NEUROGEN CORP
11-K, 1999-07-15
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549



                                    FORM 11-K



               [X] ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE
                        SECURITIES EXCHANGE ACT OF 1934


                                       OR


             [ ] TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE
                        SECURITIES EXCHANGE ACT OF 1934
                        For the transition period from to




                         Commission file number 0-18311




                  NEUROGEN CORPORATION 401 (k) RETIREMENT PLAN
                               Full title of plan



                              NEUROGEN CORPORATION


                          35 Northeast Industrial Road
                           Branford, Connecticut 06405
                                 (203) 488-8201
          (Name of issuer of the securities held pursuant to the plan)
<PAGE>
                              Neurogen Corporation
                            401 (k) Retirement Plan

                              FINANCIAL STATEMENTS

                                     INDEX

                                                                      Page
                                                                      ----

    Report of Independent Accountants                                   1

    Financial Statements:

     Statements of Net Assets Available for Benefits as of
       December 31, 1998 and 1997                                       2

     Statement of Changes in Net Assets Available for Benefits
       for the year ended December 31, 1998                            3-4

     Notes to Financial Statements                                     5-8

     Supplemental Schedules:

          Item 27a - Schedule of Assets Held for Investment
                     Purposes as of December 31, 1998                    9

          Item 27d - Schedule of Reportable Transactions for
                     the Year Ended December 31, 1998                    10






<PAGE>
                       Report of Independent Accountants

To the Participants and Administrator of the
Neurogen Corporation 401 (k) Retirement Plan

In our opinion, the accompanying statements of net assets available for benefits
and the  related  statement  of  changes in net assets  available  for  benefits
present fairly, in all material respects,  the net assets available for benefits
of the Neurogen Corporation 401 (k) Retirement Plan (the "Plan") at December 31,
1998 and December 31, 1997, and the changes in net assets available for benefits
for the year ended  December  31, 1998 in  conformity  with  generally  accepted
accounting principles.  These financial statements are the responsibility of the
Plan's  management;  our  responsibility  is to  express  an  opinion  on  these
financial  statements  based on our  audits.  We  conducted  our audits of these
statements  in accordance  with  generally  accepted  auditing  standards  which
require that we plan and perform the audit to obtain reasonable  assurance about
whether the financial  statements  are free of material  misstatement.  An audit
includes  examining,  on a test  basis,  evidence  supporting  the  amounts  and
disclosures in the financial  statements,  assessing the  accounting  principles
used and  significant  estimates made by management,  and evaluating the overall
financial  statement  presentation.   We  believe  that  our  audits  provide  a
reasonable basis for the opinion expressed above.

Our audits  were  conducted  for the  purpose of forming an opinion on the basic
financial statements taken as a whole. The supplemental  Schedule of Assets Held
for  Investment  Purposes as of December  31,  1998 and  Schedule of  Reportable
Transactions  for the Year Ended December 31, 1998 are presented for the purpose
of  additional  analysis  and are not a  required  part of the  basic  financial
statements  but are  supplementary  information  required by the  Department  of
Labor's Rules and  Regulations  for Reporting and Disclosure  under the Employee
Retirement  Income Security Act of 1974.  These  supplemental  schedules are the
responsibility  of the Plan's  management.  The supplemental  schedules and fund
information have been subjected to the auditing procedures applied in the audits
of the basic financial  statements and, in our opinion, are fairly stated in all
material  respects  in  relation to the basic  financial  statements  taken as a
whole.

The  schedule  of  Assets  Held for  Investment  Purposes  and the  Schedule  of
Reportable  Transactions  that accompany the Plan's financial  statements do not
disclose  the  historical  cost  of  certain  plan  assets  held  by the  Plan's
custodians.  Disclosure  of this  information  is required by the  Department of
Labor's Rules and  Regulations  for Reporting and Disclosure  under the Employee
Retirement Income Security Act of 1974.

