CUSIP No. 911646 20 6 Page 1 of 44 Pages
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13D
(Rule 13d-101)
INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
RULE 13d-2(a)
(Amendment No. )1 [fn]
U.S. Bioscience, Inc.
(Name of Issuer)
Common Stock, $.01 par value
(Title of Class of Securities)
911646 20 6
(CUSIP Number)
Kathleen K. Schoemaker John C. MacMurray, Esq.
Domain Associates Reboul, MacMurray, Hewitt,
One Palmer Square Maynard & Kristol
Princeton, New Jersey 08452 45 Rockefeller Plaza
Te. (609) 683-5656 New York, New York 10111
Tel. (212) 841-5700
(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)
January 27, 1999
(Date of Event Which Requires Filing of This Statement)
If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following
box [ ].
- --------
[fn]
1The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page. The information required on the
remainder of this cover page shall not be deemed to be "filed" for the purpose
of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the
liabilities of that section of the Act but shall be subject to all other
provisions of the Act.
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CUSIP No. 911646 20 6 Page 2 of 44 Pages
1) Name of Reporting Person Domain Partners
I.R.S. Identification IV, L.P.
No. of Above Person
(If an Entity)
2) Check the Appropriate Box (a) [x]
if a Member of a Group (b) [ ]
3) SEC Use Only
4) Source of Funds WC
5) Check if Disclosure of
Legal Proceedings is Not Applicable
Required Pursuant to
Items 2(d) or 2(e)
6) Citizenship or Place
of Organization Delaware
Number of 7) Sole Voting 2,833,760 shares of
Shares Beneficially Power Common Stock
Owned by Each (Including shares
Reporting Person issuable upon
With exercise of warrants)
8) Shared Voting
Power -0-
9) Sole Disposi- 2,833,760 shares of
tive Power Common Stock
(Including shares
issuable upon
exercise of warrants)
10) Shared Dis-
positive Power -0-
11) Aggregate Amount Beneficially 2,833,760 shares of
Owned by Each Reporting Person Common Stock
(Including shares
issuable upon
exercise of warrants)
12) Check if the Aggregate
Amount in Row (11)
Excludes Certain Shares
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CUSIP No. 911646 20 6 Page 3 of 44 Pages
13) Percent of Class
Represented by 10.3%
Amount in Row (11)
14) Type of Reporting
Person PN
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CUSIP No. 911646 20 6 Page 4 of 44 Pages
1) Name of Reporting Person DP IV Associates,
I.R.S. Identification L.P.
No. of Above Person
(If an Entity)
2) Check the Appropriate Box (a) [x]
if a Member of a Group (b) [ ]
3) SEC Use Only
4) Source of Funds WC
5) Check if Disclosure of
Legal Proceedings is Not Applicable
Required Pursuant to
Items 2(d) or 2(e)
6) Citizenship or Place
of Organization Delaware
Number of 7) Sole Voting 67,906 shares of
Shares Beneficially Power Common Stock
Owned by Each (Including shares
Reporting Person issuable upon
With exercise of warrants)
8) Shared Voting
Power -0-
9) Sole Disposi- 67,906 shares of
tive Power Common Stock
(Including shares
issuable upon
exercise of warrants)
10)Shared Dis-
positive Power -0-
11) Aggregate Amount Beneficially 67,906 shares of
Owned by Each Reporting Person Common Stock
(Including shares
issuable upon
exercise of warrants)
12) Check if the Aggregate
Amount in Row (11)
Excludes Certain Shares
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CUSIP No. 911646 20 6 Page 5 of 44 Pages
13) Percent of Class
Represented by 0.3%
Amount in Row (11)
14) Type of Reporting
Person PN
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CUSIP No. 911646 20 6 Page 6 of 44 Pages
Schedule 13D
Item 1. Security and Issuer.
This statement relates to the Common Stock, $.01 par value (the
"Common Stock") of U.S. Bioscience, Inc., a Delaware corporation ("USB" or the
"Issuer"). The principal executive offices of the Issuer are located at 100
Front Street, One Tower Bridge, West Conshohocken, Pennsylvania 19428.
Item 2. Identity and Background.
(a) Pursuant to Rules 13d-1(k(1)-(2) of Regulation 13D-G of the
General Rules and Regulations under the Securities Act of 1934, as amended (the
"Act"), the undersigned hereby file this Schedule 13D on behalf of Domain
Partners IV, L.P., a Delaware limited partnership ("DP IV"), and DP IV
Associates, L.P., a Delaware limited partnership ("DP IV A"). DP IV and DP IV A
are sometimes hereinafter referred to as the "Reporting Persons". The Reporting
Persons are making this single joint filing because they may be deemed to
constitute a "group" within the meaning of Section 13(d)(3) of the Act. The
agreement between the Reporting Persons to file as a group (the "Group
Agreement") is attached hereto as Exhibit A.
(b)-(c) DP IV and DP IV A are Delaware limited partnerships, each of
whose principal business is that of a private investment partnership. The sole
general partner of DP IV and DP IV A is One Palmer Square Associates IV, L.L.C.,
a Delaware limited liability company ("OPSA IV"), whose principal business is
that of acting as the general partner of DP IV and DP IV A. The following
individuals, who are citizens of the United States, are the managing members of
OPSA IV:
(i) James C. Blair
(ii) Brian H. Dovey
(iii) Jesse I. Treu
(iv) Kathleen K. Schoemaker
(v) Arthur Klausner
The principal business and principal office address of each entity and
person named in this paragraph is One Palmer Square, Princeton, New Jersey
08542.
(d) None of the entities or persons identified in this Item 2 has,
during the last five years, been convicted in a criminal proceeding (excluding
traffic violations or similar misdemeanors).
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CUSIP No. 911646 20 6 Page 7 of 44 Pages
(e) None of the entities or persons identified in this Item 2 has,
during the last five years, been a party to a civil proceeding of a judicial or
administrative body of competent jurisdiction and as a result of such proceeding
was or is subject to a judgment, decree or final order enjoining future
violations of, or prohibiting or mandating activities subject to, federal or
state securities laws or finding any violation with respect to such laws.
Item 3. Source and Amount of Funds or Other Consideration.
This statement relates to the acquisition by the Reporting Persons of
an aggregate 2,418,055 shares of Common Stock (the "Shares") and warrants to
purchase an aggregate 483,611 shares of Common Stock at an exercise price of
$11.17 per share (the "Warrants"), in a private placement offering by the Issuer
(the "Private Placement"), pursuant to a Securities Purchase Agreement made as
of January 27, 1999 by and among the Issuer and the purchasers named therein,
including the Reporting Persons (the "Purchase Agreement"). The Purchase
Agreement is attached hereto as Exhibit B, and any description thereof is
qualified in its entirety by reference thereto. The Warrants are exercisable
immediately and expire on January 27, 2002. A Form of Warrant is attached hereto
as Exhibit A to the Purchase Agreement. The aggregate purchase price for the
Shares and Warrants was $18,000,001.42, and the source of such funds was the
working capital, or funds available for investment, of the Reporting Persons.
Item 4. Purpose of Transaction.
The Reporting Persons have acquired securities of the Issuer for
investment purposes.
Item 5. Interest in Securities of the Issuer.
The following information is based on a total of 27,094,002 shares of
Common Stock outstanding after the completion of the Private Placement.
Calculations with respect to DP IV give effect to the exercise of
presently-exercisable Warrants to purchase 472,293 shares of Common Stock and
calculations with respect to DP IV A give effect to the exercise of
presently-exercisable Warrants to purchase 11,318 shares of Common Stock.
(a)
DP IV
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CUSIP No. 911646 20 6 Page 8 of 44 Pages
DP IV owns 2,833,760 shares of Common Stock, or approximately 10.3% of
the Common Stock outstanding. OPSA IV, as the general partner of DP IV, may
be deemed to beneficially own the shares of Common Stock owned by DP IV.
DP IV A
DP IV A owns 67,906 shares of Common Stock, or approximately 0.3% of
the Common Stock outstanding. OPSA IV, as the general partner of DP IV A,
may be deemed to beneficially own the shares of Common Stock owned by DP IV
A.
(b) The managing members of OPSA IV may be deemed to share the power
to vote or direct the voting of and to dispose or to direct the disposition of
the Common Stock owned by DP IV and DP IV A. Each of the managing members of
OPSA IV disclaims beneficial ownership of all shares of Common Stock other than
the shares of Common Stock he or she owns by virtue of his or her indirect pro
rata interest, as a managing member of OPSA IV, in the Common Stock owned by DP
IV and/or DP IV A.
(c) Not applicable.
(d) Except as described in this statement, no person has the power to
direct the receipt of dividends on, or the proceeds from sales of, the shares of
Common Stock owned by DP IV or DP IV A.
(e) Not applicable.
Item 6. Contracts, Arrangements, Understandings
or Relationships with Respect to
Securities of the Issuer.
Under the terms of the Purchase Agreement, and as further described
therein, the Reporting Persons have agreed not to make any disposition of the
Shares, the Warrants or the shares of Common Stock underlying the Warrants (the
"Warrant Shares") prior to the first anniversary of the closing of the
transactions contemplated by the Purchase Agreement. During the two year period
commencing on such first anniversary date, the Reporting Persons have agreed not
to make any such disposition (other than certain excluded dispositions) without
first giving USB the right to accept an offer to sell such securities to USB.
In addition, the Purchase Agreement, as also further described
therein, provides the Reporting Persons with certain rights regarding
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CUSIP No. 911646 20 6 Page 9 of 44 Pages
the registration of the Shares and the Warrant Shares (and any
shares of Common Stock issued in connection therewith), in the form of "Demand
Registration" rights and "Piggy-back Registration" rights.
Item 7. Material to be Filed as Exhibits.
Exhibit A - Group Agreement (Appears at Page 11)
Exhibit B - Purchase Agreement (Appears at Page 12)
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CUSIP No. 911646 20 6 Page 10 of 44 Pages
Signature
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
Dated: February 4, 1999
DOMAIN PARTNERS IV, L.P.
By: One Palmer Square Associates
IV L.L.C., General Partner
By /s/ Kathleen K. Schoemaker
Managing Member
DP IV ASSOCIATES, L.P.
