NEUROGEN CORP
10-Q, 1997-05-15
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
                       SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549


                       --------------------------------
                                   FORM 10-Q

    [X]         QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934
                 For the quarterly period ended March 31, 1997

                                       OR

    [ ]        TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                         Commission File Number 0-18311


                              NEUROGEN CORPORATION
             (Exact name of registrant as specified in its charter)

                Delaware                           22-2845714
        (State or other jurisdiction of         (I.R.S. Employer
        incorporation or organization)         Identification No.)

      35 Northeast Industrial Road
        Branford, Connecticut                          06405
(Address of principal executive offices)            (Zip Code)

                                 (203) 488-8201
              (Registrant's telephone number, including area code)

  Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.

                    Yes     X         No
                         -------         -



    As of May 15, 1997, the registrant had 14,338,838 shares of Common Stock
outstanding.
<PAGE>
 
                              NEUROGEN CORPORATION

                                     INDEX


<TABLE>
<CAPTION>
                                                                             Page
                                                                            Number
                                                                            ------

                         Part I - Financial Information
 
<S>        <C>                                                                <C>
Item 1.    Financial Statements...........................................      1
                                                                              
           Balance Sheets at March 31, 1997 and                               
           December 31, 1996..............................................    1,2
           Statements of Operations for the three-month periods  ended        
           March 31, 1997 and 1996........................................      3
           Statements of Cash Flows for the three-month periods ended         
           March 31, 1997 and 1996........................................      4
           Notes to Financial Statements..................................      5
 
Item 2.    Management's Discussion and Analysis of Financial Condition and
           Results of Operations..........................................    6-10

<CAPTION> 
                          Part II - Other Information
<S>        <C>                                                                <C>
Item 1.    Legal Proceedings..............................................    11
                                                                              
Item 2.    Changes in Securities..........................................    11
                                                                              
Item 3.    Defaults upon Senior Securities................................    11
                                                                              
Item 4.    Submission of Matters to a Vote of Security Holders............    11
                                                                              
Item 5.    Other Information..............................................    11
                                                                              
Item 6.    Exhibits and Reports on Form 8-K...............................    11
                                                                              
Signature.................................................................    13
                                                                              
Exhibit Index.............................................................    14-16
</TABLE>


                                       i
<PAGE>
 
                        Part I - Financial Information

Item 1 - Financial Statements

                             Neurogen Corporation
                                Balance Sheets
                                (in thousands)



                                                        
                               March 31,                December 31,
                                 1997                       1996     
                              -----------               -----------
                              (Unaudited) 
                              


             Assets
Current assets:
 Cash and cash equivalents    $  73,305                 $  62,823
 Marketable securities           20,470                    32,314
 Receivables from corporate
  partners                          634                       460
 Other current assets               887                     1,132
                              ---------                 --------- 

   Total current assets          95,296                    96,729

Property, plant & equipment:
 Land and land improvements         523                       523
 Building and building            8,679                     8,679
  improvements                                                   
 Leasehold improvements           4,022                     4,005
 Equipment                        6,594                     5,903
 Furniture                          325                       311
 Construction in progress         1,260                       440 
                              ---------                 --------- 
                                 21,403                    19,861
Less accumulated 
 depreciation and
 amortization                     3,524                     3,136
                              ---------                 --------- 

   Net property, plant and
    equipment                    17,879                    16,725
Other assets, net                   400                       415
                              ---------                 --------- 
                              $ 113,575                 $ 113,869
                              =========                 ========= 

See accompanying notes to financial statements.

                                       1

<PAGE>
 
                             Neurogen Corporation
                                Balance Sheets
                     (in thousands, except per share data)



                                                        
                                           March 31,                December 31,
                                             1997                      1996     
                                          -----------               -----------
                                          (Unaudited) 
                                        
  Liabilities and Stockholders' Equity                                   
Current Liabilities:                    
 Accounts payable and accrued expenses    $   1,917                 $   3,010
 Unearned revenue from corporate
   partners                                   1,695                     4,100
 Current portion of mortgage payable            187                       181
                                          ---------                 --------- 
                                        
   Total current liabilities                  3,799                     7,291
                                        
Mortgage payable, excluding current 
 portion                                        230                       279
Other compensation                               54                        54
                                          ---------                 --------- 
     Total liabilities                        4,083                     7,624

