.4 Inspection                                            20
     6.5 Preparation and Approval of Budgets                   20
     6.6 Payment of Taxes and Maintenance of Properties        20
     6.7 Insurance                                             21
     6.8 Scientific Advisory Committee                         21
     6.9 Directors' and Stockholders' Meetings                 21
     6.10 Replacement of Certificates                          21
     6.11 Application of Proceeds                              22
     6.12 Patents and Other Intangible Rights                  22
     6.13 Rights to Purchase Additional Securities             22
     6.14 Confidentiality Agreements                           23

7. Negative Covenants                                          23
     7.1 Future Registration Rights                            23
     7.2 Other Restrictions                                    23

8. Registration Rights                                         23
     8.1 Required Registration                                 23
     8.2 Incidental Registration                               24
     8.3 Registration Procedures                               25
     8.4 Expenses                                              27
     8.5 Indemnification                                       27

9. Termination of Certain Covenants                            29

10. Miscellaneous                                              29
     10.1 Changes, Waivers, etc                                29
     10.2 Payment of Fees and Expenses                         29
     10.3 Notices                                              29
     10.4 Survival of Representations and Warranties, etc      29
     10.5 Parties in Interest                                  30
     10.6 Headings                                             30
     10.7 Arbitration                                          30
     10.8 Choice of Law                                        30
     10.9 Counterparts                                         30
     
Exhibits
- --------
Exhibit 1A - Amended and Restated Certificate of Incorporation
Exhibit 1B - Bylaws
Exhibit 2 - Form of Warrant
Exhibit 3 - Exceptions
Exhibit 4 - Vesting Agreement
Exhibit 5 - Employment Agreement
Exhibit 6 - Proprietary Information and Inventions Agreement
Exhibit 7 - Co-Sale Agreement
Exhibit 8 - Research and License Agreement


Schedules
- ---------
Schedule A - Subscription/Warrant Obligation
Schedule B - Patent Applications
                                     
                                     

                           INVESTMENT AGREEMENT
                                     

     THIS INVESTMENT AGREEMENT is made and entered into as of the 18th day
of November 1997, by and between ChemoCentryx, Inc., a Delaware corporation
(the "Company") and Techne Corporation, a Minnesota corporation (the
"Investor").

1.   Definitions.

     1.1  Specific Definitions.  As used in this Agreement, the following
terms shall have the meanings set forth or as referenced below:

          "Additional Securities" is defined in Section 6.16.
     
          "Amendment" is defined in Section 2.1.
     
          "Additional Shares of Common Stock" shall mean all shares of
     Common Stock of the Company issued by the Company on or after the
     Closing Date, except the Conversion Stock.
     
          "Closing" is defined in Section 2.2.
     
          "Closing Date" is defined in Section 2.2.
     
          "Commission" shall mean the U.S. Securities and Exchange Commission.
     
          "Common Stock" shall mean the Company's authorized common stock,
     par value $0.001 per share, any additional common shares which may be
     authorized in the future by the Company, and any stock into which such
     common shares may hereafter be changed, and shall also include stock
     of the Company of any other class which is not preferred as to dividends 
     or as to distributions of assets on liquidation, dissolution or winding 
     up of the Company over any other class of stock of the Company, and 
     which is not subject to redemption.
     
          "Company" shall mean ChemoCentryx, Inc., a Delaware corporation.
     
          "Conversion Price" shall mean such price at which the Preferred
     Shares are convertible into Common Stock pursuant to Section 11 hereof
     and the Amendment.
     
          "Convertible Securities" shall mean evidences of indebtedness,
     shares of stock or other securities which are at any time directly or
     indirectly convertible into or exchangeable for Additional Shares of
     Common Stock.
     
          "GAAP" shall mean United States generally accepted accounting
     principles, applied on a consistent basis.
     
          "Indebtedness for Borrowed Money" shall include only indebtedness
     of the Company and its Subsidiaries incurred as the result of a direct
     borrowing of money and shall not include any other indebtedness
     including, but not limited to, indebtedness incurred with respect to
     trade accounts.
     
          "Investor" shall mean Techne Corporation, a Minnesota
     corporation.
     
          "Permitted Liens" shall mean (a) liens for taxes and assessments
     or governmental charges or levies not at the time due or in respect of
     which the validity thereof shall currently be contested in good faith
     by appropriate proceedings; and (b) liens in respect of pledges or
     deposits under worker's compensation laws or similar legislation,
     carriers', warehousemen's, mechanics', laborers' and materialmen's,
     landlord's and statutory and similar liens, if the obligations secured
     by such liens are not then delinquent or are being contested in good
     faith, and liens and encumbrances incidental to the conduct of the
     business of the Company or any Subsidiary which were not incurred in
     connection with the borrowing of money or the obtaining of advances or
     credits and which do not in the aggregate materially detract from the
     value of its property or materially impair the use thereof in the
     operation of its business.
     
          "Preferred Shares" is defined in Section 2.1.
     
          "Public Offering" shall mean a firm underwritten public offering
     of the Company's Common Stock pursuant to a registration filed under
     the Securities Act and through NASD member firms.
     
          "Purchased Stock" shall mean the Preferred Shares, the Conversion
     Stock, the Warrant Stock and the stock or other securities of the
     Company issued in a stock split or reclassification of, or a stock
     dividend or other distribution on or in substitution or exchange for,
     or otherwise in connection with, any of the foregoing securities, or
     in a merger or consolidation involving the Company or a sale of all or
     substantially all of the Company's assets.
     
          "R&D Systems" shall mean Research & Diagnostic Systems, Inc., a
     subsidiary of the Investor.
     
          "Schall" shall mean Dr. Thomas J. Schall.
     
          "Securities" shall mean the Preferred Shares, Warrants, Conversion 
     Stock and Warrant Stock.
     
          "Securities Act" shall mean the Securities Act of 1933, as amended.
     
          "Senior Indebtedness" shall mean (a) the principal of all
     Indebtedness for Borrowed Money of the Company and its Subsidiaries to
     banks, insurance companies or other financial institutions, (b) the
     present value of net minimum lease payments of all leases under which
     the Company or any of its Subsidiaries is the lessee and which are
     required to be capitalized under generally accepted accounting
     principles, (c) the principal of all indebtedness of the Company or
     any of its Subsidiaries under installment purchase agreements, and
     (d) the principal of all indebtedness of the Company or any of its
     Subsidiaries to the owners of any real property leased by the Company
     for leasehold improvements financed by such owners.
     
          "Series A Preferred Stock" shall collectively mean the Company's
     authorized Series A-1, Series A-2, and Series A-3 Preferred Stock, par
     value $0.001 per share, and any stock into which such preferred shares
     may hereafter be changed.
     
          "Subsidiary" shall mean any corporation, association or other
     business entity more than a majority (by number of votes) of the
     voting stock of which is owned or controlled, directly or indirectly,
     by the Company or by one or more of its Subsidiaries or both.
     
          "Warrants" are defined in Section 2.1.
     
          "Warrant Stock" shall mean the shares of Series A Preferred Stock
     issuable upon exercise of the Warrants and all shares of Series A
     Preferred Stock or Common Stock issued in exchange or substitution
     therefor.
     
     1.2  Definitional Provisions.

          (a)  The words "hereof," "herein," and "hereunder" and words of
     similar import, when used in this Agreement, shall refer to this
     Agreement as a whole and not to any particular provisions of this
     Agreement.
     
          (b)  Terms defined in the singular shall have a comparable
     meaning when used in the plural, and vice-versa.
     
          (c)  References to an "Exhibit" or to a "Schedule" are, unless
     otherwise specified, to one of the Exhibits or Schedules attached to
     or referenced in this Agreement, and references to a "Section" or
     "paragraph" are, unless otherwise specified, to one of the Sections or
     paragraphs of this Agreement.
     
          (d)  All accounting terms defined below shall, except as
     otherwise expressly provided, be determined by reference to the
     Company's books of account and in conformity with generally accepted
     accounting principles as applied to such books of account in the
     opinion of the independent certified public accountants selected by
     the Board of Directors of the Company as required under the provisions
     of Section 6.3(b) hereof.
     
          (e)  The term "person" includes any individual, partnership,
     joint venture, corporation, trust, unincorporated organization or
     government or any department or agency thereof.
     
2.   Purchase and Sale of Stock.

     2.1  Sale and Purchase of Shares; Grant of Warrants.  Subject to the
terms and conditions hereof, the Company agrees to sell to the Investor,
and the Investor agrees to purchase from the Company, Series A Preferred
Stock pursuant to and in accordance with the terms of Schedule A to this
Agreement.  The term "Preferred Shares" as used herein shall mean the up to
5,000,000 shares of Series A Stock purchased in accordance with Schedule A
and all shares of the Company issued in a stock split or reclassification
of, or a stock dividend or other distribution on, such Preferred Shares or
in exchange, conversion or substitution therefor.  Furthermore, the Company
agrees to issue to Investor Warrants pursuant to and in accordance with the
terms of Schedule A to this Agreement in the form attached hereto as
Exhibit 2.  The term "Warrants" as used herein shall mean the warrants so
issued.

     2.2  Closings.  The closing of the sales to, and purchases by, the
Investor of the Preferred Shares (the "Closing") and the issuances of the
Warrants shall occur at the offices of Fredrikson & Byron, P.A., 1100
International Centre, 900 Second Avenue South, Minneapolis, Minnesota, at
10:00 A.M., Minneapolis time, within five business days of the later to
occur of the applicable date or attainment of the applicable milestone as
set forth on Schedule A hereto, or on such other day or at such other time
or place as the Investor and the Company shall agree upon (the "Closing
Date").

     At the Closing, the Company will deliver to the Investor certificates
representing the Preferred Shares being purchased by the Investor and the
Warrants to be granted to the Investor, registered in its name, against
delivery to the Company of a check or wire transfer in the amount of the
cash consideration as set forth on Schedule A hereto, in payment of the
total purchase price of the Preferred Shares being purchased by the
Investor.

