NEUROGEN CORP
SC 13D/A, 1997-12-15
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934
                               (Amendment No. 3)*

                              Neurogen Corporation
- -----------------------------------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.025 par value
- -----------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    64124E106
- -----------------------------------------------------------------------------
                                 (CUSIP Number)

                                 Thomas J. Tisch
                               667 Madison Avenue
                               New York, NY 10021
                                 (212) 545-2927
- -----------------------------------------------------------------------------
            (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)

                                December 12, 1997
- -----------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box |_|

Note: Six copies of this statement, including all exhibits, should be filed with
the Commission. See Rule 13d-1(a) for other parties to whom copies are to be
sent.

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


<PAGE>


                                  SCHEDULE 13D


CUSIP No. 64124E106                                      Page 2 of 5 Pages
- -----------------------------------------------------------------------------

- -------- --------------------------------------------------------------------
   
   1     NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON



         Four Partners
- -------- --------------------------------------------------------------------
   
   2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)  |_|

                                                                     (b)  |_|
- -------- --------------------------------------------------------------------
   
   3     SEC USE ONLY
- -------- --------------------------------------------------------------------
   
   4     SOURCE OF FUNDS*

         WC
- -------- --------------------------------------------------------------------
   
   5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) or 2(e)                                   |_|
- -------- --------------------------------------------------------------------
   
   6     CITIZENSHIP OR PLACE OF ORGANIZATION

         New York
- -----------------------------------------------------------------------------
                     
    NUMBER OF        7     SOLE VOTING POWER

     SHARES                1,408,200
                   ----------------------------------------------------------
                     
  BENEFICIALLY       8     SHARED VOTING POWER

    OWNED BY               -0-
                   ----------------------------------------------------------
      EACH           
                     9     SOLE DISPOSITIVE POWER
    REPORTING
                           1,408,200
                   ----------------------------------------------------------
     PERSON          
                     10    SHARED DISPOSITIVE POWER
      WITH
                           -0-
- -------- --------------------------------------------------------------------
   
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         1,408,200
- -------- --------------------------------------------------------------------
   
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
         CERTAIN SHARES*                                                  |_|
- -------- --------------------------------------------------------------------
   
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         9.8%
- -------- --------------------------------------------------------------------
   
14       TYPE OF REPORTING PERSON*

         PN
- -------- --------------------------------------------------------------------
   
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
          INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
      (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.


<PAGE>


- -----------------------------------------------------------------------------
CUSIP NO. 64124E106                13D                      Page 3 of 5 Pages
- -----------------------------------------------------------------------------


         This Amendment No. 3 amends the Schedule 13D filed by Four Partners, a
New York general partnership ("FP"), with the Securities and Exchange Commission
on April 21, 1997, as amended by Amendment No. 1 filed on June 19, 1997 and
Amendment No. 2 filed on August 7, 1997, and relates to the acquisition,
subsequent to the filing of Amendment No. 2 to the Schedule 13D, of an
additional 275,700 shares of the Common Stock, $.025 par value per share (the
"Common Stock"), of Neurogen Corporation (the "Issuer").

Item 3.  Source and Amount of Funds or Other Consideration.

         All funds used to purchase the securities reported in Item 5 below were
provided from the working capital of FP. The aggregate purchase price of such
securities was approximately $23,851,853.

Item 5.  Interest in Securities of the Issuer.

         FP holds 1,408,200 shares, representing 9.8% of the outstanding shares
of Common Stock.

         (a) Set forth in the table below is the aggregate number of shares of
Common Stock beneficially owned as of the date hereof by each person or entity
listed in Item 2 above, together with the percentage of outstanding shares of
Common Stock which is beneficially owned by each such person or entity.

<PAGE>


- -----------------------------------------------------------------------------
CUSIP NO. 64124E106                13D                      Page 4 of 5 Pages
- -----------------------------------------------------------------------------


Name of                Amount and Nature of            % of Class
Beneficial Owner       Beneficial Ownership            Outstanding (1)
- ----------------       --------------------            -----------
Four Partners             1,408,200                       9.8%

Andrew H. Tisch                   0 (2)                   0
1991 Trust

Daniel R. Tisch                   0 (2)                   0
1991 Trust

James S. Tisch                    0 (2)                   0
1991 Trust

Thomas J. Tisch                   0 (2)                   0
1991 Trust

Andrew H. Tisch                   0 (2)                   0

Daniel R. Tisch                   0 (2)                   0

James S. Tisch                    0 (2)                   0

Thomas J. Tisch                   0 (2)                   0
                   ----------------                       ----
Total                     1,408,200                       9.8%

         (b) With respect to the persons and entities named in response to
paragraph (a) above: 

         (i) FP has directly the sole power to vote or direct the vote and
    dispose or direct the disposition of the 1,408,200 shares of Common Stock
    owned by it;

         and (ii) By virtue of their status as managing trustees of the trusts
    which are the general partners of FP, the Messrs. Tisch may be deemed to
    have indirectly shared

- --------
(1) The Issuer's 10-Q for the fiscal quarter ended
    September 30, 1997 indicated that 14,390,786 shares of
    Common Stock were issued and outstanding as of
    November 13, 1997. 

(2) Does not include shares owned by FP. None of the Messrs.
    Tisch beneficially owns any shares of Common Stock,
    except to the extent that beneficial ownership of shares
    of Common Stock beneficially owned by FP may be
    attributed to them.

<PAGE>


- -----------------------------------------------------------------------------
CUSIP NO. 64124E106                13D                      Page 5 of 5 Pages
- -----------------------------------------------------------------------------


    power to vote or direct the vote and dispose or direct the disposition of
    the 1,408,200 shares of Common Stock owned by FP.

         (c) The following transactions were effected by FP during the sixty
days preceding the date hereof or since the most recent filing on Schedule 13D,
whichever is less. None of the persons or entities named in Item 2 above
effected any other transactions in the Common Stock during the 60 days preceding
the date hereof.


Transaction          Date       Security        No.    Price/Share      Market
- -----------          ----       --------        ---    -----------      ------
 Purchase          12/09/97      Common        50,000    $13.500        NASDAQ
 Purchase          12/12/97      Common       121,000    $14.125        NASDAQ

                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
hereby certify that the information set forth in this statement is true,
complete and correct.


December 15, 1997

                                                     FOUR PARTNERS


                                                     By /s/ Thomas J. Tisch
                                                            Thomas J. Tisch
                                                       Manager of Four Partners




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