PricewaterhouseCoopers LLP
July 9, 1999









<PAGE>



                              Neurogen Corporation
                             401(k) Retirement Plan
                Statements of Net Assets Available for Benefits

<TABLE>
<CAPTION>

<S>                                                                 <C>             <C>
                                                                       December 31,
                                                                   1998             1997

                                                                   ----             ----
ASSETS:

Employer contribution receivable                                $ 47,103
Employee contribution receivable                                  18,954              -

Investments at fair market value:
    Neurogen Corporation common stock                            614,327          214,070
    Loans to participants                                         76,379           44,608
    Charles Schwab Money Market Funds                              7,586            4,198

    Investment in Pooled Separate Accounts of
    Manufacturer's Life Insurance Company:
          Money Market Fund                                      260,058          142,815
          Short-Term Government Fund                              63,776           73,946
          Income Fund                                             53,391           47,517
          High Yield Fund                                        181,785          154,804
          Diversified Capital Fund                                51,707           31,566
          Growth & Income Fund                                   767,683          629,176
          Contra Fund                                          1,049,217          585,492
          Growth Opportunities Fund                            1,215,470          886,895
          Foreign Fund                                           190,432          152,002
          International Stock Fund                                85,930           57,674
                                                               ---------        ---------
                                                               3,919,449        2,761,887
                                                               ---------        ---------
          Total investments                                    4,617,741        3,024,763
                                                               ---------        ---------
                 Net assets available for benefits           $ 4,683,798      $ 3,024,763
                                                               =========        =========


The accompanying notes are an integral part of the financial statements.

</TABLE>

<PAGE>


                   Neurogen Corporation 401(k) Retirement Plan
                 Statement of Changes in Net Assets Available for Benefits

<TABLE>
<CAPTION>


<S>                                 <C>               <C>             <C>



                                                                 Plan year ended December 31, 1998
                                                                        Participant Directed
                                   -------------------------------------------------------------------------------------------------
                                      Money        Short-                High    Diversified     Growth                   Growth
                                      Market     Term Gov't   Income    Yield      Capital      & Income    Contra    Opportunities
                                      Fund          Fund       Fund      Fund        Fund          Fund      Fund          Fund
                                   -----------  -----------  --------  --------- -------------  ----------  ----------  ------------
Additions to net assets available
 for benefits:

Contributions received or
  receivable from:
    Employer                       $     6,041    $     980  $  4,081   $10,000      $ 4,535    $ 19,958    $ 45,374    $   26,911
    Employees                           40,602        4,526    16,789    55,939       21,037      96,781     233,144       145,496
                                    ----------  -----------  --------  --------  -------------  ----------  ----------  ------------
    Total contributions                 46,643        5,506    20,870    65,939       25,572     116,739     278,518       172,407


Net appreciation (depreciation) in
  fair value of investments              7,086        4,449     3,182    (4,931)        (675)     65,103     230,200       229,548
Other income-interest repayments             -            -         -         -            -           -           -             -
Participant loan repayments                 63            -       378       875            -       6,242       7,192         6,511
                                   -----------  -----------  --------  --------  -------------  ----------  ----------  ------------
    Total income                        53,792        9,955    24,430    61,883       24,897     188,084     515,910       408,466

Deductions from net assets available
 for benefits:

Distribution of benefits and payments
 to provide benefits:
   Directly to participants and
     their beneficiaries               (87,120)     (14,432)    (9,796)   (1,295)           -      (26,988)    (17,118)     (30,992)
Participant loans                            -            -     (3,152)   (6,299)           -      (10,403)    (16,684)     (12,682)
Administrative expenses                   (559)        (220)      (178)     (649)         (152)     (2,367)     (2,795)      (3,491)
                                   -----------  -----------  ---------  -------- -------------  ----------  ----------  ------------
   Total deductions                    (87,679)     (14,652)   (13,126)   (8,243)         (152)    (39,758)    (36,597)     (47,165)
                                   -----------  -----------  ---------  -------- -------------  ----------  ----------  ------------
      Net increase (decrease)          (33,887)      (4,697)    11,304    53,640        24,745     148,326     479,313       361,301

Interfund transfers (net)              152,137       (5,345)    (4,696)  (23,754)       (3,712)     (4,349)     (3,958)     (25,624)

Net assets available for
 benefits:

Beginning of year                      142,816       73,946     47,517   154,804        31,566     629,176     585,492       886,895
                                   -----------  -----------  ---------  -------- -------------  ----------  ----------  ------------

End of year                        $   261,066  $    63,904  $ 54,125   $184,690 $      52,599  $  773,153  $1,060,847  $  1,222,572
                                   ===========  ===========  =========  ======== =============  ==========  ==========  ============

- ---table continued below

The accompanying notes are an integral part of the financial statements.

