NEUROGEN CORP
SC 13G/A, 1999-03-15
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549




                                  SCHEDULE 13G
                    Under the Securities Exchange Act of 1934
                               (Amendment No. 2)*




                              Neurogen Corporation
- -------------------------------------------------------------------------------
                                (Name of Issuer)


                         Common Stock, $0.025 par value
- -------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    64124E106
- -------------------------------------------------------------------------------
                                 (CUSIP Number)
- -------------------------------------------------------------------------------

                                  March 5, 1999
- -------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

|_|  Rule 13d-1(b)
|X|  Rule 13d-1(c)
|_|  Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


<PAGE>


                                       13G
- --------------------                                        -------------------
CUSIP No.  64124E106                                        Page 2 of 22 Pages
- --------------------                                        -------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             Four Partners
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             New York
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             -0-
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          -0-
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      -0-
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      0%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      PN
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                        -------------------
CUSIP No.  64124E106                                        Page 3 of 22 Pages
- --------------------                                        -------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             Four-Fourteen Partners LLC
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             Delaware
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             300,000
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          300,000
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      300,000
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      2.1%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      OO
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                        -------------------
CUSIP No.  64124E106                                        Page 4 of 22 Pages
- --------------------                                        -------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             Andrew H. Tisch
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             409,625
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          409,625
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      409,625
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      2.8%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      IN
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                        -------------------
CUSIP No.  64124E106                                        Page 5 of 22 Pages
- --------------------                                        -------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             Daniel R. Tisch
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             409,625
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          409,625
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      409,625
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      2.8%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      IN
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                        -------------------
CUSIP No.  64124E106                                        Page 6 of 22 Pages
- --------------------                                        -------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             James S. Tisch
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             409,625
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          409,625
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      409,625
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      2.8%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      IN
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                        -------------------
CUSIP No.  64124E106                                        Page 7 of 22 Pages
- --------------------                                        -------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             Thomas J. Tisch
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- ------------ ------------------------------------------------------------------
                                      5      SOLE VOTING POWER

                                             409,625
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          409,625
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      409,625
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      2.8%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      IN
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                        -------------------
CUSIP No.  64124E106                                        Page 8 of 22 Pages
- --------------------                                        -------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             The Andrew H. Tisch 1999 Annuity Trust II
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|
- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             409,625
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          409,625
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      409,625
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      2.8%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      OO
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                        -------------------
CUSIP No.  64124E106                                        Page 9 of 22 Pages
- --------------------                                        -------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             The Daniel R. Tisch 1999 Annuity Trust II
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             409,625
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          409,625
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      409,625
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      2.8%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      OO
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                        -------------------
CUSIP No.  64124E106                                        Page 10 of 22 Pages
- --------------------                                        -------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             The James S. Tisch 1999 Annuity Trust II
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             409,625
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          409,625
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      409,625
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      2.8%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      OO
- ------------ ------------------------------------------------------------------


<PAGE>


                                       13G
- --------------------                                        -------------------
CUSIP No.  64124E106                                        Page 11 of 22 Pages
- --------------------                                        -------------------


- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             The Thomas J. Tisch 1999 Annuity Trust II
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a)   |_|
                                                                     (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             United States
- --------------------------------- ---------- ----------------------------------
                                      5      SOLE VOTING POWER

                                             409,625
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-
                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          409,625
                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- --------------------------------- ---------- ----------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      409,625
- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
             CERTAIN SHARES*
                                                                           |X|
- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      2.8%
- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      OO
- ------------ ------------------------------------------------------------------


<PAGE>


Item 1.

         (a) Name of Issuer

             Neurogen Corporation (the "Issuer")

         (b) Address of Issuer's Principal Executive Offices

             35 Northeast Industrial Road
             Branford, Connecticut 06405

Item 2.

         (a) Name of Persons Filing

             This Schedule 13G is being filed jointly by the following entities
             and individuals:

             1. Four Partners, a New York general partnership ("FP");

             2. Four-Fourteen Partners, LLC, a Delaware limited liability
                company ("4-14P");

             3. Andrew H. Tisch;

             4. Daniel R. Tisch;

             5. James S. Tisch;

             6. Thomas J. Tisch (Andrew H. Tisch, Daniel R. Tisch,
                James S. Tisch and Thomas J. Tisch are referred to
                collectively as the "Messrs. Tisch");

             7. The Andrew H. Tisch 1999 Annuity Trust II ("Andrew Tisch
                GRAT II");

             8. The Daniel R. Tisch 1999 Annuity Trust II ("Daniel Tisch
                GRAT II");

             9. The James S. Tisch 1999 Annuity Trust II ("James Tisch
                GRAT II"); and

             10. The Thomas J. Tisch 1999 Annuity Trust II ("Thomas Tisch
                 GRAT II"; and collectively with Andrew Tisch GRAT II,
                 Daniel Tisch GRAT II and James Tisch GRAT II, the "GRATs").

