NEUROGEN CORP
DEF 14A, 1999-04-30
PHARMACEUTICAL PREPARATIONS
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SCHEDULE 14A
                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION

           Proxy Statement Pursuant to Section 14(a) of the Securities
                              Exchange Act of 1934

Filed by the Registrant  [x]
Filed by a party other than the Registrant [ ] 
Check the appropriate box:

[   ]   Preliminary proxy statement       [   ]   Confidential, for Use of the
[ x ]   Definitive proxy statement                Commission Only (as permitted
[   ]   Definitive additional materials           by Rule 14a-6(e) (2) )
[   ]   Soliciting material pursuant to
        Rule 14a-11(c) or Rule 14a-12

                              NEUROGEN CORPORATION
 -------------------------------------------------------------------------------
                (Name of Registrant as Specified in its Charter)

 -------------------------------------------------------------------------------
      (Name of Person(s) Filing Proxy Statement, if other than registrant)

Payment of filing fee. (Check the appropriate box):

[x] No fee required.
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

(1)      Title of each class of securities to which transaction applies:  N/A
- --------------------------------------------------------------------------------
(2)      Aggregate number of securities to which transactions applies:  N/A
- --------------------------------------------------------------------------------
(3)      Per unit price or other underlying value of transaction computed 
         pursuant to Exchange Act Rule 0-11:  N/A
- --------------------------------------------------------------------------------
(4)      Proposed maximum aggregate value of transaction:  N/A
- --------------------------------------------------------------------------------
(5)      Total fee paid:  N/A

[ ]      Fee paid previously with preliminary materials.

[ ]      Check box if any part of the fee is offset as provided by Exchange  Act
         Rule 0-11(a)(2)  and  identify  the  filing  for  which the  offsetting
         fee was paid previously.  Identify the previous filing by registration
         statement  number, or the form or schedule and the date of its filing.

(1)      Amount previously paid:
- --------------------------------------------------------------------------------
(2)      Form, schedule or Registration Statement No.:
- --------------------------------------------------------------------------------
(3)      Filing party:
- --------------------------------------------------------------------------------
(4)      Date filed:
- --------------------------------------------------------------------------------
<PAGE>

                              NEUROGEN CORPORATION




April 26, 1999



To the Stockholders of Neurogen Corporation:

     On behalf of the Board of Directors,  I cordially  invite you to attend the
1999 Annual Meeting of Stockholders of Neurogen Corporation.  The Annual Meeting
will be held on Wednesday,  May 26, 1999,  at 9:00 a.m.,  local time, at the New
York Palace Hotel at 455 Madison Avenue, New York, New York 10022.

     A  description  of business to be  conducted  at the Annual  Meeting is set
forth in the  attached  Notice  of Annual  Meeting  and  Proxy  Statement.  Also
enclosed is a copy of our 1998 Annual Report to Stockholders.

     It is important that your views be represented  whether or not you are able
to be present at the Annual  Meeting.  Please  mark,  sign,  date and return the
enclosed  proxy card  promptly in the  accompanying  postage-paid  envelope.  By
returning  the proxy,  you can help the Company  avoid the expense of  duplicate
proxy  solicitations  and possibly  having to reschedule the Annual Meeting if a
quorum of  outstanding  shares is not present or  represented  by proxy.  If you
attend the Annual  Meeting  and wish to change  your proxy  vote,  you may do so
simply by voting in person at the Annual Meeting.


                             
<PAGE>


                              NEUROGEN CORPORATION

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                           To Be Held on May 26, 1999


     NOTICE IS HEREBY GIVEN that the Annual Meeting of  Stockholders of Neurogen
Corporation  will be held on Wednesday,  May 26, 1999, at 9:00 a.m., local time,
at the New York Palace Hotel at 455 Madison  Avenue,  New York,  New York 10022,
for the following purposes:

     1. To elect eleven directors to the Board of Directors, each to hold office
until the next  Annual  Meeting of  Stockholders  of the  Company and until such
director's respective successor shall have been duly elected and qualified.

     2.  To   ratify   the   appointment   by  the   Board   of   Directors   of
PricewaterhouseCoopers  LLP as the independent  auditors for the Company for the
fiscal year ending December 31, 1999.

     3. To transact such other  business as may properly come before the meeting
or any adjournment or adjournments thereof.

     This Notice is accompanied  by a form of proxy,  a Proxy  Statement and the
Company's 1998 Annual Report to  Stockholders.  The foregoing  items of business
are more fully described in the Proxy Statement.

      In accordance with the Company's  By-laws,  the close of business on April
15,  1999  has been  fixed  as the  Record  Date  for the  determination  of the
stockholders  entitled  to notice of and to vote at the Annual  Meeting  and any
adjournment thereof.

                               





Branford, Connecticut
April 26, 1999

                                    IMPORTANT

      To ensure your representation at the meeting, you are urged to mark, sign,
date and return the enclosed  proxy as promptly as possible in the  postage-paid
envelope enclosed for that purpose.  If you attend the meeting,  you may vote in
person even if you returned a proxy.



<PAGE>

                              NEUROGEN CORPORATION
                                PROXY STATEMENT


 General
     The  enclosed  proxy is  solicited  on behalf of the Board of  Directors of
Neurogen Corporation (the "Company" or "Neurogen") for use at the Annual Meeting
of Stockholders to be held on May 26, 1999, at 9:00 a.m.,  local time, or at any
adjournment  thereof (the "Annual Meeting").  The Annual Meeting will be held at
the New York Palace Hotel at 455 Madison Avenue,  New York, New York 10022.  The
purposes of the Annual  Meeting are set forth in the  attached  Notice of Annual
Meeting of Stockholders.

     This Proxy  Statement,  the Notice of Annual Meeting of  Stockholders,  the
form of proxy and Neurogen's  Annual Report to Stockholders  are being mailed to
stockholders on or about April 28, 1999.

Record Date and Share Ownership
     Stockholders  of record on the Company's  books at the close of business on
April 15, 1999 (the "Record  Date") are entitled to vote at the Annual  Meeting.
At the Record Date,  14,706,840  shares of the Company's Common Stock, par value
$.025  per  share  (the  "Common  Stock"),  were  issued  and  outstanding.  For
information  concerning stock ownership by certain stockholders,  see "Principal
Stockholders".

Revocability of Proxies
     Any proxy given pursuant to this  solicitation may be revoked by the person
giving it at any time  before  its use by  delivering  to the  Company a written
notice of revocation  prior to the voting of the proxy or a duly executed  proxy
bearing a later date or by attending the Annual Meeting and voting in person.

Voting and Solicitation
     Each stockholder is entitled to one vote for each share of the Common Stock
held of record in his or her name on the Record Date on each matter submitted to
a vote at the Annual Meeting. Cumulative voting is not permitted with respect to
any proposal to be acted upon at the Annual Meeting.

     If properly executed and received by the Company before the Annual Meeting,
any proxy representing shares of Common Stock entitled to be voted at the Annual
Meeting and specifying how it is to be voted will be voted accordingly. Any such
proxy,  however,  which fails to specify how it is to be voted on a proposal for
which a  specification  may be made will be voted on such proposal in accordance
with the  recommendation  of the Board of Directors.  Abstentions are counted in
tabulations of the votes cast on proposals presented to stockholders, but broker
non-votes  are not counted for  purposes of  determining  whether a proposal has
been approved.

     The  presence,  in person or by proxy,  of the holders of a majority of the
outstanding  shares of Common  Stock  entitled  to vote at the  Annual  Meeting,
excluding any shares owned by the Company,  is necessary to constitute a quorum.
Abstentions  and broker  non-votes are counted for purposes of  determining  the
presence or absence of a quorum for the transaction of business.