3.   Representations and Warranties by Company.  Except as discloses in
Exhibit 3 hereto (specifying the Section or Sections making reference to
certain disclosures), the Company represents and warrants to the Investor
that:

     3.1  Organization, Standing, etc.  The Company is a corporation duly
incorporated, validly existing and in good standing under the laws of the
State of Delaware, and has the requisite corporate power and authority to
own its properties and to carry on its business in all material respects as
it is now being conducted.  The Company has the requisite corporate power
and authority to issue the Preferred Shares, the Warrants, the Conversion
Stock and the Warrant Stock, and to otherwise perform its obligations under
this Agreement.  The certified copies of the Amended and Restated
Certificate of Incorporation and Bylaws of the Company, attached as
Exhibits 1A and 1B, respectively, hereto, are true and complete copies of
the duly authorized Amended and Restated Certificate of Incorporation and
Bylaws of the Company in effect as of the date of this Agreement.  The
Company does not have any direct or indirect equity interest in any other
firm, corporation, partnership, joint venture association or other business
organization except as set forth in Exhibit 3 hereto.  If the Company has
any Subsidiary, the representations and warranties set forth in this
Section 3 are being hereby restated with respect to such Subsidiary.

     3.2  Qualification.  The Company is duly qualified or licensed as a
foreign corporation in good standing in each jurisdiction wherein the
nature of its activities or of its properties owned or leased makes such
qualification or licensing necessary and failure to be so qualified or
licensed would have a material adverse impact on its business.

     3.3  Capital Stock.  The authorized capital stock of the Company
consists of 20,000,000 shares of Common Stock (of which 5,143,750 shares
are issued and outstanding as of the date hereof) and 6,666,666 Series A
Preferred Stock (of which no shares are issued and outstanding as of the
date hereof) of which 4,000,000 are designated as Series A-1 Preferred,
1,333,333 are designated as Series A-2 Preferred and 1,333,333 are
designated as Series A-2 Preferred.  The rights and preferences of the
Company's Common Stock and Series A Preferred Stock are as provided in the
Company's Amended and Restated Certificate of Incorporation, a copy of
which is attached hereto as Exhibit 1A (the "Certificate of Incorporation").  
All of the Company's outstanding shares of capital stock were duly authorized 
and validly issued and are fully paid and nonassessable.  There are no 
outstanding subscriptions, options, warrants, calls, contracts, demands, 
commitments, Convertible Securities or other agreements or arrangements of 
any character or nature whatever, except as disclosed in Exhibit 3 hereto or 
as contemplated by this Agreement, under which the Company is or may be 
obligated to issue capital stock or other securities of any kind representing 
an ownership interest or contingent ownership interest in the Company.  Except 
as otherwise disclosed in Exhibit 3 hereto, neither the offer nor the issuance 
or sale of the Securities, constitutes an event, under any anti-dilution 
provisions of any securities issued or issuable by the Company or any 
agreements with respect to the issuance of securities by the Company, which 
will either increase the number of shares issuable pursuant to such provisions 
or decrease the consideration per share to be received by the Company pursuant 
to such provisions.  No holder of any security of the Company is entitled to 
any preemptive or similar rights to purchase securities from the Company which
has not been irrevocably waived, in writing, a copy of which waiver has
been delivered to the Investor; provided, however, that nothing in this
Section 3. shall affect, alter or diminish any right granted to the
Investor in this Agreement.  All outstanding securities of the Company have
been issued in full compliance with an exemption or exemptions from the
registration and prospectus delivery requirements of the Securities Act and
from the registration and qualification requirements of all applicable
state securities laws.

     3.4  Financial Statements.  The Company has delivered to the Investor
an unaudited balance sheet as at October 31, 1997 and a statement of
operations for the period of inception through such date.  Such financial
statements and notes thereto fairly present the financial condition and the
results of operations of the Company, all in accordance with GAAP.

     3.5  Title to Properties and Encumbrances.  The Company has good and
marketable title to all its owned properties and assets, and the properties
and assets used in the conduct of its business, which properties and assets
are not subject to any mortgage, pledge, lease, lien, charge, security
interest, encumbrance or restriction, except (a) those which are shown and
described in Exhibit 4 hereto or the notes thereto, and (b) Permitted Liens.

     3.6  Litigation; Governmental Proceedings.  There are no legal
actions, suits, arbitrations or other legal, administrative or governmental
proceedings or investigations pending or, to the knowledge of the Company,
threatened against the Company, its properties, assets or business, and the
Company is not aware of any facts which are likely to result in or form the
basis for any such action, suit or other proceeding.  The Company is not in
default with respect to any judgment, order or decree of any court or any
governmental agency or instrumentality.

     3.7  Compliance with Applicable Laws and Other Instruments.  The
business and operations of the Company have been and are being conducted in
accordance with all applicable laws, rules and regulations of all
governmental authorities, the violation of which could reasonably be
expected to have a material adverse impact on the Company.  Neither the
execution nor delivery of, nor the performance of or compliance with, this
Agreement nor the consummation of the transactions contemplated hereby will
conflict with, or, with or without the giving of notice or passage of time,
result in any breach of, or constitute a default under, or result in the
imposition of any lien or encumbrance upon any asset or property of the
Company pursuant to, any applicable law, administrative regulation or
judgment, order or decree of any court or governmental body, any material
agreement or other instrument to which the Company is a party or by which
it or any of its properties, assets or rights is bound or affected, and
will not violate the Company's Certificate of Incorporation or Bylaws.  The
Company is not in violation of its Certificate of Incorporation or its
Bylaws nor in violation of, or in default under, any lien, indenture,
mortgage, lease, material agreement, instrument, commitment or arrangement
in any material respect.  There are no consents required to consummate the
transactions contemplated hereby, which have not been obtained, under any
lien, indenture, mortgage, lease, material agreement, instrument,
commitment or arrangement to which the Company is a party.

     3.8  Preferred Shares, Warrants, Conversion Stock and Warrant Stock.
The Preferred Shares, when issued and paid for pursuant to the terms of
this Agreement, will be duly authorized, validly issued and outstanding,
fully paid and non-assessable, free and clear of all pledges, liens and
encumbrances; the Warrants, when issued and delivered pursuant to this
Agreement, will constitute valid and binding obligations of the Company in
accordance with their terms; the Conversion Stock and the Warrant Stock
have been reserved for issuance based upon the initial Conversion Price and
initial Warrant Exercise Price and when issued upon conversion or exercise
thereof in accordance with the Certificate of Incorporation and the terms
of the Warrants will be duly authorized, validly issued and outstanding,
fully paid, nonassessable and free and clear of all pledges, liens and
encumbrances.  The certificates representing the Preferred Shares and
Warrants to be delivered by the Company hereunder, and the certificates
representing the Conversion Stock to be delivered upon the conversion of
the Preferred Shares and the certificates representing the Warrant Stock to
be delivered upon exercise of the Warrants, will be genuine, and the Company 
has no knowledge of any fact which would impair the validity thereof.

     3.9  Securities Laws.  Based in part upon the representations and
warranties contained in Section 4 hereof, no consent, authorization,
approval, permit or order of or filing with any governmental or regulatory
authority is required under current laws and regulations in connection with
the execution and delivery of this Agreement or the offer, issuance, sale
or delivery of the Securities other than the qualification thereof, if
required, under applicable state securities laws, which qualification has
been or will be effected as a condition of this sale.  The Company has not,
directly or through an agent, offered the Securities, or any similar
securities for sale to, or solicited any offers to acquire such securities
from, persons other than the Investor and other accredited investors.
Under the circumstances contemplated hereby, the offer, issuance, sale and
delivery of the Preferred Shares, the issuance of the Warrants, the offer
of the Conversion Stock and Warrant Stock will not under current laws and
regulations require compliance with the prospectus delivery or registration
requirements of the Securities Act.

     3.10 Patents and Other Intangible Rights.  Except as otherwise set
forth in Exhibit 3 hereto, the Company (a) owns or has the exclusive right
to use, free and clear of all material liens, claims and restrictions, all
of the right, title and interest in the intellectual property acquired from
Schall in the exchange for Common Stock described in Section 5.8 below and
all patents, trademarks, service marks, trade names, copyrights, licenses
and rights with respect to the foregoing, (b) is not obligated or under any
liability to make any payments of a material nature by way of royalties,
fees or otherwise to any owner of, licensor of, or other claimant to, any
patent, trademark, trade name, copyright or other intangible asset, with
respect to the use thereof or in connection with the conduct of its
business or otherwise, (c) owns or has the unrestricted right to use all
trade secrets, including know-how, inventions, designs, processes, computer
programs and technical data necessary to the development, operation and
sale of all products and services sold or proposed to be sold by it, free
and clear of any rights, liens or claims of others, and (d) is not using
any confidential information or trade secrets of others.  To the best of
its knowledge, the Company is not, nor has it received actual notice that
it is, infringing upon or otherwise acting adversely to any known right or
claimed right of any person under or with respect to any patents,
trademarks, service marks, trade names, copyrights, licenses or rights with
respect to the foregoing.

     3.11 Outstanding Debt.  The Company has no Indebtedness for Borrowed
Money except as set forth in Exhibit 3 hereto.  The Company is not in
default in the payment of the principal of or interest or premium on any
such Indebtedness for Borrowed Money, and no event has occurred or is
continuing under the provisions of any instrument, document or agreement
evidencing or relating to any such Indebtedness for Borrowed Money which
with the lapse of time or the giving of notice, or both, would constitute
an event of default thereunder.

     3.12 Corporate Acts and Proceedings.  This Agreement has been duly
authorized by all necessary corporate action on behalf of the Company and
has been duly executed and delivered by authorized officers of the Company.
All corporate action necessary to the authorization, creation, issuance and
delivery of the Securities, has been taken on the part of the Company, or
will be taken by the Company on or prior to the Closing Dates.  This
Agreement is a valid and binding agreement of the Company enforceable in
accordance with its terms, except as the enforceability thereof may be
limited by bankruptcy, insolvency, moratorium, reorganization or other
similar laws affecting the enforcement of creditors' rights generally, and
except for judicial limitations on the enforcement of the remedy of specific 
enforcement and other equitable remedies.