By: One Palmer Square Associates
IV L.L.C., General Partner
By /s/ Kathleen K. Schoemaker
Managing Member
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CUSIP No. 911646 20 6 Page 11 of 44 Pages
EXHIBIT A
AGREEMENT OF
DOMAIN PARTNERS IV, L.P.
AND
DP IV ASSOCIATES, L.P.
PURSUANT TO RULE 13d-1(k)
The undersigned hereby agree that the Statement on Schedule 13D to
which this Agreement is annexed as Exhibit A is filed on behalf of each of them
in accordance with the provisions of 13d-1(k) under the Securities Exchange Act
of 1934, as amended.
Dated: February 4, 1999
DOMAIN PARTNERS IV, L.P.
By: One Palmer Square Associates
IV L.L.C., General Partner
By /s/ Kathleen K. Schoemaker
Managing Member
DP IV ASSOCIATES, L.P.
By: One Palmer Square Associates
IV L.L.C., General Partner
By /s/ Kathleen K. Schoemaker
Managing Member
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CUSIP No. 911646 20 6 Page 12 of 44 Pages
EXHIBIT B
SECURITIES PURCHASE AGREEMENT
THIS SECURITIES PURCHASE AGREEMENT is made as of the 27th day of
January, 1999, by and among U.S. Bioscience, Inc., a Delaware corporation
("USB"), and the several purchasers listed on Schedule I hereto (such purchasers
being herein referred to individually as a "Purchaser" and collectively as the
"Purchasers").
WHEREAS, the Purchasers desire to purchase from USB, and USB desires
to sell to the Purchasers certain shares of USB's common stock and certain
warrants to purchase USB's common stock, on the terms and subject to the
conditions set forth in this Agreement.
NOW, THEREFORE, in consideration of the covenants and obligations
expressed herein, and intending to be legally bound, the parties agree as
follows:
1. Purchase and Sale of Stock and Warrants.
1.1 Sale and Issuance of Common Stock and Warrants. Subject to
the terms and conditions of this Agreement, each Purchaser agrees to purchase
and USB agrees to sell and issue to each Purchaser, for the amount set forth
opposite the name of such Purchaser in Schedule I hereto under the heading
"Purchase Price" (the "Purchase Price"), (a) the number of shares of USB's
Common Stock, $.01 par value (the "Common Stock"), set forth opposite the name
of such Purchaser in Schedule I hereto under the heading "Shares" (the "Shares")
and (b) a warrant in substantially the form attached hereto as Exhibit A (a
"Warrant") to purchase that number of shares of USB's Common Stock set forth
opposite the name of such Purchaser in Schedule I hereto under the heading
"Warrant Shares" (the "Warrant Shares").
1.2 Closing. The closing for the purchase and sale of the Shares
and the Warrants (the "Closing") shall take place at the offices of USB, One
Tower Bridge, 100 Front Street, West Conshohocken, Pennsylvania 19428, at 2:00
p.m., Philadelphia time, on the business day after the date on which the
conditions set forth in Articles 4 and 5 shall be satisfied or duly waived, or
if USB and the Purchasers mutually agree on a different date, the date upon
which they have mutually agreed (the "Closing Date"). At the Closing, USB shall
issue and deliver to each Purchaser a certificate registered in the name of such
Purchaser representing the Shares being purchased by such Purchaser hereunder
and shall deliver a Warrant to purchase the number of Warrant Shares being
purchased by such Purchaser hereunder, against delivery to USB by such Purchaser
of such Purchaser's Purchase Price, by wire transfer in immediately available
funds to USB's account pursuant to the written wire transfer instructions
previously supplied to the Purchasers.
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CUSIP No. 911646 20 6 Page 13 of 44 Pages
2. Representations, Warranties and Covenants of USB. USB hereby
represents and warrants to the Purchasers that, except as set forth in the
Disclosure Schedules attached hereto and made a part hereof (the "Schedules"):
2.1 Organization and Good Standing. USB is a corporation duly
organized, validly existing and in good standing under the laws of the State of
Delaware and has all requisite corporate power and authority under its
Certificate of Incorporation and Bylaws to own and operate its properties and
assets and to carry on its business as now conducted.
2.2 Authorization. USB has the corporate power and authority to
execute, deliver and perform this Agreement and the Warrants and to issue and
sell the Shares and the Warrant Shares. The execution, delivery and the
performance of this Agreement and the Warrants by USB and the issuance and
delivery of the Shares and the Warrant Shares have been duly authorized by all
necessary corporate action on the part of USB. USB is duly qualified to transact
business and is in good standing in each jurisdiction in which the failure so to
qualify would have a material adverse effect on its business, properties or
financial condition. This Agreement and the Warrants constitute valid and
legally binding obligations of USB, enforceable against USB in accordance with
their respective terms, except as such may be limited by bankruptcy, insolvency
or other similar laws affecting the enforcement of creditors' rights in general
and by general principles of equity.
2.3 Valid Issuance of Shares. The Shares and the Warrant Shares,
when issued, sold and delivered in accordance with the terms hereof and the
terms of the Warrants, respectively, will be duly and validly issued, fully paid
and nonassessable, free and clear of any liens, charges, claims or encumbrances
and, except as provided in this Agreement and the Warrants, will not be subject
to restrictions on transfer arising through USB.
2.4 Government Consents.
(a) Except for any applicable state securities laws, no consent,
approval, order or authorization of, or registration, qualification,
designation, declaration or filing with, any federal, state or local
governmental authority, is required on the part of USB, nor is any waiver,
consent or approval of any third party (other than the listing of the Shares and
Warrant Shares on the American Stock Exchange) required to be obtained by USB,
in connection with USB's valid execution, delivery or performance of this
Agreement and the Warrants.
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CUSIP No. 911646 20 6 Page 14 of 44 Pages
(b) USB shall have made any filings required to be made under
applicable state securities laws in connection with the transactions
contemplated by this Agreement, within the applicable stipulated statutory
period before or after the sale of the Shares and the Warrants hereunder, and
shall have obtained such consents or approvals to issue the Shares and the
Warrants as may be required pursuant to such laws.
2.5 Litigation. There is no action, suit, proceeding or
investigation pending or currently threatened against USB which questions the
validity of this Agreement, the Warrants or the right of USB to enter into it or
to consummate the transactions contemplated hereby. Except as disclosed on
Schedule 2.5 or in the SEC Filings (as defined in Section 2.7), there is no
action, suit, proceeding or investigation pending or currently threatened which,
singly or in the aggregate, if the subject of an unfavorable decision, ruling or
finding, would materially adversely affect the business, properties, operations,
financial condition, income or business prospects of USB and its subsidiaries,
taken as a whole, as presently being conducted. To the knowledge of USB, there
does not exist any basis for any such action, suit, investigation or proceeding.
2.6 Compliance with Other Instruments. The execution, delivery
and performance of this Agreement and the Warrants by USB and the consummation
by USB of the transactions contemplated hereby and thereby will not conflict
with, or result in any violation of, or constitute, with or without the passage
of time and giving of notice, either a default under any provision of its
Certificate of Incorporation or Bylaws or of any instrument, judgment, order,
writ, decree or contract or an event which results in the creation of any lien,
charge or encumbrance upon any assets of USB. USB is not in violation of its
Certificate of Incorporation or Bylaws, or in default in the performance or
observance of any material provision of any material instrument or contract to
which it is a party or by which it is bound. No third party has any pre-emptive
rights, or rights of first refusal or first opportunity or similar rights to
purchase, or to offer to purchase, all or any part of the Shares and the Warrant
Shares.
2.7 Disclosure. USB has furnished to the Purchasers (i) USB's
Annual Report on Form 10-K for the fiscal year ended December 31, 1997 (the
"1997 Annual Report"), as filed with the SEC pursuant to the Securities Exchange
Act of 1934, as amended (the "Exchange Act"); (ii) USB's proxy statement for its
1998 Annual Meeting of Stockholders; (iii) USB's Form 10/A, Amendment No. 2, as
filed with the SEC pursuant to the Exchange Act; (iv) USB's reports on Form 10-Q
for the fiscal quarters ended March 31, 1998, June 30, 1998 and September 30,
1998 (collectively, the "Quarterly Reports"), as filed with the SEC pursuant to
the Exchange Act, and (v) all other reports and registration statements, if any,
as filed by USB with the SEC since December 31, 1997 (the documents referred to
in clauses (i)-(v) above being referred to hereinafter, collectively, as the
"SEC Filings"). As of their respective dates, the SEC Filings (including all
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CUSIP No. 911646 20 6 Page 15 of 44 Pages
documents incorporated by reference therein) did not contain any untrue
statement of a material fact or omit to state a material fact required to be
stated therein or necessary to make the statements therein, in light of the
circumstances under which they were made, not misleading, except, in the case of
any SEC Filing, any statement or omission therein which has been corrected or
otherwise disclosed or updated in a subsequent SEC Filing. Since December 31,
1997, USB has timely filed with the SEC all reports, documents, registration
statements, definitive proxy statements and all other filings required to be
filed with the SEC under the rules and regulations of the SEC, and all such
reports, documents, registration statements, definitive proxy statements and
other filings complied in all material respects with all applicable requirements
of the Securities Act of 1933, as amended (the "1933 Act"), and the Exchange
Act, as applicable. Neither this Agreement nor any of the Schedules hereto
contains any untrue statement of material fact, or omits to state any material
fact necessary in order to make the statements contained therein, in light of
the circumstances under which they were made, not misleading. The audited
consolidated financial statements of USB included or incorporated by reference
in the 1997 Annual Report and the unaudited consolidated financial statements
contained in the Quarterly Reports have been prepared in accordance with United
States generally accepted accounting principles applied on a consistent basis
throughout the periods indicated and with each other, except as may be indicated
therein or in the notes thereto and except that the unaudited financial
statements may not contain all footnotes and adjustments required by United
States generally accepted accounting principles, and fairly present the
financial position of USB and its consolidated subsidiaries as at the dates
thereof and the results of its operations and statements of cash flows for the
periods then ended, subject, in the case of the unaudited interim consolidated
financial statements, to normal year-end adjustments, and recognizing that the
results of operations for interim periods are not necessarily indicative of
USB's operations for any other interim period or full fiscal year.