     The cost of soliciting  proxies will be borne by the Company.  In addition,
the Company expects to reimburse brokerage firms and other persons  representing
beneficial owners of Common Stock for their expenses in forwarding  solicitation
material to such beneficial  owners.  Proxies may be solicited by certain of the
Company's  directors,   officers  and  regular  employees,   without  additional
compensation, in person or by mail, telephone, facsimile or telegram.

     Pursuant to Delaware law, the Board of Directors has appointed an inspector
to act at the Annual  Meeting.  The inspector shall carry out the duties imposed
pursuant to Section 231 of the Delaware General  Corporation Law,  including the
counting of votes.



<PAGE>
                                 PROPOSAL NO. 1:
                              ELECTION OF DIRECTORS

    Eleven  directors  are to be elected to the Board of Directors at the Annual
Meeting.  Unless otherwise  instructed,  the proxy holders will vote the proxies
received by them for the eleven  nominees of the Board of Directors named below,
all of whom are presently  directors of the Company and have served continuously
since the month and year  indicated  opposite each such  director's  name in the
following  table,  each to hold  office for a term  expiring  at the next Annual
Meeting of Stockholders of the Company and until such director's successor shall
have been duly  elected  and  qualified.  In the event  that any  nominee of the
Company is unable or  declines  to serve as a director at the time of the Annual
Meeting,  the proxies will be voted for any nominee who shall be  designated  by
the present Board of Directors to fill the vacancy.  It is not expected that any
nominee will be unable or will decline to serve as a director. In the event that
additional  persons are nominated  for election as directors,  the proxy holders
intend to vote all proxies  received by them in such a manner as will assure the
election of as many of the nominees listed below as possible,  with any required
selection among such nominees to be determined by the proxy holders.  The eleven
persons  receiving  the highest vote totals shall be elected as directors of the
Company.

     The Company's Board of Directors  recommends a vote FOR the nominees listed
below:
<TABLE>
<CAPTION>
<S>                              <C>        <C>                                               <C>    
Name of Nominees                 Age     Principal Occupation                                 Director Since
- -----------------               ----     --------------------                                 --------------    
Barry M. Bloom, Ph.D.            70      Former Executive Vice President, Pfizer Inc          December 1993

Robert N. Butler, M.D.           72      CEO and President, International Longevity Center.   July 1989
                                         Professor of Geriatrics, Mount Sinai School of
                                         Medicine

Frank C. Carlucci                68      Chairman of the Board, Neurogen Corporation;         February 1989
                                         Chairman, The Carlyle Group

Jeffrey J. Collinson             57      President, Collinson Howe Venture Partners, Inc.     May 1989

Robert M. Gardiner               76      Senior Advisor, Morgan Stanley Dean Witter           June 1989

Mark Novitch, M.D.               66      Former Vice Chairman of the Board, The Upjohn        December 1993
                                         Company; Adjunct Professor of Health Care
                                         Sciences, George Washington University Medical
                                         Center

Harry H. Penner, Jr.             53      President and Chief Executive Officer, Neurogen      December 1993
                                         Corporation

Robert H. Roth, Ph.D.            59      Professor of Psychiatry and Pharmacology, Yale       December 1988
                                         University; member of the Scientific Advisory
                                         Board, Neurogen Corporation

John Simon                       56      Managing Director, Allen & Company Inc.              May 1989

John F. Tallman, Ph.D.           52      Executive Vice President, Secretary, Scientific      July 1988
                                         Director, and Chairman of the Scientific Advisory
                                         Board, Neurogen Corporation

Suzanne H. Woolsey, Ph.D.        57      Chief Operating Officer, National Academy of         January 1998
                                         Sciences/National Research Council
</TABLE>


<PAGE>
     Except as otherwise  noted  below,  the primary  form of  compensation  for
directors of the Company is the grant of stock  options  pursuant to the Program
(as defined  below).  Dr.  Roth also  receives a fee of $1,500 per month for his
services  as a director  and an  additional  $1,250 per month for service on the
Company's Scientific Advisory Board. Mr. Carlucci also receives an annual fee of
$50,000 for his services as Chairman of the Board.  Dr.  Bloom also  receives an
annual fee of $20,000 for  consulting  services  provided to the  Company.  Each
director of the Company  receives  out-of-pocket  travel  expenses in connection
with  his or  her  attendance  at  Board  meetings.  Pursuant  to  the  Neurogen
Corporation  1993  Non-Employee  Directors Stock Option Program (the "Program"),
every  non-employee  director  receives  an option to acquire  20,000  shares of
Common  Stock at its  then-current  fair market value upon the date of grant (an
"Initial Grant"). The current non-employee directors other than Dr. Woolsey were
granted such options on December 30, 1993,  (the  effective date of the adoption
of the  Program),  with an  exercise  price of $6.50 per share,  the fair market
value of the Common Stock on that date. Dr. Woolsey's  Initial Grant was made on
January  2, 1998,  the  effective  date of her  election  to the Board,  with an
exercise price of $14.00 per share, the fair market value of the Common Stock on
that date. Every future  non-employee  director will receive an Initial Grant as
of the  effective  date of such  director's  election  to the  board.  Under the
Program,  each  non-employee  director is granted  annually an option to acquire
5,000  shares of Common Stock on each  anniversary  of such  director's  Initial
Grant,  each with an exercise price equal to the fair market value of the Common
Stock on such  anniversary.  The current  non-employee  directors other than Dr.
Woolsey were  granted  such  options on December  30,  1994,  December 29, 1995,
December 31, 1996, and December 31, 1997 with exercise prices of $6.50, $26.875,
$19.25 and $13.50,  respectively,  the fair market  value of the Common Stock on
such dates.  The current  non-employee  directors,  including Dr. Woolsey,  were
granted such options on December 31, 1998 with an exercise price of $17.50,  the
fair  market  value  of the  common  stock  on that  date.  There  is no  family
relationship  between any  director,  executive  officer or person  nominated or
chosen by the Company to become a director or executive officer of the Company.

     Based  solely on its review of the forms  required by Section  16(a) of the
Securities Exchange Act of 1934, as amended (the "Exchange Act"), that have been
received by the Company,  the Company believes that all filing  requirements for
1998 applicable to its officers, directors and beneficial owners of greater than
ten percent of its Common Stock have been complied with.

     Harry H. Penner,  Jr., has been President,  Chief  Executive  Officer and a
director  of Neurogen  since  December  1993.  Mr.  Penner was  employed by Novo
Nordisk  A/S from 1981 to 1993,  most  recently  serving  as an  Executive  Vice
President of Novo Nordisk A/S and as President of Novo Nordisk of North  America
Inc. Mr. Penner holds an L.L.M.  in  International  Law from New York University
and a J.D.  from  Fordham  University.  Mr.  Penner  also serves on the Board of
Directors of Avant  Immunotherapeutics,  Inc.  (Needham,  MA), a publicly traded
biotechnology  company,  and PRA International,  Inc. (a privately held clinical
research  organization),  and  Genaissance  Pharmaceuticals,  a  privately  held
genomics  company.  Mr. Penner is currently  Co-Chairman of CURE,  Connecticut's
Bioscience  Cluster,  and  chaired  the Board of  Directors  of the  Connecticut
Technology  Council (CTC) from 1996 - 1998. In addition,  Mr. Penner serves as a
member  of the Board of  Directors  of the  Connecticut  Business  and  Industry
Association  (CBIA) and the  Emerging  Companies  Section  of the  Biotechnology
Industry Organization (BIO).