                                        
Stockholders' Equity:                   
 Preferred stock, par value $.025 per share.
  Authorized 2,000 shares; none issued           -                         -
 Common stock, par value $.025 per share.
  Authorized 30,000 shares; issued and
   outstanding 14,330 shares at March 31,
   1997 and 14,252 shares at December 31,
   1996                                         358                       356
Additional paid-in capital                  108,935                   108,491
Retained earnings (deficit)                     331                    (2,519)
Unrealized loss on marketable securities       (132)                      (83)
                                          ---------                 --------- 

   Total stockholders' equity               109,492                   106,245
                                          ---------                 --------- 

                                          $ 113,575                 $ 113,869
                                          =========                 ========= 

See accompanying notes to financial statements.

                                       2
<PAGE>
                              Neurogen Corporation
                            Statements of Operations
                      (In thousands, except per share data)

                                         Three Months      Three Months
                                             Ended             Ended
                                           March 31, 1997   March 31, 1996
                                          (Unaudited)       (Unaudited)
                                          -----------       -----------

Operating revenues:
  License fees                           $       3,000     $       3,000
  Research and Development                       3,979             3,503
                                         --------------    --------------
      Total operating revenues                   6,979             6,503

Operating expenses:
  Research and development                       4,369             3,310
  General and administrative                       955               748
                                         --------------    --------------
    Total operating expenses                     5,324             4,058

                                         --------------    --------------
      Total operating income                     1,655             2,445

Other income (expense):
  Investment income                              1,241             1,249
  Interest expense                                 (11)              (14)
                                         --------------    --------------
    Total other income, net                      1,230             1,235
                                         --------------    --------------

Income before provision for income taxes         2,885             3,680
Provision for income taxes                          35                70
                                         ==============    ==============
Net income                               $       2,850     $       3,610
                                         ==============    ==============

Earnings per share:                      $        0.19     $        0.23
                                         ==============    ==============

Shares used in calculation of
  earnings per share:                           15,366            15,547
                                         ==============    ==============

See accompanying notes to financial statements.

                                       3
<PAGE>
                              Neurogen Corporation
                            Statements of Cash Flows
                                 (In thousands)

<TABLE> 
<CAPTION> 
                                                         Three Months        Three Months
                                                        Ended March 31,     Ended March 31,
                                                             1997                1996
                                                          (Unaudited)        (Unaudited)
                                                        ----------------    ---------------
<S>                                                     <C>                 <C> 
Cash flows from operating activities:
  Net income                                            $         2,850     $        3,610
  Adjustments to reconcile net income to
   net cash used in operating activities:
    Depreciation and amortization expense                           394                217
  Changes in operating assets and liabilities:
    Decrease in accounts payable and accrued expenses            (1,093)              (965)
    Decrease in unearned revenue from corporate partner          (2,405)            (2,605)
    Decrease in other current assets                                245                312
    Increase in receivable from corporate partners                 (174)              (903)
    Decrease in other assets, net                                     9                 40
                                                        ----------------    ---------------

       Net cash used in operating
         activities                                                (174)              (294)

Cash flows from investing activities:
    Purchase of plant and equipment                              (1,542)              (678)
    Purchases of marketable securities                              (10)            (3,070)
    Maturities and sales of marketable securities                11,805              9,442
                                                        ----------------    ---------------

      Net cash provided by investing activities                  10,253              5,694

Cash flows from financing activities:
  Exercise of employee stock options                                446                683
  Principal payments under mortgage payable                         (43)               (38)
                                                        -----------------------------------

    Net cash provided by financing
      activities                                                    403                645
                                                        ----------------    ---------------

     Net increase in cash and cash equivalents                   10,482              6,045

Cash and cash equivalents at beginning of period                 62,823             26,005
                                                        ----------------    ---------------

Cash and cash equivalents at end of period              $        73,305     $       32,050
                                                        ================    ===============
</TABLE> 

See accompanying notes to financial statements.