     3.13 No Brokers or Finders.  No person, firm or corporation has or
will have, as a result of any act or omission of the Company, any right,
interest or valid claim against or upon the Company or any Investor for any
commission, fee or other compensation as a finder or broker, or in any
similar capacity, in connection with the transactions contemplated by this
Agreement.  The Company will indemnify and hold the Investor harmless
against any and all liability with respect to any such commission, fee or
other compensation which may be payable or determined to be payable in
connection with the transactions contemplated by this Agreement.

     3.14 Conflicts of Interest.  Except as disclosed on Exhibit 3 hereto,
no officer, director or stockholder of the Company or any affiliate (as
such term is defined in Rule 405 under the Securities Act) of any such
person has any direct or indirect interest (a) in any entity which does
business with the Company, or (b) in any property, asset or right which is
used by the Company in the conduct of its business, or (c) in any contractual 
relationship with the Company other than as an employee.

     3.15 Licenses.  The Company possesses from the appropriate agency,
commission, board and government body and authority, whether state, local
or federal, all licenses, permits, authorizations, approvals, franchises
and rights which (a) are necessary for it to engage in the business
currently conducted by it, and (b) if not possessed by the Company, would
have a material adverse impact on the Company's business.  The Company has
no knowledge that would lead it to believe that it will not be able to
obtain all material licenses, permits, authorizations, approvals, franchises 
and rights that may be required for any business the Company proposes to 
conduct.

     3.16 Registration Rights.  Except as disclosed on Exhibit 3 hereto,
the Company has not granted any registration rights under the Securities
Act relating to any of its authorized or outstanding securities which are
superior or preferential to those granted to the Investor pursuant to this
Agreement.

     3.17 Retirement Plans.  The Company does not have any retirement plan
in which any employees of the Company participate that is subject to any
provisions of the Employee Retirement Income Security Act of 1974, as
amended,  and of the regulations adopted pursuant thereto ("ERISA").

     3.18 Application of Proceeds.  The proceeds from the issue and sale of
the Preferred Shares pursuant to this Agreement will be used to fund working 
capital and other general corporate purposes.

     3.19 Disclosure.  The Company has not knowingly withheld from the
Investor any material facts relating to the assets, business, operations,
financial condition or prospects of the Company.  No representation or
warranty in this Agreement or in any certificate, schedule, statement,
exhibit, annex or other document furnished or to be furnished to any
Investor pursuant hereto or in connection with the transactions contemplated 
hereby contains or will contain any untrue statement of a material fact or 
omits or will omit to state any material fact required to be stated herein or 
therein or necessary to make the statements herein or therein not misleading.

4.   Representations and Warranties of Investor.  The Investor hereby
represents and warrants that:

     4.1  Investment Intent.  The Securities being acquired by the Investor
hereunder or that will be acquired upon conversion of the Preferred Shares
or exercise of the Warrants are being or will be acquired, for the
Investor's own account, not as a nominee or agent, and not with a view to,
or for resale in connection with, any distribution or public offering
thereof within the meaning of the Securities Act and that the Investor has
no present intention of selling, granting, any participation in, or otherwise 
distributing the same.  By executing this Agreement, such Investor further 
represents that such Investor does not have any contract, undertaking, 
agreement or arrangement with any person to sell, transfer or grant 
participations to such person or to any third person, with respect to any of 
the Securities.  The Investor understands that the Securities have not been 
registered under the Securities Act or any applicable state laws by reason of 
their issuance or contemplated issuance in a transaction exempt from the 
registration and prospectus delivery requirements of the Securities Act and 
such laws, and that the reliance of the Company and others upon this 
exemption is predicated in part upon this representation and warranty.  The 
Investor further understands that the Securities may not be transferred or 
resold without (a) registration under the Securities Act and any applicable 
state securities laws, or (b) an exemption from the requirements of the 
Securities Act and applicable state securities laws.

     4.2  Location of Principal Office and Qualification as Accredited
Investor.  The Investor's principal office is located in the state of
Minnesota.  The Investor qualifies as an accredited investor within the
meaning of Rule 501 under the Securities Act.  The Investor has such
knowledge and experience in financial and business matters that it is
capable of evaluating the merits and risks of the investment to be made
hereunder.  The Investor has, and has had, access to all of the Company's
material books and records and access to the Company's executive officers
has been provided to the Investor or to the Investor's qualified agents.
The Investor has received all information with respect to the Company it
deems necessary in order to make its investment decision regarding the
Preferred Shares and the Warrants.

     4.3  Acts and Proceedings.  Investor has full power and authority to
enter into this Agreement, and this Agreement has been duly authorized by
all necessary corporate action on the part of Investor, has been duly
executed and delivered by the Investor and is a valid and binding agreement
upon the Investor.

     4.4  No Brokers or Finders.  No person, firm or corporation has or
will have, as a result of any act or omission by the Investor, any right,
interest or valid claim against the Company for any commission, fee or
other compensation as a finder or broker, or in any similar capacity, in
connection with the transactions contemplated by this Agreement.

     4.5  Disclosure of Information.  Such Investor believes it has
received all the information it considers necessary or appropriate for
deciding whether to purchase the Series A Preferred Stock.  Such Investor
further represents that it has had an opportunity to ask questions and
receive answers from the Company regarding the terms and conditions of the
offering of the Series A Preferred Stock and the business, properties,
prospects and financial condition of the Company.  The foregoing, however,
does not limit or modify the representations and warranties of the Company
in Section 2 of this Agreement or the right of the Investors to rely thereon.

     4.6  Investment Experience.  Such Investor is an investor in
securities of companies in the development stage and acknowledges that it
is able to fend for itself, can bear the economic risk of its investment,
and has such knowledge and experience in financial or business matters that
it is capable of evaluating the merits and risks of the investment in the
Series A Preferred Stock.  Investor also represents it has not been organized 
for the purpose of acquiring the Series A Preferred Stock.

     4.7  Restricted Securities.  Such Investor understands that the
Securities it is purchasing are characterized as "restricted securities"
under the federal securities laws inasmuch as they are being acquired from
the Company in a transaction not involving a public offering and that under
such laws and applicable regulations such securities may be resold without
registration under the Act, only in certain limited circumstances.  In this
connection, such Investor represents that it is familiar with SEC Rule 144,
as presently in effect, and understands the resale limitations imposed
thereby and by the Act.

     4.8  Further Limitations on Disposition.  Without in any way limiting
the representations set forth above, Investor further agrees not to make
any disposition of all or any portion of the Securities unless and until
the transferee has agreed in writing for the benefit of the Company to be
bound by this Section 3, and:

     (a)  There is then in effect a Registration Statement under the Act
covering such proposed disposition and such disposition is made in accordance 
with such Registration Statement; or

     (b)  (i)  Such Investor shall have notified the Company of the
proposed disposition and shall have furnished the Company with a detailed
statement of the circumstances surrounding the proposed disposition, and
(ii) if reasonably requested by the Company, such Investor shall have
furnished the Company with an opinion of counsel, reasonably satisfactory
to the Company that such disposition will not require registration of such
shares under the Act.  It is agreed that the Company will not require
opinions of counsel for transactions made pursuant to Rule 144 except in
unusual circumstances.

     4.9  Legends.  It is understood that the certificates evidencing the
Securities may bear one or all of the following legends:

     (a)  "These securities have not been registered under the Securities
Act of 1933, as amended.  They may not be sold, offered for sale, pledged
or hypothecated in the absence of a registration statement in effect with
respect to the securities under such Act or an opinion of counsel satisfactory 
to the Company that such registration is not required or unless sold pursuant 
to Rule 144 of such Act."

     (b)  Any legend required by state securities laws.

5.   Conditions of Investor's Obligation.  The obligation to purchase and
pay for the Preferred Shares which the Investor has agreed to purchase on
the Closing Dates is subject to the fulfillment prior to or on each Closing
Date of the following conditions:

     5.1  Representations and Warranties.  The representations and
warranties of the Company under this Agreement shall be true in all material 
respects as of each Closing Date with the same effect as though made on and 
as of each Closing Date except the following changes which shall be permitted 
at each Closing subsequent to the date of this Agreement:

          (a)  3.3:  exceptions created by issuances of securities duly
     authorized by formal written resolution of the Board of Directors of
     the Company and not inconsistent with the terms of this Agreement;
     
          (b)  3.5:  exceptions created by any mortgage, pledge, lease,
     lien, charge, securities interest, encumbrance or restriction created
     in the normal course of the Company's business or approved by the
     Board of Directors of the Company;
     
          (c)  3.6:  exceptions created by matters of the nature referred
     to in Section 3.6 which are disclosed to the Investor in writing prior
     to the Closing Date and which if determined adversely to the Company,
     would not have a material adverse effect on the business, operations,
     assets, condition or prospects of the Company.
     
          (d)  3.9:  exceptions created by agreements duly authorized by
     formal written resolution of the Board of Directors of the Company;
     
          (e)  3.11:  exceptions for the incurrence of Indebtedness for
     Borrowed Money duly authorized by formal written resolution of the
     Board of Directors of the Company but not for any default thereunder;
     
          (f)  3.14:  exceptions for conflicts of interest arising from
     transactions duly authorized by formal resolution adopted by a
     majority of the disinterested members of the Board of Directors of the
     Company; and
     
          (g)  3.17:  exceptions created by plans duly authorized by formal
     resolution of the Board of Directors of the Company.
     
     5.2  Compliance with Agreement.  The Company shall have performed and
complied with all agreements, covenants and conditions required by this
Agreement and by the Research and License Agreement attached hereto as
Exhibit 7 to be performed and complied with by it prior to or as of each
Closing Date.

     5.3  Additional Financial Statements.  The Company shall have delivered 
to the Investor the financial statements and information required by Section 
6.3.

