As filed with the Securities and Exchange Commission
via the EDGAR system on June 5, 1998
Registration No. 33-77376
=================================================================
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
-------------
POST-EFFECTIVE AMENDMENT NO. 1
TO
FORM S-3
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
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U.S. BIOSCIENCE, INC.
(Exact Name of Registrant as Specified in its Charter)
DELAWARE 23-2460100
(State or other jurisdiction of (I.R.S. Employer
incorporation or organization) Identification Number)
ONE TOWER BRIDGE
100 FRONT STREET
WEST CONSHOHOCKEN, PA 19428
(610) 832-0570
(Address, including zip code, and telephone number, including
area code, of Registrant's principal executive offices)
-------------
ROBERT I. KRIEBEL
EXECUTIVE VICE PRESIDENT
U.S. BIOSCIENCE, INC.
ONE TOWER BRIDGE
100 FRONT STREET
WEST CONSHOHOCKEN, PA 19428
(610) 832-0570
(Name, address, including zip code, and telephone number,
including area code, of agent for service)
-------------
COPIES TO:
ALAN H. MOLOD, ESQUIRE
WOLF, BLOCK, SCHORR AND SOLIS-COHEN LLP
TWELFTH FLOOR PACKARD BUILDING
S.E. CORNER 15TH & CHESTNUT STREETS
PHILADELPHIA, PA 19102
=================================================================<PAGE>
<PAGE>
This post-effective amendment is being filed, in
accordance with the Registrant's undertaking to do so, solely
to deregister 1,095,674 shares of U.S. Bioscience, Inc. common
stock, which were registered on this Registration Statement.<PAGE>
<PAGE>
SIGNATURES
Pursuant to the requirements of the Securities Act of
1933, the Registrant has duly caused this Post-effectiveAmendment
No. 1 to the Registration Statement to be signed on its behalf by
the undersigned, thereunto duly authorized, in the city of West
Conshohocken, State of Pennsylvania, on June 3, 1998.
U.S. BIOSCIENCE, INC.
By:/s/ Robert I. Kriebel
------------------------
Robert I. Kriebel
Executive Vice President
Pursuant to the requirements of the Securities Act of
1933, this Post-effectiveAmendment No. 1 Registration Statement
has been signed by the following persons, in the capacities
indicated below, on June 3, 1998.
Signature Title
--------- -----
/s/ C. Boyd Clarke Principal Executive Officer
- --------------------- and Director
C. Boyd Clarke
/s/ Robert I. Kriebel Principal Financial Officer
- --------------------- and Director
Robert I. Kriebel
* Principal Accounting Officer
- ---------------------
Mark R. Bausinger
* Director
- ---------------------
Robert L. Capizzi, M.D.
* Director
- ---------------------
Paul Calabresi, M.D.
* Director
- ---------------------
Betsey Wright
* Director
- ---------------------
Allen Misher, Ph.D.
* Director
- ---------------------
Douglas J. MacMaster, Jr.
- -----------------------------------------
* By:/s/ Robert I. Kriebel
---------------------
Robert I. Kriebel
Attorney-in-fact