                                       4
<PAGE>
 
                              NEUROGEN CORPORATION
                         NOTES TO FINANCIAL STATEMENTS
                                 MARCH 31, 1997
                                  (UNAUDITED)



(1)  Basis of Presentation and Summary of Significant Accounting Policies
     ---------------------------------------------------------------------

       The unaudited financial statements have been prepared  from the books and
     records of Neurogen Corporation (the "Company") in accordance with
     generally accepted accounting principles for interim financial information
     pursuant to Rule 10-01 of Regulation S-X.  Accordingly, they do not include
     all of the information and footnotes required by generally accepted
     accounting principles for complete financial statements.  In the opinion of
     management, all adjustments (consisting of normal recurring accruals)
     considered necessary for a fair presentation have been included.  Interim
     results are not necessarily indicative of the results that may be expected
     for the fiscal year.

(3)  Adoption of New Accounting Pronouncements
     -----------------------------------------

       In February 1997, the Financial Accounting Standards Board issued
     Statement No. 128, Earnings per Share, which is required to be adopted on
     December 31, 1997.  At that time, the Company will be required to change
     the method currently used to compute earnings per share and to restate all
     prior periods.  Under the new requirements for calculating primary earnings
     per share, the dilutive effect of stock options will be excluded.  The
     impact is expected to result in an increase in primary earnings per share
     for the first quarter ended March 31, 1997 and March 31, 1996 of $.01 and
     $.03 per share, respectively.  The impact of Statement 128 on the
     calculation of fully diluted earnings per share for these quarters is not
     expected to be material.

(4)  Reclassifications
     -----------------

     Certain reclassifications have been made to the 1996 financial statements
     in order to conform to the 1997 presentation.
<PAGE>
 
ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF
         FINANCIAL CONDITION AND RESULTS OF OPERATIONS

       Since its inception in September 1987, Neurogen has been engaged in the
     discovery and development of drugs. The Company has not derived any revenue
     from product sales and, excluding the effect of one-time license fees
     received in 1996 from Schering-Plough and American Home Products and from
     Schering-Plough and Pfizer in 1995, expects to incur significant losses in
     most years prior to deriving any such product revenues. Revenues to date
     have come from three collaborative research agreements entered into with
     Pfizer, one collaboration with Schering-Plough, one license agreement with
     American Home Products and from interest income.

     RESULTS OF OPERATIONS
 
       Results of operations may vary from period to period depending on
     numerous factors, including the timing of income earned under existing or
     future strategic alliances, joint ventures or financings, if any, the
     progress of the Company's research and development projects, technological
     advances and determinations as to the commercial potential of proposed
     products. Neurogen expects research and development costs to increase
     significantly over the next several years as its drug development programs
     progress. In addition, general and administrative expenses necessary to
     support the expanded research and development activities are expected to
     increase for the foreseeable future.

       The Company's operating revenues increased to $7.0 million for the three
     months ended March 31, 1997 from $6.5 million for the same period in 1996.
     Research and development revenues increased $0.5 million, or 14 percent, to
     $4.0 million due to an increase in research funding pursuant to a December
     1996 amendment to the 1992 and 1994 Pfizer Agreements (as defined below)
     and an increase in the reimbursement of the Company's expense of developing
     its obesity drug candidate, NGD 95-1 pursuant to a cost sharing arrangement
     under the 1995 Pfizer Agreement (as defined below).

       Research and development expenses increased 32 percent to $4.4 million
     for the three-month period ended March 31, 1997 as compared to the same
     period in 1996 due primarily to an increase in research and development
     personnel, an increase in clinical development costs and an expansion of
     Neurogen's AIDD (Accelerated Intelligent Drug Design) program. Research and
     development costs represented 82 percent of total operating expenses for
     the first quarter of 1997 and 1996.

       General and administrative expenses increased 28 percent to $1.0 for the
     three-month period ended March 31, 1997 as compared to the same period in
     1996. This increase is due primarily to an increase in administrative and
     technical activities and to support the Company's expanded research
     programs.
<PAGE>
 
       Other income consisting primarily of interest income, and gains and
     losses from marketable securities remained flat for the three-month period
     ended March 31, 1997 as compared to the same period in 1996.

       The Company recognized net income of $2.9 million for the three months
     ended March 31, 1997 as compared with a net income of $3.6 million for the
     same period in 1996.  The decrease in net earnings is primarily due to the
     increase in research and development and general and administrative
     expenses, partially offset by an increase in total revenues, all as noted
     above.