2.8 Changes. Since December 31, 1997, except as disclosed in the
SEC Filings or in Schedule 2.8, there has not been:
(a) any change in the assets, liabilities, financial condition,
operating results or, to the best of USB's knowledge, prospects of USB from that
reflected in the 1997 Annual Report, except changes in the ordinary course of
business that have not been, in the aggregate, materially adverse (and except
that USB expects to continue to incur substantial operating losses, which may be
material);
(b) any damage, destruction or loss, whether or not covered by
insurance, materially and adversely affecting the business, properties or
financial condition of USB (and except that USB expects to continue to incur
substantial operating losses, which may be material);
(c) any waiver or compromise by USB of a material right or of a
material debt owed to it;
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CUSIP No. 911646 20 6 Page 16 of 44 Pages
(d) any satisfaction or discharge of any lien, claim or
encumbrance or payment of any obligation by USB, except in the ordinary course
of business and which is not material to the business, properties or financial
condition of USB (as such business is presently conducted);
(e) any material change to a material contract or arrangement by
which USB or any of its assets is bound or subject, or any breach by USB or
waiver by USB of any breach of or under any such contract or amendment (or the
occurrence of any event which would, as result of the passage of time, become or
result in such a breach or waiver);
(f) any sale, assignment or transfer to a third party that is not
an Affiliate (as hereafter defined) of any material patents, trademarks,
copyrights, trade secrets or other intangible assets for compensation which is
less than fair value;
(g) any mortgage, pledge, transfer of a security interest in, or
lien, created by USB, with respect to any of its material properties or assets,
except liens for taxes not yet due or payable;
(h) any declaration, setting aside or payment or other
distribution in respect of any of USB's capital stock;
(i) the occurrence of any event or condition of any type that has
materially and adversely affected the business, properties or financial
condition of USB, or the occurrence of any such event or condition known to USB
that will, solely upon the passage of time, materially and adversely affect the
business, properties or financial condition of USB.
For purposes of this Agreement (except as otherwise defined in Section 6.1(b)
hereof) the term "Affiliate" means any individual or entity directly or
indirectly controlling, controlled by or under common control with, a party to
this Agreement. Without limiting the foregoing, the direct or indirect ownership
of 50% or more of the outstanding voting securities of an entity, or the right
to receive 50% or more of the profits or earnings of an entity, shall be deemed
to constitute control.
2.9 American Stock Exchange Listing. The Common Stock is
currently listed and traded on the American Stock Exchange and USB knows of no
reason or set of facts which is likely to result in the termination of such
listing. Nothing in this Section 2.9 shall be interpreted to preclude USB from
listing its Common Stock on any other national securities exchange (including
without limitation the Nasdaq National Market of The Nasdaq Stock Market) in
lieu of the American Stock Exchange. USB shall take all actions reasonably
required in order to have the Shares listed on the American Stock Exchange prior
to the Closing.
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CUSIP No. 911646 20 6 Page 17 of 44 Pages
2.10 Capitalization; Options and Warrants. The authorized capital
stock of USB consists of 5,000,000 shares of Preferred Stock, par value $.005
per share, none of which are outstanding as of the date hereof, and 50,000,000
shares of Common Stock, par value $.01 per share, of which 24,363,199 shares
were issued and outstanding as of December 31, 1998. Except (x) as disclosed in
the SEC Filings, (y) for the Stock Options granted under any Employee Benefit
Plans (as hereinafter defined) and (z) for the transactions contemplated by this
Agreement, (i) no subscription, warrant, option, convertible security or other
right (contingent or other) to purchase or acquire any shares of any class of
capital stock of USB is authorized or outstanding, (ii) there is not any
commitment of USB to issue any shares, warrants, options or other such rights or
to distribute to holders of any class of its capital stock any evidences of
indebtedness or assets, (iii) USB has no obligation (contingent or other) to
purchase, redeem or otherwise acquire any shares of its capital stock or any
interest therein or to pay any dividend or make any other distribution in
respect thereof and (iv) since December 31, 1998, USB has not granted any
options (except for stock options granted under USB's employee benefit plans, as
defined in Rule 405 of Regulation C under the 1933 Act ("Employee Benefit
Plans")) warrants, rights (including conversion or preemptive rights), or
similar right, to any person or entity to purchase or acquire any rights with
respect to any shares of capital stock of USB, including the Shares and the
Warrant Shares. The total number of shares of Common Stock of USB issued from
December 31, 1998 through the date of this Agreement is 44,075. Except as
disclosed in the SEC Filings, there are no outstanding rights to cause USB to
register the securities held by any person or entity under the Securities Act of
1933 except for any such rights with respect to securities issuable upon the
exercise of options granted under any USB Employee Benefit Plans.
2.11 Subsidiaries. The only subsidiaries of USB are USB Pharma
B.V., incorporated in The Netherlands ("USB BV"), USB Pharma Limited,
incorporated in the United Kingdom ("USB UK"), USB Resources, Inc., a Delaware
corporation, and USB Technology, Inc., a Delaware corporation. Each of USB's
subsidiaries has been duly incorporated under the laws of its respective
jurisdiction of incorporation. USB BV and USB UK are the only operating
subsidiaries of USB, and each of such subsidiaries has full corporate power and
authority to own or lease its properties and conduct its business as presently
conducted, and is duly qualified or licensed to transact business in all
jurisdictions in which the character of the property owned or leased or the
nature of the business transacted by it requires such qualification (except
where the failure to be so qualified would not have a material adverse effect on
the business, properties, operations, financial condition, income or business
prospects of USB and its subsidiaries, taken as a whole, as presently being
conducted). USB owns 100% of the shares of each of its subsidiaries, free any
clear of any charges or encumbrances, and there are no outstanding options,
warrants, or rights to purchase any securities of any subsidiaries.
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CUSIP No. 911646 20 6 Page 18 of 44 Pages
2.12 Principal Products. Except as set forth in Schedule 2.12,
there has been no material adverse change in the status or commercial
development of Hexalen(R), NeuTrexin(R) or Ethyol(R) as set forth under the
heading "Principal Products" on pages 3-10 of the 1997 Annual Report.
3. Representations, Warranties and Covenants of the Purchasers. Each
Purchaser hereby represents and warrants, severally and not jointly, and solely
with respect to itself, to USB that:
3.1 Authorization. This Agreement constitutes such Purchaser's
valid and legally binding obligation, enforceable against such Purchaser, in
accordance with its terms, except as such may be limited by bankruptcy,
insolvency or other similar laws affecting the enforcement of creditors' rights
in general or by general principles of equity. Such Purchaser represents that it
has the partnership power and authority to execute and deliver this Agreement
and perform its obligations hereunder.
3.2 Government Consents.
No consent, approval, order or authorization of, or registration,
qualification, designation, declaration or filing with, any federal, state or
local governmental authority is required on the part of such Purchaser in
connection with such Purchaser's valid execution, delivery or performance of its
obligations under this Agreement.
3.3 Purchase Entirely for Own Account. The Shares, the Warrants
and the Warrant Shares are being (or will be, as the case may be) acquired for
such Purchaser's own account, not as a nominee or agent, and not with a view to
the resale or distribution of any part thereof, and such Purchaser has no
present intention of selling, granting any participation in, or otherwise
distributing the same except in compliance with the registration requirements of
the 1933 Act (unless an exception is available). Such Purchaser does not have
any contract, undertaking, agreement or arrangement with any person to sell,
transfer or grant participation to such person or to any third person, with
respect to any of the Shares, the Warrants or the Warrant Shares.
3.4 Disclosure of Information. Such Purchaser has had an
opportunity to ask questions and receive answers from USB regarding the terms
and conditions of the offering and sale of the Shares, the Warrants and the
Warrant Shares. The foregoing, however, does not limit or modify the
representations and warranties of USB in Section 2 hereof or the right of such
Purchaser to rely thereon.
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CUSIP No. 911646 20 6 Page 19 of 44 Pages
3.5 Investment Experience. Such Purchaser acknowledges that it
can bear the economic risk of its investment and has such knowledge and
experience in financial or business matters that it is capable of evaluating the
merits and risks of the investment in the Shares, the Warrants and the Warrant
Shares. Such Purchaser also represents it has not been organized for the purpose
of acquiring the Shares, the Warrants or the Warrant Shares.
3.6 Accredited Investor. Such Purchaser is an "accredited
investor" within the meaning of SEC Rule 501 of Regulation D, as presently in
effect.
3.7 Restricted Securities. Such Purchaser understands that the
Shares, the Warrants and the Warrant Shares are "restricted securities" under
the federal securities laws and that under such laws and applicable regulations,
such Shares, Warrants and Warrant Shares may be resold without registration
under the 1933 Act only in certain limited circumstances. In this connection,
such Purchaser represents that it is familiar with SEC Rule 144 promulgated
under the 1933 Act ("Rule 144"), as presently in effect, and understands the
resale limitations imposed thereby and by the Act.
3.8 Restriction on Offers and Sales of Shares; First Offer Right
of USB.
(a) Such Purchaser shall not make any disposition of the Shares,
the Warrants or the Warrant Shares, prior to the first anniversary of the
Closing Date.
(b) During the two-year period commencing on the first
anniversary of the Closing Date (the "First Offer Period"), such Purchaser shall
not make any disposition of any Shares, Warrants or Warrant Shares, whether
through broker-dealers who may act as agent or acquire the Shares as principal,
or otherwise, without first giving USB the right to accept an offer to sell such
Shares to USB as provided in this Section 3.8 provided, however, that nothing
herein shall restrict the ability of any Purchaser to distribute all or any
portion of the Shares, the Warrants or the Warrant Shares to one or more of such
Purchaser's partners or Affiliates as provided in Section 3.8(f)(i) below. In
addition, Shares that are transfered pursuant to the exception set forth in
Section 3.8(f)(i) below shall thereafter not be subject to the restrictions set
forth in this Section 3.8(b). If at any time during the First Offer Period any
Purchaser wishes to make a disposition of any Shares, Warrants or Warrant Shares
other than to its Affiliates or partners, it shall submit an offer to sell such
Shares, Warrants or Warrant Shares to USB (the "Offer"), by telephonic
communication with USB's President and Chief Executive Officer or any Executive
Vice President (such telephonic communication to be confirmed in writing by
notice pursuant to Section 7.6), disclosing the number of Shares, Warrants or
Warrant Shares proposed to be sold or transferred and the price at which such
Shares, Warrants or Warrant Shares are offered to USB. As soon as practicable
after receipt of the Offer, but in no event later than three business days after
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CUSIP No. 911646 20 6 Page 20 of 44 Pages
such Purchaser makes the Offer, USB shall have the option to accept the Offer,
in whole but not in part, on the terms offered. In the event that USB does not
accept the Offer, such Shares, Warrants or Warrant Shares may be sold by such
Purchaser at any time within 90 days after the expiration of the Offer for the
price (or a higher price) at which such Shares, Warrants or Warrant Shares were
offered to USB.