     5.4  Certificate of Officers.  The Company shall have delivered to the
Investor a certificate, dated each Closing Date, executed by the President
and the senior financial officer of the Company and certifying to the
satisfaction of the conditions specified in this Section 5.

     5.5  Opinion of Company's Counsel.  On the Closing Date coincident
with the date of this Agreement only, the Company shall have delivered to
the Investor an opinion of Brobeck, Phleger & Harrison LLP, counsel for the
Company, dated the Closing Date, to the effect that:

          (a)  The Company has been duly incorporated and is validly
     existing as a corporation in good standing under the laws of the State
     of Delaware; has the corporate power and authority to enter into this
     Agreement, to issue and sell the Securities as contemplated by this
     Agreement, and to carry out the provisions of this Agreement; has the
     corporate power and authority to own and hold its properties owned and
     leased and to carry on the business in which it is engaged; and has
     not failed to qualify to do business as a foreign corporation in good
     standing in any state or jurisdiction wherein the nature of its 
     activities or of its properties owned or leased makes such qualification 
     necessary and failure to be so qualified would have a material adverse 
     effect upon the Company.
     
          (b)  This Agreement has been duly authorized, executed and
     delivered by the Company, and constitutes a legal, valid and binding
     agreement of the Company enforceable in accordance with its terms.
     
          (c)  The Proprietary Information and Inventions Agreement and
     Vesting Agreement, each dated November 18, 1997 of and between the
     Company and Schall, are legal, valid and binding agreements of the
     Company and Schall enforceable in accordance with their terms.
     
          (d)  The Amendment, substantially in the form set forth as
     Exhibit 1 hereto, has been duly adopted by all necessary corporate
     action, and has been duly filed with the Secretary of State of the
     State of Delaware (no other or additional filing or recording being
     necessary in order for the holders of the Preferred Shares to obtain
     the rights and privileges of the Preferred Shares provided in the
     Amendment).
     
          (e)  The Company is authorized by its Certificate of Incorporation 
     to issue 20,000,000 shares of Common Stock and 6,666,666 Shares of 
     Series A Preferred Stock.  Other than the Series A Preferred Stock to be 
     issued pursuant to this Agreement, there are no shares of Series A 
     Preferred Stock issued and outstanding.  There are 5,143,750 shares of 
     Common Stock duly issued and outstanding, all of which are, to our 
     knowledge, fully paid and nonassessable.  The issuance and sale of such 
     outstanding shares of Common Stock were exempt from registration under 
     the Securities Act and such shares were issued in conformity with the 
     permit or qualification requirements of all applicable state securities 
     laws.  Except for such preferred shares and such common shares, the 
     Company has no other authorized or outstanding series or class of 
     capital stock.  Except for (i) the conversion privileges of the Series A 
     Preferred Stock, (ii) the Warrants and the 1,666,666 shares of Series A 
     Preferred Stock reserved for issuance pursuant to the exercise of the 
     Warrants to be issued pursuant to this Agreement, (iii) 500,000 shares 
     of Common Stock reserved for issuance pursuant to the Company's 1997 
     Stock Option/Stock Issuance Plan, and (iv) the rights set forth in 
     Section 6.13 of the Investment Agreement, there are no preemptive rights 
     or, to our knowledge, options, warrants, conversion privileges or other
     rights (or agreements for any such rights) outstanding to purchase or
     otherwise obtain from the Company any of the Company's equity securities.  
     To the knowledge of such counsel, except as set forth on Exhibit 3 
     hereto, there are no agreements or understandings on the part of the 
     Company with respect to the registration of any securities of the Company 
     under the Securities Act, other than those granted under this Agreement, 
     and there are no obligations on the part of the Company to purchase or 
     redeem any outstanding shares of capital stock of the Company, other 
     than as set forth in the Amendment.
     
          (f)  The respective rights, privileges, restrictions and preferences 
     of the Series A Preferred Stock are as stated in the Amendment.
     
          (g)  The Preferred Shares to be purchased at the Closing have
     been duly authorized and, upon payment for and delivery of such 
     securities in accordance with the terms of this Agreement, will be
     validly issued, fully paid and nonassessable.  The certificates for
     the Preferred Shares when issued, will be in valid and sufficient form, 
     and the Preferred Shares are entitled to the benefits of this Agreement 
     applicable thereto.  The Conversion Stock has been duly authorized and 
     reserved for issuance upon conversion of the Preferred Shares and when 
     issued upon such conversion in accordance with the terms and conditions 
     of the Preferred Shares and those of this Agreement, the Conversion Stock 
     will be duly authorized and issued and will be fully paid and 
     nonassessable.
     
          (h)  The Warrants have been duly authorized and, when issued in
     accordance with the terms and conditions of this Agreement, will be
     duly authorized and issued.  The Warrant Stock has been duly authorized 
     and reserved for issuance upon exercise of the Warrants and when issued 
     upon such exercise in accordance with the terms and conditions of the 
     Warrants and those of this Agreement, the Warrant Stock will be duly 
     authorized and issued and will be fully paid and nonassessable.
     
          (i)  All corporate proceedings required by law or by the
     provisions of this Agreement to be taken by the Board of Directors and
     the stockholders of the Company on or prior to the Closing Date in
     connection with the execution and delivery of this Agreement, the
     offer, issuance and sale of the Securities, and in connection with the
     consummation of the transactions contemplated by this Agreement, have
     been duly and validly taken.
     
          (j)  All consents, approvals, permits, orders or authorizations
     of, and all qualifications, registrations, designations or
     declarations with, any federal or Delaware corporate authority on the
     part of the Company required in connection with the execution and
     delivery of the Investment Agreement and consummation at the Closings
     of the transactions contemplated by the Investment Agreement have been
     obtained, and are effective, and we are not aware of any proceedings,
     or written threat of any proceedings, that question the validity thereof.
     
          (k)  The Company's execution and delivery of, and its performance
     and compliance as of the date hereof with the terms of, the Investment
     Agreement do not violate any provision of any federal, or Delaware
     corporate law, rule or regulation applicable to the Company or any
     provision of the Company's Amended and Restated Certificate of 
     Incorporation or Bylaws and do not conflict with or constitute a default 
     under the provisions of any judgment, writ, decree or order specifically 
     identified in the Schedule of Exceptions or the material provisions of 
     any material agreement specifically identified in the Schedule of 
     Exceptions.
     
          (l)  Assuming the accuracy of the representations of the Investor
     set forth in Section 4. hereof, the offer, sale, issuance and delivery
     of the Preferred Shares, the grant and issuance of the Warrants and
     the offer of the Conversion Stock and Warrant Stock to the Investor
     through conversion by it of the Preferred Shares or exercise by it of
     the Warrants under the circumstances contemplated by the Amendment,
     the Warrants and this Agreement are exempt from the registration and
     prospectus delivery requirements of the Securities Act, and all
     registrations, qualifications, permits and approvals required under
     applicable state securities laws for the lawful offer, sale, issuance
     and delivery of the Preferred Shares, the grant and issuance of the
     Warrants and the offer of the Conversion Stock and Warrant Stock shall
     have been obtained.
     
          (m)  Such counsel has no knowledge of any litigation, proceeding
     or governmental investigation pending or threatened against the
     Company, its key management employees, properties or business which,
     if determined adversely to the Company, would have a material adverse
     effect upon the financial condition, operations, results of operations
     or business of the Company.
     
     5.6  Qualification Under State Securities Laws.  All registrations,
qualifications, permits and approvals required under applicable state
securities laws for the lawful execution and delivery of this Agreement and
the offer, sale, issuance and delivery of the Preferred Shares, the grant
and issuance of the Warrants and the offer of the Conversion Stock and
Warrant Stock shall have been obtained.

     5.7  Proceedings and Documents.  All corporate and other proceedings
and actions taken in connection with the transactions contemplated hereby
and all certificates, opinions, agreements, instruments and documents
mentioned herein or incident to any such transaction shall be satisfactory
in form and substance to the Investor and its counsel.

     5.8  Issuance of Shares in Exchange for Intellectual Property;
Reservation of Shares.  The Company, pursuant to an agreement with Schall,
a copy of which has been previously delivered to the Investor, shall have
issued 5,000,000 shares of Common Stock to Schall in exchange for Schall's
transfer to the Company of all of his right, title and interest in his
intellectual property related to the field of chemokines and chemokine
receptors, including, but not limited to, patent applications and
disclosure documents identified on Schedule B hereto and material related
to patent applications currently in preparation.  Of such 5,000,000 shares,
2,000,000 shares shall be fully vested and the remaining 3,000,000 shall
vest (i.e., the Company's right to repurchase such shares at cost shall
lapse) ratably over the four-year period commencing on the date hereof in
accordance with the terms of a Vesting Agreement in the form of Exhibit 4
hereto.  In addition to the shares issued to Schall, the Company shall have
caused the 143,750 shares of Common Stock previously purchased by employees
and/or consultants of the Company to become subject to a standard four-year
vesting arrangement, and 2,356,250 shares of Common Stock shall be
available for issuance to other key officers, employees and consultants
pursuant to option or benefit plans or other agreements established for the
benefit of officers, employees, consultants and directors of the Company.

     5.9  Employment Agreement and Proprietary Information and Inventions
Agreement.  The Company and Schall shall have entered into an Employment
Agreement substantially in the form of Exhibit 5 hereto and a Proprietary
Information and Inventions Agreement substantially in the form of Exhibit 6
hereto.

     5.10 Co-Sale Agreement.  Schall and all holders of at least 500,000
shares (appropriately adjusted to reflect stock splits, stock dividends,
reorganizations, consolidations and similar changes effected after the
Closing Dates) of the Company's capital stock shall have entered into a Co-
Sale Agreement with the Investor substantially in the form of Exhibit 7
hereto.

     5.11 Research and License Agreement.  R&D Systems and the Company
shall have entered into a Research Agreement substantially in the form of
Exhibit 8 hereto.