</TABLE>
<PAGE>
                  Neurogen Corporation 401(k) Retirement Plan
           Statement of Changes in Net Assets Available for Benefits
<TABLE>
<CAPTION>

<S>                                  <C>           <C>         <C>           <C>           <C>            <C>        <C>
                                                               Plan year ended December 31, 1998
                                             Participant Directed                    Non-Participant Directed
                                   ---------------------------------------  ----------------------------------------
                                                   Int'l       Neurogen      Neurogen      Participant
                                     Foreign       Stock        Stock -       Stock -         Notes
                                       Fund        Fund       Unrestricted  Restricted     Receivables       Total
                                   -----------  -----------  -------------  -----------    -------------  ----------
Additions to net assets available
 for benefits:

Contributions received or
  receivable from:
    Employer                       $     12,948  $     7,737   $    12,406  $    302,390   $          -    $ 453,361
    Employees                            76,923       46,246        38,635            -               -      776,118
                                    -----------  -----------  ------------  ------------   -------------   ----------
    Total contributions                  89,871       53,983        51,041       302,390              -    1,229,479


Net appreciation (depreciation) in
 fair value of investments               (9,858)      11,411        70,576        32,353               -     638,444
Other income-interest repayments              -            -            -              -           5,499       5,499
Participant loan repayments               2,999          759           868             -         (25,887)          -
                                    -----------  -----------  ------------  ------------   -------------  ----------

    Total income                         83,012       66,153       122,485       334,743         (20,388)  1,873,422

Deductions from net assets available
 for benefits:

Distribution of benefits and payments
 to provide benefits:
   Directly to participants and
     their beneficiaries                  (9,443)      (1,487)            -             -          (1,637)   (200,308)
Participant loans                         (4,283)        (293)            -             -          53,796           -
Administrative expenses                     (568)        (237)       (2,863)            -               -     (14,079)
                                     -----------  -----------  ------------  ------------   -------------  ----------
   Total deductions                      (14,294)      (2,017)       (2,863)            -          52,159    (214,387)
                                     -----------  -----------  ------------  ------------   -------------  ----------
      Net increase (decrease)             68,718       64,136       119,622       334,743          31,771   1,659,035

Interfund transfers, net                 (27,857)     (34,543)      (14,889)       (3,410)              -           -

Net assets available for
 benefits:

Beginning of year                        152,002       57,674       218,267             -          44,608   3,024,763
                                     -----------  -----------  ------------  ------------   -------------  ----------

End of year                         $    192,863  $    87,267  $    323,000  $    331,333   $      76,379  $4,683,798
                                     ===========  ===========  ============  ============   =============  ==========




The accompanying notes are an integral part of the financial statements.

</TABLE>

<PAGE>


                              Neurogen Corporation
                             401(k) Retirement Plan

                         NOTES TO FINANCIAL STATEMENTS

1. Description of the Plan:

General
- -------
The  Neurogen  Corporation  401(k)  Retirement  Plan (the  "Plan")  is a defined
contribution plan. All regularly  employed  full-time  employees employed by the
Company on the first day of a calendar  quarter  following the date on which the
employee first completed an hour of service are eligible to  participate.  It is
subject to the provisions of the Employee Retirement Income Security Act of 1974
("ERISA") and is intended to meet the  requirements of Section  401(a),  401(k),
and 501(a) of the Internal Revenue Code of 1986, as amended (the "Code").