     LIQUIDITY AND CAPITAL RESOURCES
 
       At March 31, 1997 and December 31, 1996, cash, cash equivalents and
     marketable securities were in the aggregate $93.8 million and $95.1 million
     respectively.  While the Company's aggregate level of cash, cash
     equivalents and marketable securities did not change significantly during
     the first quarter of 1997, these levels have fluctuated significantly in
     the past and are expected to do so in the future as a result of the factors
     described below.

       Neurogen's cash requirements to date have been met by the proceeds of its
     equity financing activities, amounts received pursuant to collaborative
     arrangements and interest earned on invested funds. The Company's financing
     activities include three private placement offerings of its common stock
     prior to its initial public offering, underwritten public offerings of the
     Company's common stock in 1989, 1991 and 1995, and the private sale of
     common stock to Pfizer in connection with entering into the Pfizer
     Agreements and to American Home Products in the American Home Products
     Agreement (as defined below). Total funding received from these equity
     financing activities was approximately $105.6 million. The Company's
     expenditures have been primarily to fund research and development and
     general and administrative expenses and to construct and equip its research
     and development facilities.

       In the first quarter of 1992, the Company entered into its first
     collaborative agreement with Pfizer (the "1992 Pfizer Agreement") pursuant
     to which Pfizer made a $13.8 million equity investment in the Company.
     Under this agreement, the Company received $4.6 million in each year from
     1992 through 1996. Neurogen could also receive milestone payments of up to
     $12.5 million if certain development and regulatory objectives are achieved
     regarding its products subject to the collaboration. In return, Pfizer
     received the exclusive rights to manufacture and market collaboration
     anxiolytics and cognition enhancers that act through the family of
     receptors which interact with the neuro-transmitter gamma-aminobutyric
     acid, or GABA, and for which it will pay Neurogen royalties based upon net
     sales levels, if any, for such products. As of March 31, 1997, Pfizer had
     provided $24.3 million of research funding to the Company pursuant to the
     1992 Pfizer Agreement, in addition to its $13.8 million equity investment
     in 1992.

       Neurogen and Pfizer entered into their second collaborative agreement
     (the "1994 Pfizer Agreement") in July 1994, pursuant to which Pfizer made
     an additional $9.9 million equity investment in the Company. Under this
     agreement, the Company is scheduled to receive
<PAGE>
 
     approximately $7.4 million during the three-year period which commenced
     July 1, 1994, to fund Neurogen's sleep disorder program. Neurogen could
     also receive milestone payments of up to $3.3 million if certain
     development and regulatory objectives are achieved regarding its products
     subject to the collaboration. As part of this second collaboration, Pfizer
     received the exclusive rights to manufacture and market GABA-based sleep
     disorder products for which it will pay Neurogen royalties depending upon
     net sales levels, if any. As of March 31, 1997, Pfizer had provided $7.4
     million (including $0.6 million of unearned revenues) of research funding
     to the Company pursuant to the 1994 Pfizer Agreement, in addition to its
     $9.9 million equity investment in 1994.

       In December 1996, Neurogen and Pfizer extended the research programs
     under the 1992 Pfizer Agreement and 1994 Pfizer Agreement through December
     1998. Pursuant to the extension agreement, Neurogen expects to receive $5.3
     million in each of 1997 and 1998 for research funding of the Company's 
     GABA-based anxiety, cognition enhancement and sleep disorders programs.

       Under both the 1992 Pfizer Agreement and the 1994 Pfizer Agreement, in
     addition to making the equity investments and  the research and milestone
     payments noted above, Pfizer is responsible for funding the cost of all
     clinical development and the manufacturing and marketing, if any, of drugs
     developed from the collaborations.

