NEUROGEN CORP
DEFS14A, 1998-10-14
PHARMACEUTICAL PREPARATIONS
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<PAGE>












                                                 


                              NEUROGEN CORPORATION



                                                              October 8, 1998



To the Stockholders of Neurogen Corporation:

         On behalf of the Board of Directors,  I cordially  invite you to attend
the 1998 Special Meeting of Stockholders  of Neurogen  Corporation.  The Special
Meeting will be held on Thursday,  November 5,  1998, at 3:00 p.m.,  local time,
at the New York Palace Hotel at 455 Madison Avenue, New York, New York.

         A description of business to be conducted at the Special Meeting is set
forth in the attached Notice of Special Meeting and Proxy Statement.

         It is important that your views be  represented  whether or not you are
able to be present at the Special  Meeting.  Please mark,  sign, date and return
the enclosed proxy card promptly in the accompanying  postage-paid  envelope. By
returning  the proxy,  you can help the Company  avoid the expense of  duplicate
proxy  solicitations  and possibly having to reschedule the Special Meeting if a
quorum of  outstanding  shares is not present or  represented  by proxy.  If you
attend the Special  Meeting  and wish to change  your proxy vote,  you may do so
simply by voting in person at the Special Meeting.


                                           Sincerely,


                                           HARRY H. PENNER, JR.
                                           President and Chief Executive Officer








<PAGE>

                              NEUROGEN CORPORATION

                    NOTICE OF SPECIAL MEETING OF STOCKHOLDERS

                         To Be Held on November 5, 1998


         NOTICE IS HEREBY  GIVEN that the  Special  Meeting of  Stockholders  of
Neurogen Corporation will be held on Thursday,  November 5,  1998, at 3:00 p.m.,
local time,  at the New  York  Palace  Hotel,  455  Madison  Avenue,   New York,
New York, for the following purposes:

         1. To adopt an  amendment  to the  Neurogen  Corporation  1993  Omnibus
Incentive Plan, which as originally  adopted provided for the granting of awards
aggregating  up to 3,000,000  shares of Common Stock.  Currently,  approximately
400,000 shares remain available for future awards.  The amendment will replenish
the plan by  increasing  the number of shares  available  for  future  awards by
adding 1,500,000 shares to the plan. This amendment is being proposed in lieu of
an  earlier  proposal  (the  "Withdrawn   Proposal")  made  in  connection  with
Neurogen's May 1998 Annual Meeting of  Shareholders,  which was withdrawn by the
Board at the  recommendation  of management  prior to such Annual  Meeting.  The
Withdrawn  Proposal would have  increased the shares  available in the Plan by a
larger number than this proposal.  Neurogen management believes that the smaller
addition to the Plan  represented by this proposal will provide for more regular
shareholder oversight and assessment of company performance.

         2. To  transact  such other  business as may  properly  come before the
meeting or any adjournment or adjournments thereof.

         This Notice is  accompanied  by a form of proxy and a Proxy  Statement.
The foregoing items of business are more fully described in the Proxy Statement.

         In  accordance  with the  Company's  By-laws,  the close of business on
September  15, 1998 has been fixed as the Record Date for the  determination  of
the  stockholders  entitled to notice of and to vote at the Special  Meeting and
any adjournment thereof.

                                                  JOHN F. TALLMAN
                                                  Secretary

Branford, Connecticut
October 8, 1998



                                    IMPORTANT


         To ensure your  representation  at the meeting,  you are urged to mark,
sign,  date and  return  the  enclosed  proxy as  promptly  as  possible  in the
postage-paid  envelope enclosed for that purpose. If you attend the meeting, you
may vote in person even if you returned a proxy.
                                      
<PAGE>                                                  
                              NEUROGEN CORPORATION
                                 PROXY STATEMENT
General
         The enclosed  proxy is solicited on behalf of the Board of Directors of
Neurogen  Corporation  (the  "Company"  or  "Neurogen")  for use at the  Special
Meeting of  Stockholders  to be  held on November 5, 1998,  at 3:00 p.m.,  local
time, or at any adjournment thereof (the "Special Meeting"). The Special Meeting
will be held  at the  New  York  Palace Hotel,  455  Madison  Avenue,  New York,
New York.  The  purposes of the Special  Meeting  are set forth in the  attached
Notice of Special Meeting of Stockholders.

         This Proxy Statement, the Notice of Special Meeting of Stockholders and
the form of proxy are being mailed to stockholders on or about October 8, 1998.

Record Date and Share Ownership
         Stockholders  of record on the Company's books at the close of business
on September  15, 1998 (the  "Record  Date") are entitled to vote at the Special
Meeting.  At the Record Date,  14,429,832  shares of the Company's Common Stock,
par value $.025 per share (the "Common Stock"), were issued and outstanding. For
information  concerning stock ownership by certain stockholders,  see "Principal
Stockholders".

Revocability of Proxies
         Any proxy  given  pursuant to this  solicitation  may be revoked by the
person  giving it at any time  before  its use by  delivering  to the  Company a
written notice of revocation prior to the voting of the proxy or a duly executed
proxy  bearing a later date or by  attending  the Special  Meeting and voting in
person.

Voting and Solicitation
         Each  stockholder  is entitled to one vote for each share of the Common
Stock  held of  record  in his or her  name on the  Record  Date on each  matter
submitted to a vote at the Special Meeting.  Cumulative  voting is not permitted
with respect to any proposal to be acted upon at the Special Meeting.

         If properly  executed  and  received by the Company  before the Special
Meeting,  any proxy representing  shares of Common Stock entitled to be voted at
the  Special  Meeting  and  specifying  how  it is to be  voted  will  be  voted
accordingly.  Any such  proxy,  however,  which fails to specify how it is to be
voted on a proposal for which a specification  may be made will be voted on such
proposal  in  accordance  with the  recommendation  of the  Board of  Directors.
Abstentions are counted in tabulations of the votes cast on proposals  presented
to  stockholders,   but  broker  non-votes  are  not  counted  for  purposes  of
determining whether a proposal has been approved.

         The  presence,  in person or by proxy,  of the holders of a majority of
the outstanding  shares of Common Stock entitled to vote at the Special Meeting,
excluding any shares owned by the Company,  is necessary to constitute a quorum.
Abstentions  and broker  non-votes are counted for purposes of  determining  the
presence or absence of a quorum for the transaction of business.

         The  cost of  soliciting  proxies  will be  borne  by the  Company.  In
addition,  the Company  expects to reimburse  brokerage  firms and other persons
representing  beneficial owners of Common Stock for their expenses in forwarding
solicitation  material to such  beneficial  owners.  Proxies may be solicited by
certain of the  Company's  directors,  officers and regular  employees,  without
additional compensation, in person or by mail, telephone, facsimile or telegram.

         Pursuant to Delaware  law,  the Board of  Directors  has  appointed  an
inspector  to act at the  Special  Meeting.  The  inspector  shall carry out the
duties imposed pursuant to Section 231 of the Delaware General  Corporation Law,
including the counting of votes.                                     

                                       3
<PAGE>

                             PRINCIPAL STOCKHOLDERS

         The  following  table sets  forth,  as of  September  1, 1998,  certain
information  with  respect to the  beneficial  ownership of Common Stock by each
person  known by  Neurogen  to own  beneficially  more than five  percent of its
outstanding  Common  Stock,  by each director and officer of Neurogen and by all
directors and officers as a group:
<TABLE>
<S>                                                            <C>                          <C>    
                                                            Amount and                   Approximate
    Name and Address                                   Nature of Beneficial                Percent
    of Beneficial Owner                                    Ownership(1)                    Owned(2)

Pfizer Inc    ....................................          2,846,000                        19.7%
   235 East 42nd Street
   New York, NY 10017
Biotechnology Value Fund..........................          1,918,906                        13.3%
   One Sansone Street
   San Francisco, CA  94104
Four Partners ....................................          1,225,800                         8.5%
   867 Madison Ave.
   New York, NY  10021
Franklin Resources Inc............................            793,000                         5.5%
   777 Mariners Island Blvd. 6th Floor
   San Mateo, CA  94404...........................
Harry Penner, Jr. (3).............................            308,836                         2.1%
John F. Tallman, Ph.D. (4)........................            258,011                         1.8%
Alan J. Hutchison, Ph.D. (5)......................             78,000                          *
Stephen R. Davis (6)..............................             52,500                          *
Barry M. Bloom, Ph.D. (7).........................             35,174                          *
Robert N. Butler, M.D. (8)........................             16,382                          *
Frank C. Carlucci (9)(11).........................            143,449                         1.0%
Jeffrey J. Collinson (7)(10)......................             69,186                          *
Robert M. Gardiner (7)............................             69,174                          *
Mark Novitch, M.D. (11)...........................             38,174                          *
Robert H. Roth, Ph.D. (12)........................             78,174                          *
John Simon (11)(13)...............................             67,678                          *
All directors and officers
   as a group (13 persons) (14)...................          1,220,785                         8.0%

</TABLE>

- ---------------
 *     Less than one percent (1%).


                                       
                                       4
<PAGE>

(1)    Share  ownership in each case includes  shares  issuable upon exercise of
       outstanding common stock options  exercisable within 60 days of September
       1, 1998.

(2)    Percentage  of the  outstanding  shares  of  Common  Stock,  treating  as
       outstanding  for each  beneficial  owner all shares of Common Stock which
       such  beneficial  owner has  indicated  are issuable  under stock options
       exercisable within 60 days of September 1, 1998.

(3)    Includes 294,000 shares of Common Stock that Harry H. Penner, Jr. has the
       right to  acquire  under  stock  options  exercisable  within  60 days of
       September 1, 1998.

(4)    Includes  109,800 shares of Common Stock that John F. Tallman,  Ph.D. has
       the right to acquire  under stock options  exercisable  within 60 days of
       September 1, 1998. Does not include 2,000 shares of Common Stock owned by
       Kathleen Person,  Dr. Tallman's  spouse.  Kathleen Person and Dr. Tallman
       disclaim beneficial ownership of each other's shares.

(5)    Includes 78,000 shares of Common Stock that Alan J. Hutchison, Ph.D., has
       the right to acquire  under stock options  exercisable  within 60 days of
       September 1, 1998.

(6)    Includes  52,500  shares of Common  Stock  that  Stephen R. Davis has the
       right to  acquire  under  stock  options  exercisable  within  60 days of
       September 1, 1998.

(7)    Includes 14,174  shares  of   Common   Stock  subject  to  stock  options
       exercisable within 60 days of September 1, 1998.


(8)    Includes   16,382  shares  of  Common  Stock  subject  to  stock  options
       exercisable  by Robert N.  Butler,  M.D.,  within 60 days of September 1,
       1998.

(9)    Does not include  40,000  shares of Common Stock owned by Mr.  Carlucci's
       wife.  Mr.  Carlucci and his wife disclaim  beneficial  ownership of each
       other's shares.

(10)   Includes  23,500 shares of Common Stock held by Schroder's  Incorporated,
       for which Mr. Collinson acts as  attorney-in-fact  and shares  investment
       and voting power,  and 3,880 shares of Common Stock held by a corporation
       which Mr. Collinson controls.

(11)   Includes  34,174  shares   of  Common  Stock  subject  to  stock  options
       exercisable within 60 days of September 1, 1998.

(12)   Includes   41,174  shares  of  Common  Stock  subject  to  stock  options
       exercisable by Robert H. Roth, Ph.D. within 60 days of September 1, 1998.

(13)   Does  not  include  shares  of  Common  Stock  held by  Allen  &  Company
       Incorporated  and by  persons  and  entities  which  may be  deemed to be
       affiliated with Allen & Company  Incorporated,  of which shares Mr. Simon
       disclaims beneficial ownership.

(14)   Includes 742,460 shares of Common Stock subject to stock options 
       exercisable within 60 days of September 1, 1998.
                                   
                                       5
<PAGE>

                               EXECUTIVE OFFICERS
The  executive  officers  of the  Company  who are  elected  by and serve at the
discretion of the Board of Directors, are as follows:
<TABLE>
<S>                          <C>               <C>                                 <C>    

      Name                    Age                 Position                   Officer Since


Harry H. Penner, Jr.          52       President and Chief Executive            December 1993
                                        Officer                               

John F. Tallman               51       Executive Vice President,                July 1988
                                        Secretary, Scientific Director,
                                        and Chairman of the Scientific
                                        Advisory Board                      

Alan J. Hutchison             44       Senior Vice President-Drug Discovery     June 1994

Stephen R. Davis              37       Vice President-Finance, Chief            July 1994
                                        Financial Officer and Treasurer
                                                           
</TABLE>
 
    
     Harry H. Penner,  Jr., has been President,  Chief  Executive  Officer and a
director  of Neurogen  since  December  1993.  Mr.  Penner was  employed by Novo
Nordisk  A/S from 1981 to 1993,  most  recently  serving  as an  Executive  Vice
President of Novo Nordisk A/S and as President of Novo Nordisk of North  America
Inc. Mr. Penner holds an L.L.M.  in  International  Law from New York University
and a J.D.  from  Fordham  University.  Mr.  Penner  also serves on the Board of
Directors of Anergen, Inc. and T Cell Sciences, Inc. (both of which are publicly
traded biotechnology companies),  and PRA International,  Inc. (a privately held
clinical research  organization).  Mr. Penner also chairs the Board of Directors
of the Connecticut Technology Council (CTC). In addition, Mr. Penner serves as a
member  of the Board of  Directors  of the  Connecticut  Business  and  Industry
Association  (CBIA) and the  Emerging  Companies  Section  of the  Biotechnology
Industry  Organization (BIO) and is a member of the professional  advisory board
of Connecticut United for Research Excellence (CURE).

     John F. Tallman,  Ph.D.,  has been  Executive  Vice  President,  Scientific
Director,  Chairman of the Scientific  Advisory Board and a director of Neurogen
since July 1988. Dr. Tallman has served as Secretary of the Company since August
1994.  Prior to joining  Neurogen,  Dr.  Tallman was an  Associate  Professor of
Psychiatry  and  Pharmacology  at Yale  University  and  currently  serves as an
Adjunct  Professor in such  departments.  Dr. Tallman had  previously  served in
research  director  positions  at the  National  Institute  of Mental  Health in
Bethesda,  Maryland.  Dr. Tallman  received his Ph.D. in Biology from Georgetown
University.                                      

     Alan J. Hutchison,  Ph.D.,  has been Vice  President--Drug  Discovery since
1992 and a member of  Neurogen's  Scientific  Advisory  Board  since  1989.  Dr.
Hutchison  joined  Neurogen in 1989 as Director of Chemistry.  From 1981 through
1989, Dr. Hutchison was employed by Ciba Giegy, most recently as a Distinguished
Research  Fellow.  Dr.  Hutchison  received his B.S. in  Chemistry  from Stevens
Institute of Technology and received his Ph.D. from Harvard University.

     Stephen R. Davis has been Vice President--Finance,  Chief Financial Officer
and  Treasurer of Neurogen  since July 1994.  From 1990  through June 1994,  Mr.
Davis  was  employed  by  Milbank,  Tweed,  Hadley & McCloy as a  corporate  and
securities  attorney.  Previously,  Mr. Davis  practiced  as a Certified  Public
Accountant  with Arthur Andersen & Co. Mr. Davis received his B.S. in Accounting
from Southern Nazarene University and a J.D. degree from Vanderbilt University.

