U S BIOSCIENCE INC
8-K, 1995-06-07
PHARMACEUTICAL PREPARATIONS
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                     SECURITIES AND EXCHANGE COMMISSION
                           Washington, D.C. 20549
                                               
                            -------------------

                                  FORM 8-K
                          CURRENT REPORT PURSUANT
                       TO SECTION 13 OR 15(d) OF THE
                      SECURITIES EXCHANGE ACT OF 1934
                                            
                               -------------




     Date of Report (Date of Earliest Event Reported):  May 19, 1995

                           U.S. BIOSCIENCE, INC.
- ---------------------------------------------------------------------------
           (Exact Name of Registrant as Specified in its Charter)

                                  Delaware
- ---------------------------------------------------------------------------
               (State or Other Jurisdiction of Incorporation)

            1-10392                                    23-2460100
- ------------------------------               ------------------------------
   (Commission File Number)                         (I.R.S. Employer
                                                   Identification No.)

               One Tower Bridge
               100 Front Street
       Westt Conshohocken, Pennsylvania                        19428
- ---------------------------------------------          --------------------
   (Address of Principal Executive Offices)                 (Zip Code)

                               (215) 832-0570
- ---------------------------------------------------------------------------
            (Registrant's Telephone Number, Including Area Code)

                                    N/A
- ---------------------------------------------------------------------------
       (Former Name or Former Address, if Changed Since Last Report)
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Item 5.  Other Events
- ------   ------------

     Adoption of Stockholder Rights Plan
     -----------------------------------

          On May 19, 1995, the Board of Directors of the Company declared a
dividend of one Preferred Stock Purchase Right (the "Right(s)") for each
outstanding share of Common Stock, par value $0.005 per share (the "Common
Stock"), of the Company.  The dividend is payable as of May 29, 1995 to
stockholders of record on that date.  Each Right entitles the registered
holder to purchase from the Company one one-hundredth (1/100) of a share of
a new series of preferred shares of the Company, designated as Series A
Junior Preferred Stock ("Preferred Stock"), at a price of $15 per one
one-hundredth (1/100) of a share (the "Exercise Price"), subject to certain
adjustments.  The description and terms of the Rights are set forth in a
Rights Agreement, dated as of May 19, 1995, (the "Rights Agreement"), between
the Company and Chemical Mellon Shareholder Services L.L.C., as Rights 
Agent ("Rights Agent").

          Initially the Rights will not be exercisable, certificates will
not be sent to stockholders, and the Rights will automatically trade with
the Common Stock.

          The Rights, unless earlier redeemed by the Board of Directors,
become exercisable upon the close of business on the day (the "Distribution
Date") which is the earlier of (i) the tenth day following a public
announcement that a person or group of affiliated or associated persons,
with certain exceptions set forth below, has acquired beneficial ownership
of 15% or more of the outstanding voting stock of the Company (an

























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"Acquiring Person") and (ii) the tenth business day (or such later date as
may be determined by the Board of Directors prior to such time as any
person or group of affiliated or associated persons becomes an Acquiring
Person) after the date of the commencement or announcement of a person's or
group's intention to commence a tender or exchange offer the consummation
of which would result in the ownership of 30% or more of the Company's
outstanding voting stock (even if no shares are actually purchased pursuant
to such offer); prior thereto, the Rights would not be exercisable, would
not be represented by a separate certificate, and would not be transferable
apart from the Company's Common Stock, but will instead be evidenced, with
respect to any of the Common Stock certificates outstanding as of May 29,
1995, by such Common Stock certificate with a copy of this Summary of
Rights attached thereto.  An Acquiring Person does not include (A) the
Company, (B) any subsidiary of the Company, (C) any employee benefit plan
or employee stock plan of the Company or of any subsidiary of the Company,
or any trust or other entity organized, appointed, established or holding
Common Stock for or pursuant to the terms of any such plan or (D) any
person or group whose ownership of 15% or more of the shares of voting
stock of the Company then outstanding results solely from (i) any action or
transaction or transactions approved by the Board of Directors before such
person or group became an Acquiring Person or (ii) a reduction in the
number of issued and outstanding shares of voting stock of the Company
pursuant to a transaction or transactions approved by the Board of
Directors (provided that any person or group that does not become an
Acquiring Person by reason of clause (i) or (ii) above shall become an
Acquiring Person upon acquisition of an additional 1% of the Company's
voting stock unless such acquisition of additional voting stock will not



































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result in such person or group becoming an Acquiring Person by reason of
such clause (i) or (ii)). 

          Until the Distribution Date (or earlier redemption or expiration
of the Rights), new Common Stock certificates issued after May 29, 1995
will contain a legend incorporating the Rights Agreement by reference. 
Until the Distribution Date (or earlier redemption or expiration of the
Rights), the surrender for transfer of any of the Company's Common Stock
certificates outstanding as of May 29, 1995 with or without a copy of the
Summary of Rights attached, will also constitute the transfer of the Rights
associated with the Common Stock represented by such certificate.  As soon
as practicable following the Distribution Date, separate certificates
evidencing the Rights ("Right Certificates") will be mailed to holders of
record of the Company's Common Stock as of the close of business on the
Distribution Date and such separate certificates alone will evidence the
Rights from and after the Distribution Date.

          The Rights are not exercisable until the Distribution Date.  The
Rights will expire at the close of business on May 19, 2005, unless earlier
redeemed by the Company as described below.

          The Preferred Stock is non-redeemable and, unless otherwise
provided in connection with the creation of a subsequent series of
preferred stock, subordinate to any other series of the Company's preferred
stock.  The Preferred Stock may not be issued except upon exercise of
Rights.  Each share of Preferred Stock will be entitled to receive when, as
and if declared, a quarterly dividend in an amount equal to the greater of
$1.00 per share and 100 times the cash dividends declared on the Company's
Common Stock.  In addition, the Preferred Stock is entitled to 100 times
any non-cash dividends (other than dividends payable in equity securities)



































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declared on the Common Stock, in like kind.  In the event of liquidation,
the holders of Preferred Stock will be entitled to receive for each share
of Series A Preferred Stock, a liquidation payment in an amount equal to
the greater of $1,500 or 100 times the payment made per share of Common
Stock.  Each share of Preferred Stock will have 100 votes, voting together
with the Common Stock.  In the event of any merger, consolidation or other
transaction in which Common Stock is exchanged, each share of Preferred
Stock will be entitled to receive 100 times the amount received per share
of Common Stock.  The rights of Preferred Stock as to dividends,
liquidation and voting are protected by anti-dilution provisions.

          The number of shares of Preferred Stock issuable upon exercise of
the Rights is subject to certain adjustments from time to time in the event
of a stock dividend on, or a subdivision or combination of, the Common
Stock.  The Exercise Price for the Rights is subject to adjustment in the
event of extraordinary distributions of cash or other property to holders
of Common Stock.

          Unless the Rights are earlier redeemed or the transaction is
approved by the Board of Directors and the Continuing Directors, in the
event that, after the time that the Rights become exercisable, the Company
were to be acquired in a merger or other business combination (in which any
shares of the Company's Common Stock are changed into or exchanged for
other securities or assets) or more than 50% of the assets or earning power
of the Company and its subsidiaries (taken as a whole) were to be sold or
transferred in one or a series of related transactions, the Rights
Agreement provides that proper provision will be made so that each holder
of record of a Right will from and after such date have the right to
receive, upon payment of the Exercise Price, that number of shares of






































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common stock of the acquiring company having a market value at the time of
such transaction equal to two times the Exercise Price.  In addition,
unless the Rights are earlier redeemed, if a person or group (with certain
exceptions) becomes the beneficial owner of 15% or more of the Company's
voting stock (other than pursuant to a tender or exchange offer (a
"Qualifying Tender Offer") for all outstanding shares of Common Stock that
is approved by the Board of Directors, after taking into account the long-
term value of the Company and all other factors they consider relevant in
the circumstances), the Rights Agreement provides that proper provision
will be made so that each holder of record of a Right, other than the
Acquiring Person (whose Rights will thereupon become null and void), will
thereafter have the right to receive, upon payment of the Exercise Price,
that number of shares of the Company's Preferred Stock having a market
value at the time of the transaction equal to two times the Exercise Price
(such market value to be determined with reference to the market value of
the Company's Common Stock as provided in the Rights Agreement).

          Fractions of shares of Preferred Stock (other than fractions that
are integral multiples of one one-hundredth (1/100) of a share) may, at the
election of the Company, be evidenced by depositary receipts.  The Company
may also issue cash in lieu of fractional shares which are not integral
multiples of one one-hundredth (1/100) of a share.

          At any time on or prior to the close of business on the tenth day
after the time that a person has become an Acquiring Person (or such later
date as a majority of the Board of Directors and a majority of the
Continuing Directors (as defined in the Rights Agreement) may determine),
the Company may redeem the Rights in whole, but not in part, at a price of
$.001 per Right ("Redemption Price").  The Rights may be redeemed after the










































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time that any Person has become an Acquiring Person only if approved by a
majority of the Continuing Directors.  Immediately upon the effective time
of the action of the Board of Directors of the Company authorizing
redemption of the Rights, the right to exercise the Rights will terminate
and the only right of the holders of the Rights will be to receive the
Redemption Price.

          For as long as the Rights are then redeemable, the Company may,
except with respect to the redemption price or date of expiration of the
Rights, amend the Rights in any manner, including an amendment to extend
the time period in which the Rights may be redeemed.  At any time when the
Rights are not then redeemable, the Company may amend the Rights in any
manner that does not materially adversely affect the interests of holders
of the Rights as such.  Amendments to the Rights Agreement from and after
the time that any Person becomes an Acquiring Person requires the approval
of a majority of the Continuing Directors (as provided in the Rights
Agreement).

          Until a Right is exercised, the holder, as such, will have no
rights as a stockholder of the Company, including, without limitation, the
right to vote or to receive dividends.

          As of March 15, 1995 there were 40,770,780 shares of Common Stock
issued and outstanding (and 7,341,342 and 1,096,634 shares reserved for
issuance under the Company's existing stock option plans and warrants,
respectively).  500,000 shares of Preferred Stock have been reserved for
issuance upon exercise of the Rights.

          The Rights have certain anti-takeover effects.  The Rights will
cause substantial dilution to a person or group who attempts to acquire the
Company on terms not approved by the Company's Board of Directors.  The































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Rights should not interfere with any merger or other business combination
approved by the Board since they may be redeemed by the Company at $.01 per
Right at any time until the close of business on the tenth day (or such
later date as described above) after a person or group has obtained
beneficial ownership of 15% or more of the voting stock.

          The form of Rights Agreement between the Company and Chemical
Mellon Shareholder Services, L.L.C., as rights agent, specifying the terms
of the Rights, which includes as Exhibit A the form of Summary of Rights to
Purchase Series A Junior Preferred Stock, as Exhibit B the form of Right
Certificate and as Exhibit C the form of Certificate of Designations of the
Company setting forth the terms of the Preferred Stock are attached hereto
as exhibits and incorporated herein by reference.  The foregoing
description of the Rights is qualified by reference to such exhibits.


























































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Item 7.   Financial Statements, Pro Forma Financial
- ------    -----------------------------------------
          Information and Exhibits.
          ------------------------

     (c)  Exhibits.

          1.   Rights Agreement dated as of May 19, 1995 between U.S.
               Bioscience, Inc. and Chemical Mellon Shareholder Services
               L.L.C. as Rights Agent.  The Rights Agreement includes as
               Exhibit B the form of Right Certificate and as Exhibit C the
               form of Certificate of Designations.

          2.   Press Release, dated May 19, 1995.
                                    

























































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                                 SIGNATURES
                                 ----------

          Pursuant to the requirements of the Securities Exchange Act of
1934, the registrant has duly caused this report to be signed on its behalf
by the undersigned hereunto duly authorized.

                         U.S. BIOSCIENCE, INC.


                         By: /s/ Robert I. Kriebel
                           -----------------------------
                            Name: Robert I. Kriebel
                            Title: Senior Vice President



June 7, 1995<PAGE>

<PAGE>


                               EXHIBIT INDEX


Exhibit No.         Description                                        Page
- ----------          -----------                                        ----

     1.        Rights Agreement dated as of May 19, 1995 between U.S.
               Bioscience, Inc. and Chemical Mellon Shareholder
               Services L.L.C. as Rights Agent. The Rights Agreement
               includes as Exhibit B the form of Right Certificate and
               as Exhibit C the form of Certificate of Designations.

     2.        Press Release, dated May 19, 1995.
                                   





















































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=============================================================================




                                RIGHTS AGREEMENT

                                 by and between

                              U.S. BIOSCIENCE, INC.

                                       and

                   CHEMICAL MELLON SHAREHOLDER SERVICES L.L.C.

                                 as Rights Agent

                                 _______________

                                   Dated as of
                                  May 19, 1995











=============================================================================






























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                                TABLE OF CONTENTS
                                -----------------

     Section                                                           Page
                                                                       ----

     1.  Certain Definitions . . . . . . . . . . . . . . . . . . . . .    2

     2.  Appointment of Rights Agent . . . . . . . . . . . . . . . . .   14

     3.  Issuance of Right Certificates  . . . . . . . . . . . . . . .   14

     4.  Form of Right Certificates  . . . . . . . . . . . . . . . . .   18

     5.  Countersignature and Registration . . . . . . . . . . . . . .   19

     6.  Transfer, Split Up, Combination and Exchange of Right
         Certificates; Mutilated, Destroyed, Lost or Stolen Right 
         Certificates  . . . . . . . . . . . . . . . . . . . . . . . .   20

     7.  Exercise of Rights; Exercise Price; Expiration Date of Rights   22

     8.  Cancellation and Destruction of Right Certificates  . . . . .   27

     9.  Reservation and Availability of Shares of Preferred Stock . .   28

     10. Preferred Stock Record Date . . . . . . . . . . . . . . . . .   31

     11. Adjustment of Exercise Price or Number of Shares  . . . . . .   31

     12. Certification of Adjusted Exercise Price or Number of
             Shares  . . . . . . . . . . . . . . . . . . . . . . . . .   41

     13. Consolidation, Merger or Sale or Transfer of Assets or
             Earning Power . . . . . . . . . . . . . . . . . . . . . .   42

     14. Fractional Rights and Fractional Shares . . . . . . . . . . .   50

     15. Rights of Action  . . . . . . . . . . . . . . . . . . . . . .   51

     16. Agreement of Right Holders  . . . . . . . . . . . . . . . . .   52

     17. Right Certificate Holder Not Deemed a Stockholder . . . . . .   53

     18. Concerning the Rights Agent . . . . . . . . . . . . . . . . .   54






























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     Section                                                           Page
     -------                                                           ----

     19. Merger or Consolidation of, or Change in Name of, the
             Rights Agent  . . . . . . . . . . . . . . . . . . . . . .   55

     20. Duties of Rights Agent  . . . . . . . . . . . . . . . . . . .   57

     21. Change of Rights Agent  . . . . . . . . . . . . . . . . . . .   60

     22. Issuance of New Right Certificates  . . . . . . . . . . . . .   62

     23. Redemption  . . . . . . . . . . . . . . . . . . . . . . . . .   63

     24. Notice of Proposed Actions  . . . . . . . . . . . . . . . . .   65

     25. Notices . . . . . . . . . . . . . . . . . . . . . . . . . . .   67

     26. Supplements and Amendments  . . . . . . . . . . . . . . . . .   68

     27. Successors  . . . . . . . . . . . . . . . . . . . . . . . . .   70

     28. Benefits of this Rights Agreement . . . . . . . . . . . . . .   70

     29. Delaware Contract . . . . . . . . . . . . . . . . . . . . . .   70

     30. Counterparts  . . . . . . . . . . . . . . . . . . . . . . . .   70

     31. Descriptive Headings  . . . . . . . . . . . . . . . . . . . .   71

     32. Severability  . . . . . . . . . . . . . . . . . . . . . . . .   71


     Exhibit A       -- Summary of Rights

     Exhibit B       -- Form of Right Certificate

     Exhibit C       -- Form of Certificate of Designations of
                        Series A Junior Preferred Stock 





















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                                RIGHTS AGREEMENT

               Agreement, dated as of May 19, 1995, by and between U.S.
     BIOSCIENCE, INC., a Delaware corporation (the "Company"), and Chemical
     Mellon Shareholder Services L.L.C., a New Jersey Limited Liability
     Company (the "Rights Agent").


                              W I T N E S S E T H :
                              -------------------

               WHEREAS, on May 19, 1995, the Board of Directors of the
     Company authorized the issuance of, and declared a dividend payable
     in, one right (a "Right") for each share of Common Stock, $0.005 par
     value per share, of the Company outstanding as of the close of
     business on May 29, 1995 (the "Record Date"), each such Right
     representing the right to purchase one one-hundredth of a share of
     Series A Junior Preferred Stock of the Company ("Preferred Stock")
     having the rights and preferences set forth in the form of Certificate
     of Designations attached hereto as Exhibit C authorized by the Board
     of Directors on May 19, 1995, upon the terms and subject to the
     conditions hereinafter set forth; and

               WHEREAS, the Board of Directors of the Company further
     authorized the issuance of one Right (subject to adjustment) with
     respect to each share of Common Stock which may be issued between the
     Record Date and the earlier to occur of the Expiration Date



































     
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     or the Final Expiration Date (as such terms are hereinafter defined);

               NOW, THEREFORE, in consideration of the premises and the
     mutual agreements herein set forth, the parties hereby agree as
     follows:

               Section 1.  Certain Definitions.  For purposes of this
                           -------------------
     Agreement, the following terms shall have the meanings indicated:

                    (a)  "Acquiring Person" shall mean any Person (as such
               term is hereinafter defined) who or which, together with all
               Affiliates (as such term is hereinafter defined) and
               Associates (as such term is hereinafter defined) of such
               Person, shall be the Beneficial Owner (as such term is
               hereinafter defined) of 15% or more of the Voting Stock of
               the Company then outstanding; provided, that, an Acquiring 
                                             --------
               Person shall not include (i) an Exempt Person (as such term
               is hereinafter defined) or (ii) any Person, together with
               all Affiliates and Associates of such Person, who or which
               would be an Acquiring Person solely by reason of (A) being
               the Beneficial Owner of shares of Voting Stock of the
               Company, the Beneficial Ownership of which was acquired by
               such Person pursuant to any action or transaction or series
               of related actions or transactions approved by the Board of
               Directors before such






































     
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               Person otherwise became an Acquiring Person or (B) a
               reduction in the number of issued and outstanding shares of
               Voting Stock of the Company pursuant to a transaction or a
               series of related transactions approved by the Board of
               Directors of the Company; provided, further, that in the 
                                         --------  -------
               event such Person described in this clause (ii) does not
               become an Acquiring Person by reason of subclause (A) or (B)
               of this clause (ii), such Person nonetheless shall become an
               Acquiring Person in the event such Person thereafter
               acquires Beneficial Ownership of an additional 1% of the
               Voting Stock of the Company, unless the acquisition of such
               additional Voting Stock would not result in such Person
               becoming an Acquiring Person by reason of subclause (A) or
               (B) of this clause (ii).  Notwithstanding the foregoing, if
               the Board of Directors of the Company determines in good
               faith (but only if at the time of such determination by the
               Board of Directors there are then in office not less than
               two Continuing Directors and such action is approved by a
               majority of the Continuing Directors then in office) that a
               Person who would otherwise be an "Acquiring Person" as
               defined pursuant to the foregoing provisions of this
               paragraph (a) has become such inadvertently, and such Person
               divests as



































     
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               promptly as practicable a sufficient number of shares of
               Common Stock so that such Person would no longer be an
               "Acquiring Person" as defined pursuant to the foregoing
               provisions of this paragraph (a), then such Person shall not
               be deemed an "Acquiring Person" for any purposes of this
               Rights Agreement.