(c) During the First Offer Period, any Shares, Warrants or
Warrant Shares not sold in accordance with the applicable terms and within the
applicable time periods provided in Section 3.8(b) shall continue to be subject
to the requirements of a first offer pursuant to Section 3.8(b).
(d) If USB accepts an Offer under Section 3.8(b), the closing of
such purchase shall occur within ten business days after acceptance of the Offer
by USB. Upon such acceptance, USB and such Purchaser shall be legally obligated
to consummate the purchase contemplated thereby.
(e) The provisions of Sections 3.8(b) and (c) shall lapse and
cease to have any effect at such time as such Purchaser owns less than 100,000
Shares.
(f) The provisions of this Section 3.8 shall not apply to:
(i) any transfer by such Purchaser of Shares, Warrants or Warrant
Shares to an Affiliate or limited partner of Purchaser, provided that the
transferee is bound by all of the obligations of such Purchaser under this
Agreement with respect to the Shares, Warrants and Warrant Shares and under this
Agreement and the Warrants with respect to the Warrants and the Warrant Shares,
other than the provisions of Section 3.8(b), it being understood that any of
such Shares, Warrants or Warrant Shares so transferred will not be subject to
said Section 3.8(b);
(ii) any pledge of the Shares, Warrants or Warrant Shares by such
Purchaser as part of a pledge of assets by such Purchaser solely in connection
with a financing by such Purchaser and/or any Affiliates of such Purchaser, or
any asset-backed financing or similar financing vehicle;
(iii) any transfer to the successor to the business of such
Purchaser in a merger, acquisition or change of control of such Purchaser in
which such Purchaser is not the surviving entity, provided that the successor is
not an Affiliate of such Purchaser prior to such merger, acquisition or change
of control; or
(iv) any offer or sale of Registrable Securities pursuant to
Section 6.2(a) or (b).
(g) In the event of a Change of Control (as hereinafter defined),
the provisions of this Section 3.8 shall no longer be effective. For purposes of
this Agreement, a "Change of Control"shall occur upon the consummation of (i)
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CUSIP No. 911646 20 6 Page 21 of 44 Pages
any transaction that results in a person having beneficial ownership of 30% or
more of the voting securities of USB or (ii) a sale of all or substantially all
of the assets of USB.
3.9 Further Limitations on Disposition. Without in any way
limiting the provisions set forth in Section 3.8, such Purchaser further shall
not make any disposition of all or any portion of the Shares, Warrants or
Warrant Shares unless and until:
(a) There is then in effect a registration statement under the
1933 Act covering such proposed disposition and such disposition is made in
accordance with such registration statement; or
(b) Such Purchaser shall have satisfied the following conditions:
(i) such Purchaser shall have notified USB of the proposed disposition and (ii)
if reasonably requested by USB, such Purchaser shall have furnished USB with an
opinion of counsel, reasonably satisfactory to USB, that such disposition will
not require registration of such Shares under the 1933 Act.
3.10 Legends. It is understood that the certificates evidencing
the Shares and the Warrant Shares may bear the following legends:
(a) "These securities have not been registered under the 1933
Act. They may not be sold or offered for sale in the absence of a registration
statement in effect with respect to the securities under such Act or an opinion
of counsel reasonably satisfactory to USB that such registration is not
required."
(b) "These securities may not be sold, assigned, transferred, or
in any manner disposed of, except in compliance with the terms of a Securities
Purchase Agreement between USB and Purchaser, dated as of January 27, 1999. Such
agreement imposes certain restrictions on transfer of the securities represented
by this certificate. The Secretary of USB will upon written request furnish a
copy of such agreement to the holder hereof without charge."
(c) Any legend required by any applicable state securities laws.
USB shall use its best efforts to cause its transfer agent to take all necessary
actions in order to permit the Purchasers to make good delivery of all Shares
sold in accordance with the terms of this Agreement, including, without
limitation, the timely removal of the legends from any Shares validly
transferred in accordance with the terms of this Agreement.
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CUSIP No. 911646 20 6 Page 22 of 44 Pages
4. Conditions of Purchaser's Obligations.
4.1 Conditions of Purchaser's Obligations at the Closing. The
obligations of the Purchasers to USB at the Closing are subject to the
fulfillment on or before the Closing of each of the following conditions:
(a) Representations and Warranties. The representations and
warranties of USB contained in Section 2 hereof shall be true and correct on and
as of the Closing Date with the same effect as though such representations and
warranties had been made on and as of the Closing Date except for
representations and warranties that speak as of a specific date or time other
than the Closing Date (which need only be true and correct in all material
respects as of such date and time).
(b) Performance. USB shall have performed and complied with all
agreements, obligations and conditions contained in this Agreement that are
required to be performed or complied with by it on or before the Closing.
(c) Compliance Certificate. The President and Chief Executive
Officer or any Executive Vice President of USB shall deliver to the Purchasers
at the Closing a certificate, in the form attached as Exhibit B hereto,
certifying that the conditions specified in Sections 4.1(a) and (b) hereof have
been fulfilled.
(d) Governmental Approvals. Any required governmental approvals
described in Section 2.4(b) shall have been obtained by USB.
(e) Listing of Shares. The Shares and the Warrant Shares shall
have been approved, subject to official notice of issuance, for listing by the
American Stock Exchange.
(f) Tender of Shares. USB shall have issued and tendered for
delivery to each Purchaser a certificate representing the Shares and a Warrant
representing the right to acquire Warrant Shares (each as set forth in Schedule
I), subject only to delivery of the Purchase Price by such Purchaser in
accordance with Section 1.1.
(g) Legal Opinion. The Purchasers shall have received the opinion
of Morgan, Lewis & Bockius LLP in the form attached hereto as Exhibit C.
5. Conditions of USB's Obligations.
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CUSIP No. 911646 20 6 Page 23 of 44 Pages
5.1 Conditions of USB's Obligations at the Closing. The
obligations of USB to the Purchasers at the Closing are subject to the
fulfillment on or before the Closing of each of the following conditions:
(a) Representations and Warranties. The representations and
warranties of the Purchasers contained in Section 3 hereof shall be true and
correct on and as of the Closing Date with the same effect as though such
representations and warranties had been made on and as of the Closing Date.
(b) Performance. The Purchasers shall have performed and complied
with all agreements, obligations and conditions contained in this Agreement that
are required to be performed or complied with by them on or before the Closing.
(c) Compliance Certificate. The General Partner of each of the
Purchasers shall deliver to USB at the Closing a certificate, in the form
attached as Exhibit D hereto, certifying that the conditions specified in
Sections 5.1(a) and (b) hereof have been fulfilled.
(d) Listing of Shares. The Shares and the Warrant Shares shall
have been approved, subject to official notice of issuance, for listing by the
American Stock Exchange.
(e) Payment of Purchase Price. The Purchasers shall have
delivered to USB the Purchase Price in accordance with Section 1.1, subject only
to delivery by USB of the certificates representing the Shares and of the
Warrants.
6. Registration Rights.
6.1 Definitions. For purposes of this Section 6:
(a) The terms "register," "registered," and "registration" refer
to a registration effected by preparing and filing a registration statement or
similar document in compliance with the 1933 Act, and the declaration or
ordering of effectiveness of such registration statement or document;
(b) The term "Registrable Securities" means (1) the Shares, (2)
the Warrant Shares and (3) any shares of Common Stock of USB issued as (or
issuable upon the conversion or exercise of any warrant, right or other security
which is issued as) a dividend or other distribution with respect to, or in
exchange for or in replacement of, such Shares or Warrant Shares, excluding in
all cases, however, any Registrable Securities sold by a person in a transaction
in which its rights under this Section 6 are not assigned. As to any particular
Registrable Securities, once issued such
<PAGE>
CUSIP No. 911646 20 6 Page 24 of 44 Pages
securities shall cease to be Registrable Securities when (i) a registration
statement with respect to the sale of such securities shall have become
effective under the 1933 Act and such securities shall have been disposed of in
accordance with such registration statement, (ii) such securities shall have
been distributed pursuant to Rule 144, (iii) such securities are transferred to
or become beneficially owned by USB or any "affiliate" (as defined in Rule 144)
thereof (other than any bank or insurance company acting in the ordinary course
of its business), or (iv) such securities shall have ceased to be outstanding;
(c) The number of shares of "Registrable Securities then
outstanding" shall be determined by the number of shares of Common Stock
outstanding and the number of shares of Common Stock issuable pursuant to then
exercisable or convertible securities, which are, in each case, Registrable
Securities;
(d) The term "Managing Underwriter" means one or more nationally
recognized firms of investment bankers.
6.2 Registration.
(a) Demand Registrations.
(i) Requests for Registration. At any time after the first
anniversary of the Closing Date until the sixth anniversary of the Closing Date,
Purchasers holding at least 50% of the Registrable Securities then outstanding,
subject to adjustment for stock splits, stock dividends, stock combinations and
transactions with similar effect, may demand registration (a "Demand
Registration") under the 1933 Act of all or any portion of the Registrable
Securities owned by such Purchasers. In order to accomplish such demand, the
Purchasers shall send written notice of the demand to USB, and such notice shall
specify the number of Registrable Securities sought to be registered. USB shall
only be required to effect two Demand Registrations.
(ii) Procedure. Within 10 days after receipt of such a demand,
USB will give written notice of such requested registration to all other
Purchasers holding Registrable Securities and will include in such registration,
subject to the allocation provisions below, all other Registrable Securities
with respect to which USB has received written requests for inclusion within 15
days after USB's mailing of such notice, plus any securities of USB that USB
chooses to include on its own behalf or pursuant to "piggy-back" registration
rights granted by USB to others.