     5.12 Directors.  The Company shall have disclosed to the Investor in
writing the identity of and biographical data regarding each of the members
of its Board of Directors as of each Closing Date and each person currently
intended to be nominated for election as a director.

6.   Affirmative Covenants.  Subject to the provisions of Section 9 hereof,
the Company covenants and agrees that:

     6.1  Corporate Existence.  The Company will maintain its corporate
existence in good standing and comply with all applicable laws and
regulations of the United States or of any state or states thereof or of
any political subdivision thereof and of any governmental authority where
failure to so comply would have a material adverse impact on the Company or
its business or operations.

     6.2  Books of Account and Reserves.  The Company will keep books of
record and account in which full, true and correct entries are made of all
of its and their respective dealings, business and affairs, in accordance
with generally accepted accounting principles.  The Company will employ
certified public accountants selected by the Board of Directors of the
Company who are "independent" within the meaning of the accounting regulations 
of the Commission and have annual audits made by such independent public 
accountants in the course of which such accountants shall make such 
examinations, in accordance with generally accepted auditing standards, as 
will enable them to give such reports or opinions with respect to the 
financial statements of the Company and its Subsidiaries as will satisfy the 
requirements of the Commission in effect at such time with respect to 
certificates and opinions of accountants.

     6.3  Furnishing of Financial Statements and Information.  The Company
will deliver to Investor:

          (a)  as soon as practicable, but in any event within 30 days
     after the close of each month, unaudited balance sheets of the Company
     as of the end of such month, together with the related statements of
     operations for such month, setting forth the budgeted figures for such
     month prepared and submitted in connection with the Company's annual
     plan as required under Section 6.5 hereof and in comparative form
     figures for the corresponding month of the previous fiscal year, all
     in reasonable detail and certified by an authorized officer of the
     Company, subject to year-end adjustments;
     
          (b)  as soon as practicable, but in any event within 90 days
     after the end of each fiscal year, a balance sheet of the Company, as
     of the end of such fiscal year, together with the related statements
     of operations, stockholders' equity and cash flow for such fiscal
     year, setting forth in comparative form figures for the previous
     fiscal year, all in reasonable detail and duly certified independent
     public accountants selected by the Board of Directors of the Company,
     which accountants shall have given the Company an opinion, unqualified
     as to the scope of the audit, regarding such statements;
     
          (c)  concurrently with the delivery of any financial statements
     referred to in paragraphs (a) and (b) of this Section 6.3, current
     schedules of Indebtedness for Borrowed Money and Senior Indebtedness
     together with a certificate of the President and the principal
     accounting officer of the Company to the effect that such schedules
     are accurate and correct and that there exists no condition or event
     which constitutes an event of default with respect to any indebtedness
     of the Company, or, if any such condition or event exists, specifying
     the nature and period of existence thereof and what action the Company
     is taking or proposes to take with respect thereto;
     
          (d)  within 90 days after the end of each fiscal year, written
     notice of the current Conversion Price and Warrant Exercise Price,
     including a brief statement indicating any adjustments reasonably
     anticipated;
     
          (e)  promptly after the submission thereof to the Company, copies
     of all reports and recommendations submitted by independent public
     accountants in connection with any annual or interim audit of the 
     accounts of the Company or any of its Subsidiaries made by such
     accountants;
     
          (f)  promptly upon transmission thereof, copies of all reports,
     proxy statements, registration statements and notifications filed by
     it with the Commission pursuant to any act administered by the
     Commission or furnished to stockholders of the Company or to any
     national securities exchange;
     
          (g)  with reasonable promptness, such other financial data
     relating to the business, affairs and financial condition of the
     Company as is available to the Company and as from time to time the
     Investor may reasonably request;
     
          (h)  promptly following the issuance of any Additional Shares of
     Common Stock or of any Convertible Securities, or any options,
     warrants or other rights to purchase Additional Shares of Common Stock
     or Convertible Securities written notice of the amount of securities
     so issued and the total consideration received therefor;
     
          (i)  at least 20 days prior to the earlier of the holding of any
     meeting of the stockholders of the Company for the purpose of
     approving such action, written notice of the terms and conditions of
     such proposed merger, consolidation, plan of exchange, sale, transfer
     or other disposition;
     
          (j)  within 15 days after the Company learns in writing of the
     commencement or threatened commencement of any material suit, legal or
     equitable, or of any claim or assertion that the Company or any of its
     products infringes on the patent rights or other intellectual property
     rights of any person or party, or of any material administrative,
     arbitration or other proceeding against the Company, any of its
     Subsidiaries or their respective businesses, assets or properties,
     written notice of the nature and extent of such suit or proceeding;
     
Notwithstanding anything in this Section 6.3 to the contrary, so long as
the Investor has a representative on the Board of Directors of the Company,
the Company shall not be required to deliver to such Investor the items
contained in paragraphs (h) and (i) above.

     The financial statements which the Company will deliver to the
Investor in accordance with provisions of Section 5.3 hereof shall fairly
present the financial condition and the results of operations, and as to
audited statements, changes in stockholder's equity and cash flow of the
Company as at the respective dates and for the periods referred to in such
financial statements, all in accordance with GAAP, subject in the case of
interim financial statements, to normal recurring year-end adjustments (the
effect of which will not, individually or in the aggregate, be materially
adverse) and the absence of notes (that, if presented, would not differ
materially from those included in previously delivered audited balance
sheets); such financial statements will reflect the consistent application
of such accounting principles throughout the periods involved, except as
disclosed in the notes to such financial statements.

     6.4  Inspection.  The Company will permit the Investor and any
representatives of the Investor to visit and inspect at the Investor's
expense any of the properties of the Company, including its books and
records (and to make photocopies thereof or make extracts therefrom), and
to discuss its affairs, finances, and accounts with its officers, lawyers
and accountants, all to such reasonable extent and at such reasonable times
and intervals as such Investor may reasonably request.  Except as otherwise
required by applicable laws or regulations, the Investor shall maintain,
and shall require its representatives to maintain, all information
confidential to the Company obtained pursuant to Section 6.3 hereof, this
Section 6.4 and Section 6.5 hereof on a confidential basis.

     6.5  Preparation and Approval of Budgets.  At least one month prior to
the beginning of each fiscal year of the Company, the Company shall prepare
and submit to its Board of Directors, for its review and approval, an annual 
plan for such year, which shall include monthly capital and operating expense 
budgets, cash flow statements and profit and loss projections itemized in 
such detail as the Board of Directors may reasonably request.  Each annual 
plan shall be modified as often as is necessary in the judgment of the Board 
of Directors to reflect changes required as a result of operating results and 
other events that occur, or may be reasonably expected to occur, during the 
year covered by the annual plan, and copies of each such modification shall 
be submitted to the Board of Directors.  The Company will, simultaneously 
with the submission thereof to the Board of Directors, deliver a copy of each 
such annual plan and modification thereof to the Investor.

     6.6  Payment of Taxes and Maintenance of Properties.  The Company will:

          (a)  pay and discharge promptly, or cause to be paid and
     discharged promptly when due and payable, all taxes, assessments and
     governmental charges or levies imposed upon it or upon its income or
     upon any of its properties, as well as all material claims of any kind
     (including claims for labor, material and supplies) which, if unpaid,
     might by law become a lien or charge upon its property; provided,
     however, that neither the Company nor any Subsidiary shall be required
     to pay any such tax, assessment, charge, levy or claim if the amount,
     applicability or validity thereof shall currently be contested in good
     faith by appropriate proceedings and if the Company shall have set
     aside on its books reserves (segregated to the extent required by
     generally accepted accounting principles) deemed adequate by it with
     respect thereto; and
     
          (b)  maintain and keep, or cause to be maintained and kept, its
     properties in good repair, working order and condition, and from time
     to time make, or cause to be made, all repairs and renewals and
     replacements which in the opinion of the Company are necessary and
     proper so that the business carried on in connection therewith may be
     properly and advantageously conducted at all times; the Company will
     maintain or cause to be maintained back-up copies of all valuable
     papers and software.
     
     6.7  Insurance.  The Company will obtain and maintain in force such
property damage, public liability, business interruption, worker's
compensation, indemnity bonds and other types of insurance as the Company's
executive officers, after consultation with an accredited insurance broker,
shall determine to be necessary or appropriate to protect the Company from
the insurable hazards or risks associated with the conduct of the Company's
business.  The Company's executive officers shall periodically report to
the Board of Directors on the status of such insurance coverage.  In
addition the Company will obtain and maintain in force life insurance on
the life of Schall, naming the Company as the primary beneficiary thereof,
in the amount of $1,000,000.

          All insurance shall be maintained in at least such amounts and to
such extent as shall be determined to be reasonable by the Board of
Directors; and all such insurance shall be effected and maintained in force
under a policy or policies issued by insurers of recognized responsibility,
except that the Company may effect worker's compensation or similar insurance 
in respect of operations in any state or other jurisdiction either through an 
insurance fund operated by such state or other jurisdiction or by causing to 
be maintained a system or systems of self-insurance which is in accord with 
applicable laws.

     6.8  Scientific Advisory Committee.  The Company shall establish a
scientific advisory committee to which the Investor shall have the right to
designate one member.  The Company shall reimburse such member for the
member's reasonable out-of-pocket expenses incurred with attending meetings
of the committee and shall pay such member the same compensation paid to
other non-employee members of the committee.

     6.9  Directors' and Stockholders' Meetings.  The holders of the
Preferred Shares shall have the right to elect one director of the Company
as set forth in the Amendment.  In addition, the holders of the Preferred
Shares shall have the right to have two additional representatives
designated by it receive timely notice of and attend all meetings of the
Board of Directors of the Company.

          The Company shall reimburse the reasonable out-of-pocket expenses
incurred by the director elected and one of the representatives designated
by the holders of Preferred Shares pursuant to the Amendment in connection
with the attending of meetings by their director designee or carrying out
any other duties by such director designee and representative that may be
specified by the Board of Directors or any committee thereof; shall pay
such director designee the same directors' fees paid to the other
non-employee directors of the Company and shall maintain as part of its
Certificate of Incorporation or Bylaws a provision for the indemnification
of its directors to the full extent permitted by law.

