NEUROGEN CORP
3, 1999-03-16
PHARMACEUTICAL PREPARATIONS
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                UNITED STATES SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                     FORM 3

             INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

         Filed pursuant to Section 16(a) of the Securities Exchange Act
   of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

(Print or Type Responses)

1.   Name and Address of Reporting Person:

                    Thomas J. Tisch
                    667 Madison Avenue
                    New York, NY 10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  3/5/99

3.   I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4.   Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5.   Relationship of Reporting Persons(s) to Issuer:

                  ___  Director
                  ___  Officer (give title below)
                  _X_  10% Owner
                  ___  Other (specify below)


<PAGE>


6.   If Amendment, Date of Original (Month/Day/Year)



7.   Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person

             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  409,625

3.   Ownership Form:  Direct (D) or Indirect (I)

                  I

4.   Nature of Indirect Beneficial Ownership

                  (See explanation)


               Table II - Derivative Securities Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)


1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date




                                       2

<PAGE>


3.   Title and Amount of Securities Underlying Derivative Security

         Title



         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

Explanation of Responses:

              This Form 3 is being filed jointly by the following individuals
         and entities:

              1. Thomas J. Tisch;

              2. Daniel R. Tisch;

              3. James S. Tisch;

              4. Andrew H. Tisch (Thomas J. Tisch, Daniel R. Tisch, James S.
         Tisch and Andrew H. Tisch are referred to collectively as the "Messrs.
         Tisch");

              5. Four-Fourteen Partners, LLC, a Delaware limited liability
         company ("4-14P");

              6. The Thomas J. Tisch 1999 Annuity Trust II ("Thomas Tisch GRAT
         II");

              7. The Daniel R. Tisch 1999 Annuity Trust II ("Daniel Tisch GRAT
         II");

              8. The James S. Tisch 1999 Annuity Trust II ("James Tisch GRAT
         II"); and




                                       3

<PAGE>

              9. The Andrew H. Tisch 1999 Annuity Trust II ("Andrew Tisch GRAT
         II"; and collectively with Thomas Tisch GRAT II, Daniel Tisch GRAT II
         and James Tisch GRAT II, the "GRATs").

              Thomas J. Tisch, Andrew H. Tisch, Daniel R. Tisch, James S. Tisch,
         4-14P, Andrew Tisch GRAT II, Daniel Tisch GRAT II, James Tisch GRAT II,
         and Thomas Tisch GRAT II are referred to herein individually as a
         "Reporting Person" and collectively as the "Reporting Persons."

              The members of 4-14P are trusts for the benefit of the offspring
         of the Messrs. Tisch, partnerships the partners of which are such
         trusts and partnerships the partners of which are such partnerships.
         The Messrs. Tisch serve as the trustees of such trusts. Thomas J. Tisch
         has been appointed the Manager of 4-14P.

              Each of the GRATs is a grantor retained annuity Trust in which the
         grantor holds an annuity interest and in which the remainder interest
         was created in favor of a trust or trusts for the grantor's offspring.
         Thomas J. Tisch is the grantor and Andrew H. Tisch is the trustee of
         Thomas Tisch GRAT II. Daniel R. Tisch is the grantor and James S. Tisch
         is the trustee of Daniel Tisch GRAT II. James S. Tisch is the grantor
         and Thomas J. Tisch is the trustee of James Tisch GRAT II. Andrew H.
         Tisch is the grantor and Daniel R. Tisch is the trustee of Andrew Tisch
         GRAT II.

              On March 5, 1999, the following transfers occurred (the "GRAT
         Transfers"):

                        1. Four Partners, a New York general partnership ("FP"),
         distributed all of the 1,638,500 shares of Common Stock it owned in
         equal shares of 409,625 each to the four trusts that are partners of
         FP;

                        2. Each of the four trusts that are partners of FP
         distributed all of the 409,625 shares of Common Stock that it had
         received from FP to the Mr. Tisch who is the beneficiary of such trust;

                        3. Each of the Messrs. Tisch contributed all of the
         409,625 shares of Common Stock that he had received to the GRAT for
         which he is the grantor.

              As a result of the GRAT Transfers, FP is no longer the beneficial
         owner of any shares of Common Stock. Beneficial ownership of the shares
         of Common Stock previously held by FP is herein reported by the Messrs.
         Tisch and the GRATs.