                    (b)  "Affiliate" shall have the meaning ascribed to
               such term in Rule 12b-2 of the General Rules and Regulations
               under the Securities Exchange Act of 1934, as amended
               ("Exchange Act"), as in effect on the date of this Rights
               Agreement.

                    (c)  "Associate" of a Person (as such term is
               hereinafter defined) shall mean (i) with respect to a
               corporation, any officer or director thereof or of any
               Subsidiary (as such term is hereinafter defined) thereof, or
               any Beneficial Owner (as such term is hereinafter defined)
               of 10% or more of any class of equity security thereof, (ii)
               with respect to an association, any officer or director
               thereof or of a Subsidiary thereof, (iii) with respect to a
               partnership, any general partner thereof or any limited
               partner thereof who is, directly or indirectly, the
               Beneficial Owner of a 10% ownership interest therein, (iv)
               with respect to a business trust, any officer or trustee
               thereof or of



























     
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               any Subsidiary thereof, (v) with respect to any other trust
               or an estate, any trustee, executor or similar fiduciary or
               any Person who has a 15% or greater interest as a
               beneficiary in the income from or principal of such trust or
               estate, (vi)  with respect to a natural person, any relative
               or spouse of such person, or any relative of such spouse,
               who has the same home as such person, and (vii) any
               Affiliate of such Person.

                    (d)  A person shall be deemed the "Beneficial Owner"
               of, or to "Beneficially Own", any securities (and
               correlative terms shall have correlative meanings):

                         (i)  which such Person or any of such Person's
                    Affiliates or Associates beneficially owns, directly or
                    indirectly, for purposes of Section 13(d) of the
                    Exchange Act and Regulations 13D and 13G thereunder (or
                    any comparable or successor law or regulation), in each
                    case as in effect on the date hereof; or

                        (ii)  which such Person or any of such Person's
                    Affiliates or Associates has (A) the right to acquire
                    (whether such right is exercisable immediately or only
                    after the passage of time or the fulfillment of a
                    condition or both) pursu-











































     
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                    ant to any agreement, arrangement or understanding, or
                    upon the exercise of conversion rights, exchange
                    rights, other rights (other than these Rights),
                    warrants or options, or otherwise; provided, however, 
                                                       --------  -------
                    that a Person shall not be deemed the "Beneficial
                    Owner" of, or to "Beneficially Own", securities
                    tendered pursuant to a tender or exchange offer made by
                    such Person or any of such Person's Affiliates or
                    Associates until such tendered securities are accepted
                    for purchase or exchange or (B) the right to vote,
                    alone or in concert with others, pursuant to any
                    agreement, arrangement or understanding (whether or not
                    in writing); provided, however, that a Person shall not
                                 --------  -------
                    be deemed the "Beneficial Owner" of, or to
                    "Beneficially Own", any securities if the agreement,
                    arrangement or understanding to vote such security (1)
                    arises solely from a revocable proxy or consent given
                    in response to a proxy or consent solicitation made
                    pursuant to, and in accordance with, the applicable
                    rules and regulations under the Exchange Act and (2) is
                    not at the time reportable by such Person on a Schedule
                    13D report under the Exchange Act (or any comparable or
                    suc










































     
<PAGE>

<PAGE>
     

                    cessor report), other than by reference to a proxy or
                    consent solicitation being conducted by such Person; or

                       (iii)  which are beneficially owned, directly or
                    indirectly, by any other Person with which such Person
                    or any of such Person's Affiliates or Associates has
                    any agreement, arrangement or understanding (whether or
                    not in writing) for the purpose of acquiring, holding,
                    voting (except as described in clause (B) of
                    subparagraph (ii) of this paragraph (d)) or disposing
                    of any securities of the Company; provided, however, 
                                                      --------  -------
                    that for purposes of determining Beneficial Ownership
                    of securities under this Rights Agreement, officers and
                    directors of the Company solely by reason of their
                    status as such shall not constitute a group
                    (notwithstanding that they may be Associates of one
                    another or may be deemed to constitute a group for
                    purposes of Section 13(d) the Exchange Act) and shall
                    not be deemed to own shares owned by another officer or
                    director of the Company.

                    Notwithstanding anything in this paragraph (d) to the
               contrary, a Person shall not be deemed the "Beneficial
               Owner" of, or to "Beneficially Own," any










































     
<PAGE>

<PAGE>
     

               security beneficially owned by another Person solely by
               reason of an agreement, arrangement or understanding with
               such other Person for the purposes of:  (x) soliciting the
               Company's stockholders for the election of director nominees
               or any other stockholder resolution, the formation of and
               membership on any committee for the purpose of promoting or
               opposing any stockholder resolution or for electing a slate
               of nominees to the Company's Board of Directors, service on
               such a slate of nominees, or agreement to a slate of direc-
               tor nominees, provided, that such other Person retains the 
                             --------
               right at any time to withdraw as a nominee or member of any
               such committee, and to withhold or revoke any vote or proxy
               for or against any such stockholder resolution or for such
               slate of nominees; (y) entering into revocable voting
               agreements or the granting or solicitation of revocable
               proxies with respect to any of the matters described in the
               foregoing clause (x); or (z) the sharing of expenses and the
               indemnification against expenses and liabilities by any such
               other Person with respect to expenses incurred or conduct
               occurring during the time such other Person is a nominee or
               a member of any such committee described in the foregoing
               clause (x).  Further, notwithstanding






































     
<PAGE>

<PAGE>
     

               anything in this paragraph (d) to the contrary, a Person
               engaged in the business of underwriting securities shall not
               be deemed the "Beneficial Owner" of, or to "Beneficially
               Own," any securities acquired in good faith in a firm
               commitment underwriting until the expiration of forty days
               after the date of such acquisition.

                    (e)  "Business Day" shall mean any day other than a
               Saturday, Sunday, or a day on which banking institutions in
               the State of Pennsylvania are authorized or obligated by law
               or executive order to close.

                    (f)  "Close of Business" on any given date shall mean
               5:00 P.M., Pennsylvania time, on such date; provided, 
                                                           --------
               however, that if such date is not a Business Day it shall 
               -------
               mean 5:00 P.M., Pennsylvania time, on the next succeeding
               Business Day.

                    (g)  "Common Stock" when used with reference to the
               Company shall collectively mean the Common Stock, $0.005 par
               value, of the Company.  "Common Stock" when used with
               reference to any Person other than the Company which shall
               be organized in corporate form shall mean the capital stock
               or other equity security with the greatest per share voting
               power of such Person.  "Common Stock" when used with
               reference to any











































     
<PAGE>

<PAGE>
     

               Person other than the Company which shall not be organized
               in corporate form shall mean units of beneficial interest
               which shall represent the right to participate in profits,
               losses, deductions and credits of such Person and which
               shall be entitled to exercise the greatest voting power per
               unit of such Person.

                    (h)  "Continuing Director" shall mean any member of the
               Board of Directors, while such person is a member of the
               Board of Directors, who is not an Acquiring Person, or an
               Affiliate or Associate of an Acquiring Person, or a
               representative or nominee of an Acquiring Person or of any
               such Affiliate or Associate, and who either (i) was a member
               of the Board of Directors prior to the time that any Person
               became an Acquiring Person (other than pursuant to a
               Qualifying Tender Offer) or (ii) subsequently became a
               member of the Board of Directors, and whose nomination for
               election or election to the Board of Directors was recom-
               mended or approved by a majority of the Continuing Directors
               then on the Board of Directors.

                    (i)  "Distribution Date" shall have the meaning set
               forth in Section 3(b) hereof.

                    (j)  "Exchange Act" shall have the meaning set forth in
               Section 1(b) hereof.








































     
<PAGE>

<PAGE>
     

                    (k)  "Exempt Person" shall mean (i) the Company, (ii)
               any Subsidiary of the Company or (iii) any employee benefit
               plan or employee stock plan of the Company or any Subsidiary
               of the Company, or any trust or other entity organized,
               appointed, established or holding Common Stock for or
               pursuant to the terms of any such plan.

                    (l)  "Exercise Price" shall have the meaning set forth
               in Sections 4 and 7(b) hereof.

                    (m)  "Expiration Date" shall have the meaning set forth
               in Section 7(a) hereof.

                    (n)  "Fair Market Value" of any property shall mean the
               fair market value of such property as determined in
               accordance with Section 11(b) hereof.

                    (o)  "Final Expiration Date" shall have the meaning set
               forth in Section 7(a) hereof.

                    (p)  "Person" shall mean any individual, firm,
               corporation or other entity.

                    (q)  "Principal Party" shall have the meaning set forth
               in Section 13(b) hereof.

                    (r)  "Qualifying Tender Offer" shall mean a tender or
               exchange offer for all outstanding shares of Common Stock of
               the Company approved by a majority of the Board of Directors
               (provided, that at the time of such
                --------






































     
<PAGE>

<PAGE>
     

               approval of the Board of Directors there are then in office
               not less than two Continuing Directors and such offer is
               approved by a majority of the Continuing Directors then in
               office), after taking into account the potential long-term
               value of the Company and all other factors that they
               consider relevant.

                    (s)  "Redemption Price" shall have the meaning set
               forth in Section 23(a) hereof.

                    (t) "Right Certificate" shall have the meaning set
               forth in Section 3(d) hereof.

                    (u)  "Stock Acquisition Date" shall mean the first date
               on which there shall be a public announcement by the Company
               or an Acquiring Person that an Acquiring Person has become
               such (which, for purposes of this definition, shall include,
               without limitation, a report filed pursuant to Section 13(d)
               of the Exchange Act) or such earlier date as a majority of
               the Continuing Directors shall become aware of the existence
               of an Acquiring Person.

                    (v)  "Subsidiary" of a Person shall mean any
               corporation or other entity of which securities or other
               ownership interests having voting power sufficient to elect
               a majority of the board of directors or other persons
               performing similar functions are benefi-





































     
<PAGE>

<PAGE>
     

               cially owned, directly or indirectly, by such Person or by
               any corporation or other entity that is otherwise controlled
               by such Person.

                    (w)  "Summary of Rights" shall have the meaning set
               forth in Section 3(a) hereof.

                    (x)  "Trading Day" shall have the meaning set forth in
               Section 11(b) hereof.

                    (y)  "Transfer Tax" shall mean any tax or charge,
               including any documentary stamp tax, imposed or collected by
               any governmental or regulatory authority in respect of any
               transfer of any security, instrument or right, including
               Rights, shares of Common Stock and shares of Preferred
               Stock.

                    (z)  "Voting Stock" shall mean (i) the Common Stock of
               the Company and (ii) any other shares of capital stock of
               the Company entitled to vote generally in the election of
               directors or entitled to vote together with the Common Stock
               in respect of any merger, consolidation, sale of all or
               substantially all of the Company's assets, liquidation,
               dissolution or winding up.  For purposes of this Agreement,
               a stated percentage of the Voting Stock shall mean a number
               of shares of the Voting Stock as shall equal in voting power
               that stated percentage of the total voting power






































     
<PAGE>

<PAGE>
     

               of the then outstanding shares of Voting Stock in the
               election of a majority of the Board of Directors or in
               respect of any merger, consolidation, sale of all or
               substantially all of the Company's assets, liquidation,
               dissolution or winding up.

     Any determination required to be made by the Board of Directors of the
     Company for purposes of applying the definitions contained in this
     Section 1 shall be made by the Board of Directors in its good faith
     judgment, which determination shall be binding on the Rights Agent and
     the holders of the Rights.

               Section 2.  Appointment of Rights Agent.  The Company hereby
                           ---------------------------
     appoints the Rights Agent to act as agent for the Company and the
     holders of the Rights in accordance with the terms and conditions
     hereof, and the Rights Agent hereby accepts such appointment.  The
     Company may from time to time appoint such Co-Rights Agents as it may
     deem necessary or desirable.

               Section 3.  Issuance of Right Certificates.
                           ------------------------------
               (a)  On the Record Date (or as soon as practicable there-
     after), the Company or the Rights Agent shall send a copy of a Summary
     of Rights, in substantially the form attached hereto as Exhibit A (the
     "Summary of Rights"), by first class mail, postage prepaid, to each
     record holder of the Common Stock as of the close of business on the
     Record Date, at the address of such holder shown on the records of the
     Company.


































     
<PAGE>

<PAGE>
     

               (b)  Until the close of business on the day which is the
     earlier of (i) the tenth day after the Stock Acquisition Date or (ii)
     the tenth business day (or such later date as may be determined by
     action of the Board of Directors prior to such time as any Person
     becomes an Acquiring Person) after the date of the commencement by any
     Person (other than an Exempt Person) of, or the first public
     announcement of the intent of any Person (other than an Exempt Person)
     to commence, a tender or exchange offer upon the successful
     consummation of which such Person, together with its Affiliates and
     Associates, would be the Beneficial Owner of 30% or more of the then
     outstanding shares of Voting Stock of the Company (irrespective of
     whether any shares are actually purchased pursuant to any such offer)
     (the earlier of such dates being herein referred to as the
     "Distribution Date"), (x) the Rights shall be evidenced by the
     certificates for Common Stock registered in the name of the holders of
     Common Stock (together with, in the case of certificates for Common
     Stock outstanding as of the Record Date, the Summary of Rights) and
     not by separate Right certificates and the record holders of such
     certificates for Common Stock shall be the record holders of the
     Rights represented thereby and (y) each Right shall be transferable
     only simultaneously and together with the transfer of a share of
     Common Stock (subject to adjustment as hereinafter provided).  Until
     the Distribution Date (or, if earlier, the Expiration Date









































     
<PAGE>

<PAGE>
     

     or Final Expiration Date), the surrender for transfer of any
     certificate for Common Stock shall constitute the surrender for
     transfer of the Right or Rights associated with the Common Stock
     evidenced thereby, whether or not accompanied by a copy of the Summary
     of Rights.

               (c)  Rights shall be issued in respect of all shares of
     Common Stock that become outstanding after the Record Date but prior
     to the earlier of the Distribution Date, the Expiration Date or the
     Final Expiration Date and, in certain circumstances provided in
     Section 22 hereof, may be issued in respect of shares of Common Stock
     that become outstanding after the Distribution Date.  Certificates for
     Common Stock (including, without limitation, certificates issued upon
     original issuance, disposition from the Company's treasury or transfer
     or exchange of Common Stock) after the Record Date but prior to the
     earliest of the Distribution Date, the Expiration Date, or the Final
     Expiration Date (or, in certain circumstances as provided in
     Section 22 hereof, after the Distribution Date) shall have impressed,
     printed, written or stamped thereon or otherwise affixed thereto the
     following legend:

               This certificate also evidences and entitles the holder
          hereof to the same number of Rights (subject to adjustment)
          as the number of shares of Common Stock represented by this
          certificate, such Rights being on the terms provided under
          the Rights Agreement between U.S. Bioscience, Inc. and
          Chemical Mellon Shareholder Services L.L.C. (the "Rights
          Agent"), dated as of May 19, 1995, as it may be amended from
          time to time (the




























     
<PAGE>

<PAGE>
     

          "Rights Agreement"), the terms of which are incorporated herein
          by reference and a copy of which is on file at the principal
          executive offices of U.S. Bioscience, Inc.  Under certain
          circumstances, as set forth in the Rights Agreement, such Rights
          shall be evidenced by separate certificates and shall no longer
          be evidenced by this certificate.  U.S. Bioscience, Inc. shall
          mail to the registered holder of this certificate a copy of the
          Rights Agreement without charge within five days after receipt of
          a written request therefor.  Under certain circumstances as
                                       ------------------------------
          provided in Section 7(e) of the Rights Agreement, Rights issued
          ---------------------------------------------------------------
          to or Beneficially Owned by Acquiring Persons or their Affiliates
          -----------------------------------------------------------------
          or Associates (as such terms are defined in the Rights Agreement)
          -----------------------------------------------------------------
          or any subsequent holder of such Rights shall be null and void
          --------------------------------------------------------------
          and may not be transferred to any Person.
          ----------------------------------------

               (d)  As soon as practicable after the Distribution Date, the
     Company will prepare and execute, the Rights Agent will countersign,
     and the Company will send or cause to be sent (and the Rights Agent
     will, if requested, send), by first class mail, postage prepaid, to
     each record holder of the Common Stock as of the close of business on
     the Distribution Date, as shown by the records of the Company, at the
     address of such holder shown on such records, a certificate in the
     form provided by Section 4 hereof (a "Right Certificate"), evidencing
     one Right (subject to adjustment as provided herein) for each share of
     Common Stock so held.  As of and after the Distribution Date, the
     Rights shall be evidenced solely by Right Certificates and may be
     transferred by the transfer of the Right Certificate as permitted
     hereby, separately and apart from any transfer of one or more shares
     of Common Stock.





















<PAGE>

<PAGE>
     

               Section 4.  Form of Right Certificates.  The Right
                           --------------------------
     Certificates (and the forms of election to purchase shares, cer-
     tificate and assignment to be printed on the reverse thereof), when,
     as and if issued, shall be substantially in the form set forth in
     Exhibit B hereto and may have such marks of identification or
     designation and such legends, summaries or endorsements printed
     thereon as may be required to comply with any law or with any rule or
     regulation made pursuant thereto or with any rule or regulation of any
     stock exchange on which the Common Stock or the Rights may from time
     to time be listed or as the Company may deem appropriate to conform to
     usage or otherwise and as are not inconsistent with the provisions of
     this Rights Agreement.  Subject to the provisions of Section 22
     hereof, Right Certificates evidencing Rights whenever issued, (i)
     shall be dated as of the date of issuance of the Rights they represent
     and (ii) subject to adjustment from time to time as provided herein,
     on their face shall entitle the holders thereof to purchase such
     number of shares (including fractional shares which are integral
     multiples of one-hundredth of a share) of Preferred Stock as shall be
     set forth therein at the price payable upon exercise of a Right pro-
     vided by Section 7(b) hereof as the same may from time to time be
     adjusted as provided herein (the "Exercise Price").





































     
<PAGE>

<PAGE>
     

               Section 5.  Countersignature and Registration.
                           ---------------------------------
               (a)  Each Right Certificate shall be executed on behalf of
     the Company by its Chairman of the Board, President or any Vice
     President, either manually or by facsimile signature, and have affixed
     thereto the Company's seal or a facsimile thereof which shall be
     attested by the Secretary or an Assistant Secretary of the Company,
     either manually or by facsimile signature.  Each Right Certificate
     shall be countersigned by the Rights Agent either manually or by
     facsimile signature and shall not be valid for any purpose unless so
     countersigned.  In case any officer of the Company who shall have
     signed any Right Certificate shall cease to be such officer of the
     Company before countersignature by the Rights Agent and issuance and
     delivery of the certificate by the Company, such Right Certificate,
     nevertheless, may be countersigned by the Rights Agent and issued and
     delivered with the same force and effect as though the person who
     signed such Right Certificates had not ceased to be such officer of
     the Company.  Any Right Certificate may be signed on behalf of the
     Company by any person who, on the date of the execution of such Right
     Certificate, shall be a proper officer of the Company to sign such
     Right Certificate, although at the date of the execution of this
     Rights Agreement any such person was not such an officer.



