       Neurogen and Pfizer entered into their third collaborative agreement (the
     "1995 Pfizer Agreement") in November 1995, pursuant to which Pfizer made an
     additional $16.5 million equity investment in the Company bringing Pfizer's
     ownership of the Company's common stock up to 21 percent and paid a $3.5
     million license fee. The Company is scheduled to receive approximately $7.2
     million during the three-year period which commenced November 1, 1995, to
     fund Neurogen's neuropeptide Y (NPY) eating disorders program and may
     receive up to an additional $2.4 million per year for a fourth and fifth
     year should Pfizer exercise its option to extend the research program under
     the collaboration. Neurogen could also receive milestone payments of up to
     approximately $28 million if certain development and regulatory objectives
     are achieved regarding its products subject to the collaboration. As part
     of this third collaboration, Pfizer received the exclusive worldwide rights
     to manufacture and market NPY-based collaboration compounds, subject to
     certain rights retained by Neurogen. Pursuant to the 1995 Pfizer Agreement,
     Neurogen will fund a minority share of early stage development costs and
     has retained the right to manufacture any collaboration products in NAFTA
     countries and has retained a profit sharing option with respect to product
     sales in NAFTA countries. If Neurogen exercises the profit sharing option,
     it will fund a portion of the cost of late stage clinical trials and
     marketing costs and in return receive a specified percentage of any profit
     generated by sales of collaboration products in NAFTA countries. If
     Neurogen chooses not to exercise its profit-sharing option, Pfizer would
     pay Neurogen royalties on drugs marketed in NAFTA countries and would fund
     a majority of early stage and all late stage development and marketing
     expenses. In either case, Neurogen would be entitled to royalties on drugs
     marketed in
<PAGE>
 
     non-NAFTA countries. As of March 31, 1997, Pfizer had provided $3.6 million
     in research funding (including $0.2 million in unearned revenues) pursuant
     to the 1995 Pfizer Agreement.

       In June 1995, Neurogen and Schering-Plough entered into a collaborative 
     agreement (the "Schering-Plough Agreement") to collaborate in the discovery
     and development of drugs for the treatment of schizophrenia and other
     disorders which act through the dopamine family of receptors. Pursuant to
     the Schering-Plough Agreement, the Company received one-time license fees
     of $14 million for rights relating to Neurogen's dopamine program and $3
     million in 1995 and 1996 for the right to test certain of Neurogen's
     combinatorial chemistry libraries in selected non-CNS assays. Neurogen has
     received or expects to receive an aggregate of approximately $7.2 million
     during the two-year period which commenced June 28, 1995, for research and
     development funding of the Company's dopamine program. The Company may
     receive additional research and development funding of up to $3.6 million
     per year for three additional one-year periods depending on whether and the
     extent to which Schering-Plough exercises its right to extend the research
     program under the collaboration. In March 1997, Neurogen received notice
     from Schering-Plough of its election to extend the research program under
     the Schering-Plough Agreement for an additional one-year period, through
     June 1998, pending the parties' adoption of a formal research plan relating
     to the extension period. Neurogen could also receive milestone payments of
     up to approximately $32 million if certain development and regulatory
     objectives are achieved regarding its products subject to the
     collaboration. In return, Schering-Plough received the exclusive worldwide
     license to market products subject to the collaboration and Neurogen
     retained the rights to receive royalties based on net sales levels, if any,
     and an option to manufacture products for the United States market. As of
     March 31, 1997, Schering-Plough had provided $7.2 million in research
     funding (including $0.9 million in unearned revenue) pursuant to the
     Schering-Plough Agreement. In addition to the payments described above,
     Schering-Plough is responsible for funding the cost of all clinical
     development and marketing, if any, of drugs subject to the collaboration.

       In the fourth quarter of 1996, Neurogen entered into an agreement with
     American Home Products Corporation, acting through its Wyeth-Ayerst
     Laboratories division.  Under the terms of the agreement, Neurogen received
     $0.75 million in license fees for ADCI, a small molecule pharmaceutical
     that Neurogen has been developing for the treatment of epilepsy and related
     disorders, and $0.75 million for 37,442 shares of common stock. Neurogen
     may receive up to an additional $11.0 million in the form of license fees,
     equity investment and milestone payments. Neurogen is also entitled to
     receive royalties on any world-wide sales of ADCI.

       The Company plans to use its cash balance for its research and
     development activities, working capital and general corporate purposes.
     Neurogen anticipates that its current cash balance, as supplemented by
     research funding pursuant to the Pfizer Agreements and the Schering-Plough
     Agreement, will be sufficient to fund its current and planned operations
     through 2000.  However, Neurogen's funding requirements may change and will
     depend upon numerous factors, including but not limited to, the progress of
     the Company's research and development 
<PAGE>
 
     programs, the timing and results of preclinical testing and clinical
     studies, the timing of regulatory approvals, technological advances,
     determinations as to the commercial potential of its proposed products, the
     status of competitive products and the ability of the Company to establish
     and maintain collaborative arrangements with others for the purpose of
     funding certain research and development programs, conducting clinical
     studies, obtaining regulatory approvals and, if such approvals are
     obtained, manufacturing and marketing products. The Company anticipates
     that it may augment its cash balance through financing transactions,
     including the issuance of debt or equity securities and further corporate
     alliances. No arrangements have been entered into for any future financing
     and no assurances can be given that adequate levels of additional funding
     can be obtained on favorable terms, if at all.

