NEUROGEN CORP
11-K, 2000-06-30
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 11-K

               [X] ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE
                        SECURITIES EXCHANGE ACT OF 1934


                                       OR

             [ ] TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE
                        SECURITIES EXCHANGE ACT OF 1934
                        For the transition period from to

                         Commission file number 0-18311

                   NEUROGEN CORPORATION 401(k) RETIREMENT PLAN
                               Full title of plan

                              NEUROGEN CORPORATION

                          35 Northeast Industrial Road

                           Branford, Connecticut 06405

                                 (203) 488-8201

          (Name of issuer of the securities held pursuant to the plan)
<PAGE>
                   Neurogen Corporation 401(k) Retirement Plan

                              FINANCIAL STATEMENTS

                                      INDEX

                                                                      Page

                                                                      ----

    Report of Independent Accountants                                    1

    Financial Statements:

     Statements of Net Assets Available for Benefits as of
       December 31, 1999 and 1998                                        2

     Statement of Changes in Net Assets Available for Benefits
       for the Year Ended December 31, 1999                              3

     Notes to Financial Statements                                     4-7

     Supplemental Schedules:

          Schedule of Assets Held for Investment Purposes At
          End of Year                                                    8

          Schedule of Reportable Transactions                            9

          Schedule of Nonexempt Transactions                            10






<PAGE>

                        Report of Independent Accountants

To the Participants and Administrator of the
Neurogen Corporation 401(k) Retirement Plan

In our opinion, the accompanying statements of net assets available for benefits
and the  related  statement  of  changes in net assets  available  for  benefits
present fairly, in all material respects,  the net assets available for benefits
of the Neurogen Corporation 401(k) Retirement Plan (the "Plan") at December 31,
1999 and December 31, 1998, and the changes in net assets available for benefits
for the year ended December 31, 1999 in conformity  with  accounting  principles
generally  accepted in the United  States.  These  financial  statements are the
responsibility  of the Plan's  management;  our  responsibility is to express an
opinion on these  financial  statements  based on our audits.  We conducted  our
audits of these  statements in  accordance  with  auditing  standards  generally
accepted in the United  States, which require that we plan and perform the audit
to obtain reasonable  assurance about whether the financial  statements are free
of material misstatement. An audit includes examining, on a test basis, evidence
supporting the amounts and  disclosures in the financial  statements,  assessing
the accounting principles used and significant estimates made by management, and
evaluating the overall  financial  statement  presentation.  We believe that our
audits provide a reasonable basis for the opinion expressed above.

Our audits  were  conducted  for the  purpose of forming an opinion on the basic
financial statements taken as a whole. The supplemental schedules of Assets Held
for Investment  Purposes At End of Year,  Reportable  Transactions and Nonexempt
Transactions are presented for the purpose of additional  analysis and are not a
required  part  of  the  basic  financial   statements  but  are   supplementary
information  required by the  Department  of Labor's Rules and  Regulations  for
Reporting and Disclosure  under the Employee  Retirement  Income Security Act of
1974.  These  supplemental  schedules  are  the  responsibility  of  the  Plan's
management.  The  supplemental  schedules  have been  subjected  to the auditing
procedures  applied in the audits of the basic financial  statements and, in our
opinion,  are fairly  stated in all  material  respects in relation to the basic
financial statements taken as a whole.

The supplemental  schedule of Assets Held for Investment Purposes At End of Year
that  accompanies  the  Plan's  financial   statements  does  not  disclose  the
historical  cost of  non-participant  directed  Plan  assets  held by the Plan's
custodians.  Disclosure  of this  information  is required by the  Department of
Labor's Rules and  Regulations  for Reporting and Disclosure  under the Employee
Retirement Income Security Act of 1974.

PricewaterhouseCoopers LLP
June 29, 2000









<PAGE>

                   Neurogen Corporation 401(k) Retirement Plan
                Statements of Net Assets Available for Benefits


                                                          December 31,
                                                     1999             1998
                                                     ----             ----
ASSETS:

Employer contribution receivable                $   131,187      $    47,103
Employee contribution receivable                          -           18,954

Investments (See notes 3 and 4)                   6,071,265        4,617,741

                                                  ---------        ---------
    Net assets available for benefits           $ 6,202,452      $ 4,683,798
                                                  =========        =========


The accompanying notes are an integral part of the financial statements.