(iii) Priority on Demand Registrations. If a Demand Registration
is underwritten and the Managing Underwriter advises USB in writing that in its
opinion the number of Registrable Securities requested to be included exceeds
the number that can be sold in such offering, at a price reasonably related to
fair value, USB will include in such Demand Registration first, the Registrable
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CUSIP No. 911646 20 6 Page 25 of 44 Pages
Securities requested to be included in such Demand Registration by the
Purchasers and the other holders requesting to have shares included in the
registration, pro rata on the basis of the number of Common Stock owned; and
second, any securities that USB desires to include on its own behalf. A
registration shall not be considered to be a Demand Registration under Section
6.2(a)(i), and USB shall pay the Registration Expenses of such registration, if
(1) as a result of the foregoing allocation, the Purchasers are not able to
register and sell in the Demand Registration at least 75% of the Registrable
Securities sought to be included in the Demand Registration by the Purchasers;
(2) the gross proceeds of the securities included in the registration on behalf
of USB constitute at least 20% of the total gross proceeds of the Demand
Registration; or (3) the registration statement requested by a Purchasers does
not become effective for any reason.
(iv) Selection of Underwriters. If any Demand Registration is
underwritten, the selection of the Managing Underwriter and the other decisions
regarding the underwriting arrangements for the offering will be made by USB and
the Purchasers initiating such registration.
(v) Restrictions on Demand Registrations. USB will not be
obligated to effect any Demand Registration within six months after the
effective date of a previous registration of securities of USB in an
underwritten offering.
(b) Piggy-back Registration. If (but without any obligation to do
so) USB proposes to register (including for this purpose a registration effected
by USB for any stockholders other than a Purchaser) any of its Common Stock
under the 1933 Act in connection with the public offering of such securities
solely for cash (other than a registration relating solely to the sale of
securities to participants in a USB Employee Benefit Plan or a registration on
Form S-4 relating to a business combination involving USB, or any similar
successor form), USB shall, not later than three business days after the date
such registration is proposed, give the Purchasers written notice of such
registration. Upon the written request of the Purchasers given within 20 days
after such notice by USB in accordance with Section 7.6 hereof, USB shall,
subject to the provisions of Section 6.9 hereof cause to be included in such
registration and any underwriting involved therein all of the Registrable
Securities that the Purchasers have requested to be registered. Notwithstanding
the foregoing, the rights of the Purchasers under this Section 6.2(b): (i) shall
not be applicable in respect of any registration by USB which shall become
effective prior to the first anniversary of the Closing Date and covers only
securities offered by USB; and (ii) shall terminate on the sixth anniversary of
the Closing Date.
6.3 Obligations of USB. With respect to any registration of any
Registrable Securities pursuant to Section 6.2, USB shall, as expeditiously as
reasonably possible:
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CUSIP No. 911646 20 6 Page 26 of 44 Pages
(a) Prepare and file with the SEC a registration statement with
respect to such Registrable Securities and use its best efforts to cause such
registration statement to become effective. As far in advance as practical
before filing such registration statement or any supplement or amendment thereto
(including any document incorporated therein by reference) USB will furnish to
the Purchasers and their counsel copies of reasonably complete drafts of all
such documents proposed to be filed (including exhibits), and the Purchasers and
their counsel shall have the opportunity to comment on any information that is
contained therein or omitted therefrom and USB will make the changes reasonably
requested by the Purchasers and their counsel with respect to such information
prior to filing any such registration statement.
(b) Prepare and file with the SEC such amendments and supplements
to the registration statement and the prospectus used in connection with the
registration as may be necessary to comply with the provisions of the 1933 Act
with respect to the disposition of all securities covered by the registration,
including at Purchaser's request, any amendments or supplements necessary to
reflect any information regarding such Purchaser or its plan of distribution,
and once effective, use its best efforts to maintain the effectiveness of the
registration statement until the earlier of (i) the date on which all of the
Shares included under such registration statement cease being Registrable
Securities and (ii) the 90th day after the date of effectiveness of the
registration statement.
(c) Furnish to the Purchasers such numbers of copies of a
prospectus, including a preliminary prospectus, as then amended or supplemented,
in conformity with the requirements of the 1933 Act, and such other documents as
they may reasonably request in order to facilitate the disposition of
Registrable Securities owned by the Purchasers.
(d) Use its best efforts to register and qualify the securities
covered by the Demand Registration under such other securities or Blue Sky laws
of such jurisdictions as shall be reasonably requested by the Purchasers,
provided that USB shall not be required in connection therewith or as a
condition thereto to qualify to do business or to file a general consent to
service of process in any such states or jurisdictions.
(e) Notify the Purchasers at any time when a prospectus relating
thereto is required to be delivered under the 1933 Act of the happening of any
event as a result of which the prospectus included in such registration
statement, as then in effect, includes an untrue statement of a material fact or
omits to state a material fact required to be stated therein or necessary to
make the statements therein not misleading in the light of the circumstances
then existing, and, at the request of the Purchasers, as promptly as practicable
prepare and furnish the Purchasers a reasonable number of copies of a prospectus
included in an effective post-effective amendment or the supplemented prospectus
correcting such misstatement or omission.
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CUSIP No. 911646 20 6 Page 27 of 44 Pages
(f) Furnish, at the request of the Purchasers, (i) an opinion of
the counsel representing USB for the purposes of registration, in form and
substance as is customarily given to underwriters in an underwritten public
offering, addressed to the underwriters, if any, and to the Purchasers and (ii)
a comfort letter and subsequent bring-down letter, from the independent
certified public accountants of USB, in form and substance as is customarily
given by independent certified public accountants to underwriters in an
underwritten public offering, addressed to the underwriters, if any. If the
Registrable Securities are being sold in an underwritten offering pursuant to
Section 6.2(b) hereof, such opinion shall be furnished and dated as of the
closing of the sale to the underwriters, such comfort letter shall be furnished
and dated as of the date of the underwriting agreement and the bring-down letter
shall be furnished and dated as of the closing of the sale to the underwriters.
If the Registrable Securities are not being sold in an underwritten offering,
such opinion shall be furnished and dated as of the date that the registration
statement with respect to such securities becomes effective.
(g) In the event of any underwritten public offering of any
Registrable Securities pursuant to Section 6.2(b), enter into and perform its
obligations under an underwriting agreement, in usual and customary form, with
the Managing Underwriter of such offering, provided, however, that the
Purchasers shall also enter into and perform their obligations under any such
agreement.
6.4 Furnish Information. It shall be a condition precedent to
the obligations of USB to take any action pursuant to this Section 6 that the
Purchasers meet the following conditions:
(a) The Purchasers shall furnish such information regarding
themselves, the Registrable Securities held by them, and the intended method of
disposition of such securities as shall be required by applicable federal or
state securities laws to effect the registration of the Registrable Securities.
(b) All information specifically with respect to the Purchasers
furnished to USB by or on behalf of the Purchasers in writing for use in
connection with the preparation of any registration statement relating to such
Registrable Securities shall be true and correct in all material respects and
shall not omit any material fact necessary to make such information, in light of
the circumstances under which it was made, not misleading.
(c) The Purchasers will review carefully any registration
statement relating to such Registrable Securities and each amendment or
supplement thereto upon receipt thereof from USB and will promptly advise USB in
writing if: (i) the name and address of the Purchasers (if required to be
disclosed) is not properly set forth; or (ii) the Purchasers have entered into
any material arrangement with a broker-dealer for the sale of Registrable
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CUSIP No. 911646 20 6 Page 28 of 44 Pages
Securities through a cross or block trade, special offering, exchange
distribution or secondary distribution or a purchase by a broker-dealer required
to be disclosed in the registration statement that is not disclosed therein.
(d) The Purchasers shall distribute in connection with the
offering and sale of the Registrable Securities the prospectus or other offering
material permitted by the 1933 Act and prepared by USB, and only such materials.
(e) The Purchasers will comply with the provisions of the
Exchange Act and the regulations thereunder.
(f) To assist USB in qualifying the Registrable Securities for
sale under applicable state securities laws, the Purchasers will advise USB of
each jurisdiction in which they intend to offer or sell any or all Registrable
Securities, and agree not to offer or sell any Registrable Securities in any
jurisdiction where the Registrable Securities are not registered or exempt from
registration.
(g) The Purchasers will inform USB in writing of any and all
sales, or other transfers or dispositions of any Registrable Securities or of
any interest therein within 15 calendar days following each such disposition,
such notification to include the date of the disposition and the number of
Registrable Securities which were disposed of.
(h) In the event of any underwritten public offering of any
Registrable Securities pursuant to Section 6.2(b), the Purchasers shall enter
into and perform their obligations under an underwriting agreement, in the form
agreed upon by USB and the underwriters selected by it.
6.5 Expenses of Registration. Except as otherwise provided in
this Section 6.5, USB shall bear the expenses incurred in connection with the
Demand Registration and any amendment or supplement thereof, including: all
registration, filing, qualification, printers' and accounting fees and the fees
and disbursements of counsel for USB. The expenses borne by USB pursuant to this
Section 6.5 shall exclude (i) underwriter discounts and commisions, broker fees
and commissions and transfer taxes, if any, in respect of Registrable
Securities, which shall be payable by the Purchasers; (ii) all out-of-pocket
expenses of the Purchasers' brokers or dealers; and (iii) all fees and
disbursements of counsel for the Purchasers or any such brokers or dealers.
6.6 Company Suspension.
(a) The Purchasers shall, upon receipt of any written notice from
USB of the happening of any event of the kind described in Section 6.3(e),
forthwith discontinue their disposition of Registrable Securities pursuant to
such registration statement (it being understood that Purchaser's right to
dispose of Registrable Securities by other means in accordance with applicable
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CUSIP No. 911646 20 6 Page 29 of 44 Pages
laws shall not be restricted hereby) until the Purchasers receive the copies of
the supplemented or amended prospectus and, if so directed by USB, will deliver
to USB (at USB's expense) all copies, other than permanent file copies, then in
the Purchasers' possession of the prospectus relating to such Registrable
Securities current at the time of receipt of such notice.