     Frank C.  Carlucci  has served as a director  and  Chairman of the Board of
Neurogen since February 1989. Mr.  Carlucci is principally  employed as Chairman
of The Carlyle Group, a private  merchant bank. Mr. Carlucci served as Secretary
of Defense of the United States from November 1987 through  January 1989.  Prior
to his  appointment as Secretary of Defense,  Mr.  Carlucci was assistant to the
President of the United States for National Security  Affairs.  Mr. Carlucci had
been Chairman and Chief Executive Officer of Sears World Trade Inc. from 1984 to
1986,  after having served as President and Chief Operating  Officer since 1983.
Mr.  Carlucci  is also a  director  of Ashland  Oil,  Inc.,  Kaman  Corporation,
Northern Telecom Limited,  The Quaker Oats Company,  Sun Resorts,  Pharmacia and
Upjohn Inc., Texas Biotech Inc. and IRI International.

     Barry M. Bloom,  Ph.D., has served as a director of Neurogen since December
1993.  Dr. Bloom  retired in 1993 from Pfizer where he had been  Executive  Vice
President,  Research and Development and a member of the board of directors. Dr.
Bloom is a director of Vertex  Pharmaceuticals,  Inc.,  Incyte  Pharmaceuticals,
Inc. and Cubist Pharmaceuticals, Inc.

     Robert N.  Butler,  M.D.,  has served as a director of Neurogen  since July
1989.  Dr.  Butler has served as the  Brookdale  Professor  and  Chairman of the
Department of Geriatrics  and Adult  Development  at Mount Sinai Medical  Center
since 1982.  From 1976 until 1982,  Dr. Butler was the founding  director of the
National Institute of Aging of the National Institutes of Health. Dr. Butler won
the 1976 Pulitzer Prize for his book, "Why Survive? Being Old in America". He is
the  editor-in-chief of Geriatrics,  a journal for primary care physicians,  and
serves on the editorial board of several other  professional  publications.  Dr.
Butler is presently Chief Executive  Officer and President of the  International
Longevity  Center-USA.  He is also a member of the  Institute of Medicine of the
National  Academy of Sciences and a founding  Fellow of the American  Geriatrics
Society. He has served as a consultant to the United States Special Committee on
Aging,  the National  Institute of Mental  Health,  the  Commonwealth  Fund, the
Brookdale Foundation and numerous other foundations and corporations.

     Jeffrey J.  Collinson has served as a director of Neurogen  since May 1989.
Mr. Collinson has served as President of Collinson Howe Venture Partners Inc., a
venture capital firm, since 1990 and was President of Schroder Venture Managers,
Inc., a venture  capital firm,  from 1981 to 1990. Mr.  Collinson is chairman of
the board of Incyte Pharmaceuticals, Inc.

     Robert M.  Gardiner  has served as a director of Neurogen  since June 1989.
Mr. Gardiner is currently a Senior Advisor to Morgan Stanley Dean Witter, having
retired  as  Chairman  and Chief  Executive  Officer  of Dean  Witter  Financial
Services  Group  Inc.  in August  1986.  Prior to  becoming  Chairman  and Chief
Executive  Officer in 1982,  Mr.  Gardiner  served as  President  of Dean Witter
Reynolds Inc., the predecessor of Dean Witter Financial  Services Group Inc. Mr.
Gardiner has served as Chairman and  President  of the National  Association  of
Securities Dealers, Inc., as Chairman of the Securities Industry Association and
of its  governing  council,  as Chairman of the National  Securities  Processing
Committee and as Vice Chairman of the New York Stock Exchange, Inc. He is also a
former  governor or officer of the  Association  of Stock  Exchange  Firms,  the
Investment Bankers  Association of America,  the National Clearing  Corporation,
the Central  Market System  Advisory  Committee of the  Securities  and Exchange
Commission, and the Securities Industry Association.  He is a former director of
Dean Witter, Discover & Co.

     Mark Novitch,  M.D.,  has served as a director of Neurogen  since  December
1993. Dr. Novitch was appointed  Professor of Health Care Sciences at The George
Washington University in 1994 and since 1997 has served as Adjunct Professor. He
worked in senior  executive  positions at The Upjohn Company from 1985 until his
retirement  as Vice  Chairman of the Board in 1993.  Dr.  Novitch  served at the
United States Food and Drug  Administration as Deputy Commissioner and as Acting
Commissioner from 1983-1984.  Dr. Novitch is a director of Alteon, Inc., Calypte
Biomedical, Inc., Guidant Corporation and KOS Pharmaceuticals, Inc.

     Robert H. Roth,  Ph.D., has served as a director of Neurogen since December
1988 and as a member of the Company's Scientific Advisory Board since July 1988.
Dr. Roth has been a Professor of Psychiatry and  Pharmacology at Yale University
since 1974. Dr. Roth has a Ph.D. in  Pharmacology  from Yale  University and has
published over 450 papers in the field of Neuropharmacology.

     John Simon has served as a director of Neurogen  since May 1989.  Mr. Simon
is a  Managing  Director  of the  investment  banking  firm of  Allen &  Company
Incorporated.  Mr. Simon is a director of Immune  Response  Corporation,  Realty
Information Group and Advanced Technical Products, Inc.

     John F. Tallman,  Ph.D.,  has been  Executive  Vice  President,  Scientific
Director,  Chairman of the Scientific  Advisory Board and a director of Neurogen
since July 1988. Dr. Tallman has served as Secretary of the Company since August
1994.  Prior to joining  Neurogen,  Dr.  Tallman was an  Associate  Professor of
Psychiatry  and  Pharmacology  at Yale  University  and  currently  serves as an
Adjunct  Professor in such  departments.  Dr. Tallman had  previously  served in
research  director  positions  at the  National  Institute  of Mental  Health in
Bethesda,  Maryland.  Dr. Tallman  received his Ph.D. in Biology from Georgetown
University.

     Suzanne H.  Woolsey,  Ph.D.,  has served as a director  of  Neurogen  since
January 1998.  Since 1993, Dr. Woolsey has served as Chief Operating  Officer of
the National  Academy of  Sciences/National  Research  Council,  an independent,
federally  chartered  policy  institution.  Prior to serving as Chief  Operating
Officer,  Dr.  Woolsey  served as the  Executive  Director of the  Commission on
Behavioral  and  Social  Sciences  and  Education  at the  National  Academy  of
Sciences/National  Research Council.  From 1980 to 1989, Dr. Woolsey served as a
Consulting  Partner  at Coopers  and  Lybrand,  an  accounting  firm,  where she
developed  and  directed  the  firm's   consulting   practice  with   healthcare
institutions,  research organizations, major research universities and corporate
general  counsels.  Dr. Woolsey holds a Ph.D. in clinical and social  psychology
from Harvard University.

Board Meetings and Committees

     The Board of Directors of the Company held five meetings  during the fiscal
year ended  December  31,  1998,  including  one special  meeting  conducted  by
telephone.  The  Board of  Directors  has an  Audit  Committee,  a  Compensation
Committee  and a Finance  Committee.  During the fiscal year ended  December 31,
1998, the Company did not have a nominating  committee or a committee performing
the functions of a nominating committee.

     The Audit Committee, which consists of Messrs. Carlucci, Novitch and Simon,
held one  meeting  in the last  fiscal  year.  The  Audit  Committee  recommends
appointment of the Company's  independent auditors and is primarily  responsible
for approving the services performed by the Company's  independent  auditors and
for reviewing and evaluating the Company's accounting  principles and its system
of internal accounting controls.

     The Compensation Committee,  which consists of Messrs.  Gardiner,  Carlucci
and Collinson,  held four meetings during the last fiscal year. The Compensation
Committee  reviews  and  makes  recommendations  to  the  Board  concerning  the
Company's executive and employee  compensation and stock option policy,  reviews
benefit  programs  and  determines  salaries for the  executive  officers of the
Company.

