U S BIOSCIENCE INC
8-A12B/A, 1995-07-20
PHARMACEUTICAL PREPARATIONS
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                          SECURITIES AND EXCHANGE COMMISSION
                                Washington, D.C. 20549
                                                    
                                 -------------------

                                      FORM 8-A/A
                                      AMENDMENT
                  FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES
                      PURSUANT TO SECTION 12(b) OR 12(g) OF THE
                           SECURITIES EXCHANGE ACT OF 1934
                                                 
                                    -------------

                                   Amendment No. 1


                                U.S. Bioscience, Inc.
     ---------------------------------------------------------------------------
                (Exact Name of Registrant as Specified in its Charter)

                Delaware                                    23-2460100
     ------------------------------               ------------------------------
         (State of Incorporation                         (I.R.S. Employer
            or Organization)                            Identification No.)

                    One Tower Bridge
                    100 Front Street
            West Conshohocken, Pennsylvania                         14428
     ---------------------------------------------          --------------------
            (Address and Telephone Number of                     (Zip Code)
              Principal Executive Offices)


     If this Form relates to the registration of a class of debt securities and
     is effective upon filing pursuant to General Instruction A(c)(1) please
     check the following box. [_]


     If this Form relates to the registration of a class of debt securities and
     is to become effective simultaneously with the effectiveness of a
     concurrent registration statement under the Securities Act of 1933 pursuant
     to General Instruction A(c)(2) please check the following box. [_]

          Securities to be registered pursuant to Section 12(b) of the Act:


           Title of Each Class                    Name of Each Exchange on Which
           to be so Registered                    Each Class is to be Registered
     ------------------------------               ------------------------------

     Preferred Stock Purchase                     American Stock Exchange
     Rights                                       ("AMEX")


          Securities to be registered pursuant to Section 12(g) of the Act:

                                         None
     ---------------------------------------------------------------------------
                                   (Title of Class)
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     Item 1.  Description of Securities to be Registered.
              ------------------------------------------

               On May 19, 1995, the Board of Directors of the Company
     declared a dividend of one Preferred Stock Purchase Right (the
     "Right(s)") for each outstanding share of Common Stock, par value
     $0.005 per share (the "Common Stock"), of the Company.  The dividend
     is payable as of May 29, 1995 to stockholders of record on that date. 
     Each Right entitles the registered holder to purchase from the Company
     one one-hundredth (1/100) of a share of a new series of preferred
     shares of the Company, designated as Series A Junior Preferred Stock
     ("Preferred Stock"), at a price of $15 per one one-hundredth (1/100)
     of a share (the "Exercise Price"), subject to certain adjustments. 
     The description and terms of the Rights are set forth in a Rights
     Agreement, dated as of May 19, 1995 (the "Rights Agreement"), between
     the Company and Chemical Mellon Shareholder Services L.L.C., as Rights
     Agent ("Rights Agent").

               Initially the Rights will not be exercisable, certificates
     will not be sent to stockholders, and the Rights will automatically
     trade with the Common Stock.

               The Rights, unless earlier redeemed by the Board of
     Directors, become exercisable upon the close of business on the day
     (the "Distribution Date") which is the earlier of (i) the tenth day
     following a public announcement that a person or group of affiliated
     or associated persons, with certain exceptions set forth below, has
     acquired beneficial ownership of 15% or more of the outstanding voting
     stock of the Company (an "Acquiring Person") and (ii) the tenth
     business day (or such later date as may be determined








































     NYFS02...:\09\78509\0002\1196\FRM7065R.270
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     by the Board of Directors prior to such time as any person or group of
     affiliated or associated persons becomes an Acquiring Person) after
     the date of the commencement or announcement of a person's or group's
     intention to commence a tender or exchange offer the consummation of
     which would result in the ownership of 30% or more of the Company's
     outstanding voting stock (even if no shares are actually purchased
     pursuant to such offer); prior thereto, the Rights would not be
     exercisable, would not be represented by a separate certificate, and
     would not be transferable apart from the Company's Common Stock, but
     will instead be evidenced, with respect to any of the Common Stock
     certificates outstanding as of May 29, 1995, by such Common Stock
     certificate with a copy of this Summary of Rights attached thereto. 
     An Acquiring Person does not include (A) the Company, (B) any
     subsidiary of the Company, (C) any employee benefit plan or employee
     stock plan of the Company or of any subsidiary of the Company, or any
     trust or other entity organized, appointed, established or holding
     Common Stock for or pursuant to the terms of any such plan or (D) any
     person or group whose ownership of 15% or more of the shares of voting
     stock of the Company then outstanding results solely from (i) any
     action or transaction or transactions approved by the Board of
     Directors before such person or group became an Acquiring Person or
     (ii) a reduction in the number of issued and outstanding shares of
     voting stock of the Company pursuant to a transaction or transactions
     approved by the Board of Directors (provided that any person or group
     that does not become an Acquiring Person by reason of clause (i) or
     (ii) above shall become an Acquiring Person upon acquisition of an









































     
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     additional 1% of the Company's voting stock unless such acquisition of
     additional voting stock will not result in such person or group
     becoming an Acquiring Person by reason of such clause (i) or (ii)). 