The Company as the  administrator  of the Plan is  responsible  for  determining
employer contributions,  determining limits if any, on loan requests,  reviewing
financial  hardship  requests for  participant  withdrawals and to set rules and
administrative  policy as it may deem  necessary to carry out the  provisions of
the Plan.

Contributions
- -------------
Employees  may  elect to  contribute  up to 15% of  their  earnings  or  $10,000
whichever  is less.  Contribution  rates  may be  changed  on the first day of a
calendar quarter.

The Plan provides that the Company will match the employee's  contribution in an
amount  equal  to  100%  of  the  participant's  contribution  up to  6% of  the
participant's gross pay. The matching  contribution is made up of two parts. One
third  of  the  contribution  is in  cash  that  may be  invested  in any of the
investment funds offered.  The other two-thirds is in Neurogen stock and may not
be transferred to another investment fund.

Participant accounts
- --------------------
Each participant's  account is credited with the participant's  contribution and
allocations  of the  Company's  matching  contribution,  and  plan  earnings  as
described in the Plan  document.  The benefit to which a participant is entitled
is the benefit that can be provided from the participant's vested account.

Vesting
- -------
Participants vest on employer  matching  contributions at a rate of 25% for each
whole year of service and are 100% vested after four years of credited service.

Investment Options
- ------------------

Upon enrollment in the Plan, a participant may direct employee  contributions in
1 percent  increments  to purchase  Neurogen  common stock and to the  following
Manufacturer's Life Insurance Company  ("Manulife") pooled separate account fund
choices:

Aggressive Growth Funds
- -----------------------
Manulife  International  Stock  Fund - This fund  invests  in the T. Rowe  Price
International Stock Fund. The fund invests primarily in common stocks of foreign
companies that have the potential for growth of capital or income or both.

Manulife  Foreign Fund - This fund invests in the Templeton  Foreign Fund.  This
fund invests using a traditional value strategy.  It invests in stocks primarily
outside the United States drawn from a list of the world's "cheapest"  companies
relative to assets and long-term earnings.

Growth Funds
- ------------
Manulife  Contra Fund - Invests in the Fidelity  Contra Fund.  This fund invests
primarily in undervalued  common stocks and convertible  securities in companies
that are currently  out of favor with the  investing  public but that may have a
favorable long-term outlook.

Manulife  Growth  Opportunities  Fund  -  Invests  in  Fidelity  Advisor  Growth
Opportunities  Fund. This fund invests primarily in common stocks and securities
convertible into common stocks of companies with long-term growth potential.

Growth and Income Funds
- -----------------------
Manulife  Growth & Income  Fund - Invests in the T. Rowe  Price  Growth & Income
Fund.  This fund invests  primarily in common stocks of companies whose earnings
are expected to grow at a rate in excess of that of common stocks in general and
are adequate to support a growing dividend.

Manulife  Diversified  Capital Fund - Invests in SoGen  International Fund. This
fund  invests  in a  diversified  portfolio  of  assets,  including  equity  and
fixed-income  securities  of U.S. and foreign  companies.  Investments  in fixed
income instruments may be for capital appreciation potential as well as income.

Income Funds
- ------------
Manulife High Yield Fund - Invests in Fidelity  Advisor  High-Yield  Fund.  This
fund invests primarily in high-yielding  non-investment grade,  fixed-income and
zero coupon securities, as well as convertible securities and preferred stocks.

Manulife  Income Fund - Invests in T. Rowe Price Spectrum Income Fund. This fund
invests in a diversified group of underlying T. Rowe Price funds,  which in turn
invest principally in fixed income securities.

Manulife  short-term   Government  Fund  -  Invests  in  Vanguard  Fixed  Income
Securities  Fund. This fund's objective is to maintain a high level of safety of
principal and generate  returns  consistent  with an average  maturity of two to
three years.

Conservative Fund
- -----------------
Manulife Money Market Fund. This fund's objective is to maintain a high level of
safety of principal  and generate  returns  higher than those  available on U.S.
Treasury bills alone.

Participants may change their investment options daily.