             The sole partners of FP are Andrew H. Tisch 1991 Trust, for which
             Andrew H. Tisch is the managing trustee, Daniel R. Tisch 1991
             Trust, for which Daniel R. Tisch is the managing trustee, James S.
             Tisch 1991 Trust, for which James S. Tisch is the managing trustee,
             and Thomas J. Tisch 1991 Trust, for which Thomas J. Tisch is the
             managing trustee. Thomas J. Tisch has been appointed the Manager of
             FP.

             The members of 4-14P are trusts for the benefit of the offspring of
             the Messrs. Tisch, partnerships the partners of which are such
             trusts and partnerships the partners of which are such
             partnerships. The Messrs. Tisch serve as the trustees of such




                                       12

<PAGE>


             trusts. Thomas J. Tisch has been appointed the Manager of 4-14P.

             Each of the GRATs is a grantor retained annuity trust in which the
             grantor holds an annuity interest and in which the remainder
             interest was created in favor of a trust or trusts for the
             grantor's offspring. Thomas J. Tisch is the grantor and Andrew H.
             Tisch is the trustee of Thomas Tisch GRAT II. Daniel R. Tisch is
             the grantor and James S. Tisch is the trustee of Daniel Tisch GRAT
             II. James S. Tisch is the grantor and Thomas J. Tisch is the
             trustee of James Tisch GRAT II. Andrew H. Tisch is the grantor and
             Daniel R. Tisch is the trustee of Andrew Tisch GRAT II.

             On February 26, 1999, FP purchased 190,000 Shares of Common Stock
             (as defined below), bringing its total ownership to 1,638,500
             shares of Common Stock. On March 5, 1999, the following transfers
             occurred (the "GRAT Transfers"):

             1.   FP distributed all of the shares of Common Stock it owned in
                  equal shares of 409,625 each to the four trusts that are
                  partners of FP;

             2.   Each of the four trusts that are partners of FP distributed
                  all of the 409,625 shares of Common Stock that it had received
                  from FP to the Mr. Tisch who is the beneficiary of such trust;

             3.   Each of the Messrs. Tisch contributed all of the 409,625
                  shares of Common Stock that he had received to the GRAT for
                  which he is the grantor.

             None of the GRAT Transfers was a "sale" for purposes of the
             Securities Act of 1933, as amended (the "Securities Act"), or the
             Securities Exchange Act of 1934, as amended (the "Exchange Act"),
             and collectively represented only a change in the form of
             beneficial ownership of the shares of Common Stock and not an
             actual change in the beneficial ownership of such shares of Common
             Stock.

         (b) Address of Principal Business Office or, if none, Residence

             The mailing address of FP and 4-14P is:




                                       13

<PAGE>


             c/o Thomas J. Tisch
             667 Madison Avenue
             New York, NY  10021

             The mailing address for each of the GRATs is:

             c/o Mr. Barry Bloom
             655 Madison Avenue - 8th Floor
             New York, NY  10021

             The addresses of the Messrs. Tisch are:

             Name                               Business Address
             ----                               ----------------

             Andrew H. Tisch                    667 Madison Avenue
                                                New York, NY 10021

             Daniel R. Tisch                    c/o Mentor Partners, L.P.
                                                499 Park Avenue
                                                New York, NY 10022

             James S. Tisch                     667 Madison Avenue
                                                New York, NY 10021

             Thomas J. Tisch                    667 Madison Avenue
                                                New York, NY 10021

        (c)   Citizenship

              FP is a New York general partnership and 4-14P is a Delaware
              limited liability company.

              The Messrs. Tisch are brothers and are United States citizens.

        (d)   Title of Class of Securities

              Common  Stock, $0.025 par value (the "Common Stock")

        (e)   CUSIP Number

              64124E106

Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b)
        or (c), check whether the person filing is a:

        (a)   |_| Broker or Dealer registered under Section 15 of the Act,

        (b)   |_| Bank as defined in section 3(a)(6) of the Act,

        (c)   |_| Insurance company as defined in section 3(a)(19) of the Act,

        (d)   |_| Investment company registered under section 8 of the
        Investment Company Act of 1940,

        (e)   |_| Investment Adviser registered under section 203 of the
        Investment Advisers Act of 1940,




                                       14

<PAGE>

         (f) |_| An employee benefit plan, Pension Fund which is subject to
         the provisions of the Employee Retirement Income Security Act of
         1974 or Endowment Fund; see ss.240.13d-1(b)(1)(ii)(F),

         (g)   |_| A parent holding company, in accordance with
         ss.240.13d-1(b)(ii)(G) (Note:  See Item 7),

         (h)   |_| A savings association as defined in Section 3(b) of the
         Federal Deposit Insurance Act (12 U.S.C. 1813);

         (i)   |_| A church plan that is excluded from the definition of an
         investment company under section 3(c)(14) of the Investment Company
         Act of 1940 (15 U.S.C. 80a-3);

         (j)   |_| Group, in accordance with ss.240.13d-1(b)(1)(ii)(J).