               Until the Distribution Date (or earlier redemption or
     expiration of the Rights), new Common Stock certificates issued after
     May 29, 1995 will contain a legend incorporating the Rights Agreement
     by reference.  Until the Distribution Date (or earlier redemption or
     expiration of the Rights), the surrender for transfer of any of the
     Company's Common Stock certificates outstanding as of May 29, 1995
     with or without a copy of the Summary of Rights attached, will also
     constitute the transfer of the Rights associated with the Common Stock
     represented by such certificate.  As soon as practicable following the
     Distribution Date, separate certificates evidencing the Rights ("Right
     Certificates") will be mailed to holders of record of the Company's
     Common Stock as of the close of business on the Distribution Date and
     such separate certificates alone will evidence the Rights from and
     after the Distribution Date.

               The Rights are not exercisable until the Distribution Date. 
     The Rights will expire at the close of business on May 19, 2005,
     unless earlier redeemed by the Company as described below.

               The Preferred Stock is non-redeemable and, unless otherwise
     provided in connection with the creation of a subsequent series of
     preferred stock, subordinate to any other series of the Company's
     preferred stock.  The Preferred Stock may not be issued













































     
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     except upon exercise of Rights.  Each share of Preferred Stock will be
     entitled to receive when, as and if declared, a quarterly dividend in
     an amount equal to the greater of $1.00 per share and 100 times the
     cash dividends declared on the Company's Common Stock.  In addition,
     the Preferred Stock is entitled to 100 times any non-cash dividends
     (other than dividends payable in equity securities) declared on the
     Common Stock, in like kind.  In the event of liquidation, the holders
     of Preferred Stock will be entitled to receive for each share of
     Series A Preferred Stock, a liquidation payment in an amount equal to
     the greater of $1,500 or 100 times the payment made per share of
     Common Stock.  Each share of Preferred Stock will have 100 votes,
     voting together with the Common Stock.  In the event of any merger,
     consolidation or other transaction in which Common Stock is exchanged,
     each share of Preferred Stock will be entitled to receive 100 times
     the amount received per share of Common Stock.  The rights of
     Preferred Stock as to dividends, liquidation and voting are protected
     by anti-dilution provisions.

               The number of shares of Preferred Stock issuable upon
     exercise of the Rights is subject to certain adjustments from time to
     time in the event of a stock dividend on, or a subdivision or
     combination of, the Common Stock.  The Exercise Price for the Rights
     is subject to adjustment in the event of extraordinary distributions
     of cash or other property to holders of Common Stock.

               Unless the Rights are earlier redeemed or the transaction is
     approved by the Board of Directors and the Continuing Directors, in
     the event that, after the time that the







































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     Rights become exercisable, the Company were to be acquired in a merger
     or other business combination (in which any shares of the Company's
     Common Stock are changed into or exchanged for other securities or
     assets) or more than 50% of the assets or earning power of the Company
     and its subsidiaries (taken as a whole) were to be sold or transferred
     in one or a series of related transactions, the Rights Agreement
     provides that proper provision will be made so that each holder of
     record of a Right will from and after such date have the right to
     receive, upon payment of the Exercise Price, that number of shares of
     common stock of the acquiring company having a market value at the
     time of such transaction equal to two times the Exercise Price.  In
     addition, unless the Rights are earlier redeemed, if a person or group
     (with certain exceptions) becomes the beneficial owner of 15% or more
     of the Company's voting stock (other than pursuant to a tender or
     exchange offer (a "Qualifying Tender Offer") for all outstanding
     shares of Common Stock that is approved by the Board of Directors,
     after taking into account the long-term value of the Company and all
     other factors they consider relevant in the circumstances), the Rights
     Agreement provides that proper provision will be made so that each
     holder of record of a Right, other than the Acquiring Person (whose
     Rights will thereupon become null and void), will thereafter have the
     right to receive, upon payment of the Exercise Price, that number of
     shares of the Company's Preferred Stock having a market value at the
     time of the transaction equal to two times the Exercise Price (such
     market value to be determined with reference to the market value of
     the Company's Common Stock as provided in the Rights Agreement).





