     
<PAGE>

<PAGE>
     

               (b)  Following the Distribution Date, the Rights Agent will
     keep or cause to be kept, at its principal office or one or more
     offices designated as the appropriate place for surrender of Right
     Certificates upon exercise or transfer, and in such other locations as
     may be required by law, books for registration and transfer of the
     Right Certificates issued hereunder.  Such books shall show the names
     and addresses of the respective holders of the Right Certificates, the
     number of Rights evidenced on its face by each of the Right
     Certificates and the date of each of the Right Certificates.

               Section 6.  Transfer, Split Up, Combination and Exchange of
                           -----------------------------------------------
     Right Certificates; Mutilated, Destroyed, Lost or Stolen Right
     --------------------------------------------------------------
     Certificates.
     ------------

               (a)  Subject to the provisions of Section 7(e), 7(f) and 14
     hereof, at any time after the Close of Business on the Distribution
     Date, and at or prior to the Close of Business on the earlier of the
     Expiration Date or the Final Expiration Date, any Right Certificate,
     may be (i) transferred or (ii) split up, combined or exchanged for one
     or more other Right Certificates, entitling the registered holder to
     purchase a like number of shares of Preferred Stock as the Right
     Certificate or Rights Certificates surrendered then entitled such
     holder to purchase.  Any registered holder desiring to transfer any
     Right Certificate shall surrender the Right Certificate at the office
     of the Rights










































     
<PAGE>

<PAGE>
     

     Agent designated for the surrender of Right Certificates with the form
     of certificate and assignment on the reverse side thereof duly
     endorsed (or enclosed with such Right Certificate a written instrument
     of transfer in form satisfactory to the Company and the Rights Agent),
     duly executed by the registered holder thereof or his attorney duly
     authorized in writing, and with such signature duly guaranteed.  Any
     registered holder desiring to split up, combine or exchange any Right
     Certificate shall make such request in writing delivered to the Rights
     Agent, and shall surrender the Right Certificate to be split up,
     combined or exchanged at the office of the Rights Agent designated
     therefor.  Thereupon, the Rights Agent shall countersign and deliver
     to the person entitled thereto a Right Certificate or Right
     Certificates, as the case may be, as so requested.  The Company may
     require payment of a sum sufficient to cover any Transfer Tax that may
     be imposed in connection with any transfer, split up, combination or
     exchange of any Right Certificates.

               (b)  Subject to the provisions of Section 7(e), 7(f) and 14
     hereof, upon receipt by the Company and the Rights Agent of evidence
     reasonably satisfactory to them of the loss, theft, destruction or
     mutilation of a Right Certificate, and, in case of loss, theft or
     destruction, of indemnity or security reasonably satisfactory to them
     and, if requested by the Company, reimbursement to the Company and the
     Rights Agent of all reasonable














































     
<PAGE>

<PAGE>
     

     expenses incidental thereto, or upon surrender to the Rights Agent and
     cancellation of the Right Certificate if mutilated, the Company shall
     issue and deliver a new Right Certificate of like tenor to the Rights
     Agent for delivery to the registered owner in lieu of the Right
     Certificate so lost, stolen, destroyed or mutilated.

               Section 7.  Exercise of Rights; Exercise Price; Expiration
                           ----------------------------------------------
     Date of Rights.
     --------------

               (a)  The Rights shall not be exercisable until, and shall
     become exercisable on, the Distribution Date (unless otherwise
     provided herein, including, without limitation, the restrictions on
     exercisability set forth in Section 7(e) and 23(a) hereof).  Except as
     otherwise provided herein, the Rights may be exercised, in whole or in
     part, at any time commencing with the Distribution Date upon surrender
     of the Right Certificate, with the form of election to purchase and
     certificate on the reverse side thereof duly executed (with signatures
     duly guaranteed), to the Rights Agent at the principal office of the
     Rights Agent in New York, New York, together with payment of the
     Exercise Price for each Right exercised, subject to adjustment as
     hereinafter provided, at or prior to the Close of Business on the
     earlier of (i) May 19, 2005 (the "Final Expiration Date") or (ii) the
     date on which the Rights are redeemed as provided in Section 23 hereof











































     
<PAGE>

<PAGE>
     

     (such earlier date being herein referred to as the "Expiration Date").

               (b)  The Exercise Price shall initially be $15 for each one
     one-hundredth (1/100) of a share of Preferred Stock issued pursuant to
     the exercise of a Right.  The Exercise Price and the number of shares
     of Preferred Stock or other securities to be acquired upon exercise of
     a Right shall be subject to adjustment from time to time as provided
     in Sections 11 and 13 hereof.  The Exercise Price shall be payable in
     lawful money of the United States of America, in accordance with
     paragraph (c) below.

               (c)  Except as otherwise provided herein, upon receipt of a
     Right Certificate representing exercisable Rights with the form of
     election to purchase duly executed, accompanied by payment by
     certified check, cashier's check, bank draft or money order payable to
     the Company or the Rights Agent of the Exercise Price for the shares
     to be purchased and an amount equal to any applicable Transfer Tax
     required to be paid by the holder of the Right Certificate in
     accordance with Section 9(e) hereof, the Rights Agent shall thereupon
     promptly (i) requisition from any transfer agent of the Preferred
     Stock of the Company one or more certificates representing the number
     of shares of Preferred Stock to be so purchased, and the Company
     hereby authorizes and directs such transfer agent to comply with all
     such requests, (ii) as provided in Section 14(b), at the election of
     the Company, cause













































     
<PAGE>

<PAGE>
     

     depositary receipts to be issued in lieu of fractional shares of
     Preferred Stock, (iii) if the election provided for in the immediately
     preceding clause (ii) has not been made, requisition from the Company
     the amount of cash to be paid in lieu of the issuance of fractional
     shares in accordance with Section 14(b) hereof, (iv) after receipt of
     such Preferred Stock certificates and, if applicable, depositary
     receipts, cause the same to be delivered to or upon the order of the
     registered holder of such Right Certificate, registered in such name
     or names as may be designated by such holder and (v) when appropriate,
     after receipt, promptly deliver such cash to or upon the order of the
     registered holder of such Right Certificate; provided, however, that
                                                  --------  -------
     in the case of a purchase of securities, other than Preferred Stock,
     pursuant to Section 13 hereof, the Rights Agent shall promptly take
     the appropriate actions corresponding in such case to that referred to
     in the foregoing clauses (i) through (v) of this Section 7(c). 
     Notwithstanding the foregoing provisions of this Section 7(c), the
     Company may suspend the issuance of shares of Preferred Stock upon
     exercise of a Right for a reasonable period, not in excess of 90 days,
     during which the Company seeks to register under the Securities Act of
     1933, as amended (the "Act"), and any applicable securities law of any
     other jurisdiction, the shares of Preferred Stock to be issued
     pursuant to the Rights; provided, however, that nothing contained in
                             --------  -------
     this












































     
<PAGE>

<PAGE>
     

     Section 7(c) shall relieve the Company of its obligations under
     Section 9(c) hereof.

               (d)  In case the registered holder of any Right Certificate
     shall exercise less than all the Rights evidenced thereby, a new Right
     Certificate evidencing Rights equivalent to the Rights remaining
     unexercised shall be issued by the Rights Agent to the registered
     holder of such Right Certificate or his assign, subject to the
     provisions of Section 14(b) hereof.

               (e)  Notwithstanding any provision of this Rights Agreement
     to the contrary, from and after the time (the "invalidation time")
     when any Person first becomes an Acquiring Person, other than pursuant
     to a Qualifying Tender Offer, any Rights that are beneficially owned
     by (x) such Acquiring Person (or any Associate or Affiliate of such
     Acquiring Person), (y) a transferee of such Acquiring Person (or any
     such Associate or Affiliate) who becomes a transferee after the
     invalidation time or (z) a transferee of such Acquiring Person (or any
     such Associate or Affiliate) who becomes a transferee prior to or
     concurrently with the invalidation time pursuant to either (I) a
     transfer from the Acquiring Person to holders of its equity securities
     or to any Person with whom it has any continuing agreement,
     arrangement or understanding regarding the transferred Rights or (II)
     a transfer which the Board of Directors has determined is part of a
     plan, arrangement or understanding which has



































     
<PAGE>

<PAGE>
     

     the purpose or effect of avoiding the provisions of this Section 7(e),
     and subsequent transferees of such Persons referred to in clause (y)
     and (z) above, shall be void without any further action and any holder
     of such Rights shall thereafter have no rights whatsoever with respect
     to such Rights under any provision of this Rights Agreement.  The
     Company shall use all reasonable efforts to ensure that the provisions
     of this Section 7(e) are complied with, but shall have no liability to
     any holder of Right Certificates or any other Person as a result of
     its failure to make any determination with respect to an Acquiring
     Person or its Affiliates, Associates or transferees hereunder.  No
     Right Certificate shall be issued pursuant to Section 3 hereof that
     represents Rights beneficially owned by an Acquiring Person whose
     Rights would be void pursuant to the provisions of this Section 7(e)
     or any Associate or Affiliate thereof; no Right Certificate shall be
     issued at any time upon the transfer of any Rights to an Acquiring
     Person whose Rights would be void pursuant to the provisions of this
     Section 7(e) or any Associate or Affiliate thereof or to any nominee
     of such Acquiring Person, Associate or Affiliate; and any Right
     Certificate delivered to the Rights Agent for transfer to an Acquiring
     Person whose Rights would be void pursuant to the provisions of this
     Section 7(e) shall be cancelled.





















































     
<PAGE>

<PAGE>
     

               (f)  Notwithstanding anything in this Agreement to the
     contrary, neither the Rights Agent nor the Company shall be obligated
     to undertake any action with respect to a registered holder upon the
     occurrence of any purported exercise as set forth in this Section 7
     unless such registered holder shall have (i) completed and signed the
     certificate following the form of election to purchase set forth on
     the reverse side of the Right Certificate surrendered for such
     exercise and (ii) provided such additional evidence of the identity of
     the Beneficial Owner (or former Beneficial Owner) or Affiliates or
     Associates thereof as the Company shall reasonably request.

               Section 8.  Cancellation and Destruction of Right
                           -------------------------------------
     Certificates.  All Right Certificates surrendered for the purpose of
     ------------
     exercise, transfer, split up, combination or exchange shall, if
     surrendered to the Company or to any of its agents, be delivered to
     the Rights Agent for cancellation or in cancelled form, or, if
     surrendered to the Rights Agent, shall be cancelled by it, and no
     Right Certificates shall be issued in lieu thereof except as expressly
     permitted by any of the provisions of this Rights Agreement.  The
     Company shall deliver to the Rights Agent for cancellation and
     retirement, and the Rights Agent shall cancel and retire, any Right
     Certificate purchased or acquired by the Company otherwise than upon
     the exercise thereof.  The Rights Agent shall deliver all cancelled
     Right Certificates to the































     
<PAGE>

<PAGE>
     

     Company, or shall, at the written request of the Company, destroy such
     cancelled Right Certificates, and in such case shall deliver a
     certificate of destruction thereof to the Company.

               Section 9.  Reservation and Availability of Shares of
                           -----------------------------------------
     Preferred Stock.
     ---------------

               (a)  The Company covenants and agrees that it will cause to
     be reserved and kept available out of its authorized and unissued
     shares of Preferred Stock or out of authorized and issued shares of
     Preferred Stock held in its treasury, such number of shares of
     Preferred Stock as will from time to time be sufficient to permit the
     exercise in full of all outstanding Rights.

               (b)  The Company shall use its best efforts to cause, from
     and after such time as the Rights become exercisable, all shares of
     Preferred Stock issued or reserved for issuance in accordance with
     this Rights Agreement to be listed, upon official notice of issuance,
     upon the principal national securities exchange, if any, upon which
     the Common Stock is listed or, if the principal market for the Common
     Stock is not on any national securities exchange, to be eligible for
     quotation in the National Association of Securities Dealers' Automated
     Quotation System or any successor thereto or other comparable
     quotation system.

               (c)  The Company covenants and agrees that it will take all
     such action as may be necessary to insure that all shares of






























     
<PAGE>

<PAGE>
     

     Preferred Stock delivered upon exercise of Rights shall, at the time
     of delivery of the certificates for such shares (subject to payment of
     the Exercise Price in respect thereof), be duly and validly authorized
     and issued and fully paid and nonassessable shares.

               (d)  The Company shall use its best efforts to (i) file, as
     soon as practicable following the occurrence of the event described in
     Section 11(a)(ii), or as soon as is required by law following the
     Distribution Date, as the case may be, a registration statement under
     the Act, with respect to the shares of Preferred Stock purchasable
     upon exercise of the Rights on an appropriate form, (ii) cause such
     registration statement to become effective as soon as practicable
     after such filing, and (iii) cause such registration statement to
     remain effective (with a prospectus at all times meeting the
     requirements of the Act) until the earlier of (A) the date as of which
     the Rights are no longer exercisable for Preferred Stock, and (b) the
     date of the expiration of the Rights.  The Company may temporarily
     suspend, for a period of time not to exceed ninety days, the issuance
     of shares of Preferred Stock upon exercise of a Right in order to
     prepare and file a registration statement under the Act and permit it
     to become effective.  The Company will also take such action as may be
     appropriate under, or to ensure compliance with, the securities or
     "blue sky" laws of the various states in con-














































     
<PAGE>

<PAGE>
     

     nection with the exercisability of the Rights.  Notwithstanding any
     provision of this Agreement to the contrary, the Rights shall not be
     exercisable in any jurisdiction unless the requisite qualification in
     such jurisdiction shall have been obtained and until a registration
     statement under the Act (if required) shall have been declared
     effective.

               (e)  The Company covenants and agrees that it will pay when
     due and payable any and all federal and state Transfer Taxes which may
     be payable in respect of the issuance or delivery of the Right
     Certificates or of any shares of Preferred Stock issued or delivered
     upon the exercise of Rights.  The Company shall not, however, be
     required to pay any Transfer Tax which may be payable in respect of
     any transfer or delivery of a Right Certificate to a Person other
     than, or the issuance or delivery of certificates for Preferred Stock
     upon exercise of Rights in a name other than that of, the registered
     holder of the Right Certificate, and the Company shall not be required
     to issue or deliver a Right Certificate or certificate for Preferred
     Stock to a Person other than such registered holder until any such
     Transfer Tax shall have been paid (any such Transfer Tax being payable
     by the holder of such Right Certificate at the time of surrender) or
     until it has been established to the Company's satisfaction that no
     such Transfer Tax is due.










































     
<PAGE>

<PAGE>
     

               Section 10.  Preferred Stock Record Date.  Each Person in
                            ---------------------------
     whose name any certificate for shares of Preferred Stock is issued
     upon the exercise of Rights shall for all purposes be deemed to have
     become the holder of record of the Preferred Stock represented thereby
     on, and such certificate shall be dated as of, the date upon which the
     Right Certificate evidencing such Rights was duly surrendered and
     payment of the Exercise Price (and any applicable Transfer Taxes) was
     made; provided, however, that, if the date of such surrender and
           --------  -------
     payment is a date upon which the Preferred Stock transfer books of the
     Company are closed, such Person shall be deemed to have become the
     record holder of such shares on, and such certificate shall be dated
     as of, the next succeeding Business Day on which the Preferred Stock
     transfer books of the Company are open.  Prior to the exercise of the
     Rights evidenced thereby, the holder of a Right Certificate, as such,
     shall not be entitled to any rights of a stockholder of the Company
     with respect to shares for which the Rights shall be exercisable,
     including, without limitation, the right to vote, to receive dividends
     or other distributions or to exercise any preemptive rights, and shall
     not be entitled to receive any notice of any proceedings of the
     Company, except as provided herein.

               Section 11.  Adjustment of Exercise Price or Number of
                            -----------------------------------------
     Shares.  The Exercise Price and the number of shares of Preferred
     ------



























<PAGE>

<PAGE>
     


     Stock which may be purchased upon exercise of a Right are subject to
     adjustment from time to time as provided in this Section 11.

                    (a)  (i)  In the event the Company shall at any time
               after the date of this Rights Agreement (A) declare or pay
               any dividend on Common Stock payable in shares of Common
               Stock, (B) subdivide or split the outstanding shares of
               Common Stock into a greater number of shares or (C) combine
               or consolidate the outstanding shares of Common Stock into a
               smaller number of shares or effect a reverse split of the
               outstanding shares of Common Stock, then and in each such
               event the number of shares of Preferred Stock issuable upon
               the exercise of a Right after the record date for such event
               (if one shall have been established or, if not, after the
               date of such event) shall be the number of shares of
               Preferred Stock issuable immediately prior to such event
               multiplied by a fraction the numerator of which is the
               number of Rights outstanding immediately prior to such event
               and the denominator of which is the number of Rights
               outstanding immediately after such event and the Exercise
               Price after such event shall be the Exercise Price in effect
               immediately prior to such event multiplied by such fraction. 
               If an event occurs which would require an adjustment under

































     
<PAGE>

<PAGE>
     

               both this Section 11(a)(i) and Section 11(a)(ii) hereof, the
               adjustment provided for in this Section 11(a)(i) shall be in
               addition to, and shall be made prior to, any adjustment
               required pursuant to Section 11(a)(ii).

                    (ii)  In the event that any Person (other than an
               Exempt Person), alone or together with its Affiliates and
               Associates, shall become an Acquiring Person, except
               pursuant to a Qualifying Tender Offer, then, subject to the
               last sentence of Section 23(a) and except as otherwise
               provided in this Section 11, each holder of a Right, except
               as provided in Section 7(e) hereof, shall thereafter have
               the right to receive upon exercise of such Right in
               accordance with the terms of this Rights Agreement and
               payment of the Exercise Price, the greater of (1) the number
               of one one-hundredths of a share of Preferred Stock for
               which such Right was exercisable immediately prior to the
               first occurrence of the event described in this Section
               11(a)(ii) or (2) such number of one one-hundredths of a
               share of Preferred Stock, based on the per share Fair Market
               Value of the Preferred Stock (determined pursuant to Section
               11(b) hereof) on the date of such first occurrence, having a
               value equal to twice the Exercise

































     
<PAGE>

<PAGE>
     

               Price; provided, however, that if the transaction that would
                      --------  -------
               otherwise give rise to the foregoing adjustment is also
               subject to the provisions of Section 13 hereof, then only
               the provisions of Section 13 hereof shall apply and no
               adjustment shall be made pursuant to this Section 11(a)(ii).