(b) The Purchasers shall upon receipt of any notice from USB that
in the good faith judgment of USB the filing or making of offers and sales
pursuant to the registration statement would require the public disclosure of
material information, the disclosure of which would not otherwise be required at
that time and either compiling such information would require unreasonable
effort in the circumstances or disclosure thereof would have a material adverse
effect on USB, USB shall have the right to suspend such sales or postpone such
filing for a period which shall not exceed 60 days (provided that no such notice
may be given beginning when the Purchasers notify USB that marketing efforts
have begun by an underwriter on behalf of the Purchasers in connection with an
offering thereof and ending when such offering is completed or abandoned);
provided, however, that USB may not use the right provided by this paragraph
until 120 days have elapsed from the end of the most recent suspension or
postponement period initiated by USB and provided, further, however, that
immediately following disclosure of such information or withdrawal or
abandonment of the transaction requiring suspension or postponement USB will
make such filing or take such steps as are necessary to permit such offers and
sales, as the case may be. Any suspension under this Section 6.6(b) will extend,
for an amount of time equal to such suspension, the termination date of any
registration rights, or obligations to keep a registration effective, otherwise
provided in this Agreement.
6.7 Indemnification. In the event any Registrable Securities are
included in a registration statement under this Section 6:
(a) To the extent permitted by law, USB will indemnify and hold
harmless each Purchaser, and each of its partners, officers and directors, any
underwriter (as defined in the 1933 Act) for the Purchasers and each person, if
any, who controls such Purchaser or any such underwriter within the meaning of
the 1933 Act or the Exchange Act (collectively, the "Indemnified Purchaser
Parties"), against any losses, claims, damages, or liabilities (joint or
several) to which they may become subject under the 1933 Act, the Exchange Act
or other federal or state law or otherwise, insofar as such losses, claims,
damages, or liabilities (or actions in respect thereof) arise out of or are
based upon a claim by a third party, that is not an Indemnified Purchaser Party,
or an Affiliate of any Indemnified Purchaser Party, alleging any of the
following statements, omissions or violations (collectively, "Indemnified
Violations"): (i) any untrue statement or alleged untrue statement of a material
fact contained in such registration statement, including any preliminary
prospectus or final prospectus contained therein, or any amendments or
supplements thereto, or any document incident to such registration (such as a
Blue Sky qualification or compliance); (ii) the
<PAGE>
CUSIP No. 911646 20 6 Page 30 of 44 Pages
omission or alleged omission to state therein a material fact required to be
stated therein, or necessary to make the statements therein not misleading; or
(iii) any Indemnified Violation or alleged Indemnified Violation under the 1933
Act, the Exchange Act, any state securities law or any rule or regulation
promulgated under the 1933 Act, the Exchange Act or any state securities law,
and USB will reimburse each of the USB Indemnified Parties for any legal and
other expenses reasonably incurred in connection with defending any such
Indemnified Violations; provided, however, that the indemnity agreement
contained in this Section 6.7(a) shall not apply to amounts paid in settlement
of any such loss, claim, damage, liability, or action if such settlement is
effected without the consent of USB (which consent shall not be unreasonably
withheld), nor shall USB be liable in any such case for any such loss, claim,
damage, liability or action to the extent that it arises out of or is based upon
an Indemnified Violation which occurs in reliance upon and in conformity with
written information furnished expressly for use in connection with such
registration by any of the Indemnified Purchaser Parties.
(b) To the extent permitted by law, the Purchasers will indemnify
and hold harmless USB, each of its officers and directors, each person, if any,
who controls USB within the meaning of the 1933 Act, any underwriter, any other
person selling securities in such registration statement and any controlling
person of any such underwriter or other person (collectively, the "Indemnified
USB Parties"), against any losses, claims, damages, or liabilities (joint or
several) to which they may become subject, under the 1933 Act, the Exchange Act
or other federal or state law, insofar as such losses, claims, damages, or
liabilities (or actions in respect thereof) arise out of or are based upon a
claim by a third party, that is not an Indemnified USB Party, or an Affiliate of
any Indemnified USB Party, arising out of or based upon written information
furnished by any of the Indemnified Purchaser Parties expressly for use in
connection with such registration, and the Purchasers will reimburse each of the
Indemnified USB Parties for any legal and other expenses reasonably incurred in
connection with defending any such loss, claim, damage, liability or action;
provided, however, that the indemnity agreement contained in this Section 6.7(b)
shall not apply to amounts paid in settlement of any such loss, claim, damage,
liability or action if such settlement is effected without the consent of the
Purchasers (which consent will not be unreasonably withheld); and provided
further, however, that in no event shall any indemnity under this Section 6.7(b)
exceed the Purchasers' proceeds from the offering.
(c) Promptly after receipt by an indemnified party under this
Section 6.7 of notice of the commencement of any action (including any
governmental action), such indemnified party will, if a claim in respect thereof
is to be made against any indemnifying party under this Section 6.7, deliver to
the indemnifying party a written notice of the commencement thereof, generally
summarizing the claims, and the indemnifying party shall have the right to
participate in, and, to the extent the indemnifying party so desires, jointly
with any other indemnifying party similarly noticed, to assume the defense
thereof with counsel mutually satisfactory to the parties; provided, however,
<PAGE>
CUSIP No. 911646 20 6 Page 31 of 44 Pages
that an indemnified party shall have the right to retain its own counsel, with
the fees and expenses to be paid by the indemnifying party, if representation of
such indemnified party by the counsel retained by the indemnifying party would
be inappropriate due to actual or potential differing interests between such
indemnified party and any other party represented by such counsel in such
proceeding. The failure to deliver written notice to the indemnifying party
within a reasonable time of the commencement of any such action, if prejudicial
to its ability to defend such action, shall relieve such indemnifying party of
any liability to the indemnified party under this Section 6.7, but the omission
so to deliver written notice to the indemnifying party will not relieve it of
any liability that it may have to any indemnified party otherwise than under
this Section 6.7.
(d) The obligations of USB and the Purchasers under this Section
6.7 shall survive the completion of any offering of Registrable Securities in a
registration statement under this Section 6, and otherwise.
6.8 Reports Under the Exchange Act. With a view to making
available to the Purchasers the benefits of Rule 144 and any other rule or
regulation of the SEC that may at any time permit the Purchasers to sell
securities of USB to the public without registration, USB agrees to:
(a) make and keep public information available, as those terms
are understood and defined in Rule 144;
(b) file with the SEC in a timely manner all reports and other
documents required of USB under the 1933 Act and the Exchange Act; and
(c) furnish to a Purchaser, so long as such Purchaser owns any
Registrable Securities, promptly upon request (i) a written statement by USB
that it has complied with the reporting requirements of Rule 144, the 1933 Act
and the Exchange Act, (ii) a copy of the most recent annual or quarterly report
of USB and such other reports and documents so filed by USB, and (iii) such
other information as may be reasonably requested in availing such Purchaser of
any rule or regulation of the SEC which permits the selling of any such
securities without registration.
6.9 Underwriting Requirements. In connection with any proposed
registration as to which the Purchasers have a right to notice under Section
6.2(b):
(a) USB shall not be required to include in such registration any
of the Registrable Securities unless the Purchasers accept the terms of the
underwriting that are agreed upon between USB and the Managing Underwriter
selected by it; and
<PAGE>
CUSIP No. 911646 20 6 Page 32 of 44 Pages
(b) if the Managing Underwriter for the offering advises USB in
writing that the number of Registrable Securities requested to be included will
adversely affect the success of the offering, USB shall include in such offering
only the quantity of Registrable Securities, if any, as shall be determined as
set forth below:
(i) first, USB shall include in such underwriting all of the
securities USB proposes to sell; and
(ii) then, USB shall include the number of Registrable
Securities and USB securities of other holders that the Managing Underwriter
advises will not adversely affect the success of the offering, allocated, pro
rata, among the Purchasers and the other holders requesting registration, based
upon the number of shares of Common Stock each such person shall have requested
USB to include in the offering.
6.10 Transfer or Assignment of Registration Rights The rights to
cause USB to register Registrable Securities and the obligations of USB pursuant
to this Section 6 may be transferred or assigned by a Purchaser to any partner
or Affiliate of such Purchaser. In addition, such Purchaser shall have the right
to transfer or assign its rights under Section 6.2 (a) and (b) (relating to the
Demand Registration and piggy-back registration) in connection with a transfer
of all of the Shares and Warrants, or otherwise upon the reasonable consent of
USB, provided that: (i) such transfer is permitted under this Agreement; and
(ii) the transferee enters into a written agreement whereby the transferee
agrees to be bound by the remaining rights and obligations of such Purchaser set
forth in Sections 6 and 7 hereof (the "Purchaser Obligations"). If, in
accordance with the preceding provisions of this Section 6.10, such Purchaser
shall transfer or assign its registration rights to a single holder (the "New
Holder") that is a partnership, trust or similar pass-through entity, such
registration rights may be further transferred to any partner, beneficiary or
related person of the New Holder in connection with a distribution of
Registrable Securities by the New Holder to such partner, beneficiary or related
person; provided that, within a reasonable time after such transfer, USB is
furnished with a written notice of the name and address of such partner,
beneficiary or related person and the Registrable Securities with respect to
which such registration rights are being transferred; and provided, further,
that such transfer shall be effective only if it is registered under all
applicable securities laws or is exempt from registration thereunder and the
transferee agrees in writing to be bound by the Purchaser Obligations.
6.11 Amendment of Registration Rights. Any provision of this
Section 6 may be amended or the observance thereof may be waived either
generally or in a particular instance and either retroactively or
prospectively), only with the written consent of USB and the holders of a
majority of the Registrable Securities then outstanding. Any amendment or waiver
effected in accordance with this Section 6.11 shall be binding upon each holder
of any Registrable Securities,
<PAGE>
CUSIP No. 911646 20 6 Page 33 of 44 Pages
each future holder of Registrable Securities, the Purchasers and USB. Nothing
herein shall prevent a holder of Registrable Securities from waiving its
individual rights.
6.12 Change of Control. In the event of a Change of Control,
the restriction on exercise of registration rights prior to the first
anniversary of the Closing Date set forth in Section 6.2(a) and Section 6.2(b)
shall no longer be effective.
7. Miscellaneous.
7.1 Survival of Warranties. The warranties and representations
of USB and the Purchasers contained in or made pursuant to this Agreement shall
survive until the third anniversary of the Closing Date and shall in no way be
affected by any investigation of the subject matter thereof made by or on behalf
of the Purchasers or USB.