     The Finance Committee, which consists of Messrs. Gardiner, Collinson, Bloom
and Simon,  did not hold any  meetings  in the last  fiscal  year.  The  Finance
Committee  reviews  and  makes  recommendations  to the Board  concerning  major
finance  issues,  considers  possible  finance  ventures  with third parties and
monitors the Company's existing financial condition.

Certain Relationships and Related Transactions

     Pfizer Inc ("Pfizer"),  a beneficial owner of more than five percent of the
Common  Stock,   paid  $9.1  million  in  research   funding  and  made  certain
reimbursements  to the Company in the last fiscal year  pursuant to the terms of
various  collaborative  agreements  between  Pfizer and the Company which govern
their  research and  development  collaborations  with  respect to  anxiolytics,
hypnotics and cognition enhancers which act through the GABA family of receptors
and with respect to drugs which act through the  neuropeptide Y receptor  system
for the treatment of obesity.  These amounts  constituted  payments in excess of
five percent of Neurogen's consolidated gross revenues for the last fiscal year.
Neurogen   expects  to  receive  amounts  in  excess  of  five  percent  of  its
consolidated  gross revenues from Pfizer in fiscal year 1999. In connection with
these  collaborations  with Pfizer, the Company has granted Pfizer  registration
rights  with  respect  to shares of the  Company's  Common  Stock  purchased  in
connection with the collaborations as well as the right to maintain its level of
investment in the Company in future public offerings of Common Stock.

     In 1995, the Company made unsecured, non-interest bearing loans to Harry H.
Penner, Jr., its President and Chief Executive Officer,  and to John F. Tallman,
its Executive Vice President and Scientific Director,  of $200,000 and $150,000,
respectively. In 1994, the Company made an unsecured,  non-interest bearing loan
to Alan J. Hutchison,  its Vice President-Drug  Discovery, of $150,000. In 1997,
the Company made unsecured,  non-interest bearing loans to Stephen R. Davis, its
Vice  President-Finance  and Chief Financial Officer, to Kenneth R. Shaw, Senior
Vice  President  -  Chemistry  and  Pre-Clinical  Development,  and to  James V.
Cassella,  Vice  President - Clinical  Development  of $75,000 each. The largest
aggregate  amount  of  indebtedness  outstanding  at any time  during  1998 with
respect to each of Mr. Penner, Dr. Tallman,  Dr. Hutchison,  Mr. Davis, Dr. Shaw
and Dr. Cassella was $143,000,  $107,000, $86,000, $75,000, $75,000 and $75,000,
respectively.  See "Executive  Officers - Summary  Compensation Table" below for
information regarding forgiveness of indebtedness and forgiveness of interest on
indebtedness.


<PAGE>

                             PRINCIPAL STOCKHOLDERS

     The following  table sets forth, as of March 1, 1999,  certain  information
with respect to the beneficial ownership of Common Stock by each person known by
Neurogen to own  beneficially  more than five percent of its outstanding  Common
Stock,  by each  director  and  officer of  Neurogen  and by all  directors  and
officers as a group:
<TABLE>
<CAPTION>

<S>                                                         <C>                                   <C>   
Name and Address                                        Amount and Nature of               Approximate Percent
of Beneficial Owner                                    Beneficial Ownership(1)                    Owned(2)
- --------------------                                  -----------------------             ---------------------
Pfizer Inc...................................                2,846,000                            19.4%
   235 East 42nd Street
   New York, NY 10017
Biotechnology Value Fund.....................                1,626,706                            11.1%
   One Sansone Street
   San Francisco, CA  94104
Four Partners................................                1,638,500                            11.1%
   867 Madison Ave.
   New York, NY  10021
Franklin Resources Inc.......................                  793,000                             5.4%
   777 Mariners Island Blvd. 6th Floor
   San Mateo, CA  94404
Harry H. Penner, Jr. (3).....................                  468,327                             3.1%
John F. Tallman, Ph.D. (4)...................                  347,883                             2.3%
Alan J. Hutchison, Ph.D.(5)..................                  137,443                               *
Stephen R. Davis (6).........................                   88,257                               *
Kenneth R. Shaw (7)..........................                   71,850                               *
James V. Cassella(8).........................                   89,318                               *
Barry M. Bloom, Ph.D (9).....................                   38,089                               *
Robert N. Butler, M.D.(10)...................                   19,297                               *
Frank C. Carlucci(11)(13)....................                  146,414                             1.0%
Jeffrey J. Collinson(9)(12)..................                   72,101                               *
Robert M. Gardiner(9)........................                   72,089                               *
Mark Novitch, M.D.(13).......................                   41,089                               *
Robert H. Roth, Ph.D.(14)....................                   86,089                               *
John Simon(13)(15)...........................                   70,593                               *
Suzanne Woolsey(16)..........................                    9,591                               *
All directors and officers
   as a group (15 persons)(17)...............                1,758,430                           11.1%
</TABLE>

- -----------------------
 *     Less than one percent (1%).

(1)  Share  ownership in each case  includes  shares  issuable  upon exercise of
     outstanding  common stock  options  exercisable  within 60 days of March 1,
     1999.

(2)  Percentage  of  the  outstanding  shares  of  Common  Stock,   treating  as
     outstanding for each beneficial owner all shares of Common Stock which such
     beneficial owner has indicated are issuable under stock options exercisable
     within 60 days of March 1, 1999.

(3)  Includes  422,000 shares of Common Stock that Harry H. Penner,  Jr. has the
     right to acquire  under stock options  exercisable  within 60 days of March
     1,1999,   and  30,000   restricted   shares  subject  to  certain   vesting
     requirements  relating to the performance of the Company's shares of Common
     Stock.

(4)  Includes 169,000 shares of Common Stock that John F. Tallman, Ph.D. has the
     right to acquire under stock options exercisable within 60 days of March 1,
     1999, and 22,500 restricted shares subject to certain vesting  requirements
     relating to the performance of the Company's  shares of Common Stock.  Does
     not include  2,000  shares of Common  Stock owned by Kathleen  Person,  Dr.
     Tallman's  spouse.  Kathleen  Person and Dr.  Tallman  disclaim  beneficial
     ownership of each other's shares.

(5)  Includes 118,000 shares of Common Stock that Alan J. Hutchison,  Ph.D., has
     the right to acquire  under  stock  options  exercisable  within 60 days of
     March 1, 1999 and 18,750  restricted  shares  subject  to  certain  vesting
     requirements  relating to the performance of the Company's shares of Common
     Stock.

(6)  Includes  71,250 shares of Common Stock that Stephen R. Davis has the right
     to acquire under stock options exercisable within 60 days of March 1, 1999,
     and  15,750  restricted  shares  subject to  certain  vesting  requirements
     relating to the performance of the Company's shares of Common Stock.

(7)  Includes 56,850 shares of Common Stock that Kenneth R. Shaw, Ph.D., has the
     right to acquire under stock options exercisable within 60 days of March 1,
     1999, and 15,000 restricted shares subject to certain vesting  requirements
     relating to the performance of the Company's shares of Common Stock.

(8)  Includes  79,350 shares of Common Stock that James V.  Cassella,  Ph.D. has
     the right to acquire  under  stock  options  exercisable  within 60 days of
     March 1,  1999 and 9,375  restricted  shares  subject  to  certain  vesting
     requirements  relating to the performance of the Company's shares of Common
     Stock.

(9)  Includes 17,089 shares of Common Stock subject to stock options exercisable
     within 60 days of March 1, 1999.

(10) Includes 19,297 shares of Common Stock subject to stock options exercisable
     by Robert N. Butler, M.D., within 60 days of March 1, 1999.

(11) Does not include  40,000  shares of Common  Stock  owned by Mr.  Carlucci's
     wife.  Mr.  Carlucci  and his wife  disclaim  beneficial  ownership of each
     other's shares.

