<PAGE> PAGE 1
000 A000000 06/30/2000
000 C000000 0000846800
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 U
001 A000000 DREYFUS LIFE AND ANNUITY INDEX FUND, INC.
001 B000000 811-5719
001 C000000 2129226855
002 A000000 200 PARK AVENUE
002 B000000 NEW YORK
002 C000000 NY
002 D010000 10166
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 N
007 B000000 0
011 A000001 DREYFUS SERVICE CORPORATION
011 B000001 8-13801
011 C010001 NEW YORK
011 C020001 NY
011 C030001 10166
013 A000001 PRICEWATERHOUSE COOPERS L.L.P.
013 B010001 NEW YORK
013 B020001 NY
013 B030001 10019
015 A000001 BOSTON SAFE DEPOSIT AND TRUST COMPANY
015 B000001 C
015 C010001 BOSTON
015 C020001 MA
015 C030001 02109
015 E030001 X
018 000000 Y
019 A000000 Y
019 B000000 172
019 C000000 DREYFUSFAM
020 A000001 SALOMON SMITH BARNEY, INC.
020 B000001 13-1912900
020 C000001 34
020 A000002 DEUTSCHE BANK SECURITIES CORPORATION
020 B000002 13-2730828
020 C000002 8
020 A000003 WEEDEN & CO. LP
020 B000003 13-3364318
020 C000003 5
020 A000004 MORGAN STANLEY DEAN WITTER & CO.
<PAGE> PAGE 2
020 B000004 13-2655998
020 C000004 4
020 A000005 INVESTMENT TECHNOLOGY GROUP, INC.
020 B000005 95-4339369
020 C000005 3
020 A000006 GOLDMAN, SACHS & CO.
020 B000006 13-5108880
020 C000006 2
020 A000007 CANTOR FITZGERALD SECURITIES
020 B000007 13-3680187
020 C000007 1
020 A000008 BEAR, STEARNS & CO. INC.
020 B000008 13-3299429
020 C000008 1
020 A000009 TROSTER SINGER
020 B000009 13-5515160
020 C000009 0
020 A000010 J.P. MORGAN SECURITIES INC.
020 B000010 13-3224016
020 C000010 0
021 000000 59
022 A000001 GREENWICH PARTNERS, INC.
022 B000001 13-3176013
022 C000001 8014112
022 D000001 0
022 A000002 SALOMON SMITH BARNEY, INC.
022 B000002 13-1912900
022 C000002 233124
022 D000002 53759
022 A000003 DEUTSCHE BANK SECURITIES CORPORATION
022 B000003 13-2730828
022 C000003 72578
022 D000003 25394
022 A000004 J.P. MORGAN SECURITIES INC.
022 B000004 13-3224016
022 C000004 48932
022 D000004 0
022 A000005 GOLDMAN, SACHS & CO.
022 B000005 13-5108880
022 C000005 24587
022 D000005 0
022 A000006 CANTOR FITZGERALD SECURITIES
022 B000006 13-3680187
022 C000006 20735
022 D000006 0
022 A000007 MORGAN STANLEY DEAN WITTER & CO.
022 B000007 13-2655998
022 C000007 8444
022 D000007 0
022 A000008 LEHMAN BROTHERS INC.
022 B000008 13-2518466
<PAGE> PAGE 3
022 C000008 1285
022 D000008 6768
022 A000009 MERRILL LYNCH, PIERCE, FENNER & SMITH INC.
022 B000009 13-5674085
022 C000009 5161
022 D000009 0
022 A000010 BEAR, STEARNS & CO. INC.
022 B000010 13-3299429
022 C000010 3220
022 D000010 0
023 C000000 8432340
023 D000000 85921
024 000000 Y
025 A000001 LEHMAN BROTHERS INC.
025 B000001 13-2518466
025 C000001 E
025 D000001 4955
025 A000002 MORGAN STANLEY DEAN WITTER & CO.
025 B000002 13-2655998
025 C000002 E
025 D000002 40862
025 A000003 MERRILL LYNCH, PIERCE, FENNER & SMITH INC.
025 B000003 13-5674085
025 C000003 E
025 D000003 19343
025 A000004 BEAR, STEARNS & CO. INC.
025 B000004 13-3299429
025 C000004 E
025 D000004 1995
025 A000005 J.P. MORGAN SECURITIES INC.
025 B000005 13-3224016
025 C000005 E
025 D000005 7753
025 D000006 0
025 D000007 0
025 D000008 0
028 A010000 153614
028 A020000 0
028 A030000 0
028 A040000 55460
028 B010000 111836
028 B020000 0
028 B030000 0
028 B040000 98935
028 C010000 181908
028 C020000 18515
028 C030000 0
028 C040000 106008
028 D010000 120561
028 D020000 0
028 D030000 0
<PAGE> PAGE 4
028 D040000 118703
028 E010000 137299
028 E020000 0
028 E030000 0
028 E040000 77879
028 F010000 130686
028 F020000 12924
028 F030000 0
028 F040000 107529
028 G010000 835904
028 G020000 31439
028 G030000 0
028 G040000 564514
028 H000000 0
060 A000000 Y
060 B000000 Y
061 000000 0
062 A000000 N
062 B000000 0.0
062 C000000 0.0
062 D000000 0.0
062 E000000 0.0
062 F000000 0.0
062 G000000 0.0
062 H000000 0.0
062 I000000 0.0
062 J000000 0.0
062 K000000 0.0
062 L000000 0.0
062 M000000 0.0
062 N000000 0.0
062 O000000 0.0
062 P000000 0.0
062 Q000000 0.0
062 R000000 0.0
066 A000000 Y
066 B000000 N
066 C000000 N
066 D000000 N
066 E000000 N
066 F000000 N
066 G000000 Y
067 000000 N
068 A000000 N
068 B000000 N
069 000000 Y
071 A000000 441177
071 B000000 107320
071 C000000 5212313
071 D000000 2
072 A000000 6
<PAGE> PAGE 5
072 B000000 2035
072 C000000 39230
072 D000000 0
072 E000000 0
072 F000000 6412
072 G000000 0
072 H000000 0
072 I000000 3
072 J000000 0
072 K000000 0
072 L000000 57
072 M000000 19
072 N000000 80
072 O000000 0
072 P000000 18
072 Q000000 0
072 R000000 25
072 S000000 14
072 T000000 0
072 U000000 0
072 V000000 0
072 W000000 51
072 X000000 6679
072 Y000000 0
072 Z000000 34586
072AA000000 51675
072BB000000 21096
072CC010000 0
072CC020000 91760
072DD010000 25547
072DD020000 0
072EE000000 5891
073 A010000 0.1800
073 A020000 0.0000
073 B000000 0.0400
073 C000000 0.0000
074 A000000 193
074 B000000 39648
074 C000000 5053
074 D000000 0
074 E000000 0
074 F000000 5437577
074 G000000 0
074 H000000 0
074 I000000 0
074 J000000 1932
074 K000000 0
074 L000000 16194
074 M000000 9
074 N000000 5500606
074 O000000 24518
<PAGE> PAGE 6
074 P000000 1105
074 Q000000 0
074 R010000 0
074 R020000 0
074 R030000 0
074 R040000 482
074 S000000 0
074 T000000 5474501
074 U010000 143974
074 U020000 0
074 V010000 38.02
074 V020000 0.00
074 W000000 0.0000
074 X000000 63
074 Y000000 5054
075 A000000 0
075 B000000 5263011
076 000000 0.00
077 A000000 N
SIGNATURE MICHAEL A. ROSENBERG
TITLE SECRETARY