7.2 Successors and Assigns. The terms and conditions of this
Agreement shall inure to the benefit of and be binding upon the respective
successors and assigns of the parties. Nothing in this Agreement, express or
implied, is intended to confer upon any party other than the parties hereto or
their respective successors and assigns any rights, remedies, obligations, or
liabilities under or by reason of this Agreement, except as expressly provided
in this Agreement.
7.3 Governing Law. This Agreement shall be governed by and
construed under the laws of the State of Delaware as applied to agreements among
Delaware residents entered into and to be performed entirely within Delaware.
7.4 Counterparts. This Agreement shall become binding when any
one or more counterparts hereof, individually or taken together, shall bear the
signatures of USB and the Purchaser. This Agreement may be executed in two or
more counterparts, each of which shall be deemed an original as against any
party whose signature appears thereon, but all of which together shall
constitute one and the same instrument. A facsimile transmission of the signed
Agreement shall be legal and binding on both parties.
7.5 Titles and Subtitles. The titles and subtitles used in
this Agreement are used for convenience only and are not to be considered in
construing or interpreting this Agreement.
7.6 Notices. Unless otherwise provided, any notice required or
permitted under this Agreement shall be sent by certified mail or courier
service, charges pre-paid, or by facsimile transmission, to the address or
facsimile number specified below:
<PAGE>
CUSIP No. 911646 20 6 Page 34 of 44 Pages
If to USB: One Tower Bridge
100 Front Street
West Conshohocken, PA 19428
Attention: Chief Executive Officer
Fax No.: 610-832-4595
with a copy to: General Counsel
Fax No.: 610-832-4595
If to any Purchaser, to the address appearing on Schedule I hereto
with a copy to: Reboul, MacMurray, Hewitt, Maynard & Kristol
45 Rockefeller Plaza
New York, NY 10111
Attention: Mark M. Sugino, Esquire
Fax No.: 212-841-5725
or to such other address or facsimile number as the person may specify in a
notice duly given to the sender as provided herein. A notice will be deemed to
have been given as of the date that is five days after it is deposited in the
United States mail or the date it is delivered by a courier service or, in the
case of facsimile transmission or personal communication, when received.
7.7 Finders' Fee. Each party agrees to indemnify and to hold
harmless the other party from any liability for any commission or compensation
in the nature of a finders' fee (and the costs and expenses of defending against
such liability or asserted liability) for which the indemnifying party or any of
its officers, partners, employees, or representatives is responsible.
7.8 Market Holdback. The Purchasers shall not sell, transfer
or otherwise dispose of (other than to a transferee who agrees to be similarly
bound) any Registrable Securities during any specified holdback period of up to
90 days following, and 14 days preceding, the filing date of a registration
statement filed by USB under the 1933 Act for an offering by USB of Common Stock
or other securities if, (i) the holdback is requested in writing by the Managing
Underwriter of the offering; (ii) the same restrictions are agreed to by all of
the executive officers and directors of USB; and (iii) the Purchasers receive
written notice of the holdback in advance of the restricted period, specifying
the dates during which the restrictions will apply. Notwithstanding the
foregoing, the holdback restrictions described in this Section 7.8 shall not
apply to sales made by any person pursuant to and in accordance with the
underwritten offering described in such registration statement filed by USB. If
any specified holdback period hereunder occurs during any period in which the
Purchasers are permitted to sell Shares pursuant to Section 3.8, the time period
within which the
<PAGE>
CUSIP No. 911646 20 6 Page 35 of 44 Pages
Purchasers must sell its Shares under Section 3.8 will be tolled until the
completion of the holdback period, and the period of Purchaser's registration
rights pursuant to this Agreement shall be extended by the number of days of the
holdback period.
7.9 Expenses. Each party shall pay all costs and expenses that
it incurs with respect to the negotiation, execution, delivery and performance
of this Agreement provided, however, that USB shall pay the costs and expenses
of one counsel to the Purchasers up to a maximum of $5,000. If any action at law
or in equity is necessary to enforce or interpret the terms of this Agreement,
the prevailing party shall be entitled to reasonable attorney's fees, costs and
necessary disbursements in addition to any other relief to which such party may
be entitled.
7.10 Publicity. Neither party, nor any of their respective
Affiliates, shall issue or cause the publication of any press release or other
public announcement with respect to this Agreement or any of the other
transactions contemplated hereby without the prior consultation of the other
party, except as may be required law or by any listing agreement with a national
securities exchange. The parties shall cooperate in determining the format, date
and time of day of the announcement of the execution and terms of this
Agreement, giving consideration to the requirements of all applicable laws and
regulations, and each party will obtain the prior approval by the other party of
any press release to be issued relating to the announcement of the execution of
this Agreement or the Closing hereunder, which prior approval shall not be
unreasonably withheld or delayed. This Section 7.10 shall not apply to the
extent that any disclosure is of information in the public domain other than
through the fault of the disclosing party in violation hereof.
7.11 Amendments and Waivers. This Agreement may not be
amended, supplemented or otherwise modified except by an instrument in writing
signed by both parties that specifically refers to this Agreement. Either party
hereto may, only by an instrument in writing, waive compliance by the other
party hereto with any term or provision of this Agreement on the part of such
other party to be performed or complied with. The waiver by a party hereto of a
breach of any term or provision of this Agreement shall not be construed as a
waiver of any subsequent breach. Any amendment or waiver effected in accordance
with this Section 7.11 shall be binding upon each party and its permitted
assigns.
7.12 Severability. If one or more provisions of this Agreement
are held to be unenforceable under applicable law, such provision shall be
excluded from this Agreement and the balance of the Agreement shall be
interpreted as if such provision were so excluded and shall be enforceable in
accordance with its terms.
<PAGE>
CUSIP No. 911646 20 6 Page 36 of 44 Pages
IN WITNESS WHEREOF, the parties, through their duly authorized
officers, have duly executed this Agreement as of the date first above written.
U.S. BIOSCIENCE, INC.
By: /s/ C. Boyd Clarke
Title: President & CEO
DOMAIN PARTNERS IV, L.P.
By: One Palmer Square Associates IV, L.L.C.,
its General Partner
By: /s/ Kathleen K. Schoemaker
Managing Member
DP IV ASSOCIATES, L.P.
By: One Palmer Square Associates IV, L.L.C.,
its General Partner
By: /s/ Kathleen K. Schoemaker
Managing Member
PROQUEST INVESTMENTS, L.P.
By: Proquest Associates, LLC
By: /s/ Jay Moorin
Managing Member
<PAGE>
CUSIP No. 911646 20 6 Page 37 of 44 Pages
<TABLE>
<CAPTION>
SCHEDULE I
<S> <C> <C> <C>
Name of Partner Purchase Price Shares Warrant Shares
- --------------- -------------- ------ --------------
Domain Partners IV, L.P. $17,578,760.35 2,361,467 472,293
One Palmer Square
Princeton, NJ 08542
Attention: Kathleen Schoemaker
Fax No.: 609-683-9787
DP IV ASSOCIATES, L.P. $421,241.07 56,588 11,318
One Palmer Square
Princeton, NJ 08542
Attention: Kathleen Schoemaker
Fax No.: 609-683-9787
PROQUEST INVESTMENTS, L.P. $2,000,001.81 268,673 53,735
One Palmer Square
Princeton, NJ 08542
Attention: Jeremy Goldberg
Fax No.: 609-430-1127
Total: $20,000,003.23 2,686,728 537,346
============== ========= =========
</TABLE>
<PAGE>
CUSIP No. 911646 20 6 Page 38 of 44 Pages
EXHIBIT A TO PURCHASE AGREEMENT
Form of Warrant
---------------
THIS WARRANT HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933.
IT MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE
ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THE WARRANT
UNDER SUCH ACT OR AN OPINION OF COUNSEL SATISFACTORY TO U.S.
BIOSCIENCE, INC. THAT SUCH REGISTRATION IS NOT REQUIRED.
THIS WARRANT MAY NOT BE SOLD, ASSIGNED, TRANSFERRED, OR IN ANY MANNER
DISPOSED OF, EXCEPT IN COMPLIANCE WITH THE TERMS OF A SECURITIES
PURCHASE AGREEMENT, DATED AS OF JANUARY 27, 1999, AMONG U.S. BIOSCIENCE,
INC., THE HOLDER AND THE OTHER PARTIES THERETO. SUCH AGREEMENT
IMPOSES CERTAIN RESTRICTIONS ON TRANSFER OF THIS WARRANT.
U.S. BIOSCIENCE, INC.
WARRANT FOR THE PURCHASE OF SHARES OF COMMON STOCK
, 1999
--------
No. Shares
----- --------
This Warrant is issued pursuant to Section 1 of the Securities
Purchase Agreement, dated as of January 27, 1999 (the "Securities Purchase
Agreement"), among the Company, the Holder and the other parties thereto. The
shares issuable upon exercise of this Warrant have certain rights, and are
subject to certain restrictions, set forth in the Securities Purchase Agreement.
THIS CERTIFIES that, for value received, U.S. Bioscience,
Inc., a Delaware corporation (the "Company"), upon the surrender of this Warrant
to the Company at the address specified herein, at any time during the Exercise
Period (as defined below) will upon receipt of the Exercise Price (as defined
below), sell and deliver to (the "Holder") up to the number of
----------------
duly authorized, validly issued and fully paid and nonassessable shares of
common stock of the Company, par value $.01 per share, set forth above. The term
"Common Stock" shall mean
<PAGE>
CUSIP No. 911646 20 6 Page 39 of 44 Pages
the aforementioned common stock of the Company together with any other equity
securities that may be issued by the Company in connection therewith or in
substitution therefor, as provided herein. The "Exercise Period" shall begin on
, 1999 [original issuance date] and shall end on , 2002 [third
- -------- --------
anniversary of original issuance date]. During the Exercise Period, the Holder
may purchase such number of shares of Common Stock at a purchase price per share
equal to Eleven Dollars and 16.6 Cents ($11.166) (the "Exercise Price").
The number of shares of Common Stock to be received upon the
exercise of this Warrant is subject to adjustment from time to time as
hereinafter set forth. The shares of Common Stock deliverable upon such
exercise, as adjusted from time to time, are hereinafter sometimes referred to
as "Warrant Shares".