(12) Includes 23,500 shares of Common Stock held by Schroder's Incorporated, for
     which Mr.  Collinson  acts as  attorney-in-fact  and shares  investment and
     voting power, and 3,880 shares of Common Stock held by a corporation  which
     Mr. Collinson controls.

(13) Includes 37,089 shares of Common Stock subject to stock options exercisable
     within 60 days of March 1, 1999.

(14) Includes 44,089 shares of Common Stock subject to stock options exercisable
     by Robert H. Roth, Ph.D. within 60 days of March 1, 1999.

(15) Does  not  include   shares  of  Common  Stock  held  by  Allen  &  Company
     Incorporated  and  by  persons  and  entities  which  may be  deemed  to be
     affiliated  with Allen & Company  Incorporated,  of which  shares Mr. Simon
     disclaims beneficial ownership.

(16) Includes 9,591 shares of Common Stock subject to stock options  exercisable
     within 60 days of March 1, 1999.

(17) Includes  1,151,961  shares  of  Common  Stock  subject  to  stock  options
     exercisable within 60 days of March 1, 1999.


<PAGE>



                               EXECUTIVE OFFICERS

     In addition to Mr. Penner and Dr.  Tallman (See  "Election of  Directors"),
the other executive  officers of the Company who are elected by and serve at the
discretion of the Board of Directors, are as follows:
<TABLE>
<CAPTION>

<S>                          <C>                        <C>                                    <C>    
Name                         Age           Position                                         Officer Since
- -------                     ----           ------------                                     -------------

James V. Cassella.........   44            Vice President - Clinical Development             April 1999

Stephen R. Davis..........   38            Vice President-Finance, CFO, Treasurer            July 1994
                                           and General Counsel

Alan J. Hutchison.........   45            Senior Vice President-Drug Discovery              June 1994

Kenneth R. Shaw ..........   42            Senior Vice President - Chemistry and             April 1999
                                           Pre-Clinical Development
</TABLE>

     James  V.Cassella  joined  Neurogen in 1989 and has served in various roles
including his current  position of Vice  President of Clinical  Development  and
Director of Behavioral Biology.  Prior to joining Neurogen,  Dr. Cassella was an
Assistant  Professor of Neuroscience at Oberlin College.  Dr. Cassella  received
his Ph.D. in Psychology from Dartmouth  College in 1983 and subsequently  held a
Postdoctoral  Fellowship in the  Department  of Psychiatry at Yale  University's
School of Medicine.

     Stephen R. Davis has been Vice  President-Finance,  Chief Financial Officer
and  Treasurer  of  Neurogen  since July 1994.  In 1998 Mr.  Davis  assumed  the
additional role of General  Counsel.  Prior to joining  Neurogen,  Mr. Davis was
employed  by  Milbank,  Tweed,  Hadley & McCloy as a  corporate  and  securities
attorney.  Previously, Mr. Davis practiced as a Certified Public Accountant with
Arthur  Andersen & Co. Mr. Davis  received his B.S. in Accounting  from Southern
Nazarene University and a J.D. degree from Vanderbilt University.

     Alan J. Hutchison, Ph.D., has been Vice President-Drug Discovery since 1992
and a member of Neurogen's  Scientific  Advisory Board since 1989. Dr. Hutchison
joined  Neurogen in 1989 as Director of Chemistry.  From 1981 through 1989,  Dr.
Hutchison was employed by Ciba Giegy, most recently as a Distinguished  Research
Fellow.  Dr. Hutchison  received his B.S. in Chemistry from Stevens Institute of
Technology and received his Ph.D. from Harvard University.

     Kenneth R. Shaw  joined  Neurogen  in 1989 and has served in various  roles
including  his current  position  of Senior  Vice  President  of  Chemistry  and
Pre-Clinical  Development.  Dr. Shaw began his career in 1983 at Ciba-Geigy as a
Senior  Scientist  and also spent 2 years as  Scientific  Director  at  Franklin
Diagnostics.  Dr.  Shaw  received a B.S. in  Chemistry  from the  University  of
Rochester in 1979, and a Ph.D. in Organic Chemistry from Columbia  University in
1983.


                      Compensation of Executive Officers 1

Compensation Committee Report:

    The Compensation  Committee of the Board of Directors  consists  entirely of
outside   directors.   The  Committee  is  responsible  for   establishing   and
administering  the  policies  which  govern both annual  compensation  and stock
ownership programs of the Company.  On an annual basis, the Committee  evaluates
the performance of management and determines the  compensation of Mr. Penner and
the other  executive  officers of the  Company.  The  Committee's  policies  and
programs are designed to further the Company's  goal of  increasing  shareholder
value by motivating and retaining executive officers. These policies include the
following objectives:

            o    Providing base salaries that take into consideration  executive
                 compensation  paid by other  similar  biotechnology  companies.
                 Peer  companies   generally  are  at  a  comparable   stage  of
                 development, are pursuing R&D programs of comparable nature and
                 complexity and have similar potential risks and rewards, market
                 capitalization,  size and financial  condition.  This objective
                 also takes into  account  the  competitive  demand for  quality
                 personnel in the pharmaceutical  and biotechnology  industries,
                 individual  experience  and specific  issues  particular to the
                 Company.

            o    Providing  periodic  bonus awards for completion of significant
                 achievements or attainment of significant objectives.

            o    Providing  equity  participation in the form of grants of stock
                 options  and  restricted  stock  for the  purpose  of  aligning
                 executive  officers'  longer term  interests  with those of the
                 shareholders.

    In the biotechnology industry traditional measures of corporate performance,
such as earnings per share or sales  growth,  may not readily apply in reviewing
performance  of  executives.   Rather,   at  the  Company's   current  stage  of
development,  in determining the  compensation  of the Company's  executives the
Compensation  Committee  looks to other  measures  of  performance,  such as the
progress of the  Company's  research  and  development  programs  and  corporate
development activities, the establishment and maintenance of strategic corporate
alliances and the Company's success in securing capital sufficient to assist the
Company in  advancing  and  expanding  its product  development,  including  the
funding of clinical trials. The Committee believes that outstanding  performance
in these areas will  contribute to the long-term  success of the Company and the
growth  of  shareholder   value.  The  Committee   specifically   considers  the
achievement  of milestones  related to expansion of the  Company's  portfolio of
drug development  programs,  the development of multiple drug candidates  within
individual  programs  and the  progress of  individual  candidates  in each such
program. In addition,  the Committee considers the extent to which the Company's
shares have changed in value.  However,  the Compensation  Committee  recognizes
that,  in the  short-term,  the  market  price of the  Company's  shares  may be
affected by the inherently unpredictable nature of drug development and industry
events  and  market  conditions  which are  transient  in nature  and beyond the
control of management.  This is especially true in the  biotechnology  industry,
which is characterized by long product lead times, the iterative trial and error
nature  of drug  development,  highly  volatile  stock  prices  and  fluctuating
availability of capital.  Accordingly,  the Compensation  Committee  attempts to
retain and  appropriately  motivate the  Company's  executives  by balancing the
consideration of shorter-term  strategic goals with longer-term objectives which
are essential in creating maximum shareholder value.

    In  many  instances  the  qualitative  factors  by  which  the  Compensation
Committee  judges  corporate   performance   necessarily  involve  a  subjective
assessment by the Committee of management's performance. Moreover, the Committee
does not base its  considerations on any single  performance  factor nor does it
specifically  assign relative weights to factors,  but rather considers a mix of
factors and evaluates Company and individual performance against that mix.