Loans and Withdrawals
- ---------------------

Participants  may borrow from their fund  accounts a minimum of $1,000,  up to a
maximum equal to the lesser of $50,000,  or 50% of their vested account balance.
Loan  transactions  are treated as a transfer to (from) the investment fund from
(to) the  Participant  Notes  Receivable  fund. Loan terms vary with the maximum
being  ten  years.  The  loans  are   collateralized   by  the  balance  in  the
participant's account and bear interest at a rate 1% over the prime rate.

A participant  may withdraw all or any portion of his vested  account  resulting
from his  contributions,  subject to proof of hardship due to an  immediate  and
significant  financial need as further described in the Plan document.  The plan
administrator in accordance with  nondiscriminatory  standards applied uniformly
to all participants  similarly makes the determination of financial hardship.

Payment of Benefits
- -------------------
On termination of service due to death, disability or retirement,  a participant
may elect to receive a lump-sum  amount equal to the value of the  participant's
vested interest in his or her account.  If a participant  terminates  employment
but  termination  is  not  due to  death,  disability  or  retirement,  and  the
participant is not yet 65, the  participant  may keep his account balance in the
plan if it is higher than $5,000.  If the participant  chooses  distribution the
distribution  will  occur  as soon as  practicable  after  the  participant  has
completed the proper form providing  instruction as to where the funds should be
transferred.

Forfeited Accounts
- ------------------
Any forfeitures will first be applied to pay expenses under the Plan which would
otherwise be paid by the employer. Remaining forfeitures, if any, will be deemed
to reduce the employer  contribution.  At December 31, 1998, forfeited nonvested
accounts totaled $ 7,465.  These accounts will be used to reduce future employer
contributions.  In 1998  administrative fees for the Plan were reduced by $2,879
from forfeited nonvested accounts.

2. Summary of Accounting Policies:

Basis of Accounting
- -------------------
The financial  statements of the Plan are prepared  under the accrual  method of
accounting.

Use of Estimates
- ----------------
The preparation of financial  statements in conformity  with generally  accepted
accounting principles requires management to make estimates and assumptions that
affect the reported amounts of assets,  liabilities,  and changes  therein,  and
disclosure of contingent  assets and  liabilities.  Actual  results could differ
from those estimates.

Investment Valuation and Income Recognition
- -------------------------------------------
The Company  utilizes a third party  record-keeper to prepare the records of the
plan,  to  process  transfers  between  investment   choices,   and  to  process
distributions.

The mutual fund  accounts are pooled  separate  accounts  through an  investment
contract with the Manufacturers Life Insurance Company  ("Manulife").  Shares of
mutual fund accounts are valued at quoted  market prices that  represent the net
asset value of shares held by the Plan at year-end.  The Company stock is valued
at its quoted market price and held in a brokerage  account at Charles  Schwab &
Company.

An administrative  maintenance  charge is applied to each of the pooled Manulife
funds and is outlined in the  contract.  The Plan  presents in the  statement of
changes in net assets available for benefits the net appreciation (depreciation)
in the fair value of its  investments  which  consists of the realized  gains or
losses and the unrealized appreciation (depreciation) on those investments,  and
investment income from the pooled separate accounts.

Participant  notes receivable are valued at cost which  approximates fair value.
Purchases  and  sales are  recorded  at the trade  date and  interest  income is
recorded on the accrual basis.

Plan Expenses
- -------------
Transaction  fees are offset by forfeitures,  with any expenses in excess of the
forfeiture being paid by the Company.  The Company incurred  expenses of $49,338
and  $19,145  for the plan  years  1998 and 1997,  respectively,  which were not
charged to the Plan. The Participant pays loan  administrative  expenses of $100
per loan.

Plan Termination
- ----------------
Although  it has not  expressed  any intent to do so, the  Company has the right
under the Plan to discontinue its contributions at any time and to terminate the
Plan, subject to the provisions of ERISA.

Reconciliation of Financial Statements to Form 5500
- ---------------------------------------------------
Certain items are  classified  differently in the Plan's annual report Form 5500
than they are presented in the  accompanying  statements of Net Assets Available
for Benefits. These represent classification differences only.