<PAGE>

                   Neurogen Corporation 401(k) Retirement Plan
                 Statement of Changes in Net Assets Available for Benefits

<TABLE>
<CAPTION>

<S>                                 <C>



                                                                Year Ended
                                                             December 31, 1999
                                                            =================

Additions to net assets available for benefits:

Contributions received or receivable from:

    Employer                                                   $   551,820
    Employees                                                      825,085
                                                               -----------
    Total contributions                                          1,376,905

Net appreciation in fair value of investments                      453,935
Interest repayments                                                  8,221
                                                               -----------
    Total additions                                              1,839,061


Deductions from net assets available for benefits:


Benefits paid to participants                                     (308,420)
Administrative expenses                                            (11,987)
                                                               -----------
   Total deductions                                               (320,407)
                                                               -----------
      Net increase                                               1,518,654

Net assets available for benefits:

Beginning of year                                                4,683,798
                                                               -----------

End of year                                                    $ 6,202,452
                                                               ===========



The accompanying notes are an integral part of the financial statements.

</TABLE>
<PAGE>



                              Neurogen Corporation

                             401(k) Retirement Plan

                          NOTES TO FINANCIAL STATEMENTS

1. Description of the Plan:

General
-------

The  Neurogen  Corporation  401(k)  Retirement  Plan (the  "Plan")  is a defined
contribution plan administered by Neurogen Corporation (the "Company"). The Plan
is subject to the provisions of the Employee  Retirement  Income Security Act of
1974  ("ERISA")  and is intended  to meet the  requirements  of Section  401(a),
401(k),  and  501(a) of the  Internal  Revenue  Code of 1986,  as  amended  (the
"Code").  All full-time  employees of the Company are eligible to participate in
the Plan on the first day of a calendar quarter  following the date on which the
employee  first  completed  an  hour  of  service.  The  following  is  a  brief
description of the Plan.  Participants  should refer to the Plan agreement for a
more complete description of the Plan's provisions.

Effective November 1, 1999, the Plan was amended and restated, as Alliance Trust
Company ("Alliance") was appointed trustee and recordkeeper of the Plan, and the
number of investment  options available to participants was increased.  Prior to
the  transfer  of Plan  assets to  Alliance,  Plan  participants  selected a new
investment  mix based on the increased  number of investment  options  available
from Alliance. Plan assets transferred to Alliance were invested either in funds
comparable  to those offered by the previous  custodians  or in cash  management
vehicles until Alliance  transferred funds to investment  elections in which the
previous custodians did not offer a comparable investment option. The conversion
initiated a "Black Out" period beginning November 1, 1999 and continuing through
February 23, 2000. During this period,  employee and employer  contributions and
investment  income  earned on Plan assets  continued to be recorded by Alliance.
However,  participants  were not able to withdraw  assets from their accounts or
make changes in investment  elections.  Towards the end of the Black Out period,
Plan assets were invested into the funds elected by each participant.

The Company,  as the  administrator  of the Plan, is responsible for determining
employer contributions,  determining limits if any, on loan requests,  reviewing
financial  hardship  requests for  participant  withdrawals and to set rules and
administrative  policy as it may deem  necessary to carry out the  provisions of
the Plan.

Contributions
-------------

Employees  may  elect to  contribute  up to 15% of  their  earnings  or  $10,000
whichever  is less.  Contribution  rates  may be  changed  on the first day of a
calendar quarter. Participants direct the investment of their contributions into
various investment options offered by the Plan.  The Plan currently offers 21
pooled equity funds, 3 pooled fixed income funds and Neurogen common stock as
investment options for participants.  The options may be changed daily by
participants.

The Plan provides that the Company will match the employee's  contribution in an
amount  equal  to  100%  of  the  participant's  contribution  up to  6% of  the
participant's gross pay. The matching  contribution is made on a quarterly basis
and is composed of two parts.  One-third of the contribution is in cash that may
be invested in any of the investment  funds offered.  The other two-thirds is in
Neurogen stock and may not be transferred to another investment fund.

Participant accounts
--------------------

Each participant's  account is credited with the participant's  contribution and
allocations  of the  Company's  matching  contribution,  and  Plan  earnings  as
described in the Plan  document.  The benefit to which a participant is entitled
is the benefit that can be provided from the participant's vested account.

Vesting
-------

Participants vest on employer  matching  contributions at a rate of 25% for each
whole year of service and are 100% vested after four years of credited service.
Participants are vested immediately in their contributions plus actual earnings
thereon.


Loans and Withdrawals
---------------------

Participants  may borrow from their fund  accounts a minimum of $1,000,  up to a
maximum equal to the lesser of $50,000,  or 50% of their vested account balance.
Loan terms vary with the maximum being ten years.  The loans are  collateralized
by the balance in the  participant's  account and bear  interest at a rate of 1%
over the prime rate.

A participant  may withdraw all or any portion of his vested  account  resulting
from his contributions and earnings thereon, subject to proof of hardship due to
an immediate and  significant  financial  need as further  described in the Plan
document. The Plan administrator in accordance with nondiscriminatory  standards
applied  uniformly to all  participants  similarly  makes the  determination  of
financial hardship.

Payment of Benefits
-------------------

On termination of service due to death, disability or retirement,  a participant
may elect to receive a lump-sum  amount equal to the value of the  participant's
vested interest in his or her account.  If a participant  terminates  employment
but  termination  is  not  due to  death,  disability  or  retirement,  and  the
participant is not yet 65, the  participant  may keep his account balance in the
Plan if it is higher than $5,000. If the participant chooses  distribution,  the
distribution  will  occur  as soon as  practicable  after  the  participant  has
completed the proper form providing  instruction as to where the funds should be
transferred.

Forfeited Accounts
------------------

Any forfeitures will first be applied to pay expenses under the Plan which would
otherwise  be paid  by the  employer.  Remaining  forfeitures,  if any,  will be
utilized to reduce the employer contribution.  During 1999,  administrative fees
for the Plan were  reduced  by $2,284  from  forfeited  nonvested  accounts.  At
December 31, 1999, forfeited nonvested accounts totaled $5,217.

2. Summary of Accounting Policies:

Basis of Accounting
-------------------

The financial  statements of the Plan are prepared  under the accrual  method of
accounting.

Use of Estimates
----------------

The preparation of financial  statements in conformity  with generally  accepted
accounting principles requires management to make estimates and assumptions that
affect the reported amounts of assets,  liabilities,  and changes  therein,  and
disclosure of contingent  assets and  liabilities.  Actual  results could differ
from those estimates.

Investment Valuation and Income Recognition
-------------------------------------------

The pooled equity and fixed income fund accounts are stated at fair value, which
is based upon quoted market prices that  represent the net asset value of shares
held by the Plan at year-end.  The Company  stock is valued at its quoted market
price.

The Plan  presents  in the  statement  of changes in net  assets  available  for
benefits  the  net  appreciation   (depreciation)  in  the  fair  value  of  its
investments  which  consists of the realized  gains or losses and the unrealized
appreciation (depreciation) on those investments, and investment income from the
pooled accounts.

Purchases  and  sales are  recorded  at the trade  date and  interest  income is
recorded on the accrual basis.

Plan Expenses
-------------

Transaction  fees are offset by forfeitures,  with any expenses in excess of the
forfeiture  being  paid  by the  Company.  The  Company  incurred  recordkeeping
expenses of $49,122 and $49,338 for the Plan years 1999 and 1998,  respectively,
which were not charged to the Plan. Trustee fees are charged to the participants
on an allocation  basis. In addition,  the participant pays loan  administrative
expenses of $75 per loan.

Payment of Benefits
-------------------

Benefits are recorded when paid.

Adoption of Recent Accounting Guidance
--------------------------------------

In 1999,  Statement of Position  99-3,  Accounting  for and Reporting of Certain
Defined  Contribution Benefit Plan Investments and Other Disclosure Matters (SOP
99-3),  was issued and is effective  for  financial  statements  with plan years
ending after  December 15, 1999. The Plan's  financial  statements and footnotes
reflect the provisions of SOP 99-3.
<PAGE>

3.  Investments

The  following  presents  investments  that  represent  5 percent or more of the
Plan's net assets.
<TABLE>
<CAPTION>


                                                                        December 31,
                                                                   1999             1998
                                                                   ----             ----


<S>                                                             <C>               <C>
Neurogen Corporation common stock,                            $   949,938      $  614,320
 57,572 and 35,104 shares, respectively

Fidelity Contrafund, 28,156 shares                            $ 1,689,906           N/A

Vanguard/Primecap Fund, 16,200 shares                         $ 1,009,930           N/A

American Performance Treasury Fund, 1,650,720 shares          $ 1,650,720           N/A

Manulife Money Market Fund, 3,122 shares                            N/A        $  260,058

Manulife Growth & Income Fund, 21,320 shares                        N/A        $  767,683

Manulife Growth Opportunities Fund, 18,907 shares                   N/A        $1,215,470

Manulife Contra Fund, 13,145 shares                                 N/A        $1,049,217


During 1999, the Plan's investments (including realized gains and losses and the
unrealized  appreciation  (depreciation)  on those  investments,  and investment
income from interest and dividends)appreciated in value by $453,935 as follows:

Pooled funds                              $   404,987
Common stock                                   48,948
                                          ------------
                                          $   453,935

</TABLE>

4.  Nonparticipant-Directed Investments

Information  about the net assets and the significant  components of the changes
in net assets relating to the nonparticipant-directed investments is as follows:

                                           December 31,
                                      1999             1998
                                      ----             ----
Net Assets:
 Restricted common stock            $ 645,810        $ 299,915


                                           Year Ended
                                        December 31, 1999
                                        -----------------
Changes in Net Assets:
 Contributions                             $ 312,555
 Net appreciation                             47,888
 Benefit paid to participants                 (8,705)
 Transfer to participant-directed             (5,843)
  investments                              ----------
                                           $ 345,895
                                           ==========



5.  Related-Party Transactions

Certain Plan  investments  are shares of pooled funds managed by Alliance  Trust
Company  ("Alliance").  Alliance  is the  trustee  as  defined  by the Plan and,
therefore, these transactions qualify as party-in-interest transactions.

6.  Plan Termination

Although  it has not  expressed  any intent to do so, the  Company has the right
under the Plan to discontinue its contributions at any time and to terminate the
Plan,  subject to the  provisions  of ERISA.  In the event of Plan  termination,
participants would become 100 percent vested in their employer contributions.

7.  Tax Status

The Internal Revenue Service has determined and informed the Company by a letter
dated October 22, 1996, that the Plan, as then designed,  was in compliance with
the  applicable  requirements  of the Internal  Revenue Code.  The Plan has been
amended  since   receiving  the   determination   letter.   However,   the  Plan
administrator  and the Plan's tax  counsel  believe  that the Plan is  currently
designed and being operated in compliance  with the applicable  requirements  of
the Internal Revenue Code.

8.  Reconciliation of Financial Statements to Form 5500

The following is a  reconciliation  of net assets available for benefits per the
financial statements at December 31, 1999 to Form 5500:

                                                                   1999
                                                                -----------

Net assets available for benefits per
 the financial statements                                        $6,202,452
Amounts allocated to withdrawing participants                      (186,600)
                                                                -----------
Net assets available for benefits per the Form 5500              $6,015,852
                                                                ===========

The  following is a  reconciliation  of benefits  paid to  participants  per the
financial statements for the year ended December 31, 1999 to Form 5500:

Benefits paid to participants per the
 financial statements                                            $  308,420
Add: Amounts allocated to withdrawing
 participants at December 31, 1999                                  186,600
                                                                -----------
Benefits paid to participants per Form 5500                      $  495,020
                                                                ===========

Amounts allocated to withdrawing  participants are recorded on the Form 5500 for
benefit  claims that have been  processed  and  approved  for  payment  prior to
December 31, 1999, but not yet paid as of that date.





<TABLE>
<CAPTION>

<PAGE>
                   Neurogen Corporation 401(k) Retirement Plan
                             Supplemental Schedule
         Schedule of Assets Held for Investment Purposes At End of Year


<S>       <C>                     <C>                                           <C>            <C>

                                December 31, 1999

          (b) Identity of issue,  (c) Description of investment
           borrower,lessor or      including maturity date, rate of interest,
(a)        similar party           collateral,par, or maturity value            (d) Cost       (e) Current value
---       ----------------------   ---------------------------------            --------       -----------------
 *        Neurogen Corporation     Restricted common stock, par value $.025         **         $        645,810

 *        Neurogen Corporation     Unrestricted common stock, par value $.025      ***                  304,128

 *        Participants             Participant loans with interest
                                   rates between 8.75% and 9.75%,
                                   collaterized by participant
                                   account balances                                ***                  116,359

          Fidelity Group           Fidelity Contrafund                             ***                1,689,906

          Harbor Fund              Harbor International Fund                       ***                  222,483

          Janus                    Janus Worldwide Fund                            ***                  178,902

          Vanguard Group           Vanguard/Primecap Fund                          ***                1,009,930

          Harbor Fund              Harbor Bond Fund                                ***                   67,778

          Vanguard Group           Vanguard High Yield Corporate Fund              ***                  180,169

 *        Alliance Trust Company   American Performance Treasury Fund              ***                1,650,720

 *        Alliance Trust Company   American Performance Cash Management Fund       ***                    5,080







*  Identified as a party in interest

** Information not available from recordkeeper

*** Cost information has been omitted for participant-directed investments



</TABLE>
<PAGE>

<TABLE>
<CAPTION>

                   Neurogen Corporation 401(k) Retirement Plan
                             Supplemental Schedule
                       Schedule of Reportable Transactions

<S>                                        <C>              <C>            <C>          <C>          <C>
                          Year Ended December 31, 1999

Series of transactions exceeding 5% of current value of Plan assets as of January 1, 1999

                      (b)Description of asset
(a)Identity of        (include interest rate and                  (c)Purchase   (d)Selling   (e)Lease    (f)Expense incurred
party involved         maturity in case of a loan)                   price         price        rental    with transaction
--------------------   -------------------------------------      -----------   ----------   ----------   ----------------


Neurogen Corporation   Neurogen Corporation Restricted Stock      $  298,007         N/A      $   -        $      -



<S>                     <C>                                       <C>           <C>               <C>
                        (b)Description of asset                                     (h)Current value
(a)Identity of          (include interest rate and                    (g)Cost of       of asset on     (i)Net gain
party involved           maturity in case of a loan)                     asset       transaction date     or (loss)
--------------------    --------------------------------------        ----------    -----------------   ----------


Neurogen Corporation    Neurogen Corporation Restricted Stock         $  298,007    $  298,007          $   -






</TABLE>

<PAGE>

<TABLE>
<CAPTION>


                   Neurogen Corporation 401(k) Retirement Plan
                              Supplemental Schedule
                       Schedule of Nonexempt Transactions
                      For the Year Ended December 31, 1999

<S>                    <C>                            <C>                                   <C>              <C>           <C>

                                                     (c)Description of transactions
                       (b)Relationship to Plan,      including maturity date, rate
(a) Identity of        employer or other             of interest , collerateral, par       (d) Purchase    (e) Selling   (f) Lease
party involved         party-in-interest             or maturity value                     price           price         rental
---------------        --------------------------    -----------------------------------   -------------   ------------  ----------

Neurogen Corporation   Plan sponsor                  January-June loan repayments for       $        -      $        -    $      -
                                                     one Plan participant were deposited
                                                     into the Plan on June 30, 1999







                       (b) Relationship to Plan,   (g) Expenses incurred                                    (j) Net gain or
(a) Identity of        employer or other            in connection            (h) Cost    (i) Current value  (loss) on each
party involved         party-in-interest            with transaction         of asset    of asset           transaction
---------------        --------------------------   ----------------------   ---------   -----------------  -----------------

Neurogen Corporation   Plan Sponsor                 $        -               $   1,347   $    1,347         $        -








</TABLE>

<PAGE>



                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
trustees (or other persons who administer the plan) have duly caused this annual
report to be signed on its behalf by the undersigned hereunto duly authorized.

                                      Neurogen Corporation 401(k)Retirement Plan

                                            Administrator:  Neurogen Corporation



Date:  June 30, 2000            By: /s/ STEPHEN R. DAVIS
                                    ---------------------
                                Stephen R. Davis

                                Senior Vice President and Chief Business Officer

<PAGE>
                                                                      Exhibit 23



                       CONSENT OF INDEPENDENT ACCOUNTANTS

We  hereby  consent  to the  incorporation  by  reference  in  the  Registration
Statement on Form S-8 (No. 333-07957) of the Neurogen  Corporation of our report
dated  June 29,  2000  relating  to the  financial  statements  of the  Neurogen
Corporation 401(k) Retirement Plan, which appears in this Form 11-K.







PricewaterhouseCoopers LLP
Hartford, Connecticut
June 29, 2000






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