                                       6
<PAGE>

                       Compensation of Executive Officers

Compensation Committee Report:1

         The Compensation  Committee of the Board of Directors consists entirely
of outside  directors  and is  responsible  for  setting and  administering  the
policies which govern both annual  compensation and stock ownership  programs of
the Company. The Compensation  Committee evaluates the performance of management
and determines the  compensation of Mr. Penner and the other executive  officers
of the Company on an annual basis.  The Committee has developed and  implemented
policies and programs  that seek to retain and  motivate  executive  officers in
furtherance  of the  Company's  goal  of  increasing  shareholder  value.  These
policies include the following objectives:

         o        Providing base salaries that take into consideration executive
                  compensation  paid by  other  biopharmaceutical  companies  of
                  similar  complexity  and financial  condition.  This objective
                  also takes into  account  the  competitive  demand for quality
                  personnel in the pharmaceutical and biotechnology  industries,
                  individual  experience and specific  issues  particular to the
                  Company.

         o        Providing periodic bonus awards for completion of significant
                  achievements or attainment of significant objectives.

         o        Providing  equity  participation  in the form of stock  option
                  grants for the purpose of aligning executive  officers' longer
                  term interests with those of the shareholders.

         In the  biopharmaceutical  industry,  traditional measures of corporate
performance,  such as earnings per share or sales growth,  may not readily apply
in reviewing  performance of executives.  Rather, at the Company's current stage
of development,  in determining the compensation of the Company's executives the
Compensation  Committee  looks to other  measures  of  performance,  such as the
progress of the  Company's  research  and  development  programs  and  corporate
development activities, the establishment and maintenance of strategic corporate
alliances and the Company's success in securing capital sufficient to assist the
Company in  advancing  and  expanding  its product  development,  including  the
funding of clinical trials. The Compensation Committee believes that outstanding
performance  in these  areas will  contribute  to the  long-term  success of the
Company  and  the  growth  of  shareholder  value.  The  Committee  specifically
considers the  achievement  of milestones  related to expansion of the Company's
portfolio of drug  development  programs and the progress of drug development in
each such program. In addition,  the Committee considers the extent to which the
Company's  shares have changed in value.  However,  the  Compensation  Committee
recognizes that, in the short-term, the market price of the Company's shares may
be affected by industry  events and market  conditions  which are  transient  in
nature and beyond the  control of  management.  This is  especially  true in the
biotechnology  industry,  which is characterized by long product lead times, the
inherently  unpredictable  nature of drug  development,  highly  volatile  stock
prices and fluctuating  availability of capital.  Accordingly,  the Compensation
Committee attempts to retain and appropriately motivate the Company's executives
by balancing the  consideration of shorter-term  strategic goals with objectives
which are essential in creating longer-term shareholder value.

         In many  instances the  qualitative  factors by which the  Compensation
Committee  judges  corporate   performance   necessarily  involve  a  subjective
assessment by the Committee of management's performance. Moreover, the Committee
does not base its  considerations on any single  performance  factor nor does it
specifically  assign relative weights to factors,  but rather considers a mix of
factors and evaluates Company and individual performance against that mix.
                                  

                                       7
<PAGE>

         Compensation paid by the Company to its executive  officers is designed
to be  competitive  with  compensation  packages paid to the management of other
companies   of   comparable   complexity   and   financial   condition   in  the
biopharmaceutical  industry.  Toward that end, the  Compensation  Committee  may
review both independent survey data as well as data gathered  internally.  Total
compensation  for  the  Company's  executive  officers  includes  a base  salary
component and may also include other forms of incentives. Incentive compensation
may  consist of cash  incentive  bonuses  based on  satisfying  corporate  goals
established  for  the  year  as  well  as  on  meeting  individual   performance
objectives. In addition, executive officers of the Company may receive incentive
compensation  under the Neurogen  Corporation  1993 Omnibus  Incentive Plan (the
"Incentive  Plan") such as grants of options to purchase shares of the Company's
Common  Stock,  with exercise  prices  typically set at fair market value on the
date of  grant.  Executive  compensation  may  also  include  loans,  which  are
typically forgiven over a period of five to seven years,  provided the recipient
remains employed by the Company during such period.

         Executive  officers are eligible for stock option  grants as an element
of their total annual compensation package. This component is intended to retain
and motivate executive officers to improve long-term stock performance.  Options
are awarded at the discretion of the Compensation  Committee.  In 1997, all four
of the Company's  executive  officers received options under the Incentive Plan.
These options are  exercisable  during the term of the option at the fair market
value of the  underlying  Common  Stock on the date of grant.  With  respect  to
twenty-five  percent of the year-end  1997 options  granted to these  executives
officers, the exercise price may drop to zero at the end of the ten year term of
the option,  but only if the officer has remained  employed by the Company for a
period of seven years from the date of grant.  Generally,  option grants vest in
equal  amounts over five years and have a ten year term.  As with cash  bonuses,
the number of options  to be granted to each  executive  officer is based on the
degree of  attainment of  predetermined  Company and personal  objectives,  with
emphasis,  in certain cases, on those which have long-term  strategic value. The
Company  generally  grants stock options to all employees and uses stock options
as a bonus vehicle. The Compensation Committee administers the Incentive Plan.

         During the fiscal years ended  December 31, 1996 and 1997,  the Company
made  significant  progress  in several  areas and met or  exceeded  most of its
performance   goals.  The  Compensation   Committee   considered  the  following
developments in 1996 in establishing the base salaries of the executive officers
for  fiscal  year  1996  and in  awarding  incentive  compensation  based on the
Company's  performance in 1996: the  establishment and integration of Neurogen's
AIDD program for drug  discovery,  which  includes the  Company's  combinatorial
chemistry,  high-throughput  screening,  informatics and robotics programs;  the
application  of the AIDD  program  to expand  the  Company's  portfolio  of drug
development  programs,  such as the  discovery  of drug  candidates  which  work
through the neurotransmitter  systems corticotrophin  releasing factor (CRF) and
galanin;  the  commencement  and  progress  of  human  clinical  trials  for the
Company's lead  anti-obesity  drug; the discovery and  advancement of additional
drug  candidates  in the  Company's  collaborative  programs  for drugs to treat
anxiety,  schizophrenia,  sleep disorders and cognition  enhancement;  the $10.5
                                       


                                       8
<PAGE>

million  extension  through  December 1998 of the research  programs with Pfizer
with respect to GABA-based drugs to treat anxiety, sleep disorders and cognition
impairment;  and the  consummation  of an agreement to license to American  Home
Products,  working through its Wyeth-Ayerst  Laboratories  division,  Neurogen's
rights to its anti-epilepsy  drug, ADCI. The Compensation  Committee  considered
the  following  developments  in 1997 in  establishing  the base salaries of the
executive officers for fiscal year 1998 and in awarding  incentive  compensation
based on the Company's  performance  in 1997: the  commencement  and progress of
human clinical trials for the Company's  anti-anxiety drug candidate,  NGD 91-2,
and  the  advancement  of  additional   drug  candidates  in  the   anti-anxiety
collaboration  with Pfizer;  the  commencement  and  progress of human  clinical
trials for the Company's  epilepsy drug  candidate,  ADCI;  the conduct of human
clinical  trials for the Company's  anti-obesity  drug  candidate,  NGD 95-1, to
explore  safety  and  therapeutic   potential  of  the  NPY  mechanism  and  the
advancement of additional drug candidates in the anti-obesity collaboration with
Pfizer;  the development  and selection of clinical  candidates in the Company's
insomnia and cognition  enhancement research programs partnered with Pfizer; the
discovery  and  advancement  of  additional  drug  candidates  in the  Company's
schizophrenia  drug program  partnered with  Schering-Plough;  the discovery and
advancement  of a new class of compounds in the  Company's  CRF stress  disorder
program;  and the further  advancement  of the Company's  proprietary  AIDD drug
discovery  program and the  application  of this  technology  to  discover  drug
candidates in new areas,  including CRF agonists for the potential  treatment of
obesity and GLP1  agonists  for the  potential  treatment  of Type II  diabetes,
thereby  expanding  the  Company's  portfolio  of drug  development  programs to
eleven.  The Compensation  Committee believes that the commitment and leadership
of the  Company's  executive  officers were  important  factors in the Company's
achievements in fiscal 1997.

         In  December  1997,  the  Compensation  Committee  met  to  review  the
Company's  performance and the performance of the Company's  executive  officers
during fiscal 1997, to determine cash incentive  bonuses and stock option grants
to such  executive  officers and to set base salary levels for fiscal 1998.  Mr.
Penner  is not  present  during  the  Compensation  Committee's  discussion  and
determination of his compensation.  In recognition of the achievement of Company
and individual  performance criteria outlined above, the Compensation  Committee
approved  increases in the base salaries of, and awarded cash incentive  bonuses
and stock  options to, all the  executive  officers  including  Mr. Penner whose
compensation is further described below.

         CEO  Compensation - In evaluating the  compensation of Harry H. Penner,
Jr., the Committee  considered the significant role Mr. Penner played in each of
the above noted  accomplishments.  In December 1997, the Compensation  Committee
raised Mr. Penner's base salary from $340,000 to $357,000, effective December 1,
1997,  and awarded Mr. Penner a cash bonus of $136,000 or 38 percent of his base
salary.  As  additional  recognition  of Mr.  Penner's  efforts in 1997,  and in
furtherance of the Committee's belief that a substantial portion of Mr. Penner's
total  compensation  should be dependent on the  long-term  appreciation  of the
Company's stock price, in December the Committee granted Mr. Penner an option to
purchase  80,000 shares of Neurogen Common Stock pursuant to the Incentive Plan.
Mr.  Penner's salary  increase and awards reflect the  Compensation  Committee's
assessment  of his  very  favorable  performance  and  his  contribution  to the
Company's achievement of significant milestones.

         By the Compensation Committee:  Robert M. Gardiner, Frank C. Carlucci, 
         and Jeffrey J. Collinson.

                                      


                                       9
<PAGE>






         For the three  years ended  December  31,  1997,  1996,  and 1995,  the
Company paid the amounts  shown in the  following  table with respect to each of
the executive officers of the Company.

                           Summary Compensation Table
<TABLE>
                                                                                                         Long-Term
                                                                        Annual                          Compensation
                                                                     Compensation                         Awards
                                                                                               Securities       All Other
                                                                              Other Annual     Underlying        Compen-
Name and Principal                      Year      Salary          Bonus       Compensation     Options(a)        sation
Position                                           ($)             ($)            ($)             (#)              ($)
<S>                                      <C>       <C>             <C>              <C>            <C>             <C>

- -----------------------                 ----    --------         -------        ---------      ---------        ---------
Harry H. Penner, Jr.                    1997     340,000         136,000         45,206(b)       80,000          8,636(c)
President and Chief                     1996     311,583         122,000         41,605(d)       80,000          9,586(c)
Executive Officer                       1995     295,250         147,000        118,898(e)      100,000          7,704(c)

                                        1997     215,000          80,000         33,904(f)       60,000          5,752(c)
John F. Tallman                         1996     201,250          70,000         31,205(g)       60,000          5,772(c)
Executive Vice-President,               1995     190,833          95,000          6,529(h)       75,000          3,811(c)
President, Scientific Director
and Secretary

Alan J. Hutchison                       1997     193,500          70,000         31,493(i)       50,000          3,877(c)
Vice President-Drug Discovery           1996     180,000          40,000         47,387(j)       40,000          3,029(c)
                                        1995     170,000          60,000         55,710(k)       50,000            782(l)

Stephen R. Davis                        1997     167,700          45,000          7,639(m)       25,000          3,705(c)
Vice President-Finance,                 1996     156,000          39,000          6,222(n)       25,000          3,796(k)
Chief Financial Officer, Treasurer      1995     148,630          50,000         28,687(o)       31,250            414(k)
- ------------------
</TABLE>

                                       


                                       10
<PAGE>

(a)    References to SARs in the Summary Compensation Table and all other tables
       in this Proxy  Statement  have been omitted,  since the Company has never
       issued  SARs,  although  under  the  Neurogen  Corporation  1993  Omnibus
       Incentive Plan it has the ability to do so.
(b)    Includes  $28,571 of  forgiveness  of loan,  forgiveness  of  interest of
       $9,058 on loan and income tax reimbursements of $7,577.
(c)    Includes premiums for life insurance,  and matching contribution received
       from participation in the Company's 401(k) plan.
(d)    Includes  $28,571 of  forgiveness  of loan,  forgiveness  of  interest of
       $7,097 on loan and income tax reimbursements of $5,937.
(e)    Includes  forgiveness of interest of $4,740 on loan,  relocation expenses
       of $60,000  and income tax  reimbursement  of $54,158.  While Mr.  Penner
       commenced  employment  with the Company in December  1993, his relocation
       expenses and related income tax reimbursements were not paid until 1995.
(f)    Includes $21,429 of forgiveness of loan, forgiveness of interest of 
       $6,793 and income tax reimbursements of $5,683.
(g)    Includes  $21,429 of  forgiveness  of loan,  forgiveness  of  interest of
       $5,323 on loan and income tax reimbursements of $4,453.
(h)    Includes forgiveness of interest on loan and income tax reimbursements.
(i)    Includes $21,429 of forgiveness of loan, forgiveness of interest of 
       $5,480 and income tax reimbursements of $4,584.
(j)    Includes forgiveness of loan of $21,429, forgiveness of interest of 
       $4,373 of loan and income tax reimbursement of $21,585.
(k)    Includes  $21,429 of  forgiveness  of loan,  forgiveness  of  interest of
       $8,905 on loan and income tax reimbursements of $25,376.
(l)    Includes premiums for life insurance.
(m)    Includes $5,000 of forgiveness of loan, forgiveness of interest of $1,437
       and income tax reimbursements of
       $1,202.
(n)    Includes forgiveness of loan of $5,000, forgiveness of interest of $665
       of loan and income tax reimbursements of $557.
(o)    Includes $5,000 of forgiveness of loan, forgiveness of interest of $2,290
       on loan,  relocation  expenses of $9,760 and income tax reimbursements of
       $11,637.  While Mr. Davis  commenced  employment with the Company in July
       1994 his relocation  expenses and related income tax reimbursements  were
       not paid until 1995.