    Compensation paid by the Company to its executive officers is designed to be
competitive  with  compensation  packages  paid to the  management of comparable
companies  in the  biotechnology  industry.  Toward that end,  the  Compensation
Committee  may  review   independent  survey  data  as  well  as  data  gathered
internally, and may obtain the counsel of expert compensation consultants. Total
compensation  for  the  Company's  executive  officers  includes  a base  salary
component and may also include other forms of incentives. Incentive compensation
may  consist of cash  incentive  bonuses  based on  satisfying  corporate  goals
established  for  the  year  as  well  as  on  meeting  individual   performance
objectives. In addition, executive officers of the Company may receive incentive
compensation  under the Neurogen  Corporation  1993 Omnibus  Incentive Plan (the
"Incentive  Plan") such as grants of options to purchase shares of the Company's
Common  Stock,  with exercise  prices  typically set at fair market value on the
date of grant or grants of restricted  stock which may have certain  performance
criteria.  Executive  compensation  may also include loans,  which are typically
forgiven over a period of five to seven years,  provided the  recipient  remains
employed by the Company during such period.

    Executive  officers are eligible for grants of stock options and  restricted
stock as an element of their total annual compensation  package.  This component
is intended to motivate and retain executive officers to improve long-term stock
performance.  Stock  option  and  restricted  stock  awards  are  granted at the
discretion of the Compensation Committee. Generally, stock options vest in equal
amounts over four or five years, have a ten year term and are exercisable during
the term of the option at the fair market value of the  underlying  Common Stock
on the date of grant. As with cash bonuses,  the number of options to be granted
to each executive  officer is based on the degree of attainment of predetermined
Company and individual  objectives,  with emphasis,  in certain cases,  on those
which have long-term strategic value. The Company generally grants stock options
to all  employees and uses stock options as a bonus  vehicle.  The  Compensation
Committee  administers  the Incentive  Plan.  For 1998, all six of the Company's
executive  officers  received  under the Incentive  Plan stock option awards and
grants of restricted stock ("Earned  Restricted  Stock") which will vest only if
the Company's  common stock achieves the performance  criteria  described below.
Earned  Restricted  Stock is  non-transferable  unless  and until the  Company's
common  stock  reaches a market  price of $45 per share within four (4) years of
the date of grant.  If the common  stock fails to reach the target  price within
this time frame the  shares of Earned  Restricted  Stock  will be  automatically
forfeited.

    The Company made  significant  progress in meeting most of it's goals during
the fiscal year ended December 31, 1998. The Compensation  Committee  considered
the  following  developments  in 1998 in  establishing  the base salaries of the
executive officers for fiscal year 1999 and in awarding  incentive  compensation
based on the  Company's  performance  in 1998:  the  progress of human  clinical
trials  for  the  Company's   anti-anxiety   drug   candidate,   NGD  91-2,  the
identification and advancement of an additional  candidate for human trials, NGD
91-3;  the  pre-clinical   development  of  the  Company's   anti-insomnia  drug
candidate,   NGD  96-1,  in  preparation  for  human  clinical  trials  and  the
identification  and  advancement of additional  drug  candidates,  including NGD
96-2, in the Company's anti-insomnia collaboration with Pfizer; the pre-clinical
development of the Company's cognition enhancement drug candidate,  NGD 97-1, in
preparation for human clinical  trials;  the  identification  and advancement of
pre-clinical  candidates  in the Company's NPY program to develop drugs to treat
obesity and the extension of the Company's  joint  research  collaboration  with
Pfizer for this  program;  the  advancement  of a new series of compounds in the
Company's CRF stress disorder  program and the development of the Company's lead
compound in this program, NGD 98-1; and the further advancement of the Company's
proprietary  AIDD drug discovery  program and the application of this technology
to discover  drug  candidates  in new areas,  thereby  expanding  the  Company's
portfolio of drug development programs. The Compensation Committee believes that
the commitment and leadership of the Company's executive officers were important
factors in the Company's achievements in fiscal 1998.

    The  Compensation  Committee  reviewed  the  Company's  performance  and the
performance of the Company's executive officers during fiscal 1998, to determine
cash incentive bonuses and stock option grants to such executive officers and to
set base salary levels for fiscal 1999. The Compensation Committee also retained
the services of a compensation  consulting firm to assist it in its review.  Mr.
Penner  was not  present  during the  Compensation  Committee's  discussion  and
determination of his compensation.  In recognition of the achievement of Company
and  individual  performance  criteria  outlined  above and after  reviewing the
compensation  levels of officers at peer companies,  the Compensation  Committee
approved  increases in the base salaries of, and awarded cash incentive bonuses,
stock option and Earned Restricted Stock to each executive officer including Mr.
Penner whose  compensation is further described below. The 1999 base salaries of
the named  executive  officers as a group have been  increased  by an average of
15.6 percent over 1998 base salaries.  These increases were made in January 1999
and reflected  the  Committee's  review,  aided by the  compensation  consultant
retained by the Committee,  of the compensation levels of the Company's officers
in relation to the compensation levels of officers at peer companies.

    In  evaluating  the  compensation  of Harry H. Penner,  Jr.,  the  Committee
considered  the  significant  role Mr.  Penner played in each of the above noted
accomplishments. The Compensation Committee raised Mr. Penner's base salary from
$357,000 to $394,000,  effective December 1, 1998, and awarded Mr. Penner a cash
bonus of $116,000 or 32 percent of his base salary. As additional recognition of
Mr. Penner's efforts in 1998, and in furtherance of the Committee's  belief that
a substantial  portion of Mr. Penner's total compensation should be dependent on
the  long-term  appreciation  of the  Company's  stock  price,  in December  the
Committee  granted Mr. Penner 30,000  shares of Earned  Restricted  Stock and an
option to  purchase  45,000  shares of  Neurogen  Common  Stock  pursuant to the
Incentive Plan. Mr. Penner's salary increase and awards reflect the Compensation
Committee's assessment of his very favorable performance and his contribution to
the Company's achievement of significant milestones.

By the  Compensation  Committee:  Frank C. Carlucci,  and Jeffrey J.  Collinson,
Robert M. Gardiner and John Simon.

- -------------------
1    This Section is not  "soliciting  material," is not deemed "filed" with the
     SEC and is not to be incorporated by reference in any filing of the Company
     under the Securities Act of 1933, as amended (the "Securities Act"), or the
     Exchange Act, whether made before or after the date hereof and irrespective
     of any general incorporation language in any such filing.
<PAGE>

     For the three years ended  December 31, 1998,  1997,  and 1996, the Company
paid the  amounts  shown in the  following  table  with  respect  to each of the
executive officers of the Company:

                           Summary Compensation Table
                                                                            
<TABLE>
<CAPTION>
                                                                                   Long-Term
                                                Annual                            Compensation
                                              Compensation                           Awards
                            -----------------------------------------  -------------------------------
<S>                         <C>       <C>     <C>          <C>                <C>             <C>
                                                            Other        Securities       All Other
                                                            Annual       Underlying        Compen-
Name and Principal          Salary   Year      Bonus     Compensation    Options (a)        sation
Position                      ($)               ($)           ($)            (#)              ($)
- ------------------         -------   ----     -------    ------------   -------------     -----------
Harry H. Penner, Jr.       358,417   1998     116,000     41,939 (b)        45,000          8,672(c)
President and Chief        340,000   1997     136,000     45,206 (d)        80,000(m)       8,636(c)
Executive Officer          311,583   1996     122,000     41,605 (e)        80,000          9,586(c)

John F. Tallman            226,917   1998      60,000     31,455 (f)        22,500          5,792(c)
Executive Vice-President   215,000   1997      80,000     33,904 (g)        60,000          5,752(c)
President, Scientific      201,250   1996      70,000     31,205 (h)        60,000(m)       5,772(c)
Director and Secretary                                          