       As of December 31, 1996, the Company had approximately $11,490,000 of net
     operating loss carryforwards available for federal income tax purposes
     which expire from the years 2003 through 2009.  The Company had
     approximately $9,405,000 of Connecticut state tax net operating loss
     carryforwards as of December 31, 1996 which expire in the years 1997
     through 1999.  Because of "change in ownership" provisions of the Tax
     Reform Act of 1986, the Company's utilization of its net operating loss
     carryforwards may be subject to an annual limitation in future periods.
<PAGE>
 
                          PART II - OTHER INFORMATION


ITEM 1. LEGAL PROCEEDINGS

       Not applicable for the first quarter ended March 31, 1997.

ITEM 2. CHANGES IN SECURITIES

       Not applicable for the first quarter ended March 31, 1997.

ITEM 3. DEFAULTS UPON SENIOR SECURITIES

       Not applicable for the first quarter ended March 31, 1997.

ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

       Not applicable for the first quarter ended March 31, 1997.

ITEM 5. OTHER INFORMATION

       Not applicable for the first quarter ended March 31, 1997.

ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K

      (a) See Exhibit Index on page 11.
 
      (b) Exhibits and Reports on Form 8-K.
 
      The Company filed a Current Report on Form 8-K on March 31, 1997 to submit
for filing (confidential treatment requested) a Licensing Agreement and Stock
Purchase Agreement dated November 25, 1996 between American Home Products
Corporation, acting through its Wyeth-Ayerst Laboratories Division, and Neurogen
Corporation.



SAFE HARBOR STATEMENT

Statements which are not historical facts, including statements about the
Company's confidence and strategies, the status of various product development
programs, the sufficiency of cash to fund planned operations and the Company's
expectations concerning its development compounds, drug discovery technologies
and opportunities in the pharmaceutical marketplace are "forward looking
statements" within the meaning of the Private Securities Litigations Reform Act
of 1995 that involve risks and uncertainties and are not guarantees of future
performance.  These risks include, but are not limited to, difficulties or
delays in development, testing, regulatory approval, production and marketing of
any of the Company's drug candidates, the failure to attract or retain
scientific management personnel, any unexpected adverse side effects or
inadequate therapeutic efficacy of the Company's drug candidates which could
slow or prevent product development efforts, competition within the Company's
anticipated product markets, the Company's dependence on corporate partners with
respect to research and development funding, regulatory filings and
manufacturing and marketing expertise, the uncertainty of product development in
the pharmaceutical industry, inability to obtain sufficient funds through 
<PAGE>
 
future collaborative arrangements, equity or debt financings or other sources to
continue the operation of the Company's business, risk that patents and
confidentiality agreements will not adequately protect the Company's
intellectual property or trade secrets, dependence upon third parties for the
manufacture of potential products, inexperience in manufacturing and lack of
internal manufacturing capabilities, dependence on third parties to market
potential products, lack of sales and marketing capabilities, potential
unavailability or inadequacy of medical insurance or other third-party
reimbursement for the cost of purchases of the Company's products, and other
risks detailed in the Company's Securities and Exchange Commission filings,
including its Annual Report on Form 10-K for the year ended December 31, 1996,
each of which could adversely affect the Company's business and the accuracy of
the forward-looking statements contained herein.
<PAGE>
 
                                   Signature



     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.


                                      NEUROGEN CORPORATION



                                      By:/s/   STEPHEN R. DAVIS
                                        -----------------------
                                         Stephen R. Davis
                                         Vice President-Finance and
                                         Chief Financial Officer


Date:  May 15, 1997
<PAGE>
 
                                 Exhibit Index
                                 -------------

     Exhibit
     -------
     Number
     ------
     10.1   -     Neurogen Corporation Stock Option Plan, as amended
                  (incorporated by reference to Exhibit 10.1 to the Company's
                  Form 10-K for the fiscal year ended December 31, 1991).