                    (iii)  In the event that the Company does not have
               available sufficient authorized but unissued Preferred Stock
               to permit the adjustments required pursuant to the foregoing
               subparagraph (i) or the exercise in full of the Rights in
               accordance with the foregoing subparagraph (ii), the Company
               shall take all such action as may be necessary to authorize
               and reserve for issuance such number of additional shares of
               Preferred Stock as may from time to time be required to be
               issued upon the exercise in full of all Rights from time to
               time outstanding and, if necessary, shall use its best
               efforts to obtain stockholder approval thereof.  In lieu of
               issuing shares of Preferred Stock in accordance with the
               foregoing subparagraphs (i) and (ii), the Company may, if
               the Board of Directors determines (but only if at the time
               of such determination by the Board of Directors there are
               then in office not less than two Continuing Directors and
               such action is approved by a
































     
<PAGE>

<PAGE>
     

               majority of the Continuing Directors then in office) that
               such action is necessary or appropriate and not contrary to
               the interests of holders of Rights, elect to issue or pay,
               upon the exercise of the Rights, cash, property, shares of
               Preferred or Common Stock, or any combination thereof,
               having an aggregate Fair Market Value equal to the Fair
               Market Value of the shares of Preferred Stock which
               otherwise would have been issuable pursuant to Section
               11(a)(ii), which Fair Market Value shall be determined by an
               investment banking firm selected by the Board of Directors
               (but only if at the time of such selection there are then in
               office not less than two Continuing Directors and such
               selection is approved by a majority of the Continuing
               Directors then in office).  For purposes of the preceding
               sentence, the Fair Market Value of the Preferred Stock shall
               be as determined pursuant to Section 11(b).  Subject to
               Section 23 hereof, any such election by the Board of
               Directors of the Company must be made and publicly announced
               within thirty (30) days after the date on which the event
               described in Section 11(a)(ii) occurs.

               (b)  For the purpose of this Rights Agreement, the "Fair
     Market Value" of any share of Preferred Stock, Common Stock































     
<PAGE>

<PAGE>
     

     or any other stock or any Right or other security or any other
     property on any date shall be determined as provided in this Section
     11(b).  In the case of a publicly-traded stock or other security, the
     Fair Market Value on any date shall be deemed to be the average of the
     daily closing prices per share of such stock or per unit of such other
     security for the 30 consecutive Trading Days (as such term is
     hereinafter defined) immediately prior to such date; provided,
                                                          --------
     however, that in the event that the Fair Market Value per share of any
     -------
     share of Common Stock is determined during a period which includes any
     date that is within 30 Trading Days after (i) the ex-dividend date for
     a dividend or distribution on such stock payable in shares of Common
     Stock or securities convertible into shares of Common Stock, or (ii)
     the effective date of any subdivision, split, combination,
     consolidation, reverse stock split or reclassification of such stock,
     then, and in each such case, the Fair Market Value shall be
     appropriately adjusted by the Board of Directors of the Company to
     take into account ex-dividend or post-effective date trading.  The
     closing price for any day shall be the last sale price, regular way,
     or, in case no such sale takes place on such day, the average of the
     closing bid and asked prices, regular way (in either case, as reported
     in the applicable transaction reporting system with respect to
     securities listed or admitted to trading on the New York Stock
     Exchange), or, if the securities are not listed or

































     
<PAGE>

<PAGE>
     

     admitted to trading on the New York Stock Exchange, as reported in the
     applicable transaction reporting system with respect to securities
     listed on the principal national securities exchange on which such
     security is listed or admitted to trading; or, if not listed or
     admitted to trading on any national securities exchange, the last
     quoted price (or, if not so quoted, the average of the high bid and
     low asked prices) in the over-the-counter market, as reported by the
     National Association of Securities Dealers, Inc. Automated Quotation
     System ("NASDAQ") or such other system then in use; or, if no bids for
     such security are quoted by any such organization, the average of the
     closing bid and asked prices as furnished by a professional market
     maker making a market in such security selected by the Board of
     Directors of the Company.  The term "Trading Day" shall mean a day on
     which the principal national securities exchange on which such
     security is listed or admitted to trading is open for the transaction
     of business or, if such security is not listed or admitted to trading
     on any national securities exchange, a Business Day.  If a security is
     not publicly held or not so listed or traded, "Fair Market Value"
     shall mean the fair value per share of stock or per other unit of such
     other security, as determined by an independent investment banking
     firm experienced in the valuation of securities selected in good faith
     by the Board of Directors of the Company, or, if no such investment














































     
<PAGE>

<PAGE>
     

     banking firm is, in the good faith judgment of the Board of Directors,
     available to make such determination, in good faith by the Board of
     Directors of the Company; provided, however, that for purposes of
                               --------  -------
     making the adjustment provided for by Section 11(a)(ii) hereof, the
     Fair Market Value of a share of Preferred Stock shall not be less than
     100% of the product of the Fair Market Value of a share of Common
     Stock multiplied by the higher of the then Dividend Multiple or Vote
     Multiple applicable to the Preferred Stock (as defined in the
     Certificate of Designations relating to the Preferred Stock) and shall
     not exceed 105% of the product of the then Fair Market Value of a
     share of Common Stock multiplied by the higher of the then Dividend
     Multiple or Vote Multiple applicable to the Preferred Stock.  In the
     case of property other than securities, the "Fair Market Value"
     thereof shall be determined in good faith by the Board of Directors of
     the Company based upon such appraisals or valuation reports of such
     independent experts as the Board of Directors of the Company shall in
     good faith determine to be appropriate in accordance with good
     business practices and the interests of the holders of Rights.  Any
     such determination of Fair Market Value shall be described in a
     statement filed with the Rights Agent and shall be binding upon the
     Rights Agent.











































     
<PAGE>

<PAGE>
     

               (c)  All calculations under this Section 11 shall be made to
     the nearest cent or to the nearest one one-hundredth of a share, as
     the case may be.

               (d)  Irrespective of any adjustment or change in the
     Exercise Price or the number of shares of Preferred Stock issuable
     upon the exercise of the Rights, the Right Certificates theretofore
     and thereafter issued may continue to express the Exercise Price and
     the number of shares to be issued upon exercise of the Rights as in
     the initial Right Certificates issued hereunder but, nevertheless,
     shall represent the Rights as so adjusted.

               (e)  Before taking any action that would cause an adjustment
     reducing the purchase price per whole share of Preferred Stock upon
     exercise of the Rights below the then par value, if any, of the shares
     of Preferred Stock, the Company shall use its best efforts to take any
     corporate action which may, in the opinion of its counsel, be
     necessary in order that the Company may validly and legally issue
     fully paid and non-assessable shares of such Preferred Stock at such
     adjusted purchase price per share.

               (f)  Anything in this Section 11 to the contrary
     notwithstanding, in the event of any reclassification of stock of the
     Company or any recapitalization, reorganization or partial liquidation
     of the Company or similar transaction, the Company





















     
<PAGE>

<PAGE>
     

     shall be entitled to make such further adjustments in the number of
     shares of Preferred Stock which may be acquired upon exercise of the
     Rights, and such adjustments in the Exercise Price therefor, in
     addition to those adjustments expressly required by the other
     paragraphs of this Section 11, as the Board of Directors of the
     Company shall determine to be necessary or appropriate in order for
     the holders of the Rights in such event to be treated equitably and in
     accordance with the purpose and intent of this Rights Agreement or in
     order that any such event shall not, but for such adjustment, in the
     opinion of counsel to the Company, result in the stockholders of the
     Company being subject to any United States federal income tax
     liability by reason thereof.

               (g)  In the event the Company shall at any time after the
     Record Date make any distribution on the shares of Common Stock of the
     Company, whether by way of a dividend or a reclassification of stock,
     a recapitalization, reorganization or partial liquidation of the
     Company or otherwise, in cash or any debt security, debt instrument,
     real or personal property or any other property (other than any shares
     of Common Stock or other capital stock of the Company and other than
     any right or warrant to acquire any such shares, including any debt
     security convertible into or exchangeable for any such share, at less
     than the Fair Market Value of such shares) and the amount of such cash
     dividend or the Fair Market Value of such debt security, debt
     instrument












































     
<PAGE>

<PAGE>
     

     or property exceeds 150% of the aggregate amount of the cash dividends
     declared or paid on the Common Stock of the Company in the 15-month
     period immediately preceding such distribution, then and in each such
     event, unless such distribution is part of or is made in connection
     with a transaction to which Section 11(a)(ii) or Section 13 hereof
     applies, the Exercise Price shall be reduced by an amount equal to the
     cash or the Fair Market Value of such distribution, as the case may
     be, per share of Common Stock of the Company.  For purposes hereof,
     the Fair Market Value of any property distributed to the holders of
     shares of Common Stock of the Company shall be the Fair Market Value
     of such property as determined by an independent investment banking
     firm experienced in the valuation of securities or the other property
     so distributed, as the case may be, selected in good faith by the
     Board of Directors of the Company, or, if no such investment banking
     firm is in the good faith judgment of the Board of Directors available
     to make such determination, in good faith by the Board of Directors of
     the Company, whose determination shall be final and binding on the
     Company, the Rights Agent and the holders of Rights.

               Section 12.  Certification of Adjusted Exercise Price or
                            -------------------------------------------
     Number of Shares.  Whenever an adjustment is made as provided in
     ----------------
     Section 11, 13 or 23(c), the Company shall (a) promptly prepare a
     certificate setting forth such adjustment, and a brief











































     
<PAGE>

<PAGE>
     

     statement of the facts giving rise to such adjustment, (b) promptly
     file with the Rights Agent and with each transfer agent for the
     Preferred Stock a copy of such certificate and (c) mail a brief
     summary thereof to each holder of a Right Certificate in accordance
     with Section 25.  Notwithstanding the foregoing sentence, the failure
     of the Company to make such certification or give such notice shall
     not affect the validity of or the force or effect of the requirement
     for such adjustment.  Any adjustment to be made pursuant to Section
     11, 13 or 23(c) of this Rights Agreement shall be effective as of the
     date of the event giving rise to such adjustment.  The Rights Agent
     shall be fully protected in relying on any such certificate and on any
     adjustment therein contained and shall not be deemed to have knowledge
     of any adjustment unless and until it shall have received such
     certificate.

               Section 13.  Consolidation, Merger or Sale or Transfer of
                            --------------------------------------------
     Assets or Earning Power.
     -----------------------

                (a)  Except for any transaction approved by the Board of
     Directors (but only if at the time of such approval by the Board of
     Directors there are then in office not less than two Continuing
     Directors and such action is approved by a majority of the Continuing
     Directors then in office), in the event that, at any time on or after
     the Distribution Date, (x) the Company shall, directly or indirectly,
     consolidate with, or merge with
























     
<PAGE>

<PAGE>
     

     and into, any other Person or Persons (other than an Exempt Person)
     and the Company shall not be the surviving or continuing corporation
     of such consolidation or merger, or (y) any Person or Persons (other
     than an Exempt Person) shall, directly or indirectly, consolidate
     with, or merge with and into, the Company, and the Company shall be
     the continuing or surviving corporation of such consolidation or
     merger and, in connection with such consolidation or merger, all or
     part of the outstanding shares of Common Stock shall be changed into
     or exchanged for stock or other securities of any other Person (other
     than an Exempt Person) or of the Company or cash or any other
     property, or (z) the Company or one or more of its Subsidiaries shall,
     directly or indirectly, sell or otherwise transfer to any other Person
     or any Affiliate or Associate of such Person, in one or more
     transactions, or the Company or one or more of its Subsidiaries shall
     sell or otherwise transfer to any Persons in one or a series of
     related transactions, assets or earning power aggregating more than
     50% of the assets or earning power of the Company and its Subsidiaries
     (taken as a whole), then, on the first occurrence of any such event,
     proper provision shall be made so that (i) each holder of record of a
     Right, except as provided in Section 7(e) hereof, shall thereafter
     have the right to receive, upon the exercise thereof and payment of
     the Exercise Price in accordance with the terms of this Rights
     Agreement, such



















































     
<PAGE>

<PAGE>
     

     number of shares of validly issued, fully paid, non-assessable and
     freely tradeable Common Stock of the Principal Party (as defined
     herein), not subject to any liens, encumbrances, rights of first
     refusal or other adverse claims, as shall, based on the Fair Market
     Value of the Common Stock of the Principal Party on the date of the
     Consummation of such consolidation, merger, sale or transfer, equal
     twice the Exercise Price; (ii) such Principal Party shall thereafter
     be liable for, and shall assume, by virtue of such consolidation,
     merger, sale or transfer, all the obligations and duties of the
     Company pursuant to this Rights Agreement; (iii) the term "Company"
     for all purposes of this Rights Agreement shall thereafter be deemed
     to refer to such Principal Party; (iv) such Principal Party shall take
     such steps (including, but not limited to, the reservation of a
     sufficient number of shares of its Common Stock in accordance with the
     provisions of Section 9 hereof applicable to the reservation of
     Preferred Stock) in connection with such consummation as may be
     necessary to assure that the provisions hereof shall thereafter be
     applicable, as nearly as reasonably may be, in relation to its shares
     of Common Stock thereafter deliverable upon the exercise of the
     Rights; provided, however, that, upon the subsequent occurrence of any
             --------  -------
     merger, consolidation, sale of all or substantially all of the assets,
     recapitalization, reclassification of shares, reorganization or other
     extraordinary transaction in



































     
<PAGE>

<PAGE>
     

     respect of such Principal Party, each holder of a Right shall
     thereupon be entitled to receive, upon exercise of a Right and payment
     of the Exercise Price, such cash, shares, rights, warrants and other
     property which such holder would have been entitled to receive had it,
     at the time of such transaction, owned the shares of Common Stock of
     the Principal Party purchasable upon the exercise of a Right, and such
     Principal Party shall take such steps (including, but not limited to,
     reservation of shares of stock) as may be necessary to permit the
     subsequent exercise of the Rights in accordance with the terms hereof
     for such cash, shares, rights, warrants and other property and (v) the
     provisions of Section 11(a)(ii) hereof shall be of no effect following
     the occurrence of any event described in clause (x), (y) or (z) above
     of this Section 13(a).

               (b)  "Principal Party" shall mean

                    (i)  in the case of any transaction described in (x) or
     (y) of the first sentence of Section 13(a) hereof:  (A) the Person
     that is the issuer of the securities into which shares of Common Stock
     of the Company are changed or otherwise exchanged or converted in such
     merger or consolidation, or, if there is more than one such issuer,
     the issuer of the Common Stock of which has the greatest market value
     or (B) if no securities are so issued, (x) the Person that is the
     other party to the merger or consolidation and that survives such
     merger or













































     
<PAGE>

<PAGE>
     

     consolidation, or, if there is more than one such Person, the Person
     the Common Stock of which has the greatest market value or (y) if the
     Person that is the other party to the merger or consolidation does not
     survive the merger or consolidation, the Person that does survive the
     merger or consolidation (including the Company if it survives); and

                   (ii)  in the case of any transaction described in (z) of
     the first sentence in Section 13(a), the Person that is the party
     receiving the greatest portion of the assets or earning power
     transferred pursuant to such transaction or transactions, or, if each
     Person that is a party to such transaction or transactions receives
     the same portion of the assets or earning power so transferred or if
     the Person receiving the greatest portion of the assets or earning
     power cannot be determined, whichever of such Persons as is the issuer
     of Common Stock having the greatest market value of shares
     outstanding; provided, however, that in any such case, if the Common
                  --------  -------
     Stock of such Person is not at such time and has not been continuously
     over the preceding 12-month period registered under Section 12 of the
     Exchange Act, and such Person is a direct or indirect Subsidiary of
     another Person the Common Stock of which is and has been so
     registered, the term "Principal Party" shall refer to such other
     Person, or if such Person is a Subsidiary, directly or indirectly, of
     more than one Person, the Common Stocks of all of which are and have
     been so













































     
<PAGE>

<PAGE>
     

     registered, the term "Principal Party" shall refer to whichever of
     such Persons is the issuer of the Common Stock having the greatest
     market value of shares outstanding.

               (c)  The Company shall not consummate any consolidation,
     merger or sale or transfer of assets or earning power referred to in
     Section 13(a) unless the Principal Party shall have a sufficient
     number of authorized shares of its Common Stock that have not been
     issued or reserved for issuance to permit exercise in full of all
     Rights in accordance with this Section 13 and unless prior thereto the
     Company and the Principal Party involved therein shall have executed
     and delivered to the Rights Agent an agreement confirming that the
     Principal Party shall, upon consummation of such consolidation, merger
     or sale or transfer of assets or earning power, assume this Rights
     Agreement in accordance with Section 13(a) hereof and that all rights
     of first refusal or preemptive rights in respect of the issuance of
     shares of Common Stock of the Principal Party upon exercise of
     outstanding Rights have been waived and that such transaction shall
     not result in a default by the Principal Party under this Rights
     Agreement, and further providing that, as soon as practicable after
     the date of any consolidation, merger or sale or transfer of assets or
     earning power referred to in Section 13(a) hereof, the Principal Party
     will:























     
<PAGE>

<PAGE>
     

                    (i)  prepare and file a registration statement under
               the Act with respect to the Rights and the securities
               purchasable upon exercise of the Rights on an appropriate
               form, use its best efforts to cause such registration
               statement to become effective as soon as practicable after
               such filing and use its best efforts to cause such
               registration statement to remain effective (with a
               prospectus at all times meeting the requirements of the Act)
               until the date of expiration of the Rights, and similarly
               comply with applicable state securities laws;

                    (ii)  use its best efforts to list (or continue the
               listing of) the Rights and the securities purchasable upon
               exercise of the Rights on a national securities exchange or
               to meet the eligibility requirements for quotation on
               NASDAQ; and

                    (iii)  deliver to holders of the Rights historical
               financial statements for the Principal Party which comply in
               all respects with the requirements for registration on Form
               10 (or any successor form) under the Exchange Act.  In the
               event that any of the transactions described in Section
               13(a) hereof shall occur at any time after the occurrence of
               a transaction described in Section 11(a)(ii) hereof, the
               Rights which




















     
<PAGE>

<PAGE>
     

               have not theretofore been exercised shall, subject to the
               provisions of Section 7(e) hereof, thereafter be exercisable
               in the manner described in Section 13(a).

               (d)  In case the Principal Party which is to be a party to a
     transaction referred to in this Section 13 has a provision in any of
     its authorized securities or in its Certificate of Incorporation or
     By-laws or other instrument governing its corporate affairs, which
     provision would have the effect of (i) causing such Principal Party to
     issue, in connection with, or as a consequence of, the consummation of
     a transaction referred to in this Section 13, shares of Common Stock
     of such Principal Party at less than the then Fair Market Value per
     share (determined pursuant to Section 11(b) hereof) or securities
     exercisable for, or convertible into, Common Stock of such Principal
     Party at less than such then Fair Market Value (other than to holders
     of Rights pursuant to this Section 13) or (ii) providing for any
     special tax or similar payment in connection with the issuance to any
     holder of a Right of Common Stock of such Principal Party pursuant to
     the provisions of this Section 13, then, in such event, the Company
     shall not consummate any such transaction unless prior thereto the
     Company and such Principal Party shall have executed and delivered to
     the Rights Agent a supplemental agreement providing that the provision
     in question of such Principal Party shall have been canceled, waived
     or amended, or






















     
<PAGE>

<PAGE>
     

     that the authorized securities shall be redeemed, so that the
     applicable provision will have no effect in connection with, or as a
     consequence of, the consummation of the proposed transaction.