          The Company agrees, as a general practice, to hold a meeting of
its Board of Directors at least once every three months, and during each
year to hold its annual meeting of stockholders on or approximately on the
date provided in its Bylaws.

     6.10 Replacement of Certificates.  Upon receipt of evidence reasonably
satisfactory to the Company of the loss, theft, destruction or mutilation
of the certificates representing any Securities, and, in the case of any
such loss, theft or destruction, upon delivery of a bond of indemnity
satisfactory to the Company, or, in the case of any such mutilation, upon
surrender and cancellation of such certificates, the Company will issue new
certificates representing such Securities of like tenor, in lieu of such
lost, stolen, destroyed or mutilated certificates.

     6.11 Application of Proceeds.  Unless otherwise approved by the
Investor, the net proceeds received by the Company from the sale of the
Preferred Shares shall be used for working capital purposes.  Pending use
of the proceeds in the business, they shall be deposited in a bank or banks
having deposits of $150,000,000 or more, invested in money market mutual
funds having assets of $500,000,000 or more, or invested in securities
issued or guaranteed by the United States Government.

     6.12 Patents and Other Intangible Rights.  The Company will apply for,
or obtain assignments of, or licenses to use, all patents, trademarks,
trademark rights, trade names, trade name rights and copyrights which in the 
opinion of a prudent and experienced businessperson operating in the industry 
in which the Company is operating are desirable or necessary for the conduct 
and protection of the business of the Company.

     6.13 Rights to Purchase Additional Securities.  If (A) the Company
should decide to issue and sell additional shares of any of its capital
stock or any of its warrants, securities convertible into capital stock or
other rights to subscribe for or to purchase any of its capital stock,
other than (a) shares of Common Stock sold in a Public Offering, (b) shares
of Common Stock issued or reserved for issuance to key officers, employees
and consultants pursuant to option or benefit plans adopted by the Company
or other agreements established for the benefit of officers, employees,
consultants and directors of the Company, and the grant of such options
themselves, provided that the aggregate number of shares thus awarded and
issued and issuable pursuant to the exercise of all such options shall not
be in excess of 2,356,250 (appropriately adjusted to reflect stock splits,
stock dividends, reorganizations, consolidations and similar changes
effected after the Closing Date), (c) shares of Common Stock issued upon
conversion of the Preferred Shares, (d) shares of Series A Preferred Stock
issued upon exercise of the Warrants and shares of Common Stock issuable
upon conversion thereof, and (e) shares of Common Stock issued to strategic
partners (all such capital stock, warrants, options and other rights, other
than securities referred to in (a), (b), (c), (d) and (e) above, being
hereinafter sometimes collectively referred to as "Additional Securities"),
and (B) at the time of such decision the Investor owns less than 30% of the
Company's Fully Paid Securities (as defined below) or would own less than
30% of the Company's Fully Paid Securities if the contemplated issuance and
sale were to close, then the Company shall first offer to sell to the
Investor, upon the same terms and conditions as the Company is proposing to
issue and sell such Additional Securities to others, the Investor's pro
rata share (as defined below) of such Additional Securities.  Such offer
shall be made by written notice given to such Investor and specifying
therein the amount of the Additional Securities being offered, the purchase
price and other terms of such offer.  The Investor shall have a period of
30 days from and after the date of receipt by it of such notice within
which to accept such offer.  If the Investor elects to accept such offer in
whole or in part, the Investor shall so accept by written notice to the
Company given within such 30-day period.  If the Investor fails to accept
such offer in whole or in part within such 30-day period, any of such
Additional Securities not purchased by the Investor pursuant to such offer
may be offered for sale to others by the Company for a period of 90 days
from the last day of such 30-day period, but only on the same terms and
conditions as set forth in the initial offer to such Purchaser, free and
clear of the restrictions imposed by this Section 6.13.

     For purposes of the previous paragraph, the Investor's "pro rata
share" is the number of shares of Additional Securities (rounded to the
nearest whole share) as is equal to the product of (a)(i) the number of
shares of Common Stock issued, or issuable upon the exercise or conversion
of rights, options, warrants or Convertible Securities without the payment
of any additional cash consideration or with the payment of a nominal cash
consideration, as the case may be (collectively, "Fully Paid Securities"),
to such Investor immediately prior to the issuance of the Additional
Securities being offered divided by (ii) the total number of Fully Paid
Securities issued or issuable by the Company immediately prior to the
issuance of the Additional Securities, multiplied by (b)  the entire offering 
of Additional Securities.

     6.14 Confidentiality Agreements.  The Company will require each of its
officers, employees and consultants to enter into confidential agreements
with it in a form approved by its Board of Directors.

7.   Negative Covenants.  Subject to the provisions of Section 9 hereof,
the Company will be limited and restricted as follows:

     7.1  Future Registration Rights.  Except for any registration
expressly permitted by Section 8 hereof, the Company will not, without the
prior approval of the Investor, agree with the holders of any securities
issued or to be issued by the Company to register such securities under the
Securities Act nor will it grant any incidental registration rights which
are superior or preferred to those granted to the Investor by this Agreement.

     7.2  Other Restrictions.  The Company will not without the prior
written consent of the Investor, which consent shall not be unreasonably
withheld:

          (a)  authorize or issue any shares of preferred stock or other
     securities with preferences superior to those of the Series A
     Preferred Stock issued to the Investor pursuant to this Agreement,
     provided that preferences which are pro rata on a purchase price per
     share basis with the Investor's Series A Preferred Stock shall not
     constitute "superior" preferences; or
     
          (b)  enter into any agreement, grant any right or take any action
     which would impair or dilute the rights of the Investor's subsidiary,
     Research & Diagnostic Systems, Inc., under the Research and License
     Agreement attached hereto as Exhibit 7.
     
8.   Registration Rights.

     8.1  Required Registration.  If at any time after the earlier to occur
of October 1, 2002 or the six-month anniversary of the Company's initial
Public Offering, the Company shall receive a written request therefor from
the Investor, the Company shall prepare and file a registration statement
under the Securities Act covering the shares of Purchased Stock which are
the subject of such request and shall use its best efforts to cause such
registration statement to become effective.  The Company shall be obligated
to prepare, file and cause to become effective only two registration
statements (other than on Form S-3 or any successor form promulgated by the
Commission ("Form S-3")) pursuant to this Section 8.1, and to pay the
expenses associated with such registration statements; notwithstanding the
foregoing, the Investor may require, pursuant to this Section 8.1, the
Company to file, and to pay the expenses associated with, any number of
registration statements on Form S-3, if such form is then available for use
by the Company.  In the event that the Investor determines for any reason
not to proceed with a registration at any time before a registration
statement has been declared effective by the Commission, and such registration 
statement, if theretofore filed with the Commission, is withdrawn with 
respect to the Purchased Stock covered thereby, and the Investor agrees to 
bear its own expenses incurred in connection therewith and to reimburse the 
Company for the expenses incurred by it attributable to the registration of 
such Purchased Stock, then the Investor shall not be deemed to have exercised 
its right to require the Company to register Purchased Stock pursuant to this 
Section 8.1.

     If, at the time any written request for registration is received by
the Company pursuant to this Section 8.1, the Company has determined to
proceed with the actual preparation and filing of a registration statement
under the Securities Act in connection with the proposed offer and sale for
cash of any of its securities by it or any of its security holders, such
written request shall be deemed to have been given pursuant to Section 8.2
hereof rather than this Section 8.1, and the rights of Investor covered by
such written request shall be governed by Section 8.2 hereof.

     Without the written consent of the Investor, neither the Company nor
any other holder of securities of the Company may include securities in
such registration if in the good faith judgment of the managing underwriter
of such public offering the inclusion of such securities would interfere
with the successful marketing of the Purchased Stock or require the exclusion 
of any portion of the Purchased Stock to be registered.

     8.2  Incidental Registration.  Each time the Company shall determine
to proceed with the actual preparation and filing of a registration
statement under the Securities Act in connection with the proposed offer
and sale for cash of any of its securities by it or any of its security
holders (other than a registration statement on Form S-4, Form S-8 or any
other form that does not permit the inclusion of shares by its security
holders), the Company will give written notice of its determination to the
Investor.  Upon the written request of the Investor given within 30 days
after receipt of any such notice from the Company, the Company will, except
as herein provided, cause all such shares of Purchased Stock requested by
Investor to be registered to be included in such registration statement,
all to the extent requisite to permit the sale or other disposition by the
Investor to be so registered; provided, however, that nothing herein shall
prevent the Company from, at any time, abandoning or delaying any such
registration initiated by it; provided, further, however, that if the
Company determines not to proceed with a registration after the registration 
statement has been filed with the Commission and the Company's decision not to 
proceed is primarily based upon the anticipated public offering price of the 
securities to be sold by the Company, the Company shall promptly complete the 
registration if the Investor wishes to proceed with a public offering of its 
Purchased Stock and will bear all expenses in excess of $100,000 incurred by 
the Company as the result of such registration after the Company has decided 
not to proceed.  If the total amount of securities, including Registrable 
Securities, requested by stockholders to be included in such offering exceeds 
the amount of securities sold other than by the Company that the underwriters 
determine in their sole discretion is compatible with the success of the 
offering, then the Company shall be required to include in the offering only 
that number of such securities, including Registrable Securities, which the
underwriters determine in their sole discretion will not jeopardize the
success of the offering (the securities so included to be apportioned pro
rata among the selling stockholders according to the total amount of 
securities entitled to be included therein owned by each selling stockholder 
or in such other proportions as shall mutually be agreed to by such selling 
stockholders) but in no event shall the amount of securities of the selling 
Holders included in the offering be reduced below 20% of the total amount of 
securities included in such offering, unless such offering is the initial 
public offering of the Company's securities, in which case the selling 
stockholders may be excluded completely if the underwriters make the 
determination described above and no other stockholder's securities are 
included.  For purposes of the preceding parenthetical concerning 
apportionment, for any selling stockholder which is a holder of Registrable 
Securities and which is a partnership or corporation, the partners, retired 
partners and stockholders of such holder, or the estates and family members 
of any such partners and retired partners and any trusts for the benefit of 
any of the foregoing persons shall be deemed to be a single "selling 
stockholder", and any pro-rata reduction with respect to such "selling 
stockholder" shall be based upon the aggregate amount of shares carrying 
registration rights owned by all entities and individuals included in such 
"selling stockholder", as defined in this sentence.