     10.2   -     Form of Stock Option Agreement currently used in connection
                  with the grant of options under Neurogen Corporation Stock
                  Option Plan (incorporated by reference to Exhibit 10.2 to the
                  Company's Form 10-K for the fiscal year ended December 31,
                  1992).

     10.3   -     Neurogen Corporation 1993 Omnibus Incentive Plan, as amended
                  (incorporated by reference to Exhibit 10.3 to the Company's
                  Form 10-K for the fiscal year ended December 31, 1993).

     10.4   -     Form of Stock Option Agreement currently used in connection
                  with the grant of options under Neurogen Corporation 1993
                  Omnibus Incentive Plan (incorporated by reference to Exhibit
                  10.4 to the Company's Form 10-K for the fiscal year ended
                  December 31, 1993).

     10.5   -     Neurogen Corporation 1993 Non-Employee Directors Stock Option
                  Program (incorporated by reference to Exhibit 10.5 to the
                  Company's Form 10-K for the fiscal year ended December 31,
                  1993).

     10.6   -     Form of Stock Option Agreement currently used in connection
                  with the grant of options under Neurogen Corporation 1993 Non-
                  Employee Directors Stock Option Program (incorporated by
                  reference to Exhibit 10.6 to the Company's Form 10-K for the
                  fiscal year ended December 31, 1993).

     10.7   -     Employment Contract between the Company and Harry H. Penner,
                  Jr., dated as of October 12, 1993 (incorporated by reference
                  to Exhibit 10.7 to the Company's Form 10-K for the fiscal year
                  ended December 31, 1993).

     10.8   -     Employment Contract between the Company and John F. Tallman,
                  dated as of December 1, 1993 (incorporated by reference to
                  Exhibit 10.25 to the Company's Form 10-Q for the quarterly
                  period ended September 30, 1994).

     10.9   -     Open-End Mortgage Deed and Security Agreement between the
                  Company and Orion Machinery & Engineering Corp., dated March
                  16, 1989 (incorporated by reference to Exhibit 10.15 to
                  Registration Statement No. 33-29709 on Form S-1).

     10.10  -     Form of Proprietary Information and Inventions Agreement
                  (incorporated by reference to Exhibit 10.31 to Registration
                  Statement No. 33-29709 on Form S-1).
<PAGE>
 
     10.11  -     Warrant to Purchase 47,058 Shares of Common Stock to MMC/GATX
                  Partnership No. I, dated February 20, 1991 (incorporated by
                  reference to Exhibit 10.34 to the Company's Form 10-K for the
                  fiscal year ended December 31, 1990).

     10.12  -     Collaborative Research Agreement  and License and Royalty
                  Agreement between the Company and Pfizer Inc, dated as of
                  January 1, 1992 (confidential treatment requested)
                  (incorporated by reference to Exhibit 10.35 to the Company's
                  Form 10-K for the fiscal year ended December 31, 1991).

     10.13  -     License Agreement between the Company and the National
                  Technical Information Service, dated as of January 1, 1992
                  (incorporated by reference to Exhibit 10.36 to the Company's
                  Form 10-K for the fiscal year ended December 31, 1991).

     10.14  -     Cooperative Research and Development Agreement between the
                  Company and the National Institutes of Health, dated as of
                  January 21, 1993 (incorporated by reference to Exhibit 10.37
                  to the Company's Form 10-K for the fiscal year ended December
                  31, 1991).

     10.15  -     Letter Agreement between the Company and Barry M. Bloom, dated
                  January 12, 1994 (incorporated by reference to Exhibit 10.25
                  to the Company's Form 10-K for the fiscal year ended December
                  31, 1993).

     10.16  -     Letter Agreement between the Company and Robert H. Roth, dated
                  April 14, 1994 (incorporated by reference to Exhibit 10.26 to
                  the Company's Form 10-K for the fiscal year ended December 31,
                  1994).

     10.17  -     Collaborative Research Agreement and License and Royalty
                  Agreement between the Company and Pfizer Inc, dated as of July
                  1, 1994 (confidential treatment requested) (incorporated by
                  reference of Exhibit 10.1 to the Company's Form 10-Q for the
                  quarterly period ended June 30, 1994).

     10.18  -     Stock Purchase Agreement between the Company and Pfizer dated
                  as of July 1, 1994 (incorporated by reference to Exhibit 10.2
                  to the Company's Form 10-Q for the quarterly period ended June
                  30, 1994).