                                       4

<PAGE>


              None of the GRAT Transfers was a "sale" for purposes of the
         Securities Act of 1933, as amended (the "Securities Act"), or the
         Securities Exchange Act of 1934, as amended (the "Exchange Act"), and
         collectively represented only a change in the form of beneficial
         ownership of the shares of Common Stock and not an actual change in the
         beneficial ownership of such shares of Common Stock.

              The filing of this statement is not an admission by any Reporting
         Person that such Reporting Person and any other person or persons
         constitute a "group" for purposes of Section 13(d)(3) of the Securities
         Exchange Act of 1934, as amended, or Rule 13d-5 thereunder or that any
         Reporting Person is the beneficial owner of any securities owned by any
         other person.



              [Signatures follow all attachments]




                                       5

<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                    Date of Event Requiring Statement: 3/5/99


              This Form 3 is being filed jointly by the following individuals
         and entities:

              1. Thomas J. Tisch;

              2. Daniel R. Tisch;

              3. James S. Tisch;

              4. Andrew H. Tisch (Thomas J. Tisch, Daniel R. Tisch, James S.
         Tisch and Andrew H. Tisch are referred to collectively as the "Messrs.
         Tisch");

              5. Four-Fourteen Partners, LLC, a Delaware limited liability
         company ("4-14P");

              6. The Thomas J. Tisch 1999 Annuity Trust II ("Thomas Tisch GRAT
         II");

              7. The Daniel R. Tisch 1999 Annuity Trust II ("Daniel Tisch GRAT
         II");

              8. The James S. Tisch 1999 Annuity Trust II ("James Tisch GRAT
         II"); and

              9. The Andrew H. Tisch 1999 Annuity Trust II ("Andrew Tisch GRAT
         II"; and collectively with Thomas Tisch GRAT II, Daniel Tisch GRAT II
         and James Tisch GRAT II, the "GRATs").

              Thomas J. Tisch, Andrew H. Tisch, Daniel R. Tisch, James S. Tisch,
4-14P, Andrew Tisch GRAT II, Daniel Tisch GRAT II, James Tisch GRAT II, and
Thomas Tisch GRAT II are referred to herein individually as a "Reporting Person"
and collectively as the "Reporting Persons." Thomas J. Tisch is the designated
filer for the Reporting Persons.


Joint Filer Information

1.   Name and Address of Reporting Person:

                    Daniel R. Tisch
                    c/o Mentor Partners, LP
                    499 Park Avenue
                    New York, NY  10022




                                       6

<PAGE>


2.   Date of Event Requiring Statement (Month/Day/Year)

                  3/5/99

3.   I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4.   Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5.   Relationship of Reporting Persons(s) to Issuer:

                  ___  Director
                  ___  Officer (give title below)
                  _X_  10% Owner
                  ___  Other (specify below)


6.   If Amendment, Date of Original (Month/Day/Year)



7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ___ Form filed by One Reporting Person
                   _X_ Form filed by More than One Reporting Person


             Table I - Non-Derivative Securities Beneficially Owned


1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  409,625

3.   Ownership Form:  Direct (D) or Indirect (I)

                  I




                                       7

<PAGE>


4.   Nature of Indirect Beneficial Ownership

                 (See explanation to Form 3 of Thomas J. Tisch)


               Table II - Derivative Securities Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)


1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title



         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       8

<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                    Date of Event Requiring Statement: 3/5/99


              This Form 3 is being filed jointly by the following individuals
         and entities:

              1. Thomas J. Tisch;

              2. Daniel R. Tisch;

              3. James S. Tisch;

              4. Andrew H. Tisch (Thomas J. Tisch, Daniel R. Tisch, James S.
         Tisch and Andrew H. Tisch are referred to collectively as the "Messrs.
         Tisch");

              5. Four-Fourteen Partners, LLC, a Delaware limited liability
         company ("4-14P");

              6. The Thomas J. Tisch 1999 Annuity Trust II ("Thomas Tisch GRAT
         II");

              7. The Daniel R. Tisch 1999 Annuity Trust II ("Daniel Tisch GRAT
         II");

              8. The James S. Tisch 1999 Annuity Trust II ("James Tisch GRAT
         II"); and

              9. The Andrew H. Tisch 1999 Annuity Trust II ("Andrew Tisch GRAT
         II"; and collectively with Thomas Tisch GRAT II, Daniel Tisch GRAT II
         and James Tisch GRAT II, the "GRATs").