     
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               Fractions of shares of Preferred Stock (other than fractions
     that are integral multiples of one one-hundredth (1/100) of a share)
     may, at the election of the Company, be evidenced by depositary
     receipts.  The Company may also issue cash in lieu of fractional
     shares which are not integral multiples of one one-hundredth (1/100)
     of a share.

               At any time on or prior to the close of business on the
     tenth day after the time that a person has become an Acquiring Person
     (or such later date as a majority of the Board of Directors and a
     majority of the Continuing Directors (as defined in the Rights
     Agreement) may determine), the Company may redeem the Rights in whole,
     but not in part, at a price of $.001 per Right ("Redemption Price"). 
     The Rights may be redeemed after the time that any Person has become
     an Acquiring Person only if approved by a majority of the Continuing
     Directors.  Immediately upon the effective time of the action of the
     Board of Directors of the Company authorizing redemption of the
     Rights, the right to exercise the Rights will terminate and the only
     right of the holders of the Rights will be to receive the Redemption
     Price.

               For as long as the Rights are then redeemable, the Company
     may, except with respect to the redemption price or date of expiration
     of the Rights, amend the Rights in any manner, including an amendment
     to extend the time period in which the Rights may be redeemed.  At any
     time when the Rights are not then redeemable, the Company may amend
     the Rights in any manner that does not materially adversely affect the
     interests of holders of the Rights as such.  Amendments to the Rights
     Agreement from and after the time that any








































     
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     Person becomes an Acquiring Person requires the approval of a majority
     of the Continuing Directors (as provided in the Rights Agreement).

               Until a Right is exercised, the holder, as such, will have
     no rights as a stockholder of the Company, including, without
     limitation, the right to vote or to receive dividends.

               As of March 15, 1995 there were 40,770,780 shares of Common
     Stock issued and outstanding (and 7,341,342 and 1,096,634 shares
     reserved for issuance under the Company's existing stock option plans
     and warrants, respectively).  500,000 shares of Preferred Stock have
     been reserved for issuance upon exercise of the Rights.

               The Rights have certain anti-takeover effects.  The Rights
     will cause substantial dilution to a person or group who attempts to
     acquire the Company on terms not approved by the Company's Board of
     Directors.  The Rights should not interfere with any merger or other
     business combination approved by the Board since they may be redeemed
     by the Company at $.001 per Right at any time until the close of
     business on the tenth day (or such later date as described above)
     after a person or group has obtained beneficial ownership of 15% or
     more of the voting stock.

               The form of Rights Agreement between the Company and
     Chemical Mellon Shareholder Services, L.L.C., as rights agent,
     specifying the terms of the Rights, which includes as Exhibit A the
     form of Summary of Rights to Purchase Series A Junior Preferred Stock,
     as Exhibit B the form of Right Certificate and as Exhibit C the form
     of Certificate of










































     
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     Designations of the Company setting forth the terms of the Preferred
     Stock are incorporated herein by reference to the Company's Current
     Report on Form 8-K dated the date hereof.  The foregoing description
     of the Rights is qualified by reference to such exhibits.






































































     
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     Item 2.  Exhibits.
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               1.   Rights Agreement dated as of May 19, 1995 between U.S.
                    Bioscience, Inc.and Chemical Mellon Shareholder
                    Services L.L.C. as Rights Agent (Incorporated by
                    reference to the Company's Form 8-K, dated May 19,
                    1995).

               2.   Letter to Stockholders, dated June 7, 1995
                    (Incorporated by reference to the Company's Form 8-A,
                    dated June 7, 1995).
























































     
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                                   SIGNATURES
                                   ----------

               Pursuant to the requirements of Section 12 of the Securities
     Exchange Act of 1934, the registrant has duly caused this registration
     statement to be signed on its behalf by the undersigned hereunto duly
     authorized.

                                   U.S. BIOSCIENCE, INC.

                                   By: /s/ Robert I. Kriebel               
                                      -------------------------------------
                                   Name:   Robert I. Kriebel
                                   Title:  Senior Vice President  
                                              


     July 20, 1995




















































     
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                                  EXHIBIT INDEX


     Exhibit No.         Description                                   Page
     ----------          -----------                                   ----

          1.        Rights Agreement dated as of May 19, 1995 between
                    U.S. Bioscience, Inc. and Chemical Mellon
                    Shareholder Services L.L.C. as Rights Agent
                    (Incorporated by reference to the Company's Form
                    8-K, dated May 19, 1995).

          2.        Letter to Stockholders, dated June 7, 1995
                    (Incorporated by reference to the Company's Form 8-A,
                    dated June 7, 1995).


























































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