                                       


                                       11
<PAGE>






         For the year ended  December 31, 1997, the following  tables  summarize
incentive compensation paid to executive officers.
<TABLE>


                                      Option Grants in Last Fiscal Year
                                                                                           
                                                                                           
                            Number of                                                       
                            Securities     % of Total                                       Potential Realizable Value 
                            Underlying    Options Granted    Exercise or                    at Assumed Annual Rates of
           Name              Options      to Employees in     Base Price   Expiration        Stock Price Appreciation
                             Granted       Fiscal Year        ($/Share)       Date               for Option Term

                                                                                               5%($)         10%($)
                                                                                               -----         ------
<S>                             <C>           <C>            <C>               <C>               <C>          <C>

Harry H. Penner, Jr.          80,000*        11%               13.50*       12/31/07          $679,206     $1,721,242
John F. Tallman               60,000*         8%               13.50*       12/31/07           509,405      1,290,931
Alan J. Hutchison             40,000*         7%               13.50*       12/31/07           424,504      1,075,776
Stephen R. Davis              25,000*         3%               13.50*       12/31/07           212,252        537,888
</TABLE>

* With respect to twenty-five percent (25%) of the year-end 1997 options granted
to these executive  officers,  the exercise price may drop to zero at the end of
the ten year term of the option,  but only if the officer has remained  employed
by the Company for a period of seven (7) years from the date of grant.
<TABLE>

                                 Aggregated Option Exercises in Last Fiscal Year
                                      and Fiscal Year-End Option Values

                                                        Number of Securities Underlying         Value of Unexercised
                              Shares                        Unexercised Options at         In-the-Money Options at Fiscal
                           Acquired on       Value             Fiscal Year-End                     Year-End($)(a)
                           Exercise(#)     Realized        Exercisable/Unexercisable         Exercisable/Unexercisable
      Name                                  ($)(a)
<S>                            <C>             <C>                    <C>                              <C>    

Harry H. Penner, Jr.            -              -                294,000/296,000                 $1,654,000/$636,000
John F. Tallman                 -              -                106,000/189,000                  $443,900/$246,950
Alan J. Hutchison               -              -                78,000/132,000                   $350,000/$140,000
Stephen R. Davis                -              -                 42,500/88,750                   $162,500/$162,500
- ------------------
</TABLE>

(a)  Difference  between  option  price and fair  market  value of the shares at
year-end.

                                       


                                       12
<PAGE>

Terms and Conditions of Certain Employment and Severance Agreements

         The  compensation  package for Harry H. Penner,  Jr., as President  and
Chief  Executive  Officer,  includes a salary  paid  pursuant  to an  employment
agreement  between Mr.  Penner and the Company which was entered into in October
1993. The agreement expired on November 30, 1997, but was automatically extended
for an additional  two-years pursuant to the terms of the agreement.  Under such
agreement,  Mr. Penner's base salary of $340,000 per annum in 1997 was increased
to  $357,000  effective  December 1, 1997.  Such  increase  was,  and any future
increases will be, at the  discretion of the Board of Directors.  The employment
agreement  restricts Mr. Penner from  competing with the Company for the term of
the agreement and for a period of one year after  termination  of his employment
with the Company.

         The  compensation  package  for  John F.  Tallman,  as  Executive  Vice
President and Scientific  Director of Neurogen,  includes a salary paid pursuant
to an employment agreement between Dr. Tallman and the Company which was entered
into in  June  1994.  The  agreement  expired  on  November  30,  1997,  but was
automatically  extended for an additional two-years pursuant to the terms of the
agreement. Under such agreement, Dr. Tallman's base salary of $215,000 per annum
in 1997 was increased to $226,000 effective December 1, 1997. Such increase was,
and any future  increases  will be, at the discretion of the Board of Directors.
The employment  agreement  restricts Dr. Tallman from competing with the Company
for the term of the agreement and for a period of one year after  termination of
his employment with the Company.

         The  compensation  package  for  Alan  J.  Hutchison,  as  Senior  Vice
President - Drug  Discovery  of Neurogen,  includes a salary paid  pursuant to a
two-year  renewable  employment  agreement between Dr. Hutchison and the Company
effective December 1, 1997. Under such agreement, Dr. Hutchison's base salary of
$193,500 per annum in 1997 was increased to $215,000 effective December 1, 1997.
Such increase was, and any future  increases  will be, at the  discretion of the
Board of  Directors.  The  employment  agreement  restricts Dr.  Hutchison  from
competing with the Company for the term of the agreement and for a period of one
year after termination of his employment with the Company.

         The compensation package for Stephen R. Davis, Vice President - Finance
and Chief  Financial  Officer of Neurogen,  includes a salary paid pursuant to a
two-year  renewable  employment  agreement  between  Mr.  Davis and the  Company
effective  December 1, 1997.  Under such  agreement,  Mr.  Davis' base salary of
$167,700 per annum in 1997 was increased to $180,000 effective December 1, 1997.
Such increase was, and any future  increases  will be, at the  discretion of the
Board of Directors.  The employment agreement restricts Mr. Davis from competing
with the  Company  for the term of the  agreement  and for a period  of one year
after termination of his employment with the Company.
                                      


                                       13
<PAGE>




                                                         
                               PERFORMANCE GRAPH1


         The  following  graph  compares the yearly  percentage in the Company's
cumulative  total  stockholder  return  on its  Common  Stock  during  a  period
commencing  on December  31, 1992 and ending  December  31, 1997 (as measured by
dividing  (i)  the  sum of (A)  the  cumulative  amount  of  dividends  for  the
measurement  period,  assuming  dividend  reinvestment,  and (B) the  difference
between the Company's share price at the end and the beginning of the period; by
(ii) the share at the beginning of the period) with the cumulative return of the
NASDAQ Stock Market Index (U.S. and Foreign) and the Amex  Biotechnology  Index.
It should be noted that Neurogen has not paid dividends on Common Stock,  and no
dividends are included in the representation of the Company's  performance.  The
stock price  performance  on the graph below is not  necessarily  indicative  of
future price performance.


                                                  NASDAQ                Amex
                          Neurogen             Total Market            Biotech

    12/31/92               100.0                   100.0                 100.0
    12/31/93                80.3                   115.8                  67.9
    12/31/94                78.8                   112.3                  48.1
    12/31/95               325.8                   157.7                  78.4
    12/31/96               233.3                   193.1                  84.6
    12/31/97               163.6                   236.3                  95.2












- ---------------------

         1 This Section is not "soliciting material," is not deemed "filed" with
the SEC and is not to be  incorporated by reference in any filing of the Company
under the  Securities  Act of 1933, as amended (the  "Securities  Act"),  or the
Exchange Act,  whether made before or after the date hereof and  irrespective of
any general incorporation language in any such filing.


                                      

                                       14
<PAGE>

                                 PROPOSAL NO. 1:

                   AMENDMENT OF 1993 OMNIBUS INCENTIVE PLAN TO
                  INCREASE SHARES OF COMMON STOCK RESERVED FOR
                                    ISSUANCE.


The maximum  number of shares of Common  Stock as to which awards may be granted
under the 1993 Omnibus  Incentive  Plan (the "Plan") as  originally  adopted was
limited to three million (3,000,000) shares. As of September 14, 1998 a total of
388,413  shares of Common Stock  remained  available for future grants under the
Plan.  Since the adoption of the Plan, the number of full time staff employed by
the  Company  has  approximately  tripled.  Each  full time  employee  typically
receives a grant of stock  options upon the  commencement  of  employment  and a
performance  based grant at the end of each fiscal  year.  In order to replenish
the Plan and provide for  sufficient  shares of Common Stock for future  grants,
the Board of Directors has approved  amending the Plan,  subject to  stockholder
approval,  to provide  that the number of shares of Common  Stock  reserved  for
issuance  under  the  Plan be  increased  by  adding  one and one  half  million
(1,500,000) new shares to the original three million (3,000,000) shares approved
upon  adoption of the Plan.  The Plan as so amended is hereby  submitted  to the
stockholders  of the Company for approval.  This  amendment is being proposed in
lieu of an earlier  proposal (the "Withdrawn  Proposal") made in connection with
Neurogen's May 1998 Annual Meeting of  Shareholders,  which was withdrawn by the
Board at the  recommendation  of management  prior to such Annual  Meeting.  The
Withdrawn  Proposal would have  increased the shares  available in the Plan by a
larger number than this proposal.  Neurogen management believes that the smaller
addition to the Plan  represented by this proposal will provide for more regular
shareholder oversight and assessment of company performance.


     THE BOARD OF DIRECTORS UNANIMOUSLY  RECOMMENDS A VOTE "FOR" THE ADOPTION OF
     THE AMENDMENT TO THE 1993 OMNIBUS  INCENTIVE PLAN ALLOWING FOR THE INCREASE
     OF SHARES OF COMMON STOCK RESERVED FOR ISSUANCE THEREUNDER.

     A general description of the basic features of the Plan is set forth below,
     Such description is qualified in its entirety by reference to the full text
     of the Plan which is set forth, as it is proposed to be amended hereby,  in
     full as Appendix A to this Proxy Statement.

     PURPOSE

     The purpose of the Plan is to further and promote the interests of Neurogen
     and its  stockholders  by  enabling  the  Company  to  attract,  retain and
     motivate  employees and  consultants or those who will become  employees or
     consultants,  and to  align  the  interests  of those  individuals  and the
     Company's  stockholders.  To do  this,  the Plan  offers  performance-based
     incentive  awards and  equity-based  opportunities  to provide such persons
     with a proprietary  interest in maximizing  the growth,  profitability  and
     overall success of the Company.

                                       15
<PAGE>


     NUMBER OF SHARES

     Under the Plan as initially adopted, the maximum number of shares of Common
     Stock as to which awards  could be granted was not to exceed three  million
     (3,000,000)  shares. The Board of Directors has approved amending the Plan,
     subject to  stockholder  approval,  to provide that the number of shares of
     Common Stock  reserved for issuance  under the Plan be increased by one and
     one half million  (1,500,000) shares from three million (3,000,000) to four
     and one half  million  (4,500,000)  shares.  During any calendar  year,  no
     individual may be granted stock options under the Plan to acquire more than
     one hundred  thousand  (100,000)  shares of Common Stock. The limits on the
     numbers of shares  described in this paragraph are subject to  proportional
     adjustment to reflect  certain stock changes,  such as stock  dividends and
     stock splits.

     If,  however,  any awards  expire or terminate  unexercised,  the shares of
     Common Stock  allocable to the  unexercised  or terminated  portion of such
     award shall again be  available  for awards under the Plan to the extent of
     such expiration or termination,  subject to certain  limitations  under the
     Plan.

     ADMINISTRATION

     The administration, interpretation and operation of the Plan will be vested
     in the Compensation  Committee.  Members of the Compensation Committee will
     serve at the pleasure of the Company's Board of Directors, which may at any
     time remove or add members to it. No member of the Compensation  Committee,
     nor any other director who is not a salaried  employee or consultant of the
     Company will be eligible to receive an award under the Plan.  The day-today
     administration of the Plan will be carried out by of officers and employees
     of the Company designated by the Compensation Committee.

     ELIGIBILITY

     All salaried employees  (including  officers and directors who are salaried
     employees)  and  consultants  of the Company are eligible to receive awards
     under the Plan.  Salaried employees who would be eligible to receive awards
     of stock options under the Plan would also be eligible to receive awards of
     Restricted  Shares.  Awards under the Plan will be made by the Compensation
     Committee or by an executive  officer who has been  delegated  authority to
     grant awards  pursuant to the Plan by the  Compensation  Committee.  Awards
     will be made pursuant to individual  award  agreements  between the Company
     and each participant.

     AWARDS UNDER THE PLAN

    Introduction.  Awards  under the Plan may  consist of stock  options,  stock
     appreciation rights,  restricted shares or performance unit awards, each of
     which is  described  below.  All awards will be  evidenced  by an agreement
     approved  by  the  Compensation   Committee.   In  the  discretion  of  the
     Compensation Committee, an eligible employee may receive awards from one or
     more of the  categories  described  below,  and more  than one award may be
     granted  to an  eligible  employee.  In  the  event  of any  change  in the
     outstanding  shares of Common  Stock of the  Company  by reason of  certain
     stock  changes,  including  without  limitation  stock  dividends and stock
     splits,  the terms of awards and number of shares of any outstanding  award
     may be equitably adjusted by the Board of Directors in its sole discretion.
     No  determination  has been made as to future  awards  which may be granted
     under the Plan,  although it is anticipated  that recipients of awards will
     include the current executive officers of the Company.

                                       16
<PAGE>
                                    
    Stock Options and Stock Appreciation Rights. A stock option is an award that
     entitles a participant to purchase  shares of Common Stock at a price fixed
     at the time the option is granted. Stock options granted under the Plan may
     be in the form of incentive  stock options  (which  qualify for special tax
     treatment),  non-qualified stock options or reload stock options and may be
     granted alone or in addition to other awards under the Plan.  Non-qualified
     stock  options may be granted  alone or in tandem  with stock  appreciation
     rights (SARs).
      
    SARs entitle a  participant  to receive,  upon  exercise,  cash,  restricted
     shares or  unrestricted  shares of Common Stock as provided in the relevant
     award agreement,  with a value equal to (a) the difference  between (i) the
     fair market value on the exercise  date of the shares with respect to which
     an SAR is exercised  and (ii) the fair market value on the date the SAR was
     granted,  multiplied  by (b) the number of shares of Common Stock for which
     the SAR has been exercised.  No SAR may be exercised until six months after
     its grant or prior to the  exercisability of the stock option with which it
     is granted in tandem, whichever is later.

    The exercise  price and other terms and  conditions  of such options will be
    determined by the  Compensation  Committee at the time of grant,  and in the
    case of incentive  stock  options and reload stock  options,  such  exercise
    price  will not be less than 100  percent  of the fair  market  value of the
    Common  Stock  on the  date of the  grant.  No term of any  incentive  stock
    options shall exceed ten years after grant. An option or SAR grant under the
    Plan does not  provide  an  optionee  any rights as a  shareholder  and such
    rights will accrue only as to shares actually purchased through the exercise
    of an option or the settlement of an SAR.

    Exercise  of an option (or an SAR) will  result in the  cancellation  of the
    related  SAR (or option) to the extent of the number of shares in respect of
    which such option or SAR has been exercised.  Unless otherwise determined by
    the  Compensation  Committee  or provided in the relevant  award  agreement,
    stock options shall become exercisable over a five year period from the date
    of grant  with 20%  vesting  on each  anniversary  of the grant in that time
    period.

    Payment for shares  issuable  pursuant  to the  exercise of an option may be
    made either in cash, by tendering either a fully-secured  promissory note or
    shares of Common Stock owned by a participant for at least six months with a
    fair  market  value at the date of  exercise  equal  to the  portion  of the
    exercise  price which is not paid in cash.  The  Compensation  Committee may
    also allow  participants to  simultaneously  exercise stock options and sell
    the  shares  of Common  Stock  acquired  thereby,  pursuant  to a  "cashless
    exercise" arrangement.

    Restricted Share Awards.  Restricted share awards are grants of Common Stock
    made to a participant subject to conditions  established by the Compensation
    Committee in the relevant award agreement. The restricted shares only become
    unrestricted in accordance with the conditions and vesting schedule, if any,
    provided in the relevant award  agreement,  but in no event shall restricted
    shares vest prior to six months after the date of grant.  A participant  may
    not sell or  otherwise  dispose of  restricted  stock  until the  conditions
    imposed by the Compensation Committee have been satisfied.  Restricted share
    awards  under  the Plan may be  granted  alone or in  addition  to any other
    awards  under the Plan.  Restricted  shares  which vest will be  reissued as
    unrestricted Common Stock.

    Each  participant  who receives a grant of  restricted  shares will have the
    right to receive all dividends and vote or execute  proxies for such shares.
    Any stock dividends will be treated as additional restricted shares.