              Thomas J. Tisch, Andrew H. Tisch, Daniel R. Tisch, James S. Tisch,
4-14P, Andrew Tisch GRAT II, Daniel Tisch GRAT II, James Tisch GRAT II, and
Thomas Tisch GRAT II are referred to herein individually as a "Reporting Person"
and collectively as the "Reporting Persons." Thomas J. Tisch is the designated
filer for the Reporting Persons.


Joint Filer Information

1.   Name and Address of Reporting Person:

                    James S. Tisch
                    667 Madison Avenue
                    New York, NY  10021




                                       9

<PAGE>


2.   Date of Event Requiring Statement (Month/Day/Year)

                  3/5/99

3.   I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4.   Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5.   Relationship of Reporting Persons(s) to Issuer:

                  ___  Director
                  ___  Officer (give title below)
                  _X_  10% Owner
                  ___  Other (specify below)


6.   If Amendment, Date of Original (Month/Day/Year)



7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ___ Form filed by One Reporting Person
                   _X_ Form filed by More than One Reporting Person


             Table I - Non-Derivative Securities Beneficially Owned


1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  409,625

3.   Ownership Form:  Direct (D) or Indirect (I)

                  I




                                       10

<PAGE>


4.   Nature of Indirect Beneficial Ownership

     (See explanation to Form 3 of Thomas J. Tisch)


              Table II - Derivative Securities Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)


1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title



         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       11

<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                    Date of Event Requiring Statement: 3/5/99


              This Form 3 is being filed jointly by the following individuals
         and entities:

              1. Thomas J. Tisch;

              2. Daniel R. Tisch;

              3. James S. Tisch;

              4. Andrew H. Tisch (Thomas J. Tisch, Daniel R. Tisch, James S.
         Tisch and Andrew H. Tisch are referred to collectively as the "Messrs.
         Tisch");

              5. Four-Fourteen Partners, LLC, a Delaware limited liability
         company ("4-14P");

              6. The Thomas J. Tisch 1999 Annuity Trust II ("Thomas Tisch GRAT
         II");

              7. The Daniel R. Tisch 1999 Annuity Trust II ("Daniel Tisch GRAT
         II");

              8. The James S. Tisch 1999 Annuity Trust II ("James Tisch GRAT
         II"); and

              9. The Andrew H. Tisch 1999 Annuity Trust II ("Andrew Tisch GRAT
         II"; and collectively with Thomas Tisch GRAT II, Daniel Tisch GRAT II
         and James Tisch GRAT II, the "GRATs").

              Thomas J. Tisch, Andrew H. Tisch, Daniel R. Tisch, James S. Tisch,
4-14P, Andrew Tisch GRAT II, Daniel Tisch GRAT II, James Tisch GRAT II, and
Thomas Tisch GRAT II are referred to herein individually as a "Reporting Person"
and collectively as the "Reporting Persons." Thomas J. Tisch is the designated
filer for the Reporting Persons.


Joint Filer Information

1.   Name and Address of Reporting Person:

                    Andrew H. Tisch
                    667 Madison Avenue
                    New York, NY  10021




                                       12

<PAGE>


2.   Date of Event Requiring Statement (Month/Day/Year)

                  3/5/99

3.   I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4.   Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5.   Relationship of Reporting Persons(s) to Issuer:

                  ___  Director
                  ___  Officer (give title below)
                  _X_  10% Owner
                  ___  Other (specify below)


6.   If Amendment, Date of Original (Month/Day/Year)



7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ___ Form filed by One Reporting Person
                   _X_ Form filed by More than One Reporting Person
                      


             Table I - Non-Derivative Securities Beneficially Owned


1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  409,625

3.   Ownership Form:  Direct (D) or Indirect (I)

                  I




                                       13

<PAGE>


4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)


              Table II - Derivative Securities Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)


1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title



         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       14

<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                    Date of Event Requiring Statement: 3/5/99


              This Form 3 is being filed jointly by the following individuals
         and entities:

              1. Thomas J. Tisch;

              2. Daniel R. Tisch;

              3. James S. Tisch;

              4. Andrew H. Tisch (Thomas J. Tisch, Daniel R. Tisch, James S.
         Tisch and Andrew H. Tisch are referred to collectively as the "Messrs.
         Tisch");

              5. Four-Fourteen Partners, LLC, a Delaware limited liability
         company ("4-14P");

              6. The Thomas J. Tisch 1999 Annuity Trust II ("Thomas Tisch GRAT
         II");

              7. The Daniel R. Tisch 1999 Annuity Trust II ("Daniel Tisch GRAT
         II");

              8. The James S. Tisch 1999 Annuity Trust II ("James Tisch GRAT
         II"); and

              9. The Andrew H. Tisch 1999 Annuity Trust II ("Andrew Tisch GRAT
         II"; and collectively with Thomas Tisch GRAT II, Daniel Tisch GRAT II
         and James Tisch GRAT II, the "GRATs").