     If any registration pursuant to this Section 8.2 shall be underwritten
in whole or in part, the Company may require that the Purchased Stock
requested for inclusion pursuant to this Section 8.2 be included in the
underwriting on the same terms and conditions as the securities otherwise
being sold through the underwriters. If, in the good faith judgment of the
managing underwriter of such public offering, marketing factors require a
limitation of the number of shares of Purchased Stock to be included in
such public offering, the managing underwriter may limit the number of
shares of Purchased Stock to be so included; provided, however, that any
such limitation shall be pro rata based on the relation that the number of
shares of Purchased Stock requested for inclusion in such public offering
bear to the total number of shares of common stock (including shares of
Purchased Stock) requested for such inclusion by the Investor and by other
persons proposing to sell common stock pursuant to registration rights
granted them by the Company.

     8.3  Registration Procedures.  If and whenever the Company is required
by the provisions of Section 8.1 or 8.2 hereof to effect the registration
of shares of Purchased Stock under the Securities Act, the Company will:

          (a)  prepare and file with the Commission a registration
     statement with respect to such securities, and use its best efforts to
     cause such registration statement to become and remain effective for
     such period as may be reasonably necessary to effect the sale of such
     securities, not to exceed three months;
     
          (b)  prepare and file with the Commission such amendments to such
     registration statement and supplements to the prospectus contained
     therein as may be necessary to keep such registration statement
     effective for such period as may be reasonably necessary to effect the
     sale of such securities, not to exceed two years;
     
          (c)  furnish to the Investor and to the underwriters of the
     securities being registered such reasonable number of copies of the
     registration statement, preliminary prospectus, final prospectus and
     such other documents as such underwriters may reasonably request in
     order to facilitate the public offering of such securities;
     
          (d)  use its best efforts to register or qualify the securities
     covered by such registration statement under such state securities or
     blue sky laws of such jurisdictions as the Investor may reasonably
     request in writing within 30 days following the original filing of
     such registration statement;
     
          (e)  notify the Investor, promptly after it shall receive notice
     thereof, of the time when such registration statement has become
     effective or a supplement to any prospectus forming a part of such
     registration statement has been filed;
     
          (f)  notify the Investor promptly of any request by the
     Commission for the amending or supplementing of such registration
     statement or prospectus or for additional information;
     
          (g)  prepare and file with the Commission, promptly upon the
     request of the Investor, any amendments or supplements to such
     registration statement or prospectus which, in the opinion of counsel
     for such holders (and concurred in by counsel for the Company), is
     required under the Securities Act or the rules and regulations
     thereunder in connection with the distribution of the Purchased Stock
     by such holder;
     
          (h)  prepare and promptly file with the Commission and promptly
     notify the Investor of the filing of such amendment or supplement to
     such registration statement or prospectus as may be necessary to
     correct any statements or omissions if, at the time when a prospectus
     relating to such securities is required to be delivered under the
     Securities Act, any event shall have occurred as the result of which
     any such prospectus or any other prospectus as then in effect would
     include an untrue statement of a material fact or omit to state any
     material fact necessary to make the statements therein, in the light
     of the circumstances in which they were made, not misleading;
     
          (i)  advise the Investor, promptly after it shall receive notice
     or obtain knowledge thereof, of the issuance of any stop order by the
     Commission suspending the effectiveness of such registration statement
     or the initiation or threatening of any proceeding for that purpose
     and promptly use its best efforts to prevent the issuance of any stop
     order or to obtain its withdrawal if such stop order should be issued;
     
          (j)  not file any amendment or supplement to such registration
     statement or prospectus to which the Investor shall have reasonably
     objected on the grounds that such amendment or supplement does not
     comply in all material respects with the requirements of the Securities 
     Act or the rules and regulations thereunder, after having been furnished 
     with a copy thereof at least five business days prior to the filing 
     thereof, unless in the opinion of counsel for the Company the filing of 
     such amendment or supplement is reasonably necessary to protect the 
     Company from any liabilities under any applicable federal or state law 
     and such filing will not violate applicable law; and
     
          (k)  at the request of the Investor, furnish an opinion, dated as
     of the closing date, of the counsel representing the Company for the
     purposes of such registration, addressed to the underwriters, if any,
     and to the Investor making such request, in form and substance as is
     customarily given to underwriters in an underwritten public offering.
     
     8.4  Expenses.  With respect to each registration, including
registrations pursuant to Form S-3, requested pursuant to Section 8.1
hereof (except as otherwise provided in such Section with respect to
registrations voluntarily terminated at the request of the requesting
security holders) and with respect to each inclusion of shares of Purchased
Stock in a registration statement pursuant to Section 8.2 hereof (except as
otherwise provided in Section 8.2 with respect to registrations initiated
by the Company but with respect to which the Company has determined not to
proceed), the Company shall bear the following fees, costs and expenses:
all registration, filing and NASD fees, printing expenses, fees and
disbursements of counsel and accountants for the Company, fees and
disbursements of counsel for the underwriter or underwriters of such
securities (if the Company and/or selling security holders are required to
bear such fees and disbursements), all internal Company expenses, all legal
fees and disbursements and other expenses of complying with state securities 
or blue sky laws of any jurisdictions in which the securities to be offered 
are to be registered or qualified, and the premiums and other costs of 
policies of insurance against liability (if any) arising out of such public 
offering.  Fees and disbursements of counsel and accountants for the selling 
security holders, underwriting discounts and commissions and transfer taxes 
relating to the shares included in the offering by the selling security 
holders, and any other expenses incurred by the selling security holders not 
expressly included above, shall be borne by the selling security holders.

     8.5  Indemnification.  In the event that any Purchased Stock is
included in a registration statement under Section 8.1 or 8.2 hereof:

          (a)  The Company will indemnify and hold harmless the Investor,
     its directors and officers, and any underwriter (as defined in the
     Securities Act) for the Investor and each person, if any, who controls
     the Investor or such underwriter within the meaning of the Securities
     Act, from and against, and will reimburse the Investor and each such
     underwriter and controlling person with respect to, any and all loss,
     damage, liability, cost and expense to which such holder or any such
     underwriter or controlling person may become subject under the
     Securities Act or otherwise, insofar as such losses, damages,
     liabilities, costs or expenses are caused by any untrue statement or
     alleged untrue statement of any material fact contained in such
     registration statement, any prospectus contained therein or any
     amendment or supplement thereto, or arise out of or are based upon the
     omission or alleged omission to state therein a material fact required
     to be stated therein or necessary to make the statements therein, in
     light of the circumstances in which they were made, not misleading;
     provided, however, that the Company will not be liable in any such
     case to the extent that any such loss, damage, liability, cost or
     expense arises out of or is based upon an untrue statement or alleged
     untrue statement or omission or alleged omission so made in conformity
     with information furnished by such holder, such underwriter or such
     controlling person in writing specifically for use in the preparation
     thereof.
     
          (b)  The Investor will indemnify and hold harmless the Company,
     its directors and officers, any controlling person and any underwriter
     from and against, and will reimburse the Company, its directors and
     officers, any controlling person and any underwriter with respect to,
     any and all loss, damage, liability, cost or expense to which the
     Company or any controlling person and/or any underwriter may become
     subject under the Securities Act or otherwise, insofar as such losses,
     damages, liabilities, costs or expenses are caused by any untrue or
     alleged untrue statement of any material fact contained in such
     registration statement, any prospectus contained therein or any
     amendment or supplement thereto, or arise out of or are based upon the
     omission or the alleged omission to state therein a material fact
     required to be stated therein or necessary to make the statements
     therein, in light of the circumstances in which they were made, not
     misleading, in each case to the extent, but only to the extent, that
     such untrue statement or alleged untrue statement or omission or
     alleged omission was so made in reliance upon and in strict conformity
     with written information furnished by such holder specifically for use
     in the preparation thereof.
     
          (c)  Promptly after receipt by an indemnified party pursuant to
     the provisions of paragraph (a) or (b) of this Section 8.5 of notice
     of the commencement of any action involving the subject matter of the
     foregoing indemnity provisions, such indemnified party will, if a
     claim thereof is to be made against the indemnifying party pursuant to
     the provisions of said paragraph (a) or (b), promptly notify the
     indemnifying party of the commencement thereof; but the omission to so
     notify the indemnifying party will not relieve it from any liability
     which it may have to any indemnified party otherwise than hereunder.
     In case such action is brought against any indemnified party and it
     notifies the indemnifying party of the commencement thereof, the
     indemnifying party shall have the right to participate in, and, to the
     extent that it may wish, jointly with any other indemnifying party
     similarly notified, to assume the defense thereof, with counsel
     satisfactory to such indemnified party, provided, however, if the
     defendants in any action include both the indemnified party and the
     indemnifying party and the indemnified party shall have reasonably
     concluded that there may be legal defenses available to it and/or
     other indemnified parties which are different from or additional to
     those available to the indemnifying party, or if there is a conflict
     of interest which would prevent counsel for the indemnifying party
     from also representing the indemnified party, the indemnified party or
     parties shall have the right to select separate counsel to participate
     in the defense of such action on behalf of such indemnified party or
     parties.  After notice from the indemnifying party to such indemnified
     party of its election so to assume the defense thereof, the indemnifying 
     party will not be liable to such indemnified party pursuant to the 
     provisions of said paragraph (a) or (b) for any legal or other expense 
     subsequently incurred by such indemnified party in connection with the 
     defense thereof other than reasonable costs of investigation, unless 
     (i) the indemnified party shall have employed counsel in accordance with 
     the proviso of the preceding sentence, (ii) the indemnifying party shall 
     not have employed counsel satisfactory to the indemnified party to 
     represent the indemnified party within a reasonable time after the 
     notice of the commencement of the action, or (iii) the indemnifying party 
     has authorized the employment of counsel for the indemnified party at the 
     expense of the indemnifying party.
     