               Section 14.  Fractional Rights and Fractional Shares.
                            ---------------------------------------

               (a)  The Company shall not be required to issue fractions of
     Rights or to distribute Right Certificates which evidence fractional
     Rights (i.e., Rights to acquire less than one one-hundredth of a share
             ----
     of Preferred Stock), unless such fractional Rights result from a
     transaction referred to in Section 11(a)(i) hereof.  If the Company
     shall determine not to issue such fractional Rights, then, in lieu of
     such fractional Rights, there shall be paid to the holders of record
     of the Right Certificates with regard to which such fractional Rights
     would otherwise be issuable, an amount in cash equal to the same
     fraction of the Fair Market Value of a whole Right.

               (b)  The Company shall not be required to issue fractions of
     shares of Preferred Stock (other than fractions which are integral
     multiples of one-hundredth of a share) upon exercise of the Rights or
     to distribute certificates which evidence fractional shares (other
     than fractions which are integral multiples of one-hundredth of a
     share).  In lieu of issuing fractions of shares of Preferred Stock,
     the Company may, at its election, issue depositary receipts evidencing
     fractions




























     
<PAGE>

<PAGE>
     

     of shares pursuant to an appropriate agreement between the Company and
     a depositary selected by it, provided that such agreement shall
                                  --------
     provide that the holders of such depositary receipts shall have all of
     the rights, privileges and preferences to which they would be entitled
     as owners of the Preferred Stock.  With respect to fractional shares
     that are not integral multiples of one-hundredth of a share, if the
     Company does not issue such fractional shares or depositary receipts
     in lieu thereof, there shall be paid to the holders of record of Right
     Certificates at the time such Right Certificates are exercised as
     herein provided an amount in cash equal to the same fraction of the
     Fair Market Value of a share of Preferred Stock.

               (c)  The holder of a Right by the acceptance of a Right
     expressly waives his right to receive any fractional Right or any
     fractional shares of Preferred Stock (other than fractions which are
     integral multiples of one one-hundredth of a share) upon exercise of a
     Right.

               Section 15.  Rights of Action.  All rights of action in
                            ----------------
     respect of this Rights Agreement, except the rights of action given to
     the Rights Agent in Section 18 hereof, are vested in the respective
     registered holders of the Right Certificates (and, prior to the
     Distribution Date, the holders of record of the Common Stock); and any
     holder of record of any Right Certificate (or, prior to the
     Distribution Date, of the Common Stock),



















     
<PAGE>

<PAGE>
     

     without the consent of the Rights Agent or of the holder of any other
     Right Certificate (or, prior to the Distribution Date, of the Common
     Stock), may, in his own behalf and for his own benefit, enforce, and
     may institute and maintain any suit, action or proceeding against the
     Company to enforce, or otherwise act in respect of, his right to
     exercise the Rights evidenced by such Right Certificate in the manner
     provided in such Right Certificate and in this Rights Agreement. 
     Without limiting the foregoing or any remedies available to the
     holders of Rights, it is specifically acknowledged that the holders of
     Rights would not have an adequate remedy at law for any breach of this
     Rights Agreement and will be entitled to specific performance of the
     obligations under, and injunctive relief against actual or threatened
     violations of, the obligations of any Person subject to this Rights
     Agreement.

               Section 16.  Agreement of Right Holders.  Each holder of a
                            --------------------------
     Right, by accepting the same, consents and agrees with the Company and
     the Rights Agent and with every other holder of a Right that:

               (a)  prior to the Distribution Date, the Rights shall be
          evidenced by the certificates for Common Stock registered in the
          name of the holders of Common Stock (together, as applicable,
          with the Summary of Rights), which certificates for Common Stock
          shall also constitute certificates for





























     
<PAGE>

<PAGE>
     

          Rights, and not by separate Right Certificates, and each Right
          shall be transferable only simultaneously and together with the
          transfer of shares of Common Stock;

               (b)  after the Distribution Date, the Right Certificates are
          transferable only on the registry books of the Rights Agent if
          surrendered at the office of the Rights Agent designated for such
          purpose, duly endorsed or accompanied by a proper instrument of
          transfer; and

               (c)  the Company and the Rights Agent may deem and treat the
          person in whose name the Right Certificate (or, prior to the
          Distribution Date, the associated Common Stock certificate) is
          registered as the absolute owner thereof and of the Rights
          evidenced thereby (notwithstanding any notations of ownership or
          writing on the Right Certificates or the associated Common Stock
          certificate made by anyone other than the Company or the Rights
          Agent) for all purposes whatsoever, and neither the Company nor
          the Rights Agent shall be affected by any notice to the contrary.

               Section 17.  Right Certificate Holder Not Deemed a
                            -------------------------------------
     Stockholder.  No holder, as such, of any Right Certificate shall be
     -----------
     entitled to vote, receive dividends or be deemed for any purpose the
     holder of Preferred Stock or any other securities which may at any
     time be issuable on the exercise of the Rights represented thereby,
     nor shall anything contained herein or in any

















<PAGE>

<PAGE>
     

     Right Certificate be construed to confer upon the holder of any Right
     Certificate, as such, any of the rights of a stockholder of the
     Company or any right to vote for the election of directors or upon any
     matter submitted to stockholders at any meeting thereof (except as
     provided in Section 7(f) hereof), or to give or withhold consent to
     any corporate action (except as provided in Section 7(f) hereof), or
     to receive notice of meetings or other actions affecting stockholders
     (except as provided in Section 24 hereof), or to receive dividends or
     subscription rights, or otherwise, until the Right or Rights evidenced
     by such Right Certificate shall have been exercised in accordance with
     the provisions hereof.

               Section 18.  Concerning the Rights Agent.
                            ---------------------------

               (a)  The Company agrees to pay to the Rights Agent
     reasonable compensation for all services rendered by it hereunder and,
     from time to time, on demand of the Rights Agent, its reasonable
     expenses and counsel fees and other disbursements incurred in the
     administration and execution of this Rights Agreement and the exercise
     and performance of its duties hereunder.  The Company also agrees to
     indemnify the Rights Agent for, and to hold it harmless against, any
     loss, liability, or expense, incurred without negligence, bad faith or
     willful misconduct on the part of the Rights Agent, for anything done
     or omitted to be done by the Rights Agent in connection with the












































     
<PAGE>

<PAGE>
     

     acceptance and administration of this Rights Agreement, including the
     cost and expenses of defending against any claim of liability relating
     to the Rights or this Rights Agreement.

               (b)  The Rights Agent shall be protected against, and shall
     incur no liability for or in respect of, any action taken, suffered or
     omitted by it in connection with its administration of this Rights
     Agreement in reliance upon any Right Certificate or certificate for
     Preferred Stock or for other securities of the Company, instrument of
     assignment or transfer, power of attorney, endorsement, affidavit,
     letter, notice, direction, consent, certificate, statement or other
     paper or document believed by it to be genuine and to be signed,
     executed and, where necessary, verified or acknowledged, by the proper
     person or persons.

               Section 19.  Merger or Consolidation of, or Change in Name
                            ---------------------------------------------
     of, the Rights Agent.
     --------------------

               (a)  Any corporation into which the Rights Agent or any
     successor Rights Agent may be merged or with which it may be con-
     solidated, or any corporation resulting from any merger or consoli-
     dation to which the Rights Agent or any successor Rights Agent shall
     be a party, or any corporation succeeding to the corporate trust or
     stock transfer business of the Rights Agent or any successor Rights
     Agent, shall be the successor to the Rights Agent under this Rights
     Agreement without the execution or filing of any paper or any further
     act on the part of any of the parties
























     
<PAGE>

<PAGE>
     

     hereto, provided that such corporation would be eligible for
             --------
     appointment as a successor Rights Agent under the provisions of
     Section 21 hereof.  In case at the time such successor Rights Agent
     shall succeed to the agency created by this Rights Agreement any of
     the Rights Certificates shall have been countersigned but not
     delivered, any such successor Rights Agent may adopt the
     countersignature of the predecessor Rights Agent and deliver such
     Right Certificates so countersigned; and in case at that time any of
     the Right Certificates shall not have been countersigned, any
     successor Rights Agent may countersign such Right Certificates either
     in the name of the predecessor Rights Agent or in the name of the
     successor Rights Agent; and in all such cases such Right Certificates
     shall have the full force provided in the Right Certificates and in
     this Rights Agreement.

               (b)  In case at any time the name of the Rights Agent shall
     be changed and at such time any of the Right Certificates shall have
     been countersigned but not delivered, the Rights Agent may adopt the
     countersignature under its prior name and deliver Right Certificates
     so countersigned; in case at that time any of the Right Certificates
     shall not have been countersigned, the Rights Agent may countersign
     such Right Certificates either in its prior name or in its changed
     name; in all such cases such Right Certificates shall have the full
     force provided in the Right Certificates and in this Rights Agreement.





































     
<PAGE>

<PAGE>
     

               Section 20.  Duties of Rights Agent.  The Rights Agent
                            ----------------------
     undertakes the duties and obligations imposed by this Rights Agreement
     upon the following terms and conditions, by all of which the Company
     and the holders of Right Certificates by their acceptance thereof
     shall be bound:

               (a)  The Rights Agent may consult with legal counsel (who
     may be legal counsel for the Company), and the opinion of such counsel
     shall be full and complete authorization and protection to the Rights
     Agent as to any action taken or omitted by it in good faith and in
     accordance with such opinion.

               (b)  Whenever in the performance of its duties under this
     Rights Agreement the Rights Agent shall deem it necessary or desirable
     that any fact or matter be proved or established by the Company prior
     to taking or suffering any action hereunder, such fact or matter
     (unless other evidence in respect thereof be herein specifically
     prescribed) may be deemed to be conclusively proved and established by
     a certificate signed by the Chairman of the Board, the President or
     any Vice President and by the Treasurer or the Secretary of the
     Company and delivered to the Rights Agent.  Any such certificate shall
     be full authorization to the Rights Agent for any action taken or
     suffered in good faith by it under the provisions of this Rights
     Agreement in reliance upon such certificate.

























     
<PAGE>

<PAGE>
     

               (c)  The Rights Agent shall be liable hereunder only for its
     own negligence, bad faith or willful misconduct.

               (d)  The Rights Agent shall not be liable for or by reason
     of any of the statements of fact or recitals contained in this Rights
     Agreement or in the Right Certificates (except its countersignature
     thereof) or be required to verify the same, but all such statements
     and recitals are and shall be deemed to have been made by the Company
     only.

               (e)  The Rights Agent shall not be under any responsibility
     in respect of the validity of this Rights Agreement or the execution
     and delivery hereof (except the due execution hereof by the Rights
     Agent) or in respect of the validity or execution of any Right
     Certificate (except its countersignature thereof); nor shall it be
     responsible for any breach by the Company of any covenant or condition
     contained in this Rights Agreement or in any Right Certificate; nor
     shall it be responsible for any adjustment required under the
     provisions of Section 11 or 13 hereof or responsible for the manner,
     method or amount of any such adjustment or the ascertaining of the
     existence of facts that would require any such adjustment (except with
     respect to the exercise of Rights evidenced by Right Certificates
     after receipt of a certificate describing any such adjustment); nor
     shall it by any act hereunder be deemed to make any representation or
     warranty as to the authorization or reservation of any




























     
<PAGE>

<PAGE>
     

     shares of Preferred Stock to be issued pursuant to this Rights
     Agreement or any Right Certificate or as to whether any shares of
     Preferred Stock will, when issued, be validly authorized and issued,
     fully paid and nonassessable.

               (f)  The Company agrees that it will perform, execute,
     acknowledge and deliver or cause to be performed, executed,
     acknowledged and delivered all such further and other acts,
     instruments and assurances as may reasonably be required by the Rights
     Agent for the carrying out or performing by the Rights Agent of the
     provisions of the Rights Agreement.

               (g)  The Rights Agent is hereby authorized and directed to
     accept instructions with respect to the performance of its duties
     hereunder from the Chairman of the Board, the President or any Vice
     President or the Secretary or the Treasurer of the Company, and to
     apply to such officers for advice or instructions in connection with
     its duties, and it shall not be liable for any action taken or
     suffered to be taken by it in good faith in accordance with
     instructions of any such officer.

               (h)  The Rights Agent and any shareholder, director, officer
     or employee of the Rights Agent may buy, sell or deal in any of the
     Rights or other securities of the Company or become pecuniarily
     interested in any transaction in which the Company may be interested,
     or contract with or lend money to the Company or otherwise act as
     fully and freely as though it were not the































     
<PAGE>

<PAGE>
     

     Rights Agent under this Rights Agreement.  Nothing herein shall
     preclude the Rights Agent from acting in any other capacity for the
     Company or for any other legal entity.

               (i)  The Rights Agent may execute and exercise any of the
     rights or powers hereby vested in it or perform any duty hereunder
     either itself or by or through its attorneys or agents, and the Rights
     Agent shall not be answerable or accountable for any act, default,
     neglect or misconduct of any such attorneys or agents or for any loss
     to the Company resulting from any such act, default, neglect or
     misconduct, provided reasonable care was exercised in the selection
     and continued employment thereof.

               Section 21.  Change of Rights Agent.  The Rights Agent or
                            ----------------------
     any successor Rights Agent may resign and be discharged from its
     duties under this Rights Agreement upon 30 days' notice in writing
     mailed to the Company and to each transfer agent of the Common Stock
     and the Preferred Stock by registered or certified mail.  The Company
     may remove the Rights Agent or any successor Rights Agent (with or
     without cause) upon 30 days' notice in writing, mailed to the Rights
     Agent or successor Rights Agent, as the case may be, and to each
     transfer agent of the Common Stock and the Preferred Stock by
     registered or certified mail.  If the Rights Agent shall resign or be
     removed or shall otherwise become incapable of acting, the Company
     shall appoint a successor to the Rights Agent.  Notwithstanding the
     foregoing provisions of this





























     
<PAGE>

<PAGE>
     

     Section 21, in no event shall the resignation or removal of a Rights
     Agent be effective until a successor Rights Agent shall have been
     appointed and have accepted such appointment.  If the Company shall
     fail to make such appointment within a period of 30 days after such
     removal or after it has been notified in writing of such resignation
     or incapacity by the resigning or incapacitated Rights Agent or by the
     holder of a Right Certificate (who shall, with such notice, submit his
     Right Certificate for inspection by the Company), then the incumbent
     Rights Agent or the holder of record of any Right Certificate may
     apply to any court of competent jurisdiction for the appointment of a
     new Rights Agent.  Any successor Rights Agent, whether appointed by
     the Company or by such a court, shall be (a) a corporation organized
     and doing business under the laws of the United States or of any state
     thereof, in good standing, which is authorized under such laws to
     exercise corporate trust or stock transfer powers and is subject to
     supervision or examination in the conduct of its corporate trust or
     stock transfer business by federal or state authorities and which has
     at the time of its appointment as Rights Agent a combined capital and
     surplus of at least $5,000,000 or (b) an Affiliate controlled by a
     corporation described in clause (a) of this sentence.  After
     appointment, the successor Rights Agent shall be vested with the same
     powers, rights, duties and responsibilities as if it had been
     originally















































     
<PAGE>

<PAGE>
     

     named as Rights Agent without further act or deed, but the predecessor
     Rights Agent shall deliver and transfer to the successor Rights Agent
     any property at the time held by it hereunder, and execute and deliver
     any further assurance, conveyance, act or deed necessary for the
     purpose.  Not later than the effective date of any such appointment,
     the Company shall file notice thereof in writing with the predecessor
     Rights Agent and each transfer agent of the Common Stock and Preferred
     Stock, and mail a notice thereof in writing to the registered holders
     of the Right Certificates.  Failure to give any notice provided for in
     this Section 21, however, or any defect therein, shall not affect the
     legality or validity of the resignation or removal of the Rights Agent
     or the appointment of the successor Rights Agent, as the case may be. 
     Notwithstanding the foregoing provisions, in the event of resignation,
     removal or incapacity of the Rights Agent, the Company shall have the
     authority to act as the Rights Agent until a successor Rights Agent
     shall have assumed the duties of the Rights Agent hereunder.

               Section 22.  Issuance of New Right Certificates. 
                            ----------------------------------
     Notwithstanding any of the provisions of this Rights Agreement or of
     the Rights to the contrary, the Company may, at its option, issue new
     Right Certificates evidencing Rights in such form as may be approved
     by its Board of Directors to reflect any adjustment or change in the
     Exercise Price per share and the number or

































     
<PAGE>

<PAGE>
     

     kind or class of shares of stock or other securities or property
     purchasable under the Right Certificates made in accordance with the
     provisions of this Rights Agreement.

               Section 23.  Redemption.
                            ----------

               (a)  The Company may, at its option, but only by the vote of
     a majority of the Board of Directors, redeem all but not less than all
     of the then outstanding Rights, at any time prior to the Close of
     Business on the earlier of (i) the tenth day following the Stock
     Acquisition Date (subject to extension by the Company as provided in
     Section 26 hereof) or (ii) the Final Expiration Date, at a redemption
     price of $.001 per Right, subject to adjustments as provided in
     subsection (c) below (the "Redemption Price"); provided, however, that
                                                    --------  -------
     from and after the time that any Person shall become an Acquiring
     Person (other than pursuant to a Qualifying Tender Offer), the Company
     may redeem the Rights only if at the time of the action of the Board
     of Directors there are then in office not less than two Continuing
     Directors and such redemption is approved by a majority of the
     Continuing Directors then in office.  Notwithstanding anything
     contained in this Agreement to the contrary, the Rights shall not be
     exercisable pursuant to Section 11(a)(ii) prior to the expiration of
     the Company's right of redemption hereunder.

               (b)  Without any further action and without any notice, the
     right to exercise the Rights will terminate effective at the



























     
<PAGE>

<PAGE>
     

     time of the action of the Board of Directors ordering the redemption
     of the Rights and the only right thereafter of the holders of Rights
     shall be to receive the Redemption Price.  Within 10 days after the
     effective time of the action of the Board of Directors ordering the
     redemption of the Rights, the Company shall give notice of such
     redemption to the holders of the then outstanding Rights by mailing
     such notice to all such holders at their last addresses as they appear
     upon the registry books of the Rights Agent or, prior to the
     Distribution Date, on the registry books of the transfer agent for the
     Common Stock.  Any notice which is mailed in the manner herein
     provided shall be deemed given, whether or not the holder receives the
     notice.  Each notice of redemption will state the method by which the
     payment of the Redemption Price will be made.  At the option of the
     Board of Directors, the Redemption Price may be paid in cash to each
     Rights holder or by the issuance of shares (and, at the Company's
     election pursuant to Section 14(b) hereof, cash or depositary receipts
     in lieu of fractions of shares other than fractions which are integral
     multiples of one one-hundredth (1/100) of a share) of Preferred Stock
     having a Fair Market Value equal to such cash payment.

               (c)  In the event the Company shall at any time after the
     date of this Rights Agreement (A) pay any dividend on Common Stock in
     shares of Common Stock, (B) subdivide or split the out






























     
<PAGE>

<PAGE>
     

     standing shares of Common Stock into a greater number of shares or (C)
     combine or consolidate the outstanding shares of Common Stock into a
     smaller number of shares or effect a reverse split of the outstanding
     shares of Common Stock, then, and in each such event, the Redemption
     Price shall be adjusted so that the Redemption Price after such event
     shall equal the Redemption Price immediately prior to such event
     multiplied by a fraction the numerator of which is the number of
     shares of Common Stock outstanding immediately after such event and
     the denominator of which is the number of shares of Common Stock
     outstanding immediately prior to such event; provided, however, that
                                                  --------  -------
     in each case such adjustment to the Redemption Price shall be made
     only if the amount of the Redemption Price shall be reduced or
     increased by $.001 per Right.