              Thomas J. Tisch, Andrew H. Tisch, Daniel R. Tisch, James S. Tisch,
4-14P, Andrew Tisch GRAT II, Daniel Tisch GRAT II, James Tisch GRAT II, and
Thomas Tisch GRAT II are referred to herein individually as a "Reporting Person"
and collectively as the "Reporting Persons." Thomas J. Tisch is the designated
filer for the Reporting Persons.


Joint Filer Information

1.   Name and Address of Reporting Person:

                    Four-Fourteen Partners LLC
                    c/o Thomas J. Tisch
                    667 Madison Avenue
                    New York, NY  10021




                                       15

<PAGE>


2.   Date of Event Requiring Statement (Month/Day/Year)

                  3/5/99

3.   I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4.   Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5.   Relationship of Reporting Persons(s) to Issuer:

                  ___  Director
                  ___  Officer (give title below)
                  _X_  10% Owner
                  ___  Other (specify below)


6.   If Amendment, Date of Original (Month/Day/Year)



7.   Individual or Joint/Group Filing (Check Applicable Line)

                  ___  Form filed by One Reporting Person
                  _X_  Form filed by More than One Reporting Person


             Table I - Non-Derivative Securities Beneficially Owned


1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  300,000

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D




                                       16

<PAGE>


4.   Nature of Indirect Beneficial Ownership


              Table II - Derivative Securities Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)


1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title



         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       17
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                    Date of Event Requiring Statement: 3/5/99


              This Form 3 is being filed jointly by the following individuals
         and entities:

              1. Thomas J. Tisch;

              2. Daniel R. Tisch;

              3. James S. Tisch;

              4. Andrew H. Tisch (Thomas J. Tisch, Daniel R. Tisch, James S.
         Tisch and Andrew H. Tisch are referred to collectively as the "Messrs.
         Tisch");

              5. Four-Fourteen Partners, LLC, a Delaware limited liability
         company ("4-14P");

              6. The Thomas J. Tisch 1999 Annuity Trust II ("Thomas Tisch GRAT
         II");

              7. The Daniel R. Tisch 1999 Annuity Trust II ("Daniel Tisch GRAT
         II");

              8. The James S. Tisch 1999 Annuity Trust II ("James Tisch GRAT
         II"); and

              9. The Andrew H. Tisch 1999 Annuity Trust II ("Andrew Tisch GRAT
         II"; and collectively with Thomas Tisch GRAT II, Daniel Tisch GRAT II
         and James Tisch GRAT II, the "GRATs").

              Thomas J. Tisch, Andrew H. Tisch, Daniel R. Tisch, James S. Tisch,
4-14P, Andrew Tisch GRAT II, Daniel Tisch GRAT II, James Tisch GRAT II, and
Thomas Tisch GRAT II are referred to herein individually as a "Reporting Person"
and collectively as the "Reporting Persons." Thomas J. Tisch is the designated
filer for the Reporting Persons.


Joint Filer Information

1.   Name and Address of Reporting Person:

                    The Thomas J. Tisch 1999 Annuity Trust II
                    c/o Mr. Barry Bloom
                    665 Madison Avenue
                    New York, NY  10021




                                       18

<PAGE>


2.   Date of Event Requiring Statement (Month/Day/Year)

                  3/5/99

3.   I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4.   Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5.   Relationship of Reporting Persons(s) to Issuer:

                  ___  Director
                  ___  Officer (give title below)
                  _X_  10% Owner
                  ___  Other (specify below)


6.   If Amendment, Date of Original (Month/Day/Year)



7.   Individual or Joint/Group Filing (Check Applicable Line)

                  ___  Form filed by One Reporting Person
                  _X_  Form filed by More than One Reporting Person


             Table I - Non-Derivative Securities Beneficially Owned


1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  409,625

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D




                                       19

<PAGE>

4.   Nature of Indirect Beneficial Ownership


              Table II - Derivative Securities Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)


1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title



         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       20

<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                    Date of Event Requiring Statement: 3/5/99


              This Form 3 is being filed jointly by the following individuals
         and entities:

              1. Thomas J. Tisch;

              2. Daniel R. Tisch;

              3. James S. Tisch;

              4. Andrew H. Tisch (Thomas J. Tisch, Daniel R. Tisch, James S.
         Tisch and Andrew H. Tisch are referred to collectively as the "Messrs.
         Tisch");

              5. Four-Fourteen Partners, LLC, a Delaware limited liability
         company ("4-14P");

              6. The Thomas J. Tisch 1999 Annuity Trust II ("Thomas Tisch GRAT
         II");

              7. The Daniel R. Tisch 1999 Annuity Trust II ("Daniel Tisch GRAT
         II");

              8. The James S. Tisch 1999 Annuity Trust II ("James Tisch GRAT
         II"); and

              9. The Andrew H. Tisch 1999 Annuity Trust II ("Andrew Tisch GRAT
         II"; and collectively with Thomas Tisch GRAT II, Daniel Tisch GRAT II
         and James Tisch GRAT II, the "GRATs").

              Thomas J. Tisch, Andrew H. Tisch, Daniel R. Tisch, James S. Tisch,
4-14P, Andrew Tisch GRAT II, Daniel Tisch GRAT II, James Tisch GRAT II, and
Thomas Tisch GRAT II are referred to herein individually as a "Reporting Person"
and collectively as the "Reporting Persons." Thomas J. Tisch is the designated
filer for the Reporting Persons.


Joint Filer Information

1.   Name and Address of Reporting Person:

                    The Daniel R. Tisch 1999 Annuity Trust II
                    c/o Mr. Barry Bloom
                    665 Madison Avenue
                    New York, NY  10021




                                       21

<PAGE>


2.   Date of Event Requiring Statement (Month/Day/Year)

                  3/5/99

3.   I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4.   Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5.   Relationship of Reporting Persons(s) to Issuer:

                  ___  Director
                  ___  Officer (give title below)
                  _X_  10% Owner
                  ___  Other (specify below)


6.   If Amendment, Date of Original (Month/Day/Year)



7.   Individual or Joint/Group Filing (Check Applicable Line)

                  ___  Form filed by One Reporting Person
                  _X_  Form filed by More than One Reporting Person


             Table I - Non-Derivative Securities Beneficially Owned


1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  409,625

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D




                                       22

<PAGE>


4.   Nature of Indirect Beneficial Ownership


              Table II - Derivative Securities Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)


1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title



         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       23

<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                    Date of Event Requiring Statement: 3/5/99


              This Form 3 is being filed jointly by the following individuals
         and entities:

              1. Thomas J. Tisch;

              2. Daniel R. Tisch;

              3. James S. Tisch;

              4. Andrew H. Tisch (Thomas J. Tisch, Daniel R. Tisch, James S.
         Tisch and Andrew H. Tisch are referred to collectively as the "Messrs.
         Tisch");

              5. Four-Fourteen Partners, LLC, a Delaware limited liability
         company ("4-14P");

              6. The Thomas J. Tisch 1999 Annuity Trust II ("Thomas Tisch GRAT
         II");

              7. The Daniel R. Tisch 1999 Annuity Trust II ("Daniel Tisch GRAT
         II");

              8. The James S. Tisch 1999 Annuity Trust II ("James Tisch GRAT
         II"); and

              9. The Andrew H. Tisch 1999 Annuity Trust II ("Andrew Tisch GRAT
         II"; and collectively with Thomas Tisch GRAT II, Daniel Tisch GRAT II
         and James Tisch GRAT II, the "GRATs").

              Thomas J. Tisch, Andrew H. Tisch, Daniel R. Tisch, James S. Tisch,
4-14P, Andrew Tisch GRAT II, Daniel Tisch GRAT II, James Tisch GRAT II, and
Thomas Tisch GRAT II are referred to herein individually as a "Reporting Person"
and collectively as the "Reporting Persons."