                                       17
<PAGE>

    Performance Units. Performance units (with each unit representing a monetary
     amount  designated  in advance by the  Compensation  Committee)  are awards
     which may be grated to  employees  alone or in addition to any other awards
     under the Plan.  Participants  receiving  performance unit grants will only
     earn such units if the  Company  and/or  the  participant  achieve  certain
     performance goals during a designated  performance period. The Compensation
     Committee will establish such  performance  goals and may use such measures
     as total shareholder return,  return on equity, net earnings growth,  sales
     or revenue growth,  comparison to peer  companies,  individual or aggregate
     participant  performance or such other measures the Compensation  Committee
     deems appropriate.  The participant may forfeit such units in the event the
     performance goals are not met. If all or a portion of a performance unit is
     earned,  payment of the  designated  value thereof will be made in cash, in
     unrestricted   Common  Stock,   in  restricted   shares  or  in  discounted
     non-qualified stock options, as provided in the relevant award agreement.

    FORFEITURE UPON TERMINATION

    Unless  otherwise   provided  in  the  relevant  award  agreement  or  in  a
    participant's  then-effective  employment  or  consulting  agreement,  if  a
    participant's  employment is terminated  for any reason,  any  unexercisable
    stock  option or SAR shall be forfeited  and  canceled by the Company.  Such
    participant's  right to exercise  any  then-exercisable  stock option or SAR
    will terminate according to a schedule which provides for an exercise period
    which reflects the length of employment of the  participant  (but not beyond
    the  stated  term of such  stock  option  or SAR);  provided,  however,  the
    Committee  may  (to the  extent  options  were  exercisable  on the  date of
    termination)  extend such periods.  If a participant  dies,  becomes totally
    disabled  or  retires,  such  participant  (or the  estate  or  other  legal
    representative of the participant),  to the extent the stock options of SARs
    are exercisable  immediately prior to the date of death, total disability or
    retirement,  will be entitled to exercise  any stock  options or SARs for at
    least the two year period  following  such death,  disability or retirement,
    but not beyond the stated term of such stock option or SAR.

     Unless  otherwise  provided  in  the  relevant  award  agreement  or  in  a
     participant's  then-effective  employment  or  consulting  agreement,  if a
     participant's  employment is  terminated  for any reason (other than due to
     death,  total  disability  or  retirement)  (a) prior to the lapsing of any
     applicable   restriction   period,   or  the   satisfaction  of  any  other
     restrictions,  applicable to any grant of restricted  shares, or, (b) prior
     to the  completion  of any  performance  period in  respect of any grant of
     performance units, such restricted shares or performance units, as the case
     may be, will be forfeited by such participant;  provided, however, that the
     Compensation  Committee may, in its sole  discretion,  determine  within 90
     days after such termination that all or a portion of such restricted shares
     or performance units, as the case may be, shall not be so forfeited. In the
     case of death,  total  disability or retirement,  the  participant  (or the
     estate or other legal representatives of the participant) shall become 100%
     vested in any  restricted  shares as of the date of termination or shall be
     entitled to earn into the participant's performance units.

    CHANGE OF CONTROL

    If a Change of Control, as defined in the Plan, occurs (i) all Stock Options
    and/or SARs then  unexercised and  outstanding  will become fully vested and
    exercisable,  (ii) all  restrictions,  terms and  conditions  applicable  to
    restricted  shares then  outstanding will be deemed lapsed and satisfied and
    (iii) all performance  units will be deemed to have been fully earned,  each
    as of the date of the Change of Control; provided, however, that such Change
    of Control provisions will only apply to those participants who are employed
    by or  perform  consulting  services  for the  Company as of the date of the
    Change of Control.

                                       18
<PAGE>

    AMENDMENT, SUSPENSION OR TERMINATION OF THE PLAN

    The Board of  Directors  may amend,  suspend or  terminate  the Plan (or any
    portion thereof) at any time;  provided,  however,  that no amendment by the
    Board  of  Directors  may,  without  the  approval  of  a  majority  of  the
    stockholders, (i) increase the number of shares of Common Stock which may be
    issued under the Plan,  except as provided  therein,  (ii) materially modify
    the  requirements as to eligibility  for  participation  in the Plan,  (iii)
    materially  increase the benefits  accruing to  participants  under the Plan
    except as permitted  therein,  provided  Rule 16b-3 of the Exchange Act does
    not require shareholder approval. No amendment, suspension or termination by
    the Board of Directors shall (a) materially  adversely  affect the rights of
    any participant under any outstanding  share grants,  without the consent of
    such participant, or (b) make any change that would disqualify the Plan from
    the  exemption  provided  by Rule  165-3  of the  Exchange  Act or from  the
    benefits or  entitlements  to  deductions  provided  under  Sections 422 and
    162(m) of the Internal Revenue Code of 1986 (the "Code"), respectively.

     CERTAIN FEDERAL INCOME TAX CONSEQUENCES OF THE PLAN

    Incentive  Stock  Options.  Stock  options  granted  under  the  Plan may be
    incentive  stock options  (within the meaning of Section 422 of the Code) or
    non-qualified  stock options.  Upon the grant of an incentive  stock option,
    the optionee will not  recognize any income.  No income is recognized by the
    optionee  upon the  exercise  of an  incentive  stock  option if the holding
    period requirements contained in the Plan and in the Code are met, including
    the  requirement  that the optionee  remain an employee of the Company (or a
    subsidiary)  during the period  beginning  with the date of the grant of the
    option and ending on the day three months (one year if the optionee  becomes
    disabled)  before  the date the  option  is  exercised.  The  optionee  must
    increase his or her alternative  minimum taxable income for the taxable year
    in which he or she exercised  the incentive  stock option by the amount that
    would have been ordinary  income had the option not been an incentive  stock
    option.

    Upon the subsequent  disposition of shares  acquired upon the exercise of an
    incentive stock option, the federal income tax consequences will depend upon
    when the disposition  occurs and the type of disposition.  If the shares are
    disposed of by the optionee after the end of the one-year  period  beginning
    on the day after the day the shares are issued to the optionee,  any gain or
    loss realized upon such disposition will be long-term  capital gain or loss,
    and the  Company  (or a  subsidiary)  will not be entitled to any income tax
    deduction  in  respect  of the  option  or its  exercise.  For  purposes  of
    determining the amount of such gain or loss, the optionee's tax basis in the
    shares will be the option price.

    Generally,  if the  shares  are  disposed  of by the  optionee  in a taxable
    disposition  within the one-year  period  beginning on the day after the day
    the shares are issued to the  optionee,  the  excess,  if any, of the amount
    realized (up to the fair market  value of the shares on the  exercise  date)
    over the  option  price will be  compensation  taxable  to the  optionee  as
    ordinary income, and the Company will be entitled to a deduction (subject to
    the  provisions  of Section  162(m) of the Code  discussed  below  under the
    caption  "Limits  on  Deductions")  equal to the amount of  ordinary  income
    realized by the optionee.

    If an optionee has not remained an employee of the Company during the period
    beginning with the grant of an incentive  stock option and ending on the day
    three months (one year if the optionee becomes disabled) before the date the
    option is  exercised,  the  exercise  of such  option will be treated as the
    exercise of a non-qualified stock option with the tax consequences described
    below.

                                       19
<PAGE>

    Non-Qualified Stock Options. Upon the grant of a non-qualified stock option,
    an  optionee  will not  recognize  any income.  At the time a  non-qualified
    option is exercised,  the optionee will  recognize  compensation  taxable as
    ordinary income, and the Company will be entitled to a deduction (subject to
    the  provisions  of Section  162(m) of the Code  discussed  below  under the
    caption  "Limits  on  Deductions"),  in an  amount  equal to the  difference
    between the fair market  value on the exercise  date of the shares  acquired
    pursuant  to  such  exercise  and  the  option  price.   Upon  a  subsequent
    disposition of the shares,  the optionee will recognize  long- or short-term
    capital gain or loss,  depending upon the holding period of the shares.  For
    purposes of determining  the amount of such gain or loss, the optionee's tax
    basis in the  shares  will be the fair  market  value of such  shares on the
    exercise date.

    Effect of Share-for-Share  Exercise.  If an optionee elects to tender shares
    of Common Stock in partial or full payment of the option price for shares to
    be acquired  through the exercise of an option,  generally the optionee will
    not  recognize  any gain or loss on such tendered  shares.  However,  if the
    shares  tendered  in  connection  with  any  share-for-share  exercise  were
    previously acquired upon the exercise of an incentive stock option, and such
    share-for-share  exercise  occurs within one year after the tendered  shares
    were  transferred  to the  optionee,  the  tender of such  shares  will be a
    taxable  disposition  with  the tax  consequences  described  above  for the
    taxable  disposition within one year of shares acquired upon the exercise of
    an incentive stock option.

    If the  optionee  tenders  shares upon the exercise of an option which would
    result in the receipt of  compensation  by the optionee,  as described above
    under the caption "Non-Qualified Stock Options", the optionee will recognize
    compensation  taxable as ordinary income and the Company will be entitled to
    a  deduction  (subject  to the  provisions  of  Section  162(m)  of the Code
    discussed below under the caption "Limits on Deductions") in an amount equal
    only to the fair  market  value of the  number  of  shares  received  by the
    optionee upon exercise which is in excess of the number of tendered  shares,
    less any cash paid by the optionee.

    Limits on  Deductions.  Under  Section  162(m) of the  Code,  the  amount of
    compensation  paid to the chief  executive  officer  and the four other most
    highly  paid  executive  officers  of the  Company  in the year for  which a
    deduction is claimed by the Company  (including its subsidiaries) is limited
    to  $1,000,000  per person in any year,  except that  compensation  which is
    performance-based will be excluded for purposes of calculating the amount of
    compensation  subject  to this  $1,000,000  limitation.  The  ability of the
    Company to claim a deduction for  compensation  paid to any other  executive
    officer or employee  of the  Company  (including  its  subsidiaries)  is not
    affected by this provision.

    The Company has structured the Plan so that any  compensation  for which the
    Company  may  claim  a  deduction  in   connection   with  the  exercise  of
    non-qualified  stock  options and  related  SARs and the  disposition  by an
    optionee of shares  acquired  upon the exercise of incentive  stock  options
    will be  performance-based  within the  meaning  of Section  162(m) of Code.
    Because  the  restricted  share  awards  under the Plan are not deemed to be
    performance-based  under Section  162(m) of the Code,  amounts for which the
    Company may claim a  deduction  upon the lapse of any  restrictions  on such
    restricted  share awards will be subject to the limitations on deductibility
    under Section 162(m).

                                       20
<PAGE>

    Additional Information. Unless an appropriate election is made under Section
    83(b) of the Code to include  amounts  in income  currently,  under  Section
    83(c)(3) of the Code an employee who is an officer of the Company subject to
    Section 16(b) of the Exchange Act will not, in certain instances,  recognize
    any income upon the satisfaction of the terms and conditions applicable to a
    restricted  stock  unit,  if the  sale  of the  shares  received  upon  such
    satisfaction  could subject the employee to liability under Section 16(b) of
    the Exchange Act Regulations  issued by the Internal Revenue Service provide
    that in such a situation income will be recognized not later than six months
    after such  satisfaction,  even though a sale of such shares after that time
    could still subject the employee to suit under Section 16(b).  In connection
    with any of such events,  the Company is not  entitled to a deduction  until
    the date the employee recognizes income with respect to such event.

    The  recognition  by an employee of  compensation  income with  respect to a
    grant or an award under the Plan will be subject to withholding  for federal
    income and employment tax purposes.  If an employee, to the extent permitted
    by the terms of a grant or award under the Plan, uses shares of Common Stock
    to satisfy the federal income and employment tax withholding obligation,  or
    any similar withholding obligation for state and local tax obligations,  the
    employee  will  recognize a capital gain or loss,  short-term  or long-term,
    depending  on the tax basis and  holding  period  for such  shares of Common
    Stock.

    If the  provisions  of the Plan  relating  to a  change  in  control  become
    applicable,  certain  compensation  payments or other  benefits  received by
    "disqualified individuals" (as defined in Section 280G(c) of the Code) under
    the Plan or otherwise may cause or result in "excess parachute payments" (as
    defined  in  Section  280G(b)(I)  of the  code).  Section  4999 of the  code
    generally  imposes  a 20%  excise  tax on the  amount  of  any  such  excess
    parachute payment received by such a disqualified  individual,  and any such
    excess  parachute  payments  will not be  deductible  by the  Company  (or a
    subsidiary).  In  addition,  certain  disqualified  individuals  may receive
    reimbursement  payments from the Company to eliminate the adverse  effect of
    such 20% excise tax

    Any such reimbursement payments will be compensation income to the recipient
    subject to additional income and excise taxation, but will not be deductible
    by the Company (or any subsidiary).
                                                  * * * * *

    At September 15, 1998 the total number of outstanding shares of Common Stock
    was 14,429,832  shares.  The closing price of the Common Stock on the NASDAQ
    National Market on September 15, 1998 was $12.25 per share.


    EFFECTIVE DATE

    The Plan became  effective on December 30, 1993, the date of its adoption by
    the Board of Directors. The Plan will terminate on December 21, 2003, except
    with respect to awards then  outstanding.  After such date no further awards
    will be granted  under the Plan  unless the Plan is extended by the Board of
    Directors.


                                       21
<PAGE>

    APPROVAL OF THE PROPOSED AMENDMENT TO THE PLAN

    To become effective,  the Proposed Amendment to the Plan must be approved by
    the  affirmative  vote of a majority of the votes cast at the Annual Meeting
    on this  proposal by the holders of the shares of Common  Stock  entitled to
    vote thereat.

    The Board of Directors recommends that the stockholders vote FOR approval of
    this  proposal.  If not  otherwise  specified,  proxies  will be  voted  FOR
    approval.

                                       22
<PAGE>


                     SHAREHOLDER PROPOSALS AND OTHER MATTERS

         The Board of Directors of the Company  knows of no other  matters to be
submitted to the Special Meeting.  If any other matters properly come before the
Special  Meeting,  it is the intention of the persons named in the enclosed form
of proxy to vote the  shares  of Common  Stock  they  represent  as the Board of
Directors may  recommend.  Anyone  desiring to address the  stockholders  at the
Special Meeting,  whether or not making a formal proposal, must so indicate this
intention to the Secretary of the Company prior to the Special Meeting.



         In order to be considered for inclusion in the Proxy Statement and form
of proxy relating to the 1999 Annual Meeting of Stockholders,  any proposal by a
stockholder  of record of the  Company  must be  received  by the Company at its
principal executive offices in Branford,  Connecticut, on or before December 20,
1998.

         THE COMPANY WILL MAIL WITHOUT CHARGE,  TO EACH STOCKHOLDER  ENTITLED TO
VOTE AT THE SPECIAL MEETING UPON WRITTEN REQUEST, A COPY OF THE COMPANY'S ANNUAL
REPORT ON FORM 10-K, INCLUDING THE FINANCIAL STATEMENTS, SCHEDULES AND A LIST OF
EXHIBITS, AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION. WRITTEN REQUESTS
SHOULD BE SENT TO:  CORPORATE  SECRETARY,  NEUROGEN  CORPORATION,  35  NORTHEAST
INDUSTRIAL ROAD, BRANFORD, CONNECTICUT 06405


                                                                 JOHN F. TALLMAN
                                                                 Secretary

October 8, 1998









                                       23

<PAGE>


                                   APPENDIX A


                              NEUROGEN CORPORATION
                     1993 OMNIBUS INCENTIVE PLAN, AS AMENDED



         1.  PURPOSE.  The  purpose  of the 1993  Omnibus  Incentive  Plan is to
further and promote the interests of  Neurogen  Corporation,   its  Subsidiaries
and its  shareholders by  enabling the  Company and its Subsidiaries to attract,
retain  and  motivate   employees  and   consultants  or those  who will  become
employees or consultants,   and to align the  interests of those individuals and
the  Company's  shareholders.   To do this,   the Plan offers  performance-based
incentive awards and  equity-based opportunities  to provide such persons with a
proprietary  interest  in  maximizing  the  growth,   profitability  and overall
success of the Company and its Subsidiaries.