Tax Status
- ----------
The Internal Revenue Service has determined and informed the Company by a letter
dated October 22, 1996, that the plan, as then designed,  was in compliance with
the  applicable  requirements  of the Internal  Revenue Code.  The plan has been
amended  since   receiving  the   determination   letter.   However,   the  plan
administrator  and the plan's tax  counsel  believe  that the plan is  currently
designed and being operated in compliance  with the applicable  requirements  of
the Internal Revenue Code.

3.  Investments

Investments in Neurogen Corporation Stock,  Manulife Money Market Fund, Manulife
Growth and Income Fund, Manulife Contra Fund, and Manulife Growth  Opportunities
Fund represent 5 percent or more of the Plan's net assets available for benefits
as of December 31, 1998.
<PAGE>


<TABLE>
<CAPTION>
                   Neurogen Corporation 401(k) Retirement Plan
           Item 27a - Schedule of Assets Held for Investment Purposes
<S>                                         <C>
                                December 31, 1998

(a)       (b) Issuer               (c) Description of Investment      (d) Cost       (e) Current Value
- ---       ----------               -----------------------------      --------       -----------------
 *        Neurogen Corporation     Common stock, par value $.025      $   **         $        614,327

 *        Participants             Participant loans with interest
                                   rates between 8.75% and 9.75%,
                                   collaterized by participant
                                   account balances                     76,379                 76,379

 *        Charles Schwab           Money Market Fund                     7,586                  7,586

 *        Manulife                 Money Market Fund                   260,058                260,058

 *        Manulife                 Short-Term Government Fund             **                   63,776

 *        Manulife                 Income Fund                            **                   53,391

 *        Manulife                 High Yield Fund                        **                  181,785

 *        Manulife                 Diversified Capital Fund               **                   51,707

 *        Manulife                 Growth and Income Fund                 **                  767,683

 *        Manulife                 Growth Opportunities Fund              **                1,215,470

 *        Manulife                 Contra Fund                            **                1,049,217

 *        Manulife                 Foreign Fund                           **                  190,432

 *        Manulife                 International Stock Fund               **                   85,930
                                                                                     -----------------
                                                                                     $      4,617,741
                                                                                     =================



*  Indentified as a party in interest

** Information not available from normal business records



</TABLE>
<PAGE>

<TABLE>
<CAPTION>
                   Neurogen Corporation 401(k) Retirement Plan
                 Item 27d - Schedule of Reportable Transactions
<S>                                        <C>              <C>            <C>
                        Plan Year Ended December 31, 1998

Series of transactions exceeding 5% of current value of Plan Assets as of January 1, 1998

                                                              Aggregate                   Aggregate
                                               Number of      Cost of        Number of    Proceeds      Net Gain
Name of Investment                           Transactions     Purchases    Transactions   from Sales    or (Loss)
- ------------------                           ------------     ---------    ------------   ----------    ---------

Charles Schwab Money Market Fund                  60          $ 246,255         42         $ 242,867    $    -
Neurogen Corporation Stock                        40            396,752          6           101,784         *
Manulife Money Market Fund                        76            285,399         30           174,686         *
Manulife Contra Fund                              76            206,348         30            88,481         *
Manulife Growth Opportunities Fund                63            298,719         27            77,729         *
Manulife High Yield Fund                          64            100,900         11            63,338         *
Manulife Growth and Income Fund                   69            130,612         21            54,843         *



Note:  No lease rentals or expenses incurred with transactions

*  Information not available from normal business records












</TABLE>




<PAGE>

                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
trustees (or other persons who administer the plan) have duly caused this annual
report to be signed on its behalf by the undersigned hereunto duly authorized.

                                                Neurogen Corporation 401(k) Plan


                                            Administrator:  Neurogen Corporation



Date:  July 15, 1999                  By: /s/ STEPHEN R. DAVIS
                                          ---------------------
                                      Stephen R. Davis
                                      Vice President and Chief Financial Officer




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