Joint Filer Information

1.   Name and Address of Reporting Person:

                    The James S. Tisch 1999 Annuity Trust II
                    c/o Thomas J. Tisch
                    665 Madison Avenue
                    New York, NY  10021




                                       24

<PAGE>


2.   Date of Event Requiring Statement (Month/Day/Year)

                  3/5/99

3.   I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4.   Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5.   Relationship of Reporting Persons(s) to Issuer:

                  ___  Director
                  ___  Officer (give title below)
                  _X_  10% Owner
                  ___  Other (specify below)


6.   If Amendment, Date of Original (Month/Day/Year)



7.   Individual or Joint/Group Filing (Check Applicable Line)

                  ___  Form filed by One Reporting Person
                  _X_  Form filed by More than One Reporting Person


             Table I - Non-Derivative Securities Beneficially Owned


1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  409,625

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D




                                       25

<PAGE>


4.   Nature of Indirect Beneficial Ownership


              Table II - Derivative Securities Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)


1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title



         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       26

<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                    Date of Event Requiring Statement: 3/5/99


              This Form 3 is being filed jointly by the following individuals
         and entities:

              1. Thomas J. Tisch;

              2. Daniel R. Tisch;

              3. James S. Tisch;

              4. Andrew H. Tisch (Thomas J. Tisch, Daniel R. Tisch, James S.
         Tisch and Andrew H. Tisch are referred to collectively as the "Messrs.
         Tisch");

              5. Four-Fourteen Partners, LLC, a Delaware limited liability
         company ("4-14P");

              6. The Thomas J. Tisch 1999 Annuity Trust II ("Thomas Tisch GRAT
         II");

              7. The Daniel R. Tisch 1999 Annuity Trust II ("Daniel Tisch GRAT
         II");

              8. The James S. Tisch 1999 Annuity Trust II ("James Tisch GRAT
         II"); and

              9. The Andrew H. Tisch 1999 Annuity Trust II ("Andrew Tisch GRAT
         II"; and collectively with Thomas Tisch GRAT II, Daniel Tisch GRAT II
         and James Tisch GRAT II, the "GRATs").

              Thomas J. Tisch, Andrew H. Tisch, Daniel R. Tisch, James S. Tisch,
4-14P, Andrew Tisch GRAT II, Daniel Tisch GRAT II, James Tisch GRAT II, and
Thomas Tisch GRAT II are referred to herein individually as a "Reporting Person"
and collectively as the "Reporting Persons."


Joint Filer Information

1.   Name and Address of Reporting Person:

                    The Andrew H. Tisch 1999 Annuity Trust II
                    c/o Mr. Barry Bloom
                    665 Madison Avenue
                    New York, NY  10021




                                       27

<PAGE>

2.   Date of Event Requiring Statement (Month/Day/Year)

                  3/5/99

3.   I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4.   Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5.   Relationship of Reporting Persons(s) to Issuer:

                  ___  Director
                  ___  Officer (give title below)
                  _X_  10% Owner
                  ___  Other (specify below)


6.   If Amendment, Date of Original (Month/Day/Year)



7.   Individual or Joint/Group Filing (Check Applicable Line)

                  ___  Form filed by One Reporting Person
                  _X_  Form filed by More than One Reporting Person


             Table I - Non-Derivative Securities Beneficially Owned


1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  409,625

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D




                                       28

<PAGE>


4.   Nature of Indirect Beneficial Ownership


              Table II - Derivative Securities Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)


1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title



         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       29

<PAGE>


                                    SIGNATURE


                  WITNESS, the signatures of the undersigned this 15th day of
March 1999.

                                     FOUR-FOURTEEN PARTNERS, LLC

                                     By /s/ Thomas J. Tisch
                                       ------------------------------------
                                       Thomas J. Tisch, Manager


                                        /s/ Andrew H. Tisch
                                     --------------------------------------
                                            Andrew H. Tisch


                                        /s/ Daniel R. Tisch
                                     --------------------------------------
                                            Daniel R. Tisch


                                        /s/ James S. Tisch
                                     --------------------------------------
                                            James S. Tisch


                                        /s/ Thomas J. Tisch
                                     --------------------------------------
                                            Thomas J. Tisch

                                     THE ANDREW H. TISCH 1999 ANNUITY TRUST II

                                     By   /s/ Daniel R. Tisch
                                       ------------------------------------
                                          Daniel R. Tisch, Trustee

                                     THE DANIEL R. TISCH 1999 ANNUITY TRUST II

                                     By   /s/ James S. Tisch
                                       ------------------------------------
                                          James S. Tisch, Trustee




                                       30

<PAGE>

                                     THE JAMES S. TISCH 1999 ANNUITY TRUST II

                                     By   /s/ Thomas J. Tisch
                                       ------------------------------------
                                          Thomas J. Tisch, Trustee

                                     THE THOMAS J. TISCH 1999 ANNUITY TRUST II

                                     By   /s/ Andrew H. Tisch
                                       ------------------------------------
                                          Andrew H. Tisch, Trustee





                                       31


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