         2.  DEFINITIONS.  For purposes of the Plan,  the following  terms shall
have the meanings setforth below:

                    2.1    "Award" means an award or grant made to a Participant
under Sections 6, 7, 8 and/or 9 of the Plan.

                    2.2 "Award  Agreement"  means the  agreement  executed  by a
Participant  pursuant to Sections 3.2 and 17.7  of the Plan in  connection  with
the granting of an Award.

                    2.3    "Board" means the Board of Directors of the  Company,
as constituted from time to time.

                    2.4 "Change of Control" means (i) any individual,  entity or
group (within the meaning of Section 13(d)(3)  or 14(d)(2) of the  Exchange Act)
acquires,   as  a  result  of   any  purchase  or  exchange,    or  any  merger,
consolidation or other   reorganization,  a majority of the  outstanding  voting
securities  or  assets  of the  Company   or (ii) the  Board   or the  Company's
shareholders,  either or both,  as may be required to authorize the same, shall
approve  any  liquidation  or   dissolution  of the  Company  or  sale of all or
substantially all of the assets of the Company.

                    2.5 "Code"  means the Internal  Revenue Code of 1986,  as in
effect and as amended from time to time,   or any  successor  statute   thereto,
together  with  any  rules,    regulations  and   interpretations    promulgated
thereunder or with respect thereto.

                    2.6    "Committee"  means the committee of the Board 
described in Section 3 the of the Plan.

                    2.7 "Common  Stock" means the Common Stock,  par value $.025
per share, of the Company or any security  of the Company issued by the  Company
in substitution or exchange therefor.

                    2.8  "Company"  means  Neurogen   Corporation,   a  Delaware
corporation, or any successor corporation to Neurogen Corporation.

                                       24
<PAGE>

                    2.9   "Disability"   means  disability  as  defined  in  the
Participant's then effective  employment  or consulting  agreement,   or if the
participant  is not then  a party to  an  effective  employment  or  consulting
agreement  with the Company  which  defines   disability,   "Disability"  means
disability as determined  by the  Committee  in accordance  with  standards and
procedures similar to those  under the  Company's long-term disability plan, if
any.  Subject to the first  sentence of this Section 2.9,  at any  time that the
Company does not maintain a long-term   disability  plan,   "Disability"  shall
mean any physical or  mental  disability  which is  determined  to be total and
permanent by a physician selected in good faith by the Company.

                    2.10  "Exchange  Act" means the  Securities  Exchange Act of
1934, as in effect and as amended from time to time,   or any successor  statute
thereto,  together with any rules,  regulations and  interpretations promulgated
thereunder or with respect thereto.

                    2.11  "Execution  Date" has the meaning set forth in Section
14.3.1 of the Plan.

                    2.12 "Fair  Market  Value" means on, or with respect to, any
given  date(s),  the  closing price for the Common  Stock,   as reported on  the
NASDAQ National Market for such  date(s) or,  if the Common Stock was not traded
on such  date(s),   on the next preceding day  or days on which the Common Stock
was  traded.  If at any  time the Common  Stock  is not  traded   on the  NASDAQ
National Market,  the Fair Market Value of a share of the  Common Stock shall be
determined in good faith by the Board.

                    2.13 "Incentive Stock Option" means any stock option granted
pursuant to the  provisions  of Section  6 of the Plan  (and the  relevant Award
Agreement)  that  is  intended  to be  (and is  specifically  designated as)  an
"incentive stock option" within the meaning of Section 422 of the Code.

                    2.14  "Merger  Event" has the  meaning  set forth in Section
14.3.1 of the Plan.

                    2.15  "Non-Qualified  Stock  Option"  means any stock option
granted  pursuant to the provisions of Section 6  of the Plan  (and the relevant
Award  Agreement)  that is not  (and is specifically designated as not being) an
Incentive Stock Option.

                    2.16 "Participant" means any individual who is selected from
time to time under Section 5 to receive an Award under the Plan.

                    2.17   "Performance Goals"  has  the  meaning  set  forth in
Section 9.4 of the Plan.

                    2.18    "Performance Period"  has the meaning set  forth  in
Section 9.4 of the Plan.

                    2.19  "Performance  Units" means the monetary  units granted
under Section 9 of the Plan and the relevant Award Agreement.

                    2.20 "Plan"  means the  Neurogen  Corporation  1993  Omnibus
Incentive Plan,  as set forth herein and as in effect and as  amended from  time
to time (together with any rules  and  regulations  promulgated by the Committee
with respect thereto).

                                       25
<PAGE>

                    2.21 "Reload  Stock Option"  means any  Non-Qualified  Stock
Option  automatically granted pursuant to the  provisions of Section 6.7  of the
Plan and the relevant Award Agreement.

                    2.22  "Restricted  Shares"  means the  restricted  shares of
Common Stock  granted  pursuant to the  provisions of  Section 8 of the Plan and
the relevant Award Agreement.
                                    
                    2.23   "Restriction  Period"  has  the  meaning set forth in
Section 8.3 of the Plan.

                    2.24  "Retirement"  means the  voluntary  retirement  by the
Participant from active employment with the  Company and its Subsidiaries  on or
after the attainment of sixty-five (65).

                    2.25    "SEC" means the Securities and Exchange Commission, 
or any successor governmental agency.

                    2.26 "SEC Rule 16b-3" means Rule 16b-3,  as  promulgated  by
the SEC under  Section  16(b) of the  Exchange  Act,  or any  successor  rule or
regulation thereto,  as such Rule is amended or applied from time to time.

                    2.27 "Stock  Appreciation Right" means an Award described in
Section 7.2 of the Plan and granted  pursuant to the  provisions of Section 7 of
the Plan.

                   2.28 "Subsidiary(ies)"  means any corporation (other than the
Company) in an unbroken chain of corporations,  including and beginning with the
Company,   if each of such corporations,  other than the last corporation in the
unbroken chain, owns,  directly or indirectly,  more than fifty percent (50%) of
the voting stock in one of the other corporations in such chain.

          3.  ADMINISTRATION

                   3.1 The  Committee.  The Plan  shall be  administered  by the
Committee.  The Committee shall be appointed from time to  time by the Board and
shall be  comprised of not less than three (3) of the then  members of the Board
all of whom qualify to administer  the Plan as   "disinterested  administrators"
within  the  meaning of SEC Rule 16b-3 and as   "outside  directors"  within the
meaning of Code Section 162(m).  No member of the Committee shall be eligible to
receive  awards  under the Plan.  Consistent   with the By-Laws of the  Company,
members  of the  Committee  shall  serve at the   pleasure  of the Board and the
Board, subject to the immediately  preceding sentence,  may at any time and from
time to time remove members from, or add members to, the Committee.

                                       26
<PAGE>

                   3.2 Plan  Administration  and Plan Rules.  The  Committee  is
authorized  to construe and  interpret  the Plan and to  promulgate,   amend and
rescind rules and regulations  relating to the  implementation,   administration
and  maintenance of the Plan.  Subject to the terms and  conditions of the Plan,
the  Committee  shall make all  determinations  necessary or  advisable  for the
implementation,  administration and  maintenance of the Plan including,  without
limitation,   (a) selecting the Participants,  (b) making Awards in such amounts
and form as the Committee  shall  determine,  (c)  imposing  such  restrictions,
terms and conditions upon such Awards as the Committee  shall deem  appropriate
and (d)  correcting  any  technical   defect(s)  or  technical  omission(s),  or
reconciling  any  technical  inconsistency(ies),   in the Plan  and/or any Award
Agreement.  The  Committee  may   designate  persons  other than  members of the
Committee to carry out the day-to-day  ministerial   administration  of the Plan
under such conditions and  limitations as it may prescribe.   Except as provided
in the  immediately  following  sentence,  the Committee  shall not delegate its
authority with regard to the selection for  participation in the Plan and/or the
granting of any Awards to  Participant.  The  Committee may  (i) delegate to the
Company's  President and Chief  Executive  Officer and  a Vice  President of the
Company, as designated by the Committee,  the authority to grant Awards to those
eligible  employees  and  consultants  who  are not subject to Section 16 of the
Exchange Act or (ii) adopt a  resolution to automatically provide to an employee
or consultant  upon the initial  employment or   performance of services of such
person a grant of an Award:   provided  however such delegation or adoption will
not be  effective  if it would  disqualify  the Plan,   or any other plan of the
Company or any Subsidiary  intended to be so qualified,   from (i) the exemption
provided by SEC Rule 16b-3,  (ii) the benefits provided under Section 422 of the
Code, or any successor  provisions  thereto or (iii)   entitlement to deductions
under Code Section 162(m),  or any successor provision thereto.  The Committee's
determinations  under the Plan need  not be uniform and may be made  selectively
among  Participants,   whether or not such Participants are similarly  situated.
Any  determination,   decision or action of the Committee in connection with the
construction, interpretation,   administration, implementation or maintenance of
the Plan shall be final,   conclusive and binding upon all  Participants and any
person(s) claiming under or through any Participants.   The Company shall effect
the granting of Awards under the Plan,   in accordance  with the  determinations
made  by the  Committee,   by  execution  of  written  agreements  and/or  other
instruments in such form as is approved by the Committee.

                   3.3  Liability  Limitation  .  Neither  the  Board,  nor  the
Committee  attorneys,  nor any member of  either,   shall be liable for any act,
omission,  interpretation,  construction or determination  made in good faith in
connection with the Plan (or any Award Agreement),  and the members of the Board
and the Committee shall be entitled to indemnification  and reimbursement by the
Company in respect of any claim,  loss, damage or expense   (including,  without
limitation,  attorneys'   fees)  arising or  resulting  therefrom to the fullest
extent  permitted  by law,   the  Company's  Certificate  of  Incorporation,  as
amended,  and/or under any directors and officers  liability  insurance coverage
which may be in effect from time to time.

                                       27
<PAGE>

          4.  TERM OF PLAN/COMMON STOCK SUBJECT TO PLAN

                   4.1 Term.  The Plan shall  terminate  on December  21,  2003,
except  with  respect  to Awards  then  outstanding.  After such date no further
Awards shall be granted under the Plan unless the Plan is extended by the Board.

                    4.2 Common  Stock.  The  maximum  number of shares of Common
Stock in  respect  of which  Awards  may be  granted or paid out under the Plan,
subject to  adjustment  as  provided  in Section  14.2 of  the Plan,  shall  not
exceed four million five  hundred thousand, (4,500,000) shares.  In the event of
a change in the Common Stock of the  Company that is limited to a change in the
designation  thereof to "Capital Stock" or other  similar  designation,  or to a
change in the par  value  thereof,  or from par value to  no par value,  without
increase or decrease in the number  of issued shares, the shares  resulting from
any such  change  shall  be deemed to be the Common  Stock  for  purposes of the
Plan. Common Stock which may be issued under the  Plan may  be either authorized
and unissued shares or issued shares  which have  been reacquired by the Company
(in the  open-market  or in private  transactions)  and which are  being held as
treasury  shares.  No  fractional  shares of Common Stock shall  be issued under
the Plan.

                    4.3  Computation  of  Available  Shares.  For the purpose of
computing the total number of shares of Common Stock  available for Awards under
the Plan,  there shall be counted  against the  limitations set forth in Section
4.2 of the Plan the maximum number of shares of Common Stock potentially subject
to issuance upon exercise or settlement of Awards granted under Sections 6 and 7
of the  Plan,  the  number of shares of  Common  Stock  issued  under  grants of
Restricted  Shares  pursuant to Section 8 of the Plan and the maximum  number of
shares of  Common  Stock  potentially  issuable  under  grants  or  payments  of
Performance  Units pursuant to Section 9 of the Plan, in each case determined as
of the date on which such Awards are granted.  If any Awards expire  unexercised
or are forfeited,  surrendered,  canceled, terminated or settled in cash in lieu
of Common Stock, the shares of Common Stock which were  theretofore  subject (or
potentially  subject) to such Awards shall again be  available  for Awards under
the Plan to the extent of such expiration,  forfeiture, surrender, cancellation,
termination or settlement of such Awards;  provided however, that such forfeited
Awards shall not again be available for Awards under the Plan if the Participant
received,  directly  or  indirectly,  any of the  benefits of  ownership  of the
securities of the Company underlying such Award, including,  without limitation,
the right to receive dividend or dividend equivalent  payments,  as described in
Sections 8.5 and 11 of the Plan.

         5.  ELIGIBILITY.  Individuals  eligible for Awards under the Plan shall
consist of all salaried employees,  or those who will become salaried employees,
of the Company and/or its Subsidiaries and consultants of the Company and/or its
Subsidiaries.

                                       28
<PAGE>

         6.  STOCK OPTIONS

                     6.1 Terms and  Conditions.  Stock Options granted under the
Plan shall be in respect of Common  Stock and  may be in the  form of  Incentive
Stock Options,  Non-Qualified Stock  Options or Reload Stock Options  (sometimes
referred to collectively herein as the  "Stock Option(s))".   Such Stock Options
shall be subject to the terms and   conditions  set forth in  this Section 6 and
any additional terms and conditions,   not inconsistent  with  the express terms
and  provisions of the Plan, as the Committee  shall  set forth  in the relevant
Award Agreement.

                    6.2 Grant.  Stock  Options may be granted  under the Plan in
such form as the Committee may from time to time approve.   Stock Options may be
granted  alone or in addition to other   Awards under the Plan or in tandem with
Stock  Appreciation  Rights.  Incentive   Stock  Options  may only be granted to
employees of the Company and/or its Subsidiaries.  Notwithstanding the above, no
Incentive  Stock  Options shall be  granted to any employee who owns (within the
meaning of Section  422(b)(6)  of the Code)  more than ten percent  (10%) of the
total  combined  voting  power of all  classes   of stock of the  Company or its
parent  corporation  or any   subsidiary  of the Company  (within the meaning of
Sections  424(e) and (f) of the Code).   During any calendar year, no individual
may be granted  under the Plan Stock  Options  to acquire  more than one hundred
thousand (100,000) shares of Common Stock.

                   6.3 Exercise  Price.  The exercise  price per share of Common
Stock  subject  to a  Stock  Option  shall  be  determined  by   the  Committee,
including,  without limitation a determination based on a formula  determined by
the Committee; provided, however, that the exercise price of an Incentive  Stock
Option or a Reload  Stock  Option  shall not be less than one  hundred   percent
(100%) of the Fair Market Value of the Common Stock on the date  of the grant of
such Incentive Stock Option or Reload Stock Option.

                   6.4 Term.  The term of each Stock Option shall be such period
of time as is fixed by the Committee;  provided,   however, that the term of any
Incentive  Stock  Option  shall  not   exceed  ten  (10)  years  after  the date
immediately preceding the date on  which the  Incentive Stock Option is granted.