               Section 24.  Notice of Proposed Actions.
                            --------------------------

               (a)  In case the Company, after the Distribution Date, shall
     propose (i) to effect any of the transactions referred to in Section
     11(a)(i) or 11(g) or (ii) to offer to the holders of record of its
     Common Stock options, warrants, or other rights to subscribe for or to
     purchase shares of Common Stock (including any security convertible
     into or exchangeable for Common Stock) or shares of stock of any class
     or any other securities, options, warrants, convertible or
     exchangeable securities or other rights, or (iii) to effect any
     reclassification of its Preferred Stock or























     
<PAGE>

<PAGE>
     

     Common Stock or any recapitalization or reorganization of the Company,
     or (iv) to effect any consolidation or merger with or into, or to
     effect any sale or other transfer (or to permit one or more of its
     Subsidiaries to effect any sale or other transfer), in one or more
     transactions, of more than 50% of the assets or earning power of the
     Company and its Subsidiaries (taken as a whole) to, any other Person
     or Persons, or (v) to effect the liquidation, dissolution or winding
     up of the Company, then, in each such case, the Company shall give to
     each holder of record of a Right Certificate, in accordance with
     Section 25, notice of such proposed action, which shall specify the
     record date for the purposes of such transaction referred to in
     Section 11(a)(i) or such dividend or distribution, or the date on
     which such reclassification, recapitalization, reorganization,
     consolidation, merger, sale or transfer of assets, liquidation,
     dissolution, or winding up is to take place and the record date for
     determining participation therein by the holders of record of Common
     Stock or Preferred Stock, if any such date is to be fixed, and such
     notice shall be so given in the case of any action covered by clause
     (i) or (ii) above at least 10 days prior to the record date for deter-
     mining holders of record of the Preferred Stock for purposes of such
     action, and in the case of any such other action, at least 10 days
     prior to the date of the taking of such proposed action or the date of
     participation therein by the holders of


















     
<PAGE>

<PAGE>
     

     record of Common Stock or Preferred Stock, whichever shall be the
     earlier.  The failure to give notice required by this Section 24 or
     any defect therein shall not affect the legality or validity of the
     action taken by the Company or the vote upon any such action.

               (b)  In case any of the transactions referred to in Section
     11(a)(i), 11(g) or 13 of this Rights Agreement are proposed, then, in
     any such case, the Company shall give to each holder of Rights, in
     accordance with Section 25 hereof, notice of the proposal of such
     transaction at least 10 days prior to consummating such transaction,
     which notice shall specify the proposed event and the consequences of
     the event to holders of Rights under Section 11(a)(i), 11(g) or 13
     hereof, as the case may be, and, upon consummating such transaction,
     shall similarly give notice thereof to each holder of Rights.

               Section 25.  Notices.  Notices or demands authorized by this
                            -------
     Rights Agreement to be given or made by the Rights Agent or by the
     holder of record of any Right Certificate or Right to or on the
     Company shall be sufficiently given or made if sent by first-class
     mail, postage prepaid, addressed (until another address is filed in
     writing with the Rights Agent) as follows:

                    U.S. Bioscience, Inc.
                    One Tower Bridge
                    100 Front Street
                    West Conshohocken, Pennsylvania  19428
                    Attention:  Corporate Secretary





















     
<PAGE>

<PAGE>
     

     Subject to the provisions of Section 21, any notice or demand
     authorized by this Rights Agreement to be given or made by the Company
     or by the holder of record of any Right Certificate or Right to or on
     the Rights Agent shall be sufficiently given or made if sent by first-
     class mail, postage prepaid, addressed (until another address is filed
     in writing with the Company) as follows:

               Chemical Mellon Shareholder Services L.L.C.
               450 West 33rd Street
               15th Floor
               New York, New York 10001
               Attention:  Connie Cotter

     Notices or demands authorized by this Rights Agreement to be given or
     made by the Company or the Rights Agent to the holder of record of any
     Right Certificate or Right shall be sufficiently given or made if sent
     by first-class mail, postage prepaid, addressed to such holder at the
     address of such holder as shown on the registry books of the Company.

               Section 26.  Supplements and Amendments.  For as long as the
                            --------------------------
     Rights are then redeemable and except as provided in the last sentence
     of this Section 26, the Company may in its sole and absolute
     discretion, and the Rights Agent shall if the Company so directs,
     supplement or amend any provision of this Agreement without the
     approval of any holders of the Rights.  At any time when the Rights
     are not then redeemable and except as provided in the last sentence of
     this Section 26, the Company may, and the





















     
<PAGE>

<PAGE>
     

     Rights Agent shall if the Company so directs, supplement or amend this
     Rights Agreement without the approval of any holders of Right
     Certificates (i) to cure any ambiguity, (ii) to correct or supplement
     any provision contained herein which may be defective or inconsistent
     with any other provisions herein or (iii) to change or supplement the
     provisions hereunder in any manner which the Company may deem
     necessary or desirable, provided that no such supplement or amendment
     pursuant to this clause (iii) shall materially adversely affect the
     interest of the holders of Right Certificates.  Upon the delivery of a
     certificate from an appropriate officer of the Company which states
     that the proposed supplement or amendment is in compliance with the
     terms of this Section 26, the Rights Agent shall execute such
     supplement or amendment.  This Agreement may be amended or
     supplemented at any time with the approval of a majority of the
     registered holders of the Right Certificates (and, prior to the
     Distribution Date, the Common Stock).  Notwithstanding anything
     contained in this Rights Agreement to the contrary, no supplement or
     amendment shall be made which changes the Redemption Price or the
     Final Expiration Date and supplements or amendments may be made after
     the time that any Person becomes an Acquiring Person (other than
     pursuant to a Qualifying Tender Offer) only if at the time of the
     action of the Board of Directors approving such supplement or
     amendment there are then in office not less than two Continuing
     Directors







































     
<PAGE>

<PAGE>
     

     and such supplement or amendment is approved by a majority of the
     Continuing Directors then in office.

               Section 27.  Successors.  All of the covenants and
                            ----------
     provisions of this Rights Agreement by or for the benefit of the
     Company or the Rights Agent shall bind and inure to the benefit of
     their respective successors and assigns hereunder.

               Section 28.  Benefits of this Rights Agreement.  Nothing in
                            ---------------------------------
     this Rights Agreement shall be construed to give to any person or
     corporation other than the Company, the Rights Agent and the
     registered holders of the Right Certificates (and, prior to the
     Distribution Date, the holders of Common Stock in their capacity as
     holders of the Rights) any legal or equitable right, remedy or claim
     under this Rights Agreement; but this Rights Agreement shall be for
     the sole and exclusive benefit of the Company, the Rights Agent and
     the holders of record of the Right Certificates (and, prior to the
     Distribution Date, the holders of Common Stock in their capacity as
     holders of the Rights).

               Section 29.  Delaware Contract.  This Rights Agreement and
                            -----------------
     each Right Certificate issued hereunder shall be deemed to be a
     contract made under the laws of the State of Delaware and for all
     purposes shall be governed by and construed and enforced in accordance
     with the laws of such state applicable to contracts to be made and
     performed entirely within such state.





















     
<PAGE>

<PAGE>
     

               Section 30.  Counterparts.  This Rights Agreement may be
                            ------------
     executed in any number of counterparts and each of such counterparts
     shall for all purposes be deemed to be an original, and all such
     counterparts shall together constitute but one and the same
     instrument.

               Section 31.  Descriptive Headings.  Descriptive headings of
                            --------------------
     the several Sections of this Rights Agreement are inserted for
     convenience only and shall not control or affect the meaning or
     construction of any of the provisions hereof.

               Section 32.  Severability.  If any term, provision, covenant
                            ------------
     or restriction of this Rights Agreement is held by a court of
     competent jurisdiction or other authority to be invalid, void or
     unenforceable, the remainder of the terms, provisions, covenants and
     restrictions of this Rights Agreement shall remain in full force and
     effect and shall in no way be affected, impaired or invalidated.



































     
<PAGE>

<PAGE>
     


               IN WITNESS WHEREOF, the parties hereto have caused this
     Rights Agreement to be duly executed, all as of the day and year first
     above written.

                                        U.S. BIOSCIENCE, INC.


     Attest:/s/ Martha E. Manning       By /s/ Robert I. Kriebel           
            -----------------------       ---------------------------------
               (SEAL)                      Robert I. Kriebel  
                                           Senior Vice President -
                                           Finance and Administration
                                           and Treasurer


                                        RIGHTS AGENT


     Attest:/s/ John F. Keegan          By /s/ George O. Renz              
            -----------------------       ---------------------------------
               (SEAL)                      George O. Renz
                                           Assistant Vice President
<PAGE>


<PAGE>
                                                              EXHIBIT A   


                 UNDER CERTAIN CIRCUMSTANCES AS PROVIDED IN THE
                 RIGHTS AGREEMENT (AS REFERRED TO BELOW), RIGHTS
                  ISSUED TO OR BENEFICIALLY OWNED BY ACQUIRING
               PERSONS OR THEIR AFFILIATES OR ASSOCIATES (AS SUCH
                TERMS ARE DEFINED IN THE RIGHTS AGREEMENT) OR ANY
               SUBSEQUENT HOLDER OF SUCH RIGHTS SHALL BE NULL AND
                 VOID AND MAY NOT BE TRANSFERRED TO ANY PERSON.

                              U.S. BIOSCIENCE, INC.

                          SUMMARY OF RIGHTS TO PURCHASE
                         SERIES A JUNIOR PREFERRED STOCK


               On May 19, 1995, the Board of Directors of U.S. Bioscience,
     Inc. (the "Company") declared a dividend distribution of one Preferred
     Stock Purchase Right for each outstanding share of Common Stock, par
     value $.005 per share (the "Common Stock"), of the Company.  The
     distribution is payable as of May 29, 1995 to stockholders of record
     on that date.  Each Right entitles the registered holder to purchase
     from the Company one one-hundredth (1/100) of a share of preferred
     stock of the Company, designated as Series A Junior Preferred Stock
     (the "Preferred Stock") at a price of $15 per one one-hundredth
     (1/100) of a share ("Exercise Price").  The description and terms of
     the Rights are set forth in a Rights Agreement, dated as of May 19,
     1995, as hereafter amended from time to time (the "Rights Agreement"),
     between the Company and Chemical Mellon Shareholder Services L.L.C.,
     as Rights Agent (the "Rights Agent").

               As discussed below, initially the Rights will not be
               ----------------------------------------------------
     exercisable, certificates will not be sent to stockholders and the
     ------------------------------------------------------------------
     Rights will automatically trade with the Common Stock.
     ------------------------------------------------------

               The Rights, unless earlier redeemed by the Board of
     Directors, become exercisable upon the close of business on the day
     (the "Distribution Date") which is the earlier of (i) the tenth day
     following a public announcement that a person or group of affiliated
     or associated persons, with certain exceptions set forth below, has
     acquired beneficial ownership of 15% or more of the outstanding voting
     stock of the Company (an "Acquiring Person") and (ii) the tenth
     business day (or such later date as may be determined by the Board of
     Directors prior to such time as any person or group of affiliated or
     associated persons becomes an Acquiring Person) after the date of the
     commencement or announcement of a person's or group's intention to
     commence a tender or exchange offer the consummation of which would
     result in the ownership of 30% or more of the Company's outstanding
     voting stock (even if no shares are actually purchased pursuant to
     such offer); prior thereto, the Rights would not be














     NYFS02...:\09\78509\0002\1196\EXH4055C.34B
<PAGE>

<PAGE>
     

     exercisable, would not be represented by a separate certificate, and
     would not be transferable apart from the Company's Common Stock, but
     will instead be evidenced, with respect to any of the Common Stock
     certificates outstanding as of May 29, 1995, by such Common Stock
     certificate with a copy of this Summary of Rights attached thereto. 
     An Acquiring Person does not include (A) the Company, (B) any
     subsidiary of the Company, (C) any employee benefit plan or employee
     stock plan of the Company or of any subsidiary of the Company, or any
     trust or other entity organized, appointed, established or holding
     Common Stock for or pursuant to the terms of any such plan or (D) any
     person or group whose ownership of 15% or more of the shares of voting
     stock of the Company then outstanding results solely from (i) any
     action or transaction or transactions approved by the Board of
     Directors before such person or group became an Acquiring Person or
     (ii) a reduction in the number of issued and outstanding shares of
     voting stock of the Company pursuant to a transaction or transactions
     approved by the Board of Directors (provided that any person or group
     that does not become an Acquiring Person by reason of clause (i) or
     (ii) above shall become an Acquiring Person upon acquisition of an
     additional 1% of the Company's voting stock unless such acquisition of
     additional voting stock will not result in such person or group
     becoming an Acquiring Person by reason of such clause (i) or (ii)).

               Until the Distribution Date (or earlier redemption or
     expiration of the Rights), new Common Stock certificates issued after
     May 29, 1995 will contain a legend incorporating the Rights Agreement
     by reference.  Until the Distribution Date (or earlier redemption or
     expiration of the Rights), the surrender for transfer of any of the
     Common Stock certificates outstanding as of May 29, 1995, with or
     without a copy of this Summary of Rights attached thereto, will also
     constitute the transfer of the Rights associated with the Common Stock
     represented by such certificate.  As soon as practicable following the
     Distribution Date, separate certificates evidencing the Rights ("Right
     Certificates") will be mailed to holders of record of the Common Stock
     as of the close of business on the Distribution Date and such separate
     certificates alone will evidence the Rights from and after the
     Distribution Date.

               The Rights are not exercisable until the Distribution Date. 
     The Rights will expire at the close of business on May 19, 2005,
     unless earlier redeemed by the Company as described below.

               The Preferred Stock is nonredeemable and, unless otherwise
     provided in connection with the creation of a subsequent series of
     preferred stock, subordinate to any other


















     
<PAGE>

<PAGE>
     

     series of the Company's preferred stock.  The Preferred Stock may not
     be issued except upon exercise of Rights.  Each share of Preferred
     Stock will be entitled to receive when, as and if declared, a
     quarterly dividend in an amount equal to the greater of $1.00 per
     share or 100 times the cash dividends declared on the Company's Common
     Stock.  In addition, the Preferred Stock is entitled to 100 times any
     non-cash dividends (other than dividends payable in equity securities)
     declared on the Common Stock, in like kind.  In the event of the
     liquidation of the Company, the holders of Preferred Stock will be
     entitled to receive, for each share of Preferred Stock, a payment in
     an amount equal to the greater of $1,500 or 100 times the payment made
     per share of Common Stock.  Each share of Preferred Stock will have
     100 votes, voting together with the Common Stock.  In the event of any
     merger, consolidation or other transaction in which Common Stock is
     exchanged, each share of Preferred Stock will be entitled to receive
     100 times the amount received per share of Common Stock.  The rights
     of Preferred Stock as to dividends, liquidation and voting are
     protected by anti-dilution provisions.

               The number of shares of Preferred Stock issuable upon
     exercise of the Rights is subject to certain adjustments from time to
     time in the event of a stock dividend on, or a subdivision or
     combination of, the Common Stock.  The Exercise Price for the Rights
     is subject to adjustment in the event of extraordinary distributions
     of cash or other property to holders of Common Stock.

               Unless the Rights are earlier redeemed or the transaction is
     approved by the Board of Directors and the Continuing Directors, if
     the Company at any time after the Distribution Date were to be
     acquired in a merger or other business combination (in which any
     shares of Common Stock are changed into or exchanged for other
     securities or assets) or more than 50% of the assets or earning power
     of the Company and its subsidiaries (taken as a whole) were to be sold
     or transferred in one or a series of related transactions, the Rights
     Agreement provides that proper provision will be made so that each
     holder of record of a Right will from and after such date have the
     right to receive, upon payment of the Exercise Price, that number of
     shares of common stock of the acquiring company having a market value
     at the time of such transaction equal to two times the Exercise Price. 
     In addition, unless the Rights are earlier redeemed, in the event that
     a person or group becomes the beneficial owner of 15% or more of the
     Company's voting stock (other than pursuant to a tender or exchange
     offer (a "Qualifying Tender Offer") for all outstanding shares of
     Common Stock that is






























     
<PAGE>

<PAGE>
     

     approved by the Board of Directors, after taking into account the
     long-term value of the Company and all other factors they consider
     relevant in the circumstances), the Rights Agreement provides that
     proper provisions will be made so that each holder of record of a
     Right, other than the Acquiring Person (whose Rights will thereupon
     become null and void), will thereafter have the right to receive, upon
     payment of the Exercise Price, that number of shares of the Preferred
     Stock having a market value at the time of the transaction equal to
     two times the Exercise Price (such market value to be determined with
     reference to the market value of the Company's Common Stock as
     provided in the Rights Agreement).

               Fractions of shares of Preferred Stock (other than fractions
     which are integral multiples of one one-hundredth of a share) may, at
     the election of the Company, be evidenced by depositary receipts.  The
     Company may also issue cash in lieu of fractional shares which are not
     integral multiples of one one-hundredth of a share.

               At any time on or prior to the close of business on the
     earlier of (i) the tenth day after the time that a person has become
     an Acquiring Person (or such later date as a majority of the Board of
     Directors and a majority of the Continuing Directors (as defined in
     the Rights Agreement) may determine) or (ii) May 19, 2005, the Company
     may redeem the Rights in whole, but not in part, at a price of $.001
     per Right (the "Redemption Price").  The Rights may be redeemed after
     the time that any Person has become an Acquiring Person only if
     approved by a majority of the Continuing Directors.  Immediately upon
     the effective time of the action of the Board of Directors of the
     Company authorizing redemption of the Rights, the right to exercise
     the Rights will terminate and the only right of the holders of Rights
     will be to receive the Redemption Price.

               For as long as the Rights are then redeemable, the Company
     may, except with respect to the redemption price or date of expiration
     of the Rights, amend the Rights in any manner, including an amendment
     to extend the time period in which the Rights may be redeemed.  At any
     time when the Rights are not then redeemable, the Company may amend
     the Rights in any manner that does not materially adversely affect the
     interests of holders of the Rights as such.  Amendments to the Rights
     Agreement from and after the time that any Person becomes an Acquiring
     Person requires the approval of a majority of the Continuing Directors
     (as provided in the Rights Agreement).































     
<PAGE>

<PAGE>
     

               Until a Right is exercised, the holder, as such, will have
     no rights as a stockholder of the Company, including, without
     limitation, the right to vote or to receive dividends.