         If this statement is filed pursuant to ss. 240.13d-1(c),
         check this box      |X|.

Item 4.  Ownership

         (a-b) Amount Beneficially Owned and Percent of Class

Each GRAT owns 409,625 shares of Common Stock. 4-14P owns 300,000 shares of
Common Stock.

Set forth in the table below is the aggregate number of shares of Common Stock
beneficially owned as of the date hereof by each person or entity listed in Item
2 above, together with the percentage of outstanding shares of Common Stock
which is beneficially owned by each such person or entity.




                                       15

<PAGE>


Name of                     Amount and Nature of                   % of Class
Beneficial Owner            Beneficial Ownership                Outstanding (1)
- ---------------             --------------------                ---------------

Four Partners                          0                               0
Four-Fourteen Partners           300,000                               2.1%
Andrew H. Tisch 1991 Trust             0                               0
Daniel R. Tisch 1991 Trust             0                               0
James S. Tisch 1991 Trust              0                               0
Thomas J. Tisch 1991 Trust             0                               0
Andrew Tisch GRAT II             409,625                               2.8
Daniel Tisch GRAT II             409,625                               2.8
James Tisch GRAT II              409,625                               2.8
Thomas Tisch GRAT II             409,625                               2.8
Andrew H. Tisch                  409,625 (2)                           2.8
Daniel R. Tisch                  409,625 (2)                           2.8
James S. Tisch                   409,625 (2)                           2.8
Thomas J. Tisch                  409,625 (2)                           2.8
                                 -------                               ---
Total                          1,938,500                              13.4%  (1)



- ---------------------------
(1)    The ownership percentages set forth in the table above are based on
       14,470,319 shares of Common Stock outstanding as of November 13, 1998,
       which information was reported on the Issuer's Form 10-Q for the quarter
       ended September 30, 1998.

(2)    Does not include shares owned by 4-14P. Each of the Messrs. Tisch is
       herein reporting beneficial ownership of the shares of Common Stock owned
       by the GRAT for which he is trustee.




                                       16

<PAGE>


              (c) Set forth in the table below is information with respect to
       the number of shares of Common Stock beneficially owned as of the date
       hereof by each person or entity named in Item 2 above, indicating, with
       respect to such shares of Common Stock, whether each such person has the
       sole power to vote or direct the vote or shared power to vote or direct
       the vote and sole power to dispose or direct the disposition or shared
       power to dispose or direct the disposition.

Name of                        Power to Vote or            Power to Dispose or
Reporting Person               Direct the Vote           Direct the Disposition
- ----------------               ----------------          ----------------------
                             Sole         Shared         Sole           Shared
                             ----         ------         ----           ------
Four Partners                  0             0             0               0
Four-Fourteen Partners      300,000          0          300,000            0
Andrew H. Tisch 1991 Trust     0             0             0               0
Daniel R. Tisch 1991 Trust     0             0             0               0
James S. Tisch 1991 Trust      0             0             0               0
Thomas J. Tisch 1991 Trust     0             0             0               0
Andrew Tisch GRAT II        409,625          0          409,625            0
Daniel Tisch GRAT II        409,625          0          409,625            0
James Tisch GRAT II         409,625          0          409,625            0
Thomas Tisch GRAT II        409,625          0          409,625            0
Andrew H. Tisch (1)(2)      409,625          0          409,625            0
Daniel R. Tisch (1)(2)      409,625          0          409,625            0
James S. Tisch (1)(2)       409,625          0          409,625            0
Thomas J. Tisch (1)(2)      409,625          0          409,625            0
- --------------------

(1)    By virtue of their status as trustees of the respective GRATs, the
       Messrs. Tisch may be deemed to have power to vote or direct the vote of
       the securities owned by those GRATs and power to dispose or direct the
       disposition of the securities owned by those GRATs.

(2)    Does not include shares of Common Stock owned by 4-14P. By virtue of
       their status as trustees of the trusts which are members of 4-14P,
       partners of the partnerships that are members of 4-14P and partners of
       the partnerships that are partners of the partnerships that are members
       of 4-14P, the Messrs. Tisch may be deemed to have indirectly shared power
       to vote or direct the vote of the securities owned by 4-14P and
       indirectly shared power to dispose or direct the disposition of the
       securities owned by 4-14P. By virtue of his status as manager of 4-14P,
       Thomas J. Tisch may be deemed to have power to vote or direct the vote of
       the securities owned by 4-14P and power to dispose or direct the
       disposition of the securities owned by 4-14P.