9.   Termination of Certain Covenants.  The obligations of the Company and
rights of the Investor under Sections 6.8 and 6.9 hereof shall,
notwithstanding any provisions hereof apparently to the contrary, terminate
and shall be of no further force or effect from and after the date on which
the Company completes a Public Offering in a gross aggregate amount of at
least $10,000,000.

10.  Miscellaneous.

     10.1 Changes, Waivers, etc.  Neither this Agreement nor any provision
hereof may be changed, waived, discharged or terminated orally, but only by
a statement in writing signed by the party against which enforcement of the
change, waiver, discharge or termination is sought.

     10.2 Payment of Fees and Expenses.  The Company and the Investor will
each pay its own expenses incurred in connection with entering into this
Agreement.  Payment of expenses related to disputes arising out of or related 
to this Agreement shall be determined in accordance with Section 10.7 below.

     10.3 Notices.  All notices, requests, consents and other communications 
required or permitted hereunder shall be in writing and shall be delivered, 
or mailed first-class postage prepaid, registered or certified mail,

          (a)  if to Investor, 614 McKinley Place, N.E., Minneapolis,
     Minnesota 55413, Attention: Thomas E. Oland, President, with a copy to
     Timothy M. Heaney, Fredrikson & Byron, P.A., 1100 International
     Centre, 900 Second Avenue South, Minneapolis, Minnesota 55402 or
     
          (b)  if to the Company, c/o MMRI, 325 East Middlefield Road,
     Mountain View, California 94043, Attention:  Dr. Thomas J. Schall, or
     to such other address as the Company may specify by written notice to
     the Investor, with a copy to J. Stephan Dolezalek, Esq., Brobeck,
     Phleger & Harrison LLP, Two Embarcadaro Place, 2200 Geng Road, Palo
     Alto, California 94303
     
and such notices and other communications shall for all purposes of this
Agreement be treated as being effective or having been given if delivered
personally, or, if sent by mail, when received.

     10.4 Survival of Representations and Warranties, etc.  All
representations and warranties contained herein shall survive the execution
and delivery of this Agreement, any investigation at any time made by the
Investor or on their behalf, and the sales and purchases of the Preferred
Shares and payment therefor.  All statements contained in any certificate,
instrument or other writing delivered by or on behalf of the Company pursuant 
hereto or in connection with or contemplation of the transactions herein 
contemplated (other than legal opinions) shall constitute representations and 
warranties by the Company hereunder.

     10.5 Parties in Interest.  All the terms and provisions of this Agreement 
shall be binding upon and inure to the benefit of and be enforceable by the 
respective successors and assigns of the parties hereto, whether so expressed 
or not, and, in particular, shall inure to the benefit of and be enforceable 
by the holder or holders at the time of any of the Purchased Stock.

     10.6 Headings.  The headings of the Sections and paragraphs of this
Agreement have been inserted for convenience of reference only and do not
constitute a part of this Agreement.

     10.7 Arbitration.  Any dispute arising out of or relating to this
Agreement or the alleged breach of it, or the making of this Agreement or
the agreements referenced herein, including claims of fraud in the
inducement, shall be discussed between the disputing parties in a good
faith effort to arrive at a mutual settlement of any such controversy.  If,
notwithstanding, such dispute cannot be resolved, such dispute shall be
settled by binding arbitration.  Judgment upon the award rendered by the
arbitrator may be entered in any court having jurisdiction thereof.  The
arbitrator shall be a retired state or federal judge or an attorney who has
practiced in substantive areas similar to the issues under dispute for at
least 10 years.  If the parties cannot agree on an arbitrator within 20
days, any party may request that the chief judge of the District Court for
Hennepin County, Minnesota, select an arbitrator.  Arbitration will be
conducted pursuant to the provisions of this Agreement, and the commercial
arbitration rules of the America Arbitration Association, unless such rules
are inconsistent with the provisions of this Agreement, but without
submission of the dispute to such Association.  Limited civil discovery
shall be permitted for the production of documents and taking of depositions.  
Unresolved discovery disputes may be brought to the attention of the 
arbitrator who may dispose of such dispute. The arbitrator shall have the 
authority to award any remedy or relief that a court of this state could 
order or grant; provided, however, that punitive of exemplary damages shall 
not be awarded.  The arbitrator may award to the prevailing party, if any, as 
determined by the arbitrator, all of its costs and fees, including the 
arbitrator's fees.  Unless otherwise agreed by the parties, the place of any 
arbitration proceedings shall be Hennepin County, Minnesota.
     
     10.8 Choice of Law.  It is the intention of the parties that the laws
of the State of Minnesota (other than its law with respect to conflicts of
law) shall govern the validity of this Agreement, the construction of its
terms and the interpretation of the rights and duties of the parties.

     10.9 Counterparts.  This Agreement may be executed concurrently in two
or more counterparts, each of which shall be deemed an original, but all of
which together shall constitute one and the same instrument.



     IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

                                 CHEMOCENTRYX, INC.

                                 By:  Thomas J. Schall
                                      ------------------
                                       Thomas J. Schall
                                       President and Chief Executive Officer

                                 TECHNE CORPORATION
     
                                 By:  Thomas E. Oland
                                      ------------------
                                       Thomas E. Oland
                                       President and Chief Executive Officer
                                     
                                     
                                     
                                     
                                Schedule A
                                     
     The following table sets forth the amount, price per share and timing
of the Investor's right and obligation to purchase the Preferred Shares.
The timing shall be the later to occur of the specified date or attainment
of the specified milestone.

<TABLE>
<CAPTION>

     Dollar      Price
     Amount     Per Share*    Series     Date          Milestone
     ------     ----------    ------   ---------       ---------
<S>               <C>         <C>        <C>               <C>     
     $50,000      $1.00       A-1        9/3/97            (3)
     
     $950,000     $1.00       A-1        10/1/97(est.)     (4)
     
     $1,000,000   $1.00       A-1        1/1/98(2)         (5)
     
     $1,000,000   $1.00       A-1        7/1/98(2)         (6)
     
     $1,000,000   $1.00(1)    A-2        1/1/99(2)         (7)
     
     $1,000,000   $1.00(1)    A-3        7/1/99(2)         (8)
     


     (1)The price per share for these investments shall be $1.00 per share*
unless an independent third party, within ninety (90) days of 1/1/99 and
7/1/99, respectively, has made an equivalent share purchase or has made a
binding commitment for an equivalent share purchase, in which case the
price per share shall be the same as that of the independent third party
and provided, however, that if such price per share is increased to more
than $2.00 per share, the Investor shall have the right but not the
obligation to effect such purchase.  In the event the independent third
party is acquiring consideration in addition to equity securities, an
allocation shall be made for purposes of determining equivalence to the
price to Investor.

     (2)Or later as requested by the Company upon completion of the
applicable milestone, subject to (reasonable limit to be defined).

     (3)Signing of Letter of Intent for the transaction depicted in this
Agreement which occurred on September 3, 1997.

     (4)Execution of this Agreement and the Research and License Agreement
required by Section 5.10 hereof.

     (5)Completion of the Company's detailed budget, research and staffing
plan for 1998.

     (6)Progress against the Company's 1998 budget, research and staffing
plan reasonably satisfactory to the Investor.

     (7)Completion of the Company's detailed budget, research and staffing
plan for 1999.

     (8)Progress against the Company's budget, research and staffing plan
for 1999 reasonably satisfactory to the Investor.

     *Appropriately adjusted to reflect stock splits, stock dividends,
reorganizations, consolidations and similar changes effected after the date
hereof.

     The Investor shall be issued at the time of each closing** Warrants in
the form attached hereto as Exhibit 2 to purchase a number of shares of the
applicable series of Series A Preferred Stock of the Company equal to one-
third of the number of Series A Preferred Stock purchased by the Investor
at such closing.  Each Warrant shall expire five years from the date of
issuance.  Warrants shall become exercisable one year after the date of
issuance and be exercisable during a four year period at the following
prices:

          Year of Exercisability             Price
          ----------------------             -----
               First                         $2.00
               Second                        $3.00
               Third                         $4.00
               Fourth                        $5.00


 ** Such closing shall not include any closing that occurs pursuant to
     Investor's election to participate in a future financing under its
     right of first refusal.
     



</TABLE>

<TABLE> <S> <C>

<ARTICLE> 5
       
<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>                          JUN-30-1998
<PERIOD-END>                               DEC-31-1997
<CASH>                                       9,900,167
<SECURITIES>                                22,494,774
<RECEIVABLES>                                8,813,316
<ALLOWANCES>                                    47,000
<INVENTORY>                                  4,013,868
<CURRENT-ASSETS>                            47,171,843
<PP&E>                                      22,119,606
<DEPRECIATION>                              10,538,982
<TOTAL-ASSETS>                              61,651,257
<CURRENT-LIABILITIES>                        5,559,357
<BONDS>                                              0
                                0
                                          0
<COMMON>                                       189,189
<OTHER-SE>                                  54,604,011
<TOTAL-LIABILITY-AND-EQUITY>                61,651,257
<SALES>                                     31,010,000
<TOTAL-REVENUES>                            31,010,000
<CGS>                                        9,431,762
<TOTAL-COSTS>                                9,431,762
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                   0
<INCOME-PRETAX>                              9,221,366
<INCOME-TAX>                                 2,831,000
<INCOME-CONTINUING>                          6,390,366
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                 6,390,366
<EPS-PRIMARY>                                      .34
<EPS-DILUTED>                                      .33
        

</TABLE>


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