               A copy of the Rights Agreement has been filed with the
     Securities and Exchange Commission as an Exhibit to a Current Report
     on Form 8-K dated June 7, 1995.  A copy of the Rights Agreement is
     available free of charge from the Company.  This summary description
     of the Rights does not purport to be complete and is qualified in its
     entirety by reference to the Rights Agreement which is incorporated in
     this summary description herein by reference.































































     
<PAGE>


<PAGE>
                                                                  EXHIBIT B
                                              


                           [Form of Right Certificate]


     Certificate No. W-                                              Rights
                                                               ------

          NOT EXERCISABLE AFTER May 19, 2005 OR EARLIER IF REDEEMED. 
          THE RIGHTS ARE SUBJECT TO REDEMPTION, AT THE OPTION OF THE
          COMPANY AND UNDER CERTAIN OTHER CIRCUMSTANCES, AT $.001 PER
          RIGHT (SUBJECT TO ADJUSTMENT), ON THE TERMS SET FORTH OR
          REFERRED TO IN THE RIGHTS AGREEMENT.  UNDER CERTAIN
                                                -------------
          CIRCUMSTANCES AS PROVIDED IN THE RIGHTS AGREEMENT (AS REFERRED TO
          -----------------------------------------------------------------
          BELOW), RIGHTS ISSUED TO OR BENEFICIALLY OWNED BY ACQUIRING
          -----------------------------------------------------------
          PERSONS OR THEIR AFFILIATES OR ASSOCIATES (AS SUCH TERMS ARE
          ------------------------------------------------------------
          DEFINED IN THE RIGHTS AGREEMENT) OR ANY SUBSEQUENT HOLDER OF SUCH
          -----------------------------------------------------------------
          RIGHTS SHALL BE NULL AND VOID AND MAY NOT BE TRANSFERRED TO ANY
          ---------------------------------------------------------------
          PERSON.
          ------


                                Right Certificate
                              U.S. BIOSCIENCE, INC.

                This certifies that                   , or registered
     assigns, is the registered owner of the number of Rights set forth
     above, each of which entitles the owner thereof, subject to the terms,
     provisions and conditions of the Rights Agreement dated as of May 19,
     1995, as hereafter amended from time to time (the "Rights Agreement")
     between U.S. Bioscience, Inc., a Delaware corporation (the "Company"),
     and Chemical Mellon Shareholder Services L.L.C., a New Jersey Limited
     Liability Company (the "Rights Agent"), to purchase from the Company
     at any time after the Distribution Date (as such term is defined in
     the Rights Agreement) and prior to 5:00 P.M. (Pennsylvania time) on
     May 19, 2005 at the office of the Rights Agent designated in the
     Rights Agreement for such purpose, or its successor as Rights



















     NYFS02...:\09\78509\0002\1196\EXH4055C.43A
<PAGE>

<PAGE>
     

     Agent, in New York, New York, one one-hundredth (1/100) of a fully
     paid nonassessable share of Series A Junior Preferred Stock (the
     "Preferred Stock") of the Company at a purchase price of $15, as the
     same may from time to time be adjusted in accordance with the Rights
     Agreement (the "Exercise Price"), upon presentation and surrender of
     this Right Certificate with the Form of Election to Purchase attached
     hereto duly executed.

               As provided in the Rights Agreement, the Exercise Price and
     the number of shares of Preferred Stock which may be purchased upon
     the exercise of the Rights evidenced by this Right Certificate are
     subject to modification and adjustment upon the happening of certain
     events and, upon the happening of certain events, securities other
     than shares of Preferred Stock, or other property, may be acquired
     upon exercise of the Rights evidenced by this Right Certificate, as
     provided in the Rights Agreement.

               This Right Certificate is subject to all of the terms,
     provisions and conditions of the Rights Agreement, which terms,
     provisions and conditions are incorporated herein by reference and
     made a part hereof and to which Rights Agreement reference is hereby
     made for a full description of the rights, limitations of rights,
     obligations, duties and immunities of the Rights Agent, the Company
     and the holders of record of Right Certificates.  Copies of the Rights
     Agreement are on file at the principal executive office of the
     Company.












































     
<PAGE>

<PAGE>
     

               This Right Certificate, with or without other Right
     Certificates, upon surrender at the office of the Rights Agent
     designated in the Rights Agreement for such purpose, may be exchanged
     for another Right Certificate or Right Certificates of like tenor and
     date evidencing Rights entitling the holder of record to purchase a
     like aggregate number of shares of Preferred Stock as the Rights
     evidenced by the Right Certificate or Right Certificates surrendered
     shall have entitled such holder to purchase.  If this Right
     Certificate shall be exercised in part, the holder shall be entitled
     to receive upon surrender hereof, another Right Certificate or Right
     Certificates for the number of whole Rights not exercised.

               Subject to the provisions of the Rights Agreement, the
     Rights evidenced by this Certificate may be redeemed by the Company at
     its option or under certain other circumstances at a redemption price
     of $.01 per Right.

               No fractional shares of Preferred Stock (other than
     fractions which are integral multiples of one one-hundredth (1/100) of
     a share) are required to be issued upon the exercise of any Right or
     Rights evidenced hereby, and in lieu thereof the Company may cause
     depositary receipts to be issued and/or a cash payment may be made, as
     provided in the Rights Agreement.

               No holder of this Right Certificate, as such, shall be
     entitled to vote or receive dividends or be deemed for any



































     
<PAGE>

<PAGE>
     

     purpose the holder of Preferred Stock or of any other securities of
     the Company which may at any time be issuable on the exercise hereof,
     nor shall anything contained in the Rights Agreement or herein be
     construed to confer upon the holder hereof, as such, any of the rights
     of a stockholder of the Company or any right to vote for the election
     of directors or upon any matter submitted to stockholders at meeting
     thereof, or to give or withhold consent to any corporate action or to
     receive notice of meetings or other actions affecting stockholders
     (except as provided in the Rights Agreement), or to receive dividends
     or subscription rights, or otherwise, until the Right or Rights
     evidenced by this Right Certificate shall have been exercised as
     provided in the Rights Agreement.

               This Right Certificate shall not be valid or obligatory for
     any purpose until it shall have been countersigned by the Rights
     Agent.












































     
<PAGE>

<PAGE>
     

               WITNESS the facsimile signature of the proper officers of
     the Company and its corporate seal.  Dated as of              , 199 .
                                                     --------------     -

     ATTEST:                            U.S. BIOSCIENCE, INC.




                                        By                                 
     -------------------------            ---------------------------------
     Secretary                             Title:


     Countersigned:

     [Rights Agent]


     By                       
       -----------------------
       Authorized Signature





















































    <PAGE>

<PAGE>
     

                   [Form of Reverse Side of Right Certificate]

                               FORM OF ASSIGNMENT
                               ------------------

                (To be executed by the registered holder if such
               holder desires to transfer the Right Certificates.)

               FOR VALUE RECEIVED                                          
                                  -----------------------------------------
     hereby sells, assigns and transfers unto                              
                                              -----------------------------
                                                                           
     (Please print name and address of transferee)-------------------------
                                                                           
     ----------------------------------------------------------------------
     Rights evidenced by this Right Certificate, together with all right,
     title and interest therein, and does hereby irrevocably constitute and
     appoint 
            ---------------------------------------------------------------
     Attorney to transfer the within Right Certificate on the books of the
     within-named Company, with full power of substitution.

     Dated:                 , 199  
            ----------------     --
                                                                           
                                        -----------------------------------
                                             Signature
     Signature Guaranteed:






































     
<PAGE>

<PAGE>
     

                                   Certificate
                                   ------------

               The undersigned hereby certifies by checking the appropriate
     boxes that:

               (1)  this Right Certificate [  ] is [    ] is not being
     sold, assigned or transferred by or on behalf of a Person who is or
     was an Acquiring Person or an Associate or an Affiliate thereof (as
     such terms are defined in the Rights Agreement); and

               (2)  after due inquiry and to the best knowledge of the
     undersigned, it [        ] did [        ] did not acquire the Rights
     evidenced by this Right Certificate from any Person who is, was or
     subsequently became an Acquiring Person or an Affiliate or Associate
     thereof (as such terms are defined in the Rights Agreement).
     Dated:              , 199  
           --------------     -         ----------------------------------- 
                                             Signature

                                     NOTICE
                                     ------

               The signature to the foregoing Assignment and Certificate
     must correspond to the name as written upon the face of this Right
     Certificate in every particular, without alteration or enlargement or
     any change whatsoever.

























     
<PAGE>

<PAGE>
     

                          FORM OF ELECTION TO PURCHASE
                          -----------------------------

                      (To be executed if registered holder
                   desires to exercise the Right Certificate.)

     TO U.S. BIOSCIENCE, INC.:

               The undersigned hereby irrevocably elects to exercise
                       Rights represented by this Right Certificate to
     -----------------
     purchase the shares of Preferred Stock issuable upon the exercise of
     such Rights and requests that certificates for such share(s) be issued
     in the following name:

     Please insert social security
     or other identifying number:                                          
                                 ------------------------------------------

                                                                           
     ----------------------------------------------------------------------
                            (Please print name and address)    


     ----------------------------------------------------------------------


     If such number of Rights shall not be all the Rights evidenced by this
     Right Certificate, a new Right Certificate for the balance remaining
     of such Rights shall be registered in the name of and delivered to:























     
<PAGE>

<PAGE>
     

     Please insert social security
     or other identifying number:             
                                 ------------------------------------------
                                                                           
     ----------------------------------------------------------------------
                         (Please print name and address)
                                                                           
     ----------------------------------------------------------------------

     Dated:              , 199  
           --------------     --
                                                                           
                                   ----------------------------------------
                                   Signature
                                   (Signature must conform in all
                                   respects to name of holder as
                                   specified on the fact of this
                                   Right Certificate)

     Signature Guaranteed:











































<PAGE>


<PAGE>
                                                                  EXHIBIT C


                                     FORM OF
                           CERTIFICATE OF DESIGNATIONS
                                       OF
                         SERIES A JUNIOR PREFERRED STOCK
                                       OF
                              U.S. BIOSCIENCE, INC.

                     Pursuant to Section 151 of the Delaware
                             General Corporation Law


               I, Robert I. Kriebel, Senior Vice President - Finance and
     Administration and Treasurer of U.S. Bioscience, Inc., a corporation
     organized and existing under the Delaware General Corporation Law (the
     "Company"), in accordance with the provisions of Section 151 of such
     law, DO HEREBY CERTIFY that pursuant to the authority conferred upon
     the Board of Directors by the Restated Certificate of Incorporation of
     the Company, the Board of Directors on May 19, 1995 adopted the
     following resolution which creates a series of 500,000 shares of
     Preferred Stock designated as Series A Junior Preferred Stock, as
     follows:

               RESOLVED, that pursuant to Section 151(g) of the Delaware
     General Corporation Law and the authority vested in the Board of
     Directors of the Company in accordance with the provisions of ARTICLE
     FOUR of the Restated Certificate of Incorporation of the Company, a
     series of Preferred Stock of the Company be, and hereby is, created,
     and the powers, designations, preferences and relative, participating,
     optional or other special rights of the shares of such series, and the
     qualifications, limitations or restrictions thereof, be, and hereby
     are, as follows:





















     NYFS02...:\09\78509\0002\1196\CRT4055C.55C
<PAGE>

<PAGE>
     

               Section 1.  Designation and Amount.  The shares of such
                           ----------------------
     series shall be designated as "Series A Junior Preferred Stock" (the
     "Series A Preferred Stock") and the number of shares constituting such
     series shall be 500,000.

               Section 2.  Dividends and Distributions.
                           ---------------------------
               (A)  Subject to the provisions for adjustment hereinafter
     set forth, the holders of shares of Series A Preferred Stock shall be
     entitled to receive, when, as and if declared by the Board of
     Directors out of funds legally available for the purpose, (i) cash
     dividends in an amount per share (rounded to the nearest cent) equal
     to 100 times the aggregate per share amount of all cash dividends
     declared or paid on the Common Stock, $0.005 par value per share, of
     the Company (the "Common Stock") and (ii) a preferential cash dividend
     (the "Preferential Dividends"), if any, in preference to the holders
     of Common Stock, on the first day of February, May, August and
     November of each year (each a "Quarterly Dividend Payment Date"), com-
     mencing on the first Quarterly Dividend Payment Date after the first
     issuance of a share or fraction of a share of Series A Preferred
     Stock, payable in an amount (except in the case of the first Quarterly
     Dividend Payment if the date of the first issuance of Series A
     Preferred Stock is a date other than a Quarterly Dividend Payment
     date, in which case such payment shall be a prorated amount of such
     amount) equal to $1.00 per share of





































     
<PAGE>

<PAGE>
     

     Series A Preferred Stock less the per share amount of all cash
     dividends declared on the Series A Preferred Stock pursuant to clause
     (i) of this sentence since the immediately preceding Quarterly
     Dividend Payment Date or, with respect to the first Quarterly Dividend
     Payment Date, since the first issuance of any share or fraction of a
     share of Series A Preferred Stock.  In the event the Company shall, at
     any time after the issuance of any share or fraction of a share of
     Series A Preferred Stock, make any distribution on the shares of
     Common Stock of the Company, whether by way of a dividend or a
     reclassification of stock, a recapitalization, reorganization or
     partial liquidation of the Company or otherwise, which is payable in
     cash or any debt security, debt instrument, real or personal property
     or any other property (other than cash dividends subject to the imme-
     diately preceding sentence, a distribution of shares of Common Stock
     or other capital stock of the Company or a distribution of rights or
     warrants to acquire any such share, including any debt security
     convertible into or exchangeable for any such share, at a price less
     than the Fair Market Value (as hereinafter defined) of such share),
     then, and in each such event, the Company shall simultaneously pay on
     each then outstanding share of Series A Preferred Stock of the Company
     a distribution, in like kind, of 100 times such distribution paid on a
     share of Common Stock (subject to the provisions for adjustment 
     hereinafter set forth). 





     
<PAGE>

<PAGE>
     

     The dividends and distributions on the Series A Preferred Stock to
     which holders thereof are entitled pursuant to clause (i) of the first
     sentence of this paragraph and pursuant to the second sentence of this
     paragraph are hereinafter referred to as "Dividends" and the multiple
     of such cash and non-cash dividends on the Common Stock applicable to
     the determination of the Dividends, which shall be 100 initially but
     shall be adjusted from time to time as hereinafter provided, is
     hereinafter referred to as the "Dividend Multiple".  In the event the
     Company shall at any time after May 29, 1995 declare or pay any divi-
     dend or make any distribution on Common Stock payable in shares of
     Common Stock, or effect a subdivision or split or a combination,
     consolidation or reverse split of the outstanding shares of Common
     Stock into a greater or lesser number of shares of Common Stock, then
     in each such case the Dividend Multiple thereafter applicable to the
     determination of the amount of Dividends which holders of shares of
     Series A Preferred Stock shall be entitled to receive shall be the
     Dividend Multiple applicable immediately prior to such event
     multiplied by a fraction the numerator of which is the number of
     shares of Common Stock outstanding immediately after such event and
     the denominator of which is the number of shares of Common Stock that
     were outstanding immediately prior to such event.




























     
<PAGE>

<PAGE>
     

               (B)  The Company shall declare each Dividend at the same
     time it declares any cash or non-cash dividend or distribution on the
     Common Stock in respect of which a Dividend is required to be paid. 
     No cash or non-cash dividend or distribution on the Common Stock in
     respect of which a Dividend is required to be paid shall be paid or
     set aside for payment on the Common Stock unless a Dividend in respect
     of such dividend or distribution on the Common Stock shall be simul-
     taneously paid, or set aside for payment, on the Series A Preferred
     Stock.

               (C)  Preferential Dividends shall begin to accrue on
     outstanding shares of Series A Preferred Stock from the Quarterly
     Dividend Payment Date next preceding the date of issuance of any
     shares of Series A Preferred Stock.  Accrued but unpaid Preferential
     Dividends shall cumulate but shall not bear interest.  Preferential
     Dividends paid on the shares of Series A Preferred Stock in an amount
     less than the total amount of such dividends at the time accrued and
     payable on such shares shall be allocated pro rata on a share-by-share
     basis among all such shares at the time outstanding.

               Section 3.  Voting Rights.  The holders of shares of Series
                           -------------
     A Preferred Stock shall have the following voting rights:

               (A)  Subject to the provisions for adjustment hereinafter
     set forth, each share of Series A Preferred Stock shall entitle the
     holder thereof to 100 votes on all matters submitted




























     
<PAGE>

<PAGE>
     

     to a vote of the holders of the Common Stock.  The number of votes
     which a holder of Series A Preferred Stock is entitled to cast, as the
     same may be adjusted from time to time as hereinafter provided, is
     hereinafter referred to as the "Vote Multiple".  In the event the
     Company shall at any time after May 29, 1995 declare or pay any
     dividend on Common Stock payable in shares of Common Stock, or effect
     a subdivision or split or a combination, consolidation or reverse
     split of the outstanding shares of Common Stock into a greater or
     lesser number of shares of Common Stock, then in each such case the
     Vote Multiple thereafter applicable to the determination of the number
     of votes per share to which holders of shares of Series A Preferred
     Stock shall be entitled after such event shall be the Vote Multiple
     immediately prior to such event multiplied by a fraction the numerator
     of which is the number of shares of Common Stock outstanding
     immediately after such event and the denominator of which is the
     number of shares of Common Stock that were outstanding immediately
     prior to such event.

               (B)  Except as otherwise provided herein, in the Restated
     Certificate of Incorporation or By-laws, the holders of shares of
     Series A Preferred Stock and the holders of shares of Common Stock
     shall vote together as one class on all matters submitted to a vote of
     stockholders of the Company.

































     
<PAGE>

<PAGE>
     

               (C)  In the event that the Preferential Dividends accrued on
     the Series A Preferred Stock for four or more quarterly dividend
     periods, whether consecutive or not, shall not have been declared and
     paid or irrevocably set aside for payment, the holders of record of
     Preferred Stock of the Company of all series (including the Series A
     Preferred Stock), other than any series in respect of which such right
     is expressly withheld by the Restated Certificate of Incorporation or
     the authorizing resolutions included in any Certificate of Desig-
     nations therefor, shall have the right, at the next meeting of stock-
     holders called for the election of directors, to elect two members to
     the Board of Directors, which directors shall be in addition to the
     number required by the By-laws prior to such event, to serve until the
     next Annual Meeting and until their successors are elected and
     qualified or their earlier resignation, removal or incapacity or until
     such earlier time as all accrued and unpaid Preferential Dividends
     upon the outstanding shares of Series A Preferred Stock shall have
     been paid (or irrevocably set aside for payment) in full.  The holders
     of shares of Series A Preferred Stock shall continue to have the right
     to elect directors as provided by the immediately preceding sentence
     until all accrued and unpaid Preferential Dividends upon the out-
     standing shares of Series A Preferred Stock shall have been paid (or
     set aside for payment) in full.  Such directors may be removed and
     replaced by such



























     
<PAGE>

<PAGE>
     

     stockholders, and vacancies in such directorships may be filled only
     by such stockholders (or by the remaining director elected by such
     stockholders, if there be one) in the manner permitted by law;
     provided, however, that any such action by stockholders shall be taken
     at a meeting of stockholders and shall not be taken by written consent
     thereto.

               (D)  Except as otherwise required by the Certificate of
     Incorporation or By-laws or set forth herein, holders of Series A
     Preferred Stock shall have no other special voting rights and their
     consent shall not be required (except to the extent they are entitled
     to vote with holders of Common Stock as set forth herein) for the
     taking of any corporate action.

               Section 4.  Certain Restrictions.
                           --------------------

               (A)  Whenever Preferential Dividends or Dividends are in
     arrears or the Company shall be in default of payment thereof,
     thereafter and until all accrued and unpaid Preferential Dividends and
     Dividends, whether or not declared, on shares of Series A Preferred
     Stock outstanding shall have been paid or set irrevocably aside for
     payment in full, and in addition to any and all other rights which any
     holder of shares of Series A Preferred Stock may have in such
     circumstances, the Company shall not

               (i)  declare or pay dividends on, make any other
          distributions on, or redeem or purchase or otherwise acquire for
          consideration, any shares of stock ranking junior






















     
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<PAGE>
     

          (either as to dividends or upon liquidation, dissolution or
          winding up) to the Series A Preferred Stock;

              (ii)  declare or pay dividends on or make any other
          distributions on any shares of stock ranking on a parity as to
          dividends with the Series A Preferred Stock, unless dividends are
          paid ratably on the Series A Preferred Stock and all such parity
          stock on which dividends are payable or in arrears in proportion
          to the total amounts to which the holders of all such shares are
          then entitled if the full dividends accrued thereon were to be
          paid;

             (iii)  except as permitted by subparagraph (iv) of this
          paragraph 4(A), redeem or purchase or otherwise acquire for
          consideration shares of any stock ranking on a parity (either as
          to dividends or upon liquidation, dissolution or winding up) with
          the Series A Preferred Stock, provided that the Company may at
          any time redeem, purchase or otherwise acquire shares of any such
          parity stock in exchange for shares of any stock of the Company
          ranking junior (both as to dividends and upon liquidation,
          dissolution or winding up) to the Series A Preferred Stock; or

              (iv)  purchase or otherwise acquire for consideration any
          shares of Series A Preferred Stock, or any shares of stock
          ranking on a parity with the Series A Preferred Stock (either as
          to dividends or upon liquidation, dissolution or

























     
<PAGE>

<PAGE>
     

          winding up), except in accordance with a purchase offer made to
          all holders of such shares upon such terms as the Board of
          Directors, after consideration of the respective annual dividend
          rates and other relative rights and preferences of the respective
          series and classes, shall determine in good faith will result in
          fair and equitable treatment among the respective series or
          classes.

               (B)  The Company shall not permit any Subsidiary (as
     hereinafter defined) of the Company to purchase or otherwise acquire
     for consideration any shares of stock of the Company unless the
     Company could, under paragraph (A) of this Section 4, purchase or
     otherwise acquire such shares at such time and in such manner.  A
     "Subsidiary" of the Company shall mean any corporation or other entity
     of which securities or other ownership interests having ordinary
     voting power sufficient to elect a majority of the board of directors
     of such corporation or other entity or other persons performing
     similar functions are beneficially owned, directly or indirectly, by
     the Company or by any corporation or other entity that is otherwise
     controlled by the Company.

               (C)  The Company shall not issue any shares of Series A
     Preferred Stock except upon exercise of Rights issued pursuant to that
     certain Rights Agreement dated as of May 19, 1995 between the Company
     and Chemical Mellon Shareholder Services L.L.C., as




























     
<PAGE>

<PAGE>
     

     Rights Agent, a copy of which is on file with the Secretary of the
     Company at its principal executive office and shall be made available
     to stockholders of record without charge upon written request therefor
     addressed to said Secretary.  Notwithstanding the foregoing sentence,
     nothing contained in the provisions hereof shall prohibit or restrict
     the Company from issuing for any purpose any series of Preferred Stock
     with rights and privileges similar to, different from, or greater
     than, those of the Series A Preferred Stock.

               Section 5.  Reacquired Shares.  Any shares of Series A
                           -----------------
     Preferred Stock purchased or otherwise acquired by the Company in any
     manner whatsoever shall be retired and cancelled promptly after the
     acquisition thereof.  All such shares upon their retirement and
     cancellation shall become authorized but unissued shares of Preferred
     Stock, without designation as to series, and such shares may be
     reissued as part of a new series of Preferred Stock to be created by
     resolution or resolutions of the Board of Directors.

               Section 6.  Liquidation, Dissolution or Winding Up.  Upon
                           --------------------------------------
     any voluntary or involuntary liquidation, dissolution or winding up of
     the Company, no distribution shall be made (i) to the holders of
     shares of stock ranking junior (either as to dividends or upon
     liquidation, dissolution or winding up) to the Series A Preferred
     Stock unless the holders of shares of Series A































     
<PAGE>

<PAGE>
     

     Preferred Stock shall have received for each share of Series A
     Preferred Stock, subject to adjustment as hereinafter provided, (A)
     $1,500 plus an amount equal to accrued and unpaid dividends and
     distributions thereon, whether or not declared, to the date of such
     payment or, (B) if greater than the amount specified in clause (i)(A)
     of this sentence, an amount equal to 100 times the aggregate amount to
     be distributed per share to holders of Common Stock, as the same may
     be adjusted as hereinafter provided and (ii) to the holders of stock
     ranking on a parity upon liquidation, dissolution or winding up with
     the Series A Preferred Stock, unless simultaneously therewith
     distributions are made ratably on the Series A Preferred Stock and all
     other shares of such parity stock in proportion to the total amounts
     to which the holders of shares of Series A Preferred Stock are
     entitled under clause (i)(A) of this sentence and to which the holders
     of such parity shares are entitled, in each case upon such liquida-
     tion, dissolution or winding up.  The amount to which holders of
     Series A Preferred Stock may be entitled upon liquidation, dissolution
     or winding up of the Company pursuant to clause (i)(B) of the
     foregoing sentence is hereinafter referred to as the "Participating
     Liquidation Amount" and the multiple of the amount to be distributed
     to holders of shares of Common Stock upon the liquidation, dissolution
     or winding up of the Company applicable pursuant to said clause to the
     determination of the Participating






























     
<PAGE>

<PAGE>
     

     Liquidation Amount, as said multiple may be adjusted from time to time
     as hereinafter provided, is hereinafter referred to as the
     "Liquidation Multiple".  In the event the Company shall at any time
     after May 29, 1995 declare or pay any dividend on Common Stock payable
     in shares of Common Stock, or effect a subdivision or split or a com-
     bination, consolidation or reverse split of the outstanding shares of
     Common Stock into a greater or lesser number of shares of Common
     Stock, then, in each such case, the Liquidation Multiple thereafter
     applicable to the determination of the Participating Liquidation
     Amount to which holders of Series A Preferred Stock shall be entitled
     after such event shall be the Liquidation Multiple applicable
     immediately prior to such event multiplied by a fraction the numerator
     of which is the number of shares of Common Stock outstanding
     immediately after such event and the denominator of which is the
     number of shares of Common Stock that were outstanding immediately
     prior to such event.

               Section 7.  Certain Reclassifications and Other Events.
                           ------------------------------------------
               (A)  In the event that holders of shares of Common Stock of
     the Company receive after May 29, 1995 in respect of their shares of
     Common Stock any share of capital stock of the Company (other than any
     share of Common Stock of the Company), whether by way of reclassi-
     fication, recapitalization, reorganization, dividend or other
     distribution or otherwise (a "Trans



































     
<PAGE>

<PAGE>
     

     action"), then, and in each such event, the dividend rights, voting
     rights and rights upon the liquidation, dissolution or winding up of
     the Company of the shares of Series A Preferred Stock shall be
     adjusted so that after such event the holders of Series A Preferred
     Stock shall be entitled, in respect of each share of Series A
     Preferred Stock held, in addition to such rights in respect thereof to
     which such holder was entitled immediately prior to such adjustment,
     to (i) such additional dividends as equal the Dividend Multiple in
     effect immediately prior to such Transaction multiplied by the
     additional dividends which the holder of a share of Common Stock shall
     be entitled to receive by virtue of the receipt in the Transaction of
     such capital stock, (ii) such additional voting rights as equal the
     Vote Multiple in effect immediately prior to such Transaction
     multiplied by the additional voting rights which the holder of a share
     of Common Stock shall be entitled to receive by virtue of the receipt
     in the Transaction of such capital stock and (iii) such additional
     distributions upon liquidation, dissolution or winding up of the
     Company as equal the Liquidation Multiple in effect immediately prior
     to such Transaction multiplied by the additional amount which the
     holder of a share of Common Stock shall be entitled to receive upon
     liquidation, dissolution or winding up of the Company by virtue of the
     receipt in the






































     
<PAGE>

<PAGE>
     

     Transaction of such capital stock, as the case may be, all as provided
     by the terms of such capital stock.

               (B)  In the event that holders of shares of Common Stock of
     the Company receive after May 29, 1995 in respect of their shares of
     Common Stock any right or warrant to purchase Common Stock (including
     as such a right, for all purposes of this paragraph, any security con-
     vertible into or exchangeable for Common Stock) at a purchase price
     per share less than the Fair Market Value of a share of Common Stock
     on the date of issuance of such right or warrant, then and in each
     such event the dividend rights, voting rights and rights upon the
     liquidation, dissolution or winding up of the Company of the shares of
     Series A Preferred Stock shall each be adjusted so that after such
     event the Dividend Multiple, the Vote Multiple and the Liquidation
     Multiple shall each be the product of the Dividend Multiple, the Vote
     Multiple and the Liquidation Multiple, as the case may be, in effect
     immediately prior to such event multiplied by a fraction the numerator
     of which shall be the number of shares of Common Stock outstanding
     immediately before such issuance of rights or warrants plus the
     maximum number of shares of Common Stock which could be acquired upon
     exercise in full of all such rights or warrants and the denominator of
     which shall be the number of shares of Common Stock outstanding
     immediately before such issuance of rights or warrants plus the number
     of shares of


 
<PAGE>

<PAGE>
     

     Common Stock which could be purchased, at the Fair Market Value of the
     Common Stock at the time of such issuance, by the maximum aggregate
     consideration payable upon exercise in full of all such rights or
     warrants.

               (C)  In the event that holders of shares of Common Stock of
     the Company receive after May 29, 1995 in respect of their shares of
     Common Stock any right or warrant to purchase capital stock of the
     Company (other than shares of Common Stock), including as such a
     right, for all purposes of this paragraph, any security convertible
     into or exchangeable for capital stock of the Company (other than
     Common Stock), at a purchase price per share less than the Fair Market
     Value of such shares of capital stock on the date of issuance of such
     right or warrant, then and in each such event the dividend rights,
     voting rights and rights upon liquidation, dissolution or winding up
     of the Company of the shares of Series A Preferred Stock shall each be
     adjusted so that after such event each holder of a share of Series A
     Preferred Stock shall be entitled, in respect of each share of Series
     A Preferred Stock held, in addition to such rights in respect thereof
     to which such holder was entitled immediately prior to such event, to
     receive (i) such additional dividends as equal the Dividend Multiple
     in effect immediately prior to such event multiplied, first, by the
     additional dividends to which the holder of a share of Common Stock
     shall be entitled upon exercise
























     
<PAGE>

<PAGE>
     

     of such right or warrant by virtue of the capital stock which could be
     acquired upon such exercise and multiplied again by the Discount
     Fraction (as hereinafter defined) and (ii) such additional voting
     rights as equal the Vote Multiple in effect immediately prior to such
     event multiplied, first, by the additional voting rights to which the
     holder of a share of Common Stock shall be entitled upon exercise of
     such right or warrant by virtue of the capital stock which could be
     acquired upon such exercise and multiplied again by the Discount
     Fraction and (iii) such additional distributions upon liquidation,
     dissolution or winding up of the Company as equal the Liquidation
     Multiple in effect immediately prior to such event multiplied, first,
     by the additional amount which the holder of a share of Common Stock
     shall be entitled to receive upon liquidation, dissolution or winding
     up of the Company upon exercise of such right or warrant by virtue of
     the capital stock which could be acquired upon such exercise and
     multiplied again by the Discount Fraction.  For purposes of this
     paragraph, the "Discount Fraction" shall be a fraction the numerator
     of which shall be the difference between the Fair Market Value of a
     share of the capital stock subject to a right or warrant distributed
     to holders of shares of Common Stock of the Company as contemplated by
     this paragraph immediately after the distribution thereof and the
     purchase price per share for such share of capital stock pursuant to
     such right or







     
<PAGE>

<PAGE>
     

     warrant and the denominator of which shall be the Fair Market Value of
     a share of such capital stock immediately after the distribution of
     such right or warrant.

               (D)  For purposes of this Certificate of Designations, the
     "Fair Market Value" of a share of capital stock of the Company (in-
     cluding a share of Common Stock) on any date shall be deemed to be the
     average of the daily closing price per share thereof over the 30
     consecutive Trading Days (as such term is hereinafter defined)
     immediately prior to such date; provided, however, that, in the event
     that such Fair Market Value of any such share of capital stock is
     determined during a period which includes any date that is within 30
     Trading Days after (i) the ex-dividend date for a dividend or distri-
     bution on stock payable in shares of such stock or securities
     convertible into shares of such stock, or (ii) the effective date of
     any subdivision, split, combination, consolidation, reverse stock
     split or reclassification of such stock, then, and in each such case,
     the Fair Market Value shall be appropriately adjusted by the Board of
     Directors of the Company to take into account ex-dividend or post-
     effective date trading.  The closing price for any day shall be the
     last sale price, regular way, or, in case, no such sale takes place on
     such day, the average of the closing bid and asked prices, regular way
     (in either case, as reported in the applicable transaction reporting
     system with respect to securities listed or





  
<PAGE>

<PAGE>
     

     admitted to trading on the New York Stock Exchange), or, if the shares
     are not listed or admitted to trading on the New York Stock Exchange,
     as reported in the applicable transaction reporting system with
     respect to securities listed on the principal national securities
     exchange on which the shares are listed or admitted to trading or, if
     the shares are not listed or admitted to trading on any national secu-
     rities exchange, the last quoted price or, if not so quoted, the
     average of the high bid and low asked prices in the over-the-counter
     market, as reported by the National Association of Securities Dealers,
     Inc. Automated Quotation System ("NASDAQ") or such other system then
     in use, or if on any such date the shares are not quoted by any such
     organization, the average of the closing bid and asked prices as furn-
     ished by a professional market maker making a market in the shares
     selected by the Board of Directors of the Company.  The term "Trading
     Day" shall mean a day on which the principal national securities
     exchange on which the shares are listed or admitted to trading is open
     for the transaction of business or, if the shares are not listed or
     admitted to trading on any national securities exchange, on which the
     New York Stock Exchange or such other national securities exchange as
     may be selected by the Board of Directors of the Company is open.  If
     the shares are not publicly held or not so listed or traded on any day
     within the period of 30 Trading Days applicable to the





     
<PAGE>

<PAGE>
     

     determination of Fair Market Value thereof as aforesaid, "Fair Market
     Value" shall mean the fair market value thereof per share as
     determined in good faith by the Board of Directors of the Company.  In
     either case referred to in the foregoing sentence, the determination
     of Fair Market Value shall be described in a statement filed with the
     Secretary of the Company.

               Section 8.  Consolidation, Merger, etc.  In case the Company
                           ---------------------------
     shall enter into any consolidation, merger, combination or other
     transaction in which the shares of Common Stock are exchanged for or
     changed into other stock or securities, cash and/or any other
     property, then in any such case each outstanding share of Series A
     Preferred Stock shall at the same time be similarly exchanged for or
     changed into the aggregate amount of stock, securities, cash and/or
     other property (payable in like kind), as the case may be, for which
     or into which each share of Common Stock is changed or exchanged
     multiplied by the highest of the Vote Multiple, the Dividend Multiple
     or the Liquidation Multiple in effect immediately prior to such event.

               Section 9.  Effective Time of Adjustments.
                           -----------------------------

               (A)  Adjustments to the Series A Preferred Stock required by
     the provisions hereof shall be effective as of the time at which the
     event requiring such adjustments occurs.

               (B)  The Company shall give prompt written notice to each
     holder of a share of Series A Preferred Stock of the effect



















     
<PAGE>

<PAGE>
     

     of any adjustment to the voting rights, dividend rights or rights upon
     liquidation, dissolution or winding up of the Company of such shares
     required by the provisions hereof.  Notwithstanding the foregoing
     sentence, the failure of the Company to give such notice shall not
     affect the validity of or the force or effect of or the requirement
     for such adjustment.

               Section 10.  No Redemption.  The shares of Series A
                            -------------
     Preferred Stock shall not be redeemable at the option of the Company
     or any holder thereof.  Notwithstanding the foregoing sentence of this
     Section, the Company may acquire shares of Series A Preferred Stock in
     any other manner permitted by law, the provisions hereof and the
     Restated Certificate of Incorporation of the Company.

               Section 11.  Ranking.  Unless otherwise provided in the
                            -------
     Certificate of Incorporation of the Company or a Certificate of
     Designations relating to a subsequent series of preferred stock of the
     Company, the Series A Preferred Stock shall rank junior to all other
     series of the Company's preferred stock as to the payment of dividends
     and the distribution of assets on liquidation, dissolution or winding
     up and senior to the Common Stock.

               Section 12.  Amendment.  The provisions hereof and the
                            ---------
     Certificate of Incorporation of the Company shall not be amended in
     any manner which would adversely affect the rights, privileges or
     powers of the Series A Preferred Stock without, in addition to



 
<PAGE>

<PAGE>
     

     any other vote of stockholders required by law, the affirmative vote
     of the holders of two-thirds or more of the outstanding shares of
     Series A Preferred Stock, voting together as a single class.

               IN WITNESS WHEREOF, I have executed and subscribed this
     Certificate of Designations and do affirm the foregoing as true under
     the penalties of perjury this      day of June, 1995.
                                   ----


                                        -------------------------
                                        Robert I. Kriebel  
                                        Senior Vice President -
                                        Finance and Administration
                                        and Treasurer 
                                               

     ATTEST:


     --------------------------











































<PAGE>
                                                              US
NEWS                                                  BIOSCIENCE
                                      One Tower Bridge
                                      100 Front Street
                                      West Conshohocken, PA 19428

Contact: Robert I. Kriebel, Sr. Vice President
Finance and Administration
U.S. Bioscience
(610) 832-0570


                                       FOR IMMEDIATE RELEASE
                                       ---------------------

     U.S. BIOSCIENCE, INC. BOARD ADOPTS RIGHTS PLAN

WEST CONSHOHOCKEN, PA, MAY 19, 1995 -- U.S. BIOSCIENCE, INC. (AMEX:UBS)
announced today that its Board of Directors has adopted a Rights Plan
designed to protect company stockholders in the event of takeover
action that would deny them the full value of their investment.

Terms of the rights plan provide for a dividend distribution of one
right for each share of Common Stock of U.S. Bioscience, Inc. to
holders of record at the close of business on May 29, 1995. The
rights will become exercisable only in the event, with certain
exceptions, an aquiring party accumulates 15 percent or more of U.S.
Bioscience's voting stock, or if a party announces an offer to aquire 
30 percent or more. The rights will expire on May 29, 2005. Each right
will entitle the holder to buy one one-hundreth of a share of a new series
of preferred stock at a price of $15. In addition, upon the occurence
of certain events, holders of the rights will be entitled to purchase 
either U.S. Bioscience stock or shares in an "acquiring entity" at 
half of market value.

U.S. Bioscience will generally be entitled to redeem the rights at one-
tenth of one cent ($.001) per right at any time until the tenth day 
following the acquisition of a 15 percent position in its voting stock.

Details of the new Rights Plan will be outlined in a letter to be mailed
to stockholders. 

Based in West Conshohocken, Pennsylvania, U.S. Bioscience is a 
pharmaceutical company specializing in the development and
commercialization of products for patients with cancer and AIDS.



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