                   6.5 Method of Exercise.  A Stock Option may be exercised,  in
whole or in part, by giving  written notice  of exercise to the Secretary of the
Company,  or the  Secretary's  designee,  specifying the  number of shares to be
purchased.  Such notice shall be accompanied  by payment in full of the exercise
price in cash,  by certified  check,   bank draft or money order  payable to the
order of the Company or, if permitted by the Committee  (in its sole discretion)
and applicable law, by delivery of, alone or in conjunction with a  partial cash
or instrument payment, (a) a fully-secured  promissory note or notes, (b) shares
of Common Stock already owned by the Participant for at least  six (6) months or
(c) any other form of payment  acceptable to the  Committee.   The Committee may
also  permit   Participants    (either  on  a  selective   or  group  basis)  to
simultaneously  exercise  Stock  Options  and sell  the  shares of Common  Stock
thereby  acquired,  pursuant to a  "cashless  exercise"  arrangement or program,
selected  by and  approved  of in all  respects  in  advance  by the  Committee.
Payment instruments shall be received by the Company subject to  collection. The
proceeds  received by the Company upon  exercise of any Stock Option may be used
by the Company for general  corporate  purposes.  Any portion  of a Stock Option
that is exercised may not be exercised again.

                                       29
<PAGE>

                   6.6  Exercisability.  In respect of any Stock Option  granted
under the Plan,  unless  otherwise (a)  determined by the Committee (in its sole
discretion)  at any time and from  time to time  in  respect  of any such  Stock
Option  or  (b)  provided  in  the  Award  Agreement  or  in  the  Participant's
employment  or consulting  agreement  in respect of any such Stock Option,  such
Stock Option shall become  exercisable as to the  aggregate  number of shares of
Common Stock underlying such Stock Option,   as determined on the date of grant,
as follows:

                    20%,  on the first  anniversary  of the date of grant of the
                    Stock Option,  provided the  Participant is then employed by
                    or providing  consulting services for the Company and/or one
                    of its Subsidiaries;

                    40%, on the second  anniversary  of the date of grant of the
                    Stock Option,  provided the  Participant is then employed by
                    or providing  consulting services for the Company and/or one
                    of its Subsidiaries;

                    60%,  on the third  anniversary  of the date of grant of the
                    Stock Option,  provided the  Participant is then employed by
                    or providing  consulting services for the Company and/or one
                    of its Subsidiaries;

                    80%, on the fourth  anniversary  of the date of grant of the
                    Stock Option,  provided the  Participant is then employed by
                    or providing  consulting services for the Company and/or one
                    of its Subsidiaries; and

                    100%, on the fifth  anniversary  of the date of grant of the
                    Stock Option,  provided the  Participant is then employed by
                    or providing  consulting services for the Company and/or one
                    of its Subsidiaries.

Notwithstanding  anything to the   contrary  contained  in this Section 6.6 such
Stock Option  shall become one hundred   percent  (100%)  exercisable  as to the
aggregate  number of shares of Common Stock  underlying   such Stock Option upon
the death, Disability or Retirement of the Participant.

                   6.7 Reload  Stock  Options.  The  Committee  may, in its sole
discretion,  provide in any Award  Agreement   in  respect of any  Non-Qualified
Stock Option that if the Participant  delivers  shares of the  Company's  Common
Stock already owned by such  Participant for at least six (6)  months in full or
partial payment of the exercise price of such  Non-Qualified  Stock Option,  the
Participant  shall   automatically  (subject  to the  limitations  contained  in
Section  4.2) and  immediately  thereupon  be granted  a Reload  Stock Option to
purchase that number of  shares of Common Stock  delivered by the Participant to
the  Company   (on such  terms  as the  Committee  may  prescribe  under  and in
accordance with the Plan).

                   6.8 Tandem Grants.  If Non-Qualified  Stock Options and Stock
Appreciation  Rights are granted in tandem,  as designated in the relevant Award
Agreements, the right of a  Participant to exercise any such tandem Stock Option
shall  terminate to the extent that the shares of Common Stock  subject to such
Stock  Option  are used to  calculate   amounts  or shares  receivable  upon the
exercise of the related tandem Stock Appreciation Right.

                                       30
<PAGE>
          7.  STOCK APPRECIATION RIGHTS

                   7.1 Terms  and  Conditions.  The grant of Stock  Appreciation
Rights under the Plan shall be subject to  the terms and conditions set forth in
this Section 7 and any additional terms and conditions,   not inconsistent  with
the express terms and provisions of the Plan, as the Committee   shall set forth
in the relevant Award Agreement.

                   7.2 Stock Appreciation  Rights. A Stock Appreciation Right is
an Award  granted with respect to a specified  number of shares of  Common Stock
entitling a  Participant  to receive an amount  equal to  the excess of the Fair
Market Value of a share of Common  Stock on the date of  exercise  over the Fair
Market  Value of a share  of  Common  Stock  on the date of grant  of the  Stock
Appreciation  Right,  multiplied  by the number of shares of Common  Stock  with
respect to which the Stock Appreciation Right shall have been exercised.

                   7.3  Grant.  A Stock  Appreciation  Right may be  granted  in
addition to any other Award under the Plan or in tandem with or   independent of
a  Non-Qualified  Stock Option.  During any calendar year, no individual  may be
granted under the Plan Stock Appreciation  Rights with respect to more than  one
hundred thousand (100,000) shares of Common Stock.

                   7.4 Date of Exercisability.  Unless otherwise provided in the
Participant's employment agreement,  consulting agreement or Award Agreement  in
respect of any Stock  Appreciation  Right,   a Stock  Appreciation  Right may be
exercised  by a  Participant,   in  accordance  with and  subject  to all of the
procedures  established by the  Committee,   in whole or in part at any time and
from time to time during its  specified  term.   Notwithstanding  the  preceding
sentence,  in no event shall a Stock Appreciation Right  be exercisable prior to
the date which is six (6) months after the date on which the Stock  Appreciation
Right was granted or prior to the  exercisabi1ity  of any   Non-Qualified  Stock
Option with which it is granted in tandem.  The Committee may also  provide,  as
set forth in the relevant  Award  Agreement and without  limitation,  that some
Stock Appreciation  Rights shall be automatically  exercised and  settled on one
or more fixed dates specified therein by the Committee.

                   7.5 Form of Payment.  Upon  exercise of a Stock  Appreciation
Right,  payment  may be made in cash,   in  Restricted  Shares  or in  shares of
unrestricted Common Stock, or in any combination thereof,  as the Committee,  in
its  sole  discretion,  shall  determine  and  provide  in the   relevant  Award
Agreement.

                   7.6 Tandem Grant.  The right of a  Participant  to exercise a
tandem Stock Appreciation Right shall terminate  to the extent  such Participant
exercises  the  Non-Qualified  Stock  Option to  which such  Stock  Appreciation
Right is related.

          8.  RESTRICTED SHARES

                   8.1 Terms and Conditions.  Grants of Restricted  Shares shall
be subject  to the terms and   conditions  set forth  in this  Section 8 and any
additional terms and  conditions,   not inconsistent  with the express terms and
provisions of the Plan, as the Committee  shall set forth in  the relevant Award
Agreement.  Restricted  Shares may be granted  alone or in addition to any other
Awards under the Plan.  Subject to  the terms of the Plan,  the Committee  shall
determine the number of Restricted  Shares  to be granted to a  Participant  and
the  Committee  may provide or  impose  different  terms  and  conditions on any
particular  Restricted  Share grant made to  any  Participant.   With respect to
each  Participant  receiving  an Award  of  Restricted  Shares,   there shall be
issued a stock   certificate  (or  certificates)  in  respect of such Restricted
Shares.  Such stock   certificate(s)  shall be  registered   in the name of such
Participant,   shall be  accompanied  by  a stock  power duly  executed  by such
Participant,  and shall bear,   among other  required  legends,   the  following
legend:
                                       31
<PAGE>

                              "The  transferability  of this certificate and the
                    shares of stock represented  hereby are subject to the terms
                    and conditions  (including,  without limitation,  forfeiture
                    events)  contained in the Neurogen  Corporation 1993 Omnibus
                    Incentive Plan and an Award  Agreement  entered into between
                    the registered owner hereof and Neurogen Corporation. Copies
                    of such Plan and Award  Agreement  are on file in the office
                    of  the   Secretary  of  Neurogen   Corporation,   Branford,
                    Connecticut.   Neurogen  Corporation  will  furnish  to  the
                    recordholder  of the  certificate,  without  charge and upon
                    written request at its principal  place of business,  a copy
                    of such  Plan  and  Award  Agreement.  Neurogen  Corporation
                    reserves  the right to refuse to record the transfer of this
                    certificate until all such  restrictions are satisfied,  all
                    such terms are  complied  with and all such  conditions  are
                    satisfied."

Such stock  certificate  evidencing such shares shall, in the sole discretion of
the  Committee,  be deposited  with and held in custody by the Company until the
restrictions  thereon  shall  have  lapsed  and all of the terms and  conditions
applicable to such grant shall have been satisfied.

                    8.2 Restricted Share Grants. A grant of Restricted Shares is
an Award of shares of Common Stock granted to  a  Participant,   subject to such
restrictions,  terms  and  conditions  as   the  Committee  deems   appropriate,
including,  without  limitation,  (a)  restrictions  on  the sale,   assignment,
transfer,    hypothecation  or  other  disposition  of  such  shares,   (b)  the
requirement  that the  Participant  deposit such  shares with  the Company while
such shares are subject to such restrictions and  (c)  the requirement that such
shares be forfeited upon  termination of  employment or consulting  services for
specified  reasons   within  a  specified  period of time or for  other  reasons
(including,  without limitation, the failure to  achieve designated  performance
goals).

                    8.3  Restriction  Period In accordance with Sections 8.1 and
8.2 of the Plan and unless otherwise  determined by  the Committee  (in its sole
discretion)  at any time and  from time to time,   Restricted  Shares shall only
become  unrestricted  and vested in  the  Participant  in  accordance  with such
vesting schedule relating to such Restricted  Shares,  if any,  as the Committee
may establish in the relevant  Award  Agreement   (the  "Restriction   Period").
Notwithstanding  the   preceding  sentence,   in no event shall the  Restriction
Period  be less   than six (6)   months  after  the date of  grant.  During  the
Restriction  Period, such stock  shall be and  remain unvested and a Participant
may not sell, assign,  transfer,  pledge,  encumber  or otherwise  dispose of or
hypothecate  such Award.   Upon  satisfaction   of the vesting  schedule and any
other applicable restrictions,   terms and conditions,  the Participant shall be
entitled to receive payment of the Restricted Shares  or a portion thereof,   as
the case may be, as provided in Section 8.4 of the Plan.

                    8.4  Payment  of   Restricted   Share   Grants.   After  the
satisfaction   and/or  lapse  of  the    restrictions,   terms   and  conditions
established by the Committee in respect of a  grant of Restricted Shares,  a new
certificate,  without  the legend set forth  in Section 8.1  of the Plan for the
number  of  shares  of  Common   Stock  which  are  no  longer  subject  to such
restrictions,  terms and conditions shall,  as soon as practicable   thereafter,
be delivered to the Participant.

                                       32
<PAGE>

                    8.5  Shareholder  Rights.  A  Participant  shall have,  with
respect to the shares of Common Stock underlying  a grant  of Restricted Shares,
all of the rights of a  shareholder  of  such stock   (except as such rights are
limited or restricted under the Plan  or in the  relevant Award Agreement).  Any
stock dividends paid in  respect of  unvested Restricted Shares shall be treated
as additional  Restricted Shares and  shall be subject  to the same restrictions
and other terms and conditions that apply to the unvested  Restricted  Shares in
respect of which such stock dividends are issued.

         9.  PERFORMANCE UNITS

                    9.1 Terms and Conditions. Performance Units shall be subject
to the terms and  conditions  set forth in  this  Section 9  and any  additional
terms and  conditions,  not  inconsistent  with the  express  provisions  of the
Plan, as the Committee shall set forth in the relevant Award Agreement.

                    9.2 Performance  Unit Grants. A Performance Unit is an Award
of units (with each unit representing such  monetary amount  as is designated by
the Committee in the Award  Agreement)  granted to  a  Participant,   subject to
such terms and  conditions  as the  Committee   deems  appropriate,   including,
without  limitation,  the requirement that  the Participant   forfeit such units
(or a portion  thereof)  in the event   certain  performance  criteria or  other
conditions are not met within a designated period of time.

                    9.3  Grants.  Performance  Units may be granted  alone or in
addition to any other Awards  under the Plan.  Subject to the terms of the Plan,
the Committee shall determine the number of Performance Units to be granted to a
Participant  and the Committee may impose  different terms and conditions on any
particular Performance Units granted to any Participant.
                                   
                    9.4 Performance Goals and Performance Periods.  Participants
receiving a grant of Performance Units shall  only earn  into and be entitled to
payment in  respect  of such  Awards  if  the  Company  and/or  the  Participant
achieves certain  performance  goals  (the  "Performance  Goals")  during and in
respect of a designated  performance  period  (the "Performance  Period").   The
Performance   Goals and the   Performance  Period  shall be  established  by the
Committee,  in its sole discretion.  The Committee  shall establish  Performance
Goals for each Performance  Period prior to, or as soon  as practicable   after,
the  commencement  of  such  Performance   Period.  The  Committee   shall  also
establish a schedule or schedules  for   Performance  Units  setting   forth the
portion of the Award which will be earned or  forfeited  based  on the degree of
achievement,  or lack  thereof,  of the   Performance  Goals  at the  end of the
relevant  Performance   Period.  In setting Performance Goals, the Committee may
use, but shall not be limited to, such measures as  total  shareholder   return,
return on equity,  net earnings  growth,   sales or revenue growth,   cash flow,
comparisons to peer companies, individual or  aggregate Participant  performance
or such other measure or measures of  performance as the Committee,  in its sole
discretion,  may deem appropriate.   Such performance measures  shall be defined
as to their  respective  components  and meaning  by the Committee  (in its sole
discretion).  During any   Performance  Period,   the  Committee  shall have the
authority to adjust the  Performance   Goals and/or the   Performance  Period in
such manner as the Committee,  in its sole discretion,  deems appropriate at any
time and from time to time.

                                       33
<PAGE>
                    9.5 Payment of Units. With respect to each Performance Unit,
the Participant  shall, if the applicable  Performance Goals have been achieved,
or partially achieved,  as determined by the Committee,  in its sole discretion,
by the Company and/or the Participant during the relevant Performance Period, be
entitled to receive  payment in an amount equal to the designated  value of each
Performance Unit times the number of such units so earned. Payment in settlement
of earned  Performance  Unit shall be made as soon as practicable  following the
conclusion of the respective  Performance Period in cash, in unrestricted Common
Stock, or in Restricted Shares, or in any combination  thereof, as the Committee
in its sole  discretion,  shall  determine  and  provide in the  relevant  Award
Agreement.