Alan J. Hutchison          216,792   1998      54,000     28,926 (i)        18,750          4,418(c)
Vice President-Drug        193,500   1997      70,000     31,493 (j)        50,000          3,877(c)
Discovery                  180,000   1996      40,000     47,387 (k)        40,000(m)       3,029(c)
 
Stephen R. Davis           181,025   1998      40,000     18,148 (l)        15,750          3,741(c)
Vice President-Finance,    167,700   1997      45,000      7,639 (n)        25,000          3,705(c)
CFO, Treasurer, and        156,000   1996      39,000      6,222 (o)        25,000(m)       3,796(c)
General Counsel                                                  

Kenneth R. Shaw            158,250   1998      40,000     18,148 (p)        15,000            714(c)
Senior Vice President      150,625   1997      40,000      1,528 (q)        25,000(m)         714(c)
Chemistry and Pre-         136,500   1996      39,000         -             25,000            714(c)
Clinical Development

James V. Cassella          158,250   1998      35,000     18,148 (p)         9,375          3,914(c)
Vice-President -           150,625   1997      40,000      1,528 (q)        25,000          3,877(c)
Clinical Development       136,500   1996      39,000         -             25,000(m)       3,714(c)

</TABLE>
- --------------------

(a)  References to SARs in the Summary  Compensation  Table and all other tables
     in this Proxy  Statement  have been  omitted,  since the  Company has never
     issued SARs, although under the Neurogen Corporation 1993 Omnibus Incentive
     Plan it has the ability to do so.
(b)  Includes $28,571 of forgiveness of loan,  forgiveness of interest of $7,279
     on loan and income tax reimbursements of $6,089.
(c)  Includes premiums for life insurance,  and matching  contribution  received
     from participation in the Company's 401(k) plan.
(d)  Includes $28,571 of forgiveness of loan,  forgiveness of interest of $9,058
     on loan and income tax reimbursements of $7,577.
(e)  Includes $28,571 of forgiveness of loan,  forgiveness of interest of $7,097
     on loan and income tax reimbursements of $5,937.
(f)  Includes $21,429 of forgiveness of loan,  forgiveness of interest of $5,459
     on loan and income tax reimbursements of $4,567.
(g)  Includes $21,429 of forgiveness of loan,  forgiveness of interest of $6,793
     and income tax reimbursements of $5,683.
(h)  Includes $21,429 of forgiveness of loan,  forgiveness of interest of $5,323
     on loan and income tax reimbursements of $4,453.
(i)  Includes $21,429 of forgiveness of loan,  forgiveness of interest of $4,082
     on loan and income tax reimbursements of $3,415.
(j)  Includes $21,429 of forgiveness of loan,  forgiveness of interest of $5,480
     and income tax reimbursements of $4,584.
(k)  Includes forgiveness of loan of $21,429,  forgiveness of interest of $4,373
     on loan and income tax reimbursement of $21,585.
(l)  Includes $10,714 of forgiveness of loan,  forgiveness of interest of $4,048
     on loan and income tax reimbursements of $3,386.
(m)  With respect to twenty-five percent of the year-end 1997 options granted to
     the Company's  executive  officers,  the exercise price for any unexercised
     options may drop to zero at the end of the ten year term of the option, but
     only if the  officer has  remained  employed by the Company for a period of
     seven years from the date of grant.
(n)  Includes  $5,000 of forgiveness of loan,  forgiveness of interest of $1,437
     and income tax reimbursement of $1,202.
(o)  Includes forgiveness of loan of $5,000,  forgiveness of interest of $665 on
     loan and income tax reimbursements of $557.
(p)  Includes $10,714 of forgiveness of loan,  forgiveness of interest of $4,048
     on loan and income tax reimbursement of $3,386.
(q)  Includes   forgiveness   of  interest  of  $832  on  loan  and  income  tax
     reimbursement of $696.
<PAGE>

     For the year ended  December  31,  1998,  the  following  tables  summarize
incentive compensation paid to executive officers:

                        Option Grants in Last Fiscal Year

<TABLE>
<CAPTION>

<S>                           <C>            <C>                 <C>            <C>            <C>    
                             Number of                                                    
                             Securities       % of Total                                   Potential Realizable Value at
                             Underlying    Options Granted     Exercise                    Assumed Annual Rates of Stock
                              Options      to Employees in      Price       Expiration       Price Appreciation for             
    Name                      Granted        Fiscal Year      ($/Share)        Date                Option Term
- -----------                -----------     ---------------    ----------   ------------    ------------------------------
                                                                                               5%($)           10%($)
                                                                                               -----           ------

Harry H. Penner, Jr.          45,000 *           10%             17.50        12/31/08        $495,255        $1,255,072
John F. Tallman               22,500 *            5%             17.50        12/31/08         247,627           627,536
Alan J. Hutchison             18,750 *            4%             17.50        12/31/08         206,356           522,947
Stephen R. Davis              15,750 *            3%             17.50        12/31/08         173,339           439,275
Kenneth R. Shaw               15,000 *            3%             17.50        12/31/08         165,085           418,357
James V. Cassella              9,375 *            2%             17.50        12/31/08         103,178           261,473

- --------------------
</TABLE>

* Stock options vest in equal  amounts over four or five years,  have a ten year
term and are exercisable  during the term of the option at the fair market value
of the underlying Common Stock on the date of grant.



             Long-Term Incentive Plans - Awards in Last Fiscal Year
<TABLE>
<CAPTION>

<S>                                       <C>                            <C>    
                                      Number of Shares of
                                       Restricted Stock            Performance Period Until
Name                                        (#)                    Maturation or Payout
- -----------                           -------------------        --------------------------  
Harry H. Penner, Jr.                       30,000 *                        12/31/03
John F. Tallman                            22,500 *                        12/31/03
Alan J. Hutchison                          18,750 *                        12/31/03
Stephen R. Davis                           15,750 *                        12/31/03
Kenneth R. Shaw                            15,000 *                        12/31/03
James V. Cassella                           9,375 *                        12/31/03
- --------------------
</TABLE>

* Restricted  Stock is  non-transferable  unless and until the Company's  common
stock  reaches a market price of $45 per share within four (4) years of the date
of grant.  If the common  stock fails to reach the target price within this time
frame the shares of Restricted Stock will be automatically forfeited.




<PAGE>



                 Aggregated Option Exercises in Last Fiscal Year
                        and Fiscal Year-End Option Values
<TABLE>
<CAPTION>

<S>                         <C>             <C>          <C>                             <C>    

                                                           Number of Securities
                                                          Underlying Unexercised            Value of Unexercised
                              Shares         Value           Options at Fiscal            In-the-Money Options at
                           Acquired on      Realized             Year-End                  Fiscal Year-End ($)(a)
Name                        Exercise (#)     ($) (a)     Exercisable/Unexercisable        Exercisable/Unexercisable
- -------                   ------------     ---------     -------------------------        -------------------------

Harry H. Penner, Jr.            -              -               422,000/213,000              $3,502,000/$428,000
John F. Tallman                 -              -               169,000/148,500              $1,009,850/$321,000
Alan J. Hutchison               -              -               118,000/110,750               $722,000/$248,000
Stephen R. Davis                -              -                71,250/75,750                $413,750/$211,250
Kenneth R. Shaw               7,500          89,063             56,850/67,500                $274,100/$135,000
James V. Cassella               -              -                79,350/61,875                $521,600/$135,000
- ---------------------
</TABLE>

(a)  Difference  between  option  price and fair  market  value of the shares at
     year-end.