                                       17

Item 5.    Ownership of Five Percent or Less of a Class

           As a result of the GRAT Transfers, FP is no longer the beneficial
           owner of any shares of Common Stock. Beneficial ownership of the
           shares of Common Stock previously held by FP is herein reported by
           the Messrs. Tisch and the GRATs.

Item 6.    Ownership of More than Five Percent on Behalf of Another Person

           Not applicable.

Item 7.    Identification and Classification of the Subsidiary Which Acquired
           the Security Being Reported on By the Parent Holding Company

           Not applicable.

Item 8.    Identification and Classification of Members of the Group

           Not applicable.

Item 9.    Notice of Dissolution of Group

           Not applicable.

Item 10.   Certification

                By signing below I certify that, to the best of my knowledge
           and belief, the securities referred to above were not acquired and
           are not held for the purpose of or with the effect of changing or
           influencing the control of the issuer of such securities and were
           not acquired and are not held in connection with or as a
           participant in any transaction having that purpose or effect.




                                       18

<PAGE>


                                    SIGNATURE

                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

March 15, 1999                      FOUR PARTNERS

                                    By    /s/ Thomas J. Tisch
                                      ---------------------------------------
                                      Thomas J. Tisch, Manager

                                    FOUR-FOURTEEN PARTNERS, LLC

                                    By   /s/ Thomas J. Tisch
                                      ---------------------------------------
                                      Thomas J. Tisch, Manager


                                       /s/ Andrew H. Tisch
                                    -----------------------------------------
                                           Andrew H. Tisch


                                       /s/ Daniel R. Tisch
                                    -----------------------------------------
                                           Daniel R. Tisch


                                       /s/ James S. Tisch
                                    -----------------------------------------
                                           James S. Tisch


                                       /s/ Thomas J. Tisch
                                    -----------------------------------------
                                           Thomas J. Tisch

                                    THE ANDREW H. TISCH 1999 ANNUITY TRUST I

                                    By   /s/ Daniel R. Tisch
                                      ---------------------------------------
                                      Daniel R. Tisch, Trustee




                                       19

<PAGE>

                                    THE DANIEL R. TISCH 1999 ANNUITY TRUST I

                                    By   /s/ James S. Tisch
                                      ---------------------------------------
                                      James S. Tisch, Trustee
 
                                    THE JAMES S. TISCH 1999 ANNUITY TRUST I

                                    By   /s/ Thomas J. Tisch
                                      ---------------------------------------
                                      Thomas J. Tisch, Trustee

                                    THE THOMAS J. TISCH 1999 ANNUITY TRUST I

                                    By    /s/ Andrew H. Tisch
                                      ---------------------------------------
                                      Andrew H. Tisch, Trustee




                                       20

<PAGE>


                                    AGREEMENT


              In accordance with Rule 13d-1(k)(1) under the Securities Exchange
Act of 1934, as amended, the undersigned hereby agree that this Schedule 13G
dated March 15, 1999 relating to the Common Stock, $0.025 par value per share,
of Neurogen Corporation, as the same may be amended from time to time hereafter,
is being filed with the Securities and Exchange Commission on behalf of each of
them.

Dated:  March 15, 1999



                                    FOUR PARTNERS

                                    By    /s/ Thomas J. Tisch
                                      ---------------------------------------
                                      Thomas J. Tisch, Manager
          
                                    FOUR-FOURTEEN PARTNERS, LLC

                                    By    /s/ Thomas J. Tisch
                                      ---------------------------------------
                                      Thomas J. Tisch, Manager


                                         /s/ Andrew H. Tisch
                                    -----------------------------------------
                                             Andrew H. Tisch


                                         /s/ Daniel R. Tisch
                                    -----------------------------------------
                                             Daniel R. Tisch


                                         /s/ James S. Tisch
                                    -----------------------------------------
                                             James S. Tisch


                                         /s/ Thomas J. Tisch
                                    -----------------------------------------
                                             Thomas J. Tisch




                                       21
<PAGE>


                                    THE ANDREW H. TISCH 1999 ANNUITY TRUST I

                                    By    /s/ Daniel R. Tisch
                                      ---------------------------------------
                                      Daniel R. Tisch, Trustee
         
                                    THE DANIEL R. TISCH 1999 ANNUITY TRUST I

                                    By    /s/ James S. Tisch
                                      ---------------------------------------
                                      James S. Tisch, Trustee
         
                                    THE JAMES S. TISCH 1999 ANNUITY TRUST I

                                    By    /s/ Thomas J. Tisch
                                      ---------------------------------------
                                      Thomas J. Tisch, Trustee
           
                                    THE THOMAS J. TISCH 1999 ANNUITY TRUST I

                                    By    /s/ Andrew H. Tisch
                                      ---------------------------------------
                                      Andrew H. Tisch, Trustee




                                       22


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