         10. DEFERRAL ELECTIONS/TAX  REIMBURSEMENTS.  The Committee may permit a
Participant  to elect to defer  receipt of any  payment of  cash or any delivery
of shares of Common Stock that would  otherwise be  due to  such  Participant by
virtue of the  exercise,  earn  out or  settlement   of any Award made under the
Plan. If any such election  is permitted,   the Committee  shall establish rules
and procedures for such deferrals,   including,  without limitation, the payment
or crediting of reasonable  interest on such deferred  amounts credited in cash,
and the payment or crediting of dividend   equivalents   in respect of deferrals
credited  in units of Common  Stock.   The  Committee  may  also  provide in the
relevant Award  Agreement for  a  tax  reimbursement  cash payment to be made by
the  Company  in  favor   of  any   Participant  in   connection  with  the  tax
consequences resulting from the grant, exercise,  settlement or earn out of  any
Award made under the Plan.

         11. DIVIDEND EQUIVALENTS.  In addition to the provisions of Section 8.5
of the Plan, Awards of Stock Options and/or Stock Appreciation Rights,  may,  in
the sole discretion of the  Committee and if  provided for in the relevant Award
Agreement,   earn dividend   equivalents.  In respect of any such Award which is
outstanding on a  dividend  record date for Common Stock, the Participant  shall
be credited with  an amount  equal to the amount of cash or stock dividends that
would have been  paid on  the shares of Common  Stock  covered by such Award had
such covered shares been issued  and   outstanding on such dividend record date.
The  Committee  shall  establish  such   rules   and  procedures  governing  the
crediting of such dividend  equivalents,   including,   without limitation,  the
amount,  the  timing,  form  of  payment   and   payment   contingencies  and/or
restrictions  of  such  dividend  equivalents,  as  it   deems  appropriate   or
necessary.

         12.  TERMINATION OF EMPLOYMENT OR SERVICES.

                    12.1  General.  Except as is  otherwise  provided (a) in the
relevant Award Agreement as determined by the Committee (in its sole discretion)
or (b) in the Participant's then effective  employment or consulting  agreement,
if any, the following terms and conditions shall apply as appropriate and as not
inconsistent  with the terms and  conditions,  if any,  contained  in such Award
Agreement and/or such employment or consulting agreement:
                                  
                    12.1.1  Options/SARs.  Subject to any  determination  of the
Committee  pursuant to Section 6.6 of the Plan,  if a  Participant's  employment
with or performance of services for the Company and its Subsidiaries  terminates
for any reason any then  unexercisable  Stock Options and/or Stock  Appreciation
Rights  shall be  forfeited  and  canceled by the  Company.  If a  Participant's
employment with or performance of services for the Company and its  Subsidiaries
terminates for any reason,  such  Participant's  rights, if any, to exercise any
then exercisable Stock Options and/or Stock  Appreciation  Rights, if any, shall
terminate

                                       34
<PAGE>

                   (a)     one (1) year  after the date of such  termination  or
                           the last day on which  services were  performed  (but
                           not beyond the stated  term of any such Stock  Option
                           and/or Stock  Appreciation  Right as determined under
                           Sections 6.4 and 7.4 of the Plan), if the Participant
                           has been  employed  by or  provided  services  to the
                           Company  and/or any  Subsidiary  for at least one (1)
                           year but not more than three (3) years;

                   (b)     two (2) years after the date of such  termination  or
                           the last day on which  services were  performed  (but
                           not beyond the stated  term of any such Stock  Option
                           and/or Stock  Appreciation  Right as determined under
                           Sections 6.4 and 7.4 of the Plan), if the Participant
                           has been  employed  by or  provided  services  to the
                           Company  and/or any Subsidiary for at least three (3)
                           years but not more than five (5) years;

                   (c)     three (3) years after the date of such  determination
                           or the last day on which services were performed (but
                           not beyond the stated  term of any such Stock  Option
                           and/or Stock  Appreciation  Right as determined under
                           Sections 6.4 and 7.4 of the Plan), if the Participant
                           has been  employed  by or  provided  services  to the
                           Company  and/or any  Subsidiary for at least five (5)
                           years but not more than seven (7) years;

                    (d)    four (4) years after the date of such  termination or
                           the last day on which  services were  performed  (but
                           not beyond the stated  term of any such Stock  Option
                           and/or Stock  Appreciation  Right as determined under
                           Sections 6.4 and 7.4 of the Plan), if the Participant
                           has been  employed  by or  provided  services  to the
                           Company  and/or any Subsidiary for at least seven (7)
                           years but not more than nine (9) years;

                   (e)     five (5) years after the date of such  termination or
                           the last day on which  services were  performed  (but
                           not beyond the stated  term of any such Stock  Option
                           and/or Stock  Appreciation  Right as determined under
                           Sections 6.4 and 7.4 of the Plan), if the Participant
                           has been  employed  by or  provided  services  to the
                           Company  and/or any  Subsidiary for at least nine (9)
                           years;

provided,  however,   that if such   termination or service  cessation is due to
death, Disability or  Retirement,   the exercise period shall in no case be less
than two (2) years  after the  date of such   termination  or service  cessation
(but  not  beyond  the  stated  term of  any such   Stock  Option  and/or  Stock
Appreciation  Right as  determined  under   Sections  6.4  and 7.4 of the Plan).
Notwithstanding  the  above,  the  Committee,   in  its   sole  discretion,  may
determine that any such Participant's   Stock Options  and/or Stock Appreciation
Rights, if any, to the extent  exercisable  immediately prior to any termination
of employment or consulting services,  may remain exercisable for an  additional
period of time after any  period set  forth above expires  (subject to any other
applicable terms and provisions of  the Plan  and the relevant Award Agreement),
but not  beyond  the  stated  term  of any   such  Stock   Option  and/or  Stock
Appreciation Right.

                                       35
<PAGE>

                    12.2 Restricted  Shares. If a Participant's  employment with
or performance of services for the Company and its  Subsidiaries terminates  for
any reason  (other than due  to  Disability,   Retirement or death) prior to the
satisfaction and/or lapse of the  restrictions,  terms and conditions applicable
to a grant of Restricted  Shares,   such Restricted Shares shall  immediately be
canceled  and the  Participant   (and  such  Participant's  estate,   designated
beneficiary  or  other  legal   representative,   as  the  case  may  be  and as
determined by the Committee) shall forfeit any rights or  interests in and  with
respect  to  any  such  Restricted   Shares.   Notwithstanding  anything  to the
contrary  in this  Section  12, the  Committee,   in its sole  discretion,   may
determine,  prior  to or   within  ninety   (90)  days  after  the  date of such
termination, that all or a  portion  of any such Participant's Restricted Shares
shall not be so canceled  and  forfeited.   If the  Participant's  employment or
performance  of services terminates  due to death, Disability or Retirement, the
Participant  (and such Participant's  estate,   designated  beneficiary or other
legal  representative,  as the case may  be and  as determined by the Committee)
shall become 100% vested in any such Participant's  Restricted Shares as of  the
date of any such termination.

                    12.2.1 Performance Units. If a Participant's employment with
or performance of services for the Company and its  Subsidiaries terminates  for
any reason  (other than due to  Disability,  Retirement or death)  prior to  the
completion of any Performance Period, any Performance  Units granted  in respect
of such  Performance  Period shall  immediately be  canceled by  the Company and
the Participant   (and such  Participant's  estate,   designated  beneficiary or
other  legal  representative,   as the  case  may be and as  determined  by  the
Committee)  shall  forfeit any rights or  interests  in  and with respect to any
such  Performance  Units.   Notwithstanding  anything   to the  contrary in this
Section 19, the Committee,   in its sole discretion may determine,   prior to or
within ninety  (90)  days after the date of any such termination,  that all or a
portion of  any  such  Participant's  Performance Units shall not be so canceled
and forfeited upon  termination  of  employment or consulting   services for any
reason  or  for a  particular  reason.  If  the   Participant's  employment   or
performance of services terminates due to death,  Disability or Retirement,  the
Participant  (and such Participant's   estate,  designated  beneficiary or other
legal  representative,  as the  case may be  and as determined by the Committee)
shall  be  entitled  to earn  into  such   Participant's   Performance  Units in
accordance with Section 9 of the Plan; provided,   however,   that any such earn
out  (determined  in good   faith by the  Committee)   shall be  proportionately
reduced  based on the  number of days   transpired  in the relevant  Performance
Periods prior to such death,  Disability or  Retirement over the total number of
calendar days in any such relevant Performance Period.

           13.  NON-TRANSFERABILITY  OF AWARDS.  No Award  under the Plan or any
Award Agreement,  and no rights or interests herein or therein, shall or may  be
assigned,  transferred,  sold,  exchanged,  encumbered,  pledged  or   otherwise
hypothecated  or disposed of by a Participant  or any  beneficiary(ies)   of any
Participant,  except by testamentary disposition by the Participant or the  laws
of  intestate  succession.  No such  interest  shall be subject  to   execution,
attachment or similar legal process, including, without limitation,  seizure for
the  payment  of  the  Participant's  debts,  judgments,  alimony  or   separate
maintenance.  Any attempt to sell, exchange, transfer, assign, pledge,  encumber
or otherwise  dispose of or hypothecate  in any way any such awards,   rights or
interests or the levy of any  execution,  attachment  or similar  legal  process
thereon,  contrary to the terms of this Plan shall be null and void and  without
legal force or effect. During the lifetime of a Participant,  Stock Options  and
Stock Appreciation Rights are exercisable only by the Participant.

                                       36
<PAGE>

           14.    CHANGES IN CAPITALIZATION AND OTHER MATTERS

                    14.1     No Corporate Action Restriction.  The  existence of
the Plan,  any Award  Agreement and/or  the Awards  granted hereunder  shall not
limit,  affect or restrict  in any way the  right or power  of the Board  or the
shareholders   of   the  Company to  make  or   authorize  (a)  any  adjustment,
Recapitalization,   reorganization   or other  change in the  Company's   or any
Subsidiary's capital structure  or its business, (b) any  merger,  consolidation
or  change  in  the  ownership  of the  Company or any Subsidiary, (c) any issue
of  secured  or  unsecured  indebtedness, capital, preferred or prior preference
stocks ahead of or affecting the Company's or any Subsidiary's  capital stock or
the  rights  thereof,  (d) any dissolution  or liquidation of the Company or any
Subsidiary,  (e) any sale or transfer of all or any part of the Company's or any
Subsidiary's  assets or business or (f) any other  corporate  act or  proceeding
by the  Company  or  any  Subsidiary.  No Participant, beneficiary  or any other
person shall have any claim against any member of  the Board or  the  Committee,
the  Company or  any  Subsidiary  or  any employees,  officers or  agents of the
Company or any Subsidiary, as a result of any such action.

                   14.2 Recapitalization Adjustments. In the event of any change
in capitalization affecting the Common Stock, including,   without limitation, a
stock  dividend  or other  distribution,  stock  split,   reverse  stock  split,
Recapitalization,  consolidation,  subdivision,   split-up, spin-off, split-off,
combination  or  exchange  of  shares  or  other   form  of   reorganization  or
Recapitalization,  or any other  change  affecting the Common  Stock,  the Board
shall authorize and make such  proportionate  adjustments,  if any, as the Board
deems appropriate to reflect such change, including,  without limitation,   with
respect to the aggregate  number of  shares of the Common Stock for which Awards
in respect  thereof may be granted under the  Plan, the maximum number of shares
of the Common  Stock  which may be granted or awarded to  any  Participant,  the
number of shares of the Common Stock covered by each outstanding Award,  and the
exercise  price  or other  price  per  share of  Common  Stock  in   respect  of
outstanding Awards.
                                       
                   14.3       Certain  Mergers.

                   14.3.1  If the  Company  enters  into or is  involved  in any
merger, reorganization or other  business combination  with any person or entity
(such merger,  reorganization or other business   combination  to be referred to
herein  as a "Merger  Event")  and  as a result  of any  such  Merger  Event the
Company  will be or is the   surviving  corporation,   a  Participant  shall  be
entitled,  as of the date of the  execution of  the   agreement  evidencing  the
Merger Event  (the "Execution  Date")  and with respect to both  exercisable and
unexercisable  Stock Options and/or  Stock  Appreciation Rights (but only to the
extent not previously  exercised),  to receive  substitute stock  options and/or
stock  appreciation   rights   in  respect  of  the   shares  of  the  surviving
corporation on such  terms and conditions,   as to the number of shares, pricing
and  otherwise,  which  shall  substantially   preserve  the value,   rights and
benefits of any affected  Stock Options  or Stock   Appreciation  Rights granted
hereunder  as  of  the  date   of  the   consummation   of  the   Merger  Event.
Notwithstanding  anything to the contrary in this Section   14.3, if any  Merger
Event occurs, the Company shall have the right,  but not the obligation,  to pay
to each affected Participant an amount  in cash or  certified check equal to the
excess of the Fair Market  Value of the  Common Stock  underlying   any affected
unexercised  Stock  Options or Stock   Appreciation   Rights as of the Execution
Date  (whether then  exercisable  or not)  over the aggregate  exercise price of
such unexercised Stock Options  and/or Stock  Appreciation  Rights,  as the case
may be.

                                       37
<PAGE>

                    14.3.2  If,  in the  case of a Merger  Event  in  which  the
Company will not be,  or is not,  the   surviving  corporation,  and the Company
determines  not to make the   cash or  certified  check  payment   described  in
Section  14.3.1 of the Plan,  the  Company   shall  compel and  obligate,   as a
condition of the  consummation of the Merger  Event, the surviving or  resulting
corporation  and/or the other party to the Merger Event,  as necessary,   or any
parent, subsidiary or acquiring corporation thereof,  to grant,  with respect to
both  exercisable and  unexercisabie  Stock  Options and/or Stock   Appreciation
Rights (but only to the extent not   previously  exercised),   substitute  stock
options  or stock   appreciation  rights in   respect of the shares of common or
other capital stock of  such  surviving or  resulting  corporation on such terms
and conditions, as to the number of shares,  pricing and otherwise,  which shall
substantially  preserve the  value,  rights and benefits of any  affected  Stock
Options and/or Stock  Appreciation   Rights previously  granted hereunder  as of
the date of the consummation of the Merger Event.

                    14.3.3 Upon receipt by any affected  Participant of any such
cash, certified check or substitute stock options  or stock  appreciation rights
as a result  of any such  Merger  Event,   such  Participant's   affected  Stock
Options and/or Stock Appreciation  Rights  for which such cash,  certified check
or substitute awards was received shall be thereupon  canceled without  the need
for obtaining the consent of any such affected Participant.

                    14.3.4  The   foregoing   adjustments   and  the  manner  of
application of the foregoing provisions,  including,  without limitation,    the
issuance of any  substitute  stock options  and/or stock   appreciation  rights,
shall be determined in good faith by the   Committee,   in its sole  discretion.
Any such adjustment may provide for the elimination of fractional shares.

          15.   CHANGE OF CONTROL

                   15.1 Acceleration of Awards Vesting. Anything in the Plan, to
the contrary notwithstanding,  if a Change of Control of the Company occurs  (a)
all Stock  Options  and/or  Stock  Appreciation  Rights  then  unexercised   and
outstanding  shall become fully  vested and  exercisable  as of the date of  the
Change of Control, (b) all restrictions, terms and conditions applicable to  all
Restricted  Shares then outstanding  shall be deemed lapsed and satisfied as  of
the date of the  Change of  Control  and (c) the  Performance  Period  shall  be
deemed completed, all Performance Goals shall be deemed attained at the  highest
levels and all  Performance  Units shall be deemed to have been fully earned  as
of the date of the Change of Control. The immediately  preceding sentence  shall
apply to only those  Participants (i) who are employed by or perform  consulting
services for the Company and/or one of its  Subsidiaries  as of the date of  the
Change of Control or (ii) to whom Section 15.3 below is applicable.