Terms and Conditions of Certain Employment and Severance Agreements

     The compensation  package for Harry H. Penner,  Jr., as President and Chief
Executive  Officer,  includes a salary paid pursuant to an employment  agreement
between Mr. Penner and the Company  which was entered into in October 1993.  The
agreement  was scheduled to expire on November 30, 1997,  but was  automatically
extended for an  additional  two-years  pursuant to the terms of the  agreement.
Under such agreement, Mr. Penner's base salary of $357,000 per annum in 1998 was
increased to $394,000  effective  December 1, 1998.  Such  increase was, and any
future  increases  will be, at the  discretion  of the Board of  Directors.  The
employment  agreement  provides for the  continuation of Mr. Penner's salary and
benefits  under  certain  severance  conditions  and  restricts  Mr. Penner from
competing with the Company for the term of the agreement and for a period of one
year after termination of his employment with the Company.

     The compensation  package for John F. Tallman,  as Executive Vice President
and  Scientific  Director of  Neurogen,  includes a salary  paid  pursuant to an
employment  agreement between Dr. Tallman and the Company which was entered into
in June 1994.  The agreement  was scheduled to expire on November 30, 1997,  but
was automatically  extended for an additional two-years pursuant to the terms of
the agreement.  Under such agreement,  Dr. Tallman's base salary of $226,000 per
annum in 1998 was  increased  to  $257,000  effective  December  1,  1998.  Such
increase was, and any future  increases  will be, at the discretion of the Board
of Directors.  The employment  agreement  provides for the  continuation  of Dr.
Tallman's salary and benefits under certain  severance  conditions and restricts
Dr.  Tallman from  competing  with the Company for the term of the agreement and
for a period of one year after termination of his employment with the Company.

     The compensation package for Alan J. Hutchison,  as Senior Vice President -
Drug  Discovery  of  Neurogen,  includes a salary  paid  pursuant  to a two-year
renewable  employment  agreement between Dr. Hutchison and the Company effective
December 1, 1998. Under such agreement,  Dr. Hutchison's base salary of $215,000
per annum in 1998 was  increased to $244,000  effective  December 1, 1998.  Such
increase was, and any future  increases  will be, at the discretion of the Board
of Directors.  The employment  agreement  provides for the  continuation  of Dr.
Hutchinson's  salary  and  benefits  under  certain  severance   conditions  and
restricts  Dr.  Hutchison  from  competing  with the Company for the term of the
agreement and for a period of one year after  termination of his employment with
the Company.

     The compensation package for Stephen R. Davis, Vice President - Finance and
Chief  Financial  Officer of  Neurogen,  includes a salary  paid  pursuant  to a
two-year  renewable  employment  agreement  between  Mr.  Davis and the  Company
effective  December 1, 1998.  Under such  agreement,  Mr.  Davis' base salary of
$180,000 per annum in 1998 was increased to $215,000 effective December 1, 1998.
Such increase was, and any future  increases  will be, at the  discretion of the
Board of Directors.  The employment  agreement  provides for the continuation of
Mr. Davis's salary and benefits under certain severance conditions and restricts
Mr. Davis from  competing with the Company for the term of the agreement and for
a period of one year after termination of his employment with the Company.

<PAGE>
                               PERFORMANCE GRAPH 2


     The  following  graph  compares  the  yearly  percentage  in the  Company's
cumulative  total  stockholder  return  on its  Common  Stock  during  a  period
commencing  on December  31, 1993 and ending  December  31, 1998 (as measured by
dividing  (i)  the  sum of (A)  the  cumulative  amount  of  dividends  for  the
measurement  period,  assuming  dividend  reinvestment,  and (B) the  difference
between the Company's share price at the end and the beginning of the period; by
(ii) the share at the beginning of the period) with the cumulative return of the
NASDAQ Stock Market Index (U.S. and Foreign) and the Amex  Biotechnology  Index.
It should be noted that Neurogen has not paid dividends on Common Stock,  and no
dividends are included in the representation of the Company's  performance.  The
stock price  performance  on the graph below is not  necessarily  indicative  of
future price performance.

<TABLE>
<CAPTION>
<S>            <C>            <C>            <C>    
                               Nasdaq                                                
                               Total           Amex
Date            Neurogen       Market         Biotech 
- ------         ----------     --------       ---------
12/31/93         100.0          100.0          100.0          
12/31/94          98.1           97.0           70.9
12/31/95         405.7          136.2          115.5     
12/31/96         290.6          166.8          124.6
12/31/97         203.8          204.1          140.3
12/31/98         264.2          281.8          159.9


</TABLE>
- --------------
2    This Section is not  "soliciting  material," is not deemed "filed" with the
     SEC and is not to be incorporated by reference in any filing of the Company
     under the Securities Act of 1933, as amended (the "Securities Act"), or the
     Exchange Act, whether made before or after the date hereof and irrespective
     of any general incorporation language in any such filing.






<PAGE>





                                 PROPOSAL NO. 2:
                         RATIFICATION OF APPOINTMENT OF
                              INDEPENDENT AUDITORS

     The Board of Directors has selected PricewaterhouseCoopers LLP, independent
certified public accountants,  as auditors to audit the financial  statements of
the Company  for the year  ending  December  31,  1999 and  recommends  that the
stockholders  ratify  such  selection.  PricewaterhouseCoopers  LLP  audited the
Company's  annual  financial  statements  for the fiscal year ended December 31,
1998.

     Stockholder ratification of the selection of PricewaterhouseCoopers  LLP as
the Company's  independent  auditor is not required by the Company's  by-laws or
otherwise.    However,    the   Board   is    submitting    the   selection   of
PricewaterhouseCoopers  LLP to the  stockholders for ratification as a matter of
good corporate practice.  If the stockholders fail to ratify the selection,  the
Board will  reconsider  whether or not to retain the firm. Even if the selection
is ratified, the Board, or the Audit Committee acting on behalf of the Board, in
its  discretion  may direct the  appointment  of a different firm of independent
auditors at any time if the Board, or the Audit Committee,  determines that such
a change would be in the best interests of the Company and its stockholders.

     Representatives of PricewaterhouseCoopers LLP are expected to be present at
the Annual Meeting with the opportunity to make a statement if they desire to do
so, and are expected to be available to respond to appropriate questions.

     The Board of Directors recommends a vote FOR approval of this proposal.  If
not otherwise specified, proxies will be voted FOR approval.


                     SHAREHOLDER PROPOSALS AND OTHER MATTERS

    The  Board of  Directors  of the  Company  knows of no other  matters  to be
submitted to the Annual Meeting.  If any other matters  properly come before the
Annual Meeting, it is the intention of the persons named in the enclosed form of
proxy  to vote the  shares  of  Common  Stock  they  represent  as the  Board of
Directors may  recommend.  Anyone  desiring to address the  stockholders  at the
Annual Meeting,  whether or not making a formal proposal,  must so indicate this
intention to the Secretary of the Company prior to the Annual Meeting.

    In order to be considered  for inclusion in the Proxy  Statement and form of
proxy  relating to the 2000 Annual  Meeting of  Stockholders,  any proposal by a
stockholder  of record of the  Company  must be  received  by the Company at its
principal executive offices in Branford, CT on or before December 20, 1999.

     THE COMPANY WILL MAIL WITHOUT CHARGE TO EACH  STOCKHOLDER  ENTITLED TO VOTE
AT THE ANNUAL  MEETING  UPON WRITTEN  REQUEST,  A COPY OF THE  COMPANY'S  ANNUAL
REPORT ON FORM 10-K, INCLUDING THE FINANCIAL STATEMENTS, SCHEDULES AND A LIST OF
EXHIBITS, AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION. WRITTEN REQUESTS
SHOULD BE SENT TO:  CORPORATE  SECRETARY,  NEUROGEN  CORPORATION,  35  NORTHEAST
INDUSTRIAL ROAD, BRANFORD, CONNECTICUT 06405.

                                                  JOHN F. TALLMAN
                                                  Secretary
                                           

April 26, 1999
<PAGE>




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