     10.19  -     Registration Rights and Standstill Agreement among the Company
                  and the Persons and Entities listed on Schedule I thereto,
                  dated as of July 11, 1994 (incorporated by reference to
                  Exhibit 10.29 to the Company's Form 10-Q for the quarterly
                  period ended September 30, 1994).

     10.20  -     Collaboration and License Agreement and Screening Agreement
                  between the Company and Schering-Plough Corporation
                  (confidential treatment requested) (incorporated by reference
                  to Exhibit 10.1 to the Company's Form 8-K dated July 28,
                  1995).
<PAGE>
 
     10.21  -     Lease Agreement between the Company and Commercial Building
                  Associates dated as of August 30, 1995 (incorporated by
                  reference to Exhibit 10.27 to the Company's Form 10-Q for the
                  quarterly period ended September 30, 1995).

     10.22  -     Collaborative Research Agreement between the Company and
                  Pfizer dated as of November 1, 1995 (confidential treatment
                  requested) (incorporated by reference to Exhibit 10.1 of the
                  Company's Form 8-K dated November 1, 1995).

     10.23        Development and Commercialization Agreement between the
                  Company and Pfizer dated as of November 1, 1995 (confidential
                  treatment requested) (incorporated by reference to Exhibit
                  10.2 of the Company's Form 8-K dated November 1, 1995).

     10.24  -     Stock Purchase Agreement between the Company and Pfizer dated
                  as of November 1, 1995 (incorporated by reference to Exhibit
                  10.3 of the Company's Form 8-K dated November 1, 1995).

     10. 25 -     Licensing Agreement dated as of November 25, 1996 between
                  American Home Products Corporation, acting through its Wyeth-
                  Ayerst Laboratories Division, and Neurogen Corporation
                  (CONFIDENTIAL TREATMENT REQUESTED) (incorporated by reference
                  to Exhibit 10.1 of the Company's Form 8-K dated March 31,
                  1997).

     10. 26 -     Stock Purchase Agreement dated as of November 25, 1996 between
                  American Home Products Corporation, acting through its Wyeth-
                  Ayerst Laboratories Division, and Neurogen Corporation
                  (CONFIDENTIAL TREATMENT REQUESTED) (incorporated by reference
                  to Exhibit 10.1 of the Company's Form 8-K dated March 31,
                  1997).

     11.1   -     Computation of Earnings per Common Share.
 
     27.1   -     Financial Data Schedule

<PAGE>
                                                             Exhibit 11.1

                             Neurogen Corporation
                 Computation of Net Earnings Per Common Share
         (in thousands, except Net Earnings per Common Share amounts)

                                 Three Months         Three Months
                                    Ended               Ended
                               March 31, 1997       March 31, 1996
                                 (Unaudited)         (Unaudited)
                                 -----------         -----------



Weighted average shares of
  common stock outstanding             14,282              14,020

Dilutive effect of :
    Warrants                               36                  43
    Stock options                       1,048               1,484
                                 -------------       -------------

Common and common
  equivalent shares                    15,366              15,547
                                 =============       =============

Net income                       $      2,850     $         3,610
                                 =============       =============

Earnings per common and
  common equivalent shares       $       0.19     $          0.23
                                 =============       =============

<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          DEC-31-1997
<PERIOD-START>                             JAN-01-1997
<PERIOD-END>                               MAR-31-1997
<CASH>                                          73,305
<SECURITIES>                                    20,470
<RECEIVABLES>                                        0
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                                95,296
<PP&E>                                          21,403
<DEPRECIATION>                                   3,524
<TOTAL-ASSETS>                                 113,575
<CURRENT-LIABILITIES>                            3,799
<BONDS>                                              0
                                0
                                          0
<COMMON>                                           358
<OTHER-SE>                                        (132)
<TOTAL-LIABILITY-AND-EQUITY>                   113,575
<SALES>                                              0
<TOTAL-REVENUES>                                 6,979
<CGS>                                                0
<TOTAL-COSTS>                                    5,324
<OTHER-EXPENSES>                                (1,230)
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                  11
<INCOME-PRETAX>                                  2,885
<INCOME-TAX>                                        35
<INCOME-CONTINUING>                              2,850
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                     2,850
<EPS-PRIMARY>                                      .19
<EPS-DILUTED>                                      .19
        
                                                   

</TABLE>


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