                   15.2  Payment   After  Change  of  Control.   Notwithstanding
anything to the contrary in the Plan, within thirty (30)  days after a Change of
Control  occurs,  (a) the holder of an Award of Restricted   Shares vested under
Section  15.1(b) above shall receive a new  certificate for  such shares without
the legend set forth in Section 8 of the Plan and  (b) the holder of Performance
Units shall receive  payment of the value of such grants in cash at  the highest
levels.   

                                       38
<PAGE>

                    15.3  Termination  as a  Result  of  a  Change  of  Control.
Anything in the Plan to the contrary   notwithstanding,   if a Change of Control
occurs  and  if  the   Participant's   employment  or   consulting  services  is
terminated before such Change of  Control and it is  reasonably  demonstrated by
the  Participant  that such   termination   (a) was at the request,  directly or
indirectly,  of a third party who has taken   steps  reasonably   calculated  to
effect the Change of Control or  (b) otherwise  arose in  connection  with or in
anticipation  of the  Change of Control,   then for purposes of this Section 15,
the Change of Control  shall be deemed to have  occurred  immediately   prior to
such Participant's termination.

           16.       AMENDMENT, SUSPENSION AND TERMINATION

                    16.1 In General. The Board may suspend or terminate the Plan
(or any  portion  thereof)  at  any time and  may amend the Plan at any time and
from time to time in such  respects as the  Board may deem   advisable to insure
that  any and all  Awards  conform  to  or  otherwise  reflect   any  change  in
applicable laws or  regulations,  or to permit  the Company or the  Participants
to benefit from any change  in applicable laws  or regulations,  or in any other
respect the Board may deem to be in  the best  interests  of the  Company or any
Subsidiary;  provided,   however,   that no such  amendment  to the Plan  shall,
without majority shareholder  approval, (a)  except as provided in Section 14 of
the Plan,  materially  increase the number of  shares of Common  Stock which may
be  issued  under the Plan,   (b)  materially  modify  the   requirements  as to
eligibility  for   participation  in the Plan or  (c)  materially  increase  the
benefits  accruing to Participants  under the Plan  (this Section  16.1(c) shall
not apply to any amendment or  modification  of  any Award  Agreement  permitted
under  Section  16.2  if such  amendment  or   modification  would  not  require
shareholder  approval under SEC Rule 16b-3).  No such amendment,   suspension or
termination   shall   (x)  materially   adversely  effect   the  rights  of  any
Participant under any  outstanding Stock Options,  Stock   Appreciation  Rights,
Performance   Units or  Restricted   Share  grants,  without the consent of such
Participant  or (y) make any  change  that would  disqualify  the Plan,   or any
other plan of the Company or any  Subsidiary  intended to be so qualified,  from
(i) the exemption provided by SEC Rule 16b-3,  (ii) the benefits  provided under
Section  429 of the  Code,   or  any   successor  provisions  thereto  or  (iii)
entitlement  to  deductions   under  Code   Section  162(m),  or  any  successor
provision thereto.

                    16.2 Award  Agreement  Modifications.  The Committee may (in
its sole  discretion)  amend or  modify   at any time and from time  to time the
terms and  provisions of any  outstanding  Stock Options,   Stock   Appreciation
Rights,  Performance  Units or  Restricted  Share grants,   in any manner to the
extent that the  Committee  under the Plan  or any Award  Agreement  could  have
initially   determined   the  restrictions,  terms and  provisions of such Stock
Options, Stock Appreciation Rights,   Performance Units and/or  Restricted Share
grants, including,  without limitation,  changing or acceleratin   (a) the  date
or dates as of which such Stock  Options  or Stock  Appreciation  Rights   shall
become  exercisable,  (b) the date or  dates as of  which such Restricted  Share
grants shall become vested or  (c) the   performance  period or goals in respect
of any Performance  Units. No such amendment  or modification  shall,   however,
materially adversely affect the rights of  any Participant  under any such Award
without the consent of such Participant.

                                       39
<PAGE>
         17.   MISCELLANEOUS

                    17.1 Tax  Withholding.  The Company  shall have the right to
deduct  from any  payment or  settlement  under the Plan,   including,   without
limitation,  the exercise of any Stock  Option or  Stock Appreciation  Right, or
the delivery,  transfer or vesting of  any Common  Stock or  Restricted  Shares,
any federal,  state, local or other taxes  of any kind which  the Committee,  in
its sole  discretion,  deems  necessary to  be withheld to  comply with the Code
and/or any other applicable law,  rule or regulation.   If the Committee, in its
sole discretion, permits shares of Common Stock  to be used to  satisfy any such
tax  withholding,  such Common   Stock shall be  valued based on the Fair Market
Value of such  stock as of the date  the tax withholding is required to be made,
such date to be  determined by the  Committee. The Committee may establish rules
limiting  the  use  of  Common  Stock  to   meet  withholding   requirements  by
Participants who are subject to Section 16 of the Exchange Act.

                    17.2 No  Right  to  Perform  Future  Services.  Neither  the
adoption of the Plan,  the granting of any Award nor  the execution of any Award
Agreement  shall confer  upon any employee  or  consultant of the Company or any
Subsidiary  any right to  continued  employment  or  performance  of  consulting
services with the Company or any Subsidiary,   as the case may be,  nor shall it
interfere in any way with  the right,  if any,  of the Company or any Subsidiary
to terminate the employment of any  employee or  the consulting  services of any
consultants at any time for any reason.

                   17.3  Unfunded  Plan.  The  Plan  shall be  unfunded  and the
Company shall not be required to segregate  any  assets in  connection  with any
Awards under the Plan.  Any liability of  the Company to any person with respect
to any Award under the Plan or  any Award  Agreement  shall be based solely upon
the contractual  obligations that  may be created as a result of the Plan or any
such award or agreement.  No such  obligation of the Company shall be  deemed to
be secured by any pledge of,  encumbrance on or other  interest in, any property
or asset of the Company or any Subsidiary. Nothing  contained in the Plan or any
Award  Agreement  shall be construed as creating in  respect of any  Participant
(or  beneficiary  thereof or any other person) any equity or other   interest of
any kind in any assets of the Company or any  Subsidiary or creating a  trust of
any kind or a  fiduciary  relationship  of any kind  between the  Company,   any
Subsidiary  and/or any such Participant,  any beneficiary  thereof or  any other
person.

                   17.4  Payments to a Trust.  The  Committee is  authorized  to
cause to be  established  a trust  agreement  or several   trust  agreements  or
similar  arrangements from which the Committee may  make payments of amounts due
or to become due to any Participants under the Plan.
                                     
                   17.5  Other  Company  Benefit  and   Compensation   Programs.
Payments  and other  benefits  received  by a  Participant  under  an Award made
pursuant to the Plan shall not be deemed a part of a  Participant's compensation
for purposes  of the  determination of benefits under any other employee welfare
or  benefit  plans or  arrangements,   if any,  provided  by the  Company or any
Subsidiary  unless expressly   provided in such other plans or arrangements,  or
except where  the Board  expressly  determines  in writing that  inclusion of an
Award  or  portion  of an  Award  should   be  included  to  accurately  reflect
competitive  compensation practices or to recognize  that an Award has been made
in  lieu  of a  portion  of  competitive  annual  base  salary   or  other  cash
compensation.  Awards under the Plan may be made  in addition to, in combination
with, or as alternatives  to, grants,  awards or  payments under any other plans
or arrangements of the Company or its  Subsidiaries.  The  existence of the Plan
notwithstanding,   the  Company  or  any   Subsidiary   may  adopt   such  other
compensation plans  or programs and additional  compensation  arrangements as it
deems necessary to attract, retain and motivate employees or consultants.

                                       40
<PAGE>

                   17.6 Listing,  Registration  and Other Legal  Compliance.  No
Awards or shares of the Common  Stock shall be  required to be issued or granted
under the Plan unless legal  counsel  for the Company  shall be  satisfied  that
such issuance or grant will be in compliance   with all  applicable  federal and
state  securities  laws  and  regulations  and  any  other  applicable   laws or
regulations.  The Committee may require, as a condition of  any payment or share
issuance, that certain agreements, undertakings,  representations,  certificates
and/or  information,  as the Committee may deem necessary or  advisable,  in its
sole  discretion,  be executed or  provided to the Company to assure  compliance
with all such applicable laws or   regulations.  Certificates  for shares of the
Restricted  Shares and/or Common Stock   delivered under the Plan may be subject
to such stock-transfer  orders and such other  restrictions as the Committee may
deem advisable under the rules,  regulations or other  requirements  of the SEC,
any stock  exchange  upon or trading  system in which the Common   Stock is then
listed or  traded  and any  applicable  federal  or state  securities  law.   In
addition,  if,  at any time  specified  herein  (or in any Award   Agreement  or
otherwise) for (a) the making of any Award, or the making of any  determination,
(b) the issuance or other distribution of Restricted Shares and/or  Common Stock
or (c) the payment of amounts to or through a  Participant  with  respect to any
Award,  any law,  rule,  regulation or other   requirement  of any  governmental
authority or agency shall  require  either the Company,   any  Subsidiary or any
Participant   (or  any   estate,   designated   beneficiary   or   other   legal
representative  thereof, as the case may be and as determined by  the Committee)
to take any action in connection with any such  determination,   any such shares
to be  issued  or  distributed,  any such  payment  or the  making   of any such
determination, as the case may be, shall be deferred until such  required action
is taken.  With  respect to persons  subject to Section 16 of the   Exchange Act
transactions  under  the Plan  are  intended  to  comply  with  all   applicable
conditions  of SEC Rule 16b-3.  To the extent any  provision of the Plan or  any
action by the  administrators of the Plan fails to so comply with such rule,  it
shall be deemed  null and  void,  to the  extent  permitted  by law and   deemed
advisable by the Committee.

                   17.7 Award  Agreements.  Each Participant  receiving an Award
under the Plan shall enter into an Award  Agreement  with  the Company in a form
specified  by  the  Committee.   Each  such  Participant  shall  agree   to  the
restrictions,  terms and  conditions  of the Award set forth therein and  in the
Plan.

                   17.8 Designation of Beneficiary.  Each Participant to whom an
Award has been made under the Plan may designate a beneficiary  or beneficiaries
to exercise  any option or to receive any payment  which  under the terms of the
Plan and the relevant Award  Agreement may  become  exercisable or payable on or
after the  Participant's  death.  At any time,  and from time to time,  any such
designation may be changed or canceled by the  Participant  without the  consent
of any such beneficiary.  Any such designation,   change or cancellation must be
on a form provided for that purpose by the Committee and shall not be  effective
until received by the Committee.  If no   beneficiary  has been  designated by a
deceased Participant,  or if the designated  beneficiaries have  predeceased the
Participant,   the  beneficiary  shall  be  the  Participant's  estate.  If  the
Participant  designates more than one beneficiary,   any payments under the Plan
to such beneficiaries  shall be made in equal shares unless the  Participant has
expressly designated otherwise,  in which case the payments shall be made in the
shares designated by the Participant.

                                       41
<PAGE>
                   17.9 Leaves of  Absence/Transfers.  The Committee  shall have
the power to promulgate rules and regulations and  to make determinations, as it
deems  appropriate,  under the Plan in respect  of any leave of absence from the
Company  or any  Subsidiary  granted to a  Participant.   Without  limiting  the
generality of the foregoing, the Committee may determine  whether any such leave
of absence shall be treated as if the   Participant  has been  terminated by the
Company or any such Subsidiary.  If a  Participant transfers within the Company,
or to or from any Subsidiary, such Participant shall  not be deemed to have been
terminated as a result of such transfers.

                   17.10 Loans.  Subject to  applicable  law, the  Committee may
provide,  pursuant to Plan rules,  for the   Company or any  Subsidiary  to make
loans to  Participants  to finance the exercise  price of any Stock Options,  as
well as the  withholding  obligation  under  Section 17.1 of the Plan and/or the
estimated  or  accrual  taxes  payable  by the  Participant  as a  result of the
exercise of such Stock Option and the  Committee  may  prescribe  the  terms and
conditions of any such loan.

                   17.11   Governing   Law.  The  Plan  and  all  actions  taken
thereunder  shall be governed by and  construed in  accordance  with the laws of
the State of Delaware,  without  reference to the principles of conflict of laws
thereof.  Any titles and headings  herein are for  reference  purposes only, and
shall in no way limit, define or otherwise affect  the meaning,  construction or
interpretation of any provisions of the Plan.

                   17.12  Effective  Date.  The Plan shall be effective upon its
adoption by the Board,  subject to the   approval  of the Plan by the  Company's
shareholders in accordance with SEC Rule 16b-3 and Section 422 of the Code.




                                       42
<PAGE>


                              NEUROGEN CORPORATION

                          35 Northeast Industrial Road
                          Branford, Connecticut 06405

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                    FOR THE SPECIAL MEETING OF STOCKHOLDERS

     Harry H. Penner,  Jr.,  John F. Tallman  and  Stephen R. Davis,  or each of
them,  with all powers of  substitution  and  revocation,  are hereby  appointed
attorneys and proxies and are authorized to represent the undersigned,  with all
powers  which the  undersigned would possess if personally present,  and to vote
the Common  Stock of Neurogen  Corporation (the "Company") held of record by the
undersigned on September 15, 1998,  at the 1998  Special Meeting of Stockholders
of Neurogen Corporation,  which is being held at the New York Palace Hotel,  455
Madison Avenue, New York, New York, on Thursday, November 5, 1998, at 3:00 p.m.,
local time,  and at any  postponements or  adjournments of that meeting,  as set
forth on the reverse, and, in their discretion, upon any other business that may
properly come before the meeting or any adjournment thereof.

                        (TO BE SIGNED ON REVERSE SIDE.)


For       Against        Abstain

- ----       ----           ----

1.  To adopt an  amendment to the  Neurogen Corporation  1993  Omnibus Incentive
Plan (the "Plan")  increasing the number  of shares to be granted in the Plan by
1,500,000 shares to a total of 4,500,000  shares in the plan.  This amendment is
being proposed in lieu of an earlier proposal (the "Withdrawn Proposal") made in
connection with Neurogen's May 1998,  Annual Meeting of Stockholders,  which was
withdrawn by the Board at the  recommendation of management prior to such Annual
Meeting. The Withdrawn Proposal would have increased the shares available in the
Plan by a larger number  than  this Proposal No. 1. Neurogen management believes
that the  smaller addition to the Plan  represented by this  Proposal No. 1 will
provide  for  more  regular  shareholder  oversight  and assessment  of  Company
performance.

This proxy  will be  voted as specified or,  if no choice is specified,  will be
voted for the proposal specified.

Please mark,  sign,  date  and return  this proxy  promptly using  the  enclosed
envelope.

Signature(s)________________________________________Dated:_______________, 1998
Note:   IF the shares  are issued in  the manes of  two or more persons, each of
them should  sign the proxy.   If the  proxy is  executed  by a corporation,  it
should be signed in the  corporate name by an  authorized officer.  When signing
as attorney,  executor,  administrator,  trustee  or  guardian  or in  any other
representative capacity, give your full title as such.


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