DREYFUS TREASURY PRIME CASH MANAGEMENT
24F-2NT, 1995-04-27
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                      DREYFUS TREASURY PRIME CASH MANAGEMENT
                                200 PARK AVENUE
                              NEW YORK, NY  10166


                                                  April 27, 1995


Securities and Exchange Commission
Judiciary Plaza
450 Fifth Street, NW
Washington, DC  20549

       Rule 24f-2 Notice - DREYFUS TREASURY PRIME CASH MANAGEMENT
       Registration Statement No. 33-25941 - CIK #0000843781

Gentlemen:

    Originally, the Registration Statement of Dreyfus Treasury Prime Cash
Management was declared effective by the SEC on March 8, 1985.  On September
30, 1993, Post-Effective Amendment No. 6 to the Fund's Registration Statement,
offering Class A and Class B shares of the Fund, was declared effective by the
SEC.  This Amendment represented the Fund's election to register an indefinite
number of shares of each Class and this Notice represents each Class's Rule
24f-2 filing for the fiscal year ended February 28, 1995.

  The following information is furnished:

                                                  CLASS A           CLASS B

  (a) Shares registered during fiscal
      year other than pursuant to
      Section 24(f):

      P-E Amendment No. 9 eff 11/30/94      551,618,962             None
                                            -----------


  (b) Total number of shares sold during
      fiscal year ended 2/28/95 subject
      to registration under Rule 24f-2,   27,082,964,680 shs   482,039,589 shs
      and the dollar amount thereof:        $27,082,964,680    $482,039,589

  (c) Less shares redeemed during
      fiscal year ended 2/28/95,          28,238,282,216 shs   414,608,139 shs
      and the dollar amount thereof:         $28,238,282,216     $414,608,139
                                            ----------------    --------------
      Net sales (redemptions) during
      fiscal year, and the dollar         (1,155,317,536) shs   67,431,450 shs
      amount thereof [(b) - (c)]:          ($ 1,155,317,536)      $67,431,450
                                          ===================   ==============


      Less shares registered other than
      pursuant to Section 24(f), and the
      dollar amount thereof [(a) above]:   551,618,962  shs         N/A
                                           $  551,618,962
                                           -----------------


   Balance and the dollar                ( 1,706,936,498) shs
   amount thereof:                       ($ 1,706,936,498)
                                          ====================



                                         -2-
                                  CALCULATION OF FEE



    Class A - Since the shares redeemed exceed the shares sold, no
registration fee is required.

    Class B - Net Sales dollar amount of $67,431,450 @ 1/29 of 1% =
$23,252.22.

    Funds in the amount of $23,252.22, representing the registration fee for
Class B shares sold, were wired to CIK #0000843781.  An opinion of counsel is
enclosed.


JJP/rtj                                            Very truly yours,

cc: Mr. J. deMichaelis, SEC                        /s/ John J. Pyburn
    Ms. R. McLaughlin, E&Y
    Mr. S. Rosenberg, BONY                         John J. Pyburn,
                                                   Assistant Treasurer





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