Section A. Exercise of Warrant. This Warrant may be exercised
in whole or in part, at any time or from time to time, during the Exercise
Period by presentation and surrender hereof to the Company at its principal
office at One Tower Bridge, 100 Front Street, Suite 400, West Conshohocken,
Pennsylvania 19428 (or at such other address as the Company or its agent may
hereafter designate in writing to the Holder), or at the office of its warrant
agent, with the Purchase Form contained herein duly executed and accompanied by
wire transfer of immediately available funds, cash or a certified or official
bank check drawn to the order of "U.S. Bioscience, Inc." in the amount of the
Exercise Price multiplied by the number of Warrant Shares specified in such
form. If this Warrant should be exercised in part only, the Company shall, upon
surrender of this Warrant, promptly execute and deliver a new Warrant evidencing
the rights of the Holder to purchase the balance of the Warrant Shares
purchasable hereunder. Upon receipt by the Company during the Exercise Period of
this Warrant and such Purchase Form, in proper form for exercise, together with
proper payment of the Exercise Price, at such office, or by the warrant agent of
the Company at its office, the Holder shall be deemed to be the holder of record
of the number of Warrant Shares specified in such form; provided, however, that
if the date of such receipt by the Company or its agent is a date on which the
stock transfer books of the Company are closed, such person shall be deemed to
become the record holder of such shares on, and such certificate shall be dated,
the next succeeding business day on which the stock transfer books of the
Company are open. The Company shall pay any and all documentary, stamp or
similar issue or transfer taxes payable in respect of the issue or delivery of
such Warrant Shares. Any new or substitute Warrant issued under this Section 1
or any other provision of this Warrant shall be dated the date of this Warrant.
Upon exercise of this Warrant, the Company or its warrant agent shall promptly
cause to be issued and shall promptly deliver upon written order of the Holder
of this Warrant, and in such name or names as such Holder may designate, a
certificate or certificates for the Warrant Shares.
Section B. Warrant Register. This Warrant will be registered
in a register (the "Warrant Register") to be maintained by the Company or its
agent at its principal office in the name of the record holder to whom it has
been distributed. The Company may deem and treat the
<PAGE>
CUSIP No. 911646 20 6 Page 40 of 44 Pages
registered holder of this Warrant as the absolute owner hereof (notwithstanding
any notation of ownership or other writing hereon made by anyone), for the
purpose of any exercise hereof or any distribution to the Holder and for all
other purposes, and the Company shall not be affected by any notice to the
contrary.
Section C. Reservation of Shares. The Company hereby agrees
that at all times there shall be reserved for issuance and delivery upon
exercise of this Warrant all shares of its Common Stock or other shares of
capital stock of the Company from time to time issuable upon exercise of this
Warrant. All such shares shall be duly authorized and, when issued upon such
exercise, shall be validly issued, fully paid and nonassessable, free and clear
of all liens, security interests, charges and other encumbrances or restrictions
on sale and free and clear of all preemptive rights, except as set forth in the
Securities Purchase Agreement.
Section D. Transfer of Warrant. This Warrant may not be
transferred by the Holder, except as set forth in the Securities Purchase
Agreement. Subject to the foregoing, this Warrant shall inure to the benefit of
the successors to the Holder. This Warrant and all rights hereunder, in whole or
in part, is registrable at the office or agency of the Company referred to above
by the Holder hereof in person or by his duly authorized attorney, upon
surrender of this Warrant properly endorsed.
Section E. Certain Matters. The Holder has certain
registration rights with respect to the Warrant Shares as set forth in the
Securities Purchase Agreement. The Warrant Shares are listed on the American
Stock Exchange, as set forth in the Securities Purchase Agreement. This Warrant
and the Warrant Shares are subject to certain restrictions, as set forth in the
Securities Purchase Agreement.
Section F. Lost, Mutilated or Missing Warrant. Upon receipt by
the Company of evidence reasonably satisfactory to it of the loss, theft,
destruction or mutilation of this Warrant, and (in the case of loss, theft or
destruction) of reasonably satisfactory indemnification, and upon surrender and
cancellation of this Warrant, if mutilated, the Company, at its expense, shall
execute and deliver a new Warrant of like tenor and date.
Section G. Rights of the Holder. The Holder shall not, by
virtue hereof, be entitled to any rights or subject to any obligation or
liability of a stockholder in the Company, either at law or equity, and the
rights of the Holder are limited to those expressed in this Warrant.
Section H. Adjustments. The number of shares purchasable
hereunder are subject to adjustment from time to time as follows:
<PAGE>
CUSIP No. 911646 20 6 Page 41 of 44 Pages
(1) Stock Dividend, Split or Subdivision of Shares. If
the number of shares of Common Stock outstanding at any time after the date
hereof is increased by a stock dividend payable to all holders of Common Stock
in shares of Common Stock or by a subdivision or split-up of shares of Common
Stock, then, following the record date fixed for the determination of holders of
Common Stock entitled to receive such stock dividend, subdivision or split-up,
the number of shares of Common Stock issuable on exercise of this Warrant shall
be increased in proportion to such increase in outstanding shares.
(2) Combination of Shares. If, at any time after the
date hereof, the number of shares of Common Stock outstanding is decreased by a
combination or consolidation of the outstanding shares of Common Stock, by
reclassification, reverse stock split or otherwise, then, following the record
date for such combination, the number of shares of Common Stock issuable on
exercise of each Warrant shall be decreased in proportion to such decrease in
outstanding shares.
(3) Calculations. All calculations under this Section 8
shall be made to the nearest share.
(4) Merger and Consolidation. If at any time there is a
capital reorganization or reclassification of shares of Common Stock, or a
merger or consolidation of the Company with or into another corporation where
the Company is not the surviving corporation, or the sale of all or
substantially all of the Company's properties and assets to any other person,
then as part of such reorganization, reclassification, merger, consolidation or
sale, lawful provision shall be made so that the Holder shall thereafter be
entitled to receive upon exercise of its rights to purchase Common Stock, the
number of shares of stock, cash, property or shares of the successor corporation
resulting from such merger or consolidation, to which a holder of Common Stock,
deliverable upon exercise of the rights to purchase Common Stock hereunder,
would have been entitled in such reorganization, reclassification, merger,
consolidation or sale if the right to purchase such Common Stock hereunder had
been exercised immediately prior to such reorganization, reclassification,
merger, consolidation or sale. In any such event, appropriate adjustment shall
be made in the application of the provisions of this Warrant with respect to the
rights and interests of the Holder after such reorganization, reclassification,
merger, consolidation or sale so that the provisions of this Warrant (including
the number of shares of Common Stock purchasable pursuant to the terms and
conditions of this Warrant) shall be applicable after that event as near as
reasonably may be, in relation to any shares deliverable upon the exercise of
the Holder's rights to purchase Common Stock pursuant to this Warrant.
(5) Certificate as to Adjustments. Upon the occurrence
of each adjustment or readjustment pursuant to this Section 8, the Company, at
its own expense, shall promptly compute such adjustment or readjustment in
accordance with the terms hereof and furnish to the Holder a certificate setting
forth such adjustment or readjustment and showing in detail the
<PAGE>
CUSIP No. 911646 20 6 Page 42 of 44 Pages
facts upon which such adjustment or readjustment is based. The Company shall,
upon the written request at any time of the Holder, furnish or cause to be
furnished to the Holder a like certificate setting forth such adjustments and
readjustments and the number of shares and the amount, if any of other property
that at the time would be received upon the exercise of this Warrant.
Section I. No Fractional Shares. No fractional shares of the
Company's Common Stock will be issued in connection with any purchase hereunder,
and any fractional share shall be rounded to the nearest share.
<PAGE>
CUSIP No. 911646 20 6 Page 43 of 44 Pages
Section J. Notices of Certain Events. In the event:
(1) the Company authorizes the issuance to all holders of
its Common Stock of rights or warrants to subscribe for or purchase shares of
its Common Stock or of any other subscription rights or warrants; or
(2) of any capital reorganization or reclassification of
shares of Common Stock, or of any merger or consolidation of the Company with or
into another corporation where the Company is not the surviving corporation, or
of the sale of all or substantially all of the Company's properties and assets
to any other person; or
(3) of the voluntary or involuntary dissolution,
liquidation or winding-up of the Company; or
(4) any other actions would require an adjustment under
Section 8 hereof;
then the Company will cause to be mailed to the Holder, at least ten days before
the applicable record or effective date hereinafter specified, a notice stating
(i) the date as of which the holders of Common Stock of record entitled to
receive any such rights or warrants are to be determined, or (ii) the date on
which any such reorganization, reclassification, merger, consolidation, sale,
dissolution, liquidation or winding-up is expected to become effective, and the
date as of which it is expected that holders of Common Stock of record will be
entitled to exchange their shares of Common Stock for securities or other
property, if any, deliverable upon such reorganization, reclassification,
merger, consolidation, sale, dissolution, liquidation or winding-up.
Section K. Successors. All the provisions of this Warrant by
or for the benefit of the Company shall bind and inure to the benefit of its
successors and assigns.
Section L. Amendments. The terms and provisions of this
Warrant may not be modified or amended, or any provisions hereof waived,
temporarily or permanently, except by written consent of the Company and the
Holder hereof.
Section M. Notices. Unless otherwise provided in this Warrant,
all notices, requests, consents and other communications hereunder shall be in
writing, shall be sent by U.S. Mail or a nationally recognized overnight express
courier postage prepaid, and shall be deemed given one day after being so sent,
or if delivered by hand shall be deemed given on the date of such delivery to
such party, or if sent to such party (in the case of a Holder) at its address in
the Warrant Register that will be maintained by the Company or its agent in
accordance with Section 2 hereof or (in the case of the Company) at its address
set forth in Section 1 hereof, Attention: Chief Financial Officer, or to such
other address as is designated by written notice, similarly given to each other
party hereto.
<PAGE>
CUSIP No. 911646 20 6 Page 44 of 44 Pages
Section N. Governing Law. This Warrant shall be governed by
and construed under the laws of the State of Delaware as applied to agreements
among Delaware residents entered into and to be performed entirely within
Delaware.
IN WITNESS WHEREOF, the Company has duly caused this Warrant
to be duly executed as of the date first set forth above.
U.S. BIOSCIENCE, INC.
By:
Title:
