NEUROGEN CORP
SC 13D, 1997-04-21
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934   
                               (Amendment No.___)*

                              Neurogen Corporation
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.025 par value
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)
                                   
                                    64124E106
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                                
                                 Thomas J. Tisch
                               667 Madison Avenue
                               New York, NY 10021
                                 (212) 545-2927
- --------------------------------------------------------------------------------
(Name, Address and Telephone Number of Person Authorized to Receive Notices and
                                Communications)

                                 April 11, 1997
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule  because of Rule  13d-1(b)(3) or (4), check the following box |_|

Note: Six copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule  13d-1(a) for other  parties to whom copies are to be
sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



<PAGE>



                                  SCHEDULE 13D

- -------------------                                           ------------------
CUSIP No. 64124E106                                           Page 2 of 10 Pages
- --------------------                                          ------------------

- --------------------------------------------------------------------------------
   1     NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


         Four Partners
- --------------------------------------------------------------------------------
   2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*              (a)  |_|
                                                                        (b)  |_|
- --------------------------------------------------------------------------------
   3     SEC USE ONLY

- --------------------------------------------------------------------------------
   4     SOURCE OF FUNDS*

         WC
- --------------------------------------------------------------------------------
   5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT  
         TO ITEMS 2(d) or 2(e)                                               |_|

- --------------------------------------------------------------------------------
   6     CITIZENSHIP OR PLACE OF ORGANIZATION

         New York
- --------------------------------------------------------------------------------

                     
    NUMBER OF        7     SOLE VOTING POWER

     SHARES                771,900
                   -------------------------------------------------------------
                     
  BENEFICIALLY       8     SHARED VOTING POWER

    OWNED BY               -0-
                   -------------------------------------------------------------
      EACH           
                     9     SOLE DISPOSITIVE POWER
    REPORTING
                           771,900
     PERSON        -------------------------------------------------------------
                    
                     10    SHARED DISPOSITIVE POWER
      WITH
                           -0-
- --------------------------------------------------------------------------------

   11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         771,900
- --------------------------------------------------------------------------------

   12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                             |_|
- --------------------------------------------------------------------------------

   13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         5.4%
- --------------------------------------------------------------------------------

   14    TYPE OF REPORTING PERSON*

         PN
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
      (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.


<PAGE>



- --------------------------------------------------------------------------------
CUSIP NO. 64124E106                    13D                    Page 3 of 10 Pages
- --------------------------------------------------------------------------------

Item 1.  Security and Issuer.
         -------------------
         
        This Statement  relates to the Common Stock,  $.025 par value per share
(the "Common  Stock"),  of Neurogen  Corporation  (the "Issuer").  The principal
executive  offices of the Issuer are located at 35  Northeast  Industrial  Road,
Branford, Connecticut 06405.

Item 2.  Identity and Background.
         -----------------------

         This  statement  is being filed by Four  Partners,  a New York  general
partnership ("FP"). The principal business of FP is investments.  The address of
the principal  business and the  principal  office of FP is c/o Thomas J. Tisch,
667 Madison Avenue, New York, New York 10021. The sole partners of FP are Andrew
H. Tisch 1991 Trust, for which Andrew H. Tisch is the managing  trustee,  Daniel
R. Tisch 1991 Trust, for which Daniel R. Tisch is the managing trustee, James S.
Tisch 1991 Trust, for which James S. Tisch is the managing  trustee,  and Thomas
J. Tisch 1991 Trust, for which Thomas J. Tisch is the managing  trustee.  Thomas
J. Tisch has been appointed the Manager of FP.

         Set forth below is certain information with respect to Andrew H. Tisch,
Daniel R. Tisch, James S. Tisch and Thomas J. Tisch (the "Messrs.  Tisch"),  who
are the respective managing trustees of the four partners of FP:
<PAGE>

- --------------------------------------------------------------------------------
CUSIP NO. 64124E106                    13D                    Page 4 of 10 Pages
- --------------------------------------------------------------------------------

                                                   
Name                    Business Address           Present Principal Occupation
- ----                    ----------------           -----------------------------
Andrew H. Tisch         667 Madison Avenue         Member, Management 
                        New York, NY  10021        Committee, Loews Corporation 
                                                   (a public company primarily 
                                                   engaged in insurance and  
                                                   tobacco)

Daniel R. Tisch         c/o Mentor Partners, L.P.  General Partner, Mentor 
                        499 Park Avenue            Partners, L.P.(a partnership
                        New York, NY  10022        engaged in investment 
                                                   activities)

James S. Tisch          667 Madison Avenue         President and Chief Operating
                        New York, NY  10021        Officer, Loews Corporation 
                                                   (a public company primarily 
                                                   engaged in insurance and 
                                                   tobacco)

Thomas J. Tisch         667 Madison Avenue         Managing Partner of FLF 
                        New York, NY  10021        Associates and Manager of FP 
                                                   (partnerships engaged in 
                                                   investment activities)
                                                                       
         The Messrs. Tisch are brothers and are United States citizens.

         During the last five years,  none of the persons or the entities  named
in this Item 2 has been convicted in any criminal proceeding  (excluding traffic
violations  or similar  misdemeanors),  and none of the persons or the  entities
named in this Item 2 has been a party to a civil  proceeding  of a  judicial  or
administrative  body of  competent  jurisdiction  resulting  in its or his being
subject to a judgment, decree or

<PAGE>
- --------------------------------------------------------------------------------
CUSIP NO. 64124E106                    13D                    Page 5 of 10 Pages
- --------------------------------------------------------------------------------

final  order  enjoining  future  violations  of,  or  prohibiting  or  mandating
activities  subject  to,  federal  or state  securities  laws,  or  finding  any
violations with respect to such laws.


Item 3.  Source and Amount of Funds or Other Consideration.
         -------------------------------------------------

         All funds used to purchase the securities reported in Item 5 below were
provided from the working  capital of FP. The aggregate  purchase  price of such
securities was approximately $12,380,478.


Item 4.  Purpose of Transaction.
         ----------------------

         The securities purchased by FP were purchased solely for investment. FP
expects that it will, from time to time,  review its investment  position in the
Issuer and may,  depending on market and other conditions,  increase or decrease
such investment position.

         FP has no intention of seeking control of the Issuer,  nor does it have
any plans or proposals with respect to any extraordinary  corporate  transaction
involving  the  Issuer or any sale of its  assets or any  change in its Board of
Directors, management,  capitalization,  dividend policy, charter or by-laws, or
any other change in its  business or corporate  structure or with respect to the
delisting  or  deregistration  of  any  of  its  securities  including,  without
limitation,  those matters  described in subparagraphs (a) through (j) of Item 4
of Schedule 13D.
<PAGE>
- --------------------------------------------------------------------------------
CUSIP NO. 64124E106                    13D                    Page 6 of 10 Pages
- --------------------------------------------------------------------------------

Item 5.  Interest in Securities of the Issuer.
         ------------------------------------

         FP holds 771,900 shares, representing 5.4% of the outstanding shares of
Common Stock.

         (a) Set forth in the table below is the  aggregate  number of shares of
Common Stock  beneficially  owned as of the date hereof by each person or entity
listed in Item 2 above,  together with the percentage of  outstanding  shares of
Common Stock which is beneficially owned by each such person or entity.

<PAGE>

- --------------------------------------------------------------------------------
CUSIP NO. 64124E106                    13D                    Page 7 of 10 Pages
- --------------------------------------------------------------------------------

Name of                  Amount and Nature                   % of Class 
Beneficial Owner         of Beneficial Ownership             Outstanding (1)
- ----------------         -----------------------             ---------------
Four Partners                 771,900                        5.4%
                                                                              
                                                                            
                                                                   
Andrew H. Tisch                     0 (2)                    0
1991 Trust 

Daniel R. Tisch                     0 (2)                    0
1991 Trust   

James S. Tisch                      0 (2)                    0
1991 Trust

Thomas J. Tisch                     0 (2)                    0
1991 Trust                                     

Andrew H. Tisch                     0 (2)                    0

Daniel R. Tisch                     0 (2)                    0

James S. Tisch                      0 (2)                    0

Thomas J. Tisch                     0 (2)                    0
                              -------                        -
Total                         771,900                        5.4% (2)

         (b) With  respect to the  persons  and  entities  named in  response to
paragraph (a) above:

         (i) FP has  directly  the  sole  power to vote or  direct  the vote and
         dispose or direct the disposition of the 771,900 shares of Common Stock
         owned by it; and

         (ii) By virtue of their status as managing trustees of the trusts which
         are the general partners of FP, the Messrs. Tisch may be deemed to have
         indirectly  shared  power to vote or  direct  the vote and  dispose  or
         direct 

- ----------
     (1) The  Issuer's  10-K for the fiscal  year ended  December  31,  1996
         indicated  that  14,272,479  shares of Common  Stock  were  issued  and
         outstanding as of March 1, 1997.

     (2) Does  not  include  shares  owned  by FP.  None  of the  Messrs.  
         Tisch  beneficially  owns any  shares  of Common  Stock,  except to the
         extent that beneficial ownership of shares of Common Stock beneficially
         owned by FP may be attributed to them.
<PAGE>

- --------------------------------------------------------------------------------
CUSIP NO. 64124E106                    13D                    Page 8 of 10 Pages
- -------------------------------------------------------------------------------

         the disposition of the 771,900 shares of Common Stock owned by FP.
         
         (c) The  following  transactions  were  effected by FP during the sixty
days preceding the date hereof.  None of the persons or entities named in Item 2
above  effected  any other  transactions  in the Common Stock during the 60 days
preceding the date hereof.


Transaction    Date         Security     No.       Price/Share     Market
- -----------    ----         --------     -------   -----------     ------
Purchase       3/6/97        Common      80,000      $17.50        NASDAQ
Purchase       3/6/97        Common         200      $17.29        NASDAQ
Purchase       3/6/97        Common         500      $17.35        NASDAQ
Purchase       3/14/97       Common       2,200      $19.29        NASDAQ
Purchase       3/31/97       Common      12,500      $18.77        NASDAQ
Purchase       3/31/97       Common       2,000      $18.79        NASDAQ
Purchase       4/1/97        Common       3,000      $18.04        NASDAQ
Purchase       4/2/97        Common      32,000      $15.71        NASDAQ
Purchase       4/3/97        Common      24,000      $14.36        NASDAQ
Purchase       4/8/97        Common       4,000      $13.91        NASDAQ
Purchase       4/9/97        Common       2,000      $14.04        NASDAQ
Purchase       4/10/97       Common      35,400      $14.29        NASDAQ
Purchase       4/11/97       Common      10,000      $14.37        NASDAQ
Purchase       4/14/97       Common      14,800      $14.41        NASDAQ
Purchase       4/15/97       Common      33,200      $14.45        NASDAQ
Purchase       4/17/97       Common      2,500       $14.87        NASDAQ
Purchase       4/18/97       Common      5,000       $14.88        NASDAQ


<PAGE>

- --------------------------------------------------------------------------------
CUSIP NO. 64124E106                    13D                    Page 9 of 10 Pages
- --------------------------------------------------------------------------------

Item 6.  Contracts, Arrangements, Understandings or Relationships with Respect 
         ---------------------------------------------------------------------
         to Securities of the Issuer.
         ---------------------------

         None of the persons or  entities  named in Item 2 above has any express
contracts,  arrangements  or  understandings  with any of the other  persons  or
entities  named in Item 2 above with  respect to the  securities  of the Issuer.
Except as set forth in this Schedule 13D, none of the persons or entities  named
in Item 2 above has any contracts, arrangements, understandings or relationships
with any other person with respect to the securities of the Issuer.  None of the
persons  or  entities  named in Item 2 above  has any  contracts,  arrangements,
understandings or relationships with the Issuer.

Item 7.  Material to be filed as Exhibits.
         --------------------------------
                  
         None.
         ----

<PAGE>

- --------------------------------------------------------------------------------
CUSIP NO. 64124E106                    13D                   Page 10 of 10 Pages
- --------------------------------------------------------------------------------
                                                

                                    SIGNATURE

         After reasonable  inquiry and to the best of my knowledge and belief, I
hereby  certify  that  the  information  set  forth in this  statement  is true,
complete and correct.


April 21, 1997

                                                FOUR PARTNERS


                                                By  /s/ Thomas J. Tisch
                                                    ----------------------
                                                    Thomas J. Tisch
                                                    Manager of Four Partners

                                                                            

                                                                             
                                                                          



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